SkillCompiler/data/format-preference/natural-instructions/tasks/task1447_drug_extraction_ade.json

{
    "Contributors": [
        "Ishani Mondal"
    ],
    "Source": [
        "ade_corpus_v2"
    ],
    "URL": [
        "https://github.com/trunghlt/AdverseDrugReaction/tree/master/ADE-Corpus-V2"
    ],
    "Categories": [
        "Named Entity Recognition"
    ],
    "Reasoning": [],
    "Definition": [
        "In this task, you will be given sentences in which your task is to recognize the name of the drug or medicine. Drugs are substances that change a person's mental or physical state. They can affect how your brain works, how you feel and behave, your understanding, and your senses. Although there might be several correct answers, you need to write one of them."
    ],
    "Input_language": [
        "English"
    ],
    "Output_language": [
        "English"
    ],
    "Instruction_language": [
        "English"
    ],
    "Domains": [
        "Biology -> Clinical Knowledge",
        "Healthcare"
    ],
    "Positive Examples": [
        {
            "input": "Acute pain was observed after taking MTX",
            "output": "MTX",
            "explanation": "MTX is a medicine which has been mentioned here, and hence the name should be tagged."
        },
        {
            "input": "METHODS: We report two cases of pseudoporphyria caused by naproxen",
            "output": "naproxen",
            "explanation": "Naproxen is the medicine which causes the disorder pseudoporphyria."
        }
    ],
    "Negative Examples": [
        {
            "input": "She was suffering from gastric cancer for a prolonged period of time.",
            "output": "gastric cancer",
            "explanation": "Gastric cancer is a disorder which has been reported to occur among the patients, and hence should not be categorized as drug."
        },
        {
            "input": "We describe the side effects of 5-FU in a colon cancer patient",
            "output": "5-FU in a colon cancer patient",
            "explanation": "Reference of the type of patients, on which the side effects are described, are irrevalent to tag the drug names, and hence should not be tagged."
        }
    ],
    "Instances": [
        {
            "id": "task1447-e4cd06c3bd90405e8942bc38904157bb",
            "input": "Intravenous azithromycin-induced ototoxicity.",
            "output": [
                "azithromycin"
            ]
        },
        {
            "id": "task1447-2c8de11d728f4bf58b8ca05b72d76bb9",
            "input": "Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.",
            "output": [
                "dihydrotachysterol"
            ]
        },
        {
            "id": "task1447-6cd517c20f93463c84fc33f6f47a569f",
            "input": "Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.",
            "output": [
                "dihydrotachysterol"
            ]
        },
        {
            "id": "task1447-7c0f963f615f436091dedd0e77494644",
            "input": "Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.",
            "output": [
                "Naproxen"
            ]
        },
        {
            "id": "task1447-aaed859c78214bc890a3bf3b48b384d8",
            "input": "BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-376bfe7b012d4996b68c3e1c6bb72994",
            "input": "CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-50c169856cae4f93a4139015dc8195dd",
            "input": "Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-48ff290e0c6d4cab8f6092d7d1abc8fb",
            "input": "This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.",
            "output": [
                "BH-AC"
            ]
        },
        {
            "id": "task1447-2f8eb61183e948b6ac0b9119167f0bbe",
            "input": "In one case, the readministration of riluzole was followed by the relapse of hepatitis.",
            "output": [
                "riluzole"
            ]
        },
        {
            "id": "task1447-bb25634af769404eb341cfddbe909fde",
            "input": "We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",
            "output": [
                "riluzole"
            ]
        },
        {
            "id": "task1447-e5bd6d67d91946fe8c1c6622ac756eb9",
            "input": "Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.",
            "output": [
                "5-aminosalicylic acid"
            ]
        },
        {
            "id": "task1447-58fe3c37522e41d4b40a8adeec17f0fc",
            "input": "Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.",
            "output": [
                "lidocaine"
            ]
        },
        {
            "id": "task1447-2265630448cd46649cb0cc17bb3cc4e6",
            "input": "Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-f544b140fc3f42058fed337bbbe0ccdb",
            "input": "An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-8cf81f52710340f28a2273459e683a67",
            "input": "We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.",
            "output": [
                "epoprostenol"
            ]
        },
        {
            "id": "task1447-50370ff8f4b242aaacfbf6727bf05585",
            "input": "A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-1a5537cd78a645829ba45edd769e99dc",
            "input": "Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.",
            "output": [
                "Hydroxyurea"
            ]
        },
        {
            "id": "task1447-64d49ddd58464020a2c7d467710c855b",
            "input": "The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-a3ee855c323c4b779ab0b67ee7579d74",
            "input": "This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-daeeb8bbd1364c579baa120d05bf31a1",
            "input": "Allergic and irritant contact dermatitis to calcipotriol.",
            "output": [
                "calcipotriol"
            ]
        },
        {
            "id": "task1447-904fa9f00dff48d983e62c86e953932f",
            "input": "The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.",
            "output": [
                "calcipotriol"
            ]
        },
        {
            "id": "task1447-b16df23335914261aba5026b4724ab78",
            "input": "Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.",
            "output": [
                "pravastatin"
            ]
        },
        {
            "id": "task1447-016f659be1364618824f6986ae84bf11",
            "input": "Pravastatin is associated with myotonia in animals.",
            "output": [
                "Pravastatin"
            ]
        },
        {
            "id": "task1447-9660be57c56444d5a50555556e1c17ce",
            "input": "This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.",
            "output": [
                "pravastatin"
            ]
        },
        {
            "id": "task1447-daaefdd6759141e881041452a9c82b14",
            "input": "CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-9cab4bcb41a84f9793cf2d8e88c4128d",
            "input": "Fixed drug eruption in hands caused by omeprazole.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-69803c42538d4470ac34d5ebb781c179",
            "input": "The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-220be06b043c4389af5f34b249922bc9",
            "input": "Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.",
            "output": [
                "salazosulfapyridine"
            ]
        },
        {
            "id": "task1447-ffb4d7f54bac46a6bf99445dcc9e85ba",
            "input": "We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.",
            "output": [
                "salazosulfapyridine"
            ]
        },
        {
            "id": "task1447-382355bdb8e84f0ca11852e7d7948973",
            "input": "CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-4faed0f5909341efb866c307c68b4290",
            "input": "DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.",
            "output": [
                "Olanzapine"
            ]
        },
        {
            "id": "task1447-cc33e58d7558432a85fd435336d1bb5c",
            "input": "Marked elevation of serum creatine kinase associated with olanzapine therapy.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-7f8ae013234f4bb88377c02e4a99be8d",
            "input": "OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-649fa04ba7bc4f1faea60d0fcec02c09",
            "input": "Diclofenac-associated hepatitis.",
            "output": [
                "Diclofenac"
            ]
        },
        {
            "id": "task1447-e45e134049a545a7ac11361b6cb398d5",
            "input": "This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.",
            "output": [
                "diclofenac"
            ]
        },
        {
            "id": "task1447-7e3e2d83ce5e42daaeeb600aff775731",
            "input": "2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.",
            "output": [
                "2-CdA"
            ]
        },
        {
            "id": "task1447-29d782c368e147fc8ef5317b97a034a9",
            "input": "One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-dd35a11ae8284071a7031b167e0e0a4d",
            "input": "Priapism as a complication of heparin therapy.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-214022b923ec461c87f752f342ca1ba9",
            "input": "OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-5f875f7858764facb56d1f406b90ec1a",
            "input": "Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.",
            "output": [
                "all-trans-retinoic acid"
            ]
        },
        {
            "id": "task1447-d7b7f23e7a344f29b5b324145b34a4a1",
            "input": "Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.",
            "output": [
                "paroxetine"
            ]
        },
        {
            "id": "task1447-063afe06d6914567bc2fb005f60b4760",
            "input": "Hair loss associated with paroxetine treatment: a case report.",
            "output": [
                "paroxetine"
            ]
        },
        {
            "id": "task1447-a2f3d08790e348b5850e7e9f133991a2",
            "input": "We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.",
            "output": [
                "paroxetine"
            ]
        },
        {
            "id": "task1447-e009e1e125f046fd8f0e2f1d2f2ee566",
            "input": "CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-76b4213eddd54c2da38c04229bf9bdae",
            "input": "Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.",
            "output": [
                "neutral protamine Hagedorn (NPH) insulin"
            ]
        },
        {
            "id": "task1447-b260afb657a94953ae1d48b90bb659df",
            "input": "Protamine allergy as a complication of insulin hypersensitivity: A case report.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-ddc4fcad500343c6969e45e06a96e6bb",
            "input": "She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-a7447203e2f04dc8909b055a2ee26cce",
            "input": "Apparent central nervous system depression in infants after the use of topical brimonidine.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-9d1881f969874a05bac954d0f1b88631",
            "input": "CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-b4bdb006b4f04e09af556ede4e6269b0",
            "input": "PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-cab7e53c2a48406caa5720085c8a7174",
            "input": "Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.",
            "output": [
                "ceftriaxone"
            ]
        },
        {
            "id": "task1447-73bdb264d7a5404699866d37b9614e36",
            "input": "Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-17ddaa00710a48a0a491c6bae93b89be",
            "input": "Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-99c314a8c9ed4ec8b85d747b5ea5f2e0",
            "input": "With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.",
            "output": [
                " minocycline"
            ]
        },
        {
            "id": "task1447-57d3902bf99243c78024a3e489780956",
            "input": "We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-834500ab1ccb441196725f023f1d8ddb",
            "input": "We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-5cd658769e4f464fa526a1f1c449656d",
            "input": "An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-92ae70a78ade4eb29a113670225f3833",
            "input": "The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-4131749f60e24085abe9b8dd587e633f",
            "input": "This is the first report of a possible association between an acute cardiovascular event and venlafaxine.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-db7841e6fd184be1967e4cdd8ad3ff9d",
            "input": "We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-9e51cf61681c4fd08eccb1de83ad5426",
            "input": "Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-f9a3b81534554b2b87309c9709157b7d",
            "input": "We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-4adfa42dee424ee2be195292854254d2",
            "input": "In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-00e55c225d6b4e94abd14792a2b2015c",
            "input": "Paradoxical seizures in phenytoin toxicity.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-932c282d10ba418aa6303fcf87e05ac9",
            "input": "We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-48f61d454e35480484bb2396c9ab7a02",
            "input": "CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.",
            "output": [
                "losartan"
            ]
        },
        {
            "id": "task1447-01e87e4aa4f74775bb3b32361119a97d",
            "input": "Losartan-induced angioedema.",
            "output": [
                "Losartan"
            ]
        },
        {
            "id": "task1447-ffeb07daa7ce4fdaa55a971cfe3f2167",
            "input": "OBJECTIVE: To report a case of angioedema associated with losartan administration.",
            "output": [
                "losartan"
            ]
        },
        {
            "id": "task1447-b09293341c2c4208880289bfc7cd8ecc",
            "input": "The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.",
            "output": [
                "losartan"
            ]
        },
        {
            "id": "task1447-39f8b40c409d48768bc68d4346a098da",
            "input": "We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-74c0463386e748d1a0bd6c550a19b93e",
            "input": "Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.",
            "output": [
                "Heparin"
            ]
        },
        {
            "id": "task1447-cab789bd21dc4861a3d1bbfef2ed039c",
            "input": "Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-68ca21a1c6e5486fbc5cd6a74ecb8e50",
            "input": "There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-97fe11e5a9ee4415967f888bcbb8011e",
            "input": "Taxane-induced glaucoma.",
            "output": [
                "Taxane"
            ]
        },
        {
            "id": "task1447-6929f34a4cfa4653abf325db798db7fe",
            "input": "We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.",
            "output": [
                "doxetaxel"
            ]
        },
        {
            "id": "task1447-8a9399bfa71847fe8a8c4a6d3848b479",
            "input": "Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.",
            "output": [
                "sodium phosphate"
            ]
        },
        {
            "id": "task1447-256b207edf2345fbab2730d1bae6e53c",
            "input": "We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-1c6d19606d2940649587e0662b4561c6",
            "input": "Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.",
            "output": [
                "diphenylhydantoin"
            ]
        },
        {
            "id": "task1447-6e95abc425f74031ab8afa9375ce1263",
            "input": "Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.",
            "output": [
                "D-Pen"
            ]
        },
        {
            "id": "task1447-35ca099326d845ffbfe616a0cafe620c",
            "input": "In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-360e3f7dec0a4892b142708a26af2a0e",
            "input": "These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.",
            "output": [
                "D-Pen"
            ]
        },
        {
            "id": "task1447-402cf025e6bd48f587dcc890bd4f2581",
            "input": "A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.",
            "output": [
                "methimazole"
            ]
        },
        {
            "id": "task1447-af48cf24525047b788c80e944e766493",
            "input": "Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-0a49e375659b45178bb8f8917233a8f8",
            "input": "The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-ea60607b8feb4dee85dab66e8c3e5dfe",
            "input": "The relationship between infliximab treatment and lymphoma in Crohn's disease.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-dba2236c6db64157a70cc0ef4e25d1dd",
            "input": "The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-a164ca8dcb2a44e79599d22db92f56c3",
            "input": "We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-3df86f6e108c49538304b88ac84e5100",
            "input": "Codeine intoxication in the neonate.",
            "output": [
                "Codeine"
            ]
        },
        {
            "id": "task1447-df45aa49e0ae4daebc0295c9c6518083",
            "input": "We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.",
            "output": [
                "codeine"
            ]
        },
        {
            "id": "task1447-41f1800eb3cc4d9a8e5b91558995eada",
            "input": "Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.",
            "output": [
                "HU"
            ]
        },
        {
            "id": "task1447-8c7b983ce5f34dc1954ea24bb757819e",
            "input": "We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.",
            "output": [
                "HU"
            ]
        },
        {
            "id": "task1447-d0fe3b1779254f78867c75faebd69530",
            "input": "A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.",
            "output": [
                "oolong tea"
            ]
        },
        {
            "id": "task1447-e5a43c69dcd34203a6b57a7d5229e398",
            "input": "After abstinence from oolong tea his delirium resolved.",
            "output": [
                "oolong tea"
            ]
        },
        {
            "id": "task1447-459853bfc7de469ab978fbb464be4ce9",
            "input": "We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.",
            "output": [
                "indinavir"
            ]
        },
        {
            "id": "task1447-1038f39b7ba942dbb4c7860456adc97a",
            "input": "Elevated serum triglycerides with clozapine resolved with risperidone in four patients.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-a02e4889dba0410f9cfe01136b34d883",
            "input": "In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-d895e6d652f240adb8ae34c08c123fdf",
            "input": "This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-e5e794c45774430db2bbfa9bf2745c86",
            "input": "Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-4f61093fd9504a09bef34e615c237de1",
            "input": "To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-e27514c0073b4b39b3bd061beab5ac84",
            "input": "We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-09abb9697bbe47a1b46a57acd4f4a0d0",
            "input": "In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.",
            "output": [
                "pyridostigmine"
            ]
        },
        {
            "id": "task1447-a28bdb67cab7449083707232536e73e5",
            "input": "A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-ea6d42cae7204fc88a7c310b253fab67",
            "input": "Salicylate intoxication was excluded, and theophylline was finally incriminated.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-0de0224bbc914ae3b681cacad92e4a5f",
            "input": "Theophylline intoxication mimicking diabetic ketoacidosis in a child.",
            "output": [
                "Theophylline"
            ]
        },
        {
            "id": "task1447-e1b3ef596ac245bbafc4afe812121a05",
            "input": "This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-886fb7d0ca7e4b33b5c04e39fbd22a02",
            "input": "Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-d5ecbafbe6b84ad9a53a72c8bd1bd195",
            "input": "Ten to 15% of patients treated with ifosfamide develop an encephalopathy.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-367cdc010a6142a9ad9cb10abbc73ecc",
            "input": "We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-0e28a3a8452e460a866ce074c17d2da2",
            "input": "Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.",
            "output": [
                "F VIII"
            ]
        },
        {
            "id": "task1447-69053e8cca794210bf42458d11a61a79",
            "input": "We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.",
            "output": [
                "F VIII"
            ]
        },
        {
            "id": "task1447-1308527578d140e186cec65cfd6ef016",
            "input": "A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.",
            "output": [
                "gliclazide"
            ]
        },
        {
            "id": "task1447-2f8a292ae4fa4c238dfff916af13872c",
            "input": "Gliclazide-induced acute hepatitis.",
            "output": [
                "Gliclazide"
            ]
        },
        {
            "id": "task1447-312e1a4de8284096908e8fb91525fe23",
            "input": "In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.",
            "output": [
                "gliclazide"
            ]
        },
        {
            "id": "task1447-770310f2d99a42478d735160b1b0a0d6",
            "input": "We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.",
            "output": [
                "gliclazide"
            ]
        },
        {
            "id": "task1447-1d53fe83ba1d4cfda026cec012529801",
            "input": "We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.",
            "output": [
                "gliclazide"
            ]
        },
        {
            "id": "task1447-6e53498ac84c418fbaee737bf2315b41",
            "input": "Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.",
            "output": [
                "TCA"
            ]
        },
        {
            "id": "task1447-59d55413c28748ed86e8571165d14aad",
            "input": "Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.",
            "output": [
                "TCA"
            ]
        },
        {
            "id": "task1447-4e875b4683bc4ed8a5ff02dc1f926695",
            "input": "The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).",
            "output": [
                "TCA"
            ]
        },
        {
            "id": "task1447-bc65f2dbf2cc46dbb63e8c0e603bd038",
            "input": "Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-95447cdcc9d04b5299e11372c6ff55e6",
            "input": "The spectrum of nitrofurantoin lung injury continues to widen.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-197e938a5a57464eba6ebca5ad4f52a8",
            "input": "The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-e6fdca05f4f84008b0246c3017ab18cf",
            "input": "We suggest that the previous classification of nitrofurantoin induced lung injury into \"acute\" and \"chronic\" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-ba883a96e87941f68173d853a2c4f647",
            "input": "Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-83374639414a48f5ae9351a8062f0677",
            "input": "Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-806c7d906f4b4e9dbd6f098a7b97c7fd",
            "input": "The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-b053b1c4c0c744889f04e64b351d41c8",
            "input": "This is the first report of UFT-induced scleroderma-like reaction.",
            "output": [
                "UFT"
            ]
        },
        {
            "id": "task1447-4d09ac452d9146989f4d4f056d887da1",
            "input": "We report a case of a scleroderma-like reaction induced by long-term administration of UFT.",
            "output": [
                "UFT"
            ]
        },
        {
            "id": "task1447-2b4ae1168f0e4188ba190fcb479821f6",
            "input": "Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-49c289ca27ce472692ac0a83eafa3b1e",
            "input": "Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-ea68d8e86a494eefa6306f4ce300f4f2",
            "input": "We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-86cb25c0f7134a67bfccf70f0b14d436",
            "input": "Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.",
            "output": [
                "Flecainide"
            ]
        },
        {
            "id": "task1447-57950ae2b91e43a88d29dceeab74db38",
            "input": "We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.",
            "output": [
                "flecainide"
            ]
        },
        {
            "id": "task1447-c6dfff27d3a246c2a9c9c88e2ecda38d",
            "input": "We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-139a712c25d44f2285893fc58c05f213",
            "input": "We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.",
            "output": [
                "vaccination against hepatitis B"
            ]
        },
        {
            "id": "task1447-3065a1e5fd2449eda6753c5f8aaeaaca",
            "input": "In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-55c93167204f47c8a99b65d61421fe16",
            "input": "This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.",
            "output": [
                "cocaine"
            ]
        },
        {
            "id": "task1447-925bf43efe8a48adaf31aecf6722cd1a",
            "input": "However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.",
            "output": [
                "troglitazone"
            ]
        },
        {
            "id": "task1447-e56e2f94a5d843319d385cd6b7c8b9ba",
            "input": "Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.",
            "output": [
                "troglitazone"
            ]
        },
        {
            "id": "task1447-2f58ea9f0d51472584ec4d3ac81d89d4",
            "input": "The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.",
            "output": [
                "troglitazone"
            ]
        },
        {
            "id": "task1447-d006f9bfb69d4a81b466b9603aa0bac9",
            "input": "Troglitazone-induced fulminant hepatic failure.",
            "output": [
                "Troglitazone"
            ]
        },
        {
            "id": "task1447-938aeb53279f4d42968945ff34042a85",
            "input": "Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.",
            "output": [
                "Nitrofurantoin"
            ]
        },
        {
            "id": "task1447-a13a403bbec74023ab2bacde1787a1b7",
            "input": "Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.",
            "output": [
                "Fluoxetine"
            ]
        },
        {
            "id": "task1447-6094b2e86292487884ea050a964aec9d",
            "input": "This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-9b8a438b8f414d9cac96dc9109863798",
            "input": "A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.",
            "output": [
                "zolmitriptan"
            ]
        },
        {
            "id": "task1447-027fd50f948a42c2b881ae28b6f7996f",
            "input": "Spinal cord infarction during use of zolmitriptan: a case report.",
            "output": [
                "zolmitriptan"
            ]
        },
        {
            "id": "task1447-fbe097f312b14a448dcd79d1e50c90c6",
            "input": "The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.",
            "output": [
                "zolmitriptan"
            ]
        },
        {
            "id": "task1447-6f34f0ae646a462c96647c85ace45698",
            "input": "CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-cf53adbfe26d441db38499c05a17beee",
            "input": "This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-1ccd3f5300d74ca19a06235dc0b8a2b2",
            "input": "Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.",
            "output": [
                "nimesulide"
            ]
        },
        {
            "id": "task1447-ac4f7c8c79a24071af5a67cd65e787e7",
            "input": "This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.",
            "output": [
                "nimesulide"
            ]
        },
        {
            "id": "task1447-02fd7e245e674520894adb136101bb4e",
            "input": "Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-8a9008521cb34c14a6c3406acb2431f0",
            "input": "Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-d2dc0a6f39434aaf8d6af895eb2cc6cf",
            "input": "The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-1990daaf3a9148aa8139e96a0c22c865",
            "input": "BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.",
            "output": [
                "Cyanamide"
            ]
        },
        {
            "id": "task1447-0c7d9af0137a48a9b8da20e80e1f1430",
            "input": "Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.",
            "output": [
                "cyanamide"
            ]
        },
        {
            "id": "task1447-f857fc09f4f245ebb86cab1402f82bba",
            "input": "Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.",
            "output": [
                "cyanamide"
            ]
        },
        {
            "id": "task1447-51df31daea5749809f7d003723dde10b",
            "input": "Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.",
            "output": [
                "Cyanamide"
            ]
        },
        {
            "id": "task1447-624bc3a21b204ded81dffa520298c539",
            "input": "When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.",
            "output": [
                "cyanamide"
            ]
        },
        {
            "id": "task1447-55a3a38e93dc4236aa9cbb9ebd356546",
            "input": "A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-4f8b09d876cc43fab37a82c617562b6f",
            "input": "A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-2f0a66a194e64d51bf732378005c9b1f",
            "input": "A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.",
            "output": [
                "naloxone"
            ]
        },
        {
            "id": "task1447-1719aab10adb4240a3c38be5a1e3f768",
            "input": "Nonconvulsive status epilepticus: the role of morphine and its antagonist.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-402e249462b042988d092a8422d4c953",
            "input": "Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-373d539380874f4889f970a15c0c5302",
            "input": "Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.",
            "output": [
                "CHOP"
            ]
        },
        {
            "id": "task1447-623c2957e26a493db3409fedc6a93bd1",
            "input": "A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-75541e430b204820ac214e9ad12588c5",
            "input": "HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.",
            "output": [
                "mitomycin C"
            ]
        },
        {
            "id": "task1447-30bd5d27238342a4b34156b8bf9a6c1c",
            "input": "An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-a3c92ac4dd6e4c16a249bfce2c6b7932",
            "input": "CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-c8d50f3a539a44c28220a957be85d833",
            "input": "OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-52656fb7d7f64d60afd0ae7feb0fae74",
            "input": "PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-1b45345c06e24934b1b8faef1e4eae15",
            "input": "RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-b1b9b919d1324015b410e58a61fe98bd",
            "input": "However, recurrent staphylococcus aureus sepsis developed during CyA therapy.",
            "output": [
                "CyA"
            ]
        },
        {
            "id": "task1447-db0b9f353e1b472cbea0546d47a4f300",
            "input": "A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-c415fd64a8c44f7ba238c72f5792a260",
            "input": "Colchicine-induced myopathy in renal failure.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-82a62632d51c41eaa2dc669ff429846b",
            "input": "A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.",
            "output": [
                "paclitaxel"
            ]
        },
        {
            "id": "task1447-b598c43bff4c4625ad25d4a41b692804",
            "input": "Physicians should be aware that PLP can occur after initiation of paclitaxel.",
            "output": [
                "paclitaxel"
            ]
        },
        {
            "id": "task1447-109bc66e549340cdafa23c72c0f0397f",
            "input": "Our experience supports hemodialysis for ESRF patients with atenolol toxicity.",
            "output": [
                "atenolol"
            ]
        },
        {
            "id": "task1447-8ab3d96f262747fc91bec7209d573978",
            "input": "Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.",
            "output": [
                "gemfibrozil"
            ]
        },
        {
            "id": "task1447-6a99b8e8e50c4d81884941b17d5fb594",
            "input": "We describe a case of EGE manifested as an allergy to gemfibrozil.",
            "output": [
                "gemfibrozil"
            ]
        },
        {
            "id": "task1447-f70c5e7ad90449aabb4c59d3b767daa0",
            "input": "Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.",
            "output": [
                "propafenone"
            ]
        },
        {
            "id": "task1447-b7a93e863e114b488c8c9595d2780a8d",
            "input": "Propafenone-induced ataxia: report of three cases.",
            "output": [
                "Propafenone"
            ]
        },
        {
            "id": "task1447-adab5da7c03e40f6aa38c5a78b55e97c",
            "input": "We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.",
            "output": [
                "propafenone"
            ]
        },
        {
            "id": "task1447-bc81502f8db042328cd0a8643dcc9721",
            "input": "A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.",
            "output": [
                "pilsicainide"
            ]
        },
        {
            "id": "task1447-081e2ce0b4c949a78d56ba02c04ce776",
            "input": "When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.",
            "output": [
                "pilsicainide"
            ]
        },
        {
            "id": "task1447-1996904895f44ec49064d61c5d2dd386",
            "input": "The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-c29c429a46ef42ba9fcf1cb8e5faa04b",
            "input": "Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.",
            "output": [
                "tiagabine"
            ]
        },
        {
            "id": "task1447-7f5f41d3b8b5449087d842d4b3ca4dc9",
            "input": "The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.",
            "output": [
                "tiagabine"
            ]
        },
        {
            "id": "task1447-e0606c7b8bc4449e9467d36025a5a8a4",
            "input": "This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.",
            "output": [
                "tiagabine"
            ]
        },
        {
            "id": "task1447-185444d1ec574f87931cdbab075fde53",
            "input": "There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-032c40e9e96c49d6abf9163fe3d3dcbe",
            "input": "Protease inhibitor-induced carbamazepine toxicity.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-54c507c6a608499b8782753fe8e2346a",
            "input": "Anaphylaxis to calcitonin.",
            "output": [
                "calcitonin"
            ]
        },
        {
            "id": "task1447-96752fd4044e4ee899ddbf262a29c8eb",
            "input": "CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.",
            "output": [
                "calcitonin"
            ]
        },
        {
            "id": "task1447-f69cb5971ecc4e9eb877b482eccf5dee",
            "input": "The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.",
            "output": [
                "Miacalcic"
            ]
        },
        {
            "id": "task1447-81885995575e4ad8af91a26f7f416fed",
            "input": "Minocycline as a cause of drug-induced autoimmune hepatitis.",
            "output": [
                "Minocycline"
            ]
        },
        {
            "id": "task1447-c901b874db7044e4b675b674ac6ae7e1",
            "input": "Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.",
            "output": [
                "Minocycline"
            ]
        },
        {
            "id": "task1447-fbe3813cd65b41e3adb469b6fb9c1c7c",
            "input": "We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-d585e533a6664bb5b9263591ebdd7a48",
            "input": "We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-2625e0d8b86f46b2ae9d8c9dc7a7d737",
            "input": "Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.",
            "output": [
                "5-aminosalicylic acid"
            ]
        },
        {
            "id": "task1447-7cc262e3f83348879d61abd2be3c9386",
            "input": "We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.",
            "output": [
                "5-aminosalicylic acid"
            ]
        },
        {
            "id": "task1447-be5ddfe49222448791ac6e903af5be42",
            "input": "CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-1f6989db46f040999e8bfedce551aaab",
            "input": "Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-2f8808856b0e4306818c469aabe900f3",
            "input": "PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-57046448b9fc4fa5853bcc0823960d98",
            "input": "The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-5bedc604cea94437adda6258da3d5adc",
            "input": "The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-a5224c87cb85452b90421f18e6ee1198",
            "input": "Depressive symptoms disappeared after interferon therapy was stopped.",
            "output": [
                "interferon"
            ]
        },
        {
            "id": "task1447-6df789667da64b408d94f9d8d2ff0803",
            "input": "While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-a09f1f0f962046b3b6f4fc417fe48050",
            "input": "Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-06f321940d50440fa737666025c3c7a5",
            "input": "Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-5dd9d38fe7744858ba3096e92c586d0f",
            "input": "We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
            "output": [
                "hyperbaric oxygen"
            ]
        },
        {
            "id": "task1447-56ef18647a21476bab52dc07cece2594",
            "input": "Nail staining from hydroquinone cream.",
            "output": [
                "hydroquinone"
            ]
        },
        {
            "id": "task1447-eea62042f66043828aeea9e8a158bed9",
            "input": "This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-8790c439d210401fbd9aa50124b95565",
            "input": "Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-e9e30b7655f84c4cbb9758d910c81150",
            "input": "MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.",
            "output": [
                "PCCs"
            ]
        },
        {
            "id": "task1447-5164edf7b22a4cdd89ffdaf31e2fa0f2",
            "input": "Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.",
            "output": [
                "prothrombin complex concentrate"
            ]
        },
        {
            "id": "task1447-daa2d703ad57412fadc99d8db3fd003c",
            "input": "We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.",
            "output": [
                "PCC"
            ]
        },
        {
            "id": "task1447-9824b194c2594bf3b184b5cd14ef67ef",
            "input": "Occult quinine-induced thrombocytopenia.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-fef0c0231b684a0aa1c53ff3ee443698",
            "input": "Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-d9f1019f6b0f4b8a8becd62bda9309de",
            "input": "An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-9e86425b93a24430adb18e50e1b7d273",
            "input": "CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-0c10475086fc46f09cb0e4ef3af72e45",
            "input": "In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.",
            "output": [
                "lithium carbonate"
            ]
        },
        {
            "id": "task1447-531c5fd7b73744feb6db3e9cb716ddd4",
            "input": "This concerns 2 male patients who experienced incontinence while taking venlafaxine.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-a04fad8abd344b1d8c8162bb2f7645d1",
            "input": "Case studies in heparin-induced thrombocytopenia.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-f7f1b7209f8b4402b9ca7be35efbf14c",
            "input": "Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-c499dfa38fd94ba6b6ce0c459e27d948",
            "input": "Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-d279ac9016da4445b8b8fd3db3b6800f",
            "input": "After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.",
            "output": [
                "lead"
            ]
        },
        {
            "id": "task1447-2f467b83c4724dd0a81a1d3a8e466479",
            "input": "Poorly controlled hypertension in a painter with chronic lead toxicity.",
            "output": [
                "lead"
            ]
        },
        {
            "id": "task1447-062086e8d07549c3b422493e429709cb",
            "input": "This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.",
            "output": [
                "lead"
            ]
        },
        {
            "id": "task1447-269a721a91284d0db1512bb35f295997",
            "input": "Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.",
            "output": [
                "nevirapine"
            ]
        },
        {
            "id": "task1447-a60741c7db2442939a782084dec1bfe5",
            "input": "Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.",
            "output": [
                "nevirapine"
            ]
        },
        {
            "id": "task1447-465c7ea7617f408aaa1e30fcd7abda05",
            "input": "We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.",
            "output": [
                "nevirapine"
            ]
        },
        {
            "id": "task1447-c254f2ba3bee4af7ab4967ade996f930",
            "input": "Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.",
            "output": [
                "acarbose"
            ]
        },
        {
            "id": "task1447-49ab416b65fa4ad58c04ac08adc95c9a",
            "input": "There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.",
            "output": [
                "losartan"
            ]
        },
        {
            "id": "task1447-74a9fd47da1f438096c87314bbc0acfc",
            "input": "A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-afbf6dc2bbed40bf91eb3040ac18c60e",
            "input": "Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-82f53b07027544f180458df9310bda5f",
            "input": "We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-7570948ffbc44774860ef2a15750a719",
            "input": "Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.",
            "output": [
                "cytosine arabinoside"
            ]
        },
        {
            "id": "task1447-87e66c1bbe7246d788dd3dc05f122ce8",
            "input": "The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-3ee1a267a73b4f1d99eb34cf1308394a",
            "input": "He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.",
            "output": [
                "clomipramine"
            ]
        },
        {
            "id": "task1447-a90b5fa897f94fae98daba12ebde3451",
            "input": "Quinine induced coagulopathy--a near fatal experience.",
            "output": [
                "Quinine"
            ]
        },
        {
            "id": "task1447-b630df5a6a41433f872db1c7914f77ab",
            "input": "The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-9a80ee91dd954ad7b8c218d363ef02ca",
            "input": "Dose-dependent olanzapine-associated leukopenia: three case reports.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-99db113586af492caeb7edafdb175970",
            "input": "We report three cases of patients who developed leukopenia during olanzapine treatment.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-bb3355bd897740cab719a1f5efc16e02",
            "input": "CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-4c5d44cf17da45168e88678a1730d1e4",
            "input": "Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-867ceecb75fb41babf670173df029fda",
            "input": "Ectropion secondary to bolus injection of 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-e859ec7a99124728bfa900275b4c4a49",
            "input": "Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-e8159e116d0548fb98dc6fed33e1210c",
            "input": "Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-f9002a4453c545b5830bdbae184bce3d",
            "input": "Renal failure associated with acetazolamide therapy for glaucoma.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-36dc9274b331439082c93e2e09a4a4f4",
            "input": "This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-7e4b9a09b5394f66861aafe4489a766d",
            "input": "Ischaemic colitis in a patient taking meloxicam.",
            "output": [
                "meloxicam"
            ]
        },
        {
            "id": "task1447-dfeb730fb1b1460f98ab8dd10d8f0958",
            "input": "Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.",
            "output": [
                "meloxicam"
            ]
        },
        {
            "id": "task1447-5547e841fa6a45dd88a576315729a1de",
            "input": "We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.",
            "output": [
                "meloxicam"
            ]
        },
        {
            "id": "task1447-6a95891dfa8846d5af860772fede8950",
            "input": "We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.",
            "output": [
                "meloxicam"
            ]
        },
        {
            "id": "task1447-ba8597fca8c04632a316166fd3dd5932",
            "input": "As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.",
            "output": [
                "spironolactone"
            ]
        },
        {
            "id": "task1447-df977c1ea25e4a3b9cedc19f5015b8c6",
            "input": "In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.",
            "output": [
                "spironolactone"
            ]
        },
        {
            "id": "task1447-3e732d0e248340b1b773926bd43632a1",
            "input": "In some cases this seems to happen because spironolactone causes diarrhoea.",
            "output": [
                "spironolactone"
            ]
        },
        {
            "id": "task1447-4ee7c54926d04dbebf6102c1a30a09d8",
            "input": "Serious adverse events experienced by patients with chronic heart failure taking spironolactone.",
            "output": [
                "spironolactone"
            ]
        },
        {
            "id": "task1447-1aba14c0b3cd43f3a18977aeb8714e22",
            "input": "We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.",
            "output": [
                "oxaliplatin"
            ]
        },
        {
            "id": "task1447-768d3fa33fff4d7488454bc9c7151730",
            "input": "An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.",
            "output": [
                "clofazimine"
            ]
        },
        {
            "id": "task1447-a19ce5ea87a84f0c97ba6ca4db9000ea",
            "input": "Clofazimine enteropathy in a pediatric bone marrow transplant recipient.",
            "output": [
                "Clofazimine"
            ]
        },
        {
            "id": "task1447-a48757483ea74022bb0c776687ffd1b7",
            "input": "She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.",
            "output": [
                "Enoxaparin"
            ]
        },
        {
            "id": "task1447-132d6a71d8b545398b990227588346d3",
            "input": "Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-e52dfd5bf4aa4ee381ad5d632c69a456",
            "input": "We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-2ce6a6b45e2c4b8d818b7afdbce80463",
            "input": "CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-7083953592cd4c0fa4518f836c79bfad",
            "input": "Increased libido in a woman treated with fluvoxamine: a case report.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-cbd62659ef594097a787864180f12fde",
            "input": "OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-9f57dcd04bcb442cade504b094615485",
            "input": "RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-af619429d9114c52afefee19ad093f0a",
            "input": "The increased libido disappeared after fluvoxamine was discontinued.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-a014631071164299b183cf4d6219a624",
            "input": "An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.",
            "output": [
                "meglumine antimoniate"
            ]
        },
        {
            "id": "task1447-45125579103b4e818e6ecf727654f4ad",
            "input": "Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.",
            "output": [
                "meglumine antimoniate"
            ]
        },
        {
            "id": "task1447-cd4e9e78c82d48fd98d43136a0e0e72e",
            "input": "CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-af6a358cc1484ff5bffb75e585b70c35",
            "input": "Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-624a23f9d8c64490832f46c523cdc45d",
            "input": "Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.",
            "output": [
                "levodopa"
            ]
        },
        {
            "id": "task1447-b69744a986154d8ca2941a2881e5bff9",
            "input": "CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-6a97f5b8d2a14fe2b917df2823485bc7",
            "input": "Leflunomide-associated weight loss in rheumatoid arthritis.",
            "output": [
                "Leflunomide"
            ]
        },
        {
            "id": "task1447-fc4d3b6a8329455d83d610d30d7f7726",
            "input": "METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-4e74ed7fc4564c0e98d553d0339af8b7",
            "input": "OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-6105a0f498ed4a0b9b8ef6708835453d",
            "input": "RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-28e1e547e16043c6b01633e29681508b",
            "input": "It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.",
            "output": [
                "valacyclovir"
            ]
        },
        {
            "id": "task1447-5e106ef137804d0386ca07e738542f51",
            "input": "Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.",
            "output": [
                "valacyclovir"
            ]
        },
        {
            "id": "task1447-be6a38341cd749daad5c5e31a9fc2b60",
            "input": "She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.",
            "output": [
                "valacyclovir"
            ]
        },
        {
            "id": "task1447-a9494ca72da34432b3b5e4154b33d799",
            "input": "Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-91f963a220964f6ea07a7ef8767d2dcd",
            "input": "We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-700b64d79f354d3ab030a8c7db20beca",
            "input": "Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.",
            "output": [
                "Levofloxacin"
            ]
        },
        {
            "id": "task1447-45e1fa91cdf24aa3a894deb1968c9935",
            "input": "We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.",
            "output": [
                "levofloxacin"
            ]
        },
        {
            "id": "task1447-4c9b876856434f928183f441d42c0a5d",
            "input": "So far, few cases of pulmonary side effects caused by ticlopidine have been reported.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-a3484d2f7abd43e88fc61d5c059501fe",
            "input": "Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-ff309f389e7d4ace8f6cb03cb1e99968",
            "input": "Ticlopidine-induced interstitial pulmonary disease: a case report.",
            "output": [
                "Ticlopidine"
            ]
        },
        {
            "id": "task1447-31710c0ac8764e1abbfd117446e67aee",
            "input": "A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.",
            "output": [
                "methadone"
            ]
        },
        {
            "id": "task1447-da3c01a4f5ed476898af811456669427",
            "input": "Methadone-induced myoclonus in advanced cancer.",
            "output": [
                "Methadone"
            ]
        },
        {
            "id": "task1447-c6c7ac8ddd61498e84377be41c555e85",
            "input": "OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.",
            "output": [
                "succinylcholine"
            ]
        },
        {
            "id": "task1447-9ba53dacd6584b09be94d8d0ed843d05",
            "input": "Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.",
            "output": [
                "Succinylcholine"
            ]
        },
        {
            "id": "task1447-ee4bd3d9cc1846cb8954adf79e14b81e",
            "input": "We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.",
            "output": [
                "succinylcholine"
            ]
        },
        {
            "id": "task1447-905f04027f5e46498480dcf9f4d293ee",
            "input": "Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.",
            "output": [
                "ethanol injection"
            ]
        },
        {
            "id": "task1447-d7ecc3b257b14b19a426e036b2c14afa",
            "input": "We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).",
            "output": [
                "ethanol injection"
            ]
        },
        {
            "id": "task1447-56eea56f736549b883b1984e3dfe2910",
            "input": "Adenosine-induced ventricular fibrillation.",
            "output": [
                "Adenosine"
            ]
        },
        {
            "id": "task1447-567d8af685b047e5a93892afbcf16c5d",
            "input": "However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-f3e4966d3528481184f11f8852ae5e4e",
            "input": "We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-3c35447743c34735b3d5456070320dc0",
            "input": "After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-a82cb6a732594ba4b314cf42e376b8b8",
            "input": "Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.",
            "output": [
                "CBZ"
            ]
        },
        {
            "id": "task1447-ba31997fe2b14e0081c97a24efcb2690",
            "input": "We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.",
            "output": [
                "didanosine"
            ]
        },
        {
            "id": "task1447-6e3abd365ae441a2afa3acc3bee79396",
            "input": "This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.",
            "output": [
                "dexamethasone"
            ]
        },
        {
            "id": "task1447-d01fed56e3374aa3bb8fb8b98f25fc26",
            "input": "Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-638c2d74803943d7815bdfc829f29091",
            "input": "An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-bb3c165cf87c4cb380cc9838126f984f",
            "input": "Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-efe433366fa54563b0a7305c733cebd8",
            "input": "Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.",
            "output": [
                "amprenavir"
            ]
        },
        {
            "id": "task1447-33dbe5fac7344ca79aeabb8710952f57",
            "input": "The bleeding resolved on discontinuation of APV.",
            "output": [
                "APV"
            ]
        },
        {
            "id": "task1447-a11f0376edaf454fa12d8819d2e863eb",
            "input": "We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).",
            "output": [
                "amprenavir"
            ]
        },
        {
            "id": "task1447-ccbd73c67ef5425c8f158d555c017089",
            "input": "According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-6d529844b07e4b7d89c910baef0d8dcd",
            "input": "CONCLUSIONS: We report the first case of gemcitabine-induced LABD.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-6e81f243c2a74260a2cbbd9029b93655",
            "input": "Linear immunoglobulin A bullous dermatosis induced by gemcitabine.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-2c945aaebbf3490d8424edf6b4896ffa",
            "input": "Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-c9fab41236fe418b89d8505342bce0a2",
            "input": "Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.",
            "output": [
                "Vancomycin"
            ]
        },
        {
            "id": "task1447-397da15103cd4116974d42abe8398db2",
            "input": "Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.",
            "output": [
                "taxol"
            ]
        },
        {
            "id": "task1447-ad6bb54a586b4c73a1077d7b48025d8a",
            "input": "A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.",
            "output": [
                "paclitaxel"
            ]
        },
        {
            "id": "task1447-0450d7f6e36d48b3a58371dc1ab8fb7b",
            "input": "Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-1651900cfbab472ca90dc45f812523cc",
            "input": "Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-6972bb49bd474fb38e776e15f2e13bad",
            "input": "A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.",
            "output": [
                "sodium aurothiomalate"
            ]
        },
        {
            "id": "task1447-ab266aa2dde94bb1b72d85bdcdbe6925",
            "input": "BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.",
            "output": [
                "Accutane"
            ]
        },
        {
            "id": "task1447-eef5f95e599947b0911ee6114e0964fb",
            "input": "RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.",
            "output": [
                "Accutane"
            ]
        },
        {
            "id": "task1447-b03cac0125af4133a4e42cc75cca8d6b",
            "input": "An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.",
            "output": [
                "indinavir"
            ]
        },
        {
            "id": "task1447-1e43d70e27594cf19816fdabd4162e89",
            "input": "Papillary necrosis associated with the HIV protease inhibitor indinavir.",
            "output": [
                "indinavir"
            ]
        },
        {
            "id": "task1447-fa476fa104ac497d96563072f5f84aa6",
            "input": "The renal consequences of indinavir-associated nephrotoxicity are uncertain.",
            "output": [
                "indinavir"
            ]
        },
        {
            "id": "task1447-2ac9dee943b94e47b097bed2b9d30666",
            "input": "We report a case of papillary necrosis in a patient treated with indinavir.",
            "output": [
                "indinavir"
            ]
        },
        {
            "id": "task1447-9461b2dec2f8458898731ea732efd6cf",
            "input": "We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.",
            "output": [
                "rofecoxib"
            ]
        },
        {
            "id": "task1447-4496da05416942eab59f3d699042c249",
            "input": "CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.",
            "output": [
                "LTG"
            ]
        },
        {
            "id": "task1447-3fad90e684cb4fc39b32a437cae3540c",
            "input": "Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.",
            "output": [
                "LTG"
            ]
        },
        {
            "id": "task1447-cda02c32a852448da0dbf7fa98e6884b",
            "input": "PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-cd729d4584ad404abe6114fb3fc14b27",
            "input": "Stupor from lamotrigine toxicity.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-81b0432e76a34366b30f7c26314011c4",
            "input": "The cause of death was determined to be acute intoxication by olanzapine, and the manner of death was accidental.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-e8578d710c574306a8b42275e2a9eb02",
            "input": "This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-685a4dfe0ffb462eb847f0f3853fc37f",
            "input": "Lichenoid drug eruption to salsalate.",
            "output": [
                "salsalate"
            ]
        },
        {
            "id": "task1447-5acbf2642ae34eadbe04bdc7e7db71e8",
            "input": "This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.",
            "output": [
                "salsalate"
            ]
        },
        {
            "id": "task1447-1e420e0b7b0042d0bd0ca7e09bb499d7",
            "input": "We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.",
            "output": [
                "salsalate"
            ]
        },
        {
            "id": "task1447-627fc57d49de4b4188f7791c81c62f74",
            "input": "Amphotericin B-induced seizures in a patient with AIDS.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-d3718ce7da0c406fa03902fef6192f76",
            "input": "CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-56b099e3118249b1a3cfbb1278c2292b",
            "input": "CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-6fbca8caa23c430b9ae4d6a37906b893",
            "input": "Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.",
            "output": [
                "amphotercin B"
            ]
        },
        {
            "id": "task1447-63bdab088a16471a8ec316af3beb5e91",
            "input": "Didanosine also has a potential for inducing seizures.",
            "output": [
                "Didanosine"
            ]
        },
        {
            "id": "task1447-68fcf920e8b34fb8bfaea6c253b18b7f",
            "input": "OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-9640288028134863a835d3a05f139593",
            "input": "The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-7ef875a5996c45ca98fdf798e3eaf0a2",
            "input": "To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-f701568839b24d0fa93cb5563b4cce53",
            "input": "Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.",
            "output": [
                "bupivacaine"
            ]
        },
        {
            "id": "task1447-83537b60f7b64bf9bb8f88bb35a1c35e",
            "input": "We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.",
            "output": [
                "bupivacaine"
            ]
        },
        {
            "id": "task1447-568ce79147e74e5ba1ca889a5f91dcc8",
            "input": "A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-eb4dd36cccf2424aa37b5dd64b971631",
            "input": "Carbamazepine induced right bundle branch block in a Greenlandic patient.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-269aaf7c50a5415ab3c1ac9b9c562bd5",
            "input": "Cicatricial entropion associated with chronic dipivefrin application.",
            "output": [
                "dipivefrin"
            ]
        },
        {
            "id": "task1447-2e72623d929345b795272c572a21fc94",
            "input": "CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.",
            "output": [
                "dipivefrin"
            ]
        },
        {
            "id": "task1447-356162faaa734740880a947566208cd6",
            "input": "Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.",
            "output": [
                "dipivefrin"
            ]
        },
        {
            "id": "task1447-f6a069c2b83f4a5282d5ec92e2671691",
            "input": "PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.",
            "output": [
                "dipivefrin"
            ]
        },
        {
            "id": "task1447-21294a10822e41749a73d54f9b700192",
            "input": "The 3-week sulphasalazine syndrome strikes again.",
            "output": [
                "sulphasalazine"
            ]
        },
        {
            "id": "task1447-050bb52aa5f94ebaac7ebc711c27279b",
            "input": "Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.",
            "output": [
                "CDDP"
            ]
        },
        {
            "id": "task1447-c45a37f083204c35968b066fb7e891bc",
            "input": "After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.",
            "output": [
                "scopolamine"
            ]
        },
        {
            "id": "task1447-638fec6ceb0742ffb51eef6d22d16e1a",
            "input": "Anisocoria from transdermal scopolamine.",
            "output": [
                "scopolamine"
            ]
        },
        {
            "id": "task1447-7cbb1bbcf24a4992a2984d4365dee76c",
            "input": "De novo absence status of late onset following withdrawal of lorazepam: a case report.",
            "output": [
                "lorazepam"
            ]
        },
        {
            "id": "task1447-996eaa028124433aaa93be3825a851c7",
            "input": "The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.",
            "output": [
                "lorazepam"
            ]
        },
        {
            "id": "task1447-164a46efccca47b4babef2de0a8b6ced",
            "input": "Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-89a4cedd8ae24982b37d6463c8bfb2dd",
            "input": "Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-5738536ecb0d408ebab7e9269e5aef6b",
            "input": "The disease predisposes to severe vincristine neurotoxicity.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-5594674978ba469ea6e2058c6354f2e0",
            "input": "We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-e6915f1028894f16bf3e01d61bac0061",
            "input": "We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.",
            "output": [
                "8-MOP"
            ]
        },
        {
            "id": "task1447-8f6286c9359743cf85bef36f7e3337ee",
            "input": "CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-ad53be544e514e8a90c1bb84f79a37e0",
            "input": "METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-80a8f44cef774cf3a75e3dbbdb6cf915",
            "input": "CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-a331ae2ff5a5450cabf5dd62f814a6ae",
            "input": "It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-28c1e7b3ffba42eb87226dd2a6516403",
            "input": "OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-883ad2344ca045e38cd241bea7638676",
            "input": "Ofloxacin: a probable cause of toxic epidermal necrolysis.",
            "output": [
                "Ofloxacin"
            ]
        },
        {
            "id": "task1447-aa589e5a8e404bada313e050d29ab75b",
            "input": "A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.",
            "output": [
                "G-CSF"
            ]
        },
        {
            "id": "task1447-3474d0f2c5ca47bb9d900becb98e0e2a",
            "input": "A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.",
            "output": [
                "G-CSF"
            ]
        },
        {
            "id": "task1447-95b02a856d214a2381265fb9e9bc7919",
            "input": "There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.",
            "output": [
                "liothyronine"
            ]
        },
        {
            "id": "task1447-41680e8f16c64b2192d9bb8e0e18a35b",
            "input": "Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease.",
            "output": [
                "Triiodothyronine"
            ]
        },
        {
            "id": "task1447-96ab03ad25ce47a594fe5713642a0259",
            "input": "Pulmonary toxicity with mefloquine.",
            "output": [
                "mefloquine"
            ]
        },
        {
            "id": "task1447-97caa0cf7ee04351bac742fa51c1bfba",
            "input": "This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",
            "output": [
                "mefloquine"
            ]
        },
        {
            "id": "task1447-fd92c5cae49348438c59efda1d653e7d",
            "input": "An adult male presented with central blindness after ingesting methanol.",
            "output": [
                "methanol"
            ]
        },
        {
            "id": "task1447-25bb26873ff54c88a61681327383468c",
            "input": "Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.",
            "output": [
                "methanol"
            ]
        },
        {
            "id": "task1447-bdc34a1ae3724bb7ac9ced6d652eaf37",
            "input": "Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-461d1ffc8d4440a396237f0ead79c4a9",
            "input": "Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-7aa2f7bad816462fbe83e587de66a9d1",
            "input": "This is the first reported case of hepatolithiasis during octreotide therapy.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-0da5fe67547d414fb962797d4ca1b1cc",
            "input": "We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-f4903192061849069d2953ab2aec63f2",
            "input": "However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-0fdcea493ec34ca8a65545cd086c85c0",
            "input": "In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-81915a2dfb1d41b585f8a4aee8abc659",
            "input": "INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.",
            "output": [
                "INH"
            ]
        },
        {
            "id": "task1447-db7083496e604d0abe015c85deb893c3",
            "input": "Linear IgA bullous dermatosis occurring after carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-147014cbdd3047a18f2a061e84a59ca5",
            "input": "We report a patient who experienced LABD shortly after starting carbamazepine therapy.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-13d56d68ca49417cad0eccf117463551",
            "input": "Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-ce87f1cb91524ee8a31be12094f25e1d",
            "input": "A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-3219e4631b5b451d8b62da568e3b8ba1",
            "input": "BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-5a3f0a0200c8435dab48e16b546a6deb",
            "input": "Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-73f85ae31fca4e0ca4a16d8e96d38218",
            "input": "Dermatitis to captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-2d8452c3410748d2825f1c7ffd91fa25",
            "input": "We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-b3bf3ed976664b9ea64ee985318006c9",
            "input": "A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-1eb91854e1824612b0f3a8f96daa790d",
            "input": "Warfarin-associated bleeding complication saved life.",
            "output": [
                "Warfarin"
            ]
        },
        {
            "id": "task1447-93954b490d4142cf90708a53f8c4b4aa",
            "input": "Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.",
            "output": [
                "Warfarin"
            ]
        },
        {
            "id": "task1447-6cc51b8d1ac54c8695553dae6a073c3d",
            "input": "Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-8d03b79f610f499f9ef1645dfc196b86",
            "input": "To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-564a20c8a29a42bb8dfbc4ee60d31cc9",
            "input": "Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.",
            "output": [
                "ethanol"
            ]
        },
        {
            "id": "task1447-67573afa25694e25a6829007fb88fd8a",
            "input": "We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.",
            "output": [
                "ethanol"
            ]
        },
        {
            "id": "task1447-a81de582e3d246349c29172d77a7e690",
            "input": "Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-c585ad7160cb416f881c1c3c6db4abee",
            "input": "We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-0f13a826fde54c9b94c5164885ee2084",
            "input": "Hepatotoxicity related to itraconazole: report of three cases.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-d03142fa88e8463e95dc8b4e7a513166",
            "input": "METHODS: Three patients with apparent itraconazole-induced liver injury were studied.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-b10e998bf17341fcb940672fb18dc471",
            "input": "The occurrence of acute hepatitis is best known for ketoconazole.",
            "output": [
                "ketoconazole"
            ]
        },
        {
            "id": "task1447-7a0ad50901b14d07975f6f30fff2686a",
            "input": "We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-33c5dd3b7f93454a84688c8a6d443810",
            "input": "We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-ca2f14e18db44d1884192e6d9f247fe5",
            "input": "With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-67aa5532d8b6407daef644fd9321cb1f",
            "input": "Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.",
            "output": [
                "porcine factor VIII"
            ]
        },
        {
            "id": "task1447-ce11c4b420e54929b4970237b1172df6",
            "input": "We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.",
            "output": [
                "pFVIII"
            ]
        },
        {
            "id": "task1447-3685905afdd14ce1908706a4f312e4d6",
            "input": "We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.",
            "output": [
                "pFVIII"
            ]
        },
        {
            "id": "task1447-93d2eb67cca54fb2935098961fbcbfa4",
            "input": "CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.",
            "output": [
                "mirtazapine"
            ]
        },
        {
            "id": "task1447-3b11c05cfb5f488e84de350232dfaee9",
            "input": "DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.",
            "output": [
                "mirtazapine"
            ]
        },
        {
            "id": "task1447-0dd5c5696fbd42e8ae33e764e288271a",
            "input": "Severe serotonin syndrome induced by mirtazapine monotherapy.",
            "output": [
                "mirtazapine"
            ]
        },
        {
            "id": "task1447-953fcf4b5b72421f99376a3e1d8dad5c",
            "input": "Pulmonary toxicity secondary to procarbazine.",
            "output": [
                "procarbazine"
            ]
        },
        {
            "id": "task1447-08b671a5112742718ba390e52dbb0022",
            "input": "A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.",
            "output": [
                "interferon (IFN)-beta"
            ]
        },
        {
            "id": "task1447-caff5b649fe543069812ff0b5c4ee7ad",
            "input": "Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.",
            "output": [
                "interferon-beta"
            ]
        },
        {
            "id": "task1447-f4661c35d5fe4eea9b57793e01b84530",
            "input": "To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.",
            "output": [
                "IFN-beta"
            ]
        },
        {
            "id": "task1447-85e44789713a4a508314a4a10acea801",
            "input": "CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.",
            "output": [
                "lansoprazole"
            ]
        },
        {
            "id": "task1447-e1f9f0c635654acab10add6d4b366897",
            "input": "He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).",
            "output": [
                "lansoprazole"
            ]
        },
        {
            "id": "task1447-fb07cde576534d67ad44d636ea62ca4c",
            "input": "Lansoprazole-induced thrombocytopenia.",
            "output": [
                "Lansoprazole"
            ]
        },
        {
            "id": "task1447-a757efc437904cbb99d977034f7d0802",
            "input": "OBJECTIVE: To describe a case of thrombocytopenia associated with the administration of lansoprazole.",
            "output": [
                "lansoprazole"
            ]
        },
        {
            "id": "task1447-29d3828a15cd4dbeae338e86fce90ec9",
            "input": "To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.",
            "output": [
                "lansoprazole"
            ]
        },
        {
            "id": "task1447-51d3dd6bb0b842c39ec1d2e901476b84",
            "input": "Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.",
            "output": [
                "amifostine"
            ]
        },
        {
            "id": "task1447-41e726592cdb4ebaba506290549aeb4c",
            "input": "The patient suffered a life-threatening anaphylactoid reaction to amifostine.",
            "output": [
                "amifostine"
            ]
        },
        {
            "id": "task1447-0270e573e56c45d19a34deb87722238f",
            "input": "Agranulocytosis during clozapine therapy.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-7b356639695844e8b000041d60d35ca6",
            "input": "The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-5bc6975d8cea45d6b13c8e5a411803ee",
            "input": "The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-5ec7b2180ab54d449ba2f1df3bdc7c15",
            "input": "A 53-year-old man developed NMS without rigidity while taking olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-47613503b86c4e8285d18702c3d72da3",
            "input": "Atypical neuroleptic malignant syndrome associated with olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-b7394c4a401e4261991eaba336627fd7",
            "input": "CASE SUMMARY: We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-2537cc436b3b41c5a40e34af495e5a25",
            "input": "CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-027ffee8d0af4c9f899d122da1778b21",
            "input": "DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-233805382a6742289851cb5214860c62",
            "input": "OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-862a1d11435c4c7baf404df7a0753db2",
            "input": "Priapism associated with zuclopenthixol.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-00d8ed39fc7247138c424b8d03f54aaf",
            "input": "The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.",
            "output": [
                "zuclopenthixol"
            ]
        },
        {
            "id": "task1447-770277036ab14071895de1218a6b0f9e",
            "input": "After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.",
            "output": [
                "metamizole"
            ]
        },
        {
            "id": "task1447-2593a598e9a74fc996de0e91f8d12509",
            "input": "Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.",
            "output": [
                "Metamizole"
            ]
        },
        {
            "id": "task1447-dad0dc979305428bab1ad3e41d7de764",
            "input": "Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.",
            "output": [
                "mitomycin"
            ]
        },
        {
            "id": "task1447-3791ed3592234a96b7975b537c7f53bd",
            "input": "We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.",
            "output": [
                "mitomycin C"
            ]
        },
        {
            "id": "task1447-760f04c5a2c1442db26fd4cfe5462777",
            "input": "Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.",
            "output": [
                "Levofloxacin"
            ]
        },
        {
            "id": "task1447-184a752613504a3298f28ea77a587681",
            "input": "To our knowledge, this case is the first published report of levofloxacin-induced TEN.",
            "output": [
                "levofloxacin"
            ]
        },
        {
            "id": "task1447-cc918f75bbda4b5fa00a6748de53b99d",
            "input": "OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.",
            "output": [
                "IL-2"
            ]
        },
        {
            "id": "task1447-a92e973e2a834a45976c889117c18389",
            "input": "Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.",
            "output": [
                "IL-2"
            ]
        },
        {
            "id": "task1447-3cabb5ef998d4749a3b3a2fcdea55099",
            "input": "Toxic epidermal necrolysis associated with interleukin-2.",
            "output": [
                "interleukin-2"
            ]
        },
        {
            "id": "task1447-291c8657b1d74aef826fb4f888f08084",
            "input": "A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.",
            "output": [
                "Gelofusine"
            ]
        },
        {
            "id": "task1447-86e5265022b24d9784bae37670b1c052",
            "input": "Gelofusine allergy--the need for identification jewellery.",
            "output": [
                "Gelofusine"
            ]
        },
        {
            "id": "task1447-ba4385374571496ab748c2a6918ae95d",
            "input": "Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-b2747e874e784988856fe53c0e40dea1",
            "input": "To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-dbd461ec45b84181938c59dc33a079f0",
            "input": "Epoprostenol may be associated rarely with severe erythroderma.",
            "output": [
                "Epoprostenol"
            ]
        },
        {
            "id": "task1447-fb1d7d1a48104dedb430e37b9b821c50",
            "input": "Severe erythroderma as a complication of continuous epoprostenol therapy.",
            "output": [
                "epoprostenol"
            ]
        },
        {
            "id": "task1447-094562fa693c4c7a8cb872ce22571501",
            "input": "A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-5276079ae53a40f5894c894e56664c03",
            "input": "There is no consensus on the treatment of ticlopidine-induced marrow aplasia.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-e1a29d0641374d879874a3c87854edd0",
            "input": "Ticlopidine-induced marrow aplasia treated with cyclosporine.",
            "output": [
                "Ticlopidine"
            ]
        },
        {
            "id": "task1447-db8770ded62e4e0daa480e6b8c0165e6",
            "input": "A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.",
            "output": [
                "rosiglitazone"
            ]
        },
        {
            "id": "task1447-c4b64461955444a986dfeff2e6437f64",
            "input": "A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.",
            "output": [
                "pioglitazone"
            ]
        },
        {
            "id": "task1447-bbd83e017a2f42c1bd64859148afa444",
            "input": "A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.",
            "output": [
                "rosiglitazone"
            ]
        },
        {
            "id": "task1447-8d11178e19d0456c8d1e7cb59396ccdb",
            "input": "Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-e4da0051810940c1af7985a7d839d083",
            "input": "Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.",
            "output": [
                "Verapamil"
            ]
        },
        {
            "id": "task1447-c726c84f6aa14228ac016a5323186e9b",
            "input": "We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-b65cc61ba28c47aa972fdc5d31522d2e",
            "input": "Epsilon-aminocaproic acid and renal complications: case report and review of the literature.",
            "output": [
                "Epsilon-aminocaproic acid"
            ]
        },
        {
            "id": "task1447-8f0d6ec0ffc047e6b495ba1cca33b450",
            "input": "Neonatal mydriasis: intravenous lidocaine adverse reaction.",
            "output": [
                "lidocaine"
            ]
        },
        {
            "id": "task1447-4b8b7cdfe1954401b56a90b5cb2126a6",
            "input": "We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.",
            "output": [
                "lidocaine"
            ]
        },
        {
            "id": "task1447-709130ff861045d8a0f1834ba6dd4ea7",
            "input": "We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.",
            "output": [
                "lidocaine"
            ]
        },
        {
            "id": "task1447-d73491f597cc4d42a78ed22af6063023",
            "input": "To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.",
            "output": [
                "2-chlorodeoxyadenosine"
            ]
        },
        {
            "id": "task1447-4c54c10fb62d40e2814002691c2196e7",
            "input": "CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-3d50570b87104df2a2cfdfe7d0a890c8",
            "input": "OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-776718ed69894064a572221ddba56e64",
            "input": "Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-06215dc896a54f77b1e6893099a9a237",
            "input": "Mitomycin-C induced hemolytic uremic syndrome: a case report.",
            "output": [
                "Mitomycin-C"
            ]
        },
        {
            "id": "task1447-c4e32c4eb4674e988e3e0cfaa4ef561c",
            "input": "Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.",
            "output": [
                "Mitomycin-C"
            ]
        },
        {
            "id": "task1447-d920b04f9d6a423f90905c912c9acc57",
            "input": "Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.",
            "output": [
                "cladribine"
            ]
        },
        {
            "id": "task1447-b77d3422ad0740c187d21a1049403feb",
            "input": "Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.",
            "output": [
                "cladribine"
            ]
        },
        {
            "id": "task1447-3affa2fb33a444fca0a5bcf3c9695cdc",
            "input": "Gigantomastia induced by bucillamine.",
            "output": [
                "bucillamine"
            ]
        },
        {
            "id": "task1447-a2ea1aee1dc247ceb171de26fab5f766",
            "input": "The authors report the first case of bucillamine-induced giant mammary hyperplasia.",
            "output": [
                "bucillamine"
            ]
        },
        {
            "id": "task1447-3aba72d9c97648f8b74eee0964a8403e",
            "input": "The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-8bd53696169149c99c66c1789248312c",
            "input": "Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.",
            "output": [
                "Valproate"
            ]
        },
        {
            "id": "task1447-4a380756e7f24f50a58af0c743503d9a",
            "input": "Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.",
            "output": [
                "cyclosporin a"
            ]
        },
        {
            "id": "task1447-778f2c388c8d4b5495d7a43eb478ee62",
            "input": "The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-8fe254c2a7c1457da800f2bf14cd3fea",
            "input": "Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.",
            "output": [
                "Ticlopidine"
            ]
        },
        {
            "id": "task1447-ce38d374014d4b8d977a4d14cd31064a",
            "input": "When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.",
            "output": [
                "ticlopidine"
            ]
        },
        {
            "id": "task1447-4c518d2d53bd433d8e21d2e0675b80f4",
            "input": "Fixed drug eruption to rofecoxib.",
            "output": [
                "rofecoxib"
            ]
        },
        {
            "id": "task1447-7e3f7890c09d48d99b086418ecbbc0e5",
            "input": "A patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal.",
            "output": [
                "thyroid hormone"
            ]
        },
        {
            "id": "task1447-9cfa8062144d45bfbdee0d001cd8bcce",
            "input": "CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-751ac28c69e1425daf399502e698f538",
            "input": "Gemcitabine-associated hemolytic-uremic syndrome.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-b16f78e1be874bf0816e3d0f232c1314",
            "input": "METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-99b96d5ec53b41689062b7db2ea0335b",
            "input": "RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-9f1e30aea0eb4d5690121881ff78c7b8",
            "input": "An amiodarone optic neuropathy has been described.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-c11cd160948a422ca2499a6032527a03",
            "input": "Biomicroscopy revealed amiodarone corneal deposits.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-fb4fc0b7f46b4f7ab7be423259b34c18",
            "input": "Visual changes secondary to initiation of amiodarone: a case report and review involving ocular management in cardiac polypharmacy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-8b259e96b40d4804940650934eb3809b",
            "input": "CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-a1c8f43a14364220910581f0b3591a79",
            "input": "We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-c8882689c1ed42189c5443fbecbad3ff",
            "input": "A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.",
            "output": [
                "nefazodone"
            ]
        },
        {
            "id": "task1447-910fbefd4fff44718b3fa5ea695495c5",
            "input": "A case of SIADH induced by mizoribin administration.",
            "output": [
                "mizoribin"
            ]
        },
        {
            "id": "task1447-5bf270c8ada04ce4bb4368a93c8c4649",
            "input": "Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-6ca61053c7ea45a88c19c659f607f735",
            "input": "We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-120b942468bd4c11bf258089e3f473bd",
            "input": "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.",
            "output": [
                "interferon beta-1a"
            ]
        },
        {
            "id": "task1447-a7d0eaa2961e493485f136266c90b640",
            "input": "Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.",
            "output": [
                "Carboplatin"
            ]
        },
        {
            "id": "task1447-7d480d0aee8c4afc83b6e52e3a261722",
            "input": "Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.",
            "output": [
                "Capecitabine"
            ]
        },
        {
            "id": "task1447-b468e3488160417eaffeb3369f8905fd",
            "input": "CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-f5e3692d561c46a881eda9d3216f22cf",
            "input": "Fluorouracil for allergic reactions to capecitabine.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-db52a05c5250467ea25e2af4d9db46d0",
            "input": "It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-d5f791c7a82e4af4b43774192eb746b4",
            "input": "OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-cbc56ef07f064432bdb6f4079afcfde2",
            "input": "After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-8536a1f60e264990b29d2d12a04ff5e4",
            "input": "Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-4d731fe64a8e4458ab73934076bbf3c4",
            "input": "Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.",
            "output": [
                "cytarabine"
            ]
        },
        {
            "id": "task1447-9df11e8840b242bda78e93872f27e807",
            "input": "It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.",
            "output": [
                "cytarabine"
            ]
        },
        {
            "id": "task1447-dad2ecff6d324df4a02b1c7df2fdc4f0",
            "input": "Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.",
            "output": [
                "cytarabine"
            ]
        },
        {
            "id": "task1447-daef1a7bb65f4d1b8dd3266b1ffe4d95",
            "input": "Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-43ead2588a8349d4bdaed6de65b43d6f",
            "input": "BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-58b783eb3f5c47cea32afd901a684690",
            "input": "CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.",
            "output": [
                "Tamoxifen"
            ]
        },
        {
            "id": "task1447-ea47ee68b4c146c895190cac25f72cee",
            "input": "Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-cd23590e77c74eeda89507e9329c7a36",
            "input": "Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.",
            "output": [
                "metronidazole"
            ]
        },
        {
            "id": "task1447-e689cfd9b75548afaefdd2a7223ae21b",
            "input": "Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.",
            "output": [
                "metronidazole"
            ]
        },
        {
            "id": "task1447-fd32dc53d29f4cec95c12e34c5e770ba",
            "input": "Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.",
            "output": [
                "metronidazole"
            ]
        },
        {
            "id": "task1447-e3c9ec1ff9bc4ca199ca154bd21171f6",
            "input": "After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-75d27c2785ee49fd9e5856ed2c7b2aca",
            "input": "Anaphylaxis to cisplatin following nine previous uncomplicated cycles.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-9625cf092ff34b8d9ced4644a454ca3e",
            "input": "Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-ead643d3ef2b4d969f101c7562638606",
            "input": "Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.",
            "output": [
                "isradipine"
            ]
        },
        {
            "id": "task1447-57498004192f4f74ae8261a36f58c43f",
            "input": "CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.",
            "output": [
                "clarithromycin"
            ]
        },
        {
            "id": "task1447-f5282c9c6e97462ab09a8a8104be1e3a",
            "input": "CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.",
            "output": [
                "Clarithromycin"
            ]
        },
        {
            "id": "task1447-95ec3a8262034773af7fc5bb3fb66404",
            "input": "Fulminant liver failure associated with clarithromycin.",
            "output": [
                "clarithromycin"
            ]
        },
        {
            "id": "task1447-5fdfb06d13dc4a609be7bc8faf3340a1",
            "input": "OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.",
            "output": [
                "clarithromycin"
            ]
        },
        {
            "id": "task1447-c90f09b54d1c4c22ac8559487aa6959e",
            "input": "A paradoxical ocular effect of brimonidine.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-4b4a713ad5b6406daf478c0797f3e33c",
            "input": "CONCLUSION: Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-def0fffbc97c4779bc5ca547ff95bb91",
            "input": "PURPOSE: We report an unusual paradoxical effect of brimonidine.",
            "output": [
                "brimonidine"
            ]
        },
        {
            "id": "task1447-8ec3a3ccce6a4aa4af95f99310523c3e",
            "input": "RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.",
            "output": [
                "Brimonidine"
            ]
        },
        {
            "id": "task1447-4eca3507953449aba4f75dc8cc40832e",
            "input": "Gabapentin withdrawal presenting as status epilepticus.",
            "output": [
                "Gabapentin"
            ]
        },
        {
            "id": "task1447-ee90532f26cd4575bef1c1d44aa4423b",
            "input": "Visual hallucinations associated with zonisamide.",
            "output": [
                "zonisamide"
            ]
        },
        {
            "id": "task1447-9add4082eaa649a79084efdae4ede490",
            "input": "Doxycycline-induced hypoglycemia in a nondiabetic young man.",
            "output": [
                "Doxycycline"
            ]
        },
        {
            "id": "task1447-957a0639c0d543758851fa26fdc44ced",
            "input": "We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.",
            "output": [
                "doxycycline"
            ]
        },
        {
            "id": "task1447-9dd65ffce4cf4ee1a93c4e8de92365b4",
            "input": "For patients who suffer from osteogenic sarcoma and have anaphylactic reactions to MTX, this desensitization protocol will allow these patients to continue with needed therapeutic or palliative chemotherapy.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-c989d997d9ba45c6a9e0831a2f2850d6",
            "input": "He was later skin tested to confirm allergy to MTX.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-cf3303151ce04bab9e261bb7a64782ad",
            "input": "Successful desensitization to high-dose methotrexate after systemic anaphylaxis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-ad5f9f784a194686ab95bb1d60a9f18f",
            "input": "The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-08a36adb353942f5a0cd49b27a437791",
            "input": "We present a unique case of GTBM in a patient with myeloma following treatment with Melphalan.",
            "output": [
                "Melphalan"
            ]
        },
        {
            "id": "task1447-e8202d829b2340438abc2281d1aec474",
            "input": "Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-0fcec52cf5024abbb1f2c76d5601c576",
            "input": "Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.",
            "output": [
                "6-thioguanine"
            ]
        },
        {
            "id": "task1447-5f8b29d8fd5d44a5a57a471f40e0b0ef",
            "input": "This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.",
            "output": [
                "thiopurine"
            ]
        },
        {
            "id": "task1447-4feecea76ae74c36873dfae66116271e",
            "input": "We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.",
            "output": [
                "6-TG"
            ]
        },
        {
            "id": "task1447-9d237801aee24c17be655e087873e5e9",
            "input": "Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.",
            "output": [
                "lisinopril"
            ]
        },
        {
            "id": "task1447-f76e156b7ab242809aaa2be5ea93a71e",
            "input": "Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-87ad13172eb54286bf66e9a599f064b8",
            "input": "The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-fafbbe08738f4e039c5b2df2a7b269df",
            "input": "This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-e5bea0a6db714852a7044b3c2fe8c009",
            "input": "Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-cecbe746c58042f683be62cbd108a126",
            "input": "Clozapine-induced akathisia in children with schizophrenia.",
            "output": [
                "Clozapine"
            ]
        },
        {
            "id": "task1447-edfa9e76d011417b94901b136223d0d2",
            "input": "Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-9d1f963c43bf4115b282d776de1d115b",
            "input": "Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-f22c09d37ddb4a8599d3a91c1a4d07a4",
            "input": "Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-882ad48010f44cf0b36773ad29a5928f",
            "input": "Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-fdb66f72954f499e8b70e0e8cedda2a0",
            "input": "There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-b21d86eef370400fa4fea4b620df4116",
            "input": "His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity.",
            "output": [
                "chloroquine"
            ]
        },
        {
            "id": "task1447-49e6cbea38a441d5b40eb3b1f81d55c8",
            "input": "OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.",
            "output": [
                "chloroquine"
            ]
        },
        {
            "id": "task1447-81da4f5a7fa14018823b9e9f27d2ac9e",
            "input": "Toxicity related to chloroquine treatment of resistant vivax malaria.",
            "output": [
                "chloroquine"
            ]
        },
        {
            "id": "task1447-e75d0fb4725d468e9bbed5243b6fc2ae",
            "input": "Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.",
            "output": [
                "mitomycin C"
            ]
        },
        {
            "id": "task1447-08a90d8e2d0048bfa2f4092554f3b560",
            "input": "To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.",
            "output": [
                "mitomycin C"
            ]
        },
        {
            "id": "task1447-559d76a786b14282a2b348975928e321",
            "input": "A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.",
            "output": [
                "sulfonamide"
            ]
        },
        {
            "id": "task1447-5eac95ace4b2452daba44d293d8d7d8c",
            "input": "The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.",
            "output": [
                "sulfonamide"
            ]
        },
        {
            "id": "task1447-7fc1c939cc9b42a2b0f41b9cbb121ac4",
            "input": "Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-b51c334384604bffa6e379f001c6b9b3",
            "input": "Treatment of lithium-induced diabetes insipidus with amiloride.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-905b42adf342438daade68f8316ba94e",
            "input": "We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.",
            "output": [
                "granulocyte colony-stimulating factor"
            ]
        },
        {
            "id": "task1447-ed724463a56d4452a4795e51dd8d17ee",
            "input": "FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-9e459855483847e5a818a80c35cd19a6",
            "input": "Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-7cbb763e5f5b41e99ee4e726f27e4c3c",
            "input": "Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-02e4bc9506654d2f94e80d0640a24d9d",
            "input": "While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.",
            "output": [
                "prednisolone"
            ]
        },
        {
            "id": "task1447-d89adfd6b31e4762b0125a90bdef9320",
            "input": "Intrathecal methotrexate-induced acute cerebellar syndrome.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-8fc7e62a8e4e48f8b13322070f79e6e3",
            "input": "We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-639528e0d5264c7298f9bd7cf9579288",
            "input": "Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.",
            "output": [
                "doxycycline"
            ]
        },
        {
            "id": "task1447-37bbbc3380a245dfb85af688220727ae",
            "input": "Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-0f1447e87023419587e3537267e4a600",
            "input": "Isoniazid-induced anaphylaxis.",
            "output": [
                "Isoniazid"
            ]
        },
        {
            "id": "task1447-1699f95eb2a44079bbc500a8c432b5ec",
            "input": "Carbamazepine-related hyponatremia following cardiopulmonary bypass.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-828d55469ff1489b873c2a15b5217cc7",
            "input": "We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-75832452419445f4b82a23f9ef684974",
            "input": "After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.",
            "output": [
                "5-ASA"
            ]
        },
        {
            "id": "task1447-c7f44d081af64b2fb38ebeaf66aa9c5d",
            "input": "Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.",
            "output": [
                "5-aminosalicylic acid"
            ]
        },
        {
            "id": "task1447-d34b3b2960a54b39a591b2f8d1b3a682",
            "input": "This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.",
            "output": [
                "5-ASA"
            ]
        },
        {
            "id": "task1447-7803df32ecd9464c8d3250dce9e190a0",
            "input": "Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-b47a7344fa2947bc83f87f418051291c",
            "input": "Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.",
            "output": [
                "salazosulfapyridine"
            ]
        },
        {
            "id": "task1447-c307b477c24d4608b6f734c5dcbcc519",
            "input": "A lupus-like syndrome associated with infliximab therapy.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-de16fac4373e4d58a5942e438853e34b",
            "input": "Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.",
            "output": [
                "Infliximab"
            ]
        },
        {
            "id": "task1447-41e9c044bb4b466487021167b9712566",
            "input": "We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-d4e79a66490442d69366fda3ff2e7bca",
            "input": "Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.",
            "output": [
                "IFNalpha"
            ]
        },
        {
            "id": "task1447-111f9a0116dd425b9f25b3b74c687537",
            "input": "Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.",
            "output": [
                "Interferon-alpha"
            ]
        },
        {
            "id": "task1447-817c3a8d8a044d66be063c98c0e69182",
            "input": "The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.",
            "output": [
                "IFNalpha"
            ]
        },
        {
            "id": "task1447-9df6ec6425084c16bd710e76091f39e2",
            "input": "Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-8b9a57ec5cde4fb38bd17a607cc7d736",
            "input": "We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-580945a4b45543588db7bc8894851bed",
            "input": "Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.",
            "output": [
                "hepatitis B vaccination"
            ]
        },
        {
            "id": "task1447-27dae75bc82c435c8b8ff210a838103d",
            "input": "In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.",
            "output": [
                "hepatitis B vaccination"
            ]
        },
        {
            "id": "task1447-41e9aa9c595e4b2aa639e356b770ca0d",
            "input": "Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.",
            "output": [
                "diphenhydramine"
            ]
        },
        {
            "id": "task1447-055021272c454c00ae2d657abf11a394",
            "input": "Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.",
            "output": [
                "Diphenhydramine"
            ]
        },
        {
            "id": "task1447-bf4f307daa7a44df913ff223f85e1c61",
            "input": "However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.",
            "output": [
                "diphenhydramine"
            ]
        },
        {
            "id": "task1447-b7a04bbde7aa4dbfba1668bafe60d5ab",
            "input": "We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.",
            "output": [
                "diphenhydramine"
            ]
        },
        {
            "id": "task1447-fbcfb5403899481b881988c627da828e",
            "input": "We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-f74d148165264ed7afeaa3446de400d5",
            "input": "Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.",
            "output": [
                "prednisolone"
            ]
        },
        {
            "id": "task1447-fbb34a34c6cb4f6185738ef9375b0f6f",
            "input": "We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.",
            "output": [
                "prednisolone"
            ]
        },
        {
            "id": "task1447-32e0d32d4e8c4df6b6ee41eb0e2a76d0",
            "input": "However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.",
            "output": [
                "thalidomide"
            ]
        },
        {
            "id": "task1447-cdb10767be3b47868436fd2fcae3347d",
            "input": "After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-482eaac45d734590867720634f59b4b4",
            "input": "Multiple sclerosis-like disease secondary to alpha interferon.",
            "output": [
                "alpha interferon"
            ]
        },
        {
            "id": "task1447-d64287987f6e4edf9549b2073a8d2dae",
            "input": "PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-871b8803fca5459783431f960f8d9821",
            "input": "We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-091a7e7da95b45a8823702411a714a83",
            "input": "A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-24e4f8a2c1cc441198f67efacad06f4f",
            "input": "Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-405a8a5629964b369558516f7a54e248",
            "input": "Various case reports concerning dapsone-induced agranulocytosis are reviewed.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-5f2ae8046cb840ae9270a5120c8e52d2",
            "input": "Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-b6d648a6c71f400ea29785992097b74b",
            "input": "Acute psychosis associated with levetiracetam.",
            "output": [
                "levetiracetam"
            ]
        },
        {
            "id": "task1447-3cd11e2b6d2b4fb98399b13bacb3cf25",
            "input": "A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.",
            "output": [
                "levetiracetam"
            ]
        },
        {
            "id": "task1447-e225317541314b04bda4e603bc73f34a",
            "input": "The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.",
            "output": [
                "levetiracetam"
            ]
        },
        {
            "id": "task1447-2d826dccbe9b47119d550c506af15cfc",
            "input": "CASES: \"A\" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-ff1fb1a2c27c4323b959c82c55244f19",
            "input": "Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-c6c121f582e64bde8a1479629464b523",
            "input": "Risperidone-induced obsessive-compulsive symptoms in two children.",
            "output": [
                "Risperidone"
            ]
        },
        {
            "id": "task1447-9abb569b360b4d34b9184733899fdb12",
            "input": "Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.",
            "output": [
                "granulocyte macrophage-colony-stimulating factor"
            ]
        },
        {
            "id": "task1447-2a5cb87350b646358fa571f0192dbc33",
            "input": "Possible heart failure exacerbation associated with rosiglitazone: case report and literature review.",
            "output": [
                "rosiglitazone"
            ]
        },
        {
            "id": "task1447-f5e123117fcb42e0a19c4d7da6f1eea7",
            "input": "Enoxaparin-induced generalized exanthem.",
            "output": [
                "Enoxaparin"
            ]
        },
        {
            "id": "task1447-f933d81fe9614106b6bd44feae3e3776",
            "input": "Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-03247cf4c4804f1897c932a8c39a817a",
            "input": "To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-2c673867d8f84600984363ba33221544",
            "input": "This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.",
            "output": [
                "clonazepam"
            ]
        },
        {
            "id": "task1447-a9a37a1c9daa438183aa4daecad5dd61",
            "input": "Cefuroxime-induced immune hemolysis.",
            "output": [
                "Cefuroxime"
            ]
        },
        {
            "id": "task1447-22db286a07a14a8ebf28cfcc5e675694",
            "input": "We report the first case of IHA associated with cefuroxime administration.",
            "output": [
                "cefuroxime"
            ]
        },
        {
            "id": "task1447-044f02f09a174b75aeba96f68a6ba956",
            "input": "After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.",
            "output": [
                "argatroban"
            ]
        },
        {
            "id": "task1447-be252dba9529439994dc37fc4f863d74",
            "input": "Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-410eb4dea9ee4f6f897989acf656d8d6",
            "input": "Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.",
            "output": [
                "Argatroban"
            ]
        },
        {
            "id": "task1447-f40e5ab160fd4ab8a6826f04b1c1a842",
            "input": "Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-199167d9744f4678a84d2faa1ce4744f",
            "input": "The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-eaec89df4cff49d6a9995d247ffbee83",
            "input": "This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-15fb1e638ed4483bb1bf332fde30d6d8",
            "input": "This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-27d7c694f2b64f2da41aae404e73aad3",
            "input": "We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-cd8aca9aa66148a494266ad1d8917864",
            "input": "Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-4019d548247c499ab1165e6994f4db0f",
            "input": "Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.",
            "output": [
                "chymopapain"
            ]
        },
        {
            "id": "task1447-d8e2b72aca5248c9bf2478eae494b38a",
            "input": "Both patients suddenly became hypotensive after injection of chymopapain into a disk.",
            "output": [
                "chymopapain"
            ]
        },
        {
            "id": "task1447-e684f68e1d934c4ea5796e5b27bf52d5",
            "input": "The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-5b1a1cb15327438ba6ff94cf9e4a8be3",
            "input": "Carbamazepine-induced systemic lupus erythematosus-like disease.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-c8189a454e8f4a22a68345ec379d3b3f",
            "input": "The cases of CBZ-induced SLE reported in the literature were reviewed.",
            "output": [
                "CBZ"
            ]
        },
        {
            "id": "task1447-f788d22118af472ca3a3df8b9dd8e0ba",
            "input": "After four months, while receiving RH, he developed painful bilateral gynaecomastia.",
            "output": [
                "RH"
            ]
        },
        {
            "id": "task1447-deb717d06a6649f6b9d567cec0b1569b",
            "input": "Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-a24d12b4690d4a0ca089e48614ed1722",
            "input": "Isoniazid associated, painful, bilateral gynaecomastia.",
            "output": [
                "Isoniazid"
            ]
        },
        {
            "id": "task1447-928c1621402b4f5daf28f3bfe0a8d331",
            "input": "Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.",
            "output": [
                "Heparin"
            ]
        },
        {
            "id": "task1447-e46dbcc1b1d54e45909b858f38e0a563",
            "input": "Hemodynamic collapse following labetalol administration in preeclampsia.",
            "output": [
                "labetalol"
            ]
        },
        {
            "id": "task1447-f4ecf65cc62d4c9e8830940246756ff6",
            "input": "Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline.",
            "output": [
                "cabergoline"
            ]
        },
        {
            "id": "task1447-03c07038698a4bf0aba95287b2585e03",
            "input": "Flaccid quadriparesis was noted after discontinuation of vecuronium.",
            "output": [
                "vecuronium"
            ]
        },
        {
            "id": "task1447-edf9cea45e074b219b50135133ea684f",
            "input": "This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.",
            "output": [
                "vecuronium"
            ]
        },
        {
            "id": "task1447-506822be23734bf3bb2b76d9a4280a51",
            "input": "Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.",
            "output": [
                "isotretinoin"
            ]
        },
        {
            "id": "task1447-e45304d816104c289ebcea5fba08775a",
            "input": "Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-6f45f6fcb02e44dca80cd86b206b4b18",
            "input": "Our series of 3 patients supports a causal connection between bleomycin and scleroderma.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-2d2bb4750a3f41e191db2831e1c2c688",
            "input": "Scleroderma in association with the use of bleomycin: a report of 3 cases.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-31ddb9771d06426b93bd0a8480ca972d",
            "input": "We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-a1683f2dc2194bd79bdb62384d3584e7",
            "input": "A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.",
            "output": [
                "adrenaline"
            ]
        },
        {
            "id": "task1447-1f6ff2c9cbf14f8888e9620a694b4db5",
            "input": "Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.",
            "output": [
                "adrenaline"
            ]
        },
        {
            "id": "task1447-a16afdb7322845b8bda17b6ac7827abe",
            "input": "Carbamazepine-induced systemic lupus erythematosus.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-17314ff993e34d2b9ced71f85eb69383",
            "input": "SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-615cf294e22b4836af2739a90238a7ff",
            "input": "We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.",
            "output": [
                "13-cis-retinoic acid"
            ]
        },
        {
            "id": "task1447-9e3d818f9e264fa49e3c8625fb76464d",
            "input": "Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-7e7b146fb9b344afb918ec978d691299",
            "input": "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.",
            "output": [
                "Valproic acid"
            ]
        },
        {
            "id": "task1447-bd7c8d83b9224d9fa2d928d09be165e1",
            "input": "Asterixis induced by carbamazepine therapy.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-3b30df0051d64fcea4497295c1ba28ea",
            "input": "Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-ec46629fc14544f598527514a89cd68f",
            "input": "This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.",
            "output": [
                "Tegretol"
            ]
        },
        {
            "id": "task1447-39ea9f5b7bb34560a94372c773701998",
            "input": "Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.",
            "output": [
                "norethisterone"
            ]
        },
        {
            "id": "task1447-b7274f57f5a64ffdba7600f4130cca09",
            "input": "In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).",
            "output": [
                "norethisterone"
            ]
        },
        {
            "id": "task1447-44278aba62404fd890f208fa587e9a72",
            "input": "Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.",
            "output": [
                "Norethisterone"
            ]
        },
        {
            "id": "task1447-6853da65a15f4bff9b583e16b24319fd",
            "input": "An adverse reaction to IFN was strongly suspected as the cause of CHF.",
            "output": [
                "IFN"
            ]
        },
        {
            "id": "task1447-1ab500f04758429ca3e0dcfe8a529348",
            "input": "Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.",
            "output": [
                "recombinant alpha-interferon"
            ]
        },
        {
            "id": "task1447-be510dacb6a04f38b262a90e92dadec4",
            "input": "Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-e997c645b1ab42efbea75661b16597fc",
            "input": "We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-348277efccbd4729bca6a32310340bd8",
            "input": "Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.",
            "output": [
                "ganciclovir"
            ]
        },
        {
            "id": "task1447-7fc096567482453c8d9316dca5192ef4",
            "input": "Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-2deed99a739c41c6826b448ddba95c3d",
            "input": "Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-3e9007ebeb4744ecad4939e114ad1990",
            "input": "The mechanism of RTA induced by FK506 has not yet been clearly elucidated.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-f03b2e307dc645988818bcb4f2b7caf3",
            "input": "The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-ced2c685ab33481a965e8c2f70496c4a",
            "input": "We report a case of RTA secondary to FK506 administration in liver transplantation.",
            "output": [
                "FK506"
            ]
        },
        {
            "id": "task1447-4fa031c27a0e497db40d3a583ba4227f",
            "input": "A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.",
            "output": [
                "L-dopa"
            ]
        },
        {
            "id": "task1447-0fe1c1bc544447319818064b12f39d53",
            "input": "L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.",
            "output": [
                "L-DOPA"
            ]
        },
        {
            "id": "task1447-a6d73aafdbc3433fbd2ef578a0e082e9",
            "input": "The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.",
            "output": [
                "L-dopa"
            ]
        },
        {
            "id": "task1447-fdf17de28834455498d3468ab364fb73",
            "input": "Neurotoxicity of intrathecal methotrexate: MR imaging findings.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-525b1197f5e74700b40684e86b0f74d3",
            "input": "We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-101a8848832b4ee19f99fb58949ce8b0",
            "input": "We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.",
            "output": [
                "glyburide"
            ]
        },
        {
            "id": "task1447-47c0bfc6ece64fffbcff58e8eb1c12d0",
            "input": "Ocular ethambutol toxicity.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-47fb64e609be4487a4bee99a83a164ae",
            "input": "The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-345526a2ca26407f8c091bc5fa3b30fc",
            "input": "We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-8d03ad28d99b4f28a45b91ed1810c1cb",
            "input": "Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.",
            "output": [
                "acenocoumarol"
            ]
        },
        {
            "id": "task1447-c8d64c6d20d74f6dab156763c1094cb3",
            "input": "We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode.",
            "output": [
                "acenocoumarol"
            ]
        },
        {
            "id": "task1447-28b78fbf28af4092b7d43a4101f3e7dc",
            "input": "Colchicine-induced myopathy in a teenager with familial Mediterranean fever.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-c6cdfc88b18641ee847b0a6e7ea4311b",
            "input": "CONCLUSIONS: Colchicine-induced myopathy should be excluded in patients with FMF who present with generalized muscle weakness.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-7dc8701e26a44eb888bef28462f6c6e6",
            "input": "DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-0ca4d893aa4f405fba51347894ca21df",
            "input": "In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-fb7a21ff5bce483991784721424021a1",
            "input": "OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-6d4fe5fd62d24e0c9b331e3bebfbe600",
            "input": "Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.",
            "output": [
                "dexamethasone"
            ]
        },
        {
            "id": "task1447-ab076edb96c44dfb850c2fd11c791374",
            "input": "A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-337ccc28c8904426ab5547171c9bcea7",
            "input": "Infliximab-induced lupus in Crohn's disease: a case report.",
            "output": [
                "Infliximab"
            ]
        },
        {
            "id": "task1447-ebbcff1069274edaa2fad3a4ab808035",
            "input": "This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-df926e0ce8944e97942ee03b556770c2",
            "input": "Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.",
            "output": [
                "yohimbine"
            ]
        },
        {
            "id": "task1447-9eb9438e2c8c41eba57acc595e90690d",
            "input": "We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.",
            "output": [
                "yohimbine"
            ]
        },
        {
            "id": "task1447-53f70539f2224967a5d327ad7e69cd6f",
            "input": "After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.",
            "output": [
                "vitamin D3"
            ]
        },
        {
            "id": "task1447-6a2d933c3b534e4e84e75b993f69e3cf",
            "input": "2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.",
            "output": [
                "2-Chloro-deoxyadenosine"
            ]
        },
        {
            "id": "task1447-b74f03547f5c4a78a42498aea33f8451",
            "input": "Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.",
            "output": [
                "2-CdA"
            ]
        },
        {
            "id": "task1447-2c6a0b0221c6474ba8b7b9aa73aca0f2",
            "input": "All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-0ba8602fa37e4b31913c9dc091af4e96",
            "input": "Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-ec7effb8af2d4558b96913191dc751ef",
            "input": "Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-8fb417555af4484f819110626b547abe",
            "input": "We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-3a75f4f37064422d978b5d308f15b375",
            "input": "METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.",
            "output": [
                "topiramate"
            ]
        },
        {
            "id": "task1447-a761473842f74ed4ad7bca20955f2938",
            "input": "Doxycycline-induced photo-onycholysis.",
            "output": [
                "Doxycycline"
            ]
        },
        {
            "id": "task1447-b58d5e7fa428469bbb352166afbd0c2e",
            "input": "We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.",
            "output": [
                "doxycycline"
            ]
        },
        {
            "id": "task1447-e41c43817d994076a9868cda14c160cc",
            "input": "A new type of minocycline-induced cutaneous hyperpigmentation.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-f30bc54a1e96400eafe020f4dd66cbe8",
            "input": "Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-857a9a06caae401db4a3a36cb1a84d00",
            "input": "This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-0a5ab4a1de44449abf3c70eb105f341d",
            "input": "Three distinct types of minocycline-induced cutaneous pigmentation have been described.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-f0c19c03427346ed8051e9d438d65397",
            "input": "We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.",
            "output": [
                "minocycline"
            ]
        },
        {
            "id": "task1447-06852b6effb94cd29ff837646d8b89f2",
            "input": "Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-510fffbda285448896aad4e46413c607",
            "input": "We report here a case of TEN after administration of ciprofloxacin.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-979e87fba6d04545adf32aec56988b35",
            "input": "A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.",
            "output": [
                "amifostine"
            ]
        },
        {
            "id": "task1447-6dadd24e44394a4a9af69d62a06443a4",
            "input": "Amifostine-induced fever: case report and review of the literature.",
            "output": [
                "Amifostine"
            ]
        },
        {
            "id": "task1447-f5c38bdcbac14d3d80b1febd06e87666",
            "input": "To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.",
            "output": [
                "amifostine"
            ]
        },
        {
            "id": "task1447-0d6f0a2785ab4ef5884ef6fccfb09287",
            "input": "Acute interstitial nephritis due to pantoprazole.",
            "output": [
                "pantoprazole"
            ]
        },
        {
            "id": "task1447-9c9a0f27a03546dd9b838bdeb822c53d",
            "input": "After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.",
            "output": [
                "pantoprazole"
            ]
        },
        {
            "id": "task1447-ca1179df3f2f4157a9b6bf41d8e937b7",
            "input": "OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.",
            "output": [
                "pantoprazole"
            ]
        },
        {
            "id": "task1447-f23b8f9daeb045139b88baf101b18c70",
            "input": "The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.",
            "output": [
                "pantoprazole"
            ]
        },
        {
            "id": "task1447-0de93282bd194a0f82307c46f7ce7b1e",
            "input": "There have been several reported cases of omeprazole-induced AIN.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-1e09d2e3816b4360a3d24d97b8b54164",
            "input": "Propecia-associated bilateral cataract.",
            "output": [
                "Propecia"
            ]
        },
        {
            "id": "task1447-0fd3b4d5d93c465e810d496cc6a09f44",
            "input": "To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.",
            "output": [
                "Propecia"
            ]
        },
        {
            "id": "task1447-0371525c130e4e34a3b4aaeb8c652ad5",
            "input": "Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.",
            "output": [
                "interferon beta-1a"
            ]
        },
        {
            "id": "task1447-ad6eba9afa8349a0924c39eef5b3b8a7",
            "input": "CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.",
            "output": [
                "methylphenidate"
            ]
        },
        {
            "id": "task1447-9f0575c2d8b141668d125193e3699472",
            "input": "CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.",
            "output": [
                "methylphenidate"
            ]
        },
        {
            "id": "task1447-09ea1656c69f4e3aac9da9a3afa28126",
            "input": "Fixed drug eruption of the scrotum due to methylphenidate.",
            "output": [
                "methylphenidate"
            ]
        },
        {
            "id": "task1447-13be3615b7c744c686dea4c98b8289ce",
            "input": "OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.",
            "output": [
                "methylphenidate"
            ]
        },
        {
            "id": "task1447-5a9182eb941148df830cc7db103b524b",
            "input": "Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-3de5134d99754a24b934982edd917254",
            "input": "We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-951095dedaea4dffab34ebac67dba553",
            "input": "BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-3a5ff6b3425742c585deff3bd8702347",
            "input": "CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-bafee487176c4094a79fbad66f70ca8e",
            "input": "Warfarin-associated thoracic aortic dissection in an elderly woman.",
            "output": [
                "Warfarin"
            ]
        },
        {
            "id": "task1447-fad3c82438204287878942af914b2f7f",
            "input": "Cutaneous vasculitis secondary to ramipril.",
            "output": [
                "ramipril"
            ]
        },
        {
            "id": "task1447-424d9a156b5742289e8c18078f2e678d",
            "input": "Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.",
            "output": [
                "ramipril"
            ]
        },
        {
            "id": "task1447-029a42d1a9594aa5b01c4d77792b7e2f",
            "input": "Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.",
            "output": [
                "Ramipril"
            ]
        },
        {
            "id": "task1447-42d56a610f044f8a9084ae2873612992",
            "input": "CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-f0e3b25b460949bbaefd99ec88f2eae4",
            "input": "Neurological improvement and rehabilitation potential following toxic myelopathy due to intrathecal injection of doxorubicin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-b7fccce990544bdfa075ec89ab11cb77",
            "input": "RESULTS: Evidence of neurological improvement and rehabilitation potential after severe myelopathy due to intrathecal injection of doxorubicin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-46a493ce68a047478f37862a60d3d32a",
            "input": "STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-43dedb66d3a14b60ab68b63dd5f92a0e",
            "input": "Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-c30729994af647a59d4423bc8016941b",
            "input": "We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.",
            "output": [
                "Kayexalate"
            ]
        },
        {
            "id": "task1447-301bdefb4f9e4189828cf9ba983ca406",
            "input": "Bull's-eye maculopathy associated with quinacrine therapy for malaria.",
            "output": [
                "quinacrine"
            ]
        },
        {
            "id": "task1447-273a1b4602c34c5cb6226a7c771b92b0",
            "input": "RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria.",
            "output": [
                "quinacrine"
            ]
        },
        {
            "id": "task1447-45f823ec26c2408f96ffb4df9ebe7eda",
            "input": "Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.",
            "output": [
                "phenylpropanolamine"
            ]
        },
        {
            "id": "task1447-6b5686f2bfab470e8ea5d3f469487b83",
            "input": "We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.",
            "output": [
                "PPA"
            ]
        },
        {
            "id": "task1447-31ca67bf22014bc5861203f81411ac6a",
            "input": "Ciprofloxacin-induced psychosis.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-8d035fd904944bb48b260a4859f9986a",
            "input": "DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-1608e26fdbf249869faac1a31a75a45b",
            "input": "OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-c911a336f81e4a129b6a82bd148c0aba",
            "input": "Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-b5479271c87a4a8bb2e601506500bf29",
            "input": "Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-dbc65d43b7b5498f8b9e2be3e8f38dc2",
            "input": "We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-6e991e5dab9640f7ac98eef5dd6bb41e",
            "input": "It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.",
            "output": [
                "dexamethasone"
            ]
        },
        {
            "id": "task1447-d2e55137d5174bfd90557fd0cb77ff58",
            "input": "Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.",
            "output": [
                "dexamethasone"
            ]
        },
        {
            "id": "task1447-70b24bb01e03432d9a4f82b289ce56d8",
            "input": "Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.",
            "output": [
                "dexamethasone"
            ]
        },
        {
            "id": "task1447-c88309aa35e249e18a4a7797140aa659",
            "input": "Development of Peyronie's disease during long-term colchicine treatment.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-4aa9d7a3ea234a7a80a52e9d6a41d619",
            "input": "However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-05ef89273ec44742a71e5286ce813473",
            "input": "A patient developed cholestatic hepatitis while being treated with nitrofurantoin.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-e130aff53dae4653a36b782e55761d97",
            "input": "A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.",
            "output": [
                "phenobarbital"
            ]
        },
        {
            "id": "task1447-41a125e8723b4990a5463cf88a1a34ad",
            "input": "Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.",
            "output": [
                "phenobarbital"
            ]
        },
        {
            "id": "task1447-f01c0a743483421fa9b1fdfd13fe811b",
            "input": "Pilocarpine toxicity and the treatment of xerostomia.",
            "output": [
                "Pilocarpine"
            ]
        },
        {
            "id": "task1447-6a7141c1ac1c4dd5bbaeb4fbf2a97283",
            "input": "Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.",
            "output": [
                "Bellamine S"
            ]
        },
        {
            "id": "task1447-90d6669203ff4ced9be2f70d1c89b419",
            "input": "A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-3736d98079134edc8235a4fade23191b",
            "input": "Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-6ef423f94f4f4e4b819e12c3316ba3df",
            "input": "Gemcitabine-related radiation recall preferentially involves internal tissue and organs.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-c73043a9b9a941809828148fa75b2ade",
            "input": "The literature search found 12 cases of radiation recall caused by gemcitabine.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-775fd7d24b164f0e83159b38514ef204",
            "input": "The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-5640ef119abb47e48595b7de7b8657c1",
            "input": "An immediate hemolytic reaction induced by repeated administration of oxaliplatin.",
            "output": [
                "oxaliplatin"
            ]
        },
        {
            "id": "task1447-44cfa212e8574db4b11924db4ae9a2e5",
            "input": "CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.",
            "output": [
                "oxaliplatin"
            ]
        },
        {
            "id": "task1447-d1c7c0572cc5449eacca55d349da2e9d",
            "input": "Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-936692cd3dbe47f1af44d8c10dd69f34",
            "input": "Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-73dda0e149114bb6aa504d9d8c33ae0c",
            "input": "We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-d9602f15feaf4af1a05972af65a48319",
            "input": "One patient developed large intramural esophageal hematoma as a complication of heparin therapy.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-84f9478a5f0f4859bd79bbd583be60a0",
            "input": "Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.",
            "output": [
                "dimethyl sulfoxide"
            ]
        },
        {
            "id": "task1447-e8952be62efd432d97b2e71cde043e70",
            "input": "Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.",
            "output": [
                "pegylated interferon alpha"
            ]
        },
        {
            "id": "task1447-c2c26075ce6e498491a9ce6110a97958",
            "input": "In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.",
            "output": [
                "pegylated interferon alpha"
            ]
        },
        {
            "id": "task1447-f3fc10e223ab46d3b6f9fdbaad68d184",
            "input": "Restless legs syndrome due to interferon-alpha.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-c57b8064fbeb460383bd4b2f3d733045",
            "input": "Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.",
            "output": [
                "IFN alpha"
            ]
        },
        {
            "id": "task1447-1ca100e86ab64ea4a58bad7ddf0c152b",
            "input": "We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.",
            "output": [
                "naltrexone"
            ]
        },
        {
            "id": "task1447-128a16b419c9404cbc84bbece33e7681",
            "input": "Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.",
            "output": [
                "sargramostim"
            ]
        },
        {
            "id": "task1447-45358eacf5324044b46403dd4839e346",
            "input": "We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.",
            "output": [
                "sargramostim"
            ]
        },
        {
            "id": "task1447-59cc638e48184011af5b7e4e48a5cbe3",
            "input": "The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-7c74718696e94db0b6aa2dda53055473",
            "input": "The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-24e1c38ad9bd46e294ce84e46da1a2d8",
            "input": "Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.",
            "output": [
                "levodopa"
            ]
        },
        {
            "id": "task1447-054ad8e717e64a3aa00cba2d9818d413",
            "input": "A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.",
            "output": [
                "prostaglandin"
            ]
        },
        {
            "id": "task1447-1026d63da384443fb517837bc32d42ac",
            "input": "Trichiasis associated with prostaglandin analog use.",
            "output": [
                "prostaglandin"
            ]
        },
        {
            "id": "task1447-52a33ac97d614102927613c1d2ffdfd4",
            "input": "Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-184eba9920af4875bfbffba952d08aa8",
            "input": "These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-7f0df605d9674a5f80129fd4647bc980",
            "input": "We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-b04d179d56dd4021b59611b5b00b6bcf",
            "input": "We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-f8d312b9c8bf44dbb1e3af3d33203b49",
            "input": "Dorzolamide-induced choroidal detachment in a surgically untreated eye.",
            "output": [
                "Dorzolamide"
            ]
        },
        {
            "id": "task1447-73d6de8022ca426a9336c7b516dc82f9",
            "input": "METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.",
            "output": [
                "dorzolamide"
            ]
        },
        {
            "id": "task1447-389eb350c01343fdbe967b2b9d6ce7d9",
            "input": "We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.",
            "output": [
                "dorzolamide"
            ]
        },
        {
            "id": "task1447-1bdca622184b414ca4d34bef090d852e",
            "input": "Deepening of lid sulcus from topical bimatoprost therapy.",
            "output": [
                "bimatoprost"
            ]
        },
        {
            "id": "task1447-703f1141c4fe4006a13814a4e2a97383",
            "input": "Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.",
            "output": [
                "hepatitis B vaccination"
            ]
        },
        {
            "id": "task1447-eb1977c86282479f8f63c5c508b3a254",
            "input": "Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.",
            "output": [
                "sulfadoxine-pyrimethamine"
            ]
        },
        {
            "id": "task1447-4c99967dfafd4cf4bf92945ea1a232af",
            "input": "Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-b81d35be6de547e8b3b7fcb40c68d9bc",
            "input": "Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-a49a1ba1db6a42848d61e20131b81cad",
            "input": "After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.",
            "output": [
                "indapamide"
            ]
        },
        {
            "id": "task1447-3d300f603c6448ebb8f76b1f8b51d9d6",
            "input": "After stopping indapamide, glucose tolerance impairing may be reversed.",
            "output": [
                "indapamide"
            ]
        },
        {
            "id": "task1447-0273a7c33bda422e941a429f76442537",
            "input": "CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.",
            "output": [
                "indapamide"
            ]
        },
        {
            "id": "task1447-39e8290ddb3c41a5913bba1ddf4088c9",
            "input": "Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).",
            "output": [
                "indapamide"
            ]
        },
        {
            "id": "task1447-21fa30604f534a71b1e56f8f06117e8b",
            "input": "CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).",
            "output": [
                "imatinib mesylate"
            ]
        },
        {
            "id": "task1447-341bf2c3a6b54f1a84f51edb952843d0",
            "input": "Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-ae78df3773b7468e9101b2b3c6e62954",
            "input": "In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-112e2315e28e4a49bd6f16dde5517277",
            "input": "OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-799df8a89ea5407ea35995cfe8ba5f02",
            "input": "Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-f66ef1ca87fc49799d8b3399742f61b4",
            "input": "Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.",
            "output": [
                "imatinib mesylate"
            ]
        },
        {
            "id": "task1447-dde0b63a20bb4cb3b0dad3f73fdbb432",
            "input": "L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-4a0c85b3126c412788669ab5ebcf6e2c",
            "input": "Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-ac0036c7bf64410f81d54600651e1617",
            "input": "Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-39ed2432ad5c43209f8c900170412047",
            "input": "We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-231b435bab834b57962db1580d5db1cc",
            "input": "Disulfiram-induced fulminant hepatic failure in an active duty soldier.",
            "output": [
                "Disulfiram"
            ]
        },
        {
            "id": "task1447-0d492b92d3c54314ad2b5bcd8f11822c",
            "input": "Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-5c2f0fb5f4e94509b6b01b8483d0be9e",
            "input": "This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-0d82c1a510af451aae3ed55cb1e13b97",
            "input": "Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.",
            "output": [
                "Tiagabine"
            ]
        },
        {
            "id": "task1447-c78420032fa94d00b5533ac7d76cf64d",
            "input": "A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.",
            "output": [
                "linezolid"
            ]
        },
        {
            "id": "task1447-7faab5d782a44f1e89151356779a62b3",
            "input": "As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.",
            "output": [
                "linezolid"
            ]
        },
        {
            "id": "task1447-473d5895ddbd499eac3006411274f136",
            "input": "Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.",
            "output": [
                "linezolid"
            ]
        },
        {
            "id": "task1447-9fee03b8a1f14cc2a1099e273f426dfb",
            "input": "In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.",
            "output": [
                "prostaglandin E1"
            ]
        },
        {
            "id": "task1447-a356c4a944fc44c1bf9f44410ece259d",
            "input": "The harlequin color change and association with prostaglandin E1.",
            "output": [
                "prostaglandin E1"
            ]
        },
        {
            "id": "task1447-8a6915254e1f4ad0abb581c25bb0e5e7",
            "input": "Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-a6428cbe859449449434a0b76f656eff",
            "input": "Ciprofloxacin-induced renal insufficiency in cystic fibrosis.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-ea987d9bf9e0449db2d81296608998b7",
            "input": "Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-9c247c48a08749128ac19858cbd21f7e",
            "input": "We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-10e7b6a0d7c241d7a74929ffac4862d5",
            "input": "An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-f76004c5634f4972bad4d7dfbb4bbd05",
            "input": "Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-b2ff8100b15848c79c35bfd581ecf581",
            "input": "Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-9cd182ba32d84b89a7b5a8b856b1100f",
            "input": "In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-09387a6721704f76aafa570672d7e771",
            "input": "Unusual hypersensitivity to warfarin in a critically ill patient.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-6f2bf016fade4999a79a74f4a79bc83e",
            "input": "During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.",
            "output": [
                "CAP"
            ]
        },
        {
            "id": "task1447-1a46111457f548538c18e18a843eabb2",
            "input": "Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.",
            "output": [
                "CAP"
            ]
        },
        {
            "id": "task1447-a0ca05a08290456cadff61a0b8f4c478",
            "input": "Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).",
            "output": [
                "CAP"
            ]
        },
        {
            "id": "task1447-ba3513f61e0249e8bff284db01957dad",
            "input": "Peripheral neuropathy associated with capecitabine.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-c6b325068956462aa71ec83fd5aa0ad0",
            "input": "We conclude peripheral neuropathy with 5-FU is rare.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-f34de7b358d549338c8cd2aaf94ad2fd",
            "input": "Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.",
            "output": [
                "rosiglitazone"
            ]
        },
        {
            "id": "task1447-ae5ba4b390cb42a7bf8ede17703eab2b",
            "input": "We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.",
            "output": [
                "rosiglitazone"
            ]
        },
        {
            "id": "task1447-fd09a6350ca4424f8629eafc9d36685f",
            "input": "In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-92cec02abdeb4a14a38a9e757182ecf0",
            "input": "These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-ba907da78cf241fda9c30432132d25c8",
            "input": "We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-827621cbb03f4dc497826b8dfcc81ffd",
            "input": "After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.",
            "output": [
                "sertraline"
            ]
        },
        {
            "id": "task1447-e83b3489ee07415f8f4380241dfed771",
            "input": "Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-9edd6d1361414ab7a6ed4dd48a204750",
            "input": "This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-5fe68a22df7d4799be81ae6ef156469a",
            "input": "Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.",
            "output": [
                "flupirtine"
            ]
        },
        {
            "id": "task1447-e6053ee84abd446b8f4b069d1083badc",
            "input": "We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.",
            "output": [
                "flupirtine"
            ]
        },
        {
            "id": "task1447-79a7b5b42ffd489093ed43f17d2a9313",
            "input": "We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.",
            "output": [
                "metaraminol"
            ]
        },
        {
            "id": "task1447-8e2d350032af40f1a6cff51b1cccca7d",
            "input": "In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-e0b024e297404eb981c670e200c0f27d",
            "input": "Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-615b058e14814f0889ceec9076d3e6e5",
            "input": "After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.",
            "output": [
                "PTU"
            ]
        },
        {
            "id": "task1447-f2d2b2b244a0487e901f0d5b7b2b2693",
            "input": "Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-8463ae63900a47b8b1e3737af67ff0b8",
            "input": "We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.",
            "output": [
                "PTU"
            ]
        },
        {
            "id": "task1447-4fde61e4811845d79ab5b3ff1d3d7cc0",
            "input": "OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-5b7cc20d40be4ff6bc7bf02263a2edcc",
            "input": "Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-9ea2a573d613494ea68c96e854f535e5",
            "input": "Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-adb7906b3e554c379b03a381dea7ca3f",
            "input": "The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-0b0c4c4b049e4079a50c23d287f7d37b",
            "input": "Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-d4041991dc144d77979d69e7a9d3c52a",
            "input": "DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.",
            "output": [
                "AZA"
            ]
        },
        {
            "id": "task1447-ced32135066e45b7abc19dae9076a65c",
            "input": "Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-79e99f6228f0445788c5a10c1be206c5",
            "input": "We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.",
            "output": [
                "AZA"
            ]
        },
        {
            "id": "task1447-2358d846aa144cb9878a41bab9866f1f",
            "input": "Tardive dyskinesia in 2 patients treated with ziprasidone.",
            "output": [
                "ziprasidone"
            ]
        },
        {
            "id": "task1447-502baceb76b849dda649c664103c9e9e",
            "input": "Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.",
            "output": [
                "ziprasidone"
            ]
        },
        {
            "id": "task1447-a9fc20022ded4a2dbb5754d89a9bd8cd",
            "input": "Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-c5578bc4ef1a4a989448f3ac2f302b60",
            "input": "The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-3194bfb0108940a1ba0b356361cbaa1b",
            "input": "Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.",
            "output": [
                "retinoic acid"
            ]
        },
        {
            "id": "task1447-c7ef5ff805774e7c91b8d4598e3ff803",
            "input": "The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.",
            "output": [
                "ATRA"
            ]
        },
        {
            "id": "task1447-26557b6f5b5949f2a0a7559371ed3d05",
            "input": "We report the development of scrotal ulcer in a patient with acute promyleocytic leukemia (APL) within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily.",
            "output": [
                "ATRA"
            ]
        },
        {
            "id": "task1447-c685f07c924e4924afb7b93232177fa9",
            "input": "A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-c27cc1bced2647e6a1bc2b58e2146788",
            "input": "Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-2a8839b4f9104174b27a08c1b572ef69",
            "input": "These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-e37eeab3b17a4903ac8a25980e7214a9",
            "input": "We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-0edd35ada72f4615aa438e154c1c28f3",
            "input": "CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.",
            "output": [
                "rofecoxib"
            ]
        },
        {
            "id": "task1447-ba4cb2cca6b44c168fb35c771fe7f5a4",
            "input": "OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.",
            "output": [
                "rofecoxib"
            ]
        },
        {
            "id": "task1447-67608f32518046c49faf9502f1cb4c66",
            "input": "To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-c62a419a43854af184b0c0e832828840",
            "input": "We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-b635aa3b3b954f7086b8e3709fd809d1",
            "input": "Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.",
            "output": [
                "thalidomide"
            ]
        },
        {
            "id": "task1447-0d66c80560774477be68772949c688f1",
            "input": "Thalidomide neuropathy in childhood.",
            "output": [
                "Thalidomide"
            ]
        },
        {
            "id": "task1447-7bb50e229c024d52ac4a191999c59673",
            "input": "Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.",
            "output": [
                "Thalidomide"
            ]
        },
        {
            "id": "task1447-01014e96e42242daa7ee3a06e9d60c79",
            "input": "We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.",
            "output": [
                "thalidomide"
            ]
        },
        {
            "id": "task1447-e2d796b2d30645709307b0be75fe89b5",
            "input": "Cerebral edema associated with Gliadel wafers: two case studies.",
            "output": [
                "Gliadel"
            ]
        },
        {
            "id": "task1447-1dfe13e19a28469080a99b79952f1248",
            "input": "Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers.",
            "output": [
                "Gliadel"
            ]
        },
        {
            "id": "task1447-a688d83a16cc444e91c847ffaaadc97a",
            "input": "It is likely that RA contributed to the deterioration in renal function in these patients.",
            "output": [
                "RA"
            ]
        },
        {
            "id": "task1447-d965b97a90334c87911d5ebdd5c05295",
            "input": "Retinoic acid may increase the risk of bone marrow transplant nephropathy.",
            "output": [
                "Retinoic acid"
            ]
        },
        {
            "id": "task1447-70dbf42e5dc64f29b39a3dbad8753812",
            "input": "The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.",
            "output": [
                "RA"
            ]
        },
        {
            "id": "task1447-0b3aed17c694440bb323683829e95971",
            "input": "He developed a late secondary infection in some sites treated with imiquimod.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-689464eda73a4b8996234164f5444121",
            "input": "A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-d012dddb700b41caa06af6b91c8cf90d",
            "input": "Quetiapine-induced myoclonus.",
            "output": [
                "Quetiapine"
            ]
        },
        {
            "id": "task1447-66b72e7426ef4ceca583f310a20a370d",
            "input": "We report a case of myoclonus induced by quetiapine.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-3c2314d548ca4b478dbfcfc1e547093c",
            "input": "Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-ee1ddbe89c8744a489c06396663aeb34",
            "input": "Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.",
            "output": [
                "penicillin"
            ]
        },
        {
            "id": "task1447-ac99c867b877481a884ad5bda13a7b21",
            "input": "Livedo reticularis associated with interferon alpha therapy in two melanoma patients.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-c28fc61167cc4257921a1aa1e0e5c7fb",
            "input": "These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-c5bb9b2f01b5452685b0f878b040c938",
            "input": "We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.",
            "output": [
                "interferon alpha 2b"
            ]
        },
        {
            "id": "task1447-f22586d959304f7d94ee16b8c55e5c66",
            "input": "Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-e3537bcbca704573907fab3a4c7c45b5",
            "input": "During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-97a54070e39f41e4bec41b3f7ff4213d",
            "input": "In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-de802849f78f4f57a89c10bbded1fcea",
            "input": "It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.",
            "output": [
                "flucloxacillin"
            ]
        },
        {
            "id": "task1447-96fc2a85810947d898216c18b57e2623",
            "input": "Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.",
            "output": [
                "Zoledronic acid"
            ]
        },
        {
            "id": "task1447-00af895a88b34f688426480add24a304",
            "input": "Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-81af8d3db07b4329a95b989fb8b7bedf",
            "input": "We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-513a9559be924719b3123eb4a06e63d9",
            "input": "Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.",
            "output": [
                "Risperidone"
            ]
        },
        {
            "id": "task1447-39893a893a49486aa7bd4cfde79100e5",
            "input": "Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.",
            "output": [
                "SDA"
            ]
        },
        {
            "id": "task1447-63b358a220574001bc3ba64443091032",
            "input": "To date, there have been few reports of visual disturbances associated with BTX-B use.",
            "output": [
                "BTX-B"
            ]
        },
        {
            "id": "task1447-03316ae1acf64ca58dc0f7d22066fa8f",
            "input": "Enalapril-induced anemia in two kidney transplant recipients.",
            "output": [
                "Enalapril"
            ]
        },
        {
            "id": "task1447-6904f1c548c94e03a37107e6544ac357",
            "input": "Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.",
            "output": [
                "enalapril"
            ]
        },
        {
            "id": "task1447-ddeef221cfed456b9ad4e626000ad116",
            "input": "Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.",
            "output": [
                "cerivastatin"
            ]
        },
        {
            "id": "task1447-43fa5e4ea30345bebeeacdb64a264523",
            "input": "We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.",
            "output": [
                "cerivastatin"
            ]
        },
        {
            "id": "task1447-1a3ecd1a9e4c47b9abff320deeac6c4a",
            "input": "TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.",
            "output": [
                "cyclosporine"
            ]
        },
        {
            "id": "task1447-a5f7efe5e73d4af4a687115fdfa7506c",
            "input": "Chronic fentanyl application induces adrenocortical insufficiency.",
            "output": [
                "fentanyl"
            ]
        },
        {
            "id": "task1447-2f6c15de10b64170a12d0134940c74ea",
            "input": "We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.",
            "output": [
                "fentanyl"
            ]
        },
        {
            "id": "task1447-99b0334e0c00412e86f3aba00965bb6c",
            "input": "Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.",
            "output": [
                "Fluphenazine"
            ]
        },
        {
            "id": "task1447-b37a262bdee142f89cb6f5582a4bbd67",
            "input": "Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-80b1533423e048639b10b868743deb1e",
            "input": "We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-3e36ed7e68d04d0ea4faf06ff63098d2",
            "input": "CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-a62b836aef4a4cac8b7656507ddaff61",
            "input": "Corneal endothelial deposits associated with rifabutin use.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-21405f035a2340f691d252bf4188b0bf",
            "input": "PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-495e162df6144adeae73df9986847424",
            "input": "RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-4a73a05895f14dd7ba9e25b9dc0b69c4",
            "input": "CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-5ef3989769324304aab85e49fa406e4e",
            "input": "CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-4d1b88cd0e6d45c8aa632010dbf245ef",
            "input": "Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-9f5db2e0b98d43d9aa629e92200a7263",
            "input": "We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-fcd6c2c72f94409388539ad0494546af",
            "input": "Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.",
            "output": [
                "MMF"
            ]
        },
        {
            "id": "task1447-61204863fec843faa46ba60e313fc54d",
            "input": "Mycophenolate mofetil-induced neutropenia in liver transplantation.",
            "output": [
                "Mycophenolate mofetil"
            ]
        },
        {
            "id": "task1447-f6a96544d84d433ca5b62b40deb45f95",
            "input": "The mean time from starting MMF to the development of neutropenia was 4 months.",
            "output": [
                "MMF"
            ]
        },
        {
            "id": "task1447-916fc14b8d2f49f0ae8eb26de461b1a2",
            "input": "The side effects of MMF, such as bone marrow toxicity, have been reported.",
            "output": [
                "MMF"
            ]
        },
        {
            "id": "task1447-fbffa4187fd148529251eff3c89dec61",
            "input": "The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.",
            "output": [
                "anti-D IGIV"
            ]
        },
        {
            "id": "task1447-c7d4946ff9974ec39338304315288285",
            "input": "After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-87aabb0b8cd04d889476ce6d808f7922",
            "input": "Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-28e3894ea03e4c369882fbab6f60aa8b",
            "input": "High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-da1f0b989c584419839c3e1d6adcd330",
            "input": "After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.",
            "output": [
                "pentamidine"
            ]
        },
        {
            "id": "task1447-ac89bab0be8e4f6bbacaaa4a9bda131c",
            "input": "Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.",
            "output": [
                "pentamidine"
            ]
        },
        {
            "id": "task1447-43a0d5f852ab42c38a560de2aa209956",
            "input": "Falling backward in two elderly patients taking bupropion.",
            "output": [
                "bupropion"
            ]
        },
        {
            "id": "task1447-7ac04e9951cf4857bbfa9e0642135272",
            "input": "RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.",
            "output": [
                "bupropion"
            ]
        },
        {
            "id": "task1447-4a74f596c0ca4297b2bec5cf54306539",
            "input": "Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.",
            "output": [
                "vigabatrin"
            ]
        },
        {
            "id": "task1447-4204fbca366e4fdcabfe259e0b5047ea",
            "input": "The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.",
            "output": [
                "VGB"
            ]
        },
        {
            "id": "task1447-175bd3fffe5d40c6b7fad764ac225555",
            "input": "Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.",
            "output": [
                "Vigabatrin"
            ]
        },
        {
            "id": "task1447-bdf2cba46f474e7691925fda80d11ee8",
            "input": "We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.",
            "output": [
                "VGB"
            ]
        },
        {
            "id": "task1447-e17ec8d086a943bd875a5a7b908476a8",
            "input": "OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.",
            "output": [
                "alfa-interferon"
            ]
        },
        {
            "id": "task1447-9cb0fa2e11064a87a4d4303385e4d8ce",
            "input": "Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-6735008b7629474392a524c3d6f6164c",
            "input": "Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-7c238c0c74d74c5d9d92d5ff39679e83",
            "input": "Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.",
            "output": [
                "tegaserod"
            ]
        },
        {
            "id": "task1447-2951e28567dc4ba384c905cff9340e32",
            "input": "Tegaserod-associated ischemic colitis.",
            "output": [
                "Tegaserod"
            ]
        },
        {
            "id": "task1447-10fe70e728fc43fabbe9065adc0e1f86",
            "input": "Lansoprazole-associated collagenous colitis: a case report.",
            "output": [
                "Lansoprazole"
            ]
        },
        {
            "id": "task1447-6af42335f61644ab8021fd8b39d98f01",
            "input": "The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.",
            "output": [
                "lansoprazole"
            ]
        },
        {
            "id": "task1447-8eebba298ae0471c91f6b0e679d0993b",
            "input": "CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.",
            "output": [
                "pseudoephedrine"
            ]
        },
        {
            "id": "task1447-e19193ed6107484d873e1c1d9fc52071",
            "input": "Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.",
            "output": [
                "phenylpropanolamine"
            ]
        },
        {
            "id": "task1447-95610a22f1ee481493799462b431e65f",
            "input": "Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.",
            "output": [
                "phenylpropanolamine"
            ]
        },
        {
            "id": "task1447-6eb2b92e6558495e9f3d1ad67c87b28d",
            "input": "This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.",
            "output": [
                "pseudoephedrine"
            ]
        },
        {
            "id": "task1447-ff558fced5f34687ad0b545ffebc8939",
            "input": "Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.",
            "output": [
                "quetiapine"
            ]
        },
        {
            "id": "task1447-a602a10caa2246a2b90ebe95968d2b64",
            "input": "Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.",
            "output": [
                "all-trans retinoic acid"
            ]
        },
        {
            "id": "task1447-6c17f251e9074c17bf2a7de9855e87e2",
            "input": "Eruptive epidermoid cysts resulting from treatment with imiquimod.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-7e8255bdce2c4f90af30842a5e49273b",
            "input": "METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.",
            "output": [
                "imiquimod"
            ]
        },
        {
            "id": "task1447-cd6a26df8616491d81147f2c91afc9f9",
            "input": "Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.",
            "output": [
                "iron sucrose"
            ]
        },
        {
            "id": "task1447-ff99b3382fe14651a032fef840ed1380",
            "input": "The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.",
            "output": [
                "iron sucrose"
            ]
        },
        {
            "id": "task1447-2903d47c46374ba5bc8bc2b51e7156d8",
            "input": "Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.",
            "output": [
                "clioquinol"
            ]
        },
        {
            "id": "task1447-1fcfc2e8f08f491c9db5ea4f15caa950",
            "input": "Transient global amnesia after clioquinol: five personal observations from outside Japan.",
            "output": [
                "clioquinol"
            ]
        },
        {
            "id": "task1447-4faae5b96c224799881f5909593853c7",
            "input": "In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.",
            "output": [
                "sodium hyaluronate"
            ]
        },
        {
            "id": "task1447-7a1f5afa557c4e40b094b8d220a37338",
            "input": "Septic knee arthritis after intra-articular hyaluronate injection.",
            "output": [
                "hyaluronate"
            ]
        },
        {
            "id": "task1447-b2c471ad1e1343ac8cde73f227593b82",
            "input": "Acute dystonia induced by lamivudine.",
            "output": [
                "lamivudine"
            ]
        },
        {
            "id": "task1447-0d07bdb744c149faa2b7b26ff86f19c3",
            "input": "ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.",
            "output": [
                "lamivudine"
            ]
        },
        {
            "id": "task1447-330dfe76b5d04fde9d43eac1678600d9",
            "input": "The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.",
            "output": [
                "lamivudine"
            ]
        },
        {
            "id": "task1447-f1d1debcf4654621ac9857935c194798",
            "input": "Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.",
            "output": [
                "pergolide"
            ]
        },
        {
            "id": "task1447-c79544445e8440fe800cfa3b661a6821",
            "input": "OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-73dcaaf14ee5424096bad3ba9c7bb68d",
            "input": "Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-e22951b130b64914b039188ef88242ee",
            "input": "We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-543d8fd1c7be46cdafed8f4825669d66",
            "input": "A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.",
            "output": [
                "MM"
            ]
        },
        {
            "id": "task1447-938544657b7a4935882e7a41f608ed25",
            "input": "Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.",
            "output": [
                "MM"
            ]
        },
        {
            "id": "task1447-5e77ec0bf4364d23a8b9c80506b97e99",
            "input": "Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.",
            "output": [
                "mycophenolate mofetil"
            ]
        },
        {
            "id": "task1447-282cffaf7c09464eb6edef06c1fba881",
            "input": "Primary CNS lymphoma regressed on withdrawal of MM.",
            "output": [
                "MM"
            ]
        },
        {
            "id": "task1447-3565214f85dc4f19aff3d0500feb105a",
            "input": "Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.",
            "output": [
                "Baclofen"
            ]
        },
        {
            "id": "task1447-dde6b721f21647be9b7e2a8bac219910",
            "input": "Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-37e0be02543f494689427ee28812a492",
            "input": "We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-5682676f8148438bad1c104fbbb88287",
            "input": "Can propofol precipitate pancreatitis in patients with Cushing's syndrome?",
            "output": [
                "propofol"
            ]
        },
        {
            "id": "task1447-ba036ae87b5b41f2b3bcb0dd52747bff",
            "input": "Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.",
            "output": [
                "propofol"
            ]
        },
        {
            "id": "task1447-3be901fb06e74fd6b47ecc65e8cae83f",
            "input": "CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-ed286469baaa4f6b909ea5a57de73255",
            "input": "Recently, CD20-negative tumors have been described after Rituximab therapy.",
            "output": [
                "Rituximab"
            ]
        },
        {
            "id": "task1447-d5084cb1c8354b1ab78a043a0a3698e2",
            "input": "Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.",
            "output": [
                "desferrioxamine"
            ]
        },
        {
            "id": "task1447-151701b5af2445bda59c3710b1bcaf15",
            "input": "One of the side-effects of intravitreal triamcinolone is the development of cataract, and it is known that cataract extraction can exacerbate macular degeneration.",
            "output": [
                "triamcinolone"
            ]
        },
        {
            "id": "task1447-f691f40b74ea4393a299e138cd2c032c",
            "input": "Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.",
            "output": [
                "ritodrine hydrochloride"
            ]
        },
        {
            "id": "task1447-ceb6e8dd54da42359e6103bce203ed64",
            "input": "Rhabdomyolysis has been recognized as a complication of tocolytic therapy with ritodrine hydrochloride.",
            "output": [
                "ritodrine hydrochloride"
            ]
        },
        {
            "id": "task1447-b2efe768ce08462ea6cba9fd565fbc4b",
            "input": "We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.",
            "output": [
                "ritodrine-hydrochloride"
            ]
        },
        {
            "id": "task1447-932215e7f84e42fba2a744eea78e1042",
            "input": "Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.",
            "output": [
                "epinephrine"
            ]
        },
        {
            "id": "task1447-de284fa1380e4938bac7acd92de7c855",
            "input": "Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.",
            "output": [
                "epinephrine"
            ]
        },
        {
            "id": "task1447-00c78ecd03084f519ac3a5d7dbed0e68",
            "input": "Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.",
            "output": [
                "levodopa"
            ]
        },
        {
            "id": "task1447-0935cc6ebd54407e9a8c8d728d339dcb",
            "input": "We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.",
            "output": [
                "levodopa"
            ]
        },
        {
            "id": "task1447-50ca1e5f5e6445b984b287af61dd98d3",
            "input": "The major side effect of infliximab is infection.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-1da74fbed06d494399be227d415a6902",
            "input": "This report describes a probable case of infliximab-induced membranous nephropathy.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-8af01421155d48c3b712558dc5db0a04",
            "input": "Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.",
            "output": [
                "Linezolid"
            ]
        },
        {
            "id": "task1447-d36c63ef7b204ead8e6cd66d2cfda435",
            "input": "A selective association between fluoxetine and extensive, prominent eye movements in nonrapid eye movement (NREM) sleep was detected, utilizing Fisher's exact one-tailed statistic (p less than 0.00001 for each comparison).",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-6fb2dcdf9c5c4c1884918743e400cf94",
            "input": "Prominent positive U waves appearing with high-dose intravenous phenylephrine.",
            "output": [
                "phenylephrine"
            ]
        },
        {
            "id": "task1447-cbd67ee236df4b2cba9d1bb74db5ec07",
            "input": "While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.",
            "output": [
                "phenylephrine"
            ]
        },
        {
            "id": "task1447-4d961b260b3d4179aee417d6e209837e",
            "input": "Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.",
            "output": [
                "SRL"
            ]
        },
        {
            "id": "task1447-9096048b7b89460f9da921e2eec8f8de",
            "input": "Sirolimus-associated hepatotoxicity in the kidney graft recipient.",
            "output": [
                "Sirolimus"
            ]
        },
        {
            "id": "task1447-c6e572a2daa5443587b5417c3d757a2f",
            "input": "The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-516cb9f91d13492883a52c607510f6b5",
            "input": "CASE REPORT: We present a case of a 28-yr-old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon beta 1a.",
            "output": [
                "interferon beta 1a"
            ]
        },
        {
            "id": "task1447-7afdac7a279b49f59d744349426957d6",
            "input": "Nephrotic syndrome in a multiple sclerosis patient treated with interferon beta 1a.",
            "output": [
                "interferon beta 1a"
            ]
        },
        {
            "id": "task1447-fce0ddab04e94027865c66e72ceaf63e",
            "input": "SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.",
            "output": [
                "interferon"
            ]
        },
        {
            "id": "task1447-55b43c4baf154a54977329d09903e5c6",
            "input": "This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.",
            "output": [
                "interferons"
            ]
        },
        {
            "id": "task1447-9b9231f1ee1c475a9ed675caacc0298a",
            "input": "Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.",
            "output": [
                "Capecitabine"
            ]
        },
        {
            "id": "task1447-3b5b079c63a54b7a88368f71321b567f",
            "input": "The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-ff9f1d03b92b48be92a0973e8e6a5c40",
            "input": "A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.",
            "output": [
                "venlafaxine"
            ]
        },
        {
            "id": "task1447-c494512b41214991b134739a478e42ec",
            "input": "Venlafaxine-induced urinary incontinence resolved after switching to sertraline.",
            "output": [
                "Venlafaxine"
            ]
        },
        {
            "id": "task1447-de28fc18ea6b464ba568dc9b0ec2c0cc",
            "input": "Diagnosis of hypothyroidism during treatment can be difficult because of the common side effects of alpha interferon.",
            "output": [
                "alpha interferon"
            ]
        },
        {
            "id": "task1447-1c30147c107340168ec2c590ec4e9d7a",
            "input": "Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.",
            "output": [
                "recombinant alpha interferon"
            ]
        },
        {
            "id": "task1447-f3df2904fdb646cd9c3936729f2698d6",
            "input": "Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.",
            "output": [
                "recombinant alpha interferon"
            ]
        },
        {
            "id": "task1447-3a7cecab75d54f07ac96825fdefa1589",
            "input": "Two cases of hypothyroidism in patients with chronic hepatitis C treated with recombinant alpha interferon are reported.",
            "output": [
                "recombinant alpha interferon"
            ]
        },
        {
            "id": "task1447-ec7d194b11554a71be20a793799b03ff",
            "input": "Atrial fibrillation after vardenafil therapy.",
            "output": [
                "vardenafil"
            ]
        },
        {
            "id": "task1447-3786bca0f29b4f1b85300d535547f76a",
            "input": "We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.",
            "output": [
                "vardenafil"
            ]
        },
        {
            "id": "task1447-9f936efd2a9d436781df06894fe7355c",
            "input": "We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-33b05be6408d405cb7f4426334b8dae9",
            "input": "DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.",
            "output": [
                "Interferon alpha-2b"
            ]
        },
        {
            "id": "task1447-81f2f901440e4a149b7ebc38845e6a0c",
            "input": "Reversible cardiomyopathy caused by administration of interferon alpha.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-7168c57df6714e0fbb83a1d68d184527",
            "input": "Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.",
            "output": [
                "senna"
            ]
        },
        {
            "id": "task1447-5e5739a81f6d46459f9ddfa3af35390d",
            "input": "We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.",
            "output": [
                "senna"
            ]
        },
        {
            "id": "task1447-b687b9d5b8a742d4af7a1e9a26dc5a8f",
            "input": "Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-eccdeff5650f4fd48e5cb685c2e043db",
            "input": "Insulin-induced lipohypertrophy: report of a case with histopathology.",
            "output": [
                "Insulin"
            ]
        },
        {
            "id": "task1447-199ef53993474483a745b57ceb3a646f",
            "input": "Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-969ff675c1eb46c6ac9547224d9885d6",
            "input": "To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-eef91434d3e14cf1be7adeace048bbc3",
            "input": "An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.",
            "output": [
                "penicillin"
            ]
        },
        {
            "id": "task1447-13d1af74eaa14d97b8d7be4ca5a4f3dc",
            "input": "CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.",
            "output": [
                "penicillin G"
            ]
        },
        {
            "id": "task1447-b82d11202d314f99946df1402a5ce23c",
            "input": "Penicillin-induced Jarisch-Herxheimer reaction.",
            "output": [
                "Penicillin"
            ]
        },
        {
            "id": "task1447-efe02d2c011b4e8aa1c1997a4f30caa6",
            "input": "Acute respiratory distress syndrome after rituximab infusion.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-be76e186dfd54a4bbcde81883e12ce8d",
            "input": "Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-ba28ee40f1f3498d837e7cd227f2bffd",
            "input": "We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.",
            "output": [
                "bisphosphonate"
            ]
        },
        {
            "id": "task1447-fa71bfb5ae5d4e7e9411a8078910e602",
            "input": "Gemcitabine-related radiation recall in a patient with pancreatic cancer.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-f0800cad27d54afe98eb78340ff55a70",
            "input": "Gemcitabine should be added to the list of drugs known to cause radiation recall.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-bc82257868564748b5b09966eb98d733",
            "input": "Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-5540395ec5af42c5b6e112adae1eabf1",
            "input": "Radiation recall related to gemcitabine has been reported in lung and breast cancer.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-1a0c84d0ad514dd58c3895de2ddfeb74",
            "input": "We suggest discontinuing gemcitabine if radiation recall is observed.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-0779df8a00ee41778251f029f39b8eae",
            "input": "A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-f1eb826ed88048c9ba02f16b81894149",
            "input": "High-dose methotrexate-associated acute renal failure may be an avoidable complication.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-5ed2207d47bd451fb2cce92b5a83dba7",
            "input": "Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-5e0fe0665d9f431da55e096d3ca1f7a0",
            "input": "Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.",
            "output": [
                "calcium hydroxylapatite"
            ]
        },
        {
            "id": "task1447-1c76d60a6b354a3d8e4c6ee79a2f1f4a",
            "input": "To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.",
            "output": [
                "calcium hydroxylapatite"
            ]
        },
        {
            "id": "task1447-150791c09eb04b74beaba0252d7eedae",
            "input": "CASE SUMMARY: A 57-year-old female with cardiomyopathy and \"sulfa\" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.",
            "output": [
                "furosemide"
            ]
        },
        {
            "id": "task1447-6a2fc966efcb41f2b8dd05f9ace20d25",
            "input": "In addition, while cases of loop diuretic-induced pancreatitis, including furosemide, have been published, the allergic manifestations with both sulfonamide antibiotics and non-antibiotics in our patient suggest possible cross-reactivity between these 2 drug classes.",
            "output": [
                "furosemide"
            ]
        },
        {
            "id": "task1447-48c34355a017494cadb03bfabfbed281",
            "input": "Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.",
            "output": [
                "Torsemide"
            ]
        },
        {
            "id": "task1447-aaaa99d6aa234a92880da8ee58bda1f2",
            "input": "On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-4ac94dbb3f21403da695437621313cb2",
            "input": "When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-6f5dcd6e04e4415fb3aec17006fd6562",
            "input": "After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.",
            "output": [
                "prostaglandin E1"
            ]
        },
        {
            "id": "task1447-3749871361cc40a1acabea6b209f3c7a",
            "input": "Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.",
            "output": [
                "cyclosporine"
            ]
        },
        {
            "id": "task1447-423edc00d4d041069a789ddfcd46caa1",
            "input": "After intravitreal injection of triamcinolone acetonide, cataract may rapidly develop in eyes that have been intensively treated, topically and systemically, by corticosteroids for several years.",
            "output": [
                "triamcinolone acetonide"
            ]
        },
        {
            "id": "task1447-6068262c2eac4fbea2e1c75314eb4f07",
            "input": "Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.",
            "output": [
                "IFN-beta"
            ]
        },
        {
            "id": "task1447-690a1bff4c644764be483d8edfc660b6",
            "input": "The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.",
            "output": [
                "IFN-beta"
            ]
        },
        {
            "id": "task1447-d61384f276244b32ae421284e36c71a0",
            "input": "Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.",
            "output": [
                "IFN-beta"
            ]
        },
        {
            "id": "task1447-d1b904030f5441f48d27b7aceddded89",
            "input": "We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.",
            "output": [
                "IFN-beta"
            ]
        },
        {
            "id": "task1447-9e26ef3f17c247be9860fbca3137a9d6",
            "input": "Trimethoprim-sulfamethoxazole-induced aseptic meningitis.",
            "output": [
                "Trimethoprim-sulfamethoxazole"
            ]
        },
        {
            "id": "task1447-21583fbfaa884b18b728fede3266724d",
            "input": "In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.",
            "output": [
                "corticosteroid"
            ]
        },
        {
            "id": "task1447-1ae8f0cc997147838f34582217e2fe7d",
            "input": "Chloroquine-induced bilateral ptosis.",
            "output": [
                "Chloroquine"
            ]
        },
        {
            "id": "task1447-5ea087db923545b2b1a72197ba4a5f17",
            "input": "This report describes a case of bilateral ptosis induced by chloroquine.",
            "output": [
                "chloroquine"
            ]
        },
        {
            "id": "task1447-72d3ae1caabf484d800927b251bfb4c1",
            "input": "DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-e6bf4ce1aac94fd48e8764a6702b157c",
            "input": "Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-c3e4a4783a5f4296af9cda0628d68611",
            "input": "Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-bca3f4dcb5b24e03bb5191e98fd19028",
            "input": "This is a rare case of ARDS associated with lithium intoxication.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-91746a4ba2a14db490297e3193e78b82",
            "input": "CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the \"indirect\" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.",
            "output": [
                "L-dopa"
            ]
        },
        {
            "id": "task1447-4c46daab27544be39621800bf7e253ef",
            "input": "Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.",
            "output": [
                "levodopa"
            ]
        },
        {
            "id": "task1447-626e3ae8f99e462bb3c101efd13e14c1",
            "input": "A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.",
            "output": [
                "triazolam"
            ]
        },
        {
            "id": "task1447-5cb2bd7e2d054a7aa8a0d2365b737d05",
            "input": "Although interferon gamma has been implicated in the pathogenesis of sarcoidosis, only a few cases of sarcoidosis associated with interferon alpha therapy have been reported.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-ea726b75d06746beb3c414fd89ecb88a",
            "input": "In this paper, we report a case of severe hypercalcemia of immobilization in a 40-year-old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH-II (PTH>1,000 pg/mL).",
            "output": [
                "cinacalcet HCl"
            ]
        },
        {
            "id": "task1447-8a7eed6f21b34590a030ad090d3d35de",
            "input": "Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-0ae66d0d97454f19a78bc79e77627acd",
            "input": "Reversible sirolimus-associated pneumonitis after heart transplantation.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-df650e1700ca4ad68c6d4ab768285b62",
            "input": "Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-15322ff1f07845d09317c89b7d6bfe05",
            "input": "An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-71089973de4343f48d7ee59202fcaa08",
            "input": "CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-faf2c256dd5c426ea59d73ab1467629a",
            "input": "CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-c174f05e49ff4eec8c6d8d6997ddcde2",
            "input": "NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-e3274913044b4635bb0643196c5e743a",
            "input": "Nonconvulsive status epilepticus due to ifosfamide.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-fa99c1299f6b4575b02e6d3e22a3caad",
            "input": "Cutaneous mycobacterial infection post intravesical BCG installation.",
            "output": [
                "BCG"
            ]
        },
        {
            "id": "task1447-231c8b60267243e8b674f73dbd8b5afa",
            "input": "Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.",
            "output": [
                "BCG"
            ]
        },
        {
            "id": "task1447-f77605d28c9c4dbba8374b2c2a9c2def",
            "input": "Some patients develop hypersensitivity rash in response to HCQ.",
            "output": [
                "HCQ"
            ]
        },
        {
            "id": "task1447-a2036cbc5b2e4f09a7b2db03d7649676",
            "input": "Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-85f9efa421d84e99819ddb9a7aeecf63",
            "input": "This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.",
            "output": [
                "TMP-SMX"
            ]
        },
        {
            "id": "task1447-b72d5411b272409dbb8b3cff4b938a41",
            "input": "Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.",
            "output": [
                "Trimethoprim-sulfamethoxazole"
            ]
        },
        {
            "id": "task1447-db2348cf334f46f39376f4f510d975ae",
            "input": "Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-2bc5828be9ea4a6db653f460d93f7fc6",
            "input": "Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.",
            "output": [
                "Interferon-alpha"
            ]
        },
        {
            "id": "task1447-60aae925123c47e29b39a7726c3067b5",
            "input": "Dipyrone-induced granulocytopenia: a case for awareness.",
            "output": [
                "Dipyrone"
            ]
        },
        {
            "id": "task1447-39acdbdfd0f843ce93cd42e686068add",
            "input": "We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.",
            "output": [
                "dipyrone"
            ]
        },
        {
            "id": "task1447-7ac2021ba3da4fcdafe9b1dbbcc0bb1d",
            "input": "Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.",
            "output": [
                "sulfadiazine"
            ]
        },
        {
            "id": "task1447-65661b6ebeb44cebbd5eba1a33228455",
            "input": "This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.",
            "output": [
                "sulfadiazine"
            ]
        },
        {
            "id": "task1447-d2e0959e47214892b19c60ae95ae616a",
            "input": "Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.",
            "output": [
                "paclitaxel"
            ]
        },
        {
            "id": "task1447-a55e86577d194158b73be9ac5ec8da14",
            "input": "Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids.",
            "output": [
                "paclitaxel"
            ]
        },
        {
            "id": "task1447-bd0d99291c304dd89ef1a2fe55014135",
            "input": "Infections are a major adverse effect during the treatment with anti-TNF-alpha.",
            "output": [
                "anti-TNF-alpha"
            ]
        },
        {
            "id": "task1447-e3e97e1a9e5c45b1a3cea309a4bbcc4c",
            "input": "In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-f8303da6a17f4b02bcfd97ada605be79",
            "input": "Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-7507c2b7f55c414eab622dc4cc927258",
            "input": "Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.",
            "output": [
                "phenol"
            ]
        },
        {
            "id": "task1447-cf43b20888f7491fa993e260dab2295f",
            "input": "We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.",
            "output": [
                "phenol"
            ]
        },
        {
            "id": "task1447-5b0d312718724beea537d767a945a5d4",
            "input": "Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.",
            "output": [
                "IFN beta"
            ]
        },
        {
            "id": "task1447-6d23863225fc43c88e4deaf5c35302db",
            "input": "Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.",
            "output": [
                "cloxacillin"
            ]
        },
        {
            "id": "task1447-d23589f93ff140edb3d063c83410faa2",
            "input": "Cardiac toxicity related to BCNU has not been described well.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-c7186d8e729a4bf38cdfdb9e9dd1d344",
            "input": "Myocardial ischemia associated with high-dose carmustine infusion.",
            "output": [
                "carmustine"
            ]
        },
        {
            "id": "task1447-c0290bc6ec1643909cecd4c80002e42a",
            "input": "Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-a0bf27525039463a8355764a7f93eb06",
            "input": "Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-075615d869ce4373b86cb943b1cc8785",
            "input": "We present a case of hypereosinophilia related to zafirlukast therapy.",
            "output": [
                "zafirlukast"
            ]
        },
        {
            "id": "task1447-1c3258ed48db4cb1bd99561a1b92a101",
            "input": "A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.",
            "output": [
                "statin"
            ]
        },
        {
            "id": "task1447-dc1076e5c6384430a53b477fbd9e17b2",
            "input": "Statin-associated myasthenia gravis: report of 4 cases and review of the literature.",
            "output": [
                "Statin"
            ]
        },
        {
            "id": "task1447-dcde1dfc89d9468f80bf5ac8e053407a",
            "input": "We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug.",
            "output": [
                "statin"
            ]
        },
        {
            "id": "task1447-bb95ac72a6204701bdbae5fbbea6683c",
            "input": "Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-ed576cc3cebc4ed484656212e73006ae",
            "input": "After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.",
            "output": [
                "HCQ"
            ]
        },
        {
            "id": "task1447-bb20d72a7d014307888b750c48a366b3",
            "input": "CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.",
            "output": [
                "HCQ"
            ]
        },
        {
            "id": "task1447-c0ea58a8685f43d895d8da83d9f93a3f",
            "input": "We report a case of chronic use of HCQ associated with torsade de pointes.",
            "output": [
                "HCQ"
            ]
        },
        {
            "id": "task1447-cb219dd83850439fa5ce4ccb60b049d1",
            "input": "CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-6e44ecea9c3c4f2bb39b4e23e6cc79d9",
            "input": "Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-8325176ba0ba4589b2801284f7f73508",
            "input": "An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-58ea80bcdc474c1b8b17a0750b114f26",
            "input": "The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-b4a2cd30792c4c9da3383bfedaf0743d",
            "input": "Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-93cf5a2e38b240c9b3e67ddf7f6b0574",
            "input": "Cutaneous eruptions occur in 3% of individuals administered carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-df6a9ad95d034774b28250194701576b",
            "input": "We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-11889066dbb4445c807489438e9fafc8",
            "input": "First case of ivermectin-induced severe hepatitis.",
            "output": [
                "ivermectin"
            ]
        },
        {
            "id": "task1447-7fc20f485b2b4dafa187ddb1c08e0880",
            "input": "To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.",
            "output": [
                "ivermectin"
            ]
        },
        {
            "id": "task1447-66e4c30b45644923a642e90ac4a9add9",
            "input": "We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.",
            "output": [
                "ivermectin"
            ]
        },
        {
            "id": "task1447-df96722f05ba4cd494abb2f1a9c6a028",
            "input": "CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-ec8d060b03bb41aa936f64e05eb20932",
            "input": "Gemcitabine-induced rectus abdominus radiation recall.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-64ce796ddb6d45bd92c69bb7525c905b",
            "input": "Sporadic rippling muscle disease unmasked by simvastatin.",
            "output": [
                "simvastatin"
            ]
        },
        {
            "id": "task1447-e3ebe9d6493047ba9b816e02244614af",
            "input": "Acute coronary syndrome induced by capecitabine therapy.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-a47c0f13aa2746529ec579aa31125413",
            "input": "This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.",
            "output": [
                "Capecitabine"
            ]
        },
        {
            "id": "task1447-c83cbc8b1be54cc3aa0a3f215eb531f2",
            "input": "The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.",
            "output": [
                "pegvisomant"
            ]
        },
        {
            "id": "task1447-0980c19b373346e3a07bba1a3ace4030",
            "input": "PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.",
            "output": [
                "Topiramate"
            ]
        },
        {
            "id": "task1447-6ba947a5638e4ee5a146b2545a804b39",
            "input": "Spontaneous splenic infarction associated with sumatriptan use.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-ce3c347a225e4b30b8076181a9ac7aab",
            "input": "We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-2e6073a4b28444fd964d7a4067ce9f71",
            "input": "Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-75c6c81d1a7e458ab14c2576027fadc0",
            "input": "Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.",
            "output": [
                "radioiodine"
            ]
        },
        {
            "id": "task1447-12eb04a4f44041898f57572863da48b5",
            "input": "We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.",
            "output": [
                "glucocorticoids"
            ]
        },
        {
            "id": "task1447-1c36812c444a458f9d348428cd120077",
            "input": "Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.",
            "output": [
                "sulphasalazine"
            ]
        },
        {
            "id": "task1447-5163f1b5ce2e4eccb8ea35ce756c5cf0",
            "input": "Five days after the fourth dose of vincristine, she presented with bilateral ptosis.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-0085e9e2ec1f4ff69fc191558a7b9417",
            "input": "Vincristine induced cranial polyneuropathy.",
            "output": [
                "Vincristine"
            ]
        },
        {
            "id": "task1447-e3744da0de794e46aa8b94bcd0086892",
            "input": "We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-7d759273bd654afaaf1058a4758615ea",
            "input": "Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-7c30f8ec34da4639bb6dc574edc7f8e4",
            "input": "We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-37c56fce3278443bb9df74a0b7c7c44b",
            "input": "Olanzapine-associated neuroleptic malignant syndrome.",
            "output": [
                "Olanzapine"
            ]
        },
        {
            "id": "task1447-a660e5aa5b4946fc8ffb1fd9fc1cfa0f",
            "input": "Allergic contact angioedema to benzoyl peroxide.",
            "output": [
                "benzoyl peroxide"
            ]
        },
        {
            "id": "task1447-a44feeb5128542bea7d146f39cf321fe",
            "input": "Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.",
            "output": [
                "BP"
            ]
        },
        {
            "id": "task1447-1d187da476144cd9a7e727b2c8322e58",
            "input": "Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-8e32ab23a4f14f07ab72dcb82b8bb560",
            "input": "We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.",
            "output": [
                "caffeine"
            ]
        },
        {
            "id": "task1447-48df6323bf084f5d8bc39983c8a0495a",
            "input": "It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-e0c1ee8d183640ceb0f5a1feb6a590c7",
            "input": "Severe dapsone hypersensitivity syndrome.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-00433ad783654365a5aa7bd7e64a4825",
            "input": "We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-01d929e6915a4f25a46bdd16dcf02f29",
            "input": "Anaphylaxis to intrathecal diamorphine.",
            "output": [
                "diamorphine"
            ]
        },
        {
            "id": "task1447-c4bb10ebdba64803afe672ecd4d8b122",
            "input": "We believe this is the first report of intrathecal diamorphine causing anaphylaxis.",
            "output": [
                "diamorphine"
            ]
        },
        {
            "id": "task1447-f60a7b6a14d6497ea86749a3f0966c4e",
            "input": "We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.",
            "output": [
                "aprotinin"
            ]
        },
        {
            "id": "task1447-d27f2c056dde451ab1f9bbd7a57fd273",
            "input": "Localized purpura associated with lamotrigine.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-38df8c1b38fa46ecb9aa2b327ff9faa2",
            "input": "This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-498641be479645278f9f2e5b7dd9db6c",
            "input": "This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-54e0e19ad77f43e1b759f1a224b625ea",
            "input": "Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-4e17aeed314d455f92c2f4658017bd59",
            "input": "Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-0bf37477716c4a7182e4c875f1c4199a",
            "input": "Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-6fcba560b3c5470e9ec3f10d6b58715d",
            "input": "We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-7154027a57624445884a77ce8ceb9e56",
            "input": "Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.",
            "output": [
                "thrombin"
            ]
        },
        {
            "id": "task1447-aa41c5be4ed8416fa8bf54d2d73bf48d",
            "input": "Lower extremity arterial thrombosis following sonographically guided thrombin injection of a femoral pseudoaneurysm.",
            "output": [
                "thrombin"
            ]
        },
        {
            "id": "task1447-d908eb8e8f7c48c7ac680e6b945609e0",
            "input": "Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.",
            "output": [
                "thrombin"
            ]
        },
        {
            "id": "task1447-c0e0c15797564dc386f99eb2333491a4",
            "input": "We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.",
            "output": [
                "thrombin"
            ]
        },
        {
            "id": "task1447-16b095dbcd0e41119c9539e45bea6dd4",
            "input": "A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.",
            "output": [
                "oxaliplatin"
            ]
        },
        {
            "id": "task1447-3e8ab8c4d449443db356b0c86e0bd75e",
            "input": "Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.",
            "output": [
                "oxaliplatin"
            ]
        },
        {
            "id": "task1447-2c277f373e964e1ab122ae8cea207c3c",
            "input": "Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-95f3014125444898bc92dc6be4c69ed5",
            "input": "Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.",
            "output": [
                "mirtazapine"
            ]
        },
        {
            "id": "task1447-b6e2fed0e6324216968b9018345409ad",
            "input": "A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration).",
            "output": [
                "interferon (IFN)-beta-1b"
            ]
        },
        {
            "id": "task1447-c3199f62e996496ab390b55e381a9381",
            "input": "Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.",
            "output": [
                "interferon-beta-1b"
            ]
        },
        {
            "id": "task1447-204dcee9a9b54e96b2fd8c3ddaf506ee",
            "input": "A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.",
            "output": [
                "homochlorcyclizine hydrochloride"
            ]
        },
        {
            "id": "task1447-6d8d0074922641f18a39b53e17af4e05",
            "input": "Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.",
            "output": [
                "calcium stearate"
            ]
        },
        {
            "id": "task1447-038e7f08a4ba4cbc953f62266d80c12d",
            "input": "Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.",
            "output": [
                "calcium stearate"
            ]
        },
        {
            "id": "task1447-7993e469df6347979e46e704475f31ce",
            "input": "Scleritis complicating zoledronic acid infusion.",
            "output": [
                "zoledronic acid"
            ]
        },
        {
            "id": "task1447-a33ce0ac801f40f287d5942fe8059b2c",
            "input": "We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.",
            "output": [
                "zoledronic acid"
            ]
        },
        {
            "id": "task1447-04a6bff1e91b4624b855b22b5408258f",
            "input": "Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-d2dc1025c06a4354807b84f97873bc2c",
            "input": "Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-7d88a40fef834bd58d044eb979988d1b",
            "input": "This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-b389a71888934a2a810682898683963b",
            "input": "An intertrigo-like eruption from pegylated liposomal doxorubicin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-481121c6bbb140a994f3bd6c44a80ae8",
            "input": "This eruption appears to be a distinct cutaneous toxicity of PLD.",
            "output": [
                "PLD"
            ]
        },
        {
            "id": "task1447-30cecb0f9ed1446599c19a5188065da9",
            "input": "Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.",
            "output": [
                "indomethacin"
            ]
        },
        {
            "id": "task1447-6c59b4e3292944dbb4f84ad4a8bf4f7b",
            "input": "Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin.",
            "output": [
                "indomethacin"
            ]
        },
        {
            "id": "task1447-cd1fd0dcea734d4eb5f629d2767d9835",
            "input": "CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.",
            "output": [
                "moxifloxacin"
            ]
        },
        {
            "id": "task1447-db07f5a37c55422a90c8334700f87502",
            "input": "RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.",
            "output": [
                "moxifloxacin"
            ]
        },
        {
            "id": "task1447-03c6fa3b66d1432fa472a189afe1d0be",
            "input": "Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.",
            "output": [
                "fluoroquinolone"
            ]
        },
        {
            "id": "task1447-ff94ecd54cae466caf746e92b3569729",
            "input": "Acute generalized exanthematous pustulosis induced by nimesulide.",
            "output": [
                "nimesulide"
            ]
        },
        {
            "id": "task1447-6cba512406b247168562db624141500e",
            "input": "OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-2b9074d9f9364becb97bfb70197c1412",
            "input": "Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.",
            "output": [
                "amphotericin B deoxycholate"
            ]
        },
        {
            "id": "task1447-fdea256677b347f2921cc01f2d3965c6",
            "input": "The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement.",
            "output": [
                "benfluorex"
            ]
        },
        {
            "id": "task1447-64092090eafb4c1aa9cc58b8431721ee",
            "input": "Valvular heart disease in a patient taking benfluorex.",
            "output": [
                "benfluorex"
            ]
        },
        {
            "id": "task1447-b06a06e15ed846df9884357cb0735c5b",
            "input": "Liver transplantation for fulminant hepatitis related to nevirapine therapy.",
            "output": [
                "nevirapine"
            ]
        },
        {
            "id": "task1447-2ffb2405a814446bbf7c47466981aa8a",
            "input": "The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.",
            "output": [
                "cyclosporin"
            ]
        },
        {
            "id": "task1447-a089cfa2a1564989b89ebe4abaea478c",
            "input": "Hepatotoxicity induced by cyproterone acetate: a report of three cases.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-8235aab943d64e279c2d09fd2e309d3d",
            "input": "Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.",
            "output": [
                "CPA"
            ]
        },
        {
            "id": "task1447-0b8a41b3af2c4b39a7aab714befc5360",
            "input": "Leishmania infantum leishmaniasis in corticosteroid--treated patients.",
            "output": [
                "corticosteroid"
            ]
        },
        {
            "id": "task1447-00b61d8575e8435f801ae113344d02e9",
            "input": "However, an association of Ritalin with glaucoma has been reported.",
            "output": [
                "Ritalin"
            ]
        },
        {
            "id": "task1447-6f1fd78921094b6889900285e4e69816",
            "input": "PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.",
            "output": [
                "Avastin"
            ]
        },
        {
            "id": "task1447-223cd8b75f5e4a638a41a89ea7f23b52",
            "input": "Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-4016569f1af14af28e018e8d9899720b",
            "input": "A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-0c96d840359346d68f4521390042aa73",
            "input": "A case of oculogyric crisis induced by metoclopramide is described in this paper.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-f408f4e7760248fe8782f5b4bc6e88d6",
            "input": "However, cyclosporine dependency is associated with the risk of nephrotoxicity.",
            "output": [
                "cyclosporine"
            ]
        },
        {
            "id": "task1447-bedea794686847f789057d682182ce49",
            "input": "The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.",
            "output": [
                "adriamycin"
            ]
        },
        {
            "id": "task1447-4412fba221354994afd5aa8f8dd94b88",
            "input": "We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.",
            "output": [
                "mesalazine"
            ]
        },
        {
            "id": "task1447-7b65b56176c847b5b08474b34fe0f6ff",
            "input": "Acute drug induced hepatitis due to erlotinib.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-7eac3277fb1e49748fe900be4e5d7e0f",
            "input": "CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-036027b77d9a4e86b9d3bf319d6ad21b",
            "input": "Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-0816aa4258874cd48c0478a3a6cf3b23",
            "input": "Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.",
            "output": [
                "docetaxel"
            ]
        },
        {
            "id": "task1447-c5a7787e2e4a41338601f6161d3147bc",
            "input": "Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.",
            "output": [
                "docetaxel"
            ]
        },
        {
            "id": "task1447-7bf44c28547247b694d09de442018ab4",
            "input": "The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.",
            "output": [
                "docetaxel"
            ]
        },
        {
            "id": "task1447-93c5ed82ff5b4f699e5daed6f4a14c32",
            "input": "Juvenile absence epilepsy exacerbated by valproic acid.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-b7e554f21ccf4b61980b53da6ccfbe3d",
            "input": "CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-d9525c2b831a45698f480ea9f52b8cfd",
            "input": "PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-55bba5c208474a64a5f84daf9c56fb83",
            "input": "Pulmonary hypertension during lithium therapy: clinical case study.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-eef60e437fd8425da312e5282039d422",
            "input": "The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-1343aba616644df2869813a456f8c7a1",
            "input": "This is the first report of pulmonary hypertension in an adult patient during lithium therapy.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-06f6cd3a730e44a2bf85f9d8eee32c03",
            "input": "The patient's arthritis flared after the second infusion of infliximab, which was discontinued.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-d8d23b988011483e9b2fcd94e066b49a",
            "input": "The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.",
            "output": [
                "perospirone hydrochloride"
            ]
        },
        {
            "id": "task1447-504e4175205b44e1bab4c7664bfc7092",
            "input": "Fatal venous thrombembolism complicating imatinib therapy in a patient with metastatic gastrointestinal stromal tumor.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-de2a7d4c94cd4621a506276f05e9c730",
            "input": "The possibility of deep vein thrombosis caused by the compression of the veins by necrotic tumor should be considered in patients with abdominal or pelvic metastases of GIST, including patients treated with imatinib.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-6b83f01f97904e47b5e8ffba87e5ea65",
            "input": "Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.",
            "output": [
                "methadone"
            ]
        },
        {
            "id": "task1447-ca1416e980454f40888de45fc748e323",
            "input": "We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.",
            "output": [
                "methadone"
            ]
        },
        {
            "id": "task1447-8b1a79f9dfe3442daa6afb43814cce8b",
            "input": "The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.",
            "output": [
                "bisphosphonate"
            ]
        },
        {
            "id": "task1447-348e92b8f70f4be4ae18d89bece7527d",
            "input": "Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-be4a9f5f8ac4470f9bce28b9f737a61f",
            "input": "We report a patient who developed acute pancreatitis during amiodarone therapy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-f5f8b75ad070428d8146fe6cb121c594",
            "input": "DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-41604c03b3384c478ea1a3cc0fa17136",
            "input": "Tuberculous uveitis after treatment with etanercept.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-164eb53c05f94a08ab10a4f328ad8e2c",
            "input": "We report the first case of tuberculous uveitis due to etanercept.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-15f49694b70645028ed517daec4d7e06",
            "input": "Osteomyelitis occurring during infliximab treatment of severe psoriasis.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-4d93da68cbcb49e58343d23b4ebb9764",
            "input": "CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.",
            "output": [
                "fentanyl"
            ]
        },
        {
            "id": "task1447-3af8a3795982401c951b5a33bb63a542",
            "input": "Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-0659ab3c4ddb40dcb4d6c07025e4dfc5",
            "input": "Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.",
            "output": [
                "Docetaxel"
            ]
        },
        {
            "id": "task1447-e92bc4bfdf3a47b3bda463afa715134e",
            "input": "We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.",
            "output": [
                "docetaxel"
            ]
        },
        {
            "id": "task1447-ca197c44a6d34fe3a4eaa42bf40a8761",
            "input": "A case of recall pneumonitis induced by gemcitabine is reported.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-9aec1c095a6b43249063274fd8606b14",
            "input": "CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-b85fa2a221c84c33a253d3faf3c011fd",
            "input": "Radiation recall pneumonitis induced by gemcitabine.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-8c6bf180774e473caaaa3fd1539802fe",
            "input": "CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-6d6fcb015a914bc7ad39dcb1433c587c",
            "input": "However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.",
            "output": [
                "teicoplanin"
            ]
        },
        {
            "id": "task1447-6fa72b5f0f2b49c09e192ae01aee3b5a",
            "input": "Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.",
            "output": [
                "pentamidine"
            ]
        },
        {
            "id": "task1447-1a1f0cb264ce492e85472621b2bb37df",
            "input": "Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.",
            "output": [
                "interferon alpha 2-beta"
            ]
        },
        {
            "id": "task1447-751520ca6d78442db4ba8c197a90569a",
            "input": "Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.",
            "output": [
                "Flecainide"
            ]
        },
        {
            "id": "task1447-eea84e22b14b49deaa655b6c91a9688d",
            "input": "Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.",
            "output": [
                "flecainide"
            ]
        },
        {
            "id": "task1447-d163d4761c514ca28a5c1d17e6d5350b",
            "input": "Ezetimibe-induced acute pancreatitis.",
            "output": [
                "Ezetimibe"
            ]
        },
        {
            "id": "task1447-8636bac622e34042aed1b39689e3f755",
            "input": "Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.",
            "output": [
                "ezetimibe"
            ]
        },
        {
            "id": "task1447-51c9e5e86d7f441cb34e45ef02eb3d57",
            "input": "Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-c66c985ab504469aa9e885f6d49e9085",
            "input": "This is the first histologically confirmed case of NASH that was aggravated by raloxifene.",
            "output": [
                "raloxifene"
            ]
        },
        {
            "id": "task1447-aada7984eaae4d81b02677b17119e5c2",
            "input": "A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.",
            "output": [
                "Danazol"
            ]
        },
        {
            "id": "task1447-a7e6661bca3a465aac17f06261295b51",
            "input": "Hepatic damage after danazol treatment.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-414db157fcd4499ea16c2a4c88b0e9b6",
            "input": "Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.",
            "output": [
                "lenalidomide"
            ]
        },
        {
            "id": "task1447-bf65a7592a2445428e7deb4988200ad2",
            "input": "Thus, the patient's clinical course and workup strongly support a diagnosis of lenalidomide-induced hypersensitivity pneumonitis-like syndrome.",
            "output": [
                "lenalidomide"
            ]
        },
        {
            "id": "task1447-d9029b8f18994f48895c178e5392b434",
            "input": "Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.",
            "output": [
                "triamcinolone"
            ]
        },
        {
            "id": "task1447-b6d1fc4e7c2040c9985bc38ea2f63738",
            "input": "A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-77a738c1c6464463a130e97692d9798d",
            "input": "Ethambutol toxicity manifesting as acute onset psychosis.",
            "output": [
                "Ethambutol"
            ]
        },
        {
            "id": "task1447-191055c28396415f8e3e679afeb40af2",
            "input": "Psoriasis induced by interferon-alpha.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-f4216e636e114796a90b8bb69e713355",
            "input": "Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.",
            "output": [
                "Recombinant human interferon-alpha"
            ]
        },
        {
            "id": "task1447-87cee17e050b4779b01d7e68f72e8c8f",
            "input": "We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.",
            "output": [
                "interferon-alpha"
            ]
        },
        {
            "id": "task1447-33cf6606609344da9556e890dd0437a6",
            "input": "Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-616341af0b6541f4941c35d2e7ba04be",
            "input": "Bleomycin induced hyperpigmentation with yolk sac tumor.",
            "output": [
                "Bleomycin"
            ]
        },
        {
            "id": "task1447-9f616a039c6b4ef9a7140190b8fa836f",
            "input": "The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-a78347724ecf4787be7a55c71165936d",
            "input": "A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-8d3ee11962624e4bac995f27f758bd3f",
            "input": "BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-7b878bbeb53342acbc4c2524dc2e558d",
            "input": "Capecitabine-induced headache responding to diltiazem.",
            "output": [
                "Capecitabine"
            ]
        },
        {
            "id": "task1447-e974917742de48edb71f939e0f87deba",
            "input": "The patient developed grade 3 capecitabine-induced headache.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-ac5dbeaa502a450a998511f677f93bde",
            "input": "We hypothesize that capecitabine-induced headache is vascular in nature.",
            "output": [
                "capecitabine"
            ]
        },
        {
            "id": "task1447-03748ef5bc9c494c9ab0d423944fd03f",
            "input": "Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.",
            "output": [
                "bortezomib"
            ]
        },
        {
            "id": "task1447-08b8bda381604ccca2f90defbdd6b39a",
            "input": "We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.",
            "output": [
                "bortezomib"
            ]
        },
        {
            "id": "task1447-b3d12cb59a844e5c8b7bfaa1265a6442",
            "input": "A woman developed delusional parasitosis when taking phenelzine.",
            "output": [
                "phenelzine"
            ]
        },
        {
            "id": "task1447-c15dd4254acc45618a537358bc49346f",
            "input": "Delusional parasitosis associated with phenelzine.",
            "output": [
                "phenelzine"
            ]
        },
        {
            "id": "task1447-16f41187aeea43e39e06695853debb26",
            "input": "The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-cc901fbca79d4e83940b8ad81764bc40",
            "input": "Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-42578c84ae094e61ab31eeac3ada1ff6",
            "input": "We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-02ed34bb9a1347a1af0f6db883739203",
            "input": "The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.",
            "output": [
                "PGE1"
            ]
        },
        {
            "id": "task1447-4cf54ce1ca2046d8a2055bf10512c43a",
            "input": "The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.",
            "output": [
                "PGE1"
            ]
        },
        {
            "id": "task1447-c22ee6c992b542679379b9a01b8ad748",
            "input": "A case of colchicine-induced rhabdomyolysis is reported.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-befccdd7485949cdb4f12a96e469f0fd",
            "input": "Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-13e57eb794f74219a7d8d65bffdd0245",
            "input": "Colchicine-induced rhabdomyolysis.",
            "output": [
                "Colchicine"
            ]
        },
        {
            "id": "task1447-0085c9ef5b424e5e8c6afbd1075d4a0f",
            "input": "Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-506e6930f9854fd789cfe7adb3595f16",
            "input": "5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.",
            "output": [
                "5-Fluorouracil"
            ]
        },
        {
            "id": "task1447-02c9d9fa7cfd456db58838b50e5266c2",
            "input": "CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.",
            "output": [
                "Acetic acid"
            ]
        },
        {
            "id": "task1447-f9f489a3a8ce4489a7d178a7134b0237",
            "input": "Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.",
            "output": [
                "interferon-gamma"
            ]
        },
        {
            "id": "task1447-1446c89aa65f4220a417daaba990070a",
            "input": "We assume that rIFN-gamma induced the de novo development of SLE in our patient.",
            "output": [
                "rIFN-gamma"
            ]
        },
        {
            "id": "task1447-56e7136c45e9465a9f884534f4fc99d9",
            "input": "Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.",
            "output": [
                "Bisphosphonate"
            ]
        },
        {
            "id": "task1447-96268623508641a58f06c85a4f504426",
            "input": "Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.",
            "output": [
                "Clozapine"
            ]
        },
        {
            "id": "task1447-535a1428d3fb47d3b20fd4d179bb59e3",
            "input": "Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-f1d454a667964cd799e2a9ce1d46bedb",
            "input": "Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-022d5f8f491e40c89b509fcefd163f8f",
            "input": "Metformin-associated lactic acidosis precipitated by diarrhea.",
            "output": [
                "Metformin"
            ]
        },
        {
            "id": "task1447-bc6b3dfd01c84d5eb7bb8182ee5f4553",
            "input": "The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.",
            "output": [
                "MMF"
            ]
        },
        {
            "id": "task1447-81e3f55ec6604721af5f9041bffc3b6c",
            "input": "A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.",
            "output": [
                "oxcarbazepine"
            ]
        },
        {
            "id": "task1447-0a8862cdbee7489bad0347c8077e4d51",
            "input": "Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.",
            "output": [
                "oxcarbazepine"
            ]
        },
        {
            "id": "task1447-01db1dc74c914cbd9ff564e505b9bf1e",
            "input": "Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.",
            "output": [
                "Oxcarbazepine"
            ]
        },
        {
            "id": "task1447-cc95ca48cabd48428f09c4992a001a5c",
            "input": "We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.",
            "output": [
                "oxcarbazepine"
            ]
        },
        {
            "id": "task1447-032fd06f95404023b4d5a821ddf283f3",
            "input": "Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-e9702b5e2af942e3a0e310d83ab69694",
            "input": "One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.",
            "output": [
                "tacrolimus"
            ]
        },
        {
            "id": "task1447-930e97ce73394f5fa8ee4f937db73f9a",
            "input": "Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-f34921645e3642f68bb9c0a513843cbf",
            "input": "A patient with chronic myelomonocytic leukemia developed drug-induced pulmonary toxicity after using low dose oral etoposide.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-f3b89adc979d42d4bb0e3ff87b19a1ff",
            "input": "Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-da17a6eb6dda47bcb52fa07e937e9d45",
            "input": "PET scintigraphy of etoposide-induced pulmonary toxicity.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-64b2169c36d74639bb972649c7c7647e",
            "input": "Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.",
            "output": [
                "L-tryptophan"
            ]
        },
        {
            "id": "task1447-9491e4b97472464abb8d49105fc970e9",
            "input": "The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.",
            "output": [
                "L-tryptophan"
            ]
        },
        {
            "id": "task1447-6435c47671264ec78a3a2393250ef793",
            "input": "Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.",
            "output": [
                "RFP"
            ]
        },
        {
            "id": "task1447-14ef0a0e475943ecbec8112ff2775f2e",
            "input": "Rifampin-induced hypothyroidism without underlying thyroid disease.",
            "output": [
                "Rifampin"
            ]
        },
        {
            "id": "task1447-13140e6b6944425b9223bab01ad03715",
            "input": "A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.",
            "output": [
                "nabumetone"
            ]
        },
        {
            "id": "task1447-ce48066b6ba94a689d54ee3f94ebeb29",
            "input": "Pulmonary fibrosis associated with nabumetone.",
            "output": [
                "nabumetone"
            ]
        },
        {
            "id": "task1447-cd62a5e725224639819200d216ae0f40",
            "input": "Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-dc993fda7cd3429ca1c14f36ab4f0e11",
            "input": "It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.",
            "output": [
                "interferon alpha"
            ]
        },
        {
            "id": "task1447-b702ac605e064f7db4cc7518999d15bd",
            "input": "Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.",
            "output": [
                "clopidogrel"
            ]
        },
        {
            "id": "task1447-5e4d894ac39a42afb2b8db8af6810313",
            "input": "Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.",
            "output": [
                "ATRA"
            ]
        },
        {
            "id": "task1447-287ee6a4b7a9459489001c0ee87314eb",
            "input": "Pulmonary toxicity associated with erlotinib.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-9db0e3188fe548f6be62de6b5014fd63",
            "input": "This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-737802272d9f49afbe8a0a5fe215ca50",
            "input": "We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-8d232d31f7424305932ff28834c3a0ef",
            "input": "It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.",
            "output": [
                "fluoroquinolone"
            ]
        },
        {
            "id": "task1447-134845a0a4ed45819214d959bd9cee9e",
            "input": "Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.",
            "output": [
                "moxifloxacin"
            ]
        },
        {
            "id": "task1447-cb662bdaf7fd4abca71bb1a3daea3e9d",
            "input": "Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-4ccc4d5de9a34590a5dce7028f5d2cac",
            "input": "CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.",
            "output": [
                "desferrioxamine"
            ]
        },
        {
            "id": "task1447-f6ea2756cb2c4ddd9d9b8c99aeabecca",
            "input": "Leflunomide-associated infections in rheumatoid arthritis.",
            "output": [
                "Leflunomide"
            ]
        },
        {
            "id": "task1447-6088f8373b4d411c8df2618c313020db",
            "input": "The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-f8c518b2aacb4c9d94eea05581a3fa0d",
            "input": "This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.",
            "output": [
                "sulfasalazine"
            ]
        },
        {
            "id": "task1447-827bc9eab4744731b1ea5340de7812c2",
            "input": "Uncontrolled headache induced by oxcarbazepine.",
            "output": [
                "oxcarbazepine"
            ]
        },
        {
            "id": "task1447-1b187cb00500469594fb360c2db726e3",
            "input": "CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v. infusion.",
            "output": [
                "dobutamine"
            ]
        },
        {
            "id": "task1447-ab05c7033ef94e9292b73027990efc1a",
            "input": "Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.",
            "output": [
                "dobutamine"
            ]
        },
        {
            "id": "task1447-be8a5ab38e8046ca8d8df1c5be950d0b",
            "input": "PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.",
            "output": [
                "dobutamine"
            ]
        },
        {
            "id": "task1447-8e1cae9320fc47b79b0ca4cd8b9513c4",
            "input": "Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.",
            "output": [
                "efavirenz"
            ]
        },
        {
            "id": "task1447-0d8a5121d61647419e11564b32ca475d",
            "input": "We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.",
            "output": [
                "efavirenz"
            ]
        },
        {
            "id": "task1447-723f8e14400749c6a8f7217101ccdb02",
            "input": "Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.",
            "output": [
                "infliximab"
            ]
        },
        {
            "id": "task1447-354339688a244d59934c972751cadd36",
            "input": "Sustained monomorphic ventricular tachycardia after adenosine infusion.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-728c19677ff94807a4b03e027322f611",
            "input": "We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-b7399a1d79464250962eaba2a7f6016e",
            "input": "Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-43c7852f98464f5f931f0c72dfc776e1",
            "input": "Tardive oculogyric crisis during treatment with clozapine: report of three cases.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-d74ad8c54d4443c891a44bb929141785",
            "input": "Metronidazole neuropathy.",
            "output": [
                "Metronidazole"
            ]
        },
        {
            "id": "task1447-44ca2cb9c44544108ef7d23ccc721098",
            "input": "Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.",
            "output": [
                "metronidazole"
            ]
        },
        {
            "id": "task1447-e5fc68513c2a414f86bd6eb6a5b13406",
            "input": "We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-689f40e9b9ef442e89b46627157db37f",
            "input": "DIAGNOSIS: Sustained ventricular tachycardia possibly owing to thalidomide treatment.",
            "output": [
                "thalidomide"
            ]
        },
        {
            "id": "task1447-3d9776b5dcb24ba6baf68533d7f69f6f",
            "input": "Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.",
            "output": [
                "thalidomide"
            ]
        },
        {
            "id": "task1447-eb8b01554a324249a8583dd976a99d38",
            "input": "A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.",
            "output": [
                "glatiramer acetate"
            ]
        },
        {
            "id": "task1447-a1d70514e39c400798b6ef818f8670d3",
            "input": "Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.",
            "output": [
                "glatiramer acetate"
            ]
        },
        {
            "id": "task1447-055a25f5bc324e81b202252eb2fda20c",
            "input": "This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.",
            "output": [
                "glatiramer acetate"
            ]
        },
        {
            "id": "task1447-fee5b438c3ae4a97b0871a403b07de2c",
            "input": "Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-f3f24a5a6f504d9bb5d8bcd7c06e43fb",
            "input": "Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.",
            "output": [
                "Amiodarone"
            ]
        },
        {
            "id": "task1447-076a41def48e456499e9d65471b61b35",
            "input": "Histopathology of the thyroid in amiodarone-induced hypothyroidism.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-2caa359204524071add9a5dd9ae6ab73",
            "input": "This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-260eae2d59b944feab0269feb7e7e630",
            "input": "Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-d56a871675ed4494b5dc7021d7038970",
            "input": "Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-58aa6bef9f8c49d5bcba518e54a729ad",
            "input": "We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-7c4105c41f1545dc9d98ab2b4962e1be",
            "input": "Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-5a817f9d69cb4a6ea4071f990974c392",
            "input": "We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-a059352a5e024a91b7368375ee32159a",
            "input": "According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-76a42b6397224507b5054f3ea62152d6",
            "input": "CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-d9984fdd088f426aad053b9655632ab3",
            "input": "DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-5b90d52e5d5141dc94d92f1ce67ba5d9",
            "input": "Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-5d55e442544243cca22b93591603a789",
            "input": "Methotrexate-induced papular eruption following treatment of psoriasis.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-e1a136bf50a0451c92388ced6bbde9d7",
            "input": "OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-b8c33123204745b1b0319a62d2cc0a6e",
            "input": "Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-7b7df927a00f4f89bc791c5a5261756b",
            "input": "Metabolic acidosis induced by acetazolamide.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-8948a531cc7a43e59d7432d53f685989",
            "input": "Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.",
            "output": [
                "acetylsalicylic acid"
            ]
        },
        {
            "id": "task1447-ee2e0657f7e2436a99b38d4b00544de4",
            "input": "The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.",
            "output": [
                "acetylsalicylic acid"
            ]
        },
        {
            "id": "task1447-a6051dbdcd3947d08923c7cca117aec8",
            "input": "Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-44f992e25014478497e349ce2ebb6967",
            "input": "This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-ea46498ee48f4f7eba66d6860cea77c9",
            "input": "We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-2567461f630344f1a2413ba3a99feeca",
            "input": "New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-badd56b1a93c46a193bcfe384d38f8ef",
            "input": "Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-3f1fb79e6ed34f1c88952fe7667d4a2d",
            "input": "We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-2380227c56524c249721054a362d0ea7",
            "input": "Severe hepatocellular dysfunction following cyproterone acetate therapy.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-855d6e10662e48c78c55423fd9d4c20f",
            "input": "She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-b0eae2376e454d23828f2b1db4143407",
            "input": "According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-8deb26c23ad74a5b80fac5e1b89e4e6e",
            "input": "Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-7553438c2dae4e79a8c861952fe9bb48",
            "input": "Due to the severity of the rash, temozolomide was permanently discontinued.",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-0cfc5d09cf3b4697bbcb3432ffc38258",
            "input": "Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.",
            "output": [
                "Temozolomide"
            ]
        },
        {
            "id": "task1447-24dc663e2154424c8848150698dc734b",
            "input": "Temozolomide was restarted 2 months later; the patient again developed a fever.",
            "output": [
                "Temozolomide"
            ]
        },
        {
            "id": "task1447-176eb193ff774383a61783afbc7a4986",
            "input": "Exfoliative dermatitis secondary to tobramycin sulfate.",
            "output": [
                "tobramycin sulfate"
            ]
        },
        {
            "id": "task1447-c30093bb21bd4b92b9fc0afe66cc2889",
            "input": "We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.",
            "output": [
                "tobramycin"
            ]
        },
        {
            "id": "task1447-eec0eb98f60b463bbb3b098d0068a42a",
            "input": "Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.",
            "output": [
                "Rituximab-CHOP"
            ]
        },
        {
            "id": "task1447-18393a48f910402bb959112c6bacd955",
            "input": "Phenytoin toxicity: an easily missed cause of cerebellar syndrome.",
            "output": [
                "Phenytoin"
            ]
        },
        {
            "id": "task1447-da2e1b9050f34ff5b373faba3decbc07",
            "input": "A diagnosis of trastuzumab-induced pneumonitis was made.",
            "output": [
                "trastuzumab"
            ]
        },
        {
            "id": "task1447-f9b06af16ec24935ab467927d9b5fece",
            "input": "Life-threatening interstitial lung disease associated with trastuzumab: case report.",
            "output": [
                "trastuzumab"
            ]
        },
        {
            "id": "task1447-21a5d0aedb5d4f74944c8d693e39a746",
            "input": "Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.",
            "output": [
                "4-chloro-7-nitrobenzofurazan"
            ]
        },
        {
            "id": "task1447-bef7c96a7d3142a2b7cb07747d301637",
            "input": "We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-cba90a5b9fd344a4a66820352c206b4c",
            "input": "Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.",
            "output": [
                "leflunomide"
            ]
        },
        {
            "id": "task1447-09e13a26d6b34503a97edb46ae6f637b",
            "input": "Hyponatraemia developed after rechallenge with controlled release carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-6ff0130061ad49ad93eac2d611a5af65",
            "input": "Hyponatraemia during low-dose carbamazepine therapy.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-bfd8361d8863429e8cc882e5eb6dbaa3",
            "input": "We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-afb8c971be5c4d35b5a1e3dd7b3bcc52",
            "input": "In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.",
            "output": [
                "cyclosporine"
            ]
        },
        {
            "id": "task1447-21b31cebb3004100840990bf164a31c4",
            "input": "A short review on imatinib-related hepatotoxicity is also presented.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-e77a91a3d6324f12888f462f892b7709",
            "input": "Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.",
            "output": [
                "Imatinib mesylate"
            ]
        },
        {
            "id": "task1447-5ba61955c8e64cedb46f55de9e3b125f",
            "input": "Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-8674812998734557bbe2f8da7fc8edaf",
            "input": "CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-0e45919b8bc74dde9bac45d6693f414c",
            "input": "OBJECTIVE: To report a case of rapidly occurring hyperglycemia that occurred in a geriatric patient 3 days after treatment with olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-e008db5caf504978a78dfffbf9c84529",
            "input": "Rapidly developing hyperglycemia during treatment with olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-383c9f25dd7948789b2d0db85e7f5dc8",
            "input": "Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-ad1bcccd63a64a6a835f028f3a278023",
            "input": "There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-c0994555869646ec8709c73ba0f3ce13",
            "input": "Bilateral anterior uveitis associated with clomiphene citrate.",
            "output": [
                "clomiphene citrate"
            ]
        },
        {
            "id": "task1447-15dc69256ac846139409a603d04c91f7",
            "input": "PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.",
            "output": [
                "clomiphene citrate"
            ]
        },
        {
            "id": "task1447-ea6c3afc75544e9abfe0a84c27b43a6b",
            "input": "Development of tics in a thirteen-year-old male following atomoxetine use.",
            "output": [
                "atomoxetine"
            ]
        },
        {
            "id": "task1447-1a589d8ae9b34c008e796daf841261c1",
            "input": "There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.",
            "output": [
                "atomoxetine"
            ]
        },
        {
            "id": "task1447-523873955c69412c8e609a28c27d20e2",
            "input": "BACKGROUND: To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally.",
            "output": [
                "ranibizumab"
            ]
        },
        {
            "id": "task1447-d83d8e15476d421f977b78eb90bc16b3",
            "input": "CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.",
            "output": [
                "ranibizumab"
            ]
        },
        {
            "id": "task1447-dbcfb4555c50478fa2dff862e4bf92af",
            "input": "Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.",
            "output": [
                "ranibizumab"
            ]
        },
        {
            "id": "task1447-d92ca518a7e541f8a8339fa74e26f159",
            "input": "Persisent ocular hypertension following intravitreal ranibizumab.",
            "output": [
                "ranibizumab"
            ]
        },
        {
            "id": "task1447-347373538095488d9edc04fea5f4d13a",
            "input": "Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.",
            "output": [
                "efalizumab"
            ]
        },
        {
            "id": "task1447-e94e728b1aa6458392a50c2830efb206",
            "input": "We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.",
            "output": [
                "efalizumab"
            ]
        },
        {
            "id": "task1447-3798582f65f14ce9b59db16734b673ef",
            "input": "Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.",
            "output": [
                "pegaptanib"
            ]
        },
        {
            "id": "task1447-667da8a3217543f19679b6afa902dd5a",
            "input": "The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.",
            "output": [
                "pegaptanib"
            ]
        },
        {
            "id": "task1447-e853187f251f4f3683fcdb9c302fe919",
            "input": "Enalaprilat induced acute parotitis.",
            "output": [
                "Enalaprilat"
            ]
        },
        {
            "id": "task1447-f1d21d5b0d3343c4b14cdc68c3800264",
            "input": "We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.",
            "output": [
                "enalaprilat"
            ]
        },
        {
            "id": "task1447-3dbc425df43b4e429d7704452efd98dc",
            "input": "Severe symptomatic hyponatremia during sibutramine therapy: a case report.",
            "output": [
                "sibutramine"
            ]
        },
        {
            "id": "task1447-d88fa49bf5b04c1096b62802a8bedaea",
            "input": "We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.",
            "output": [
                "sibutramine"
            ]
        },
        {
            "id": "task1447-72f84b4cb7504268b82962dd7c4dfdde",
            "input": "Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.",
            "output": [
                "pregabalin"
            ]
        },
        {
            "id": "task1447-e267909ccc6e4615855513d65e772cac",
            "input": "Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.",
            "output": [
                "Pregabalin"
            ]
        },
        {
            "id": "task1447-cb76ab794eaa47619706d44ce90b1809",
            "input": "We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.",
            "output": [
                "pregabalin"
            ]
        },
        {
            "id": "task1447-4704ac20e708431c9cf291b3dbfa14bf",
            "input": "Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.",
            "output": [
                "Muzolimine"
            ]
        },
        {
            "id": "task1447-8fa5172342e74c4a97279330a0bd23ce",
            "input": "We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.",
            "output": [
                "muzolimine"
            ]
        },
        {
            "id": "task1447-6cc7ac27967b4d28ac5dc9f09362da5e",
            "input": "L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-c52912a71151473caa1f5354867732de",
            "input": "Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.",
            "output": [
                "Anastrozole"
            ]
        },
        {
            "id": "task1447-bd93a3543c8b42afa7ca44444e1f87a3",
            "input": "CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.",
            "output": [
                "Anastrozole"
            ]
        },
        {
            "id": "task1447-7b7f5142650440cbbcf731af6ee07d18",
            "input": "Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.",
            "output": [
                "anastrozole"
            ]
        },
        {
            "id": "task1447-74cd05d1c43a43c4ae9a1b40da9b6ca8",
            "input": "Renal injury due to anastrozole has not been published in the English literature.",
            "output": [
                "anastrozole"
            ]
        },
        {
            "id": "task1447-6cdb8ccdfc9e402eaebfe68fe79a9f35",
            "input": "We believe that the acute renal failure in our patient was associated with anastrozole.",
            "output": [
                "anastrozole"
            ]
        },
        {
            "id": "task1447-c0b78c7282684affbc3b0d23c5a9539f",
            "input": "CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-ec502177990b4860a387e28c582225b1",
            "input": "CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-fbb0917a34264691a47279ec2bd3f84d",
            "input": "Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-894b1753009e48c4b16e3d3df33840ff",
            "input": "Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-c567e3a75c7b495c9eae89e235838936",
            "input": "CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.",
            "output": [
                "baclofen"
            ]
        },
        {
            "id": "task1447-7cd33cb489f342f2b90a1a3456670a24",
            "input": "RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.",
            "output": [
                "baclofen"
            ]
        },
        {
            "id": "task1447-09060d6a79fa466c8c1a7934b6879a9f",
            "input": "Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.",
            "output": [
                "baclofen"
            ]
        },
        {
            "id": "task1447-5dfdd1824333415ca161bcc97081ffbf",
            "input": "Anaphylactic reaction to recombinant insulin-like growth factor-I.",
            "output": [
                "recombinant insulin-like growth factor-I"
            ]
        },
        {
            "id": "task1447-7cac28ca5d70401b9c3197918fe31d0b",
            "input": "We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.",
            "output": [
                "Increlex"
            ]
        },
        {
            "id": "task1447-87370516c27b40909979c056328c9443",
            "input": "Increasing the olanzapine dosage severely aggravated the symptoms of RLS.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-c5d08f6674d0467c8c15e3c823312505",
            "input": "The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-78da0561304747d5aa000167363acbe0",
            "input": "The second patient exhibited sudden PLMS following olanzapine injection.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-9ba23ca83b754ff3b5dfd1a7190fbe26",
            "input": "Nodular scleritis following alendronate therapy.",
            "output": [
                "alendronate"
            ]
        },
        {
            "id": "task1447-5a0d9577fb7d478d856984965b4e3d2e",
            "input": "PURPOSE: To report a case of nodular scleritis following alendronate sodium.",
            "output": [
                "alendronate sodium"
            ]
        },
        {
            "id": "task1447-301461df8a1b40a4b8171c1fb07da95b",
            "input": "Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.",
            "output": [
                "alendronate sodium"
            ]
        },
        {
            "id": "task1447-6ddcb2787e53478fb15f0d678d96e837",
            "input": "In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-20cf66d7efdb4544aa5b572cb9348524",
            "input": "Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.",
            "output": [
                "levofloxacin"
            ]
        },
        {
            "id": "task1447-0e9ecf763fd745e68a396f59d8acb541",
            "input": "Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.",
            "output": [
                "levofloxacin"
            ]
        },
        {
            "id": "task1447-2d2c6b7e214e4992ba8d4b83b789a098",
            "input": "Levofloxacin-induced delirium with psychotic features.",
            "output": [
                "Levofloxacin"
            ]
        },
        {
            "id": "task1447-56457311b411476dba7e9c56ddaee05b",
            "input": "RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.",
            "output": [
                "levofloxacin"
            ]
        },
        {
            "id": "task1447-89de13cce1e04ccfb8b9ee4cbc763854",
            "input": "CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.",
            "output": [
                "Copaxone"
            ]
        },
        {
            "id": "task1447-19f5b0db75b14150ad55455f9d9bb3c6",
            "input": "Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.",
            "output": [
                "copaxone"
            ]
        },
        {
            "id": "task1447-12e5c2b38690431dad41c2a0d4e76f7c",
            "input": "She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.",
            "output": [
                "Copaxone"
            ]
        },
        {
            "id": "task1447-cab45633eb244a3e8ccbd50fd8adbb27",
            "input": "The authors present a case study of a mentally healthy man who repeatedly experienced short-lived, obsessional-like suicidal ideas and images after ingestion of the anti-fungal drug ketoconazole.",
            "output": [
                "ketoconazole"
            ]
        },
        {
            "id": "task1447-28fbb8d1b10e4ef88c75fc4933495fdc",
            "input": "Terlipressin-induced ventricular arrhythmia.",
            "output": [
                "Terlipressin"
            ]
        },
        {
            "id": "task1447-62498f9d70b443fcb1e86f8df6ddc544",
            "input": "Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-c9b0b95747d34e7a9c0165709200c40d",
            "input": "This case describes a 52-year-old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-a2c8b04226b744a5a79b199bcf97ab06",
            "input": "A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy.",
            "output": [
                "VRC"
            ]
        },
        {
            "id": "task1447-391abcf02fe04aaa90d08af27c486db2",
            "input": "Angio-oedema as an unusual tolerable side effect of voriconazole therapy.",
            "output": [
                "voriconazole"
            ]
        },
        {
            "id": "task1447-e18e2f8b1a674447b4ea39ac482a66a4",
            "input": "Here, we report a case of angio-oedema associated with VRC therapy.",
            "output": [
                "VRC"
            ]
        },
        {
            "id": "task1447-c5a41d8216864b33a9d95e8660d3a84e",
            "input": "To our knowledge, this is the first report of an angio-oedema associated with VRC.",
            "output": [
                "VRC"
            ]
        },
        {
            "id": "task1447-c1f11e9ab16f4e7988eb38f64d1f517e",
            "input": "Multiple seizures after bupropion overdose in a small child.",
            "output": [
                "bupropion"
            ]
        },
        {
            "id": "task1447-061ed9ec27e94056b160dd1f5cb2097c",
            "input": "We report a case of pediatric bupropion ingestion resulting in multiple seizures.",
            "output": [
                "bupropion"
            ]
        },
        {
            "id": "task1447-9c649ae4d07048428cb8f2a9c6fb5156",
            "input": "Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.",
            "output": [
                "Methylphenidate"
            ]
        },
        {
            "id": "task1447-b77761b28b124586a05251dc1096d34e",
            "input": "This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.",
            "output": [
                "methylphenidate"
            ]
        },
        {
            "id": "task1447-1795dd832a334b808d27745e4dc7c17a",
            "input": "Cephalosporin-induced leukopenia following rechallenge with cefoxitin.",
            "output": [
                "Cephalosporin"
            ]
        },
        {
            "id": "task1447-53f8e3ca436840c9ab835f362c95ca3b",
            "input": "CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.",
            "output": [
                "Cefazolin"
            ]
        },
        {
            "id": "task1447-3c3b9ba920d44f44b75966b8c86b66e9",
            "input": "OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.",
            "output": [
                "cefazolin"
            ]
        },
        {
            "id": "task1447-3b45a436e4024a8e9f0f528b030c4ea2",
            "input": "Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable.",
            "output": [
                "cephalosporin"
            ]
        },
        {
            "id": "task1447-4f14f612f3f445afad13764ddc75485d",
            "input": "Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-fce0c4d32a5a4ba19c01331acaef9b7d",
            "input": "This therapy was also complicated by Warfarin-induced skin necrosis.",
            "output": [
                "Warfarin"
            ]
        },
        {
            "id": "task1447-2922468b4c9d44428464eada2b011234",
            "input": "The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-1898f6defc1442098fff88f8d3c02793",
            "input": "CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.",
            "output": [
                "propafenone"
            ]
        },
        {
            "id": "task1447-1124216db21247b980652f6e99fb3a2f",
            "input": "CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-50d4397368704015b8f89066f923b1ad",
            "input": "Based on the Naranjo algorithm, the adverse reaction observed was probably related to the hydroxyurea treatment (score = 6); however, the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-3663b1d526434197a8015bf692310f77",
            "input": "It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-7bebee684bdd41788eaf0cde491d12c4",
            "input": "Disseminated salmonellosis in a patient treated with temozolomide.",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-60c8d79cdb9e403fa05f3928f2d5083c",
            "input": "We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.",
            "output": [
                "temozolomide"
            ]
        },
        {
            "id": "task1447-761f399d1b224b00bf1335a990e8add4",
            "input": "Ceftriaxone-induced fixed drug eruption: first report.",
            "output": [
                "Ceftriaxone"
            ]
        },
        {
            "id": "task1447-1285f43b739f4d108ae0822a83cbea65",
            "input": "We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.",
            "output": [
                "ceftriaxone"
            ]
        },
        {
            "id": "task1447-7ede7ff40a1f4c5792da19025dec408f",
            "input": "CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.",
            "output": [
                "gabapentin"
            ]
        },
        {
            "id": "task1447-e39faaaa12a042769ea86d3e28d08699",
            "input": "Gabapentin toxicity in renal failure: the importance of dose adjustment.",
            "output": [
                "Gabapentin"
            ]
        },
        {
            "id": "task1447-5680c8fbef1b45918f71f9d91207b540",
            "input": "OBJECTIVE: This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure.",
            "output": [
                "gabapentin"
            ]
        },
        {
            "id": "task1447-c5d0dc0db6c84eceab8f61335719148b",
            "input": "Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection.",
            "output": [
                "triamcinolone acetonide"
            ]
        },
        {
            "id": "task1447-d768e273d6df42e9914f57112eb5326f",
            "input": "CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.",
            "output": [
                "IVTA"
            ]
        },
        {
            "id": "task1447-7fc60c56158245028ed797ddda136e09",
            "input": "RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.",
            "output": [
                "IVTA"
            ]
        },
        {
            "id": "task1447-f86631ec3cbf456686c6e0cc4d6a904e",
            "input": "Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-2122801e88f84d07bb3451af1bd9f799",
            "input": "Hemorrhage from a falx meningioma after internal use of low-dose aspirin.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-b8d030a2b8c14468bc4b51eea4f7be7a",
            "input": "On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-dce073b2696846b9a628d2f802912f0d",
            "input": "Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-cd48654fc8c24e78aac353b9d0004bb5",
            "input": "We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-fccebb248b0943939ec0609d2359e1f5",
            "input": "Acute coronary syndromes can be associated with the infusion of rituximab.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-2de3bfecb8b44a9db2e41a0f63fee7a7",
            "input": "Acute coronary syndromes complicating the first infusion of rituximab.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-00d4411aa1a94a38869dc68f6a7a214a",
            "input": "The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-b09c19076a6c4648aa6fb63912a72618",
            "input": "The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-bf853dd0896940a09e4206369231a648",
            "input": "We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.",
            "output": [
                "rituximab"
            ]
        },
        {
            "id": "task1447-9da48d518c7f47a5a9befd41bc4527e4",
            "input": "Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-44593679d2714121a9520cd398a81eb7",
            "input": "CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-351af8c1f3e84cbbbe38fcfd38555cac",
            "input": "High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-15279720ee2b47f78952a634eee6117a",
            "input": "When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.",
            "output": [
                "DSCG"
            ]
        },
        {
            "id": "task1447-1d8a5c2101e940a5af7120752ab8e222",
            "input": "Syncope induced by propranolol in hypertrophic cardiomyopathy.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-3845679d670e430f86c7cbc91625c645",
            "input": "Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.",
            "output": [
                "Leflunomide"
            ]
        },
        {
            "id": "task1447-8c1b1bb03c724bceb288597cd7da1994",
            "input": "Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-0ed5b87c16534d3b88022ac48d73f49f",
            "input": "This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.",
            "output": [
                "oxcarbazepine"
            ]
        },
        {
            "id": "task1447-626fb74b0e7d4a7c9ad45f84cb8c2316",
            "input": "After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.",
            "output": [
                "Partusisten"
            ]
        },
        {
            "id": "task1447-8bea5ac9ba34443c9f2308153511c751",
            "input": "Rosaceiform eruption induced by erlotinib.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-d8027191f63440358b2cb5e66434bc50",
            "input": "The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-3390a9a0d24d4bb09be96758fae62278",
            "input": "In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-5c0240c5ea0c4e8d8bb694aaa86685b4",
            "input": "Management and successful desensitization in methotrexate-induced anaphylaxis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-4063decf141d4fa58f651326ad084b18",
            "input": "Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-2b4bca11cd2e436284b6bccb0da827e3",
            "input": "We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-7d694283d28b4828a140f94a10f7dd4f",
            "input": "Drug-induced fever due to diltiazem.",
            "output": [
                "diltiazem"
            ]
        },
        {
            "id": "task1447-372f48d6473b4941b13ce202a04951ff",
            "input": "Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.",
            "output": [
                "diltiazem"
            ]
        },
        {
            "id": "task1447-6a91f8a30b534e08986067d425348f04",
            "input": "To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.",
            "output": [
                "diltiazem hydrochloride"
            ]
        },
        {
            "id": "task1447-db15a8ffbdc04cb3b04c2c1bfa801743",
            "input": "A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.",
            "output": [
                "Adriamycin"
            ]
        },
        {
            "id": "task1447-a68a984bc1264fe1a3960c61caa9ef19",
            "input": "Radiologic recognition of adriamycin cardiotoxicity.",
            "output": [
                "adriamycin"
            ]
        },
        {
            "id": "task1447-b03702d491d74651bc5353a73dcbea34",
            "input": "The role of Adriamycin in the production of cardiotoxicity is reviewed.",
            "output": [
                "Adriamycin"
            ]
        },
        {
            "id": "task1447-6b2373d90a834337922452df6387b1ed",
            "input": "Carbamazepine-induced Diabetes mellitus.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-632ec5ea48e14fc583aff4688a54ee3b",
            "input": "Diabetes Mellitus was observed in a patient given carbamazepine.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-1cbb93f99f67427fab40fb7a4fc55d38",
            "input": "Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-446fd5a56e1e478d8ef777d04df5bc7d",
            "input": "Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-f35b10f7550d45859e489459db67dfb8",
            "input": "Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-01b612db631b4b5da937b2ddef759e72",
            "input": "Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-a75ed73aac74405899f525a83544b925",
            "input": "Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis.",
            "output": [
                "posaconazole"
            ]
        },
        {
            "id": "task1447-1674c3b35d464fceb22b333ef01ad032",
            "input": "Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.",
            "output": [
                "triamcinolone"
            ]
        },
        {
            "id": "task1447-f9895e8609364b0c9fc4d1c9756c197e",
            "input": "We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.",
            "output": [
                "triamcinolone"
            ]
        },
        {
            "id": "task1447-bea8284cb7224c0da67cab8ec034136c",
            "input": "A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.",
            "output": [
                "flunitrazepam"
            ]
        },
        {
            "id": "task1447-2cd52b6568d1404a9885b78ea71efd7a",
            "input": "Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.",
            "output": [
                "flunitrazepam"
            ]
        },
        {
            "id": "task1447-d504d8a59aa141839ce4a5193e0d1cc5",
            "input": "A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.",
            "output": [
                "lenalidomide"
            ]
        },
        {
            "id": "task1447-7bfc2a3786d14871b7f217f0823a3d9a",
            "input": "Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.",
            "output": [
                "lenalidomide"
            ]
        },
        {
            "id": "task1447-5b3884615b55477fa8474a22b3dc6fc4",
            "input": "After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-b2a20d3a4ab34c2ba05191cc98a14b7b",
            "input": "CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.",
            "output": [
                "Amantadine"
            ]
        },
        {
            "id": "task1447-829d0b6a80b24f7c807cae86dfee6555",
            "input": "Corneal edema recurred when the administration of amantadine was resumed.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-9743e23feb8a44b585df0d3f91b7f37d",
            "input": "Corneal endothelial dysfunction associated with amantadine toxicity.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-fd8e09d8f3ec424890ebaf7d9d3045ba",
            "input": "PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-ac3aa94bed624affb4b1bfd03a86e727",
            "input": "RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-db461f46ba4b46fab03ad9bff6b8ac8d",
            "input": "Therefore, amantadine was permanently discontinued and the cornea cleared again.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-5eb0ef258600477a90c35a115e51a9ea",
            "input": "Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?",
            "output": [
                "sunitinib"
            ]
        },
        {
            "id": "task1447-4d327e96a75b41c1bdde15026eab3858",
            "input": "We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.",
            "output": [
                "Sunitinib"
            ]
        },
        {
            "id": "task1447-eda3e6f7946c4dd6a4dc060d5a4f284b",
            "input": "Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-3deb44cb723b4bf8829fed09ffe8a60c",
            "input": "This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-4e017bfd87284054b32af489da04df63",
            "input": "A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-65a3edfa0ac44d8384d330027f704615",
            "input": "Methotrexate induced sprue-like syndrome.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-d13338e16170468fbd7be907c9582c2e",
            "input": "Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-de416ce8aad64c02a5ff6f2c041d23f6",
            "input": "We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-0cc1490531eb4c7eaf79ab682c72d3dc",
            "input": "IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.",
            "output": [
                "IFNalpha"
            ]
        },
        {
            "id": "task1447-3e5de9a5468548bb8190ebd5f8787222",
            "input": "We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.",
            "output": [
                "IFN-alpha"
            ]
        },
        {
            "id": "task1447-9fd094f62bf44c4eb4c385a9506cd475",
            "input": "Interstitial granulomatous dermatitis associated with darifenacin.",
            "output": [
                "darifenacin"
            ]
        },
        {
            "id": "task1447-a9efad5e71f04cdca903ccedd6963ce3",
            "input": "The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.",
            "output": [
                "darifenacin"
            ]
        },
        {
            "id": "task1447-7b623eb102fd443cbd8512671a42419a",
            "input": "METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-30d5f3451d544bba89c72ff0f2296fbb",
            "input": "Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-6e67a9be12654b03a59c24195a8dd3b1",
            "input": "Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-0d9c9e6f411b4c2a800a43d16c152fad",
            "input": "We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-d6e26c60481b4cac9fce9b9b5ed4239e",
            "input": "Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-632edbca22664ec28994425ea7c74ecb",
            "input": "Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-6009f608d3ce43b1b04ef739739dd894",
            "input": "Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-6c5364549e374074a97003da21ad4e0d",
            "input": "Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.",
            "output": [
                "Tenofovir"
            ]
        },
        {
            "id": "task1447-c5bf8782d8994df8b23baa87079638d3",
            "input": "In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.",
            "output": [
                "piroxicam"
            ]
        },
        {
            "id": "task1447-373d6a3772734b6b90030832c51f41de",
            "input": "Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.",
            "output": [
                "immunoglobulin"
            ]
        },
        {
            "id": "task1447-1ee38b6f7be14aeea508773f58bd381c",
            "input": "Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).",
            "output": [
                "immunoglobulin"
            ]
        },
        {
            "id": "task1447-613d704dcae7425a8cdef16cd331e184",
            "input": "The exact mechanism of IVIG-associated acute renal failure remains unclear.",
            "output": [
                "IVIG"
            ]
        },
        {
            "id": "task1447-bad95060d78f433ba1ecc635cd1e9093",
            "input": "A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.",
            "output": [
                "temsirolimus"
            ]
        },
        {
            "id": "task1447-440e0e1e3c964c6991432f1be3aa2eed",
            "input": "Temsirolimus-induced glomerulopathy.",
            "output": [
                "Temsirolimus"
            ]
        },
        {
            "id": "task1447-73196291d562435fb5b5e4462df12439",
            "input": "Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-ab7e346f4a45455781f2eaec6fbd6506",
            "input": "We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-a6ca2d771f9642af9199a9128bfc25e1",
            "input": "Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.",
            "output": [
                "Bisphosphonate"
            ]
        },
        {
            "id": "task1447-fe05d7dac49c46a48222c7ada06ecfcb",
            "input": "Bisphosphonate-related osteonecrosis of the skull base.",
            "output": [
                "Bisphosphonate"
            ]
        },
        {
            "id": "task1447-0ce660097ab24c9c9b922e4b3c6d6b7b",
            "input": "A previous study of patients with \"quinine-associated TTP/HUS\" found that ADAMTS13 activities were not abnormal in 12/12 patients.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-ce813c53d4b546248fa336e4c2ba528e",
            "input": "We recommend that a TMA in association with quinine be consistently referred to as quinine-associated thrombotic microangiopathy (quinine-TMA) to better distinguish this entity from idiopathic TTP.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-3f981216be504c93a51ee10b89bd93da",
            "input": "Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.",
            "output": [
                "epirubicin"
            ]
        },
        {
            "id": "task1447-4f21b2466e6e47bdbca2b1f883546c11",
            "input": "MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.",
            "output": [
                "epirubicin"
            ]
        },
        {
            "id": "task1447-dc46d7fe18014351b57309145cade2e5",
            "input": "Aliskiren-associated acute renal failure with hyperkalemia.",
            "output": [
                "Aliskiren"
            ]
        },
        {
            "id": "task1447-de54fdd278044d4a8438281895d0a060",
            "input": "According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-1e0192f04ddd43ffbc55833ae1388520",
            "input": "CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-538b4c2ef60442a0bae34c3c41de4d22",
            "input": "Probable enoxaparin-induced hepatotoxicity.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-60edf0ad5def4febb9255b41a4d24657",
            "input": "PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-c7786187fac845e5a1c78b7d47897a61",
            "input": "Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-f58c65b16a974d69916daafbbb7150d2",
            "input": "The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-b5bc937cf449466a8a8075cc921dda59",
            "input": "We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-479e7037be1440b1acb569392c90b568",
            "input": "Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.",
            "output": [
                "Cyclosporine"
            ]
        },
        {
            "id": "task1447-62ed582aba2e4bbaa7f6b576abbc2bdb",
            "input": "In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.",
            "output": [
                "cyclosporine"
            ]
        },
        {
            "id": "task1447-271dd717f0db407d9e65f145b825193f",
            "input": "OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).",
            "output": [
                "calcineurin"
            ]
        },
        {
            "id": "task1447-23e02d7ca7c046e395eb6f24353344cf",
            "input": "Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-6227859057134ab390a0c684cd1a79ea",
            "input": "This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.",
            "output": [
                "risperidone"
            ]
        },
        {
            "id": "task1447-b0f269a7fffa4c47914c0b394c948f1a",
            "input": "The most common complication of warfarin use is adverse bleeding.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-526529640a2946c098d1e2fc5eb29ca4",
            "input": "DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.",
            "output": [
                "zidovudine"
            ]
        },
        {
            "id": "task1447-dcb5912907734f4e8abaf368f6893734",
            "input": "INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.",
            "output": [
                "stavudine"
            ]
        },
        {
            "id": "task1447-3c5093fc61a6421b880503e0b87ae781",
            "input": "Anaphylactic reaction to bacitracin ointment.",
            "output": [
                "bacitracin"
            ]
        },
        {
            "id": "task1447-bcfceed5b5a645a0918bcc19fe1b0bb5",
            "input": "We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.",
            "output": [
                "bacitracin"
            ]
        },
        {
            "id": "task1447-92779c0a57454a6f8895d5ce8ca58517",
            "input": "Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-012703c3c78c4dec8fcc97c2d241966b",
            "input": "Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.",
            "output": [
                "somatostatin"
            ]
        },
        {
            "id": "task1447-0a300e663b654820bcd377db8c224793",
            "input": "In these patients, long-acting octreotide may trigger serious hypoglycemia.",
            "output": [
                "octreotide"
            ]
        },
        {
            "id": "task1447-3f81a0e8f48f475ab5db2d070d9007db",
            "input": "Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-147301bfd8e6492192d1a25a50da34a7",
            "input": "The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.",
            "output": [
                "AZA"
            ]
        },
        {
            "id": "task1447-7af115a70e024987a11fc759ddf9a0d8",
            "input": "We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.",
            "output": [
                "AZA"
            ]
        },
        {
            "id": "task1447-fed8bb26e2544a25b2d6cb3ba028ceff",
            "input": "Isoniazid causing breast tissue enlargement has been very rarely reported.",
            "output": [
                "Isoniazid"
            ]
        },
        {
            "id": "task1447-b4993b9d89694b68bba3995069d6f867",
            "input": "Isoniazid induced gynaecomastia: a case report.",
            "output": [
                "Isoniazid"
            ]
        },
        {
            "id": "task1447-8b28f751f8ed4d5ea42a0adcadeb824e",
            "input": "Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.",
            "output": [
                "alemtuzumab"
            ]
        },
        {
            "id": "task1447-ac70dd92a0584ceb9537e2d49502f91c",
            "input": "Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-81bf2af3efa54d2cadd6dabd4ab007fc",
            "input": "The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-3be7e3243e7743a1a70a93922b09e01d",
            "input": "Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.",
            "output": [
                "tranexamic acid"
            ]
        },
        {
            "id": "task1447-96909cdcd5c240ccb34c059f5e496adf",
            "input": "Rhabdomyolysis following clarithromycin monotherapy.",
            "output": [
                "clarithromycin"
            ]
        },
        {
            "id": "task1447-f8336e300f304d9e8945ebe6d967fd34",
            "input": "We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications.",
            "output": [
                "clarithromycin"
            ]
        },
        {
            "id": "task1447-4d950ed201224c8db5934ac6984852f4",
            "input": "However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again.",
            "output": [
                "sunitinib"
            ]
        },
        {
            "id": "task1447-a5573eafc652490c835902ee726a486c",
            "input": "Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.",
            "output": [
                "sunitinib"
            ]
        },
        {
            "id": "task1447-1c27c1840b974155a00d3e2f116e0053",
            "input": "The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors.",
            "output": [
                "sunitinib"
            ]
        },
        {
            "id": "task1447-4659ae8bf6074772bc233e18fd08cb06",
            "input": "Divalproex sodium-induced eosinophilic pleural effusion.",
            "output": [
                "Divalproex sodium"
            ]
        },
        {
            "id": "task1447-3882ba8f07674be9ab72eeed88936ad8",
            "input": "Withdrawal of Depakote resulted in resolution of the effusion.",
            "output": [
                "Depakote"
            ]
        },
        {
            "id": "task1447-eb124b190ba1427cb4ea9400c3084e73",
            "input": "Flurbiprofen-associated acute tubulointerstitial nephritis.",
            "output": [
                "Flurbiprofen"
            ]
        },
        {
            "id": "task1447-b3aa79ffe76a447dafd94fcabb7218f4",
            "input": "We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.",
            "output": [
                "flurbiprofen"
            ]
        },
        {
            "id": "task1447-eab93b61f46c4a97873a3d3cb5f1b82c",
            "input": "Stupor and fast activity on electroencephalography in a child treated with valproate.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-c5655488d27e4601b68760395061f053",
            "input": "The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-d431bfa4f365421c8cfaa7adce4e4132",
            "input": "This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.",
            "output": [
                "sorafenib"
            ]
        },
        {
            "id": "task1447-9846d1a01013419ba31cae469de2b890",
            "input": "According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.",
            "output": [
                "tigecycline"
            ]
        },
        {
            "id": "task1447-c2ded5a9173c4553a1af9ee75d525bcf",
            "input": "Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.",
            "output": [
                "tigecycline"
            ]
        },
        {
            "id": "task1447-46dd381a16174eacae1f34441ca35a4e",
            "input": "Tigecycline-induced acute pancreatitis: case report and literature review.",
            "output": [
                "Tigecycline"
            ]
        },
        {
            "id": "task1447-b35d161b7ce046349d0e7ccbc5af5a64",
            "input": "We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.",
            "output": [
                "leuprolide acetate"
            ]
        },
        {
            "id": "task1447-6b3072fbb16f4d669d75ac1513dda902",
            "input": "Aripiprazole-induced hiccups: a case report.",
            "output": [
                "Aripiprazole"
            ]
        },
        {
            "id": "task1447-e0e2f18d4954436faf18a9db4119e4c1",
            "input": "We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.",
            "output": [
                "aripiprazole"
            ]
        },
        {
            "id": "task1447-9bc0b2b7786f4dd691a1db98848998f5",
            "input": "CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.",
            "output": [
                "sertraline"
            ]
        },
        {
            "id": "task1447-4f0423a3bd0d4ef6bd86d594955d163f",
            "input": "DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.",
            "output": [
                "sertraline"
            ]
        },
        {
            "id": "task1447-4bccafa9807c4bc4ad6b3f456845f4d1",
            "input": "OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.",
            "output": [
                "sertraline"
            ]
        },
        {
            "id": "task1447-dd2a1f4eb56d4dd6aead0458e41c9202",
            "input": "Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.",
            "output": [
                "Sertraline"
            ]
        },
        {
            "id": "task1447-00acfbfb11bc47cd8ebd6c2bd25506ee",
            "input": "The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.",
            "output": [
                "sertraline"
            ]
        },
        {
            "id": "task1447-2dc60acd38374a938e8839f8af856537",
            "input": "Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-393e1ed1e12c481fa658d2cc8be238fe",
            "input": "He had priapism following the use of olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-bf9299aeb11d4096a6e7028f238842fb",
            "input": "Priapism associated with olanzapine.",
            "output": [
                "olanzapine"
            ]
        },
        {
            "id": "task1447-cd44a354e969479fa4cf03a285c535b2",
            "input": "Can ketamine prescribed for pain cause damage to the urinary tract?",
            "output": [
                "ketamine"
            ]
        },
        {
            "id": "task1447-9f953cbdb19b48ce950494c18fde997a",
            "input": "Possible mechanisms for damage to the urothelium by ketamine are suggested.",
            "output": [
                "ketamine"
            ]
        },
        {
            "id": "task1447-3bea6868e34e4e44a9d815f52abf57d7",
            "input": "Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.",
            "output": [
                "ketamine"
            ]
        },
        {
            "id": "task1447-536c6f7d7f5040e98ce261bca2167be2",
            "input": "Carbamazepine-induced hyperammonemia.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-ab78368a4ac940a587c8ca15efc7e83e",
            "input": "CONCLUSION: A 26-year-old man with bipolar disorder developed hyperammonemia three weeks after initiating carbamazepine therapy.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-4c122c519c1e4b04b09b3d448752260e",
            "input": "He had also developed elevated serum ammonia levels while on valproic acid.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-6d49d7132ebe4b77ac6129fbfa8708be",
            "input": "PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-7f65c78a51b94dda8410a8e364eff9e4",
            "input": "A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.",
            "output": [
                "adalimumab"
            ]
        },
        {
            "id": "task1447-61f90de95eb6460d9dce5f44c0ecef8d",
            "input": "Acute bilateral phrenic neuropathy following treatment with adalimumab.",
            "output": [
                "adalimumab"
            ]
        },
        {
            "id": "task1447-49c583e507454680ba440aa5625665a9",
            "input": "CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.",
            "output": [
                "LMWH"
            ]
        },
        {
            "id": "task1447-ee76cc2722134f28bd7c03c41b6e25b1",
            "input": "On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.",
            "output": [
                "dalteparin"
            ]
        },
        {
            "id": "task1447-c76f204ea8a4455ab683979dafe2cb59",
            "input": "Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-de3eb4d44d6043fcbfad59886a0158ca",
            "input": "Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-90f302d6dc8e4b8c8507f86081101670",
            "input": "Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.",
            "output": [
                "bevacizumab"
            ]
        },
        {
            "id": "task1447-97862b2ce27941ec9e15f2ea7e5c5586",
            "input": "Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-e0a10957d638410390c3c5cd824d8f0e",
            "input": "Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-6e5911ef572948368cdd33617e6fa71e",
            "input": "To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-24da60e59e4a46859ebcf4539770d3a0",
            "input": "Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.",
            "output": [
                "Sorafenib"
            ]
        },
        {
            "id": "task1447-166c9c0f37834c9ba92d11c465300ef7",
            "input": "Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.",
            "output": [
                "oxymetazoline"
            ]
        },
        {
            "id": "task1447-db46880f600b4242b9bd6884d8a1d5f5",
            "input": "We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.",
            "output": [
                "oxymetalzoline"
            ]
        },
        {
            "id": "task1447-35cb45de0edd4025b875431607d047db",
            "input": "Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-19aef9f9e2184563bd123cd12cdc3f73",
            "input": "Nitrofurantoin-induced acute liver damage in pregnancy.",
            "output": [
                "Nitrofurantoin"
            ]
        },
        {
            "id": "task1447-3cfcb92ffd124e728060fbababec4e07",
            "input": "Primary central nervous system lymphoma in a patient treated with natalizumab.",
            "output": [
                "natalizumab"
            ]
        },
        {
            "id": "task1447-fdf9cb81ef4e4f38b0bb226a0cd92ba2",
            "input": "OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-eabe065eb30b44e98055dc2ad1a4dc12",
            "input": "Severe apnea in an infant exposed to lamotrigine in breast milk.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-ab7891262c134a86b0fc5a61b2a3db0c",
            "input": "The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.",
            "output": [
                "lamotrigine"
            ]
        },
        {
            "id": "task1447-f07c9a53d08146699da99c5f3bfc17bc",
            "input": "Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.",
            "output": [
                "dasatinib"
            ]
        },
        {
            "id": "task1447-8fb06700124743388b37de9fc3d6c0da",
            "input": "Dasatinib-induced pleural effusions: a lymphatic network disorder?",
            "output": [
                "Dasatinib"
            ]
        },
        {
            "id": "task1447-258f4f512b2f47acaf9394847bcfe120",
            "input": "RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-bcec8c8372eb4555849e5708504628f0",
            "input": "One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.",
            "output": [
                "adalimumab"
            ]
        },
        {
            "id": "task1447-1a41a2bb521a46eeae609655f6de63fe",
            "input": "Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.",
            "output": [
                "adalimumab"
            ]
        },
        {
            "id": "task1447-4ba29f0574e04a6689443ea99eac2e4d",
            "input": "Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.",
            "output": [
                "Amikacin"
            ]
        },
        {
            "id": "task1447-8deaf5bb6a2a47528cd5461c3ddbfc62",
            "input": "Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.",
            "output": [
                "Thrombin"
            ]
        },
        {
            "id": "task1447-b95be77c29174e4b8891659ee08f8e3d",
            "input": "Ciprofloxacin-induced hemorrhagic vasculitis.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-ce640b4d79994ceebca6a2c177b9a787",
            "input": "Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-d8851157b3e843d9a20bdbb41642134a",
            "input": "Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-a0bb4ecf5b0d465187f3aced779f240d",
            "input": "However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.",
            "output": [
                "sorafenib"
            ]
        },
        {
            "id": "task1447-7a795cacde7c462ea2ef848fa7468e0e",
            "input": "Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.",
            "output": [
                "sorafenib"
            ]
        },
        {
            "id": "task1447-711782d3a16b4825b5238aaf3429e9ff",
            "input": "In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.",
            "output": [
                "sorafenib"
            ]
        },
        {
            "id": "task1447-7f22912bbc9a408291540887933879cc",
            "input": "Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.",
            "output": [
                "sorafenib"
            ]
        },
        {
            "id": "task1447-3c6bd6a28a764dc6a296f6a6a99e1b1e",
            "input": "Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-dddf6f4f824946c4a99454bb10188d6e",
            "input": "Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.",
            "output": [
                "Gemcitabine"
            ]
        },
        {
            "id": "task1447-bb89f02e15684c15845ac774bd9cb622",
            "input": "In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.",
            "output": [
                "gemcitabine"
            ]
        },
        {
            "id": "task1447-6d61954a3766455ca1d1d147a9baccb6",
            "input": "He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.",
            "output": [
                "licorice"
            ]
        },
        {
            "id": "task1447-27b5fd2fd2964c908beab17411bc8b31",
            "input": "Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA-treated areas.",
            "output": [
                "8MOP"
            ]
        },
        {
            "id": "task1447-00f1e02766a74bae82861b79945f025b",
            "input": "Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-2da10965d2964e4891acffa152b248ed",
            "input": "We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-c3d906a798254b0cbcb8cd9ad7763fb4",
            "input": "Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.",
            "output": [
                "Clozapine"
            ]
        },
        {
            "id": "task1447-8833d3f8a9024dbdbcda82e0262f4336",
            "input": "However, several case reports have suggested that clozapine could also cause TD.",
            "output": [
                "clozapine"
            ]
        },
        {
            "id": "task1447-ea9dd7a90a27495ba73c4b3d1827ca32",
            "input": "OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).",
            "output": [
                "Clozapine"
            ]
        },
        {
            "id": "task1447-885127a2f7914f699bda369741ce1301",
            "input": "Administration of cisplatin in three patients with carboplatin hypersensitivity: is skin testing useful?",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-73bfd1ba07b045e193f5ccc2aa72ac9d",
            "input": "Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-6dac09d7ea4b440582bdf73b892cd953",
            "input": "Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.",
            "output": [
                "carboplatin"
            ]
        },
        {
            "id": "task1447-172d49c6297b42d48cb1185668ffc329",
            "input": "A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.",
            "output": [
                "ritodrine"
            ]
        },
        {
            "id": "task1447-29f1a5b569e244ac86e63fbe16e9f415",
            "input": "Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.",
            "output": [
                "anthracycline"
            ]
        },
        {
            "id": "task1447-39d6e11f531e406b88b318582958d417",
            "input": "CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-b5a7f3c8a50f41bc8ed98a4855e2433e",
            "input": "Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.",
            "output": [
                "imatinib mesylate"
            ]
        },
        {
            "id": "task1447-fa32ade8e0a6455a99302c2b4f219be2",
            "input": "OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.",
            "output": [
                "imatinib"
            ]
        },
        {
            "id": "task1447-d4737a1383964c5e9cdfa32d6ab14e0a",
            "input": "Interferon-based treatments have the potential to decrease the burden of disease, but are complicated by side effects, including neuropsychiatric symptoms.",
            "output": [
                "Interferon"
            ]
        },
        {
            "id": "task1447-050f34aee071417dae5ee70155843144",
            "input": "Interferon-induced psychosis as a \"psychiatric contraindication\" to hepatitis C treatment: a review and case-based discussion.",
            "output": [
                "Interferon"
            ]
        },
        {
            "id": "task1447-53a1010389214e26a60c9a839737bc0b",
            "input": "OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.",
            "output": [
                "interferon"
            ]
        },
        {
            "id": "task1447-c3184e2971fd448cb439b6360364a9cb",
            "input": "CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.",
            "output": [
                "Zidovudine"
            ]
        },
        {
            "id": "task1447-266b7b7d5723475397699af63c959e84",
            "input": "Zidovudine induced pure red cell aplasia: a case report.",
            "output": [
                "Zidovudine"
            ]
        },
        {
            "id": "task1447-7458c53bdcbb484abca4ff91cdf03bb7",
            "input": "PURPOSE: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity.",
            "output": [
                "hydroxychloroquine"
            ]
        },
        {
            "id": "task1447-3826d35ed46a45f7860c85006171ab23",
            "input": "Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.",
            "output": [
                "hydroxychloroquine"
            ]
        },
        {
            "id": "task1447-607d259db5404f849109518f5d31a3a8",
            "input": "Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-c7c6921f30904566b00a0515f90ade2e",
            "input": "Trazodone-induced transient hypomanic symptoms and their management.",
            "output": [
                "Trazodone"
            ]
        },
        {
            "id": "task1447-b539ddade33c4a23b2e4938eadf805e5",
            "input": "Introduction of etanercept was also clinically effective but followed by development of severe heart failure.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-fe653f416f4c41f99de47ffd029156da",
            "input": "Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.",
            "output": [
                "etanercept"
            ]
        },
        {
            "id": "task1447-b5dfaae923e34f1ab2014d3fbd79839d",
            "input": "Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.",
            "output": [
                "methylephedrine"
            ]
        },
        {
            "id": "task1447-c82d154e39614f84b811e99a60028a28",
            "input": "A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-6b4ceda99cb249e2b798c7160bbd77df",
            "input": "Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-eadc0e75523947e3b54f6399470a2606",
            "input": "We report here a rare case of pleuropericarditis due to methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-e12f16e40b1642dea1902fbf0070a8fb",
            "input": "Tremor: a newly described adverse event with long-term itraconazole therapy.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-95a061bc8e7b48c4b956dbbd1ca437c3",
            "input": "Hypersensitivity to zonisamide was confirmed by the skin patch test.",
            "output": [
                "zonisamide"
            ]
        },
        {
            "id": "task1447-879a32be01d24419baed217be33b2a48",
            "input": "Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.",
            "output": [
                "bisabolol"
            ]
        },
        {
            "id": "task1447-1cd18d5e53ec4d7ca51f0f97575363c8",
            "input": "Case report: acute renal failure after administering intravenous immunoglobulin.",
            "output": [
                "immunoglobulin"
            ]
        },
        {
            "id": "task1447-b90f2a7b2adc47638b8752de7bb02ac4",
            "input": "The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.",
            "output": [
                "IVIG"
            ]
        },
        {
            "id": "task1447-773b85e7aa1840af8df5fd67b2416ac3",
            "input": "Severe vancomycin-induced anaphylactic reaction.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-6da82c5c948e46798996be71aaacc18c",
            "input": "We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.",
            "output": [
                "vancomycin"
            ]
        },
        {
            "id": "task1447-c21a02dd842f486a900f2d4b32ef5115",
            "input": "Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.",
            "output": [
                "hexoprenaline"
            ]
        },
        {
            "id": "task1447-49ba47fe83da41b0926c7d333558a92a",
            "input": "Pulmonary oedema after hexoprenaline administration in preterm labour.",
            "output": [
                "hexoprenaline"
            ]
        },
        {
            "id": "task1447-b7eda7cd3d1b47ffa4785c0eb42a5993",
            "input": "Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-7efcb974b0534f2c8b2cbd1e72260ccf",
            "input": "High-resolution computed tomography scan findings were consistent with ILD, which was sufficient to diagnose as erlotinib-induced ILD.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-17efba801b8044b191f6b8681869912a",
            "input": "RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-1b09d78c987b49af80ecc5f4e9e21c8e",
            "input": "This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.",
            "output": [
                "erlotinib"
            ]
        },
        {
            "id": "task1447-6081e27ff1194c4b8fe92d443ea65c8b",
            "input": "One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.",
            "output": [
                "epinephrine"
            ]
        },
        {
            "id": "task1447-649f58d9f0474303bd3a78478478ac5b",
            "input": "The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.",
            "output": [
                "epinephrine"
            ]
        },
        {
            "id": "task1447-00bd795e5487416ba3ad423b9b0bbc37",
            "input": "However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-32877e2c020340b1b0362f04325a1686",
            "input": "Thrombocytosis associated with enoxaparin: A very rare cause in newborns.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-19840a00cc894de0ae9e356f9f6ab9bd",
            "input": "Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.",
            "output": [
                "enoxaparin"
            ]
        },
        {
            "id": "task1447-4ac08c9dcbb44db7b41ead18c9a91c81",
            "input": "Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.",
            "output": [
                "hydroxychloroquine"
            ]
        },
        {
            "id": "task1447-5c0f4b17e75a4f6e890c26cc19f0ee5b",
            "input": "Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.",
            "output": [
                "TMP-SMX"
            ]
        },
        {
            "id": "task1447-88159903ed45421bab709a4782b9a1a6",
            "input": "Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.",
            "output": [
                "Trimethoprim-sulfamethoxazole"
            ]
        },
        {
            "id": "task1447-be4020e9e58844028afb48a492c029f1",
            "input": "Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.",
            "output": [
                "TMP-SMX"
            ]
        },
        {
            "id": "task1447-a853654b753246e78f7db02db204be22",
            "input": "We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.",
            "output": [
                "TMP-SMX"
            ]
        },
        {
            "id": "task1447-2f82a6a59a914408885f9811630824b2",
            "input": "Amiodarone was discontinued, and thyrotoxicosis gradually abated.",
            "output": [
                "Amiodarone"
            ]
        },
        {
            "id": "task1447-c591deb12742476283f9b184d43e7a21",
            "input": "BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.",
            "output": [
                "sirolimus"
            ]
        },
        {
            "id": "task1447-d56e405e5bd74e0d9a65abfb83289922",
            "input": "Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.",
            "output": [
                "calcineurin"
            ]
        },
        {
            "id": "task1447-31a697d5d9c1444fa93e08fe0f0c9316",
            "input": "These findings mean that the effect of the MP pulse therapy on renal function depends on the clinical state of the patient and that renal deterioration after the pulse therapy may be more marked in patients who are more nephrotic and more impaired in renal function and suggest that increasing sodium and water retention during an MP therapy and the associated renal interstitial edema, proposed as one of the mechanisms of acute renal failure occurring in patients with minimal-change nephrotic syndrome, may be responsible for the MP-induced transient renal failure.",
            "output": [
                "MP"
            ]
        },
        {
            "id": "task1447-e4157915c07149b6b4632a199a9b17ad",
            "input": "A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-b55af7b943704e02822f4f1acc9314c1",
            "input": "It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-cabdca4f7a1f43cc9283fedb6ebd5ad3",
            "input": "A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.",
            "output": [
                "calcium hopantenate"
            ]
        },
        {
            "id": "task1447-08e06b55cbaf4744bd89f2037cd9789d",
            "input": "Persistent light reactivity from systemic quinine.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-34752355ff414b6ca0ea28d88bf8994f",
            "input": "The photosensitivity is still present 3 years after the withdrawal of quinine.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-7ddc7f9181e04ea395137810e335ca88",
            "input": "A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-822802d7690141739a3d6022171e1e7a",
            "input": "Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-ee7a9ddd54b4421c8c6287c6e81196fe",
            "input": "A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.",
            "output": [
                "tPA"
            ]
        },
        {
            "id": "task1447-6e5c626e0d844fc0965f5986d775324a",
            "input": "Splenic hemorrhage: a complication of tissue plasminogen activator treatment.",
            "output": [
                "tissue plasminogen activator"
            ]
        },
        {
            "id": "task1447-3c96f46f90e24d97946994c08a401bbd",
            "input": "A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-790c8d9df42548e497889f460612a893",
            "input": "Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-bf765b5c30ca49158eb6173cfec0e636",
            "input": "Severe hepatitis caused by cyproterone acetate.",
            "output": [
                "cyproterone acetate"
            ]
        },
        {
            "id": "task1447-5ee657550fd64082a9dd660ad949e9b9",
            "input": "A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.",
            "output": [
                "iothalamate"
            ]
        },
        {
            "id": "task1447-d2daeccb00cc4f4d8be8166015ba3ac5",
            "input": "One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.",
            "output": [
                "griseofulvin"
            ]
        },
        {
            "id": "task1447-6c2d15cb04e24a0e8235c7d56a67b16c",
            "input": "Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.",
            "output": [
                "Aminoglutethimide"
            ]
        },
        {
            "id": "task1447-d7c4705039a74b72b158e6fad8c37ea8",
            "input": "Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.",
            "output": [
                "aminoglutethimide"
            ]
        },
        {
            "id": "task1447-7101e5a57d01476c817a7eca25e08497",
            "input": "We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.",
            "output": [
                "aminoglutethimide"
            ]
        },
        {
            "id": "task1447-96558eae1d3e4c21989710887dc33b88",
            "input": "Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-f1169b7186cb43c6aed6380f7d0804ae",
            "input": "The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-f44d16b479514649b31a0a1a1812d3d2",
            "input": "Disulfiram-induced hepatitis.",
            "output": [
                "Disulfiram"
            ]
        },
        {
            "id": "task1447-c68d1c0a41d04c3f8731345d74e4e69b",
            "input": "We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-def399e90fa44613970c7daa1a5befef",
            "input": "Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-376f1b31904446a696db20b914240bd6",
            "input": "We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-944e40394ac7431e894f77b234f1540a",
            "input": "Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.",
            "output": [
                "alum"
            ]
        },
        {
            "id": "task1447-25a46b1ee9774e3e834381cd1913a86a",
            "input": "Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.",
            "output": [
                "lidocaine"
            ]
        },
        {
            "id": "task1447-ba51f3cfe8084c0180d1651f05ef3440",
            "input": "Nitrendipine-induced gingival hyperplasia.",
            "output": [
                "Nitrendipine"
            ]
        },
        {
            "id": "task1447-3100cafea35f4591bbeda4cb63a8ecca",
            "input": "Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.",
            "output": [
                "Nitrendipine"
            ]
        },
        {
            "id": "task1447-8f645da0b8ac4efd8d9c248f1b90a9a8",
            "input": "Physicians using this \"new\" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.",
            "output": [
                "sulfonamide"
            ]
        },
        {
            "id": "task1447-def76e0894bd4d218b89c902df49b5d6",
            "input": "Sulfadiazine crystalluria revisited.",
            "output": [
                "Sulfadiazine"
            ]
        },
        {
            "id": "task1447-b0fc8c51a5ed465cb7881699320854ed",
            "input": "Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-c219b048661e4761b4f4d1ae8c07f8be",
            "input": "We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-efb3c8339fce4acd848f2f58350698f4",
            "input": "Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.",
            "output": [
                "sucralfate"
            ]
        },
        {
            "id": "task1447-2673fd3365a34f63a384990dcbb2ec54",
            "input": "Acute coronary events following cisplatin-based chemotherapy.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-f3f113e4764040fa8ab5c6c4b8f59c98",
            "input": "Bowel perforation associated with intraperitoneal chromic phosphate instillation.",
            "output": [
                "chromic phosphate"
            ]
        },
        {
            "id": "task1447-568b1893556b416cad4f79ace6b1ba08",
            "input": "Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.",
            "output": [
                "chromic phosphate"
            ]
        },
        {
            "id": "task1447-57fce99e06fc45619c38e4526a4c67c7",
            "input": "This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.",
            "output": [
                "chromic phosphate"
            ]
        },
        {
            "id": "task1447-6e4d7755e1734b328f48dd4e4868cc38",
            "input": "Bromide intoxication secondary to pyridostigmine bromide therapy.",
            "output": [
                "pyridostigmine bromide"
            ]
        },
        {
            "id": "task1447-521d5c2505cf461188d8cf33baf2f3a5",
            "input": "To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.",
            "output": [
                "pyridostigmine bromide"
            ]
        },
        {
            "id": "task1447-6ce1bd92c14a480b81e43f98001fc11e",
            "input": "Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.",
            "output": [
                "Diazepam"
            ]
        },
        {
            "id": "task1447-3252d4f9116f449382444299ba17e1f6",
            "input": "We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.",
            "output": [
                "nimodipine"
            ]
        },
        {
            "id": "task1447-68738e93049042dcab248c3cd8b2a4da",
            "input": "After discontinuation of danazol the diabetes completely resolved.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-ea3630b7bb6b4c75833671c93908a0e2",
            "input": "Insulin-dependent diabetes mellitus associated with danazol.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-1209b819c48441dc90a3ee94d91f3089",
            "input": "Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-90b0430be5a043d5909f804d983274c9",
            "input": "Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.",
            "output": [
                "Ifosfamide"
            ]
        },
        {
            "id": "task1447-7680996726d54dcba936272f5c11e06c",
            "input": "Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-c5475aaeaef14b8d915aeb39f9386c5e",
            "input": "We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-38bcb99ba18f4207ac2ec4eaca6a6947",
            "input": "Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.",
            "output": [
                "Ciprofloxacin"
            ]
        },
        {
            "id": "task1447-4a1152ad9e7d4ecd9ad27b492a0e150a",
            "input": "Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-56f4777a9de64443a17695b3ba9f0c91",
            "input": "Suspected ciprofloxacin-induced interstitial nephritis.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-fb0c9ed87ce34b4a9cb5fdc4d28c3e71",
            "input": "This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.",
            "output": [
                "ciprofloxacin"
            ]
        },
        {
            "id": "task1447-6b4626b23ff54902beed86a13c05d612",
            "input": "Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-a44337cdd7c341efb55fb9b51f1aaab2",
            "input": "Phenobarbital hepatotoxicity in an 8-month-old infant.",
            "output": [
                "Phenobarbital"
            ]
        },
        {
            "id": "task1447-99fc7f43a2ce400fb6c093bdc71fa632",
            "input": "Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.",
            "output": [
                "phenobarbital"
            ]
        },
        {
            "id": "task1447-810b54bd0765413c8de5eb0e69f51287",
            "input": "Atenolol-induced pseudolymphoma.",
            "output": [
                "Atenolol"
            ]
        },
        {
            "id": "task1447-36aa0c43c78d46618194e6d080a7467b",
            "input": "Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.",
            "output": [
                "sulpiride"
            ]
        },
        {
            "id": "task1447-b582856690e24af5a02187c4f48dd7ed",
            "input": "Tardive dyskinesia induced by sulpiride.",
            "output": [
                "sulpiride"
            ]
        },
        {
            "id": "task1447-7d5e7ca4d3984aaeb0aeaa1502a914fb",
            "input": "These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.",
            "output": [
                "sulpiride"
            ]
        },
        {
            "id": "task1447-3d357b2e1e5a414fa487ebab8f4e2cb4",
            "input": "We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.",
            "output": [
                "sulpiride"
            ]
        },
        {
            "id": "task1447-0176992e3aaa4954817571141200aa3c",
            "input": "This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-a332ca85e01140bca97dd5cdae8550bd",
            "input": "Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-1e87dd066f914ea6a355ea70601f766d",
            "input": "Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-e18195f181cb46fe9117ef5947f47c46",
            "input": "The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-fdb27a89cd4940d9b69465fd670daed5",
            "input": "Quinine-induced hearing loss.",
            "output": [
                "Quinine"
            ]
        },
        {
            "id": "task1447-fd7236d41efd45eb85ecda0e4486d041",
            "input": "Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-3c9cf528aee547f1b5344f07a7ea10ea",
            "input": "The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-64c219ac62e641c695a078a94bb8e599",
            "input": "The ototoxicity of quinine can accurately be studied with ultrahigh frequency audiometry (up to 20 kHz).",
            "output": [
                "quinine"
            ]
        },
        {
            "id": "task1447-aee3a9ae4df64ef0a6d6379d58490b10",
            "input": "Bleomycin pneumonitis potentiated by oxygen administration.",
            "output": [
                "Bleomycin"
            ]
        },
        {
            "id": "task1447-caf3a68413a143ab9187215650676f8e",
            "input": "A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-542e1e6dbb2f4d7ba5a7b04a6d9b70fd",
            "input": "Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-d883483ff2524f109599e1d2d853a521",
            "input": "In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-3fc96d29acce43cda01f01458a2b7129",
            "input": "Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.",
            "output": [
                "Procainamide"
            ]
        },
        {
            "id": "task1447-680af22cfeb24784be0208aaa8adf464",
            "input": "The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-a98eba8ef3b84576afac63dbd220a119",
            "input": "Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.",
            "output": [
                "phosphate diethylstilbestrol"
            ]
        },
        {
            "id": "task1447-e3ce84b8e5c046fe8d52a3755ba042bf",
            "input": "Life-threatening hyponatremia caused by vinblastine.",
            "output": [
                "vinblastine"
            ]
        },
        {
            "id": "task1447-f8f5d0259254458c820339b80671b0aa",
            "input": "The most likely cause of such hyponatremic episode is vinblastine.",
            "output": [
                "vinblastine"
            ]
        },
        {
            "id": "task1447-6100a43f9cf8421fba33db31b7723a1b",
            "input": "We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-ca2303909c734cb78dfe11f62d4fd2ec",
            "input": "A typical case of dextran-40 associated acute renal failure is presented.",
            "output": [
                "dextran-40"
            ]
        },
        {
            "id": "task1447-46166c2652ec4d378572990d7026d461",
            "input": "Renal failure associated with the use of dextran-40.",
            "output": [
                "dextran-40"
            ]
        },
        {
            "id": "task1447-4db64b511aee494fb82f487753eb3937",
            "input": "Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.",
            "output": [
                "dextran-40"
            ]
        },
        {
            "id": "task1447-7f4706b74044496f926ef553fd85b0e9",
            "input": "While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.",
            "output": [
                "dextran"
            ]
        },
        {
            "id": "task1447-b222b17431c2445dae72babb4aa0b9c5",
            "input": "A 57-year-old man developed morphea while taking bromocriptine.",
            "output": [
                "bromocriptine"
            ]
        },
        {
            "id": "task1447-4b990616df9c4891b03892bca138c233",
            "input": "Morphea after bromocriptine therapy.",
            "output": [
                "bromocriptine"
            ]
        },
        {
            "id": "task1447-69ac0ac7ea9c4aed8f436dcfd5b5bf89",
            "input": "A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-ca5674f839bc4ddca1fa7044a065c46c",
            "input": "Dapsone-induced erythroderma with Beau's lines.",
            "output": [
                "Dapsone"
            ]
        },
        {
            "id": "task1447-8272061550a24e2a809cbb94149123bc",
            "input": "Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-33587eb664d1490fba7f9b15ffbbf491",
            "input": "Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-4599288f6e3042d1b6cc631b26d20832",
            "input": "Fluoxetine-induced akathisia: clinical and theoretical implications.",
            "output": [
                "Fluoxetine"
            ]
        },
        {
            "id": "task1447-10397e5fb376494cb4b266cdd4232ffb",
            "input": "Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-bf85f673dc184bf58d38a68f72d08fd7",
            "input": "Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.",
            "output": [
                "cytosine arabinoside"
            ]
        },
        {
            "id": "task1447-f85598e54dd54ef5a99bc7ce8d0a2cab",
            "input": "Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.",
            "output": [
                "cytosine arabinoside"
            ]
        },
        {
            "id": "task1447-40320f84921a4a749f8bfa89e80eeb9f",
            "input": "Nail-changes induced by penicillamine.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-20b561b5bd104baaaf272db9e0b06153",
            "input": "Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-aa209eb412b244a6a7ac0eb636c68910",
            "input": "Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-8897de3132b44cec8799ae934a8470a6",
            "input": "Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.",
            "output": [
                "Ibuprofen"
            ]
        },
        {
            "id": "task1447-debef0ff87f54bce876f125f9eccfd83",
            "input": "We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-16b07596ed45467eb2edd8eedef98cea",
            "input": "Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.",
            "output": [
                "Metoclopramide"
            ]
        },
        {
            "id": "task1447-24937d3c49a343528cb7462befc774b3",
            "input": "Metoclopramide-induced parkinsonism.",
            "output": [
                "Metoclopramide"
            ]
        },
        {
            "id": "task1447-43479b09df3b47a48156c5f3182ccd8f",
            "input": "Their parkinsonism improved on discontinuation of metoclopramide therapy.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-31997b8a3f85426481cab3faeb46df80",
            "input": "We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.",
            "output": [
                "metoclopramide"
            ]
        },
        {
            "id": "task1447-8efa8698ac3b4b19b6960cf08eb2c3df",
            "input": "Clofazimine induced nail changes.",
            "output": [
                "Clofazimine"
            ]
        },
        {
            "id": "task1447-c1bd28c0a4f04f52a1d4015674278755",
            "input": "These nail changes gradually disappeared when the dose of clofazimine was reduced.",
            "output": [
                "clofazimine"
            ]
        },
        {
            "id": "task1447-12564bce43d44758a925e0fca86fd808",
            "input": "Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.",
            "output": [
                "asparaginase"
            ]
        },
        {
            "id": "task1447-e5b78f9f23244d4aafe4edc87c79d5a8",
            "input": "Development of persistent late onset asthma following treatment with captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-7a5ba98b0a40498d868fb142025ad841",
            "input": "We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-38774f195fa64ac5811d4651a33b3bd0",
            "input": "Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-46dbcde1f02c4a58ad6d362a51636b7b",
            "input": "Amiodarone induced torsades de pointe.",
            "output": [
                "Amiodarone"
            ]
        },
        {
            "id": "task1447-43a3bdac906f465090c9dad0a9992317",
            "input": "We report three cases of amiodarone-induced torsades de pointe.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-bd56381c49084c4a8c6b15f6475ee120",
            "input": "The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-85aa195e3f474ba88455be5c8e0cfaab",
            "input": "Long lasting respiratory depression induced by morphine-6-glucuronide?",
            "output": [
                "morphine-6-glucuronide"
            ]
        },
        {
            "id": "task1447-6e5b12d21b9448e19bed387c1d6765a2",
            "input": "We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-22f174004ec546518cb1a12432b9bc60",
            "input": "Rifampin-associated thrombocytopenia secondary to poor compliance.",
            "output": [
                "Rifampin"
            ]
        },
        {
            "id": "task1447-27f444670a0044b2a8c3b7bd85cf85a9",
            "input": "This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.",
            "output": [
                "rifampin"
            ]
        },
        {
            "id": "task1447-a1207d8cb515425d879219c31d9c75a4",
            "input": "We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-abcf53fc06754f5ab83567f25a4c1824",
            "input": "Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-7960f626c6fd4daabaafef18417e6224",
            "input": "Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.",
            "output": [
                "Ibuprofen"
            ]
        },
        {
            "id": "task1447-678f839b496946e28320d42c1ce9936d",
            "input": "Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-51074e550ebe48d594e7825e46e4bf1b",
            "input": "We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-a67b0065689d4739bedab2ddf8996222",
            "input": "Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-efa82903747d4a8ca14bfb3b8dc281f4",
            "input": "Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-fc9ff499c9bd4dedb62bbbdadd76b79d",
            "input": "Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-f2396cbf12af4c7e80ed09128afba9d6",
            "input": "After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-5e995395b3f04771b153d787c352ba49",
            "input": "Panic anxiety after abrupt discontinuation of mianserin.",
            "output": [
                "mianserin"
            ]
        },
        {
            "id": "task1447-451d2a222e6e4606b3aaaf7d5b689587",
            "input": "This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.",
            "output": [
                "mianserin"
            ]
        },
        {
            "id": "task1447-357c4d861ee24a349ac982912482271d",
            "input": "Prior neurologic illness and the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-676ec09b016c467598a9a609eda942b1",
            "input": "Prior neurologic illness or CNS insult of any kind is known to increase the vulnerability to neurotoxicity of lithium.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-cdaa99f074ff46f98c23aafefd79e6fb",
            "input": "The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-81f68c48784742ceac91a8140a2fc915",
            "input": "Life-threatening cranial dystonia following trihexyphenidyl withdrawal.",
            "output": [
                "trihexyphenidyl"
            ]
        },
        {
            "id": "task1447-63069fee39064126a88ab480e39b72b2",
            "input": "Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.",
            "output": [
                "Ara-C"
            ]
        },
        {
            "id": "task1447-0c7a2cfb220a4f17822389afe0a32ce2",
            "input": "Paraplegia following intrathecal cytosine arabinoside.",
            "output": [
                "cytosine arabinoside"
            ]
        },
        {
            "id": "task1447-130ae8f8159143c89069c02b77ae5d81",
            "input": "Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.",
            "output": [
                "o,p'-DDD"
            ]
        },
        {
            "id": "task1447-583f95eef0554068b2a719a0d3690afe",
            "input": "Alprazolam-induced mania: two clinical cases.",
            "output": [
                "Alprazolam"
            ]
        },
        {
            "id": "task1447-e503c008c08548e7a4d883ac1d861705",
            "input": "The authors caution that treatment with alprazolam may be complicated by the induction of mania.",
            "output": [
                "alprazolam"
            ]
        },
        {
            "id": "task1447-293a682a7f5c4d698f80291b7a056088",
            "input": "Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.",
            "output": [
                "alprazolam"
            ]
        },
        {
            "id": "task1447-cd5a3a626aa045209f52182ddedaa0a6",
            "input": "A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.",
            "output": [
                "alprazolam"
            ]
        },
        {
            "id": "task1447-b003bc4a2a7b4c51b5e440936bedf1a7",
            "input": "Alprazolam withdrawal delirium unresponsive to diazepam: case report.",
            "output": [
                "Alprazolam"
            ]
        },
        {
            "id": "task1447-4824345a2aab4e57b3bb16ad70e6763f",
            "input": "We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.",
            "output": [
                "sulfasalazine"
            ]
        },
        {
            "id": "task1447-c30322c27dd545499f423d0e31c0687f",
            "input": "Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-ef67022574c548a5aa63ded0aeda64fe",
            "input": "Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-6d989018406d4ca0a23e206b26cfbca6",
            "input": "Exacerbation of schizophrenia associated with amantadine.",
            "output": [
                "amantadine"
            ]
        },
        {
            "id": "task1447-94d7d3dac0034cb980b1d395e0378f54",
            "input": "Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.",
            "output": [
                "chlorpromazine"
            ]
        },
        {
            "id": "task1447-d29123038bb3436baf201c3d9fef3404",
            "input": "Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.",
            "output": [
                "sulfasalazine"
            ]
        },
        {
            "id": "task1447-3fa1e60631c54536bfc21ce807bd03c1",
            "input": "Sulfasalazine-induced lupus erythematosus.",
            "output": [
                "Sulfasalazine"
            ]
        },
        {
            "id": "task1447-41ec3f2f27cd41fcbfcbfb832f52ba79",
            "input": "Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.",
            "output": [
                "L-thyroxine"
            ]
        },
        {
            "id": "task1447-21a365342c834c4683f75d32113851bd",
            "input": "A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.",
            "output": [
                "L-T4"
            ]
        },
        {
            "id": "task1447-38157150206d41898ad47ff065a3d733",
            "input": "L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.",
            "output": [
                "L-Thyroxine"
            ]
        },
        {
            "id": "task1447-9fb84da82a9146a1a795abe7036093a3",
            "input": "However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-505c012655604386b8838985322aec89",
            "input": "Vancomycin-induced vasculitis.",
            "output": [
                "Vancomycin"
            ]
        },
        {
            "id": "task1447-38c97cde4d1f48f99c0c29aa9a4bd38a",
            "input": "Abnormal retinal function associated with isotretinoin therapy for acne.",
            "output": [
                "isotretinoin"
            ]
        },
        {
            "id": "task1447-31a69204ecdc4dedb359465a440b254b",
            "input": "Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.",
            "output": [
                "FUdR"
            ]
        },
        {
            "id": "task1447-6cb6e0eae68648a7bd530958dc43b03e",
            "input": "Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.",
            "output": [
                "Ethambutol"
            ]
        },
        {
            "id": "task1447-689a8a86b25a42959662ef8e2c984ed0",
            "input": "Optic neuropathy in ethambutol-treated renal tuberculosis.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-d17049c479fb4e92a68ba8da472618cc",
            "input": "Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-898d34ae94f3451e9f830afca0dd6942",
            "input": "A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.",
            "output": [
                "nifedipine"
            ]
        },
        {
            "id": "task1447-0d73a0d6cb0a4edf981bff6e04ab2cc0",
            "input": "Gastro-oesophageal reflux associated with nifedipine.",
            "output": [
                "nifedipine"
            ]
        },
        {
            "id": "task1447-011b445f778c4470bfd9718615c9c7bd",
            "input": "Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.",
            "output": [
                "Nifedipine"
            ]
        },
        {
            "id": "task1447-ad7e8d2dfc7c4114827eabaf807a4cdd",
            "input": "Cataracts induced by intermittent Decadron used as an antiemetic.",
            "output": [
                "Decadron"
            ]
        },
        {
            "id": "task1447-c7cf728f936147e89b359e6f81d54883",
            "input": "Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-9e49b894b14b4d07bd9002af140ad247",
            "input": "The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.",
            "output": [
                "chloral hydrate"
            ]
        },
        {
            "id": "task1447-e44af11b43e64464bbf9ff411c6b098f",
            "input": "Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.",
            "output": [
                "Adrenaline"
            ]
        },
        {
            "id": "task1447-06a2a89d873340869164d09017092411",
            "input": "Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.",
            "output": [
                "adrenaline"
            ]
        },
        {
            "id": "task1447-812f86ca1d1d45078605d58fb011dc68",
            "input": "Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-68c9c1db42ce4f3388b98e1716e72156",
            "input": "Reversible valproic acid-induced dementia: a case report.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-38de971fd9a74965b25fc44698486636",
            "input": "Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-f19b952b60ab48bbbe12a03041b4b38f",
            "input": "Co-trimoxazole red cell aplasia in leukaemia.",
            "output": [
                "Co-trimoxazole"
            ]
        },
        {
            "id": "task1447-252b71b3b4f34855ab36b4baa25c54b2",
            "input": "When co-trimoxazole was stopped the red cell aplasia resolved.",
            "output": [
                "co-trimoxazole"
            ]
        },
        {
            "id": "task1447-2beafc1f7ab64b1c8cb3e31aa4467b64",
            "input": "A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.",
            "output": [
                "Depo-Medrol"
            ]
        },
        {
            "id": "task1447-db1c3622d5e341289e8fbb5097c4e693",
            "input": "Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.",
            "output": [
                "adrenocorticotropic hormone"
            ]
        },
        {
            "id": "task1447-389d600b0b914370829933a729271fa1",
            "input": "Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.",
            "output": [
                "ACTH"
            ]
        },
        {
            "id": "task1447-b6240082030343a9be8991c49d4a056e",
            "input": "We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.",
            "output": [
                "ACTH"
            ]
        },
        {
            "id": "task1447-8ed63de0e51c4579b1621a1f1a72392c",
            "input": "Accordingly, camptocormia is a dose-dependent side effect of valproate.",
            "output": [
                "valproate"
            ]
        },
        {
            "id": "task1447-79c6a889390a4e63a5f6ffe9c59124e5",
            "input": "Camptocormia, a new side effect of sodium valproate.",
            "output": [
                "sodium valproate"
            ]
        },
        {
            "id": "task1447-50fffc7e9a0f47d3a0d48a243dbf848c",
            "input": "A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.",
            "output": [
                "lorazepam"
            ]
        },
        {
            "id": "task1447-db2282568840409cb7d0664bd26a4691",
            "input": "Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.",
            "output": [
                "lorazepam"
            ]
        },
        {
            "id": "task1447-c2580b933dd0479f9731256cff9b630e",
            "input": "Atrial fibrillation following methylprednisolone pulse therapy.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-c263b01e29f24c2fb2d6be5201404be1",
            "input": "Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.",
            "output": [
                "Isotretinoin"
            ]
        },
        {
            "id": "task1447-578817d9ec31458c99fb28b390a45e56",
            "input": "Isotretinoin teratogenicity.",
            "output": [
                "Isotretinoin"
            ]
        },
        {
            "id": "task1447-b4c5e74bf3994c108e8d1345947ea2eb",
            "input": "A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.",
            "output": [
                "allopurinol"
            ]
        },
        {
            "id": "task1447-8c077b4e6bb74b849e66f6d32f05969a",
            "input": "Allopurinol hypersensitivity.",
            "output": [
                "Allopurinol"
            ]
        },
        {
            "id": "task1447-7f8f0de95e72478fbf55b7611237acb4",
            "input": "The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.",
            "output": [
                "allopurinol"
            ]
        },
        {
            "id": "task1447-5433a88c3a6a41f2af428bd6d13bcf06",
            "input": "Bone formation induced in an infant by systemic prostaglandin-E2 administration.",
            "output": [
                "prostaglandin-E2"
            ]
        },
        {
            "id": "task1447-28fe6f22e59d419ebbfed5031825808f",
            "input": "A case of severe visual loss following a single dose of vincristine is described.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-a0829e68f5204f98a716f69bcb130e9c",
            "input": "Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-a554a9fb226f4a70bd936fe026c691a9",
            "input": "Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-c6445ffae05e4e198d16d67653578ad8",
            "input": "The literature of vincristine optic nerve toxicity is reviewed.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-ea8cc1d2df494caa8c3b102da6266ebb",
            "input": "Visual loss after a single small dose of vincristine has never been reported.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-03432ba665d845808dc6c54a586eab6e",
            "input": "Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.",
            "output": [
                "Niacin"
            ]
        },
        {
            "id": "task1447-0485f72656984acc921653d09619837c",
            "input": "Niacin maculopathy.",
            "output": [
                "Niacin"
            ]
        },
        {
            "id": "task1447-fa88ff00d1b44009a9f211ce02e4b943",
            "input": "The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.",
            "output": [
                "niacin"
            ]
        },
        {
            "id": "task1447-081b2622feef4cea960d59246e1e9d4e",
            "input": "A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-678016d0b9de459da764af705137e2d9",
            "input": "Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-92fed1f724a34a90af14be1c5049e322",
            "input": "Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.",
            "output": [
                "Rifampicin"
            ]
        },
        {
            "id": "task1447-43a6ba24a3da4a6684f4a1e7e65c6c11",
            "input": "We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-324ed806f70f4c63a07fc0862349125d",
            "input": "Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.",
            "output": [
                "diltiazem"
            ]
        },
        {
            "id": "task1447-d2054bfcf02448a7aefc48125df9d239",
            "input": "Widespread cutaneous vasculitis associated with diltiazem.",
            "output": [
                "diltiazem"
            ]
        },
        {
            "id": "task1447-b99103388471477c942297835ed8cf1b",
            "input": "Intraventricular nafcillin-induced seizures in a neonate.",
            "output": [
                "nafcillin"
            ]
        },
        {
            "id": "task1447-0108da9087c441c0b28eafe593571e54",
            "input": "We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.",
            "output": [
                "nafcillin"
            ]
        },
        {
            "id": "task1447-2b3ac38a194d4cbcbf1ad01d827f0a0a",
            "input": "A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-a10d81cbd21e450fb0ca535fd50f0a12",
            "input": "Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-377f3d82e1cf460cbf36959a2a7a3c1e",
            "input": "Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.",
            "output": [
                "doxycycline"
            ]
        },
        {
            "id": "task1447-d579ad07695d416987537d1d4b87cab4",
            "input": "A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.",
            "output": [
                "human growth hormone"
            ]
        },
        {
            "id": "task1447-9b18c3401c2f4f36bb8e9c285e641f30",
            "input": "A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.",
            "output": [
                "human growth hormone"
            ]
        },
        {
            "id": "task1447-af5cd4e95642430cad0306a3f9fb2a6c",
            "input": "A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.",
            "output": [
                "choline magnesium trisalicylate"
            ]
        },
        {
            "id": "task1447-181d20ff839d44508c4ff380f9abe36d",
            "input": "Salicylate-induced hepatotoxicity is reviewed.",
            "output": [
                "Salicylate"
            ]
        },
        {
            "id": "task1447-30541863f281458d8c05fd5253313c3b",
            "input": "They continued to rise for five more days before salicylate hepatotoxicity was suspected.",
            "output": [
                "salicylate"
            ]
        },
        {
            "id": "task1447-5893b870295f4d5781364d5bf04c4273",
            "input": "Captopril-related (and -induced?) asthma.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-2a254e6f80af4a88b9fc8062d1e91b63",
            "input": "This confirmed the history of captopril-related asthma.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-5e154eff3a0d4e76bc2c8cc16873f2fc",
            "input": "We also describe a case of timolol-induced ocular pemphigoid.",
            "output": [
                "timolol"
            ]
        },
        {
            "id": "task1447-1157afbc0a6f4d4ab23dfd16baf30ed1",
            "input": "Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.",
            "output": [
                "Benzocaine"
            ]
        },
        {
            "id": "task1447-62248bdad575438f838c59cf658ec484",
            "input": "Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.",
            "output": [
                "Benzocaine"
            ]
        },
        {
            "id": "task1447-3b3c62d611764feab88c8cf01d87a4e2",
            "input": "Methemoglobinemia associated with dermal application of benzocaine cream in a cat.",
            "output": [
                "benzocaine"
            ]
        },
        {
            "id": "task1447-ae02101711894326a39d667a72094257",
            "input": "A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-42670bb56d0b44fe82ae4422336a4aa5",
            "input": "Erosion of psoriatic plaques after chronic methotrexate administration.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-d74a27a7e8574b4993174db7a819e411",
            "input": "Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.",
            "output": [
                "cyclosporine A"
            ]
        },
        {
            "id": "task1447-edef1afa234947beb0bbc6650a7af68e",
            "input": "Polymyositis after propylthiouracil treatment for hyperthyroidism.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-4a5b6af8b63844e9870b6959fb36d665",
            "input": "Cardiopulmonary arrest following intravenous phenytoin loading.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-6f4046e4d892473a9d6831d575114f60",
            "input": "Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.",
            "output": [
                "calcium hopantenate"
            ]
        },
        {
            "id": "task1447-417c1b46f84343769e4d4383bccdd0e9",
            "input": "Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.",
            "output": [
                "calcium hopantenate"
            ]
        },
        {
            "id": "task1447-3a432635d08b47d282a3d184413b7f59",
            "input": "Dyspnea possibly associated with controlled-release morphine sulfate tablets.",
            "output": [
                "morphine sulfate"
            ]
        },
        {
            "id": "task1447-2f6e458db9494fa59b098d1aa7f77000",
            "input": "Anhedonic ejaculation with desipramine.",
            "output": [
                "desipramine"
            ]
        },
        {
            "id": "task1447-dd977caf9f7f4d129105783e80a2f2c2",
            "input": "Myoclonic spasms following intrathecal morphine.",
            "output": [
                "morphine"
            ]
        },
        {
            "id": "task1447-9e25f0efb1d7494b86ab6d98cc327e36",
            "input": "A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.",
            "output": [
                "halothane"
            ]
        },
        {
            "id": "task1447-73d8a6049cd04b9ab10dd30e615e93e6",
            "input": "Halothane hepatitis and prompt resolution with methionine therapy: case report.",
            "output": [
                "Halothane"
            ]
        },
        {
            "id": "task1447-92daa4f9aeee4b44958c703959cada96",
            "input": "Development of porphyria cutanea tarda after treatment with cyclophosphamide.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-a6e0503408c74a3f928d604a12cf1ec0",
            "input": "We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.",
            "output": [
                "PI"
            ]
        },
        {
            "id": "task1447-33157e0d2fe94dbd90b5c4a4d3f95dd8",
            "input": "D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-f627b4fd17064430939dc4dc84881eba",
            "input": "The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-b8f848611e634f638de8700e2ab20cbc",
            "input": "Gold-induced pneumonitis is a rare complication of gold salt therapy.",
            "output": [
                "Gold"
            ]
        },
        {
            "id": "task1447-02fd5b603a714b42af06745d9ab8d869",
            "input": "Gold-induced pneumonitis.",
            "output": [
                "Gold"
            ]
        },
        {
            "id": "task1447-ee4618133abb40c6be37cb2232428c27",
            "input": "This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-c1c57a16c85445a88230ffa72b81a2b9",
            "input": "We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-b47a60d053ae411d9bdd41bc72e606d6",
            "input": "Gold-induced aplastic anemia.",
            "output": [
                "Gold"
            ]
        },
        {
            "id": "task1447-7aadb906878f452185f91f6f51da0d6b",
            "input": "Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-8fd4c89e93834f4db6d5cbd0e478efaf",
            "input": "Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.",
            "output": [
                "6-mercaptopurine"
            ]
        },
        {
            "id": "task1447-aa3eeccb82a94fab81b9a7e13b9eeb83",
            "input": "Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.",
            "output": [
                "HDARAC"
            ]
        },
        {
            "id": "task1447-48afddf5de364aeb92b74c70601345ad",
            "input": "Cytarabine-induced cerebellar syndrome: case report and literature review.",
            "output": [
                "Cytarabine"
            ]
        },
        {
            "id": "task1447-f954fe68f14443448776bf102cc65091",
            "input": "The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.",
            "output": [
                "HDARAC"
            ]
        },
        {
            "id": "task1447-e6e26bb42f084da2a4e427681fd4777d",
            "input": "This case report illustrates the neurotoxicity unique to HDARAC.",
            "output": [
                "HDARAC"
            ]
        },
        {
            "id": "task1447-4dd8fe0210134401a4e7a0cf8f6a5325",
            "input": "Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.",
            "output": [
                "gentamicin"
            ]
        },
        {
            "id": "task1447-2dcf5d27faf741bd900d2f04c46a65b2",
            "input": "We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.",
            "output": [
                "gentamicin"
            ]
        },
        {
            "id": "task1447-e33ff194a01249e9b2d4d7205790995d",
            "input": "A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.",
            "output": [
                "razoxane"
            ]
        },
        {
            "id": "task1447-48d8c7a0f5d046099708079652d2cfff",
            "input": "Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-e8ef9e99f2234aaea1c313101b2835a8",
            "input": "Hypogammaglobulinemia associated with gold therapy: evidence for a partial maturation blockade of B cells.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-d783347b436e44be9f30a4f544be643e",
            "input": "Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.",
            "output": [
                "cyclosporine A"
            ]
        },
        {
            "id": "task1447-4d01b08f4b2f46fab7dc2a5542b774b6",
            "input": "We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.",
            "output": [
                "Cyclosporine A"
            ]
        },
        {
            "id": "task1447-3c1382f661e14942966c49dd53518577",
            "input": "With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.",
            "output": [
                "Cyclosporine A"
            ]
        },
        {
            "id": "task1447-26b48f6dbabe4ff69683198557d80fb5",
            "input": "Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-960ac934fdd24041a035419ec91a0d10",
            "input": "Captopril-induced lichen planus pemphigoides with pemphigus-like features.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-7ce5ba70c1ed4bf6ab4114bf358f4352",
            "input": "We report a case of a bullous lichenoid eruption due to the intake of captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-ed1fd7d95465485ead7d49e1ed59a394",
            "input": "An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.",
            "output": [
                "BCG"
            ]
        },
        {
            "id": "task1447-13041ff1397546a29f85da5e2bf799a9",
            "input": "Metastatic osteomyelitis following BCG vaccination.",
            "output": [
                "BCG"
            ]
        },
        {
            "id": "task1447-40f5e3efa3364139a96e1ce549906460",
            "input": "Amoxapine-induced cognitive impairment in two patients.",
            "output": [
                "Amoxapine"
            ]
        },
        {
            "id": "task1447-3e9c7f1f201b4d9f87e4d78360c683ac",
            "input": "Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.",
            "output": [
                "amoxapine"
            ]
        },
        {
            "id": "task1447-9e4dc7931d674e71bb863211661cdc6a",
            "input": "A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-3ce6e27db3624f959f2e7c585bd60701",
            "input": "Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-b333623d59e94f98b8f0701dfc6eebe6",
            "input": "A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.",
            "output": [
                "chloramphenicol"
            ]
        },
        {
            "id": "task1447-8253efdcba604981b987e20258a86836",
            "input": "Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.",
            "output": [
                "chloramphenicol"
            ]
        },
        {
            "id": "task1447-d09e3cdfcbca4a708c859dd047eaa1c8",
            "input": "Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.",
            "output": [
                "chloramphenicol"
            ]
        },
        {
            "id": "task1447-416fe969b1de414fb433042f65dd4c28",
            "input": "We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.",
            "output": [
                "chloramphenicol sodium succinate"
            ]
        },
        {
            "id": "task1447-8c0bbb924ca74d4cb00e8725a9e25cf7",
            "input": "Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-e263843988dd44d5a5c1b98aa7a47422",
            "input": "We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-bb9a2c1afa954ec68e4eb23152921a17",
            "input": "Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-c832c83eeec54f4a8f2335db2d5e0ebc",
            "input": "Other upper tract neoplasms after cyclophosphamide are reviewed.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-56a498a48f3b4504b21518a2349c82eb",
            "input": "Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-9328201b769241dfa037c9d7dc4fa876",
            "input": "Progressive pulmonary fibrosis complicating cyclophosphamide therapy.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-0a50736d9d5748e98b77589fe33bf18c",
            "input": "The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-7415828f6d71423782e9a3a113ad76ea",
            "input": "Torsade de pointes during loading with amiodarone.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-9f3a739fc1cf4e748009cae714429e77",
            "input": "Torsade de pointes represents a potential complication of chronic amiodarone therapy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-07709f26019b4855b8da1051dbdfbbf2",
            "input": "We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-0dd9168b70b24425839b3579c42722a0",
            "input": "Pulmonary edema as a delayed complication of ritodrine therapy.",
            "output": [
                "ritodrine"
            ]
        },
        {
            "id": "task1447-6639be14c394434d8b3e9778a2fadf30",
            "input": "Rupture of a cerebral aneurysm associated with nifedipine treatment.",
            "output": [
                "nifedipine"
            ]
        },
        {
            "id": "task1447-ebe7df4a0e3a40a99c681761f1943776",
            "input": "We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.",
            "output": [
                "nifedipine"
            ]
        },
        {
            "id": "task1447-25918d33ee844da79dfc67c8fc78118e",
            "input": "Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.",
            "output": [
                "Prazosin"
            ]
        },
        {
            "id": "task1447-4907b536c7594b12ba88c91830915bb5",
            "input": "A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-671227639b464c75a690e5ee88278c0d",
            "input": "Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-e32c68babe30425fb9dfda2b03067448",
            "input": "Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.",
            "output": [
                "digoxin"
            ]
        },
        {
            "id": "task1447-d5e7aa8c59d245b5be5050c55066a269",
            "input": "Phenytoin-induced hypersensitivity reactions.",
            "output": [
                "Phenytoin"
            ]
        },
        {
            "id": "task1447-c62045b678cc4028b40c079b2a2dbb8c",
            "input": "It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.",
            "output": [
                "nicotinic acid"
            ]
        },
        {
            "id": "task1447-0bf62f6c51264537959e5a0db76c66f5",
            "input": "Nicotinic acid-induced fulminant hepatic failure.",
            "output": [
                "Nicotinic acid"
            ]
        },
        {
            "id": "task1447-e3d84852fcbb4b91a0dc5da0e2dc8ad8",
            "input": "The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.",
            "output": [
                "methimazole"
            ]
        },
        {
            "id": "task1447-f9523b0795cb4a67b98239f8050a0da7",
            "input": "A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-95fad23e2ad94bb68b538fe2d631fc94",
            "input": "Probable early acute hepatitis with parenteral amiodarone.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-70e82fb949b440a9a4e06784f70edd66",
            "input": "Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-a0b992d1216a4008885b70548859f0ea",
            "input": "He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.",
            "output": [
                "timolol"
            ]
        },
        {
            "id": "task1447-8a343869054f4b3ab2c71b864311a241",
            "input": "Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.",
            "output": [
                "timolol"
            ]
        },
        {
            "id": "task1447-54a063a3f8f34a6092c888e49f6a9cfe",
            "input": "Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-bedd3a8edb364638ade917822686000a",
            "input": "Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.",
            "output": [
                "mono-octanoin"
            ]
        },
        {
            "id": "task1447-518ec498f3f3450b9432485dbe87d816",
            "input": "We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.",
            "output": [
                "monooctanoin"
            ]
        },
        {
            "id": "task1447-a85c5182110249589352341623b64d5b",
            "input": "Acute myocardial necrosis during administration of amsacrine.",
            "output": [
                "amsacrine"
            ]
        },
        {
            "id": "task1447-0408ffe7b7254328b7c4647a166e811f",
            "input": "The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.",
            "output": [
                "phenobarbital"
            ]
        },
        {
            "id": "task1447-fe2e4c2af03546478819b6db69cae1bc",
            "input": "Duodenal ulceration: a complication of tolazoline therapy.",
            "output": [
                "tolazoline"
            ]
        },
        {
            "id": "task1447-1de5b5c3c7434bb68ba34a79a0e39bff",
            "input": "Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-4f0542a6603f45d2b757f679e7bf52ed",
            "input": "Methimazole-associated cholestatic liver injury: case report and brief literature review.",
            "output": [
                "Methimazole"
            ]
        },
        {
            "id": "task1447-ca04775776db4477a9a459eef16b2ef2",
            "input": "The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.",
            "output": [
                "methimazole"
            ]
        },
        {
            "id": "task1447-5bc2ed857bae45ed802ccfca44e16e64",
            "input": "A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.",
            "output": [
                "interferon beta"
            ]
        },
        {
            "id": "task1447-fb42ddd87e1d4fd585ba3e1d24934550",
            "input": "The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.",
            "output": [
                "interferon beta"
            ]
        },
        {
            "id": "task1447-ed6a278843244d4193d3cd49975b727c",
            "input": "Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.",
            "output": [
                "formalin"
            ]
        },
        {
            "id": "task1447-32e53ce57efb458c94f0e534f7a51a70",
            "input": "A lethal complication of peripheral vein vasopressin infusion.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-974113e18b20457da3fc45924ba2b489",
            "input": "Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.",
            "output": [
                "protamine"
            ]
        },
        {
            "id": "task1447-dbf6bff7613f43aab5fe85f7628d607a",
            "input": "Protamine-induced fatal anaphylaxis.",
            "output": [
                "Protamine"
            ]
        },
        {
            "id": "task1447-ee9b8ca36ef2497ca4b8ea565893bfc1",
            "input": "Ototoxicity as a result of cis-platinum administration is well documented.",
            "output": [
                "cis-platinum"
            ]
        },
        {
            "id": "task1447-aeb7f3e6b87e40eaad64958e3097836d",
            "input": "Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.",
            "output": [
                "nitroglycerin"
            ]
        },
        {
            "id": "task1447-4411b267743f4321ad10f352ed2bccaa",
            "input": "Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-acbb9576045f4d8a93ea5ca3b0f56af5",
            "input": "Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals.",
            "output": [
                "Ampicillin"
            ]
        },
        {
            "id": "task1447-7b746edea4574ad7af94f23745ec646c",
            "input": "Ampicillin may aggravate clinical and experimental myasthenia gravis.",
            "output": [
                "Ampicillin"
            ]
        },
        {
            "id": "task1447-73bb727e84a1484190dd21a30fa5a281",
            "input": "Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-c9498103162b4644b79b20c2e7c73f64",
            "input": "One patient had severe temporary weakness after an ampicillin sodium challenge.",
            "output": [
                "ampicillin sodium"
            ]
        },
        {
            "id": "task1447-7929c714ff6f437b913013962724efb4",
            "input": "A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-dc3772d2ff624587bf2feb9d041b4225",
            "input": "Esophageal spasm following propranolol overdose relieved by glucagon.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-da6f8f26c5d64178921ba79e95941a73",
            "input": "Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.",
            "output": [
                "hydrochlorothiazide"
            ]
        },
        {
            "id": "task1447-bacbb40594044fe2a14c864fe6e826c3",
            "input": "Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-460eb7e89ef04ae784634bb91b36961b",
            "input": "However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-ff2494a6ac3b48ba9821eceb1c5d1d11",
            "input": "The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-d3f468a56787439cabf9708475757c21",
            "input": "Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-78c092c0ae1444f4abfc9d26366eee27",
            "input": "Heparin-induced hyperkalemia.",
            "output": [
                "Heparin"
            ]
        },
        {
            "id": "task1447-3e788a107c334f3cab053404bb01d8bb",
            "input": "We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.",
            "output": [
                "heparin"
            ]
        },
        {
            "id": "task1447-91809780bec34e48aedfa80b02e871ba",
            "input": "Careful follow-up of so-called \"self-limited\" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-92701215bcca41b3bf71dde9e4463729",
            "input": "Insulin-induced cardiac failure.",
            "output": [
                "Insulin"
            ]
        },
        {
            "id": "task1447-cf83151b359d47dabaac4f98f57b9774",
            "input": "Self-limited edema is a well-recognized complication of insulin therapy.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-37cd9547bcdb460c91e2e3657e43fdca",
            "input": "This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-9b32e14536724d57a54cc4db0d792d7a",
            "input": "A case of pyridoxine-dependent seizures is reported.",
            "output": [
                "pyridoxine"
            ]
        },
        {
            "id": "task1447-d9aed14b1d024316b034c3935e1c7103",
            "input": "Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.",
            "output": [
                "pyridoxine"
            ]
        },
        {
            "id": "task1447-c11e64cdfec74fe3bfde7cae87321103",
            "input": "Prolonged severe cholestasis induced by oxacillin derivatives.",
            "output": [
                "oxacillin"
            ]
        },
        {
            "id": "task1447-4d9164405f95437b97ed36bc019e4df2",
            "input": "Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.",
            "output": [
                "oxacillin"
            ]
        },
        {
            "id": "task1447-378ffe0dd1544c7a90683ba1485e77b0",
            "input": "In all the patients, pellagra symptoms appeared during isoniazid therapy.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-2e752636f39049eb926e4777ad0fc684",
            "input": "Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.",
            "output": [
                "Isoniazid"
            ]
        },
        {
            "id": "task1447-7caf6fecb5bf45ffa545af4fb23a0b01",
            "input": "Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-fd6ef39911fc4951875f865c39b222e3",
            "input": "Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-db7bb940a2d94e7ea47c047a81e86afa",
            "input": "Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-50683971de204025809a21ebaf3a4984",
            "input": "These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-79691b5b8df448779d647c795450c1ba",
            "input": "A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-cf15a1bdffd040f1bc12f755a230ce3b",
            "input": "Amiodarone-induced dysthyroidism.",
            "output": [
                "Amiodarone"
            ]
        },
        {
            "id": "task1447-11a7fd2004204ac39bbf407e47cfb736",
            "input": "Propranolol-induced hypertension in treatment of cocaine intoxication.",
            "output": [
                "Propranolol"
            ]
        },
        {
            "id": "task1447-86d9c42ec03b40b6b6a23680f04091f0",
            "input": "According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-bb840250114041508a47864e50595033",
            "input": "Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.",
            "output": [
                "Chlorambucil"
            ]
        },
        {
            "id": "task1447-54bc18194077469a9b546c35d6610d4c",
            "input": "EEG abnormalities were observed in two of the nine children during chlorambucil therapy.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-283baaf394094b0ca3082f762978f201",
            "input": "A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.",
            "output": [
                "fenclofenac"
            ]
        },
        {
            "id": "task1447-3677316632744bd3a85ddb7722a26bb7",
            "input": "Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.",
            "output": [
                "Fenclofenac"
            ]
        },
        {
            "id": "task1447-d4fb06f332794d2bbe4530a0da4c7cd1",
            "input": "Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-bc0aedc8429141f68f2f162d918391d2",
            "input": "The elicitation of a movement disorder by trazodone: case report.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-fba67bea111845f9bceb055486029473",
            "input": "When the trazodone was reduced, the involuntary movements promptly ceased.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-d77651d7e11145a3b32a65ca2d4d4c76",
            "input": "A review of the literature showed no previous description of this pattern in benzodiazepine coma.",
            "output": [
                "benzodiazepine"
            ]
        },
        {
            "id": "task1447-fb1e554349104685aef6cb3bb61d5de4",
            "input": "Spindle coma in benzodiazepine toxicity: case report.",
            "output": [
                "benzodiazepine"
            ]
        },
        {
            "id": "task1447-6c4fbafcae1541bcab3fc3233fd86dbc",
            "input": "Two reports of spindle coma are noted with alcohol and imipramine.",
            "output": [
                "imipramine"
            ]
        },
        {
            "id": "task1447-05bde96175544894b167fddfe97254ee",
            "input": "A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-e2ed17bc9a384f12971422cad8c5944c",
            "input": "Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-d8a44a086d18431ab566937548a9e8c4",
            "input": "Rifampicin-induced renal failure.",
            "output": [
                "Rifampicin"
            ]
        },
        {
            "id": "task1447-f63222f137e74f2cb7fbafe750e3553c",
            "input": "The following is a report of 2 cases of rifampicin-induced renal insufficiency.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-c0559f37573f482b8e4e5711625c5493",
            "input": "Cerebral and ocular toxicity induced by desferrioxamine.",
            "output": [
                "desferrioxamine"
            ]
        },
        {
            "id": "task1447-7ea7e18686f243c587e0c425877f477c",
            "input": "Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.",
            "output": [
                "prochlorperazine"
            ]
        },
        {
            "id": "task1447-1475be2b77394ca2a5b6d3a6ada53c50",
            "input": "Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.",
            "output": [
                "desferrioxamine"
            ]
        },
        {
            "id": "task1447-ffa910e0356845329e919ebcbed96f01",
            "input": "Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.",
            "output": [
                "Gold"
            ]
        },
        {
            "id": "task1447-10692384cd9a4896b52406abbaa3c1fb",
            "input": "Three patients developed proteinuria following gold therapy for rheumatoid arthritis.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-4caae9bda584444c99b48ebe97c426e6",
            "input": "Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).",
            "output": [
                "Intralipid"
            ]
        },
        {
            "id": "task1447-3fe8da7cc3cc4c8786f7eb828caa6f38",
            "input": "In all three cases, autopsy revealed gross and microscopic features indistinguishable from those seen in the Hamman-Rich syndrome, and methotrexate hepatotoxicity was present in one.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-c2475c901d62473eb6b61f92eebaa30a",
            "input": "It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-d5a3888791564bdd9a267e91c278e9db",
            "input": "Methotrexate-induced diffuse interstitial pulmonary fibrosis.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-68fc3e868f8948b99e7057c9ba6e59d9",
            "input": "Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-0ebf478b02b846828c76cd6d8d26811a",
            "input": "Inappropriate antidiuretic hormone following adenine arabinoside administration.",
            "output": [
                "adenine arabinoside"
            ]
        },
        {
            "id": "task1447-94b35517cb9f42f2ae0038e273ee876e",
            "input": "Dystonia associated with carbamazepine administration: experience in brain-damaged children.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-fea58defd48d49fe82149bc2cafc73a8",
            "input": "In one child, a second course of carbamazepine resulted in a return of the dystonia.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-e8919cdcfc2840ce986ffd81f3587274",
            "input": "The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-12b90626a66647ff97eed617d7630845",
            "input": "Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-aaa987831ee347689c148a50d39a7e12",
            "input": "We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.",
            "output": [
                "5-FU"
            ]
        },
        {
            "id": "task1447-5625173c1b8543d39d234a601a2fa308",
            "input": "Lower extremity arterial insufficiency after long-term methysergide maleate therapy.",
            "output": [
                "methysergide maleate"
            ]
        },
        {
            "id": "task1447-58ec2c3b7f934d3db4fc65c2c462b4ee",
            "input": "The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.",
            "output": [
                "methysergide"
            ]
        },
        {
            "id": "task1447-a17ad927a6aa4e538bba8c43233fdcf6",
            "input": "A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.",
            "output": [
                "Rifampicin"
            ]
        },
        {
            "id": "task1447-aa512edc0f7f4fc0a3a54be8b62d88da",
            "input": "Erythema multiforme bullosum due to rifampicin.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-b13ed84b47e542f881ecfa51dd6a9f28",
            "input": "Renal damage associated with long term use of lithium carbonate.",
            "output": [
                "lithium carbonate"
            ]
        },
        {
            "id": "task1447-8c7c872e573941c79bb93f1125fa55fb",
            "input": "The authors report 2 cases of renal damage associated with lithium carbonate treatment.",
            "output": [
                "lithium carbonate"
            ]
        },
        {
            "id": "task1447-8caa6fc7d2b3416c89f3c4046d67ff83",
            "input": "In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).",
            "output": [
                "psoralens"
            ]
        },
        {
            "id": "task1447-62762e653a5f4d38b5a94cdb4e2b1d92",
            "input": "An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-d62d6f0380f64fc69068a07dd929e874",
            "input": "Severe acidosis from acetazolamide in a diabetic patient.",
            "output": [
                "acetazolamide"
            ]
        },
        {
            "id": "task1447-0165c5981a474d73a83f2ad2fb20eb7b",
            "input": "This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-240466b95bef4979aa0ca3747555ec3b",
            "input": "Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.",
            "output": [
                "clindamycin"
            ]
        },
        {
            "id": "task1447-3101e51b5a9d4e4fb0640fc360dcae6e",
            "input": "An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.",
            "output": [
                "Bromocryptine"
            ]
        },
        {
            "id": "task1447-311e76b504db4f098685b375cd02a40b",
            "input": "Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.",
            "output": [
                "formalin"
            ]
        },
        {
            "id": "task1447-25680469164d4f1a8203cfca551bbf0b",
            "input": "Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.",
            "output": [
                "formalin"
            ]
        },
        {
            "id": "task1447-a61e5c512e8f4e9bbc4c4e9a3cfd326f",
            "input": "Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.",
            "output": [
                "formic acid"
            ]
        },
        {
            "id": "task1447-884d682fe9d842d1a6714ed0bfd440ea",
            "input": "A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-addceb9eebc9428c9b0776f2dd1ae5bb",
            "input": "Edema associated with ibuprofen therapy.",
            "output": [
                "ibuprofen"
            ]
        },
        {
            "id": "task1447-1de943f82c984f96b67742cc5440506e",
            "input": "Allopurinol-associated hand and foot deformities in chronic tophaceous gout.",
            "output": [
                "Allopurinol"
            ]
        },
        {
            "id": "task1447-3c510435d46a48228698e0eeb63c3eb5",
            "input": "Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.",
            "output": [
                "allopurinol"
            ]
        },
        {
            "id": "task1447-38282723dc4045cc9e728d65d839f93b",
            "input": "Neurotoxicity of intrathecal administration of amphotericin B.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-1824f1468f5a4d838aa17cedf32f3ae3",
            "input": "In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.",
            "output": [
                "Bleomycin"
            ]
        },
        {
            "id": "task1447-ee4c093d744b4cd3ab9a2f5d73ef3d68",
            "input": "Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-44c5216cf4d94e1e9858ddc4c83b3472",
            "input": "Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.",
            "output": [
                "Doxorubicin"
            ]
        },
        {
            "id": "task1447-b71e2d3a89df451a90d4da80aafe92b2",
            "input": "Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.",
            "output": [
                "ouabain"
            ]
        },
        {
            "id": "task1447-54dc9557f1d944b68bfce00be9cead93",
            "input": "One other patient on digoxin stopped taking it and developed cardiomyopathy.",
            "output": [
                "digoxin"
            ]
        },
        {
            "id": "task1447-6307260d4ff74ea29687648189f5ca8c",
            "input": "One patient on ouabain also developed cardiomyopathy.",
            "output": [
                "ouabain"
            ]
        },
        {
            "id": "task1447-0c666d6da34e486ba06909baaa4c3e3a",
            "input": "A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.",
            "output": [
                "sulindac"
            ]
        },
        {
            "id": "task1447-cd45d086fc234794b144f14222236a3d",
            "input": "In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h.",
            "output": [
                "serine"
            ]
        },
        {
            "id": "task1447-83d0a243611d4dc7a21081ba8e3c2686",
            "input": "Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.",
            "output": [
                "ergotamine"
            ]
        },
        {
            "id": "task1447-1dd246afaf8b443893924e77506f55a0",
            "input": "Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.",
            "output": [
                "Chlorambucil"
            ]
        },
        {
            "id": "task1447-78f6049aa80c4782a658f75f6ce571c3",
            "input": "Anaphylactoid reaction to 50% solution of dextrose.",
            "output": [
                "dextrose"
            ]
        },
        {
            "id": "task1447-27a0262f44a74135ba8676c1ef5e7bec",
            "input": "Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.",
            "output": [
                "dextrose"
            ]
        },
        {
            "id": "task1447-0796002190e541758335377bcf019820",
            "input": "Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.",
            "output": [
                "dextrose"
            ]
        },
        {
            "id": "task1447-8e1569eda6cd44e0a635ab018e1fb83a",
            "input": "Salicylate hepato toxicity in rheumatic fever.",
            "output": [
                "Salicylate"
            ]
        },
        {
            "id": "task1447-6c84f71ee760459480eaeb6827dbee5b",
            "input": "Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-b3730498be7e449d9f0a390625a33e5e",
            "input": "Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-2cdacf25c96e464aa31d034f00ca55c4",
            "input": "Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-818a375424ee437cb89ee2f8b5caf705",
            "input": "The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-616b67a31d7b4241a53a003a4d0dca22",
            "input": "There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.",
            "output": [
                "Accutane"
            ]
        },
        {
            "id": "task1447-77b1a29346ae4dd680301f8c7e00e409",
            "input": "Allergic contact dermatitis to compound tincture of benzoin.",
            "output": [
                "benzoin"
            ]
        },
        {
            "id": "task1447-60a70d24aa754a69a150bcc6592db15e",
            "input": "Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.",
            "output": [
                "benzoin"
            ]
        },
        {
            "id": "task1447-f44ec29a573f45418b40ecb4f9aabbf3",
            "input": "In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.",
            "output": [
                "cytarabine"
            ]
        },
        {
            "id": "task1447-62c31e10ca58462ca8c32414c486a931",
            "input": "Visceral herpesvirus infections in leukemic patients receiving cytarabine.",
            "output": [
                "cytarabine"
            ]
        },
        {
            "id": "task1447-e3b3c74ef54a4c0b8e94e34c78b000b8",
            "input": "Clinical and morphological features of gold neuropathy.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-bfdc3543947c46beb3678dfdee832f83",
            "input": "Three cases of gold-related neuropathy are reported.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-8f9a27b302c84268a1d0ebf083439116",
            "input": "One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.",
            "output": [
                "clofazimine"
            ]
        },
        {
            "id": "task1447-8596c04c33334f2faf104ed643fdaea4",
            "input": "Severe neurotoxicity with methyl G: CALGB experience.",
            "output": [
                "methyl G: CALGB"
            ]
        },
        {
            "id": "task1447-a84afe384c3847fe8691e0f02a631464",
            "input": "A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.",
            "output": [
                "nortriptyline"
            ]
        },
        {
            "id": "task1447-a8537d4647b44e33a5ef02fcc842b665",
            "input": "Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.",
            "output": [
                "nortriptyline"
            ]
        },
        {
            "id": "task1447-8688a18e008647399db1620c30b32f01",
            "input": "It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.",
            "output": [
                "ACTH"
            ]
        },
        {
            "id": "task1447-96ff557aca0a467cb347a7b855ad683a",
            "input": "Disulfiram-like reactions with newer cephalosporins: cefmenoxime.",
            "output": [
                "cefmenoxime"
            ]
        },
        {
            "id": "task1447-d181b077cf3d42188daec61e3da56db4",
            "input": "This is the first report of a disulfiram-like reaction with cefmenoxime.",
            "output": [
                "cefmenoxime"
            ]
        },
        {
            "id": "task1447-d060386a061b402b84a27176b1e858bf",
            "input": "Acute leukopenia associated with silver sulfadiazine therapy.",
            "output": [
                "silver sulfadiazine"
            ]
        },
        {
            "id": "task1447-9da6f49289fa47da9813b61b56ca2d0b",
            "input": "Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-e8a2a9eff8d04eb687f000e9d8d06ba5",
            "input": "Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-446fe3c37d7c4433963df63b37e3e9b8",
            "input": "In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-0bd96f8c345742e5b0817fd847541be8",
            "input": "Nonoliguric acute renal failure after captopril therapy.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-d08567d4bf04436e8d5234c5556dad2f",
            "input": "Captopril-induced acute reversible renal failure.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-0960b5bc818a4fe09decdae47235be77",
            "input": "The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-d45c331f61654b15bee563ea9d1113be",
            "input": "We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-46938c418c144deaaa7c41ae244cf885",
            "input": "A case of mania associated with fluoxetine.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-364850d68fa54509b3fb1c96a8d57ac4",
            "input": "A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-3d2848fd70c04f33a02ecf193875e8e8",
            "input": "Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.",
            "output": [
                "25-hydroxyvitain D3"
            ]
        },
        {
            "id": "task1447-4f71e9aa643848b995cebc9a1d697d17",
            "input": "Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.",
            "output": [
                "cholestyramine"
            ]
        },
        {
            "id": "task1447-b54fec369cc74b1bb467827e3b1a1af0",
            "input": "Treatment of lithium tremor with metoprolol.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-84e1bb33498a42aeb3d8a5c0580ff4c9",
            "input": "Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.",
            "output": [
                "lithium carbonate"
            ]
        },
        {
            "id": "task1447-a0e218edfa1540fea420d999950a64d2",
            "input": "Intravenous diazepam exacerbated the seizures.",
            "output": [
                "diazepam"
            ]
        },
        {
            "id": "task1447-d6a23d83a82b41e9b3f6ab7a3b2ff802",
            "input": "A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-17da9d6f539a4b83821ee5f61c748251",
            "input": "A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-189d6100b7d9494d9af4d138fe8ce42e",
            "input": "Transient hemiparesis caused by phenytoin toxicity.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-b961235d21ee4cbdababe615a5077480",
            "input": "Cefoxitin therapy for Mycobacterium fortuitum bacteremia with associated granulomatous hepatitis.",
            "output": [
                "Cefoxitin"
            ]
        },
        {
            "id": "task1447-0858deb7a544443da1b4b8fa894f1b1e",
            "input": "Vasomotor reactions after gold sodium thiomalate are well recognized.",
            "output": [
                "gold sodium thiomalate"
            ]
        },
        {
            "id": "task1447-58f6effbb2974a37a18447b429befeac",
            "input": "Pulmonary gold toxicity.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-2a4b99a6349f41c58c2234fa69982eaf",
            "input": "Cyclophosphamide pneumonitis.",
            "output": [
                "Cyclophosphamide"
            ]
        },
        {
            "id": "task1447-2053c14481ea437ab4fbece7f99af372",
            "input": "A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-ef14b7c31c3e461ca9aa4f0123c869b2",
            "input": "Toxic hepatitis induced by disulfiram in a non-alcoholic.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-b29bf01e18cc40d290c329e56e368c3d",
            "input": "Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-1b1d8fae369c441dbfeafdbc1b919828",
            "input": "Tamoxifen retinopathy.",
            "output": [
                "Tamoxifen"
            ]
        },
        {
            "id": "task1447-83c7a95a91c24f0eaee813417e831aa7",
            "input": "These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-cca04ca788ec4eccbce4dcc628c81d1a",
            "input": "Mammary gigantism is a rare complication of D-penicillamine treatment.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-ed5f53f77134402a8c3456edb9833d97",
            "input": "Ampicillin-associated seizures.",
            "output": [
                "Ampicillin"
            ]
        },
        {
            "id": "task1447-9f50ef6720a94bfea14d3df9acdb05d5",
            "input": "Two patients had ampicillin-associated seizures.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-7fa5168b32534443935cf4d9146bbb7d",
            "input": "After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-d9f2dbbd982d4a1095c0f910ee49b800",
            "input": "Pemphigus foliaceus induced by rifampicin.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-710e69d0268c4e6792827fc63679de8c",
            "input": "Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.",
            "output": [
                "rifampicin"
            ]
        },
        {
            "id": "task1447-eecc909fca434c6ba6652ab0c89cbcdd",
            "input": "Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.",
            "output": [
                "lorcainide"
            ]
        },
        {
            "id": "task1447-40cdf699e5494f1e97e2b4d61e9805e0",
            "input": "In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.",
            "output": [
                "lorcainide"
            ]
        },
        {
            "id": "task1447-55b793d355474ec7a9876c106506541f",
            "input": "It is concluded that SIADH is an important side effect of lorcainide therapy.",
            "output": [
                "lorcainide"
            ]
        },
        {
            "id": "task1447-3e24dc554529417dae12424498d39d8f",
            "input": "One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.",
            "output": [
                "hydrochlorothiazide"
            ]
        },
        {
            "id": "task1447-a7d8fda9ac9f43f7a4074bd4ebe9967a",
            "input": "Chlorpropamide-induced hemolytic anemia.",
            "output": [
                "Chlorpropamide"
            ]
        },
        {
            "id": "task1447-6b31c083b02544f983bddbfdf1b639bb",
            "input": "In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-663088ccd1834a5a8a56c28d833d68a4",
            "input": "Interstitial pneumopathy and low-dosage amiodarone.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-4fd9e0919941416b9e34763f10492f59",
            "input": "The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-2171e56e7b134a3b8580e61ba14a9ad3",
            "input": "This was accepted as evidence for propranolol being the cause of this conduction disorder.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-48c3d0b0009947aebc839cfe94ee244e",
            "input": "A further case of anaphylactoid reaction to methylprednisolone is reported.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-be41a792a39245a280b964eea43d3c89",
            "input": "Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.",
            "output": [
                "methylprednisolone"
            ]
        },
        {
            "id": "task1447-908923d5ebc748c19d05377b3acd6962",
            "input": "Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.",
            "output": [
                "CCNU"
            ]
        },
        {
            "id": "task1447-7af5fa522949450ea4848287d469541c",
            "input": "Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.",
            "output": [
                "CCNU"
            ]
        },
        {
            "id": "task1447-f5cce9ee42aa4d6f9c716297e8a3e375",
            "input": "The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.",
            "output": [
                "CCNU"
            ]
        },
        {
            "id": "task1447-091ffcdc3ce4420ea364651f2157fe81",
            "input": "Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.",
            "output": [
                "CCNU"
            ]
        },
        {
            "id": "task1447-953c26947d3a42699f460828b72b1c42",
            "input": "Cholestyramine induced hyperchloremic metabolic acidosis.",
            "output": [
                "Cholestyramine"
            ]
        },
        {
            "id": "task1447-724865473e964170821ace2307d0c2f6",
            "input": "It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.",
            "output": [
                "cholestyramine"
            ]
        },
        {
            "id": "task1447-bdb0037135644d439ae7bec8e7cac034",
            "input": "The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.",
            "output": [
                "cholestyramine"
            ]
        },
        {
            "id": "task1447-2e72db9493e24feba066efc73164b951",
            "input": "A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-0fccffb160ee490090b844d3f3725b88",
            "input": "Amphotericin B nephrotoxicity in humans decreased by salt repletion.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-780fd41393c8488cb4a8726c2ab31381",
            "input": "Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-9da39ba0e224490f93d721fd83097a4f",
            "input": "Case report of withdrawal dyskinesia associated with amoxapine.",
            "output": [
                "amoxapine"
            ]
        },
        {
            "id": "task1447-4ef428c213f6469ebeb02d3753ec4a55",
            "input": "Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.",
            "output": [
                "amoxapine"
            ]
        },
        {
            "id": "task1447-b8dcb39f51a842d69cbf86b9017b6164",
            "input": "The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.",
            "output": [
                "amoxapine"
            ]
        },
        {
            "id": "task1447-11c80c273cec4676abb35aea0daa629f",
            "input": "Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.",
            "output": [
                "hydrochlorothiazide"
            ]
        },
        {
            "id": "task1447-75eae0ff8bcc4eacbad2c523cf3cae15",
            "input": "A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).",
            "output": [
                "scopolamine"
            ]
        },
        {
            "id": "task1447-ffd4f7c5600a462dbeec9761c755fc77",
            "input": "A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.",
            "output": [
                "deanol"
            ]
        },
        {
            "id": "task1447-9a51fead22134d09b1fa6a72c1ec06e6",
            "input": "Cephalosporins are most likely associated with Vitamin K deficiency.",
            "output": [
                "Cephalosporins"
            ]
        },
        {
            "id": "task1447-8f91013735c44e8fb897e5d7dfe455bb",
            "input": "Moxalactam is more likely to be associated with platelet dysfunction.",
            "output": [
                "Moxalactam"
            ]
        },
        {
            "id": "task1447-8d3300c3a56e4d638e1159e28bfb95e9",
            "input": "Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.",
            "output": [
                "cephalosporin"
            ]
        },
        {
            "id": "task1447-623df194574b4586aebde518e203664c",
            "input": "A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.",
            "output": [
                "BCNU"
            ]
        },
        {
            "id": "task1447-6f269dbde7854a54babd631b13423a7c",
            "input": "Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-cb0b073a9254407d8a8b6f62ace309ff",
            "input": "To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-083bdd6549f24670879bc4c12fce2806",
            "input": "Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-a7bd347e57dd4ec490311d974ac7d4ff",
            "input": "To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-74a69f14ab5449cf954b48cfe72bc7de",
            "input": "We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-6c9c6fac09ce4cd9a31f5bbc11aff321",
            "input": "A 61 year-old male patient developed gynecomastia after starting theophylline.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-7a4ceb20100c489abbf7eaa41da214fa",
            "input": "Gynecomastia associated with theophylline.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-7d9b847942514046a30abae41fab7f8f",
            "input": "No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-9d9c44ded83c4e11b4d0283d655943e5",
            "input": "The gynecomastia regressed when the theophylline was discontinued.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-aa271577d023449ab2f17db700fcc1e8",
            "input": "Parenteral-verapamil-induced sustained hypotension.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-9d0b079229e246ae830e70a3f72d6f62",
            "input": "The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-dcad5239973442c283857e8eb358600e",
            "input": "We report a case of sustained hypotension after administration of parenteral verapamil.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-5b3b173f25eb43debe40bde1ec519eea",
            "input": "A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.",
            "output": [
                "fenoprofen"
            ]
        },
        {
            "id": "task1447-e0dcc03f8a8a475e857cb1912ab0cca7",
            "input": "Pure red cell aplasia associated with fenoprofen.",
            "output": [
                "fenoprofen"
            ]
        },
        {
            "id": "task1447-e89c66502bd34870bb5bf02e2beb4889",
            "input": "This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.",
            "output": [
                "fenoprofen"
            ]
        },
        {
            "id": "task1447-f429170417db4fab8d43adf05ff48f7d",
            "input": "Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.",
            "output": [
                "quinacrine hydrochloride"
            ]
        },
        {
            "id": "task1447-3f9e948a1e2944a7aaa3be3d1acaf410",
            "input": "A case of priapism associated with trazodone is described.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-faa688d5e6c9406c9508972ac2aef8a7",
            "input": "Priapism associated with trazodone therapy: case report.",
            "output": [
                "trazodone"
            ]
        },
        {
            "id": "task1447-b461e0c5e733452fb8dfea46bc7ce4a7",
            "input": "Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.",
            "output": [
                "paracetamol"
            ]
        },
        {
            "id": "task1447-82fada0da36148e4a78ef573b9715d2d",
            "input": "Focal renal cortical necrosis associated with zomepirac.",
            "output": [
                "zomepirac"
            ]
        },
        {
            "id": "task1447-ed7557d57cf44802b56231a39714ff5f",
            "input": "The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.",
            "output": [
                "zomepirac"
            ]
        },
        {
            "id": "task1447-089983df11c840d8a25f6984176aa375",
            "input": "Cimetidine-induced fever.",
            "output": [
                "Cimetidine"
            ]
        },
        {
            "id": "task1447-9cff9b98a9a24279bb1f7a41d30b3963",
            "input": "Cimetidine is a rare cause of drug-induced fever.",
            "output": [
                "Cimetidine"
            ]
        },
        {
            "id": "task1447-21911a3aedd341b79f66f813b313de1c",
            "input": "A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.",
            "output": [
                "cinepazide"
            ]
        },
        {
            "id": "task1447-b66055af5aac45638b215334f0b391b5",
            "input": "Unique behavioral change with cinepazide in parkinsonism.",
            "output": [
                "cinepazide"
            ]
        },
        {
            "id": "task1447-580f09f1496b47d4bfb6680efea8f9b9",
            "input": "A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.",
            "output": [
                "Amphojel"
            ]
        },
        {
            "id": "task1447-39d011074254468e8944059f7e74a34f",
            "input": "A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-1a857e7202fc44f8bd011c62486830c1",
            "input": "Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.",
            "output": [
                "gold-salt"
            ]
        },
        {
            "id": "task1447-e919cca8247647239be750e1c64dbad1",
            "input": "Gold nephropathy.",
            "output": [
                "Gold"
            ]
        },
        {
            "id": "task1447-811d529cbf954801be84d80b2d6fe63a",
            "input": "Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.",
            "output": [
                "Gold-salt"
            ]
        },
        {
            "id": "task1447-bc092382e53446b8b513b6610d7a5717",
            "input": "The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-e71ea6c88a654895b1450a76468b36aa",
            "input": "These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.",
            "output": [
                "chlorpropamide"
            ]
        },
        {
            "id": "task1447-b27fca1e8ef647598e32b6db7dc4058e",
            "input": "In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",
            "output": [
                "ergonovine"
            ]
        },
        {
            "id": "task1447-b53b4134039d4e74ac417f17915f4f16",
            "input": "Catatonia associated with disulfiram therapy.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-bbcea5cc66ef43d69212b6624c97b5d0",
            "input": "Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-7d76e97d7b5242338e0173aa8a332964",
            "input": "This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-8352baa92f364395961d812dce090e87",
            "input": "Hepatic reactions to cyclofenil.",
            "output": [
                "cyclofenil"
            ]
        },
        {
            "id": "task1447-fef25c7c4e484cf3b92d942ab4fb75d4",
            "input": "Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.",
            "output": [
                "cyclofenil"
            ]
        },
        {
            "id": "task1447-b4b78154455947ccbccd50acf9f6bdc1",
            "input": "Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.",
            "output": [
                "theophylline"
            ]
        },
        {
            "id": "task1447-8cd95c9feaab4d89aa1f3a26238ed44e",
            "input": "A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.",
            "output": [
                "desipramine"
            ]
        },
        {
            "id": "task1447-5a7c02df84484c52a7e868087301067e",
            "input": "Desipramine-associated SIADH in an elderly woman: case report.",
            "output": [
                "Desipramine"
            ]
        },
        {
            "id": "task1447-3405e1636ac54886bcdf78e29492ac36",
            "input": "Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.",
            "output": [
                "rifampin"
            ]
        },
        {
            "id": "task1447-76d05cd9a95a4f5497df5569f8019e11",
            "input": "The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.",
            "output": [
                "rifampin"
            ]
        },
        {
            "id": "task1447-1f290e41a45b4429be4942b93d95e50c",
            "input": "Nephrotic range pseudoproteinuria in a tolmetin-treated patient.",
            "output": [
                "tolmetin"
            ]
        },
        {
            "id": "task1447-609658b947ec4aea971e5415fc5bc9c4",
            "input": "When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-e9bbf2ef080a48f7a3618f7ffdc33945",
            "input": "Fulminant hepatitis associated with disulfiram.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-83d85598202a4308abab71aaffb7ae0b",
            "input": "We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-cbd123eeade24044a2cee1692d84f898",
            "input": "A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-a1bb4eba02e747178bcf0903d4ce22d4",
            "input": "The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.",
            "output": [
                "methimazole"
            ]
        },
        {
            "id": "task1447-78d9bfa8200b473e82b309788831b61b",
            "input": "The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.",
            "output": [
                "asparaginase"
            ]
        },
        {
            "id": "task1447-dd74ac841d814977b43213034f9e037e",
            "input": "Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-a86d5ff11d7048db95749ec464a83560",
            "input": "Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-cbc8f84b16fd4ab6b8f6468209a8a40e",
            "input": "However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-1a52475d3eab4f0baeac83ab82e4e2f8",
            "input": "Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.",
            "output": [
                "disopyramide"
            ]
        },
        {
            "id": "task1447-43c5a7fd1d804e18b3db50ab5ea21a34",
            "input": "Cefoxitin-associated renal failure.",
            "output": [
                "Cefoxitin"
            ]
        },
        {
            "id": "task1447-9aac09d97a04415fbba87e5b176f7cc4",
            "input": "Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.",
            "output": [
                "cefoxitin sodium"
            ]
        },
        {
            "id": "task1447-5495f2f613804b98aae79f7d1c3ebbe8",
            "input": "Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.",
            "output": [
                "SQ 14225"
            ]
        },
        {
            "id": "task1447-136cb733e09f4531958f22576dd484df",
            "input": "Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.",
            "output": [
                "Amiodarone"
            ]
        },
        {
            "id": "task1447-fb46729f7e144a0f98a88d91bba55e82",
            "input": "Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.",
            "output": [
                "dopamine"
            ]
        },
        {
            "id": "task1447-db24d2ad219b4ef388f5f430cb721465",
            "input": "Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.",
            "output": [
                "hydroxychloroquine"
            ]
        },
        {
            "id": "task1447-faf3f258aef54e3195b5de1fb51408bd",
            "input": "Hepatitis following cimetidine administration.",
            "output": [
                "cimetidine"
            ]
        },
        {
            "id": "task1447-3bf1b0f9a6a24995996180cd803dd1a4",
            "input": "There have been only two reports of cimetidine-induced hepatitis.",
            "output": [
                "cimetidine"
            ]
        },
        {
            "id": "task1447-68803ba459104cc4b412f8de231c1def",
            "input": "A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.",
            "output": [
                "digoxin"
            ]
        },
        {
            "id": "task1447-dd60df2b3af14adbb25cb1250bb63fe8",
            "input": "Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.",
            "output": [
                "Verapamil"
            ]
        },
        {
            "id": "task1447-f2c25da602a346d6aa3a744840fcaec3",
            "input": "Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.",
            "output": [
                "Flucytosine"
            ]
        },
        {
            "id": "task1447-c9133558aac349768ff45c398bddaaf2",
            "input": "Ulcerating enteritis associated with flucytosine therapy.",
            "output": [
                "flucytosine"
            ]
        },
        {
            "id": "task1447-bd3248e784e444c39e772f96d00be739",
            "input": "Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.",
            "output": [
                "perhexiline maleate"
            ]
        },
        {
            "id": "task1447-5b1de368411a491fb3327eba01ea9bda",
            "input": "Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-3b3764be397e4f4ea8b4b44d8eee12c6",
            "input": "L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-3ba1d33e8bfd4848889439f6d792427f",
            "input": "Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.",
            "output": [
                "L-asparaginase"
            ]
        },
        {
            "id": "task1447-5e1523d915884a618d3bdc781c9f0f38",
            "input": "In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.",
            "output": [
                "DCA"
            ]
        },
        {
            "id": "task1447-0c12605e2ed04e88904a36a878598a8a",
            "input": "Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-fb1430bfe00947d9bf415af92eb2ae18",
            "input": "The course of delirium due to lithium intoxication.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-330132fc16624457a38cfa061f4f2553",
            "input": "Life-threatening hyperkalemia induced by arginine.",
            "output": [
                "arginine"
            ]
        },
        {
            "id": "task1447-efd9091352324bac8fa2dc4bd398132c",
            "input": "Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.",
            "output": [
                "arginine monohydrochloride"
            ]
        },
        {
            "id": "task1447-89d863642d6c451e940fb74f9f3c93f1",
            "input": "A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-71dbe91fc91744e88c0c9c03db2734e0",
            "input": "Acne provoked by gold seems not to have been described elsewhere.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-2ae877a645564d34b704ddd0dc330a29",
            "input": "The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-e86dd76d035044b5a113a6f10f8ad5cf",
            "input": "These results indicate that lithium may cause biochemical hyperparathyroidism.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-1c46a5a3320443a48fd49c5debbd0500",
            "input": "Disopyramide-induced heart block.",
            "output": [
                "Disopyramide"
            ]
        },
        {
            "id": "task1447-87b43b0f34f74f2183cf83d205c24fbd",
            "input": "In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.",
            "output": [
                "bretylium"
            ]
        },
        {
            "id": "task1447-804182fed71a4e34bc5f0b5ed5b023ea",
            "input": "Nephrotic syndrome associated with lithium therapy.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-49c7ccc90db44e83b24ac0c5d39803a2",
            "input": "Two patients on long-term lithium therapy developed the nephrotic syndrome.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-8213b32e406848949ab8038d65bf6885",
            "input": "A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-56a1b923a8234f7585886ee1b217f06a",
            "input": "A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-16fe6ef07df5481d8b36163354dd60b9",
            "input": "Acute acoustic nerve palsy associated with vincristine therapy.",
            "output": [
                "vincristine"
            ]
        },
        {
            "id": "task1447-fc7ab8054c5d49018700c171ff35748e",
            "input": "A case of timolol-associated heart failure in a 73-year old white man is reported.",
            "output": [
                "timolol"
            ]
        },
        {
            "id": "task1447-c9b67ae7ed344551b7f431cbc03b7606",
            "input": "Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.",
            "output": [
                "digoxin"
            ]
        },
        {
            "id": "task1447-decede94373e4434949abfd0615c7af9",
            "input": "Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.",
            "output": [
                "L-dopa"
            ]
        },
        {
            "id": "task1447-4033531f0fe84076816342c751e013da",
            "input": "The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.",
            "output": [
                "L-dopa"
            ]
        },
        {
            "id": "task1447-d2483ce10be54a0b8f523210aee8f447",
            "input": "Liver disease induced by perhexiline maleate.",
            "output": [
                "perhexiline maleate"
            ]
        },
        {
            "id": "task1447-596a1b53eb6643cba3f3e907b5cd527f",
            "input": "This paper reports a case of fatal perhexiline maleate liver injury.",
            "output": [
                "perhexiline maleate"
            ]
        },
        {
            "id": "task1447-912b910edf684264a2eb4e110953e319",
            "input": "Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.",
            "output": [
                "Treosulfan"
            ]
        },
        {
            "id": "task1447-2f29d37e8b6c4e50a1c78545184c871a",
            "input": "The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.",
            "output": [
                "Treosulfan"
            ]
        },
        {
            "id": "task1447-ea19d6a259d241b98f85dd0d0dcfb09e",
            "input": "Propranolol-related bronchospasm in patients without history of asthma.",
            "output": [
                "Propranolol"
            ]
        },
        {
            "id": "task1447-e22f834858d8465685f54c9778a4bc7a",
            "input": "Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-4c134fedc2cb4c7aa49aae4360cb5a51",
            "input": "Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-bcd9db27f11647f2802cd87c546d4941",
            "input": "Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.",
            "output": [
                "Propranolol"
            ]
        },
        {
            "id": "task1447-17a5129058d042a68c7d528c2edc1dd6",
            "input": "The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.",
            "output": [
                "propranolol"
            ]
        },
        {
            "id": "task1447-70497eb8204d4c2e9965b904e5ef6fbc",
            "input": "Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-2e06c554ad704632a4d0d46aa425e12e",
            "input": "Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-eefa99a6b2214a70a2afc0296bd05831",
            "input": "Progressive interstitial lung disease from prolonged methotrexate therapy.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-277164817a9e4c4fbd17c9ff575c2f87",
            "input": "Diagnosis: practolol induced sclerosing peritonitis.",
            "output": [
                "practolol"
            ]
        },
        {
            "id": "task1447-387416cec6924995b4baebb998ec7793",
            "input": "A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.",
            "output": [
                "niflumic acid"
            ]
        },
        {
            "id": "task1447-336f7e7976164c92adb1645944cca9c3",
            "input": "After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.",
            "output": [
                "niflumic acid"
            ]
        },
        {
            "id": "task1447-d0a1d60734c04527a79611743a090759",
            "input": "Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?",
            "output": [
                "Niflumic acid"
            ]
        },
        {
            "id": "task1447-d53644f8d42b43cbb8a848eb2a15f148",
            "input": "The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.",
            "output": [
                "niflumic acid"
            ]
        },
        {
            "id": "task1447-838d1283253b44a29607dcef815118a9",
            "input": "Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-9e99baff3a984f1bba584eeb9ffc44cd",
            "input": "These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-8caec9d42ff64167949a98b268d85342",
            "input": "Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.",
            "output": [
                "D-penicillamine"
            ]
        },
        {
            "id": "task1447-8545da9870a64faab23b21b9205a532b",
            "input": "A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.",
            "output": [
                "metformin"
            ]
        },
        {
            "id": "task1447-eb52e32367a8465484e9ce1f136b669c",
            "input": "Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.",
            "output": [
                "Para-aminosalicylic acid"
            ]
        },
        {
            "id": "task1447-9aa1b3d1e11c427db4633ee730d77ab4",
            "input": "The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.",
            "output": [
                "PAS"
            ]
        },
        {
            "id": "task1447-865b6b9361734eecb655457fab9b6a5a",
            "input": "Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-955da992adec48d4b89c526abc30b391",
            "input": "Unusual pigmentary changes associated with 5-fluorouracil therapy.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-8fa5bda8f7644761b4fc5b30ee8c1c1f",
            "input": "Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-f754602034694b4b8371a8e215fed7a7",
            "input": "The authors describe a case of the catatonia syndrome associated with disulfiram therapy.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-cacaf78b606a4341a1e4b61c53b2e938",
            "input": "Inappropriate antidiuretic hormone secretion after high dose vinblastine.",
            "output": [
                "vinblastine"
            ]
        },
        {
            "id": "task1447-32b12545d5b040f4a08f19a60498312f",
            "input": "We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.",
            "output": [
                "vinblastine"
            ]
        },
        {
            "id": "task1447-d96ba0afd0bc4c76a12e76f67b12e9f1",
            "input": "Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.",
            "output": [
                "emepronium bromide"
            ]
        },
        {
            "id": "task1447-e453949ce27741159a839719d646eba2",
            "input": "Oesophageal ulceration due to emepronium bromide.",
            "output": [
                "emepronium bromide"
            ]
        },
        {
            "id": "task1447-9d804c778aaf4a8b994223c5e4cd9ffb",
            "input": "Cardiorespiratory toxicity due to miconazole.",
            "output": [
                "miconazole"
            ]
        },
        {
            "id": "task1447-2b069379cfe24d5a805183336da5c8e6",
            "input": "None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-d4eea4e4bf854e5d975f01fba6002c73",
            "input": "Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.",
            "output": [
                "miconazole"
            ]
        },
        {
            "id": "task1447-59ff5cd3d6ae48569b44930298bc63d2",
            "input": "Clofibrate-induced myopathy in patients with diabetes insipidus.",
            "output": [
                "Clofibrate"
            ]
        },
        {
            "id": "task1447-6be183110457487cb385e3927b1f16aa",
            "input": "However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.",
            "output": [
                "clofibrate"
            ]
        },
        {
            "id": "task1447-f12224c4076b4fd9b4afaf8cc4c52c17",
            "input": "Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.",
            "output": [
                "clofibrate"
            ]
        },
        {
            "id": "task1447-63e6767cc0f545a7962d5d4510954918",
            "input": "Hepatotoxicity of hycanthone in patients with metastatic breast cancer.",
            "output": [
                "hycanthone"
            ]
        },
        {
            "id": "task1447-1070dc1ca79645f783dbf51a07191d66",
            "input": "In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.",
            "output": [
                "hycanthone"
            ]
        },
        {
            "id": "task1447-471492816c4a46418aec9a1d00cea4e8",
            "input": "Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-b2dbb9cf19d54cc0b61031ea6ba831ea",
            "input": "Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.",
            "output": [
                "chlorambucil"
            ]
        },
        {
            "id": "task1447-2ec3660203424fb7bdb2caa9d8cac1ec",
            "input": "A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.",
            "output": [
                "barbiturate"
            ]
        },
        {
            "id": "task1447-c6ec7702f7024a438a29ffab92985275",
            "input": "Barbiturate-induced submassive hepatic necrosis.",
            "output": [
                "Barbiturate"
            ]
        },
        {
            "id": "task1447-9703fde0bb424f3ab09ec6051fede80f",
            "input": "The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.",
            "output": [
                "barbiturates"
            ]
        },
        {
            "id": "task1447-693cf83dc6674440a709aa94f6672b8e",
            "input": "A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-2eedcad6f0bd4db392418c07ed602858",
            "input": "Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-ce3544b49de742119d423873302c088d",
            "input": "The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-7fe592fb3c0140a39bbf51b886a88ffb",
            "input": "We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.",
            "output": [
                "diphenylhydantoin"
            ]
        },
        {
            "id": "task1447-80d7f28f459e44ac9fef0d0bb9390203",
            "input": "CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.",
            "output": [
                "Atovaquone"
            ]
        },
        {
            "id": "task1447-a298224f4e294f54baf56c11874772ba",
            "input": "PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.",
            "output": [
                "atovaquone"
            ]
        },
        {
            "id": "task1447-2adfce8cca8d48d192709bd2b98268fb",
            "input": "Vortex keratopathy associated with atovaquone.",
            "output": [
                "atovaquone"
            ]
        },
        {
            "id": "task1447-c45413ba11ce458c9d8abeacc7a39cf2",
            "input": "A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.",
            "output": [
                "flecainide"
            ]
        },
        {
            "id": "task1447-b7656ee0d3e74270af5a4965acde2e37",
            "input": "Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.",
            "output": [
                "flecainide"
            ]
        },
        {
            "id": "task1447-8de7f16ba221454b8b9c0517695a0f95",
            "input": "Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-c31322732b884804bcd2d3b53453ba70",
            "input": "Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.",
            "output": [
                "Chlormadinone acetate"
            ]
        },
        {
            "id": "task1447-b22aa5644d54494782b41d4e13e11738",
            "input": "Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-7583c1e434824cff8ce274384cfdee35",
            "input": "The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.",
            "output": [
                "GSTM"
            ]
        },
        {
            "id": "task1447-b99b3b48af514a87840c400c171fb503",
            "input": "Acute sensorineural hearing loss following intravenous ketoralac administration.",
            "output": [
                "ketoralac"
            ]
        },
        {
            "id": "task1447-7370d325095746a88c3f8a2e66bfc0e0",
            "input": "We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.",
            "output": [
                "ketorolac"
            ]
        },
        {
            "id": "task1447-0a56f532a4d5482c8a81bb895057db37",
            "input": "We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.",
            "output": [
                "ketoralac"
            ]
        },
        {
            "id": "task1447-ebc5808f74954fdeadcf0b720981e8f2",
            "input": "Anaphylactoid reactions with intraperitoneal cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-9875172b71d84f6a818c9fd374e95469",
            "input": "CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-ce005988e4de4bd8be62b360e79714cd",
            "input": "CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-a773b991fc3943f4adcac8dccbab6378",
            "input": "DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-0bb546458b8d400287ce5d267f884d65",
            "input": "OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-ad7644c83c5243d29ddd54f76e0a3e33",
            "input": "We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-5db9a4eb083c477d98229864e39ec4fd",
            "input": "Etoposide-related myocardial infarction.",
            "output": [
                "Etoposide"
            ]
        },
        {
            "id": "task1447-fe233f7bc93e4558ba346629ef329a61",
            "input": "The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.",
            "output": [
                "etoposide"
            ]
        },
        {
            "id": "task1447-548701d09ab5482eb2be2044c9796242",
            "input": "A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-68c6f62a1d1545f5aad6743211cf117b",
            "input": "Acute renal failure in a child associated with acyclovir.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-2520673ab6d14b30a4898378d8ebb77f",
            "input": "Anterior ischemic optic neuropathy secondary to interferon alfa.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-85a95ad34444486dab3de920046effd7",
            "input": "CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-5b97e27f76bb4466b6967520046dbdaa",
            "input": "OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-3b0da132946e49b8b2e254c142cadf86",
            "input": "PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.",
            "output": [
                "interferon alfa"
            ]
        },
        {
            "id": "task1447-a0a13580d18549a3a496a378ebfaefce",
            "input": "CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.",
            "output": [
                "levothyroxine"
            ]
        },
        {
            "id": "task1447-f5ebd8a8bad0433ab13a4196e31b7b53",
            "input": "Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-a471a5cdd05845c7a31a9222dddbb200",
            "input": "Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-e087ad36d5e94a3b94c7e537c572265a",
            "input": "OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.",
            "output": [
                "propafenone"
            ]
        },
        {
            "id": "task1447-998e375d211b4ee1b56091c879cc6f37",
            "input": "Probable propafenone-induced transient global amnesia.",
            "output": [
                "propafenone"
            ]
        },
        {
            "id": "task1447-7ff4d34f18254639859783de3fb559f8",
            "input": "A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-d4309a2306e2426e94ba9f52f576abab",
            "input": "Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.",
            "output": [
                "aspirin"
            ]
        },
        {
            "id": "task1447-652b71c22c6046eea07f78a152b2b533",
            "input": "Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-735a4ad7a5224dba8052a16040c67b26",
            "input": "However, the occurrence and management of akathisia induced by fluvoxamine have not been described.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-56c0154e3bd64077b294c130ac5c49d1",
            "input": "In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.",
            "output": [
                "fluvoxamine"
            ]
        },
        {
            "id": "task1447-b6e6501cdb854c9b95e1d20580d0d4bf",
            "input": "A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-44fc47b2523c4c3d892b3764cf29c0d5",
            "input": "Severe bleomycin lung toxicity: reversal with high dose corticosteroids.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-3a33140de64f4a1891e72b3c941b05c1",
            "input": "This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.",
            "output": [
                "bleomycin"
            ]
        },
        {
            "id": "task1447-b34209851b1043cfbbff73ac0cded09a",
            "input": "Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-d0a1118b33314462b144676cd5c0ea9f",
            "input": "We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-f6a2f5ba10054ee9a738cdaee37e6272",
            "input": "Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-945cdf54388249c98d3ed719f6f185e9",
            "input": "I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).",
            "output": [
                "amphotericin"
            ]
        },
        {
            "id": "task1447-647bc159a9744e5fb4c52c44384288ba",
            "input": "This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.",
            "output": [
                "IFN"
            ]
        },
        {
            "id": "task1447-a1b61ea8ca654ed08310f82ed6234bb4",
            "input": "Acute isoniazid neurotoxicity in an urban hospital.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-02f1b468023a4393a81939463851ed42",
            "input": "CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.",
            "output": [
                "INH"
            ]
        },
        {
            "id": "task1447-a50a5316afa44612831f1929bd25446a",
            "input": "In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.",
            "output": [
                "INH"
            ]
        },
        {
            "id": "task1447-c54fec82007a44e784fdb9e4ce65b559",
            "input": "Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.",
            "output": [
                "INH"
            ]
        },
        {
            "id": "task1447-61cc1792a35a43eeb4874327da72c84c",
            "input": "RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.",
            "output": [
                "INH"
            ]
        },
        {
            "id": "task1447-98918cb0cc714aec82d4a6bb13a1429d",
            "input": "Arterial hypertension associated with topical ocular use of phenylephrine in dogs.",
            "output": [
                "phenylephrine"
            ]
        },
        {
            "id": "task1447-3b6338e4922b4a639ddb66eedb408335",
            "input": "CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.",
            "output": [
                "progestin"
            ]
        },
        {
            "id": "task1447-61947664c83f475aba239d5037ef5bf2",
            "input": "OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.",
            "output": [
                "progestin"
            ]
        },
        {
            "id": "task1447-05f5bb7ae4204d4394af89a753e9b144",
            "input": "RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.",
            "output": [
                "progestin"
            ]
        },
        {
            "id": "task1447-8f46335c7e2c4d4aa452a18c655a0c56",
            "input": "Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.",
            "output": [
                "furosemide"
            ]
        },
        {
            "id": "task1447-2af8a596f6894518a1a0216235177917",
            "input": "Furosemide-associated fever.",
            "output": [
                "Furosemide"
            ]
        },
        {
            "id": "task1447-8aad309f2ec34509aebdea95cf7e0fe0",
            "input": "The dose-limiting toxicity of KW-2149 is pulmonary toxicity.",
            "output": [
                "KW-2149"
            ]
        },
        {
            "id": "task1447-bea9cf9a076a4eddbafb910f3b44b770",
            "input": "Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-5f931ec6b6e846ee8927407960f03412",
            "input": "Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.",
            "output": [
                "benzarone"
            ]
        },
        {
            "id": "task1447-512ff4aa721343828d3ec5fd5ff8a1b0",
            "input": "We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.",
            "output": [
                "benzarone"
            ]
        },
        {
            "id": "task1447-c8d60422049b4b7dacdbf6b78d3f9a8c",
            "input": "Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.",
            "output": [
                "warfarin"
            ]
        },
        {
            "id": "task1447-6473619eb2274d7892ddae92ef8e4b70",
            "input": "Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.",
            "output": [
                "mefloquine"
            ]
        },
        {
            "id": "task1447-8a51de82cc5142a68137e782f8e90670",
            "input": "Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.",
            "output": [
                "mefloquine"
            ]
        },
        {
            "id": "task1447-8b0c25323c8f420881e441575142b234",
            "input": "Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.",
            "output": [
                "Mefloquine"
            ]
        },
        {
            "id": "task1447-31fb03b269f04bb08f9b082e1cf91fe0",
            "input": "We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.",
            "output": [
                "mefloquine"
            ]
        },
        {
            "id": "task1447-bef584ae718143598d0356859c02b9c0",
            "input": "Because sumatriptan can cause coronary artery vasospasm, patients with significant risk factors for coronary artery disease should be carefully evaluated for cardiovascular disease prior to the use of sumatriptan.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-6331b80e705d4e1ba0668c912fa11a20",
            "input": "Cardiac arrest following use of sumatriptan.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-d35c08d4e46d4e4f86028fb95aea1920",
            "input": "I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.",
            "output": [
                "sumatriptan"
            ]
        },
        {
            "id": "task1447-a5eff6cb7e52431f95a62ed5660000c2",
            "input": "Sotalol-induced bradycardia reversed by glucagon.",
            "output": [
                "Sotalol"
            ]
        },
        {
            "id": "task1447-9e62e236229b46fa9b109b37fd0d63ec",
            "input": "We present a case of sotalol-induced bradycardia reversed by glucagon.",
            "output": [
                "sotalol"
            ]
        },
        {
            "id": "task1447-81463f5f91e847d8a978c37abb484e33",
            "input": "Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-e8821b3af06a476296ddab0d598f83e3",
            "input": "We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-0b7235860a55470690b7bab6d06e7d2c",
            "input": "Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-d5f64c5cf7574f3abb2b9cf269065755",
            "input": "Esophageal candidiasis following omeprazole therapy: a report of two cases.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-1d7367e30b8f46d6ac1551e4b19684a6",
            "input": "Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.",
            "output": [
                "omeprazole"
            ]
        },
        {
            "id": "task1447-6cdc497689034ef8ad0c846e66d1db22",
            "input": "High-grade atrioventricular block during dipyridamole stress testing.",
            "output": [
                "dipyridamole"
            ]
        },
        {
            "id": "task1447-f3dcb6237faa41e385e341efeb3bd056",
            "input": "We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.",
            "output": [
                "dipyridamole"
            ]
        },
        {
            "id": "task1447-3d2881aad268412dbf1f011ebf05e3cc",
            "input": "There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.",
            "output": [
                "doxorubicin"
            ]
        },
        {
            "id": "task1447-054636aafb084a748e84720511e6a674",
            "input": "The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-6c9acddb98cf48e49969fdfa713b37c1",
            "input": "Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.",
            "output": [
                "levamisole"
            ]
        },
        {
            "id": "task1447-13c83e6264934ba298f26cf2017a8330",
            "input": "Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.",
            "output": [
                "levamisole"
            ]
        },
        {
            "id": "task1447-8b71e6cb5dcf425d818bd2da643c1128",
            "input": "A case of noncardiogenic pulmonary edema by ethanolamine oleate.",
            "output": [
                "ethanolamine oleate"
            ]
        },
        {
            "id": "task1447-7dbd88b872844447a758921793dfd447",
            "input": "However, EO-induced noncardiogenic pulmonary edema has not been reported in human.",
            "output": [
                "EO"
            ]
        },
        {
            "id": "task1447-a58a194b076b467297ad885cd5cc7725",
            "input": "We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.",
            "output": [
                "EO"
            ]
        },
        {
            "id": "task1447-27322c411e7f48a1805fee555ba3fe30",
            "input": "Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.",
            "output": [
                "gentamicin sulfate"
            ]
        },
        {
            "id": "task1447-e1da6cb06166417d87c845461ce892df",
            "input": "Gentamicin-associated acute renal failure.",
            "output": [
                "Gentamicin"
            ]
        },
        {
            "id": "task1447-fe4b473ba7514a2e830c6104e74ab458",
            "input": "Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.",
            "output": [
                "gentamicin"
            ]
        },
        {
            "id": "task1447-0c54490c7cb846baa44128e4b27ad8c9",
            "input": "A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-f003579e942547148dde2113395fb9a5",
            "input": "The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.",
            "output": [
                "albuterol"
            ]
        },
        {
            "id": "task1447-e482dcc997cb4890a9735c8896acf146",
            "input": "Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.",
            "output": [
                "Propoxyphene"
            ]
        },
        {
            "id": "task1447-bd5d5cb151fa40ac8437f5e4f6e3e147",
            "input": "Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.",
            "output": [
                "Propoxyphene"
            ]
        },
        {
            "id": "task1447-9b37cb19bb5e4e91b8ad04ef6dbf1996",
            "input": "Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.",
            "output": [
                "mannitol"
            ]
        },
        {
            "id": "task1447-cfdc5a3f98a34af38197a4508470383b",
            "input": "Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.",
            "output": [
                "mannitol"
            ]
        },
        {
            "id": "task1447-510feda1437c40d88b603b1e1b0fa63f",
            "input": "Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.",
            "output": [
                "Mannitol"
            ]
        },
        {
            "id": "task1447-add97cfc0a944ded9fe9c2050d9e3b54",
            "input": "This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.",
            "output": [
                "mannitol"
            ]
        },
        {
            "id": "task1447-125d77f5640646fdbcae2c31b34ccb13",
            "input": "Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.",
            "output": [
                "fluphenazine decanoate"
            ]
        },
        {
            "id": "task1447-18b754240bcb4821a73171f9d408e689",
            "input": "Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.",
            "output": [
                "benzodiazepine"
            ]
        },
        {
            "id": "task1447-a2388cb592fb463eadc18b694ec4ea60",
            "input": "CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.",
            "output": [
                "quinapril"
            ]
        },
        {
            "id": "task1447-91d7d76ff3744d52bb634297d0fb284c",
            "input": "Cough induced by quinapril with resolution after changing to fosinopril.",
            "output": [
                "quinapril"
            ]
        },
        {
            "id": "task1447-2e33bed7477d4f4b92088d1af8f2ceee",
            "input": "OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.",
            "output": [
                "quinapril"
            ]
        },
        {
            "id": "task1447-e7cf2c91349a42e6bd5a4b7c8685852a",
            "input": "The cough continued for the duration of therapy with quinapril.",
            "output": [
                "quinapril"
            ]
        },
        {
            "id": "task1447-d59927fab0fc4116b8d194d012ea7a23",
            "input": "We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.",
            "output": [
                "quinapril"
            ]
        },
        {
            "id": "task1447-407d1143f01944a1b5d8266ddba07285",
            "input": "Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",
            "output": [
                "PSL"
            ]
        },
        {
            "id": "task1447-9a965c68af914510ba505e5d39362da0",
            "input": "Cefuroxime-induced acute renal failure.",
            "output": [
                "Cefuroxime"
            ]
        },
        {
            "id": "task1447-be9b3b610f804a66827e8ca7a90e59dc",
            "input": "In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.",
            "output": [
                "cefuroxime"
            ]
        },
        {
            "id": "task1447-df51a445b2dd4f728c7155255ed67a47",
            "input": "The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.",
            "output": [
                "cefuroxime"
            ]
        },
        {
            "id": "task1447-6a9269471f734383ad62a9ae76410bdd",
            "input": "This is the first reported case of suspected DIAN due to cefuroxime.",
            "output": [
                "cefuroxime"
            ]
        },
        {
            "id": "task1447-75829b0612bf48abaa3904afc339f637",
            "input": "A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-2ce2db2453274385b101edf4a917d815",
            "input": "His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-e1a954a1eace40b6b5ef3ba2cbd495d8",
            "input": "Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-93073384b3854addbbd553c4ce7d9558",
            "input": "Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-2115851b8f56455c9fe0b0b50b501fe0",
            "input": "Acute pancreatitis associated with danazol treatment for endometriosis.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-cc1c8cb0a4254e9eb8c417aac5f1f850",
            "input": "Additionally, danazol produces hepatocellular damage in approximately 10% of women.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-8806cc5f79764e2f8a2189d0e311bfae",
            "input": "Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-c5d524fce79f400caae3cb6445ff4917",
            "input": "The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.",
            "output": [
                "danazol"
            ]
        },
        {
            "id": "task1447-274988905d2d47edb7989c83951b9caa",
            "input": "Acyclovir neurotoxicity: clinical experience and review of the literature.",
            "output": [
                "Acyclovir"
            ]
        },
        {
            "id": "task1447-3df54da286a34e8bbf2efae11cadb765",
            "input": "Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.",
            "output": [
                "Acyclovir"
            ]
        },
        {
            "id": "task1447-109034aa57844c7bb077142b725ab5ac",
            "input": "Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-ebacfefafbdd47a8a9d15df10ffbbede",
            "input": "We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-c75a60d950d44d9daa560ae1230772d2",
            "input": "Response of a promethazine-induced coma to flumazenil.",
            "output": [
                "promethazine"
            ]
        },
        {
            "id": "task1447-71004d3fde6544ef87463242532be224",
            "input": "We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.",
            "output": [
                "promethazine"
            ]
        },
        {
            "id": "task1447-1a5e7fdba8784d7f88deb15493a6a5bb",
            "input": "Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.",
            "output": [
                "Actinomycin D"
            ]
        },
        {
            "id": "task1447-71e2a447b7d54761a4ab78f0638831a3",
            "input": "There are now reports of liver failure following treatment of childhood cancers with AMD.",
            "output": [
                "AMD"
            ]
        },
        {
            "id": "task1447-f8329321026b48c99de9604b17576405",
            "input": "Phenylpropanolamine-induced psychosis.",
            "output": [
                "Phenylpropanolamine"
            ]
        },
        {
            "id": "task1447-6e9665f636a340ddac45df9ca239d134",
            "input": "CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.",
            "output": [
                "budesonide"
            ]
        },
        {
            "id": "task1447-d83943ac16d044b49a402dd23ba92668",
            "input": "Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.",
            "output": [
                "budesonide"
            ]
        },
        {
            "id": "task1447-5a20c7c609374e4db79586007c953779",
            "input": "METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.",
            "output": [
                "budesonide"
            ]
        },
        {
            "id": "task1447-79a0d6cfe04e45d4b8a0c873d3c85097",
            "input": "RESULTS: Budesonide use can cause contact dermatitis.",
            "output": [
                "Budesonide"
            ]
        },
        {
            "id": "task1447-d096920e37064116b7269ae1da4e47a3",
            "input": "Methemoglobinemia: an occupational hazard of phenylpropanolamine production.",
            "output": [
                "phenylpropanolamine"
            ]
        },
        {
            "id": "task1447-87a2ebb6d82e41c8952551869423576c",
            "input": "During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.",
            "output": [
                "IFN"
            ]
        },
        {
            "id": "task1447-7b40577e9fbf43a9ab3a47a0e7592f84",
            "input": "Occurrence of IDDM during interferon therapy for chronic viral hepatitis.",
            "output": [
                "interferon"
            ]
        },
        {
            "id": "task1447-4a219583061b40748657cad2c8f18bf7",
            "input": "We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.",
            "output": [
                "interferon"
            ]
        },
        {
            "id": "task1447-2d8b3b10ecd64a89b08d100119aba3f0",
            "input": "Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-16ae54e0ccf24ba9bc0770dbc2addd6b",
            "input": "This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.",
            "output": [
                "clindamycin"
            ]
        },
        {
            "id": "task1447-9bfbf6f384424e71ab5c8b72e8d99357",
            "input": "There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-10d264daa5944da9aebcffb813d4cbee",
            "input": "Toxic optic neuropathy associated with ethambutol: implications for current therapy.",
            "output": [
                "ethambutol"
            ]
        },
        {
            "id": "task1447-59c9e2c88ced4a6aa8f07de4e2d1a56a",
            "input": "Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.",
            "output": [
                "Zidovudine"
            ]
        },
        {
            "id": "task1447-b5c664879cdf4cb88442d48f7e20e61b",
            "input": "Celiprolol pneumonitis.",
            "output": [
                "Celiprolol"
            ]
        },
        {
            "id": "task1447-356e179b2584452a95db38e2e0a03ea4",
            "input": "Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.",
            "output": [
                "celiprolol"
            ]
        },
        {
            "id": "task1447-b32c8402ab5d45999a3f89eddbaf46f2",
            "input": "We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.",
            "output": [
                "celiprolol"
            ]
        },
        {
            "id": "task1447-d9b045440e47440cbb9c2a14da2a4034",
            "input": "Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.",
            "output": [
                "Ibopamine"
            ]
        },
        {
            "id": "task1447-ded97cc2a5594a938c8f1b61a7e1b4f6",
            "input": "Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.",
            "output": [
                "ibopamine"
            ]
        },
        {
            "id": "task1447-8d71004fdf3f4ff6a9dcbf490e7784cb",
            "input": "Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.",
            "output": [
                "Diphenylhydantoin"
            ]
        },
        {
            "id": "task1447-3b6cecb915c5444f834353109609cca2",
            "input": "Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.",
            "output": [
                "diphenylhydantoin"
            ]
        },
        {
            "id": "task1447-c1e65b3e57db4bdd8d68f955624108a8",
            "input": "A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.",
            "output": [
                "bromocriptine"
            ]
        },
        {
            "id": "task1447-b2069418e17548cf92f7ee0aa3629c89",
            "input": "Bromocriptine-induced schizophrenia.",
            "output": [
                "Bromocriptine"
            ]
        },
        {
            "id": "task1447-1d8b1e573d6f4c269d8b2900f144458f",
            "input": "The association of phenothiazine overdose and respiratory distress syndrome merits consideration.",
            "output": [
                "phenothiazine"
            ]
        },
        {
            "id": "task1447-73b808482448404e9e5caeb10b1bb927",
            "input": "In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.",
            "output": [
                "apomorphine"
            ]
        },
        {
            "id": "task1447-c5e346ad07634655927458ea3ab56607",
            "input": "We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.",
            "output": [
                "levo-dopa"
            ]
        },
        {
            "id": "task1447-40a53403aec24d78b30b7b3d2f3f5da5",
            "input": "This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.",
            "output": [
                "ddI"
            ]
        },
        {
            "id": "task1447-7893a5d14c0648efb7bc2c237f447d4a",
            "input": "Generalized argyria after habitual use of AgNO3.",
            "output": [
                "AgNO3"
            ]
        },
        {
            "id": "task1447-b7ca0ff0c93a4491a7299ec8ba7663f7",
            "input": "A case of fluoxetine induced seizures, in a person with Down syndrome, is described.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-c842cabe65c04a87995608dd1da05f03",
            "input": "Seizures associated with fluoxetine therapy are uncommon.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-87279a0b82a240e483a8e9dd82bb5be3",
            "input": "Seizures associated with fluoxetine therapy.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-0db86b9848f84aa7aaa8c6a645e795e6",
            "input": "Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.",
            "output": [
                "fluoxetine"
            ]
        },
        {
            "id": "task1447-194ceee03c2243b283a6b9a5499137b7",
            "input": "A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-96b06b5c411c4a80b7f014bdf34338be",
            "input": "Electrical proarrhythmia with procainamide: a new ICD-drug interaction.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-460a20f8b54949d98ce29721a299a949",
            "input": "The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-ea8d637dec944f50988e7753e2d7ce3b",
            "input": "Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-313541933d174db7afd7601c57b76935",
            "input": "Central nervous system toxicity associated with meperidine use in hepatic disease.",
            "output": [
                "meperidine"
            ]
        },
        {
            "id": "task1447-c41a7215d6524ad39ed70b0688db5034",
            "input": "Clonidine-induced bradycardia in patients with spinal cord injury.",
            "output": [
                "Clonidine"
            ]
        },
        {
            "id": "task1447-4c1a4eb366c246f9b6cc22a8441d44de",
            "input": "Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.",
            "output": [
                "nitrous oxide"
            ]
        },
        {
            "id": "task1447-678ec7d1cd254f7887b6da5fb5ad97c8",
            "input": "Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.",
            "output": [
                "nitrous oxide"
            ]
        },
        {
            "id": "task1447-b9ef765ade274ee6a1b00d2323c01d3e",
            "input": "Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.",
            "output": [
                "nitrous oxide"
            ]
        },
        {
            "id": "task1447-87362d10de2c440aa5dc63755f516abb",
            "input": "BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.",
            "output": [
                "Fluoxetine"
            ]
        },
        {
            "id": "task1447-a8909d862dae4decb313bbb2c323365e",
            "input": "Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-5599834ef7fb426095ddd661eb06fea1",
            "input": "Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-c86085ea34454889918c0dadde6c4f4c",
            "input": "We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-815ea0fef102430d89d989a756e46bd6",
            "input": "Can magnesium sulfate therapy impact lactogenesis?",
            "output": [
                "magnesium sulfate"
            ]
        },
        {
            "id": "task1447-1423555d689749c28eec97f288891238",
            "input": "No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.",
            "output": [
                "magnesium sulfate"
            ]
        },
        {
            "id": "task1447-b1d7bd44ccaa44f3aab6604ba48343d7",
            "input": "Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.",
            "output": [
                "Imidazoline"
            ]
        },
        {
            "id": "task1447-280975af5e6f49a6b1b576e76eb58a24",
            "input": "Imidazoline intoxication in children.",
            "output": [
                "Imidazoline"
            ]
        },
        {
            "id": "task1447-4add52baee594f7eb8787ec57327c650",
            "input": "Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-c9a89c092d1046ae8f8e32568e3cd3e6",
            "input": "A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-749e31674e8049afaba336307993dd99",
            "input": "Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.",
            "output": [
                "Lithium"
            ]
        },
        {
            "id": "task1447-55e4050fe6be4b46bca3c4ce907e89b1",
            "input": "Regression of thyrotoxic ophthalmopathy following lithium withdrawal.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-a9f30ddf0d8e4fee92f1552eb348678a",
            "input": "The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-29cec7fa0d874bf8b802e29b8e9b9df3",
            "input": "Severe abdominal pain in low dosage clofazimine.",
            "output": [
                "clofazimine"
            ]
        },
        {
            "id": "task1447-80d12d7c15cd40e699c481ef612ea888",
            "input": "We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain.",
            "output": [
                "clofazimine"
            ]
        },
        {
            "id": "task1447-c3fd338150e94e41a2723b389ef2d05c",
            "input": "Amphotericin B overdose in pediatric patients with associated cardiac arrest.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-a136595d99494d61ae02849433c68e42",
            "input": "CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.",
            "output": [
                "Amphotericin B"
            ]
        },
        {
            "id": "task1447-7c7d1f5052244a1ab37adca317549c56",
            "input": "INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-528f4b122ec447c5a6375cf2e70d262d",
            "input": "OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-493fc1033a074cc49ad8ee051d0671e8",
            "input": "Sudden death in an infant from methemoglobinemia after administration of \"sweet spirits of nitre\".",
            "output": [
                "sweet spirits of nitre"
            ]
        },
        {
            "id": "task1447-3c1ed48a42084a868d4edb32e7e09000",
            "input": "L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.",
            "output": [
                "valproic acid"
            ]
        },
        {
            "id": "task1447-1567ab0426554d07b6934189cf0af534",
            "input": "A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.",
            "output": [
                "IL-2"
            ]
        },
        {
            "id": "task1447-6fb6f5c3730e4174a1c0f4d23dc7683f",
            "input": "Delayed neurotoxicity of intraventricular interleukin-2: a case report.",
            "output": [
                "interleukin-2"
            ]
        },
        {
            "id": "task1447-30a1ddc604c7408f9a038c44ab3dc7bf",
            "input": "Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-1e6c19e49cf744a380993825a9201bde",
            "input": "Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-31bee2a9015b441f9b372a62a24fcdc1",
            "input": "Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.",
            "output": [
                "Lithium"
            ]
        },
        {
            "id": "task1447-3bc8b405e2ea40809d75c80d04005a8a",
            "input": "They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-95bbe4728cdd4a21a836d984dd927d08",
            "input": "CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.",
            "output": [
                "foscarnet"
            ]
        },
        {
            "id": "task1447-c3857303ae77485fb7a1ff62abc6c683",
            "input": "DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.",
            "output": [
                "foscarnet"
            ]
        },
        {
            "id": "task1447-a09d51e6665847009dc8d25da64197e0",
            "input": "Interference with the cortisol axis by the microtubule antagonist, CPH82.",
            "output": [
                "CPH82"
            ]
        },
        {
            "id": "task1447-5392bbc5414b4487afa7b19de2314003",
            "input": "Carbamazepine-induced tics.",
            "output": [
                "Carbamazepine"
            ]
        },
        {
            "id": "task1447-6c32c0fb85ee49388780b07e040e4134",
            "input": "In the third child, the tics ceased after CBZ discontinuation.",
            "output": [
                "CBZ"
            ]
        },
        {
            "id": "task1447-ab103216ecb14d799026cbcbac7a392b",
            "input": "These cases demonstrate that CBZ can induce simple motor tics in children.",
            "output": [
                "CBZ"
            ]
        },
        {
            "id": "task1447-56cfe9af5172489188b4f0658d6ae177",
            "input": "We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.",
            "output": [
                "CBZ"
            ]
        },
        {
            "id": "task1447-6280dfd0817f4d5c98b577db70260345",
            "input": "Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.",
            "output": [
                "Acyclovir"
            ]
        },
        {
            "id": "task1447-266aab08dd114418a8c87820940fb9c8",
            "input": "A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.",
            "output": [
                "tryptophan"
            ]
        },
        {
            "id": "task1447-c1535ad07295483b9605bc6102cb0051",
            "input": "Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.",
            "output": [
                "tryptophan"
            ]
        },
        {
            "id": "task1447-2597d631ec32405c90fd21edb1bc6ecf",
            "input": "Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.",
            "output": [
                "tryptophan"
            ]
        },
        {
            "id": "task1447-05837fc34e3f472eb77d707d07692335",
            "input": "A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-542133ff6f004b019d503ccf1e72fb85",
            "input": "Rhabdomyolysis associated with the use of intravenous vasopressin.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-d60bb7c22f3a44c5a536903acdb9ee69",
            "input": "These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.",
            "output": [
                "vasopressin"
            ]
        },
        {
            "id": "task1447-f1c937b70bf44e7da931f92816f1340b",
            "input": "In one case, disulfiram was the only potential teratogen exposed to the fetus.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-5ea6ff951baa4f46a6107b6479d8b2e0",
            "input": "Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.",
            "output": [
                "disulfiram"
            ]
        },
        {
            "id": "task1447-aaf097c55daa47999205dba6d73f5a22",
            "input": "Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.",
            "output": [
                "penicillamine"
            ]
        },
        {
            "id": "task1447-fcaca14aae304502ae8eee57c9d6575b",
            "input": "Pemphigus vulgaris precipitated by glibenclamide therapy.",
            "output": [
                "glibenclamide"
            ]
        },
        {
            "id": "task1447-5bd3002dab184cecaa11b774b76c48f0",
            "input": "The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.",
            "output": [
                "glibenclamide"
            ]
        },
        {
            "id": "task1447-937eef1b06f443c496dfb50054da852f",
            "input": "Piritrexim-induced pulmonary toxicity.",
            "output": [
                "Piritrexim"
            ]
        },
        {
            "id": "task1447-e05850f283e448bf89424c0f28a01457",
            "input": "The pulmonary toxicity is probably induced by piritrexim.",
            "output": [
                "piritrexim"
            ]
        },
        {
            "id": "task1447-0e42887f80154148a2f4d1b7f80dfad7",
            "input": "Acceleration of ventricular response to atrial flutter after intravenous adenosine.",
            "output": [
                "adenosine"
            ]
        },
        {
            "id": "task1447-d2a81220bd3d4270a07c61e4b3a51217",
            "input": "Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-13a3aaae4502436289d7edbfb320c650",
            "input": "The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-9edbf0e9b0a748898ae4289587da4e7d",
            "input": "We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-15edc9422808497b9e8261070d7c33a3",
            "input": "Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.",
            "output": [
                "paracetamol"
            ]
        },
        {
            "id": "task1447-a81d34b264b246bbaaac76f834437dba",
            "input": "Two fatal cases of poisoning by paracetamol are described.",
            "output": [
                "paracetamol"
            ]
        },
        {
            "id": "task1447-b45ff24a88884829a559d4fecfde6a56",
            "input": "We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.",
            "output": [
                "prednisolone"
            ]
        },
        {
            "id": "task1447-f67fea75946d4dab9582eef57c4b8ccd",
            "input": "Acute dystonic reaction with low-dose pimozide.",
            "output": [
                "pimozide"
            ]
        },
        {
            "id": "task1447-fc24459dabc540029d11df072b29f605",
            "input": "Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.",
            "output": [
                "haloperidol"
            ]
        },
        {
            "id": "task1447-e3f5a1bf77f340138df84f3b9efa0efb",
            "input": "All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-38e53aad899f47e3ba3ba7445d33e50e",
            "input": "How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.",
            "output": [
                "gold"
            ]
        },
        {
            "id": "task1447-38fe258ef0fd4a5692db08edbd988206",
            "input": "Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.",
            "output": [
                "phenol"
            ]
        },
        {
            "id": "task1447-cc914a8a9df349448c5b51212ffe1380",
            "input": "We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.",
            "output": [
                "phenol-glycerine"
            ]
        },
        {
            "id": "task1447-768778d6c546429a8b4abb24de9e9629",
            "input": "Azathioprine can cause severe myelosuppression.",
            "output": [
                "Azathioprine"
            ]
        },
        {
            "id": "task1447-2acda7814e204d6cae9bb4d8d9626a3e",
            "input": "Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.",
            "output": [
                "Azathioprine"
            ]
        },
        {
            "id": "task1447-3d8a305d36094928a9b30d6c32b0e257",
            "input": "The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-569313d0abcd4be9a1c974eb61bfb855",
            "input": "Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-9e567c804c2a492c8fb244162e8b10a8",
            "input": "We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.",
            "output": [
                "azathioprine"
            ]
        },
        {
            "id": "task1447-95d0e59f99d34bd0b71ffd830e223064",
            "input": "Nabumetone-associated interstitial nephritis.",
            "output": [
                "Nabumetone"
            ]
        },
        {
            "id": "task1447-8d301197b4014e6d8aec74879f332dab",
            "input": "She had been taking nabumetone for 6 months, but had discontinued the agent 2 weeks before admission due to progressive edema.",
            "output": [
                "nabumetone"
            ]
        },
        {
            "id": "task1447-4c7e60d42c1f4ba9b47fca62ba110c3a",
            "input": "Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-6980cc08fa4b49f9a8d51bb041b50684",
            "input": "In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-140ccace20bc477a8293327a97e1b5a6",
            "input": "Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.",
            "output": [
                "hydroxyurea"
            ]
        },
        {
            "id": "task1447-31b1b89f0e1c4308833875b7e061610a",
            "input": "In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.",
            "output": [
                "halofantrine"
            ]
        },
        {
            "id": "task1447-471ca84dd11b4ef3a43f5095ab58644f",
            "input": "Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.",
            "output": [
                "halofantrine"
            ]
        },
        {
            "id": "task1447-0aeb7ea42a9c407c9198410e2ec5daa6",
            "input": "Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.",
            "output": [
                "CHOP"
            ]
        },
        {
            "id": "task1447-aabb597b470e4d88a0b4083c066a652a",
            "input": "We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.",
            "output": [
                "CHOP"
            ]
        },
        {
            "id": "task1447-db1b248c85bd4fd88d6d1195e0f871d2",
            "input": "Phenytoin toxicity due to concomitant antituberculosis therapy.",
            "output": [
                "Phenytoin"
            ]
        },
        {
            "id": "task1447-9fc6cd2148724e0baf584b850498b1e4",
            "input": "Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-35c1d2f165564dbba377bdcaea960172",
            "input": "Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-a43bbc2ba57341b79252b9b93bd8f430",
            "input": "No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.",
            "output": [
                "foscarnet"
            ]
        },
        {
            "id": "task1447-eb1ad1df2cb74b5eacf4aed79127ab78",
            "input": "Choroidal hemorrhage associated with systemic tissue plasminogen activator.",
            "output": [
                "tissue plasminogen activator"
            ]
        },
        {
            "id": "task1447-6c5883809c6540959282da1a89dc7638",
            "input": "PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.",
            "output": [
                "tissue plasminogen activator"
            ]
        },
        {
            "id": "task1447-76229949a66444999b315ee53151c9a4",
            "input": "Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-57e2b1030c8f4f71afeaa4ad95ebbb10",
            "input": "Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-8d1c36ed4ff943b5967f12174e376857",
            "input": "The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-52f7b251b8514b8294fdd2c6bf44d097",
            "input": "We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-b90eeaa6e710482ba6eeb20bda29de36",
            "input": "Jaundice induced by streptokinase.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-3dee1489283b47c2bc7838099fc58272",
            "input": "Only a few reports of overt jaundice are associated with streptokinase.",
            "output": [
                "streptokinase"
            ]
        },
        {
            "id": "task1447-97d49e66c79e40c09755852b04d50e66",
            "input": "Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-21c522b5227b4a40b2964323bd633339",
            "input": "Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-3283161612dc4107b750dd7e39dabe24",
            "input": "Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-c46b95fb368a4d6f8d7b5b3d48c8b05d",
            "input": "Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-1b8b271ca5c7434486f1973808d0c4cf",
            "input": "Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-20f3d25416994f15b16a596925b72deb",
            "input": "The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-54585969fa5c4a4c917c74b0b5a3b558",
            "input": "A patient with severe cholestatic jaundice induced by captopril is presented.",
            "output": [
                "captopril"
            ]
        },
        {
            "id": "task1447-507ec00dd5cd45c59b9c1e94658db84d",
            "input": "Captopril-associated \"pseudocholangitis'.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-96a2b46e5d3a4b2992454f7dbdeba3f9",
            "input": "Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.",
            "output": [
                "Captopril"
            ]
        },
        {
            "id": "task1447-66ad03b8f4df43b6bb83fb0d80736375",
            "input": "Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.",
            "output": [
                "macrophage-colony-stimulating factor"
            ]
        },
        {
            "id": "task1447-c89f2658be604f908e10ba14dd44ec49",
            "input": "It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.",
            "output": [
                "M-CSF"
            ]
        },
        {
            "id": "task1447-67e8aa1383b14564a8251ebd7a69fdfa",
            "input": "These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.",
            "output": [
                "M-CSF"
            ]
        },
        {
            "id": "task1447-6a55fe52713d4501a0d0361cd04b3c82",
            "input": "Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.",
            "output": [
                "1,25(OH)2D"
            ]
        },
        {
            "id": "task1447-0052dcf2a2d945cfbd5d308af8af1b72",
            "input": "CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-e28cf5efd3b243d484cce664d04d1daa",
            "input": "DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-b3a23fa909be4e79a64a12a3ecfbf424",
            "input": "Ifosfamide-induced nonconvulsive status epilepticus.",
            "output": [
                "Ifosfamide"
            ]
        },
        {
            "id": "task1447-ab038c02a74e4e928eb041bce8c82fd9",
            "input": "OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-1f22da933f774551b34ccb5e65fb2a4e",
            "input": "This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.",
            "output": [
                "ifosfamide"
            ]
        },
        {
            "id": "task1447-dd6ffbe22dcf449a908919b8bffdfe2f",
            "input": "Albendazole-induced pseudomembranous colitis.",
            "output": [
                "Albendazole"
            ]
        },
        {
            "id": "task1447-9378faba0a614a759b46de7d515fe37a",
            "input": "Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.",
            "output": [
                "metronidazole"
            ]
        },
        {
            "id": "task1447-3f602859dad045c7a823b80c9e4d4402",
            "input": "Oculomotor disturbances associated with 5-fluorouracil chemotherapy.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-96b206a6b2e3403d98a8b6e9c40c21a1",
            "input": "Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-1acafac0870c4e15aff5c297a34c32f0",
            "input": "Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.",
            "output": [
                "fluticasone propionate"
            ]
        },
        {
            "id": "task1447-c6d37afb41764477bb6c08b48c1912c7",
            "input": "METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).",
            "output": [
                "fluticasone propionate"
            ]
        },
        {
            "id": "task1447-f6aea3a16e024ba4b328432911059908",
            "input": "Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.",
            "output": [
                "Metipranolol"
            ]
        },
        {
            "id": "task1447-faadbf2cd5c14f81a0fa380722c38e1e",
            "input": "Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.",
            "output": [
                "metripranolol"
            ]
        },
        {
            "id": "task1447-49891bef5d8649a59e8859dcc32b03aa",
            "input": "Intranasal desmopressin-induced hyponatremia.",
            "output": [
                "desmopressin"
            ]
        },
        {
            "id": "task1447-28e95eefb35b408c99263f014611e674",
            "input": "Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.",
            "output": [
                "desmopressin"
            ]
        },
        {
            "id": "task1447-cc0afbda11fd47c883ea801afab7c650",
            "input": "Does acyclovir increase serum lithium levels?",
            "output": [
                "acyclovir"
            ]
        },
        {
            "id": "task1447-221451ea3e734d3c8d6653437a6e3587",
            "input": "Dapsone syndrome in cutaneous lupus erythematosus.",
            "output": [
                "Dapsone"
            ]
        },
        {
            "id": "task1447-245763fc07444828a28bfb2b0d08fcc5",
            "input": "Physicians should be aware of the potentially lethal side effects of dapsone.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-6cba314633b642d8bf331569a39804cb",
            "input": "A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.",
            "output": [
                "minoxidil"
            ]
        },
        {
            "id": "task1447-5fe93203901240a4b65da93865c2571e",
            "input": "Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-dfe766169f91494eafd7a93abe6a4a3a",
            "input": "This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-e9ca8fd220ac4fcbaec2300543ef9a23",
            "input": "Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-b9577e7741f8491f8ff18f708b7febd3",
            "input": "We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.",
            "output": [
                "lithium"
            ]
        },
        {
            "id": "task1447-6d9496d3b4354ef19d8338872fe2391b",
            "input": "CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.",
            "output": [
                "human insulin"
            ]
        },
        {
            "id": "task1447-f6c9d639be4d46a3be15041350b6111f",
            "input": "Human insulin-induced lipoatrophy.",
            "output": [
                "Human insulin"
            ]
        },
        {
            "id": "task1447-defa1592cae2405abf3dadbdb549c2ce",
            "input": "OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.",
            "output": [
                "human insulin"
            ]
        },
        {
            "id": "task1447-4c3ab9520e6745b3ac5af442d98c15d7",
            "input": "Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-4ff19a1b07e548a0bad4bbca6971f845",
            "input": "Seizures associated with ofloxacin therapy.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-b716b31abfb34e1faa51c31620697ae7",
            "input": "We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.",
            "output": [
                "ofloxacin"
            ]
        },
        {
            "id": "task1447-cabec165070e4920b9817f68996ba62a",
            "input": "Systemic corticosteroids in the phenytoin hypersensitivity syndrome.",
            "output": [
                "phenytoin"
            ]
        },
        {
            "id": "task1447-de06aef52ac14d3da0ba514568b74ce0",
            "input": "A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-7dfab04284af4fabaf3b6ca1051b57ef",
            "input": "Sarcoma complicating therapy with cyclophosphamide.",
            "output": [
                "cyclophosphamide"
            ]
        },
        {
            "id": "task1447-1487930feab04e3aacd5ac01e8838241",
            "input": "A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-ea923231c0784b4895abb4c5e382c3f9",
            "input": "Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-5a4fda59db1b4cd182ec1b056c916f32",
            "input": "Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.",
            "output": [
                "Nitrofurantoin"
            ]
        },
        {
            "id": "task1447-216fa022ec6b4a9c909c9b8a1d2a6e7e",
            "input": "We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.",
            "output": [
                "nitrofurantoin"
            ]
        },
        {
            "id": "task1447-cb7d7912c1734cda81bd902693d76840",
            "input": "Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.",
            "output": [
                "dapsone"
            ]
        },
        {
            "id": "task1447-6e42050018da4e13b2dfd298269f0e31",
            "input": "Acetazolamide-accelerated anticonvulsant osteomalacia.",
            "output": [
                "Acetazolamide"
            ]
        },
        {
            "id": "task1447-bdbd25e799be478f8af40181f9ecd46c",
            "input": "Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.",
            "output": [
                "Acetazolamide"
            ]
        },
        {
            "id": "task1447-be276eb7940346c0a187d696ed877edf",
            "input": "The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.",
            "output": [
                "methotrexate"
            ]
        },
        {
            "id": "task1447-d64f60c8d1bd43ab9807c7d302c7df53",
            "input": "A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires.",
            "output": [
                "loperamide"
            ]
        },
        {
            "id": "task1447-a33e357705794dc68bed7a9e39a52a1c",
            "input": "Loperamide poisoning in the dog.",
            "output": [
                "Loperamide"
            ]
        },
        {
            "id": "task1447-9b5c76cd50d8436fba206f42065aeb80",
            "input": "a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.",
            "output": [
                "lithium carbonate"
            ]
        },
        {
            "id": "task1447-36f4b243e90d4b9cbfc447a0c89f15d0",
            "input": "Lithium-induced Creutzfeldt-Jakob syndrome.",
            "output": [
                "Lithium"
            ]
        },
        {
            "id": "task1447-d0c914f62bac479a999c5b97e72b93ac",
            "input": "We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.",
            "output": [
                "magnesium"
            ]
        },
        {
            "id": "task1447-bee993fb507d4d09bcfd0d8cdb4058c6",
            "input": "Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.",
            "output": [
                "terbinafine"
            ]
        },
        {
            "id": "task1447-dc0e13944c914226a08c5e3317918d81",
            "input": "Terbinafine-induced cholestatic liver disease.",
            "output": [
                "Terbinafine"
            ]
        },
        {
            "id": "task1447-13f40942e87847cabceb08c532362eb9",
            "input": "We describe a case of prolonged terbinafine-induced cholestatic liver disease.",
            "output": [
                "terbinafine"
            ]
        },
        {
            "id": "task1447-ecfcdefccf8c47dd8ea9dc0bbafaba3d",
            "input": "An unusual case of Ecstasy poisoning.",
            "output": [
                "Ecstasy"
            ]
        },
        {
            "id": "task1447-037edbda00df4944b2d3aac901f7d02a",
            "input": "We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.",
            "output": [
                "3,4-methylenedioxymet-amphetamine Ecstasy"
            ]
        },
        {
            "id": "task1447-c7aa590a54ac451ab7a7e9128d925a4f",
            "input": "However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.",
            "output": [
                "mequitazine"
            ]
        },
        {
            "id": "task1447-355b0d299b3b4861a30f4e12affbe8c1",
            "input": "Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.",
            "output": [
                "mequitazine"
            ]
        },
        {
            "id": "task1447-815908d458f54add9e62a1036c1745f0",
            "input": "Two cases of mequitazine-induced photosensitivity reactions.",
            "output": [
                "mequitazine"
            ]
        },
        {
            "id": "task1447-fc4bf90649af47d0b52744a9f6186509",
            "input": "Keratitis in methamphetamine abusers.",
            "output": [
                "methamphetamine"
            ]
        },
        {
            "id": "task1447-9cfc5aef37cc4ae688f087f00ce6c1fd",
            "input": "Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.",
            "output": [
                "Methamphetamine"
            ]
        },
        {
            "id": "task1447-3a3423b3896e4206a9fd9df816f9f40d",
            "input": "We report four cases of severe corneal ulceration in methamphetamine abusers.",
            "output": [
                "methamphetamine"
            ]
        },
        {
            "id": "task1447-98b8acac5f4c4344993a011af4f0eb28",
            "input": "CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-84b0b7655a214e62ab3b7d89bb9c29a4",
            "input": "Methotrexate-induced liver cirrhosis.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-0973c3322ff84e19abef497a1ab6a646",
            "input": "However, other factors or drugs (e.g. cresol) are thought to induce MH.",
            "output": [
                "cresol"
            ]
        },
        {
            "id": "task1447-5f56cda5107541b1bd8b11fe479e1aaa",
            "input": "This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.",
            "output": [
                "cresol"
            ]
        },
        {
            "id": "task1447-9ed1dddf09db426289a9be619bc01a15",
            "input": "The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.",
            "output": [
                "beclomethasone diproprionate"
            ]
        },
        {
            "id": "task1447-3ed0b2c482e84c8fa8e4e7d2430c570f",
            "input": "Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-ecbb5e0984784cafa23a7c016a8fdc14",
            "input": "The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-dfa27948f71f47f8aac356343dec90eb",
            "input": "When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.",
            "output": [
                "fludarabine"
            ]
        },
        {
            "id": "task1447-9814d2761a914ac58cf97d31cf81162f",
            "input": "She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.",
            "output": [
                "tobramycin"
            ]
        },
        {
            "id": "task1447-19856572ce784ac0b1caf4e82dfa8b0f",
            "input": "Tetany in a child with AIDS receiving intravenous tobramycin.",
            "output": [
                "tobramycin"
            ]
        },
        {
            "id": "task1447-8eee9f3404f94a0c87363cdf454bcd61",
            "input": "This pattern is suggestive of renal toxicity due to tobramycin.",
            "output": [
                "tobramycin"
            ]
        },
        {
            "id": "task1447-ea0124bd47c845498325b9f0fbce6a33",
            "input": "Insulin-induced lipoatrophy in type I diabetes.",
            "output": [
                "Insulin"
            ]
        },
        {
            "id": "task1447-87e7140c87de40f3b4179b413604a159",
            "input": "OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.",
            "output": [
                "insulin"
            ]
        },
        {
            "id": "task1447-dcaf4b75bbdd4296a127d1019e00e5ba",
            "input": "Methotrexate is an effective but potentially toxic treatment for psoriasis.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-99cf501b9e2d49a087e5a952be3b921a",
            "input": "After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.",
            "output": [
                "cimetidine"
            ]
        },
        {
            "id": "task1447-aef067f733df4baeb8a03290c294498c",
            "input": "Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.",
            "output": [
                "tolazoline"
            ]
        },
        {
            "id": "task1447-54d871a6b0c348aca8d5c43a486e9abf",
            "input": "Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.",
            "output": [
                "nitrite"
            ]
        },
        {
            "id": "task1447-f7f47821d11342bbabdf7c95f3e67a75",
            "input": "Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.",
            "output": [
                "nitrate"
            ]
        },
        {
            "id": "task1447-3f849b275f2d4b33b46f24706be5e842",
            "input": "Acute esmolol toxicity may be self-limiting because of its extremely short half-life.",
            "output": [
                "esmolol"
            ]
        },
        {
            "id": "task1447-89e43a3eb97d425993f5b8d42eb43d63",
            "input": "After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.",
            "output": [
                "esmolol hydrochloride"
            ]
        },
        {
            "id": "task1447-5a39964ec53146c78fb24c1db24675d3",
            "input": "Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.",
            "output": [
                "esmolol"
            ]
        },
        {
            "id": "task1447-a3a1894b7adc4689b520aad7041ea0ea",
            "input": "Atenolol induced memory impairment: a case report.",
            "output": [
                "Atenolol"
            ]
        },
        {
            "id": "task1447-f3e64016f7fc420db9c800cc136c9890",
            "input": "His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.",
            "output": [
                "atenolol"
            ]
        },
        {
            "id": "task1447-614b4d1cb7fa48039eeb3dd1412690c8",
            "input": "A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-7f2eb45d841345bdbb581363b8599c93",
            "input": "Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-194e9319865a4ce2adf6b84101568d53",
            "input": "We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-801ff4a528ad431fb6013451ff53f1a2",
            "input": "Psychotic disorder associated with isoniazid.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-59058b31bfa64c70b46b86f263e0b586",
            "input": "We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.",
            "output": [
                "isoniazid"
            ]
        },
        {
            "id": "task1447-c82b012a9f494c3c976ef9b297f789eb",
            "input": "Ketanserin in the treatment of protamine-induced pulmonary hypertension.",
            "output": [
                "protamine"
            ]
        },
        {
            "id": "task1447-edf5a2fbbea9471c860d1efb2ea63605",
            "input": "METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-ead902c9f10a4226b25d629759162f5b",
            "input": "over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-2f78e9b3e11c4ba9949676015fa40f3c",
            "input": "Uveitis associated with rifabutin therapy: a clinical alert.",
            "output": [
                "rifabutin"
            ]
        },
        {
            "id": "task1447-88b0c23f92474fea9550f2e246e460f4",
            "input": "CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.",
            "output": [
                "praziquantel"
            ]
        },
        {
            "id": "task1447-1dda08d618e648cd8c9b419856ee0a05",
            "input": "Large cerebral infarction during praziquantel therapy in neurocysticercosis.",
            "output": [
                "praziquantel"
            ]
        },
        {
            "id": "task1447-fc7a1db891e7493bace0c25f064c22f2",
            "input": "Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.",
            "output": [
                "5-fluorouracil"
            ]
        },
        {
            "id": "task1447-f482be2530e54d28bce727cdad8a0c27",
            "input": "Mesalamine-induced hypersensitivity pneumonitis.",
            "output": [
                "Mesalamine"
            ]
        },
        {
            "id": "task1447-429eca09612c43d4bdd0e3dc204ab476",
            "input": "Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.",
            "output": [
                "Mesalamine"
            ]
        },
        {
            "id": "task1447-9f69468c3ef54c358c6404f468f1a980",
            "input": "Immunosuppression elicited by the extensive administration of prednisolone was suspected for the initiation of the generalized mite infestation.",
            "output": [
                "prednisolone"
            ]
        },
        {
            "id": "task1447-58aefcf772d14725b291edf28d260437",
            "input": "CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-6e1508c2ed3d4ea398302a509d827eae",
            "input": "Delay of corneal wound healing in patients treated with colchicine.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-254dd2ff06f148a4b084b244230d35ea",
            "input": "The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-7cbffdfbf15046d0b34fd2b255592d1f",
            "input": "The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.",
            "output": [
                "colchicine"
            ]
        },
        {
            "id": "task1447-6df8317980564616a128c38af32e4d22",
            "input": "Fulminant hepatic failure associated with bicalutamide.",
            "output": [
                "bicalutamide"
            ]
        },
        {
            "id": "task1447-5f8f5d885a8c46f1b80be6dd6132f7cb",
            "input": "Delayed hypersensitivity to flurbiprofen.",
            "output": [
                "flurbiprofen"
            ]
        },
        {
            "id": "task1447-14918c30665440728ea90f2e3c9fbdaa",
            "input": "CONCLUSION: While thrombosis has been reported with GnRH-a therapy in men with prostate cancer, its association with treatment in this benign case may have been a consequence of the massive tumor size.",
            "output": [
                "GnRH-a"
            ]
        },
        {
            "id": "task1447-09777c31d6e448b7834de317af6357e0",
            "input": "Case study: adverse response to clonidine.",
            "output": [
                "clonidine"
            ]
        },
        {
            "id": "task1447-fde58329761043e0b903905ad42b726d",
            "input": "Four cases of adverse experiences with clonidine are described.",
            "output": [
                "clonidine"
            ]
        },
        {
            "id": "task1447-16ce096b68734d449cb88558013c2e82",
            "input": "Discontinuation of the itraconazole caused resolution of the drug eruption.",
            "output": [
                "itraconazole"
            ]
        },
        {
            "id": "task1447-ad6934c974d64d0492f067e232fe6f52",
            "input": "Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-db01942f8d47437aa15ed868ad30293f",
            "input": "The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.",
            "output": [
                "amiodarone"
            ]
        },
        {
            "id": "task1447-83c7d64ed00d4d2fab0b8b75ecea47cc",
            "input": "Acute asthma associated with sustained-release verapamil.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-a106efe96ba849f4aba9ab087145d0fe",
            "input": "OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-16d2d92700e647a786669d0b263bd6e0",
            "input": "She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.",
            "output": [
                "verapamil"
            ]
        },
        {
            "id": "task1447-afe675425278492ba6fedc1e38922baa",
            "input": "Cephalexin rash in infectious mononucleosis.",
            "output": [
                "Cephalexin"
            ]
        },
        {
            "id": "task1447-302f3e3bb9cc4bf88c571dadb3fd7ab3",
            "input": "The ampicillin rash occurring in cases of infectious mononucleosis is well documented.",
            "output": [
                "ampicillin"
            ]
        },
        {
            "id": "task1447-c9df4ce72f6f4dc88e9eae9139e34577",
            "input": "The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.",
            "output": [
                "cephalexin"
            ]
        },
        {
            "id": "task1447-52c5d5c83a564b77a5e5bec588f4ba13",
            "input": "A possible case of carbamazepine induced pancreatitis.",
            "output": [
                "carbamazepine"
            ]
        },
        {
            "id": "task1447-5758e0969d954cd6b27e101ea887a0d0",
            "input": "Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.",
            "output": [
                "Methotrexate"
            ]
        },
        {
            "id": "task1447-b06ad560eccd4a75ac87ebd95d79af88",
            "input": "On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-0995f2982fe7465aaa98452d4cb0ffec",
            "input": "Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-d50dcec8d04c4908895ec6f6f686bf6f",
            "input": "Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-776d99a542f340b882d62ce1d283ab1a",
            "input": "The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.",
            "output": [
                "MTX"
            ]
        },
        {
            "id": "task1447-5a715d7c78a147f798a20d8203a0b885",
            "input": "Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.",
            "output": [
                "ferrous sulfate"
            ]
        },
        {
            "id": "task1447-45ce073c9462440fa62ea1a16b72add9",
            "input": "We describe a patient who became hypothyroid while taking ferrous sulfate.",
            "output": [
                "ferrous sulfate"
            ]
        },
        {
            "id": "task1447-7f2b81f7323645c2b59beb8a35768ffc",
            "input": "However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.",
            "output": [
                "hepatitis B vaccination"
            ]
        },
        {
            "id": "task1447-cf9ead497d7d409a982630b9775dcb1b",
            "input": "Mental nerve neuropathy as a result of hepatitis B vaccination.",
            "output": [
                "hepatitis B vaccination"
            ]
        },
        {
            "id": "task1447-a99f84c6c5b544c7ae11fa8e2de2bd61",
            "input": "Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-9ee1aa2335d748f1a77d8320017e0f4a",
            "input": "An elderly man with procainamide hydrochloride-induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive (BFP) test result for syphilis.",
            "output": [
                "procainamide hydrochloride"
            ]
        },
        {
            "id": "task1447-2b85f661ca9d40808399f365b8e18a31",
            "input": "Circulating anticoagulant in the procainamide-induced lupus syndrome.",
            "output": [
                "procainamide"
            ]
        },
        {
            "id": "task1447-132537256f1148788107135c23814b3c",
            "input": "Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.",
            "output": [
                "magnesium sulfate"
            ]
        },
        {
            "id": "task1447-a964db80d5ac4909bd21880488f6c1e5",
            "input": "Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.",
            "output": [
                "magnesium"
            ]
        },
        {
            "id": "task1447-7b26e56410e24de5b4791ed103661f3a",
            "input": "Magnesium toxicosis in two horses.",
            "output": [
                "Magnesium"
            ]
        },
        {
            "id": "task1447-660087932ecc4d4f99c82729d6d43bd1",
            "input": "CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.",
            "output": [
                "lovastatin"
            ]
        },
        {
            "id": "task1447-de44599604754d09815c31c5068f8d92",
            "input": "DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.",
            "output": [
                "lovastatin"
            ]
        },
        {
            "id": "task1447-6f0e2a0e7ba24bfb80f7e9032ec20446",
            "input": "These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.",
            "output": [
                "prednisone"
            ]
        },
        {
            "id": "task1447-44c1b55509414a0bb38b0a12e2ea806d",
            "input": "Acute leukaemia during tamoxifen therapy.",
            "output": [
                "tamoxifen"
            ]
        },
        {
            "id": "task1447-ec1e4349b47f49edadb526e72bcd79a0",
            "input": "Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.",
            "output": [
                "Tamoxifen"
            ]
        },
        {
            "id": "task1447-96358f4219a545138b4399d6ae698842",
            "input": "Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.",
            "output": [
                "all-trans retinoic acid"
            ]
        },
        {
            "id": "task1447-e6fa2931f6574854a68aa43877b584c2",
            "input": "This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.",
            "output": [
                "ATRA"
            ]
        },
        {
            "id": "task1447-4f1a3739ef9742d49dacb165ab4265ff",
            "input": "Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.",
            "output": [
                "thionamide"
            ]
        },
        {
            "id": "task1447-d9ab715040f94974ba1811abe0a4d559",
            "input": "Propylthiouracil-induced cutaneous vasculitis.",
            "output": [
                "Propylthiouracil"
            ]
        },
        {
            "id": "task1447-3d5aab2f0d1545acade61ca8a33b4079",
            "input": "The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.",
            "output": [
                "propylthiouracil"
            ]
        },
        {
            "id": "task1447-9de40f3ab96d45f9ba1e0b31fc8c5072",
            "input": "A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.",
            "output": [
                "zonisamide"
            ]
        },
        {
            "id": "task1447-13eb823f0dd148e6985dd7d8949bff45",
            "input": "Heat stroke-like episode in a child caused by zonisamide.",
            "output": [
                "zonisamide"
            ]
        },
        {
            "id": "task1447-4ad5621c97ca49929c3810fa315c360c",
            "input": "The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.",
            "output": [
                "zonisamide"
            ]
        },
        {
            "id": "task1447-6eeb4f075e654bd183b8f1d07cc2a37b",
            "input": "Acute renal failure in a patient receiving treatment with suramin.",
            "output": [
                "suramin"
            ]
        },
        {
            "id": "task1447-e8a61faaa8424bda920e8fafbc3fa643",
            "input": "Acute renal failure should be recognized as a potential complication of suramin treatment.",
            "output": [
                "suramin"
            ]
        },
        {
            "id": "task1447-80527460bec147b0879a168b7c8ecc2e",
            "input": "Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.",
            "output": [
                "suramin"
            ]
        },
        {
            "id": "task1447-70dd380244d443649056b4a9c6fd02a2",
            "input": "We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.",
            "output": [
                "suramin"
            ]
        },
        {
            "id": "task1447-a3768151127042fcbc89f821cd93fe8f",
            "input": "Clozapine induced polyserositis.",
            "output": [
                "Clozapine"
            ]
        },
        {
            "id": "task1447-d1b72ad1652e4ef3be49657ba231dc5f",
            "input": "When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.",
            "output": [
                "amphotericin B"
            ]
        },
        {
            "id": "task1447-806743bc19074cbc953d9f59840c7e58",
            "input": "CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.",
            "output": [
                "rhGH"
            ]
        },
        {
            "id": "task1447-627c05b9d6234378b2dbeb68d65788e8",
            "input": "Hypercalcemia in an AIDS patient treated with growth hormone.",
            "output": [
                "growth hormone"
            ]
        },
        {
            "id": "task1447-219009d079434e4cac36ea6f72060676",
            "input": "The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up.",
            "output": [
                "rhGH"
            ]
        },
        {
            "id": "task1447-14c81b0c0dcf4c6aafb8383debc6f449",
            "input": "We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.",
            "output": [
                "rhGH"
            ]
        },
        {
            "id": "task1447-9bcfc6f3a8a542b2bf0b0d072a180dd8",
            "input": "Hypersensitivity reactions to cisplatin following multiple uncomplicated courses: a report on two cases.",
            "output": [
                "cisplatin"
            ]
        },
        {
            "id": "task1447-653c98a12aa04741b791108544bc92f6",
            "input": "We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.",
            "output": [
                "cisplatin"
            ]
        }
    ],
    "Instance License": [
        "Unknown"
    ]
}