{ "Contributors": [ "Ishan Purohit" ], "Source": [ "coda_19" ], "URL": [ "https://github.com/windx0303/CODA-19/tree/master/data" ], "Categories": [ "Section Classification" ], "Reasoning": [], "Definition": [ "In this task, you are given a sentence from the research paper and your task is to classify the given sentence into the following categories: Background (Why is this problem important? What relevant works have been created before? What is still missing in the previous works? What are the high-level research questions? How might this help other research or researchers?), Purpose (What specific things do the researchers want to do? What specific knowledge do the researchers want to gain? What specific hypothesis do the researchers want to test?), Method (How did the researchers do the work or find what they sought? What are the procedures and steps of the research?), or Finding (What did the researchers find out? Did the proposed methods work? Did the thing behave as the researchers expected?). " ], "Input_language": [ "English" ], "Output_language": [ "English" ], "Instruction_language": [ "English" ], "Domains": [ "Scientific Research Papers" ], "Positive Examples": [ { "input": "Efforts to control future SARS outbreaks depend on the accurate and early identification of SARS-CoV infected patients.", "output": "background", "explanation": "The sentence provides the background information regarding how they could control future SARS outbreaks depending on the accuracy of identification of some infected patients having SARS-CoV." }, { "input": "Then , we found that nonstructural protein 1 and viral RNA of H5N1 contributed to the induction of miR-200c-3p during viral infection.", "output": "finding", "explanation": "The sentence is about finding the contribution of protein 1 and viral RNA of H5N1 to induction of miR-200c-3p during viral infection." }, { "input": "In this review , we will discuss the application of protein microarray technologies that offer unique opportunities to find novel biomarkers.", "output": "purpose", "explanation": "This sentence discuss the purpose of the review regarding unique opportunities to find novel biomakers." } ], "Negative Examples": [ { "input": "prognosis and therapeutic monitoring of diseases continues in earnest despite dwindling success at finding novel reliable markers.", "output": "purpose", "explanation": "The sentence provides background information regarding therapeutic monitoring of diseases." }, { "input": "This study describes a novel blocking microsphere-based immunoassay for highly sensitive and specific detection of antibodies against bovine viral diarrhoea virus ( BVDV ).", "output": "background", "explanation": "The sentence provides purpose of the study. So, background is an incorrect a label." }, { "input": "The diagnostic performance of the assay was evaluated by testing a total of 509 serum samples.", "output": "finding", "explanation": "The sentence is describing the method of how the diagnostic performance of the assay was evaluated by testing some serum samples. It does not indicate any result/finding. Hence, correct output is a method." } ], "Instances": [ { "id": "task1163-ff12eeb6c0394db6babe8a83d155e1f3", "input": "we assessed representative vOTUs spanning the Nairoviridae family towards Ub and ISG15 fluorogenic substrates.", "output": [ "method" ] }, { "id": "task1163-590408a3701342cd8ba8441b934af358", "input": "The glycoprotein gene was inserted at the 1 st or the 3 rd position of the measles virus genome and the recombinant viruses were generated.", "output": [ "method" ] }, { "id": "task1163-d98815c7400646ad9bf37e0a8a5cd3a8", "input": "which agents deserve monitoring , and the appropriate frequency for such interventions.", "output": [ "purpose" ] }, { "id": "task1163-47c81fcad8a946988cf5574836fc997b", "input": "For each year , the reliability of the entire examination was calculated with Cronbach 's alpha.", "output": [ "method" ] }, { "id": "task1163-4f1460962a2d426e9408ce5b8ea6b745", "input": "and travellers coming from Hong Kong , Macau , and Taiwan.", "output": [ "method" ] }, { "id": "task1163-e7cd21bc7c934c2495634583c076af8b", "input": "The purpose of this study was to assess the efficacy of glucocorticoids add-on in the treatment of MRMP in children through systematic review and meta-analysis.", "output": [ "purpose" ] }, { "id": "task1163-d39a4a25eb554df88d045bd00acf2d9e", "input": "Objective To review systematically the evidence of effectiveness of physical interventions to interrupt or reduce the spread of respiratory viruses.", "output": [ "purpose" ] }, { "id": "task1163-52da3e8d61e7498baff94afcc6a64a18", "input": "In this article , we review the latest trends and future directions of the field.", "output": [ "purpose" ] }, { "id": "task1163-5421c94731784b848d7f877c41c08b84", "input": "a lot of problems are still waiting to be solved.", "output": [ "background" ] }, { "id": "task1163-28c114a69e654dd9b12ef75b6b033306", "input": "In this chapter , we describe a simple and effi cient protocol for total nucleic acids extraction to be used in conventional RT-PCR assay.", "output": [ "purpose" ] }, { "id": "task1163-e31e56f315e44ac5ad174c42bb04ce1f", "input": "We hypothesized that axonal damage recruits inflammatory cells to sites of Wallerian degeneration , leading to demyelination.", "output": [ "purpose" ] }, { "id": "task1163-f86218e326f54c06b32238177f8ca0d4", "input": "we briefly compare microchip CE with conventional CE and review developments in this technique that may be useful in diagnosis of major diseases.", "output": [ "purpose" ] }, { "id": "task1163-47c2bb8f495c452f9705e1937713eda9", "input": "angiotensins , neurokinins , and cytokines.", "output": [ "background" ] }, { "id": "task1163-9226e8d0c4a84aed869741979e5bd1d9", "input": "To demonstrate this possibility , we here tested the effects of TACE inhibitors on viral entry.", "output": [ "method" ] }, { "id": "task1163-d2c0cb2ce3e245539c3fc78a211c939c", "input": "which primarily cause infection of the upper respiratory and gastrointestinal tract of hosts.", "output": [ "background" ] }, { "id": "task1163-51cc2020d0344c7ebf04d1221d657420", "input": "The brain stem ( thalamus , mesencephalon , caudal colliculus ) was most severely affected.", "output": [ "finding" ] }, { "id": "task1163-cd0c29b60aaa43fab0309a8ed75c7516", "input": "as shown in Fig. 9 .1.", "output": [ "background" ] }, { "id": "task1163-720cbece35274471beeec0a28ea4384d", "input": "confirmed through laboratory tests , between July and September of 2009.", "output": [ "method" ] }, { "id": "task1163-5eb8a901b667487bbf8b949968f311f9", "input": "This paper reviews how immunomodulation through active vaccination has evolved in the past 25 years.", "output": [ "purpose" ] }, { "id": "task1163-b1d6bc21421243c386e9c9bc49894dc8", "input": "stakeholders , and private partners to support a growing network of individuals and agencies to achieve common goals to mitigate inter-and intra-species pathogen transmission via bioaerosols.", "output": [ "purpose" ] }, { "id": "task1163-a733dd35d7374234a2b8b77886c3ff8d", "input": "incorporating documentation review , field observations and interviews.", "output": [ "method" ] }, { "id": "task1163-8b66ec0c4c1541b6b0d433b018d6c2e6", "input": "Hospital-acquired infections ( HAIs ) are a major concern to healthcare systems around the world.", "output": [ "background" ] }, { "id": "task1163-a6a9573d222e479eacb5f2288755fd01", "input": "in vitro , for antibacterial , antifungal and antiviral activities.", "output": [ "method" ] }, { "id": "task1163-aed6a87cdfa744989188b609b601d3e9", "input": "Several digital data sources and systems have been advanced for use in augmenting traditional influenza surveillance systems.", "output": [ "background" ] }, { "id": "task1163-03576bb38cb04c82830c06857d44064b", "input": "Such techniques have given rise to aptamers with 1000 times greater binding affinities when compared to traditional SELEX.", "output": [ "background" ] }, { "id": "task1163-218311c8959146dc8659bb8b1cd367a2", "input": "The two external body surface washes and the homogenate samples were tested for H9N2 to distinguish exterior from interior viral load.", "output": [ "method" ] }, { "id": "task1163-bdf85104cf9349a5812126ddd25c78e8", "input": "based on the genomic analysis.", "output": [ "background" ] }, { "id": "task1163-7a2b7c25a32b495a93179f37cd18f5f5", "input": "forming ahelical dimers , increases replication of seven various DNA and RNA viruses in cells.", "output": [ "finding" ] }, { "id": "task1163-9830f7248d5048d09d78e71fd98e5350", "input": "Setting : AED , involving all local public emergency departments from 2001 to 2012.", "output": [ "method" ] }, { "id": "task1163-f8a5a63f2d3941a692d26118f8b2e2f7", "input": "The incidence was predominantly higher in males ( 86.21 % ) than females ( 13.79 % ).", "output": [ "finding" ] }, { "id": "task1163-1aa1e42cf17347aa87bcb6bdd47929cb", "input": "Canada-specific surveillance summary of illness in a cohort of returned Canadian travellers and new immigrants.", "output": [ "purpose" ] }, { "id": "task1163-afb54257b6a2478d863be77b8c13244b", "input": "only some oligodendrocytes , astrocytes and microglial cells are infected.", "output": [ "finding" ] }, { "id": "task1163-979ee1fa5ef44476943c077dc2e8c568", "input": "or the structural genes , and drastic changes in the sequences that regulate the expression of viral subgenomic mRNAs.", "output": [ "background" ] }, { "id": "task1163-afd4183b9b9d4c719f0c73a0adfa373e", "input": "particularly how viral proteins regulate NLRP3 inflammasome activation.", "output": [ "purpose" ] }, { "id": "task1163-bbcf20ee3dda4e0ca3ff95eec848ee0e", "input": "During fasting , activation of the nuclear receptor peroxisome proliferator-activated receptor alpha ( PPARA ) promotes the utilization of lipids as an energy source.", "output": [ "background" ] }, { "id": "task1163-35be9de852344f7a86a63ee6ff02f7a2", "input": "The aim of this study was to investigate the population structure of the S. aureus complex in E. helvum and to assess the geographical spread of S. aureus complex among other animals and humans.", "output": [ "purpose" ] }, { "id": "task1163-2e34af33a3284d8d85725d324547c2f5", "input": "Eighty-five participants ( 28.3 % ) randomized to gargling reported clinical URTI compared to 65 participants ( 21.7 % ) randomized to the no gargling arm ( RR : 1.3 , CI 95 : 0.92-1.57 , p = 0.19 ).", "output": [ "finding" ] }, { "id": "task1163-3dd2fa4e214e402684db220ccdff79fd", "input": "Lymphopenia can be used as an indicator of disease severity and prognosis of COVID-19 patients.", "output": [ "finding" ] }, { "id": "task1163-e7debf8b5b974c0ca59704e5848188fe", "input": "such as multi-drug resistant tuberculosis.", "output": [ "finding" ] }, { "id": "task1163-b77cf86752244a3abf60e791f18c9654", "input": "that quantitative fit testing is unreliable and that serious consideration should be given to the role of quantitative fit testing in future guidelines and standards.", "output": [ "finding" ] }, { "id": "task1163-668189cb50464db19df99a39a4fd18ea", "input": "and provide evidence for the absence of distinct evolutionary patterns/signatures in the genomes of the currently known major clades of SARS-CoV-2.", "output": [ "purpose" ] }, { "id": "task1163-02ea15b049bd4da78b34bfc9917ce6d2", "input": "Identification of a simple and effective indicator to assess disease severity and prognosis is urgently needed.", "output": [ "background" ] }, { "id": "task1163-f45bc63a5b2f4c4084949ca5a8102eb7", "input": "Immunoinformatics has recently emerged as a critical field for accelerating immunology research.", "output": [ "background" ] }, { "id": "task1163-5bc5c4c777ef44dcb0e0ae9f09fc0653", "input": "Here we use RNAsequencing and ribosome profiling to explore the mechanisms that are being utilized by the Influenza A virus ( IAV ) to induce host shutoff.", "output": [ "method" ] }, { "id": "task1163-0bf27e5e62c04c11a37874adb76b6fa0", "input": "median age 27.7 months ( interquartile range 13.9-60.3 months ).", "output": [ "method" ] }, { "id": "task1163-8644ead864ea4a7592a1296be6c3e4d9", "input": "It would be desirable to rapidly characterize such outbreaks and develop accurate projections of their duration and cumulative size even when limited preliminary data are available.", "output": [ "background" ] }, { "id": "task1163-26caa89b590d469dae3f8b434a3e2fa1", "input": "was taken as an example to demonstrate biological and ecological prerequisites which enables an invasive species to occupy a new habitat permanently.", "output": [ "background" ] }, { "id": "task1163-5cc6a7469f564fbfb4326bc5133974b4", "input": "for the selection of high-threat pathogens with cross-border potential that will become the focus of its preparedness activities.", "output": [ "purpose" ] }, { "id": "task1163-06c461918b2e45e995a14a38e438a4bb", "input": "The form is in six parts.", "output": [ "method" ] }, { "id": "task1163-67e94b7489474c708ac0fcb8a389ef4a", "input": "An observational study identified issues with potential for contamination related to gown use.", "output": [ "method" ] }, { "id": "task1163-fb5f312166184dc1aa58a9f0225cfeea", "input": "White Leghorn specific-pathogen-free chickens were immunized with EV71 antigens and a specific isolated immunoglobulin ( IgY ) was prepared from the chicken egg yolk.", "output": [ "method" ] }, { "id": "task1163-8e2c50c84b5c427089b024ea45191e84", "input": "clinical specimens from 225 cases suspected of canine ehrlichiosis were examined for clinical pathology and presence of the haemoparasites.", "output": [ "method" ] }, { "id": "task1163-8263af834f0a47fab3cc7551124aab61", "input": "Werner syndrome and Fanconi anemia J are related to genomic defects that involve G-quadruplex forming sequences.", "output": [ "background" ] }, { "id": "task1163-7d8b659b7c634364945516c6cad27713", "input": "TRIM25 binding does not inhibit initiation of capped-RNA-primed viral mRNA synthesis by the viral polymerase.", "output": [ "finding" ] }, { "id": "task1163-267ee7ca5cbe4ad88a8a7d4c59ce22c9", "input": "Increased relative expression was detected for IL-6 ( RE = 2.065 ).", "output": [ "finding" ] }, { "id": "task1163-8710bca4f3da45fca6b075993f8b1b05", "input": "We suggest that TMEV evolved frameshifting as a novel mechanism for removing ribosomes from the message ( a `` ribosome sink '' ) to downregulate synthesis of the 3 = - encoded replication proteins.", "output": [ "finding" ] }, { "id": "task1163-2fc8478a07e6407687c49ea43de68528", "input": "together with SARS coronavirus and Bat-SARS-like coronavirus.", "output": [ "finding" ] }, { "id": "task1163-53bbc95587684a5caf93012a94b66c41", "input": "Rather , the onset of RNA chain elongation is inhibited because TRIM25 prohibits the movement of RNA into the polymerase complex.", "output": [ "finding" ] }, { "id": "task1163-bf9d04a539744240be258020963ee1bd", "input": "the purpose of these membrane alterations remains unclear.", "output": [ "background" ] }, { "id": "task1163-6c5e13abbbf4457abcb796983e00de5c", "input": "This work examines the effect of delivering the licensed human vaccine ( Anthrax Vaccine Adsorbed , AVA ) combined with a CpG oligodeoxynucleotide ( ODN ) adjuvant intraperitoneally or intranasally to A/J mice.", "output": [ "purpose" ] }, { "id": "task1163-c914a1ebbd754567a04168cede0f0d63", "input": "lipid metabolism , and angiogenesis.", "output": [ "purpose" ] }, { "id": "task1163-903958ad73f947538d69064a881f7c3b", "input": "followed by epidemiological study in relation to age , breed , and sex.", "output": [ "method" ] }, { "id": "task1163-b669229e678640c8987427f38662ae67", "input": "Fifty-one patients had proven/probable aspergillosis.", "output": [ "background" ] }, { "id": "task1163-edcb0e2831f84aaa86189035372c19c1", "input": "was identified from a breeding colony of rats having X-linked severe combined immunodeficiency.", "output": [ "background" ] }, { "id": "task1163-391c7d3901b042bb8eac89ad5bc7b04d", "input": "grubii 's heat shock 70KDa protein were retrieved from NCBI protein database.", "output": [ "method" ] }, { "id": "task1163-b67eae1ba2914461a759f0356f568090", "input": "Thirty Holstein calves were monitored during their first 60 days of age.", "output": [ "method" ] }, { "id": "task1163-db72e04a76774defa480090d99052934", "input": "We conclude by posing hypotheses regarding how pathogen natural history influences transmission heterogeneity and highlight emerging frontiers in the study of transmission heterogeneity.", "output": [ "finding" ] }, { "id": "task1163-7609acb9a356465090ea08749cda32c5", "input": "were kept in a separate group , as controls.", "output": [ "method" ] }, { "id": "task1163-8578ee5a40584ecc8e2d7a565ad842d3", "input": "On the other hand , viruses has evolved many strategies to combat or utilize the host autophagy for their own benefit.", "output": [ "background" ] }, { "id": "task1163-b80e9445a01348e9bd515886b4646e2e", "input": "In this issue , two articles contribute to the dissemination of research results and practice guidelines.", "output": [ "purpose" ] }, { "id": "task1163-03c39af84cd7405b9a4e5cf4e0cf071b", "input": "We investigate the effects of delaying the time to recovery ( delayed recovery ) and of nonuniform transmission on the propagation of diseases on structured populations.", "output": [ "purpose" ] }, { "id": "task1163-06c9cb0d26724b54b4088ca4aee66f92", "input": "and systemic symptoms such as apnea , acidosis , and lethargy.", "output": [ "background" ] }, { "id": "task1163-32390e22ea4645bab7139a8b3a3d9433", "input": "Results : Of the 50 patients , 14 had confirmed SARS.", "output": [ "finding" ] }, { "id": "task1163-191c81957b6741eea7bae594174a72f2", "input": "Lactobacilli represent the dominant bacterial species able to prevent facultative and obligate anaerobes outnumber in vaginal microbiota maintaining healthy microbial homeostasis.", "output": [ "background" ] }, { "id": "task1163-a6dee3d73ca947c3b3f60eb44b53f6b4", "input": "In this study , RNAi technology has been applied to explore the possibility for prevention of SARS-CoV infection.", "output": [ "purpose" ] }, { "id": "task1163-e9fe5cd30e29488fa14c0126b4134e85", "input": "The median age was 63 years ( range , 19 to 97 years ) and 80 % had one or more pre-existing health condition ; 9 % died in hospital.", "output": [ "finding" ] }, { "id": "task1163-e80c93bbca8247e5aebdc52bbd86b719", "input": "During infection , multiple subgenomic ( sg ) mRNAs are transcribed from a mirror set of sg negative-strand RNA templates.", "output": [ "background" ] }, { "id": "task1163-c381924581e841eb8fcf7568752171f1", "input": "This study used microbiota high-throughput sequencing to compare the fecal microbial profile of healthy horses to that of geriatric microbial transplant recipients experiencing diarrhea and tested whether FMT restores microbiota diversity.", "output": [ "purpose" ] }, { "id": "task1163-e741465eb19941f3a93b48e390d707bb", "input": "and then discuss the mechanisms by which specific gene products antagonize the host innate immune response in cell culture models.", "output": [ "purpose" ] }, { "id": "task1163-351e09a2b1124fe68d16af4c901a144a", "input": "correspond to those showing early invasion of trypanosomes.", "output": [ "background" ] }, { "id": "task1163-bd8ee0ba74984afba455f9b24bf63f90", "input": "an important nonstructural protein , is responsible for most cleavage within the viral polyprotein and is critical for the processes of viral replication.", "output": [ "background" ] }, { "id": "task1163-f214e1b6da4f4ac4ac0243a82d3b6c2c", "input": "The secretion of chicken IFN-c and the proliferation of CD8 + T cells were tested using an ELISA kit and flow cytometry , respectively.", "output": [ "method" ] }, { "id": "task1163-1ccd6cf98c2a4ad4b8651533dd4376a6", "input": "Repeated oral and tracheal suction was performed.", "output": [ "finding" ] }, { "id": "task1163-17cea3298d2148c98524890415570fff", "input": "increased national and international measures are being taken to contain the outbreak.", "output": [ "background" ] }, { "id": "task1163-34a1aba1f556487d82277e975e6e59b4", "input": "particularly in adults ≥ 65 years old.", "output": [ "background" ] }, { "id": "task1163-6f3d028253ca465d843389269d461580", "input": "We collected nasopharyngeal swabs from symptomatic children with acute respiratory infection ( ARI ) during household visits and at health facilities.", "output": [ "method" ] }, { "id": "task1163-c50e1ba2440344d1b920ee35ed7f1aa1", "input": "it has been difficult to disentangle the relative impact of these forces empirically.", "output": [ "background" ] }, { "id": "task1163-8cfee59e3b6b497d89c2fb804e2d4f6d", "input": "bone marrow , and spleen have been used for library construction.", "output": [ "method" ] }, { "id": "task1163-cb0da979bd8c4f4abf64735167eb49b1", "input": "The explicit condition for which the system undergoes backward bifurcation is obtained.", "output": [ "method" ] }, { "id": "task1163-e87bf5d03cae41e7a097a0948dea2c27", "input": "blood , and feed samples by using the QIAamp RNA Mini Kit ( QIAGEN , Hilden , Germany ) according to the manufacturer 's instructions.", "output": [ "method" ] }, { "id": "task1163-461611f29d2c4faf93dddbb41aeea83c", "input": "OC43 , and MHV occurred less often in hospitalized children with lower respiratory tract disease ( 3.5 % ) than in a control group with non-respiratory tract disease ( 8.2 % ).", "output": [ "background" ] }, { "id": "task1163-a5c1d9f3f4aa45ce80dc84050dc60596", "input": "and the on-going research on enveloped plant viruses.", "output": [ "purpose" ] }, { "id": "task1163-295f8f86514d4327877fc681fa233155", "input": "In this paper , we study the dynamics of a vector-borne disease model with two transmission paths : direct transmission through contact and indirect transmission through vector.", "output": [ "purpose" ] }, { "id": "task1163-c719f1acdda04e68b5118bee6b826555", "input": "The accuracy of the FFD-Markov-chain model was similar to that of the other two models.", "output": [ "finding" ] }, { "id": "task1163-c6a1ea5a9fd04df9a9db7718a3727ef5", "input": "in general , are more efficacious against CQ-resistant strains than against CQ-susceptible strains.", "output": [ "finding" ] }, { "id": "task1163-46d8b4e8a4e44ce7a63f0777f8aea61d", "input": "for fast and slow axonal transport studies , respectively.", "output": [ "background" ] }, { "id": "task1163-73727cd137e74ae7b8aaf7fd374537df", "input": "The major Ig classes in bovine and human milk are IgA , IgG and IgM.", "output": [ "background" ] }, { "id": "task1163-57f8776e70bb4d668ce01966fe0ed63a", "input": "Here , we report the structure of the SARS-CoV S glycoprotein in complex with its host cell receptor ACE2 revealed by cryo-electron microscopy ( cryo-EM ).", "output": [ "purpose" ] }, { "id": "task1163-c0d89837f85546ad9293fdfae7d17c54", "input": "We conducted a systematic review to examine waterborne outbreaks following such events and explored their distribution between the different types of extreme water-related weather events.", "output": [ "purpose" ] }, { "id": "task1163-ca8d604c99d14aca971d9210614c4bb9", "input": "One candidate was also effective when administered orally in a rodent-based malaria model.", "output": [ "finding" ] }, { "id": "task1163-538e8cdbc75a41668e1cb006be13136e", "input": "pathways and diseases mediated by 3D domain swapping in the human proteome.", "output": [ "purpose" ] }, { "id": "task1163-a12322af670043bb886130391577eaae", "input": "and we recommend standardized assay conditions and constructs for routine SARS-CoV 3CLpro assays to facilitate direct comparisons between SARS-CoV 3CLpro inhibitors under development worldwide.", "output": [ "finding" ] }, { "id": "task1163-bfc042d085914f6588b1c3c75ab707c9", "input": "Several investigations have shown that pentoxifylline possesses broad-spectrum antiviral activity against a range of RNA and DNA viruses.", "output": [ "background" ] }, { "id": "task1163-fec149d589804e6890b1ea117929148a", "input": "2000 , to November 14 , 2002.", "output": [ "method" ] }, { "id": "task1163-34c9ab7e809b45fa8b3877667d681480", "input": "each of the APMV serotypes was found to replicate in hamsters.", "output": [ "finding" ] }, { "id": "task1163-1ff3ee7e3bdc461d9f298d788a4b0236", "input": "IFN-signature , and BPI gene expression raises the possibility that impairments in these pathways contribute to the susceptibility of LBW term infants to infection.", "output": [ "finding" ] }, { "id": "task1163-1fa83a09668043eea336432233fb3441", "input": "The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.", "output": [ "purpose" ] }, { "id": "task1163-cab45b53ab614fffbe082ea7a4486cd7", "input": "On the contrary , head was the most frequent non-fracture location , followed by forearm/elbow.", "output": [ "finding" ] }, { "id": "task1163-6bc0e2bf627248a085c359cf37d3fa88", "input": "A diagnosis of sinusitis was based on published criteria.", "output": [ "method" ] }, { "id": "task1163-842a3e5a81d149a1a6b8aad07dcd3389", "input": "The median with 95 % confidence interval ( CI ) of R0 values was 2.28 ( 2.06-2.52 ) estimated by the bootstrap resampling method.", "output": [ "finding" ] }, { "id": "task1163-7818f0a936d044d286d65678e50a5013", "input": "ineffective co-ordination between donors , questionable mechanisms of delivery and excessive loss of funding to `` middle men ''.", "output": [ "background" ] }, { "id": "task1163-9c2403ee8e744f53b7b12ad15a93b601", "input": "Avian infectious bronchitis virus ( IBV ) is a coronavirus which infects chickens ( Gallus gallus ) of all ages and causes significant economic losses to the poultry industry worldwide.", "output": [ "background" ] }, { "id": "task1163-1bd98751668546bc8ca4457c746e76b1", "input": "Turkey and the United States.", "output": [ "method" ] }, { "id": "task1163-858f81288b21449c91d7a57599e3090a", "input": "In this study , we evaluated the green tea extract as a safe personal hygiene against viral infections.", "output": [ "purpose" ] }, { "id": "task1163-0487a71f15724376a2c23be7434a70fd", "input": "The TGEV C and A epitopes were fused to the passenger domain of the MisL autotransporter of Salmonella.", "output": [ "method" ] }, { "id": "task1163-32fcc5e2bd07403986239b755d98366e", "input": "We also discuss the significance of programmed ribosomal frameshifting in a central region of the polyprotein open reading frame in some mosquito-associated flaviviruses.", "output": [ "finding" ] }, { "id": "task1163-761984e1035d4cd78c54fe8d1b26a250", "input": "the contribution from newspapers is also important.", "output": [ "purpose" ] }, { "id": "task1163-45c13e298c9d45f29088ff328e23cb57", "input": "The goal of this study was to develop a novel DENV infectious clone in a BAC under the control of the cytomegalovirus immediate-early promoter and to generate a virus with the fusion envelope-green fluorescent protein in an attempt to track virus infection.", "output": [ "purpose" ] }, { "id": "task1163-bd8c11344e7a46219e2002323cfa005f", "input": "To facilitate needed diagnosis , we developed and optimized a reverse transcription loop-mediated isothermal amplification ( RT-LAMP ) assay that detects all 4 serotypes of dengue virus ( DENV ).", "output": [ "method" ] }, { "id": "task1163-1463e330f0c44c9980a1389a80aff5d4", "input": "and public health professionals about seeking and providing health care and about reporting cases to health authorities are all influenced by the information environment , which changes constantly.", "output": [ "background" ] }, { "id": "task1163-6337b90fe06e4411b94795be808ae697", "input": "According to this hypothesis , in vitro experiments were performed to characterize the immunomodulatory effect of human adipose MSCs derived exosomes ( exo-hASCs ) on in vitro stimulated T cells.", "output": [ "method" ] }, { "id": "task1163-ac01d5d82e18419988b38491d57faea5", "input": "By contrast , the role of rhinovirus in precipitating attacks in children and young adults is strongly associated with allergy.", "output": [ "finding" ] }, { "id": "task1163-dedd15361e6d45c79c58b4782367378e", "input": "and could potentially be developed as a passive immunotherapy for EV71-and CVA16-induced HFMD.", "output": [ "finding" ] }, { "id": "task1163-97c2bf8c11824f0e9c19c29114bc9c02", "input": "Of 83 identified contacts , 81 were available for follow-up.", "output": [ "method" ] }, { "id": "task1163-50c09afb370b4df4b3b4ffd67e58a90e", "input": "The goal is to select the optimal air exchange rate that makes reasonable trade-offs among all the objectives.", "output": [ "purpose" ] }, { "id": "task1163-4493d624e3f546a3a69792e802fade7b", "input": "A particle swarm optimization ( PSO ) is used to optimize the scanning window to determine disease clusters.", "output": [ "method" ] }, { "id": "task1163-0173e0a762c14b36b2df058e22097d1b", "input": "including contaminated inanimate surfaces , radiology equipment , and associated medical devices.", "output": [ "purpose" ] }, { "id": "task1163-b6c379bdc06f4492b29049eed52fe3d1", "input": "provides the first line of defence against a broad array of microbial pathogens and trauma.", "output": [ "purpose" ] }, { "id": "task1163-d9b11ac13c6249e6818154da99a3e21c", "input": "recovered-type epidemic models consisting of ordinary differential equations.", "output": [ "method" ] }, { "id": "task1163-6ed51e84322f429ca167a14666902b4c", "input": "Aims were to investigate the different pathogens involved in ILI and describe the associated symptoms.", "output": [ "purpose" ] }, { "id": "task1163-8cf69b2208824d189e5e50f9746bdef6", "input": "and all are inhibitors of the BoNT/A LC.", "output": [ "background" ] }, { "id": "task1163-a13aa4d9c2f34a86b8fefa419d38a9a8", "input": "Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones.", "output": [ "background" ] }, { "id": "task1163-c21316f964d74499845f9ca5b825af55", "input": "18 children were sampled biweekly for respiratory pathogens , irrespective of respiratory symptoms.", "output": [ "method" ] }, { "id": "task1163-1c2e9f525e724d838f0fdbae32be4c77", "input": "With this division , the size of the vector population 64 2.", "output": [ "method" ] }, { "id": "task1163-90daa7bd989648b491d3d35c0c57c064", "input": "View is a key factor that influences property price.", "output": [ "background" ] }, { "id": "task1163-564185e2bb67474a8ca3a45551bcd267", "input": "cross-reactivity , and interference were evaluated as measures of analytical performance.", "output": [ "method" ] }, { "id": "task1163-28d09e9f1d6e492e8470c19d074e241c", "input": "Deregulation of this process is a major causative factor for many diseases.", "output": [ "background" ] }, { "id": "task1163-3ff6c9b2588b4cba83f10eec718822c8", "input": "The purpose of this Opinion article is to examine the nature of these hurdles and to provide food for thought on the main obstacles that impede this process.", "output": [ "purpose" ] }, { "id": "task1163-afc82ae86f3e4b8e878413016d845c3d", "input": "Implicating HSV1 further in AD is the discovery that HSV1 DNA is specifically localized in amyloid plaques in AD.", "output": [ "background" ] }, { "id": "task1163-302ee12975fa468080141bebadbbb690", "input": "during which influenza is most prevalent.", "output": [ "method" ] }, { "id": "task1163-11ce26222a214c89b6eda16aa339b583", "input": "This chapter attempts to summarize the current state of knowledge in this interesting field of HCV research.", "output": [ "purpose" ] }, { "id": "task1163-1b24f814653d4a6e83d4a59daa0082ca", "input": "In this study , RNA aptamers against SCV NTPase/Helicase ( nsP10 ) were isolated from RNA library containing random sequences of 40 nts using in vitro selection technique.", "output": [ "method" ] }, { "id": "task1163-c9e142a7f2e742b489136fa8acde2272", "input": "In the current study , we reported concurrent up-regulation of adenovirus E1a-associated 300 kDa protein p300 and GFAP in Tat-expressing human astroytoma cells and primary astrocytes.", "output": [ "finding" ] }, { "id": "task1163-14461d7a6ebb409ca9e2922ea58aefbd", "input": "This cross-sectional study determined the contamination of ID badges and lanyards worn by pediatric HCWs with common respiratory and gastrointestinal viruses.", "output": [ "purpose" ] }, { "id": "task1163-719e1ad18dd04156869c8838bdd566fb", "input": "Mutagenesis of cysteine clusters III and IV did not appreciably affect S cell-surface expression or S-mediated cell fusion.", "output": [ "finding" ] }, { "id": "task1163-8c974fcde6d54c3898949f2a5dbb3e03", "input": "Pooled mean 41 incubation period was 5.84 ( 99 % CI : 4.83 , 6.85 ) days.", "output": [ "finding" ] }, { "id": "task1163-e13a604bed0d442aac2d8ed00e6ce90c", "input": "Eventually attention is paid to new trends in dog feed such as feeding bones and raw meat.", "output": [ "background" ] }, { "id": "task1163-a75f6eca6c5b4fdebe29135fedd34cc3", "input": "( 2 ) To describe the system of External Quality Assessment on EM virus diagnosis ( EQA-EMV ) established in 1994 by our laboratory and its achievements.", "output": [ "purpose" ] }, { "id": "task1163-6aba814ebd5b4082bdef395742f4660d", "input": "Moreover , serotype-specific monoclonal antibodies ( MAbs ) bound similarly to infectious clone and the natural isolate.", "output": [ "finding" ] }, { "id": "task1163-5642ed9136bc4474b5a87b2d60e11d0d", "input": "The transcriptome map allowed the identification of 278 operon ( total 730 genes ) structures in the genome.", "output": [ "finding" ] }, { "id": "task1163-545e40e2d4984e0385436ff5c025e46f", "input": "• Mucosal immunoprophylaxis is theoretically an important approach to control infections acquired through these portals.", "output": [ "background" ] }, { "id": "task1163-bba0081ed2a349c99a296b8b72be9840", "input": "The diagnostic accuracy of the models was compared with that of physicians on the same set of patients.", "output": [ "method" ] }, { "id": "task1163-3376f1fac8764ff08b79c94b76b7c917", "input": "and potential negative feedback functions of autophagy in the host antiviral response.", "output": [ "purpose" ] }, { "id": "task1163-05d03272355f456f90d02c70c2d07d61", "input": "there are also strong similarities.", "output": [ "background" ] }, { "id": "task1163-789a85df07a14be1ae9543dc35887a4a", "input": "N.", "output": [ "background" ] }, { "id": "task1163-ab935d6a980e44b19beadecff5c4e98a", "input": "and whether it could stimulate cell-mediated antiviral activity.", "output": [ "purpose" ] }, { "id": "task1163-bd833a8cf0334f5cbf8650e0a9147a3c", "input": "transforming growth factor ( TGF ) - β1 induces differentiation of T helper ( Th ) 17 cells in mice.", "output": [ "background" ] }, { "id": "task1163-54a43718948e418b8fc2261dc0f8789e", "input": "and in 2018 , eight of the top ten bestselling drugs worldwide were biologics.", "output": [ "background" ] }, { "id": "task1163-147393ff62c8469c8ab2fea41d42a733", "input": "how these viruses integrate multifarious functions into one unique structure have enamored researchers for years.", "output": [ "background" ] }, { "id": "task1163-e5ea236bbf6e4c038ecaed76570c1491", "input": "At Time 1 , older adults ( N = 141 ) completed self-report measures of SDT ( perceived autonomy support from senior center staff , autonomous motivation for influenza prevention ) and TPB ( attitude , subjective norm , perceived behavioral control , and intention for influenza prevention ) constructs with respect to facemask used to prevent infection.", "output": [ "method" ] }, { "id": "task1163-5edd6addea5f4de785c9b199edb9377d", "input": "total-and anti-FPV specific IgGs , likely due to passive transfer of maternal immunity.", "output": [ "finding" ] }, { "id": "task1163-43aeb8a4eb134677a834c5e3cae73f34", "input": "Porcine epidemic diarrhea virus ( PEDV ) is a major causative agent of fatal diarrhea in piglets and is a serious problem in the hog-raising industry.", "output": [ "background" ] }, { "id": "task1163-f45107a057b249f48a74b6ed9f63bbee", "input": "this is the first report of experimental data for both the site of O-glycosylation and identity of the O-glycans attached on the subunit S1.", "output": [ "finding" ] }, { "id": "task1163-96065c1746934c93b389d32d0584991b", "input": ", etc..", "output": [ "background" ] }, { "id": "task1163-a7c2a61d8e6d4813a8bdc72198a93ae5", "input": "but there are no published data on their performance in airports.", "output": [ "background" ] }, { "id": "task1163-a87c179710944cbe825b178bc6a9247f", "input": "to our knowledge , of transmission of PVL-producing S. aureus to a physician during the resuscitation of an infant with fatal pneumonia.", "output": [ "purpose" ] }, { "id": "task1163-b7733e6d40924056bcede2557d4ce381", "input": "The model was parameterized for footrot in sheep.", "output": [ "method" ] }, { "id": "task1163-88fb484590374010b0a8e1e15478d79b", "input": "comprehensive searches of four electronic scientific literature databases were conducted for studies published in English from January 2004 to June 2014.", "output": [ "method" ] }, { "id": "task1163-63a4067b77a2400d81407fff60b27298", "input": "In this study , we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation.", "output": [ "purpose" ] }, { "id": "task1163-aef9b3cef232406bb68bb87385b3660e", "input": "Hand hygiene compliance rates increased from 73 % just before the occurrence of the first MERS case to 88 % during MERS cases ( P = .0001 ).", "output": [ "finding" ] }, { "id": "task1163-0aafa862e09744e4b591ca78fe1ef017", "input": "This knowledge can be utilized in further biological analysis to understand disease dynamics and isolate proteins for study as drug target candidates.", "output": [ "purpose" ] }, { "id": "task1163-22f2a50b9c3c4328bc76e0bcbc4f6e50", "input": "Currently , we study epigenetic effects on cellular methylation and transcription patterns in Ad12-infected cells and in Ad12-induced hamster tumor cells.", "output": [ "finding" ] }, { "id": "task1163-4b1303830b944331b4eedc529def4ea6", "input": "and may play a role in the pathology.", "output": [ "background" ] }, { "id": "task1163-a200c75bd9304eb7ace4371c8528a23d", "input": "We show the utility of the plug-and-play approach in the context of an investigation of measles transmission dynamics.", "output": [ "purpose" ] }, { "id": "task1163-2ef5301393774a5c9912b448af379dce", "input": "However , so far no drug against HIV-1 infection exhibiting this mechanism of action has been approved.", "output": [ "background" ] }, { "id": "task1163-520b0e29538446b3a2374ce22c2d4703", "input": "real-time PCR , flow cytometry and Western blot.", "output": [ "method" ] }, { "id": "task1163-df8ce038ae11421e902a43a3b188efc7", "input": "As such , MPA represents a novel type of inhibitor against RNA guanylyltransferases that inhibits the second step of the catalytic reaction.", "output": [ "finding" ] }, { "id": "task1163-5ad379df7e504b6a9a9e3640f46d49cf", "input": "The ACD feeding treatment supported greater preweaning average daily gain ( 0.59 vs. 0.43 kg/d ) and structural growth than RES feeding.", "output": [ "finding" ] }, { "id": "task1163-d65cdb9d3e4240388e605e5986b7cf54", "input": "which showed that the replication of virus nucleic acid and the formation of the capsid in the cell nucleus were suppressed.", "output": [ "finding" ] }, { "id": "task1163-f3a53b230cb44a7c929c377b828bce21", "input": "The assay of the time of addition limited the drug effect during the first 8 h of infection.", "output": [ "finding" ] }, { "id": "task1163-352b23754fab4e28a30b7da975615085", "input": "ELISA , western blotting and bidirectional immune agar diffusion testing.", "output": [ "method" ] }, { "id": "task1163-9c53005ce15a4577a2d767ac229a507f", "input": "treatment , prognosis , and prevention of the disease.", "output": [ "purpose" ] }, { "id": "task1163-23898c9b754446be81a90df7816f559b", "input": "The clinical data of 34 cases with severe pneumonia were collected.", "output": [ "method" ] }, { "id": "task1163-e42c9c66583a4142b57d260c15b0645d", "input": "The odds of ACD calves being treated for a preweaning disease event tended to be lower than that of the RES calves ( 1.2 vs. 5.2 % , respectively ).", "output": [ "finding" ] }, { "id": "task1163-13f1e3a7ede24f5abdbae580f1a2f142", "input": "Limitations : Studies are observational and findings are mainly based on studies that recruited 47 patient from clinics and hospitals and so may be biased toward more severe cases.", "output": [ "finding" ] }, { "id": "task1163-0870acf4d17f496bb31841c27cedfb76", "input": "ELISAs for IFNs and bactericidal/permeability-increasing protein were performed in both LBW and NBW newborns and in adults ( LBW = 18 , NBW = 18 , Adults = 8 ).", "output": [ "method" ] }, { "id": "task1163-8307b2fff6674771b6fcee4d8562b957", "input": "Objective : This study aimed to evaluate the prevalence and related factors of post-traumatic stress disorder ( PTSD ) symptoms among doctors and nurses who were exposed to H7N9 patients during the H7N9 influenza epidemic.", "output": [ "purpose" ] }, { "id": "task1163-84e36c5aea4c465f89ed396d967ac98b", "input": "Prevention of virus spread is impeded by a lack of basic knowledge concerning viral shedding and transmission potential in individual animals.", "output": [ "background" ] }, { "id": "task1163-825094f6867e49589f67edf8372a6716", "input": "GFP was fused to the carboxy-terminus of S1 for expression of S1-GFP to show expression of recombinant S1 by agroinfiltration of tobacco leaves.", "output": [ "method" ] }, { "id": "task1163-a28e9595bbdb49898ff430a039223b08", "input": "Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues.", "output": [ "background" ] }, { "id": "task1163-9a73d8e9af8e47d08486b5e3b2afa460", "input": "In-hospital mortality rates of ARDS in Taiwan.", "output": [ "finding" ] }, { "id": "task1163-ac12dd257f78456094ef9329d225a225", "input": "use of immune modulators and the role of final boost immunization are discussed in detail.", "output": [ "purpose" ] }, { "id": "task1163-097572dbfb3b44c480c65dafe9f55672", "input": "Postdelivery data were collected from medical records.", "output": [ "method" ] }, { "id": "task1163-db8c629b3ac542d08683e317aaf9daf4", "input": "A total of 93 samples ( 4.7 % ) from 17 genera of bats tested positive.", "output": [ "finding" ] }, { "id": "task1163-1a219de839af4e6e8789b96086791aed", "input": "it is expected that only viral structures in close proximity to activated photosensitizing compounds will be affected.", "output": [ "finding" ] }, { "id": "task1163-2cf5759b898f4478a3d8d503dfe3b36d", "input": "this study conducts a content analysis of 61 relevant journal articles published in 2006-2018.", "output": [ "purpose" ] }, { "id": "task1163-f92051fbf00346c29d1142c0ac918c23", "input": "Serum samples from their dams ( n = 30 ) were also taken 1-week postfarrowing.", "output": [ "method" ] }, { "id": "task1163-cf4edcdfa38b438daf0a4991da4ab0b8", "input": "In this study we showed that CREBregulated transcriptional coactivator 1 ( CRTC1 ) is required for HBV transcription and replication.", "output": [ "finding" ] }, { "id": "task1163-66c355d1b64548779c506302e65bbaf6", "input": "Between April 2011 and November 2012 , 224 patients were included.", "output": [ "method" ] }, { "id": "task1163-b9fd1ee299b74f81be08fec4f2891e30", "input": "and to explore the perspectives and experiences of managers and frontline health workers.", "output": [ "purpose" ] }, { "id": "task1163-e9835581655b47459ef4d7301e72f919", "input": "Each tumor cell or Ad12-transformed hamster cell carries multiple copies of integrated Ad12 DNA.", "output": [ "background" ] }, { "id": "task1163-64760cd23b144db1a4d80c008a7b2111", "input": "OC38 , OC43 , and mouse hepatitis virus ( MHV ) strain A-59 , is described.", "output": [ "background" ] }, { "id": "task1163-8bb856c5a534469bbf10cfdf5c373f42", "input": "Here , we present data for an alternative model whereby RNA viruses evolve high mutation rates as a byproduct of selection for increased replicative speed.", "output": [ "purpose" ] }, { "id": "task1163-3a687c93e99f4eadb7ef9af06f2aeb18", "input": "or 33 % saving from a system without energy saving measures.", "output": [ "finding" ] }, { "id": "task1163-05755a75cf2041e5ae41c00a15330e3a", "input": "Thus the likely scenario is that allergen exposure over the first few years of life induces sensitization ( ie , T H2 cells and IgE antibodies ).", "output": [ "finding" ] }, { "id": "task1163-326054e24ac14319b49ba0766bb8bdc0", "input": "however , was still 20-to-50-fold better than intramuscular inoculation despite the subcutaneous pre-exposure to wild-type VTT.", "output": [ "finding" ] }, { "id": "task1163-31b0355a656a4f028f3670c6cecf63f0", "input": "Objectives : The aim of this study was to investigate the occurrence of viral co-infections in dogs with BP and to assess demographic or clinical variables as well as disease severity associated with viral co-infections.", "output": [ "purpose" ] }, { "id": "task1163-7b5c353d59d24d74825d571f53659904", "input": "Multivariate logistic regression analyses showed the following.", "output": [ "finding" ] }, { "id": "task1163-8b89805f68a543db9356b304cefa5d9f", "input": "Specifically speaking , increasing the successful rate of self-protection does not necessarily reduce the epidemic size or improve the system payoff.", "output": [ "finding" ] }, { "id": "task1163-f361f387c5dc49749b527ed15d7260bf", "input": "and antibodies that specifically bind to the prefusion conformation of RSV F generally demonstrate the greatest neutralization potency.", "output": [ "background" ] }, { "id": "task1163-f75a1ede7b8d4c48bcc6e6e63c5632c9", "input": "researchers have been seeking attractive substrate materials to keep microfluidics improving to outbalance the drawbacks and issues.", "output": [ "background" ] }, { "id": "task1163-6646ef2d643441609fdf65880ea161df", "input": "or travel within the previous 6 months.", "output": [ "background" ] }, { "id": "task1163-ef402b8e3fd94b1d98aa8eb65340f299", "input": "We detected diverse coronaviruses by PCR in wildfowl and wading birds in England.", "output": [ "finding" ] }, { "id": "task1163-1c7c3f9f972c486dad89e8f3965023b6", "input": "The role of wild birds in the epidemiology of IBV is poorly understood.", "output": [ "background" ] }, { "id": "task1163-d8235519d9fb47ceb5ca42f1826bc78d", "input": "Injection of shRNA-1370 into chicken embryo also reduces the replication of avian influenza virus ( AIV ).", "output": [ "finding" ] }, { "id": "task1163-2ac0835c2fa74c2fa5254b3ae7e57870", "input": "The amplicons of positive samples were sequenced for confirmation.", "output": [ "method" ] }, { "id": "task1163-4a5334a92a7b47888e99d267968c261f", "input": "Therefore the objective of the present study was to evaluate the antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni.", "output": [ "purpose" ] }, { "id": "task1163-32d2f6c4b5a54c39a17781c2ed7fe8c7", "input": "and illness burden associated with ARI between December 2012 and March 2013.", "output": [ "purpose" ] }, { "id": "task1163-1e4dc159c80142bfba52aec177794ec8", "input": "HLIUs expended substantial resources in development but must strategize models of sustainability to maintain readiness.", "output": [ "finding" ] }, { "id": "task1163-c2d72449ce8a4641a1c990d1fe5b8bcf", "input": "is imperative and warrants elucidation of its clinical significance.", "output": [ "finding" ] }, { "id": "task1163-48f441c8b54748438ff9ba354e76f8e4", "input": "and minimize the risk to their personnel , trainees and pathologists.", "output": [ "purpose" ] }, { "id": "task1163-f6338d8072f242c39379e842b408a310", "input": "Other finer details pertaining to the mechanism of the pathogen SARS-CoV-2 spread within a given region are implicitly manifested in the exponent parameters derived from the non-linear fitting of the published data on Covid-19 occurrence.", "output": [ "method" ] }, { "id": "task1163-156c199d97b44e0992a476ef79f0da1d", "input": "In this way CDV escapes immune surveillance.", "output": [ "finding" ] }, { "id": "task1163-bb4ea2b5dc364b50a8299e7c4a00a181", "input": "Seven out of ten mutants displayed a wild-type ( wt ) or moderately elevated pH dependence for the conformational change.", "output": [ "finding" ] }, { "id": "task1163-bb5e0f3aff03418395175bf03dafe7d1", "input": "Aim : Bile salt export pump ( BSEP ) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis.", "output": [ "purpose" ] }, { "id": "task1163-92b22a5f7f954130b419810d476d4293", "input": "An overview of the reversible reactions used for the generation of DCLs in protein-templated DCC is given in Scheme 1.", "output": [ "background" ] }, { "id": "task1163-0e3a7a53084348e2955ba0e8d520c184", "input": "from birth through the first 7 days of life.", "output": [ "purpose" ] }, { "id": "task1163-08e3a8a74a5e401ba6ecd64cddbbdf64", "input": "and to assess the available evidence base regarding interventions to reduce such impact.", "output": [ "purpose" ] }, { "id": "task1163-d074970daaee414bbb70193a18f8dc27", "input": "In this chapter , we briefly introduce whole-exome sequencing in the context of genetic approaches to identify host susceptibility genes to viral infections.", "output": [ "purpose" ] }, { "id": "task1163-6c8005f6b28d4e37965e8fdbd4ef4e9a", "input": "In addition , approaches to identifying new biomarkers are also briefly introduced.", "output": [ "purpose" ] }, { "id": "task1163-57a0786ddc91476fa5cc63f83994f058", "input": "Method : We included subjects with suspected MERS-CoV infection and confirmed cases of MERS infection.", "output": [ "method" ] }, { "id": "task1163-fb9bc80d48654495ab7db5a91467566a", "input": "and increased from 2.53 to 19.26 per 100,000 personyears during the study period.", "output": [ "finding" ] }, { "id": "task1163-6d7cb83f43d145ad9aa4977f03fc30ce", "input": "A recombinant Fab that recognizes a neutralizing epitope located in the ( 296 -400 ) region of protein E of dengue virus was obtained from cloned hybridoma cells secreting the mouse monoclonal antibody ( mAb ) 4E11.", "output": [ "method" ] }, { "id": "task1163-ed6e0841a9384a0f909072b36cdd7d47", "input": "Here we showed that ATA indicates a unique mechanism of YopH inactivation due to a redox process.", "output": [ "finding" ] }, { "id": "task1163-a2ea3f22336d49858a9d8bd097df8bb8", "input": "It plays a key role in most cellular processes including immune signaling.", "output": [ "background" ] }, { "id": "task1163-5a4f3154800640829e3ada8a50772350", "input": "including idiopathic pulmonary fibrosis , tuberculosis infection , and respiratory virus infection.", "output": [ "purpose" ] }, { "id": "task1163-68a0329d28314601b782956332d21114", "input": "The primary cause of this CNS disease remains elusive.", "output": [ "background" ] }, { "id": "task1163-84bba888f1af4232924946bdde20b553", "input": "Data are from one experiment with multiple biological replicates for a and b. Statistical analysis for p-values by two-tailed unpaired t-tests.", "output": [ "method" ] }, { "id": "task1163-854fad1106354811936ac9352cf7e1f8", "input": "This review focuses on the interesting properties and potential of this new type of engineered MHC class I molecule.", "output": [ "purpose" ] }, { "id": "task1163-e328497562154f3dbee36a8e37a85cf5", "input": "We showed that p300 was indeed induced by Tat expression and HIV-1 infection and that the induction occurred at the transcriptional level through the cis-acting elements of early growth response 1 ( Egr-1 ) within its promoter.", "output": [ "finding" ] }, { "id": "task1163-147c224762fc4c008fef220168358bff", "input": "which mainly reside at the loop region in all the predicted secondary structures.", "output": [ "method" ] }, { "id": "task1163-7287c9bc98b64030afeb3bde1aed4e2b", "input": "Postweaning body weight and carcass grading information was collected from the veal calves at slaughter once a live weight between 300 and 350 kg had been achieved.", "output": [ "method" ] }, { "id": "task1163-6d29c0dc4f14461ab1fb2e399f5965d9", "input": "we deleted the group-specific genes from the group 2 mouse hepatitis virus ( MHV ) genome via a novel targeted recombination system based on host switching ( L. Kuo , G. J.Godeke , M. J. Raamsman , P. S. Masters , and P. J. M. , J. Virol.", "output": [ "method" ] }, { "id": "task1163-b4246023104a43858dbea7a75db82966", "input": "Gel diluents can have variable viscosities and are `` dropped '' onto chicks with an applicator bar.", "output": [ "background" ] }, { "id": "task1163-18c07c806ccb45709943141e60ab6197", "input": "The biologic basis for the observed protective effect of breast-feeding is reviewed with an emphasis on the mechanisms involved in the development and maintenance of mucosal immunity in general.", "output": [ "purpose" ] }, { "id": "task1163-94efda2875df4803a68eec70cdd02fee", "input": "based on the S1 gene.", "output": [ "background" ] }, { "id": "task1163-9ae0afa0ec5e4136a329c9b8398883da", "input": "with an origin of west African strains in east Africa.", "output": [ "finding" ] }, { "id": "task1163-faf4698cbd1f460ead0f90eac14edf83", "input": "Similar results were obtained for a vaccine made from a Taiwan Group II IBV strain.", "output": [ "finding" ] }, { "id": "task1163-a875e949ed604f569222aaf9c9e0d5ec", "input": "and controls ( n = 128 ) , were included.", "output": [ "method" ] }, { "id": "task1163-fc09154ab8904ab9aca500ef3e947f9a", "input": "Correlation analysis indicated that the base content at the third position of codons affect the degree of codon preference.", "output": [ "finding" ] }, { "id": "task1163-c595c6d5571246f8bd9aa40e75a16c1d", "input": "3 , 7 , 11 and 15 weeks of age.", "output": [ "method" ] }, { "id": "task1163-f091aeda2a6949668acc528c241ec432", "input": "Standardized criteria were set for the assessment of severity of infection and effectiveness of the antimicrobial agent in question.", "output": [ "method" ] }, { "id": "task1163-ffa65aeb1c684c779e05379775c676f5", "input": "We review here the current status of the Korean epidemiologic service and suggest possible supplementation measures.", "output": [ "purpose" ] }, { "id": "task1163-9c5198061bfa4564b3dc54efd7c9bec1", "input": "Inhibition of either APN gene expression or its enzymatic activity severely affects leukocyte growth and function.", "output": [ "background" ] }, { "id": "task1163-073da2e75efa441db9d48f863460080a", "input": "Each patient in the study was monitored for 11-13 months by standard pulmonary function examination.", "output": [ "method" ] }, { "id": "task1163-d490fef2e52e43fa82103ffa706412c3", "input": "and the dynamic effects o f th e length o f lactatio n an d othe r materna l factor s upo n th e concentration s o r functions o f th e component s o f th e system.", "output": [ "background" ] }, { "id": "task1163-ee30baf297394541bd58ee198b6698cb", "input": "there are only few studies on the factors that determine the success and failure of infectious disease response and the responses to administrative and policy aspects.", "output": [ "background" ] }, { "id": "task1163-01832ab948f044659e314a7a91f81b03", "input": "Objective : To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents.", "output": [ "purpose" ] }, { "id": "task1163-9677960428804ad4948cb7d18a977906", "input": "This review presents an overview of nucleic acid probe methodology and its applications in veterinary infectious diseases.", "output": [ "purpose" ] }, { "id": "task1163-87d25d9462364ae49bc92ad333aa2c76", "input": "Here , we evaluated tumor-treating fields-mediated initiation of the macrophage-specific immune response.", "output": [ "purpose" ] }, { "id": "task1163-0fa11792fd7a46bc9bbaea42e71c1bd6", "input": "and by explicitly modelling air travel within the United States ( air travel being relatively insignificant in Great Britain due to its much smaller size ).", "output": [ "method" ] }, { "id": "task1163-0d50e8fbcfa949f18b535cc8224b7032", "input": "userfriendly , replicable , quantifiable and specific , algorithmic-like manner.", "output": [ "finding" ] }, { "id": "task1163-8d5c930276ee4b28bc803b5d39e015c3", "input": "In this study , we integrated sequence information and RNA expression of genes within the QTL to identify mucin 4 ( Muc4 ) as a high priority candidate for controlling SARS-CoV titer in the lung.", "output": [ "purpose" ] }, { "id": "task1163-c733e2481275407da287e306f02ec472", "input": "The spike glycoprotein ( S ) of SARS-CoV was used as the test antigen after the S gene was constructed in the identical genomic location of two vectors to generate vaccine candidates MVTT-S and MVA-S.", "output": [ "method" ] }, { "id": "task1163-534ae533f81b451ca7ea7934b9edde64", "input": "In this paper , we apply two data mining techniques in order to better understand the stability and the possibility of recovery from MERS-CoV infections.", "output": [ "purpose" ] }, { "id": "task1163-d42a9c094ea9441d9cfc01feeeb0ab46", "input": "ribosomal protein L4 ( RPL4 ) and HMBS , RPL4 , respectively.", "output": [ "finding" ] }, { "id": "task1163-966d2d7f7b204019b381a99e1596452c", "input": "the Philippines , on children < 5 years old.", "output": [ "method" ] }, { "id": "task1163-d088fe3dc11c472a93f5c8763e7a1fd8", "input": "The frequency of recombinants is enhanced by conditions that prevent or hinder the minus strand synthesis of a single plus strand segment.", "output": [ "background" ] }, { "id": "task1163-941e029285104bdab6d4d95af821d19e", "input": "Serum eosinophil cationic protein and total IgE levels were measured by ImmunoCAP.", "output": [ "method" ] }, { "id": "task1163-c859a859f2df415499bef8efbfa4355c", "input": "Here , we discuss recent work that employs protein engineering strategies to design immunogens that elicit bNAbs or engineer novel bNAbs.", "output": [ "purpose" ] }, { "id": "task1163-ba475b19fd644bc1be9a5ef413bcc101", "input": "macrophage specific cytochemistry , and phagocytosis.", "output": [ "method" ] }, { "id": "task1163-26b6bb257d8d4c88b69868b0aed91f40", "input": "but when the cholesterol was replenished , NDV infection was restored.", "output": [ "finding" ] }, { "id": "task1163-9f376b2a70e84d84853332ae03ddbbed", "input": "This study examines the international resort park type selection in Taiwan.", "output": [ "purpose" ] }, { "id": "task1163-7c8a932b09e14873bb62c2210c94dac9", "input": "Our data are consistent with the kinetic proofreading model for biosynthetic reactions and suggest that speed is more important than accuracy.", "output": [ "finding" ] }, { "id": "task1163-0263cfde38f443fc8d57dafe2c8f7f45", "input": "In this study , we examined the functional role of the chemokine CXCL1 in contributing to neuroinflammation and demyelination in EAE.", "output": [ "purpose" ] }, { "id": "task1163-0676e7b9dfc947628c42340dbe7c7516", "input": "This chapter is based on semi quantitative risk analysis in order to rank potential health risk transmitted from family dogs to human.", "output": [ "background" ] }, { "id": "task1163-9781985decde44458e346a751613cccb", "input": "which efficiently phosphorylates acyclovir and facilitates incorporation into nascent viral DNA genomes by the HSV DNA polymerase enzyme ; incorporation of acyclovir into viral DNA terminates genome replication ( 3 ).", "output": [ "background" ] }, { "id": "task1163-ed0025d7840543f2aa47e9b339db4392", "input": "Furthermore , we assessed Cohorts D-G were used to evaluate sensitivity of the different platforms.", "output": [ "method" ] }, { "id": "task1163-48d0e260901d44e8a733d690b3e7ddde", "input": "The aim of this study was to evaluate diagnostic indexes of a rapid IgG-IgM combined antibody test for SARS-CoV-2.", "output": [ "purpose" ] }, { "id": "task1163-b51f3cbda22e49e28fb34c932b4d6101", "input": "We discuss the challenges in proving a causal relationship between the presence of a candidate organism and disease.", "output": [ "purpose" ] }, { "id": "task1163-79fe818b54494382b7481b28f26c69d5", "input": "General practitioner ( percentage of influenza-like-illness related patient visits among all patient visits ) and laboratory ( percentage of specimen tested positive ) seem to proportionally reflect the actual disease trends and are less representative of the information environment.", "output": [ "finding" ] }, { "id": "task1163-84c53d42390045d281e365b2011646c7", "input": "Methods : This study included an index case and all HCW contacts.", "output": [ "method" ] }, { "id": "task1163-f2650ad21eb84d50979ea4b58722c863", "input": "The number of total cases was determined by the maximum log likelihood estimation.", "output": [ "method" ] }, { "id": "task1163-0660b6d5eef64c6f9c3b6cc4462971fc", "input": "schools and workplaces , and the wider community.", "output": [ "method" ] }, { "id": "task1163-edd480e1593f49b88a28d8ffec57b4f4", "input": "important questions have remained unanswered.", "output": [ "background" ] }, { "id": "task1163-ea632169da4742928d931edc00a1dd42", "input": "The genome of bacteriophage q ~ 6 is composed of three unique segments of double-stranded RNA packaged within a procapsid.", "output": [ "background" ] }, { "id": "task1163-b215b7a47d91487e8ce0bdf74493766a", "input": "19 Objectives : Development and validation of a single-step and accurate reverse transcriptase loop-20 mediated isothermal amplification technique ( RT-LAMP ) for rapid identification of SARS COV-2 21 relative to commercial quantitative reverse transcriptase real-time PCR ( qRT-PCR ) assays to allow 22 prompt initiation of proper medical care and containment of virus spread.", "output": [ "purpose" ] }, { "id": "task1163-0927b5c456eb4c21b45d7e8295b8f518", "input": "especially its wobble interaction , to constrain the incoming aminoacyl-tRNA to the correct reading frame.", "output": [ "purpose" ] }, { "id": "task1163-ab7e2a321425481fac05b0727091634d", "input": "were injected intraperitoneally into these mice to produce ascitic fluid containing monoclonal antibodies.", "output": [ "method" ] }, { "id": "task1163-ec85ef664efa482ab700b5a3eec5ff83", "input": "We have shown by N-glycanase digestion that LCMV strain Arm-4 bears five oligosaccharides on GP-1 and two on GP-2.", "output": [ "background" ] }, { "id": "task1163-6a562b0f1af44e3c82e4afac889d3113", "input": "Missouri and Chicago , Illinois notified the Centers for Disease Control and Prevention ( CDC ) about increased numbers of pediatric patients hospitalized with severe respiratory illness ( SRI ).", "output": [ "background" ] }, { "id": "task1163-6fdd2ef353394947b8d563cc2b3557e6", "input": "To illustrate our metrics , phylogenetic trees of 18 Eutherian mammals from comparison of their mtDNA sequences and 24 coronaviruses using the whole genomes are constructed.", "output": [ "method" ] }, { "id": "task1163-0a1573bef0514fa5b8da76c4cd6e6eb3", "input": "Influenza and Other Respiratory Viruses 5 ( 1 ) , 1-5.", "output": [ "finding" ] }, { "id": "task1163-1a6c0ec245e04ccbbc2aa110f348ea64", "input": "The QAC being tested is an antibacterial film that is sprayed onto a surface and can remain active for up to 8 h.", "output": [ "method" ] }, { "id": "task1163-c62795baba4d47e898f67003fabeae00", "input": "depression and post-traumatic stress disorder ( PTSD ) frequencies.", "output": [ "purpose" ] }, { "id": "task1163-c6af7ccd7796497e9d7010ac923b8c62", "input": "diagnosis code for a state-required reportable communicable disease were matched to surveillance records.", "output": [ "method" ] }, { "id": "task1163-2eab690c83ba4c4ba41d27aae612112f", "input": "but not the AM , strain.", "output": [ "finding" ] }, { "id": "task1163-c0e3534c481b45868d7b536163f59735", "input": "This is important to focus on screening and detection to this patient population.", "output": [ "finding" ] }, { "id": "task1163-c930c14ff2634ec885a10b2212afe1c1", "input": "pharmacological and toxicological properties of Pelargonium sidoides as well as the potential role of plant biotechnology in its conservation.", "output": [ "purpose" ] }, { "id": "task1163-af5bde8eb00a49b5afdeaa77bd1739f3", "input": "We assessed the effectiveness of syndromic screening at departure and/or arrival & traveller sensitisation to the COVID-2019-like symptoms with the aim to trigger rapid self-isolation and reporting on symptom onset to enable contact tracing.", "output": [ "method" ] }, { "id": "task1163-21544613e4694e0a80514c3d029ea30f", "input": "In addition , important hemostatic alterations due to the infection suggest a chronic intravascular consumption coagulopathy.", "output": [ "finding" ] }, { "id": "task1163-9125298f72ab44d9af9af2aa178bf510", "input": "The objective of this study was to determine whether pet owners noticed and retained the message of a poster with an antimicrobial stewardship message placed in veterinary clinic exam rooms.", "output": [ "purpose" ] }, { "id": "task1163-2f25bd61a77840c3b75de4c1f6591680", "input": "in order to identify limitations and knowledge gaps in developing of new methods.", "output": [ "purpose" ] }, { "id": "task1163-aff7840a4b624acfa1f80d06683fe71d", "input": "ACE2 activators and angiotensin II antagonist.", "output": [ "purpose" ] }, { "id": "task1163-cc90f53c59b14439a22c4f9a6dbd44e8", "input": "Methods : Outpatients with ARI were assayed for presence of 18 viruses using multiplex reverse transcriptase polymerase chain reaction ( MRT-PCR ) to simultaneously detect multiple viruses.", "output": [ "method" ] }, { "id": "task1163-29f5cff3158b42cdbfc90e49a41f26bf", "input": "EF-Tu , EF-G , and initiation factors were prepared as described ( 2-5 ).", "output": [ "method" ] }, { "id": "task1163-f8c6e45c192948e5ab2a35be1ae5be8e", "input": "Light-and quantitative electron-microscopic evaluation showed that epithelia exposed to 1 ppm ozone in air exhibited loss of ciliated cells and ciliated cell damage.", "output": [ "finding" ] }, { "id": "task1163-d6c8b1dfabb744c28a727ceb5b84b3f8", "input": "purify and characterize soluble and secreted versions of several viral envelope glycoproteins which have been successfully used as antigens to capture and isolate human phage-displayed monoclonal antibodies.", "output": [ "purpose" ] }, { "id": "task1163-7612fdbdc34c4c77bea2f567f6c88b0b", "input": "Co-detection of CIV and CRCoV was represented the highest proportion and most often found with other CIRD viruses.", "output": [ "finding" ] }, { "id": "task1163-cbcfb681e8b0432d909f717e0e33d71c", "input": "† This manuscript does not refer to patients undergoing allogeneic hematopoietic stem cell transplantation.", "output": [ "finding" ] }, { "id": "task1163-f384590e3fa549f2a47be60214a1747f", "input": "expert-curated accounts ( e.g. , ProMED Mail ) , and validated official alerts.", "output": [ "method" ] }, { "id": "task1163-462114a827354b378fdd573150219edd", "input": "The polyproteins of the strains differed in eight amino acids.", "output": [ "finding" ] }, { "id": "task1163-07f7424338f94b1cae40f227b35b8d94", "input": "Eighty medical staff contracted SARS in 2003.", "output": [ "method" ] }, { "id": "task1163-e211bf30d8ce4fa382866e2f24b33202", "input": "development of new anti-HIV agents is urgently needed.", "output": [ "background" ] }, { "id": "task1163-2dae92c4b5c541a3b689979f8f22f6f6", "input": "A total of 177 faecal samples from pups with enteritis were analysed by a PCR and n-PCR specific for CCV.", "output": [ "method" ] }, { "id": "task1163-86323017cc4747cb863247bbdbb91653", "input": "Procalcitonin discriminated between typical bacteria and the combined group of viruses and atypical bacteria with an area under the ROC curve of 0.79 ( 95 % CI , .75-.82 ).", "output": [ "finding" ] }, { "id": "task1163-d2599f829a0047368938ba3172716477", "input": "in parallel with measurements of total bacterial count and haemoglobin presence.", "output": [ "purpose" ] }, { "id": "task1163-11d774f8b6dd4f2d92c192a78e2bc486", "input": "Both hinder proper allocation of a premium for different view obstruction levels for high-rise high-density urban environments.", "output": [ "background" ] }, { "id": "task1163-97007ff52eb74670a657aa6bf7b27e52", "input": "Of note , 70 IFN-signature genes were found to be significantly down-regulated in LBW compared to NBW newborns.", "output": [ "finding" ] }, { "id": "task1163-6743bb33b31f44828fa4b5886a419ad2", "input": "In this study , we amplified the 1.2 kb HE gene from the HTV genome using long RT-PCR and sequenced the amplicon directly.", "output": [ "method" ] }, { "id": "task1163-45aa9681d43d4158916f4363a5fe8242", "input": "Furthermore , it also inhibited a CXCR4-tropic replication-competent strain of HIV-1 subtype B virus.", "output": [ "finding" ] }, { "id": "task1163-93172660b1ca424193d6b13ef06af1cc", "input": "while the viral products of all downstream open reading frames are derived from subgenomic mRNAs.", "output": [ "background" ] }, { "id": "task1163-234f43de9f944cc7921d18ea7247adac", "input": "and produced by gene synthesis ( Genscript ).", "output": [ "method" ] }, { "id": "task1163-2cb1200f915c4c579f2e1ca9cd7938e9", "input": "The aim of our studies was to determine whether ADAM17 depletes ACE2 levels in pancreatic islets and ␤ - cells.", "output": [ "purpose" ] }, { "id": "task1163-46b3f5f9898d4b9ebf12953c10aa5e12", "input": "which is present in the F cleavage site of neurovirulent strain Beaudette C ( BC ).", "output": [ "method" ] }, { "id": "task1163-3a24569d537741a3a0038b6ebc6760eb", "input": "Male C57BL/10 mice were used as donors.", "output": [ "method" ] }, { "id": "task1163-4b45023aa7904e0d837bd2ac1c54d69f", "input": "Optimization of each key step is extensively discussed and simplified protocols for library panning and Fab production are also described.", "output": [ "purpose" ] }, { "id": "task1163-243c307996444379b70351344b117a52", "input": "followed by a detailed discussion of the application of food technology ethics in industrial contexts.", "output": [ "purpose" ] }, { "id": "task1163-4110f6f76def414f81b8f82de18d0562", "input": "Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9.", "output": [ "background" ] }, { "id": "task1163-8747536599a24712b1d66cf124a96905", "input": "observational , and multicenter study conducted in 16 tertiary PICUs in Turkey includes a total of 302 children with viral cause in the nasal swab which required PICU admission with no interventions.", "output": [ "method" ] }, { "id": "task1163-f7b8d7d4dde844408a4a902f08611ab2", "input": "which was the same as the expected results.", "output": [ "finding" ] }, { "id": "task1163-867dfbce46f74529a59ecb5de5bd08f6", "input": "BetaCoV _ RaTG , and BatSARS-like Cov.", "output": [ "finding" ] }, { "id": "task1163-b1270ddfe8db489985be3fb8823b1e6d", "input": "37 making it an attractive drug target for this virus 5,6.", "output": [ "background" ] }, { "id": "task1163-4fb2b1054cc448649b7d50cb6c5ed559", "input": "one to three weeks ahead.", "output": [ "method" ] }, { "id": "task1163-cc2b0424e0a64dd5aee17952b9daf4bf", "input": "The resulting activation of the adaptive response is a critical step to resolution of injury or infection and is key to survival.", "output": [ "background" ] }, { "id": "task1163-8bbd56178f4f4fc5a421cbbc72f8f494", "input": "Amino acids substitutions were analysed.", "output": [ "method" ] }, { "id": "task1163-9389b766e4464a558b8d69bfe48491fe", "input": "Common six viruses associated with CIRDC were detected in both groups with CIV and CRCoV being predominantly found.", "output": [ "finding" ] }, { "id": "task1163-c066f875740c465cbd8e2463aa8a7801", "input": "and novel non-mechanical delivery methods.", "output": [ "background" ] }, { "id": "task1163-e462f199c1df458cae095b9400f78242", "input": "No reuse allowed without permission.", "output": [ "finding" ] }, { "id": "task1163-dd8eaef6e35d490488471ecad642cf9f", "input": "miscellaneous drugs , natural products , herbal and repurposing drugs.", "output": [ "purpose" ] }, { "id": "task1163-a2d7efd56a834b18b7f7e156b3949dc7", "input": "The first doctor to report this new disease was an ophthalmologist : this exemplifies the role of ophthalmologists in an infectious disease pandemic.", "output": [ "background" ] }, { "id": "task1163-14b5828e45f64a86bce2b2bef2de1d39", "input": "we analyzed both global and novel Japanese strains detected during 2013-2017.", "output": [ "method" ] }, { "id": "task1163-536dbdd6b1a84ff0950ed3c3cbecc738", "input": "but also in large animal models.", "output": [ "background" ] }, { "id": "task1163-966ede3575c949b1803387342d328193", "input": "We conclude that the C58 cell line can be used to generate continuously growing monoclonal T-cell reagents of sufficient stability using both intra-and inter-species hybridisation.", "output": [ "finding" ] }, { "id": "task1163-1d6c5ca9deb546d48cc98bef4dd1645d", "input": "In this study we investigated the role of XendoU homologs in Drosophila melanogaster.", "output": [ "purpose" ] }, { "id": "task1163-a058727630e74ce895b8f479ce09e9c6", "input": "epidemiologists have recognized that ` superspreading ' hosts play a key role in disease epidemics.", "output": [ "background" ] }, { "id": "task1163-c643897619154921909f0bd57493a4b3", "input": "we investigated whether neutralizing mAbs that are highly homologous to those of humans ( human-like ) could be generated.", "output": [ "purpose" ] }, { "id": "task1163-54d490a004f7495cb5377cb5be72fc64", "input": "and respiratory rate 28 breaths per minute.", "output": [ "finding" ] }, { "id": "task1163-d93e8f61dcf74ab597bf5b2f5021e0dd", "input": "camel exposure , and exposure to untreated food products.", "output": [ "finding" ] }, { "id": "task1163-5648053f8a4c47f395febd1384aa4bf5", "input": "# * P < 0.05 vs. CI.", "output": [ "finding" ] }, { "id": "task1163-7d494fdbd87a47e19ce1a727a83e3765", "input": "This activity can be inhibited by the viral NS1 protein.", "output": [ "finding" ] }, { "id": "task1163-b8b455c2264444dfa0404d231722786f", "input": "In the present studies , we report the cloning and structural characterization of the HFGL2 gene and its functional role in human fulminant hepatitis.", "output": [ "purpose" ] }, { "id": "task1163-d75cd1ff8f4f4829a259a4c627aae401", "input": "Objective : To investigate the prevalence of respiratory syncytial virus ( RSV ) and rhinovirus ( and its species ).", "output": [ "purpose" ] }, { "id": "task1163-23aac675ef7d408bafd4e9db863b7f41", "input": "is the highest frameshifting efficiency recorded to date for any virus.", "output": [ "finding" ] }, { "id": "task1163-51359865bb9c4a1eaef3a498d6e5d1f0", "input": "Infection of the X-SCID rats with RatPyV2 and Pneumocystis carinii is a potential model for coinfection pathogenesis and treatment options during transplant preclinical studies.", "output": [ "finding" ] }, { "id": "task1163-8fb22440bb994dfe92f0138acf02b39a", "input": "Here we discuss in detail how intracellular pathogens exploit dendritic cells and evade degradation by altering or evading autophagy.", "output": [ "purpose" ] }, { "id": "task1163-25f8e8aa56e14de689e2556bbf40ed2c", "input": "a non-immunosuppressive cyclosporin A-analog , inhibit the replication of four different coronaviruses , including MERS-and SARS-coronavirus.", "output": [ "purpose" ] }, { "id": "task1163-a4490e0f3c3c46f69b422627bcf84d52", "input": "sapiens-tc/GIN/2014 / Makona-C05 and treated with sufficient SAB-139 at 1 day ( n = 6 ) or 3 days ( n = 6 ) postinfection survived versus 0 % of controls.", "output": [ "finding" ] }, { "id": "task1163-3d5c8fe0b6144741a8754fbdec3d45d3", "input": "The PHE-CoV DNA vaccine was constructed by subcloning the S1 gene of PHE-CoV into the pVAX1 vector to create the recombinant plasmid pV-S1.", "output": [ "method" ] }, { "id": "task1163-fa564bf955ab419e8736912cd47a3912", "input": "affecting more than 3500 human cases and resulting in a huge economic loss ( 17 , 18 ).", "output": [ "background" ] }, { "id": "task1163-a0d37cb6857a4d1ab8712f68a651bbf3", "input": "This review examines the expression strategies that have been used to this end and focuses on the distinguishing features between those that make use of single polycistronic baculovirus ( co-expression ) and those that use multiple monocistronic baculoviruses ( co-infection ).", "output": [ "purpose" ] }, { "id": "task1163-03459fb3c69f473caae9a4000c6d356c", "input": "HA0 , to the fusion-permissive form , HA1-S-S-HA2.", "output": [ "finding" ] }, { "id": "task1163-32e051ac8a9f43c08002a02065b4782b", "input": "This study examined whether an infection with porcine reproductive and respiratory syndrome virus ( PRRSV ) potentiates respiratory signs upon exposure to bacterial lipopolysaccharides ( LPS ).", "output": [ "purpose" ] }, { "id": "task1163-3ee514f2cc6949c6826358a631e128f9", "input": "author/funder , who has granted medRxiv a license to display the preprint in perpetuity.", "output": [ "finding" ] }, { "id": "task1163-e7d681c2f5a34a81a911b6bab7369529", "input": "Musca domestica ( Linnaeus 1758 ) , under laboratory conditions.", "output": [ "purpose" ] }, { "id": "task1163-cc816c4c2ba04d3693af414f01bb8d66", "input": "Furthermore , this information can be used to identify possible cross-reactivities among proteins due to similarities in their binding sites.", "output": [ "finding" ] }, { "id": "task1163-a2cbc0b9c8914d06a9914cd636f8a96f", "input": "Polycythemia and hyperviscosity altering blood flow and infectious agents are also implicated.", "output": [ "background" ] }, { "id": "task1163-0ee27ea948bc45a482ff3d6bb53090bb", "input": "This study is designed to conceptually propose and empirically examine a theoretical model for restaurant diners ' self-protective behavior in response to an epidemic crisis.", "output": [ "purpose" ] }, { "id": "task1163-eb111f0496084be092c5438a0780e494", "input": "Background : Many outbreaks of Middle East respiratory syndrome coronavirus ( MERS-CoV ) have occurred in health care settings and involved health care workers ( HCWs ).", "output": [ "background" ] }, { "id": "task1163-4a3839a5dde74bb299d81017d090a031", "input": "Genetic PAP ( GPAP ) is caused by mutations in genes encoding surfactant proteins or genes encoding a surfactant phospholipid transporter in alveolar type II epithelial cells.", "output": [ "background" ] }, { "id": "task1163-a8bea442ef2d4adea468528a4f31469c", "input": "Study design : Two hundred and three retrospective and 36 prospective respiratory samples were tested by all three assays.", "output": [ "method" ] }, { "id": "task1163-c1c8061fcbae46f39ad34160afb4b0e3", "input": "which utilizes porcine aminopeptidase N ( pAPN ) as a functional receptor.", "output": [ "finding" ] }, { "id": "task1163-80a67b865dac4575b8f98f3bffb7de03", "input": "However , respondents with pre-outbreak respiratory problems and diabetes did not more often take preventive measures.", "output": [ "finding" ] }, { "id": "task1163-0fccd569d1e64aadb2d47fd3b95ab7d4", "input": "This protocol describes how to determine whether CNS protection observed after drug intervention is a consequence of attenuating CNS-infiltrating immune cells or blocking death of CNS cells during inflammatory insults.", "output": [ "purpose" ] }, { "id": "task1163-2a22fadecbe247918c070eca43a764df", "input": "in Argentina , mostly detected in dairy husbandry systems.", "output": [ "background" ] }, { "id": "task1163-a52ab3182309403eb4d50ca4b7ab12ea", "input": "Kingdom of Saudi Arabia ( KSA ).", "output": [ "background" ] }, { "id": "task1163-9d9bd3143c2c46398f029bb29ab2da3d", "input": "Workshop participants recommended enhanced international harmonization and cooperation and closer collaborations between human and veterinary researchers to expedite progress.", "output": [ "finding" ] }, { "id": "task1163-316f82e8482945198586b782e3111d2e", "input": "Mutating the G _ GUU _ UUU shift site to inhibit frameshifting results in an attenuated virus with reduced growth kinetics and a small-plaque phenotype.", "output": [ "finding" ] }, { "id": "task1163-2ba5f0ac127f4cc09ddbb80751437e6a", "input": "66 consistent with its theoretical molecular weight 33796.8 Da.", "output": [ "background" ] }, { "id": "task1163-5aa5571db2144fcea7aa17e0a5d8f56b", "input": "transaminitis , and rapid-onset respiratory failure with acute kidney injury ( AKI ).", "output": [ "background" ] }, { "id": "task1163-b530228f7f5b49f1845c8cd7547c95d6", "input": "with focus on classical methods used as well as more recent molecular methods.", "output": [ "purpose" ] }, { "id": "task1163-8b14b19888a545e39983d2a07baac42e", "input": "Therefore , G-quadruplexes have emerged as a new class of molecular targets for drug development.", "output": [ "background" ] }, { "id": "task1163-13408d02c428439ebea22a1346915b2c", "input": "Here , we show that dualfunction hemagglutinin-esterase envelope proteins of nidoviruses distinguish between a variety of closely related O-Ac-Sias.", "output": [ "purpose" ] }, { "id": "task1163-e8dceff9d066449a97dae77db9ccd787", "input": "The purpose of this network is to provide timely and accurate laboratory results to the Global Polio Eradication Initiative.", "output": [ "purpose" ] }, { "id": "task1163-cda864716adb463bb9d47186465972d3", "input": "are established infectious agents of humans and cattle , respectively.", "output": [ "background" ] }, { "id": "task1163-19e54f410d9b4942be7f8d4462317c37", "input": "All samples were subjected to real-time reverse-transcription polymerase chain reaction ( RRT-PCR ) for detecting H9-Specific viral RNA.", "output": [ "method" ] }, { "id": "task1163-8332bcd3d6bd45ed9e77d9a4bca21cd8", "input": "optimize treatment , and develop new therapeutics.", "output": [ "finding" ] }, { "id": "task1163-50f16ddf2e5e498889a01118d1f43898", "input": "Nonstructural protein σ1s is implicated in cell cycle arrest and apoptosis in reovirus-infected cells but is completely dispensable for reovirus replication in cultured cells.", "output": [ "finding" ] }, { "id": "task1163-4abe5a45829a4aa1ae1b400c25e6eb91", "input": "Overlapping peptides covering the entire NiV-G protein were used to identify major histocompatibility complex class I/II-restricted T cell responses in type I interferon receptor-deficient ( IFNAR − / − ) mice after vaccination with the MVA-NiV-G candidate vaccines.", "output": [ "method" ] }, { "id": "task1163-29d0f125508f4643abae265c196256c0", "input": "On this basis , recommendations are made to improve the control of aerosol-transmitted infections in hospitals as well as in the design and construction of future isolation facilities.", "output": [ "purpose" ] }, { "id": "task1163-d4a0faa52dbe4a72a30e1d04e8bdee8b", "input": "On otologic examination , a few vesicles were observed in the external auditory canal of the right ear with a normal tympanic membrane.", "output": [ "method" ] }, { "id": "task1163-2efd1d24af044dc9814abb0984e9f968", "input": "Polymerase chain reaction was performed for 13 respiratory pathogens.", "output": [ "method" ] }, { "id": "task1163-8a2ccc41524743edbe145e029fceb198", "input": "Clara cells are non-ciliated , secretory bronchiolar epithelial cells that serve to detoxify harmful inhaled substances.", "output": [ "background" ] }, { "id": "task1163-a2aec56ea1bb4abcbdaacf574257e23f", "input": "These should complement current efforts to block viroporin channel activity.", "output": [ "purpose" ] }, { "id": "task1163-db550c7fcf1242c29395e8c79d450fc1", "input": "Meanwhile , hepatitis A virus appears to be most closely related with developed land use in dense population areas.", "output": [ "background" ] }, { "id": "task1163-3eee32b75da242cea70ec422b3973464", "input": "Here we review the nature of TMD sorting determinants and how they may dictate transmembrane protein localization and transport.", "output": [ "purpose" ] }, { "id": "task1163-4e68bb2062274348941420e4ecc4b290", "input": "A biopsy of the erosive lesions was not performed.", "output": [ "method" ] }, { "id": "task1163-4dde0580606c4467b2850444570673cb", "input": "we performed video-assisted thoracoscopic surgery ( VATS ) to determine the cause of the diffuse lung infiltration.", "output": [ "method" ] }, { "id": "task1163-f3496c973a0441e5b3f2f7ccb52a3a61", "input": "Medication history was not associated with an increase or decrease the likelihood of the infection.", "output": [ "finding" ] }, { "id": "task1163-b3c0ed2201a54399b8c28075c5b43a21", "input": "During infection , NS4B induces elongation of mitochondria , which physically contact CMs.", "output": [ "finding" ] }, { "id": "task1163-b0182a9ac4df454287079c35200046de", "input": "This paper evaluates the performances of common constant air volume ( CAV ) system and variable air volume ( VAV ) system when carbon dioxide and particles are significantly present in outdoor environment.", "output": [ "purpose" ] }, { "id": "task1163-5d43ddc992c14890b03ed0e12f305b2f", "input": "We used a regression model to examine the impact of influenza on death rates in tropical Singapore for the period 1996-2003.", "output": [ "background" ] }, { "id": "task1163-68ea4ee561534b28a4f9b6f8d752ea43", "input": "such as intravenous immunoglobulin ( IVIG ).", "output": [ "finding" ] }, { "id": "task1163-0030430aebfd42618636d7714a14eb74", "input": "In this paper , we review fully integrated lab-on-chip systems for blood analysis of viral infectious disease.", "output": [ "purpose" ] }, { "id": "task1163-d2af4254a8544bbdb6ca9264de61416c", "input": "Compared to controls , treated kittens had lower levels of a 1 - globulins and higher mean values of g-globulins and immunoglobulins.", "output": [ "finding" ] }, { "id": "task1163-3f1a828508e043f0aec00b461321f348", "input": "These results are comparable with observations in the United States and subtropical Hong Kong.", "output": [ "finding" ] }, { "id": "task1163-197f149efa844fd0814dab520a7abe95", "input": "Pneumatosis intestinalis can be demonstrated radiographically.", "output": [ "background" ] }, { "id": "task1163-a9b2e491e3bf400ba76048d3a6fa720d", "input": "diverse and comprehensive discussions consisting of identification and securement of resources for disaster management ; information sharing ; timely and accurate communication and coordination with relevant agencies ; networking processes that organically link disaster prevention and preparedness during non-disaster times ; response during a disaster ; recovery after a disaster ; and learning from the experience of the disaster ; are needed for effective disaster response.", "output": [ "finding" ] }, { "id": "task1163-0348b4e5fa81471ab068c240f51f8029", "input": "Five laboratories participated in the RT ( seven pipelines were tested ).", "output": [ "method" ] }, { "id": "task1163-c7947c860d2d4f4488a48d88fe119afc", "input": "In addition , SAT05f significantly inhibit IFN-α production from purified human plasmacytoid cells ( pDCs ) stimulated by CpG ODN.", "output": [ "finding" ] }, { "id": "task1163-3c0010079f03473c878217b6776b9df4", "input": "the shale revolution and the gradual shift towards low-carbon sources and renewables.", "output": [ "background" ] }, { "id": "task1163-01b9ae9570c648c4895df47d5d4fa772", "input": "and open novel perspectives for the development of heparan sulfate-targeting therapeutic approaches for these emerging infections.", "output": [ "finding" ] }, { "id": "task1163-898fdc2848224a3c95ba144a260178b5", "input": "Reovirus likely inhibits the IFN response by at least 3 virus strain-specifi c mechanisms.", "output": [ "finding" ] }, { "id": "task1163-48acc1e6972e4cc8aca2faec9cd83798", "input": "as they harbour transcripts circumstantially excluded from the translationally active pool.", "output": [ "background" ] }, { "id": "task1163-fbecc9b84bd34be0bd612e0c4d7d423f", "input": "The functionalisation of microbeads with oligonucleotides has become an indispensable technique for high-throughput aptamer selection in SELEX protocols.", "output": [ "background" ] }, { "id": "task1163-18ee0c0a76c24ef280a0c5642920b79b", "input": "RPL4 and HPRT1 , HMBS were the two most stable reference genes for POT , and POT+N , respectively.", "output": [ "finding" ] }, { "id": "task1163-cc3ae9ff8439488ca6d39f7eab044e56", "input": "We also found that DnaG strongly binds native and in vitro transcribed rRNA and enables its polynucleotidylation by the exosome.", "output": [ "finding" ] }, { "id": "task1163-59c0d7273af24aef902974ba27634837", "input": "This study presents a state-of-the-art review of the use of an expert decision analysis process in land-use planning and resort type selection in particular.", "output": [ "purpose" ] }, { "id": "task1163-42693c3ca4784a2086be913f83965f4f", "input": "Both focus-forming assays and percent infection by flow cytometry revealed overlapping replication levels in two different cell types.", "output": [ "finding" ] }, { "id": "task1163-f9fdf2ac04e4454e97acc370ed4fb525", "input": "which was validated as an independent criterion of disease classification in another 92 hospitalized patients with COVID-19.", "output": [ "finding" ] }, { "id": "task1163-9957fb72b2cc4b5b9cf109106782c922", "input": "This chapter reviews the structural and functional aspects of ACE and ECE and will particularly focus on these enzyme homologues in invertebrates.", "output": [ "purpose" ] }, { "id": "task1163-09743353a5394c4e9a480be36bcb1cb4", "input": "directly or indirectly , these concepts.", "output": [ "background" ] }, { "id": "task1163-29bcdb1d29ed4e66a6fd1c83345be672", "input": "SARS-CoV 7a and human SGT interaction was identified using a two-hybrid system screen and confirmed with interaction screens in cell culture and cellular co-localization studies.", "output": [ "method" ] }, { "id": "task1163-fadf1e15cdec4714ac03082b6f0146cf", "input": "Furthermore , the VP6 gene of HuRVC/H28/2013 / India shows the highest similarity to a recently-reported human-like porcine RVC ( PoRVC/ASM140/2013 / India , KT932963 ) from India suggesting zoonotic transmission.", "output": [ "finding" ] }, { "id": "task1163-43635e477ce34920a497c0c7096331f5", "input": "serving a diminishing number of overseas countries and cities.", "output": [ "background" ] }, { "id": "task1163-86b17a516c2e4fd29781842ae56cb997", "input": "the deer mouse ( Peromyscus maniculatus ).", "output": [ "method" ] }, { "id": "task1163-dafbe429a8d6478e9465ed215b4d4f03", "input": "respectively , might be added.", "output": [ "background" ] }, { "id": "task1163-b8bf76ef33354f6fa44578b1a690370f", "input": "Additionally , it is important that reactions are chemoselective to avoid cross reactivity with functional groups of the building blocks or the protein ( e.g. , lysine residues at the surface of the protein ).", "output": [ "background" ] }, { "id": "task1163-65a83f82c7d040d1bfd42c732e7d2c52", "input": "Time-dependent state variables 58 are taken to describe the compartments of the two populations.", "output": [ "method" ] }, { "id": "task1163-5b555071c19b4808bfce6f4554616c1f", "input": "We wished to evaluate the use of DFA for epidemiological studies with a long-term observation of respiratory viruses that includes both respiratory picornaviruses and hMPV.", "output": [ "purpose" ] }, { "id": "task1163-3d0c1c893c01447299e6d44c43fafff1", "input": "However , these exhibit substantial cytotoxicity.", "output": [ "background" ] }, { "id": "task1163-0e15a805256a4015b32c43783628403f", "input": "we identified potential risk factors using predictive classification tree and random forest ensemble models.", "output": [ "finding" ] }, { "id": "task1163-be7a4fe570334c988f1e3456cd829c57", "input": "The predominant cell types in epithelia exposed to oxygen plus ozone were serous cells and metaplastic cells.", "output": [ "finding" ] }, { "id": "task1163-4dea9d35f5bb46fa9d7efd50ef5806b1", "input": "Here , we review advancements in each of these areas that show promise for increasing the immunogenicity of DNA vaccines.", "output": [ "purpose" ] }, { "id": "task1163-b013cb86285e4431b2253492b415bb86", "input": "The APMVs presently are being considered as human vaccine vectors.", "output": [ "background" ] }, { "id": "task1163-9230d357e8894e09a0c56b34c8f19990", "input": "We discuss crisis prevention and management during the first 3 months of the severe acute respiratory syndrome ( SARS ) outbreak in Singapore.", "output": [ "purpose" ] }, { "id": "task1163-87eb49362eb045d7861e3210c849ca50", "input": "who had contact with an ill camel shortly before symptom onset , died on March 26.", "output": [ "background" ] }, { "id": "task1163-0fadd516b1924258b05e973365ccb9b3", "input": "as can be seen in the ongoing Ebola epidemic in West Africa.", "output": [ "purpose" ] }, { "id": "task1163-eb1ff6d47c7948848f37d654bfda9bac", "input": "cancer classification studies , and patient stratification in drug development.", "output": [ "purpose" ] }, { "id": "task1163-f4128bd52df44c98845a02024a39b877", "input": "Experimental evolution of 3D G64S under selection for replicative speed led to reversion and compensation of the fidelity phenotype.", "output": [ "finding" ] }, { "id": "task1163-af6e6e1e84584e0387fc1ae7797076e3", "input": "with a particular focus on susceptibility to viral infection.", "output": [ "background" ] }, { "id": "task1163-baf77c03de1f4d4aac9ed1210eb59182", "input": "and speculate on how they may be related.", "output": [ "purpose" ] }, { "id": "task1163-06079456d69e4ab0a1defc00404e0cdd", "input": "we examined the effects of GM-CSF on cytokine production by glial cells.", "output": [ "method" ] }, { "id": "task1163-f9df303ebdfd4399990536d7ffed1bae", "input": "Our data on the N-and O-glycosylation is strengthened by extensive manual interpretation of each glycopeptide spectra in addition to using bioinformatics tools to confirm the complexity of glycosylation in the spike protein.", "output": [ "finding" ] }, { "id": "task1163-5c57d334fd81423aaccaeaef379c52f2", "input": "continually sampling their local environment.", "output": [ "background" ] }, { "id": "task1163-2ecf7e2da204463987cd68c5a159609b", "input": "and to provide recommendations for expanding the use of these techniques.", "output": [ "purpose" ] }, { "id": "task1163-e1aeeb671ecf44f29ba8feefe0d5adaf", "input": "The objectives were to determine the median infective dose ( ID 50 ) of Cryptosporidium parvum and to describe the dose-response relationship including associated clinical illness in experimentally challenged dairy calves.", "output": [ "purpose" ] }, { "id": "task1163-6292cf5664104fdcbfe8ad429e259fe3", "input": "we collected case and control samples and performed pathological and diagnostic analyses.", "output": [ "method" ] }, { "id": "task1163-cb0abbb685c2402a96adef2eaa847e00", "input": "Here we comment on current advances in the application of P. pastoris for the synthesis of recombinant subunit vaccines.", "output": [ "purpose" ] }, { "id": "task1163-b175d3d5971b43a48284f15a5d5f6c4f", "input": "Here , we review the literature focusing on different SARS-CoV 3CLpro expression constructs and assays used to measure enzymatic activity.", "output": [ "finding" ] }, { "id": "task1163-1c68974337d5448f921b4cda5ce12061", "input": "and discuss evidence suggesting that IFITM3 adopts multiple membrane topologies involving at least one intramembrane domain in its antivirally active conformation.", "output": [ "purpose" ] }, { "id": "task1163-c92a5d8050164ca58988c5427eae21f4", "input": "Objective.", "output": [ "purpose" ] }, { "id": "task1163-ffc13b24e5d74fc3982428a0b97ff91c", "input": "but were generally low even for diseases with great public health importance and opportunity for interventions.", "output": [ "finding" ] }, { "id": "task1163-a67ddeeb8c41466093ae597109050397", "input": "Here we develop a Markov Chain Monte Carlo ( MCMC ) method for estimating epidemiological parameters of the 2001 outbreak for a range of simple transmission models.", "output": [ "purpose" ] }, { "id": "task1163-5e5be729644d4b16afaf0e5577d81fd4", "input": "Here , we have characterized functionally and structurally the interaction between the DV fusion peptide and different model membranes by fluorescence and NMR.", "output": [ "method" ] }, { "id": "task1163-4f686891b5464b48b1dd235642bb8004", "input": "they have enhanced replication and virulence in mice.", "output": [ "finding" ] }, { "id": "task1163-8738fbb175544bbb8f971997ba10efbd", "input": "This study investigated the 3 7.3 kb genome of eight Taiwan strains isolated from 1992 to 2007.", "output": [ "purpose" ] }, { "id": "task1163-708a4be5076d4a8b9f6b0d0ccd3431c9", "input": "resulting in smarter drugs that reach their target still with the original bioavailability.", "output": [ "purpose" ] }, { "id": "task1163-d7d818345f5e47298479e558e1647046", "input": "5c , 5f , 5h and 5i is accompanied by low cytotoxicity.", "output": [ "finding" ] }, { "id": "task1163-6e4074798118429ab305a73b83d268be", "input": "Reovirus activates RIG-I and IPS-1 for phosphorylation of IRF3.", "output": [ "background" ] }, { "id": "task1163-f6edde921fe44b01b1950d2fb8fccd61", "input": "or single new virus detection episodes where HRV positive specimens could not be sequenced.", "output": [ "finding" ] }, { "id": "task1163-99dfa241963c4406997c67aa23be562c", "input": "These large-plaque variants emerged following viral replication in several different tissues.", "output": [ "finding" ] }, { "id": "task1163-6f29c61cbd4d42e49b62de2b20406fb2", "input": "Secondary outcomes included incidence of SARS-CoV-2related acute respiratory distress syndrome ( ARDS ) and the proportion of patients requiring mechanical ventilation.", "output": [ "method" ] }, { "id": "task1163-08e542085cc343a8a32f60ebe74ecdcf", "input": "the etiological agent of the 2003 worldwide epidemic that culminated in approximately 8,000 cases and 800 deaths.", "output": [ "purpose" ] }, { "id": "task1163-45ec02cd2d80426f9cebcebe0898f957", "input": "The genes of interest were directly sequenced.", "output": [ "method" ] }, { "id": "task1163-a40ca29fb16d43a496993c3c964ccc81", "input": "Healthcareacquired MERS infection has become a well-known characteristic of the disease and a leading means of spread.", "output": [ "background" ] }, { "id": "task1163-7f0aab2ee5864f39b846b1aab68976f6", "input": "Second , routine HIV testing is being implemented in populations at high risk of infection.", "output": [ "method" ] }, { "id": "task1163-98728bb867d84679b4ce99d8a181e0c8", "input": "may cause a significant amount of pediatric respiratory disease.", "output": [ "finding" ] }, { "id": "task1163-d05ec77c76da4233b45c968b9fa1c7ca", "input": "We describe herein the structure-guided design and evaluation of a novel class of inhibitors of MERS-CoV 3CL protease that embody a piperidine moiety as a design element that is well-suited to exploiting favorable subsite binding interactions to attain optimal pharmacological activity and PK properties.", "output": [ "purpose" ] }, { "id": "task1163-cd75ed7ae2cb41948b257c9ec6aeed5f", "input": "research on alternative therapies for calf diarrhea is necessary.", "output": [ "background" ] }, { "id": "task1163-bd443e6cecf2440d81aa56d78a29e14f", "input": "the investigation of natural selection is leading to new insights into the function and dysfunction of human biology.", "output": [ "background" ] }, { "id": "task1163-cbdc2445f86342859a66d2b18c30cdf3", "input": "and explore novel ideas of representing active genomes which promise being particularly adapted to dealing with the modeling challenges posed by host-pathogen interactions.", "output": [ "purpose" ] }, { "id": "task1163-7e5d9490fd9e4bacac463fec2e363b64", "input": "based on a random sample of the Dutch population.", "output": [ "method" ] }, { "id": "task1163-04fcbc3334e4405f8034fe0887b083be", "input": "The comparison of secondary structures revealed no new structural domains in the genotypic variants.", "output": [ "finding" ] }, { "id": "task1163-fa3c9ac269ec45529e5c9b7a7fcfd115", "input": "To assess the viability of isolation and contact tracing to control onwards transmission from imported cases of 2019-nCoV.", "output": [ "purpose" ] }, { "id": "task1163-8d5b901b62b24a85bf58e8bab3f07e63", "input": "HR121 or 5-Helix protein could serve as specific antiviral agents.", "output": [ "finding" ] }, { "id": "task1163-95df961aa0fa48e099fbe36d6c943b17", "input": "S h ; infected , I h ; recovered , R h.", "output": [ "method" ] }, { "id": "task1163-6cd14b05b8fa4d5ca4a4328a5432531c", "input": "The objective of this study was to test the relevance of such a model for the discovery and validation of antiviral drugs.", "output": [ "purpose" ] }, { "id": "task1163-78570ab9245244d09b684f0749b96ba5", "input": "the infection of non-avian species has been investigated.", "output": [ "background" ] }, { "id": "task1163-cc3f44ff5d18495c86000006b1927552", "input": "The feasibility study investigates the reliability of the state of the art heart rate measuring methods in realistic situations.", "output": [ "purpose" ] }, { "id": "task1163-762902a62da0470396f0c6f9ec4163fe", "input": "This review attempts to identify potentially important genes that show some consistency in ( relative ) up or downregulation in key tissues between the resistant and susceptible chickens.", "output": [ "purpose" ] }, { "id": "task1163-e6663b1eed064cd08cf5d99a27966ee6", "input": "and a significant number of reports on nosocomial and occupational outbreaks have been reported.", "output": [ "background" ] }, { "id": "task1163-a5fadce14f1541408bced9f84f4b3dea", "input": "resistance profile and pharmacological properties over enfuvirtide.", "output": [ "finding" ] }, { "id": "task1163-dc87b89d9ee6477da2a4b01834f6956e", "input": "The high mutation rate of the human immunodeficiency virus type 1 ( HIV-1 ) virus is a major problem since it evades the function of antibodies and chemical inhibitors.", "output": [ "background" ] }, { "id": "task1163-b01232ffe8924a04b767d85d06efbf5f", "input": "non-incineration technologies will develop quickly and will soon become the main technical option.", "output": [ "background" ] }, { "id": "task1163-057531e586f1434e8f8eb50e446da854", "input": "and platelet-derived growth factor ( PDGF ) - BB were measured on admission.", "output": [ "method" ] }, { "id": "task1163-205440659c004984a8606f33ecab0a5e", "input": "have been identified as one of the major factors expected to constrain hospitals ' ability to deal with future outbreaks of emerging infections.", "output": [ "background" ] }, { "id": "task1163-c75b419d73614e1fb18e40aa7e60d5c4", "input": "Objectives : The purpose of this paper is to propose a PPE calculation system to help hospitals to decide their PPE stockpile.", "output": [ "purpose" ] }, { "id": "task1163-a246d86df2aa42dcad8155411d25b890", "input": "This randomized field trial was conducted on 5 commercial dairy farms in Ohio.", "output": [ "method" ] }, { "id": "task1163-f4421b9871f544bfa29f837d374c7b8d", "input": "Severity was evaluated on the basis of a combined assessment of the severity of infection and severity of the clinical condition of the patients.", "output": [ "method" ] }, { "id": "task1163-7167df42df764a95a5e9b502c55adf15", "input": "or disease outbreaks , in which data required for research response are only available after the start of an outbreak.", "output": [ "background" ] }, { "id": "task1163-adf4b45e627b4941ba44336999eb0ff5", "input": "a model coronavirus in the same genus as SARS-CoV and MERS-CoV.", "output": [ "method" ] }, { "id": "task1163-d875889ecbc543c08ae33b61630562db", "input": "Chinese giant salamander thymus cells ( GSTC ) and Epithelioma papulosum cyprinid ( EPC ) cells.", "output": [ "method" ] }, { "id": "task1163-9ac71b58776348f58efcfd27197fe39d", "input": "Here , we summarize the post-millennium ( 2000-2017 ) research on bats in China and point out trends and future directions based on neglected topics , groups , and regions.", "output": [ "purpose" ] }, { "id": "task1163-25ece59515be4d8e8a141fbfa4013e56", "input": "Singapore , and Hong Kong.", "output": [ "method" ] }, { "id": "task1163-ef63bf88235a43f58642fadcb9f11c18", "input": "There was no significant association with the other comorbidities.", "output": [ "finding" ] }, { "id": "task1163-54bcb0142b9b449e8220e00140a2fc0b", "input": "which can lead to cell death.", "output": [ "background" ] }, { "id": "task1163-9df18e8b035046b5b9880ed6f2372be6", "input": "which might be an operative alleyway to thwart dysentery from the world.", "output": [ "finding" ] }, { "id": "task1163-94e9c4da228a4dec8db7380f82124cd9", "input": "Here we review how SARS-Cov2 affects the eye and discuss implications for ophthalmologists.", "output": [ "purpose" ] }, { "id": "task1163-507e765b31744d38a850a39c0292ef15", "input": "The recent development of measles vaccine-based vectored vaccine candidates has been reviewed and some information on recombinant measles vaccines expressing respiratory syncytial virus proteins has been shown and discussed.", "output": [ "purpose" ] }, { "id": "task1163-649d7076c8a14140a68498f0a590faa9", "input": "The electrical conductivity of DNAs were measured using scanning tunneling spectroscopy ( STS ) at the molecular scale and cyclic voltammetry ( CV ) technique based on the reduction of Ag + ion.", "output": [ "finding" ] }, { "id": "task1163-e5ad7a29c4f0420fb82645f00219bfef", "input": "lung transplantation and thought to represent chronic rejection.", "output": [ "background" ] }, { "id": "task1163-1d781c04627f4eb8bb7820a8c7c663a2", "input": "Here we propose and validate a new methodology for the partition of large-scale phylogenies and the inference of transmission clusters.", "output": [ "purpose" ] }, { "id": "task1163-9b3f3c47d8c249cfa5d9940914923655", "input": "However , it remains unknown how the dimer structure maintains an active monomer conformation.", "output": [ "background" ] }, { "id": "task1163-e24fb19eea7247b58a6bd81b52044d7c", "input": "with a particular emphasis on pulmonary injury and disease.", "output": [ "background" ] }, { "id": "task1163-8a9122ca1d304e00a03081d4e4209b44", "input": "147 human homologues , possible functional genes and 36 pseudo/unidentified genes ) by GENSCAN and BLASTN , BLASTP RepeatMasker programs.", "output": [ "background" ] }, { "id": "task1163-dd1c9693c0344e4c8c7226eb676754f8", "input": "and form the substance of a new WHO IPC guideline.", "output": [ "finding" ] }, { "id": "task1163-03c2d7e9c9a740f298c4af95884bfadb", "input": "There is even less understanding of the relative robustness of these methods with respect to partial information.", "output": [ "background" ] }, { "id": "task1163-73617a749cd04fc08a357bea9c5beaae", "input": "However , the accuracy of procalcitonin to discriminate between viral and bacterial pneumonia requires further dissection.", "output": [ "background" ] }, { "id": "task1163-22552e0279204f06a9aedb87ead13f82", "input": "other than those found in the literature.", "output": [ "method" ] }, { "id": "task1163-c7926260d1e04ae894be577584961562", "input": "By this model definition , we are able to detect the beginning of each bubble period even before it bursts.", "output": [ "background" ] }, { "id": "task1163-c2b39b5ae892422a9ceb954ecf5b3b2b", "input": "3C-like protease ( 3CL pro ) plays pivotal roles in the life cycle of severe acute respiratory syndrome coronavirus ( SARS-CoV ) and only the dimeric protease is proposed as the functional form.", "output": [ "background" ] }, { "id": "task1163-1d19d8aa5a864145b8375d84015b16c9", "input": "A standardized score was used to quantify symptom severity.", "output": [ "method" ] }, { "id": "task1163-d98a0401072b492698acaae9cad3c815", "input": "and ( 5 ) that involve pathogens that can be easily spread to wildlife populations.", "output": [ "finding" ] }, { "id": "task1163-3b799272632c4c69b26fafe97de9f864", "input": "while too weak immune responses might cause viral persistence.", "output": [ "background" ] }, { "id": "task1163-fbd42f0ff38d4f7eb75a9fe7bc34ef1a", "input": "phylogenesis and pathogenicity of the PHEV/2008 strain.", "output": [ "purpose" ] }, { "id": "task1163-20ec4ccb618244afb51ef0b10e039eb3", "input": "Visiting time The complex patterns of individuals arriving at and leaving a location are not considered.", "output": [ "method" ] }, { "id": "task1163-05022054ca3141a08c5f01657ac90429", "input": "By pulse-chase labeling experiments in the presence of drugs which inhibit Nlinked oligosaccharide addition and processing we demonstrate that addition of high mannose precursor oligosaccharides is necessary for transport and cleavage of the viral GP-C glycoprotein.", "output": [ "background" ] }, { "id": "task1163-a7046c504e2f430dac6fb6f2b3a27a51", "input": "and on Day 10 , when sinusitis was diagnosed.", "output": [ "method" ] }, { "id": "task1163-b7fd30b65c714da98eb2fcf0f9f37d77", "input": "Viral propagation was strictly limited to the neurons and to an established line ofneuroblastoma cells in in-vivo and in-vitro experiments.", "output": [ "method" ] }, { "id": "task1163-8a766b78e5d24e6c891e4ab687fdbadb", "input": "and healthcareacquired infections among patients and from patients to healthcare workers.", "output": [ "background" ] }, { "id": "task1163-4f747a48b618415583974c1b28c4d37c", "input": "This study investigates property securities bubbles and crashes by using a dynamic mathematical methodology developed from the previous research ( Watanabe et al. 2007a , b ( 31,32 ) ).", "output": [ "purpose" ] }, { "id": "task1163-ee4787bfa113437ea91c8a5511e3915c", "input": "This article expands on recent findings about bats and viruses and their relevance to human infections.", "output": [ "purpose" ] }, { "id": "task1163-f63e3b19a1b1451f89ce855bec4b242d", "input": "a betacoronavirus in the same genus as the medically important SARS-CoV and MERS-CoV.", "output": [ "method" ] }, { "id": "task1163-0f0821611b7a495c9fff76a0ae54f54a", "input": "Here we use the available evidence to evaluate the effectiveness of exit and entry screening for detecting travellers with 2019-nCoV.", "output": [ "finding" ] }, { "id": "task1163-69997be861c04c04b0ec109cc6ea2f22", "input": "leading to the design and implementation of surveillance systems.", "output": [ "background" ] }, { "id": "task1163-2c81f492108c4185824ed6594f1cb0e8", "input": "This article discusses several conditions that are distinct entities but share the common thread of abnormal lung parenchyma that regularly leads to patient referral for surgical consideration.", "output": [ "purpose" ] }, { "id": "task1163-da09352ba839478d8b6fc0d9c8fce37c", "input": "China , Indonesia , Taiwan and the Philippines.", "output": [ "background" ] }, { "id": "task1163-8452da11abd745adba88aee65c135b90", "input": "To this end we make recommendations about the information that should accompany faecal and other samples submitted to the laboratory from outbreaks of gastroenteritis.", "output": [ "finding" ] }, { "id": "task1163-26a97a92523d489297ab12b5c95e7122", "input": "Conclusion : On-site vaccination arrangements improved influenza vaccination rate among hospital employees.", "output": [ "finding" ] }, { "id": "task1163-3982447331e14ad683cb8ae0a2616385", "input": "This paper assesses the impact of the September 11 terrorist attacks and its after-effects on U.S. airline demand.", "output": [ "purpose" ] }, { "id": "task1163-57f7886a1fee4cb8a91a9604b418f97f", "input": "Such analysis using GFP that precedes stable plant transformation will enable the rapid screening of multiple constructs to attain optimal recombinant protein expression.", "output": [ "method" ] }, { "id": "task1163-ec2f4202e1204e4c9c4da8ecce2d16fd", "input": "which frequently do not respond to broad-spectrum antibacterial therapy.", "output": [ "finding" ] }, { "id": "task1163-9acc785306dd40beafae2326cd62ab0f", "input": "both of which reduced viral replication.", "output": [ "finding" ] }, { "id": "task1163-72ecdf01a9574cb69dd98daff5c2d4a8", "input": "In addition , treatment of EV71-infected iDCs with SP600125 and SB203580 could inhibit secretions of IL-6 , IL-10 and TNF-α.", "output": [ "finding" ] }, { "id": "task1163-52a0d0f6341743509f2690192a10a03b", "input": "the parameters used for DCL generation will affect the equilibrium composition and amplification factors.", "output": [ "finding" ] }, { "id": "task1163-957ff9b89f944f2595c51da9b64470b7", "input": "including cancers , particularly in immune-suppressed hosts.", "output": [ "background" ] }, { "id": "task1163-c49a6eaaf6f24562a4b1320d5ff2ba59", "input": "There was a significant weight loss in KO mice at Day 2 and significantly higher disease scores during the 7 days of observation.", "output": [ "method" ] }, { "id": "task1163-63d162bad54a4148b3c5241e55079394", "input": "especially those in plasma/serum specimens.", "output": [ "purpose" ] }, { "id": "task1163-007fbb92f02c4b3d8af3c76c34097a63", "input": "This review focuses on pathophysiology of stable and exacerbated COPD.", "output": [ "purpose" ] }, { "id": "task1163-94a14ca4a2e44fd5b7e88d3dcd629aa2", "input": "2012 , in Jeddah , Saudi Arabia.", "output": [ "background" ] }, { "id": "task1163-c09d4bdda085464eadba6789a04921af", "input": "-5 , and -8 genes and IFN signaling as the most significantly impacted pathways.", "output": [ "finding" ] }, { "id": "task1163-2c4e09e64a884d69a43563a5ffe860c9", "input": "Recently several of the lead-like compounds proposed by us were reported as being active in the literature.", "output": [ "finding" ] }, { "id": "task1163-8481684888c248cf849b2c1978b4b67f", "input": "and PPV of 2.8 %.", "output": [ "finding" ] }, { "id": "task1163-e2c3582a34fe45b6b322399ae3402147", "input": "a human herpesvirus , specifically interacts with Nmi.", "output": [ "purpose" ] }, { "id": "task1163-d18d863d3d5148c1ab1e476117907ab9", "input": "Results : The results revealed that K-601 reduced the level of inflammations in both antiinflammatory models in a dose-dependent manner.", "output": [ "finding" ] }, { "id": "task1163-187c8a26b4bc4720a4a120b2bb1f7c49", "input": "Fecal samples were collected from both donor and recipient prior to each FMT and from recipients 24 hours following the last FMT.", "output": [ "method" ] }, { "id": "task1163-64d4f48554bd43e4b5fe23b664fa3720", "input": "Live attenuated recombinant measles vaccine virus ( MV ) Edmonston-Zagreb ( EZ ) strain was evaluated as a viral vector to express the ectodomains of fusion protein of respiratory syncytial virus ( RSV F ) or glycoprotein 350 of Epstein-Barr virus ( EBV gp350 ) as candidate vaccines for prophylaxis of RSV and EBV.", "output": [ "method" ] }, { "id": "task1163-ea56ce73b8fb44bd8ed77bee3956b4ac", "input": "additional subjects were immunized with a single dose of 15 g VLP vaccine ( N = 2537 ) or placebo ( N = 1011 ) and assessed for safety in Part B. Results showed the H1N1 2009 VLP vaccine was safe and well-tolerated.", "output": [ "method" ] }, { "id": "task1163-3ffa50bd59a644fcb3d3a4989c378779", "input": "It was revealed that both the N-and C-termini of the SARS-CoV E protein are exposed to the cytoplasmic side of the membranes ( N cyto C cyto ).", "output": [ "finding" ] }, { "id": "task1163-63c3bf64e3b84efeb0f036a7abcf361f", "input": "These data demonstrate the intracellular protective role of this bacterial surface polysaccharide against autophagy.", "output": [ "finding" ] }, { "id": "task1163-07281467b8194101a0b61065c0da7049", "input": "along with 586 time course readings from aircraft.", "output": [ "method" ] }, { "id": "task1163-677d0b4a830848ecb9a667bd5a6ef9a1", "input": "The Cyprinus herpesvirus 3 ( CyHV-3 ) is a member of the new Alloherpesviridae virus family in the Herpesvirales order.", "output": [ "background" ] }, { "id": "task1163-9757d72030d94a70ac7b80c98bdabe67", "input": "Chickens were challenged with Eimeria maxima oocysts and 7 days post-challenge body weight gains and gross and microscopic lesions were recorded to evaluate protection levels for the different vaccine applications.", "output": [ "finding" ] }, { "id": "task1163-b0b155094f27431ea3e9bd260a7cfa60", "input": "Transgene integration and expression of the PEDV spike protein 1 gene were confirmed by genomic PCR and RT-PCR and western blot analysis of transgenic Lemna , respectively.", "output": [ "method" ] }, { "id": "task1163-896f98a8f86046ab97f52a0989ffc3f0", "input": "Knowledge of the survival characteristics of the virus is essential for formulating appropriate infectioncontrol measures.", "output": [ "background" ] }, { "id": "task1163-4b4a76665e314af3932c0534a8d44332", "input": "None of the children in this study were known to have any immunosuppressive conditions.", "output": [ "method" ] }, { "id": "task1163-8b13a15bf0df4323b6afa11283100d16", "input": "mortality and health care costs associated with asthma.", "output": [ "background" ] }, { "id": "task1163-7bb74dba3e5e4f2b90c837c8dad4e7a0", "input": "Sixteen of these 27 specimens ( 59 % ) contained picornaviruses ; of these 9 ( 57 % ) contained RNA of a recently discovered clade of rhinoviruses.", "output": [ "finding" ] }, { "id": "task1163-526e51fa0ecd4fd288d59be7a34d75cf", "input": "The power of molecular biology and bioinformatics has enabled the complete decoding of the viral genome within weeks.", "output": [ "background" ] }, { "id": "task1163-32667b1b43a94d9390c2ed8d69cbe87d", "input": "providing timely treatment , and differentiating the infected cases from the healthy , thus preventing further epidemics.", "output": [ "background" ] }, { "id": "task1163-973a4b7f65dc461b824b956f8f9a1ce3", "input": "and we investigated the psychological effects on hospital nurses associated with their experiences during the disaster.", "output": [ "purpose" ] }, { "id": "task1163-d947d06c54314b798029124493876631", "input": "complete data were analyzed for 3154 to assess factors that are independently associated with MERS-CoV infection.", "output": [ "finding" ] }, { "id": "task1163-d964e9a88b0943f6a23ae33f7ec8446d", "input": "In coronaviruses , the receptor binding domain ( RBD ) in the distal part of S1 subunit of SARS-CoV-2 spike protein can directly bind to angiotensin converting enzyme 2 ( ACE2 ).", "output": [ "background" ] }, { "id": "task1163-43b672cb248c43cc9b9a1738f96e6351", "input": "At the same time a survey of the methods generally used for the evaluation of antioxidant activity and some of the mechanisms involved in the anti-inflammatory activities of essential oils are also reported.", "output": [ "purpose" ] }, { "id": "task1163-48d26b41f95446b9b0c6a7bef4b0acba", "input": "This will provide valuable information to researchers who are deciding whether to use hamsters as an animal model.", "output": [ "purpose" ] }, { "id": "task1163-38c0b5bdc0b94f0593b1ff2233b4260f", "input": "focusing on specific applications and limitations of each vaccine category.", "output": [ "purpose" ] }, { "id": "task1163-560eec398d2f47f1b148a13579619259", "input": "an acute phase protein , was associated with worse outcome in lung transplant patients.", "output": [ "background" ] }, { "id": "task1163-07a5f50445924bc4b70e4102e4c71b84", "input": "and focal aggregates of adherent necrotic cells were present.", "output": [ "finding" ] }, { "id": "task1163-6520fc721aaf49b3bca94949a56b8de4", "input": "Here , the immunogenicity of a novel antigenic domain found on the carboxy-terminal of the spike protein characterized by the peptide motif GPRLQPY , was evaluated.", "output": [ "method" ] }, { "id": "task1163-2c8e1c0d25b345938b760074843c3d0b", "input": "Gm15441 LSL mice were treated with a PPARA agonist or fasted to assess how loss of Gm15441 impacts hepatic inflammasome activation in response to both pharmacological and physiologically-induced metabolic stress.", "output": [ "finding" ] }, { "id": "task1163-63ff904ad99e4dd3953dc474859f0129", "input": "Previously obtained sequence data of the spike gene of IBV QX-like and Massachusetts strains were subjected to bioinformatics analysis.", "output": [ "background" ] }, { "id": "task1163-68146837621349a6b3abcb54806e1fe5", "input": "but with a timevarying , largely damping , transmission rate.", "output": [ "purpose" ] }, { "id": "task1163-80bb584db3ed424e81585a1229070243", "input": "protect against , control - and provide a public health response to - international spread of disease.", "output": [ "purpose" ] }, { "id": "task1163-1c2c4e4c03934d9c972a3dd39997674e", "input": "Aim of the study : To investigate the effect and mechanism of BHT in the prevention of lipopolysaccharide ( LPS ) fever in manners of immune modulation.", "output": [ "purpose" ] }, { "id": "task1163-ce28537d97fd4464bf33698d384ca0cb", "input": "This study compared standard care with care delivered using a mobility protocol.", "output": [ "purpose" ] }, { "id": "task1163-195608f3b96840df91864e6cec549492", "input": "particularly their correlation with the information environment.", "output": [ "purpose" ] }, { "id": "task1163-f8b9744fd31746cd9ba4f4124133fb40", "input": "Discuss the definitions of terrorism and weapons of mass destruction and their relation to the illicit use of biological agents.", "output": [ "purpose" ] }, { "id": "task1163-20c5cf9ae4fb44cfbaf653a0543e8d2b", "input": "to monitor the activity of HAV 3C pro in human embryonic kidney cells ( HEK-293T ).", "output": [ "method" ] }, { "id": "task1163-c8b4b38547a24af4ac9027025c405fd5", "input": "and two reviewers independently reviewed full texts.", "output": [ "method" ] }, { "id": "task1163-22c157cfeb5e45e6872428057690a9b8", "input": "the primary objective was to estimate the effectiveness of influenza vaccines using a cohort design for comparison with studies using the testnegative design ( TND ).", "output": [ "purpose" ] }, { "id": "task1163-bbd2f6c27e1846e191c5405a132b8cd1", "input": "An alternate model is discussed.", "output": [ "finding" ] }, { "id": "task1163-4b640a313aec48718420a103685a6c7a", "input": "In this chapter , we present an overview of statistical mechanical models for RNA folding and then focus on a recently developed RNA statistical mechanical model -- the Vfold model.", "output": [ "purpose" ] }, { "id": "task1163-81481a11b16c4c4e84d495dd3f5fd523", "input": "In the study group , a BPA alerted providers of the diagnostic results suggesting viral infection and prompted them to reassess the need for antibiotics.", "output": [ "method" ] }, { "id": "task1163-2e3d2f5f66b24e0fbf242863612f19c1", "input": "We further summarized reported viromes of common farm animals in order to translate these efforts as background virus diversity profiles of common farm animals to guide preparedness of diseases at the livestock-human interface.", "output": [ "finding" ] }, { "id": "task1163-ea36e020644e4496b6a9ef914020463b", "input": "The median lung `` total severity score '' of chest CT was 6.", "output": [ "finding" ] }, { "id": "task1163-2a33f976c3294fdbbdd27b03cafd5148", "input": "A specific BCoV-RT-PCR assay was used to detect BCoV in fecal samples.", "output": [ "method" ] }, { "id": "task1163-14c45aa3299d4eb18aad8568869d16e5", "input": "The spike protein of Porcine epidemic diarrhea virus is the main surface glycoprotein involved in virus attachment and entry and therefore is the target of neutralizing antibodies.", "output": [ "background" ] }, { "id": "task1163-6b32198147fc479b8ec8a2d03d1167ea", "input": "We examine rotavirus infection in the Maradi area in southern Niger using hospital surveillance data provided by Epicentre collected over two years.", "output": [ "purpose" ] }, { "id": "task1163-9ab5b6b3e6c34415bb720cace240f160", "input": "The `` failure of passive transfer '' ( FPT ) group had significantly lower IgG1 Abs to BCoV than the `` acceptable passive transfer '' ( APT ) group of calves ( log10 1.98 vs. 3.38 respectively ) ( p < 0.0001 ).", "output": [ "finding" ] }, { "id": "task1163-acc9caea25d24b75a3716cad65d96574", "input": "Methods employed for Q-PCR assay validation as required in ICH Topic Q2A Ž.", "output": [ "method" ] }, { "id": "task1163-6b4d6c731ff843d38696ce4841f75387", "input": "Aged rats underwent a unilateral distal permanent middle cerebral artery occlusion and one week later were treated with an anti-Nogo-A or control antibody.", "output": [ "method" ] }, { "id": "task1163-044310985ff441a387501b15ebc90cbf", "input": "Tokyo , Japan ) or the same milk replacer with no prebiotic ( control ).", "output": [ "method" ] }, { "id": "task1163-8622bc1295a44b57ae742f45092e4f44", "input": "and adopts the stochastic differential game theory to discuss this issue.", "output": [ "purpose" ] }, { "id": "task1163-9c5e040a4d4b4fa48013aaae44ff0c44", "input": "NCP severity , and underlying comorbidities were the risk factors for cardiac abnormalities in COVID-19 patients.", "output": [ "finding" ] }, { "id": "task1163-6cf08de3680444448df9644e1480662a", "input": "Carefully calibrated transmission models have the potential to guide public health officials on the nature and scale of the interventions required to control epidemics.", "output": [ "background" ] }, { "id": "task1163-1d48b4167c554f28b6db02f993611463", "input": "non-Hispanic and 39 % were Hispanic.", "output": [ "finding" ] }, { "id": "task1163-b6cb63dc3e8e471884a624205aa9d62b", "input": "Efforts are underway to establish domestic and international handling guidelines and to recommend suitable quarantine conditions to facilitate embryo importation.", "output": [ "purpose" ] }, { "id": "task1163-701440dfd30e4c3c94fdb18430ed4d8f", "input": "The Shortest Common Supersequence Problem asks to obtain a shortest string that is a supersequence of every member of a given set of strings.", "output": [ "background" ] }, { "id": "task1163-f95a321dd76d4da7918e52c65600dd9f", "input": "The interferon-induced transmembrane protein 3 ( IFITM3 ) is a widely expressed potent antiviral effector of the host innate immune system.", "output": [ "background" ] }, { "id": "task1163-02f3a681ff5d40be8626006a9ae5b596", "input": "SpyTag ( A ) , and SpyCatcher ( B ).", "output": [ "background" ] }, { "id": "task1163-5107fa9e650340a6a89368e920602ec3", "input": "while QX-like isolates did not have the Ser534 site.", "output": [ "finding" ] }, { "id": "task1163-6820cf6b238742148b26ca0cdf48e819", "input": "four-arm elastin-like star proteins demonstrate remarkable tolerance against trypsin digestion.", "output": [ "finding" ] }, { "id": "task1163-2f493b97531440b6af895f365815e3d6", "input": "We suggest a mode which is droplet combining with aerosol mode.", "output": [ "finding" ] }, { "id": "task1163-832407c439ba45eaa40e4bb5286fad97", "input": "measles and chickenpox , the concept of aerosol transmission is so well accepted that isolation of such patients is the norm.", "output": [ "background" ] }, { "id": "task1163-fe6020d4645543c194a534a65e69e5f4", "input": "Following testing rats were sacrificed and brains processed for the Golgi-Cox method.", "output": [ "method" ] }, { "id": "task1163-92e669cb169e4297aa4a423a87193f39", "input": "Murine models are not clear on the role for B cells and antibodies in pathogenesis.", "output": [ "background" ] }, { "id": "task1163-118406ee89314399ba38c00fd7d68c5a", "input": "Episodes were defined `` asymptomatic '' if no symptoms of any respiratory tract illness were present between 1 week before and 1 week after sampling.", "output": [ "method" ] }, { "id": "task1163-202db503279f4569a34b3b5b783288d2", "input": "particularly those of human pathogens.", "output": [ "background" ] }, { "id": "task1163-c98b779eed77492b96aad2c3a39dd6c8", "input": "although the exact mode of transmission is unknown.", "output": [ "background" ] }, { "id": "task1163-5968109876ea4e53b21f71dc50135324", "input": "The objective of this study was to determine the role of XB130 in lipopolysaccharide ( LPS ) - induced septic responses and acute lung injury.", "output": [ "purpose" ] }, { "id": "task1163-4a890254fa584f2b92e22d5fdf92a4b1", "input": "In vivo this was associated with an increased number of alveolar macrophages and neutrophils in the lungs of IAV infected mice.", "output": [ "finding" ] }, { "id": "task1163-acc5606db4004dc78ec46783bab2ee1d", "input": "Consequently , it is of interest to better understand the role of T cells in vaccine-induced protection against NiV.", "output": [ "purpose" ] }, { "id": "task1163-d06cff0516fe4d38ab5f1a9f0d8789a5", "input": "We then address several AECB-specific issues that must be considered in cost-effectiveness analyses of AECB antimicrobial interventions.", "output": [ "purpose" ] }, { "id": "task1163-980dff7b0fc84009ad7205b01e246df1", "input": "suggesting that education about the health risks of radiation exposure is important for health-care professionals.", "output": [ "finding" ] }, { "id": "task1163-96ecf0f533d248398360dab23a39e235", "input": "Methods : Our study included 800 upper respiratory tract specimens of which 400 negative and 400 positive for viral detection in multiplex PCR.", "output": [ "method" ] }, { "id": "task1163-88046856462b4135abe25d7ccd34b147", "input": "This study intended to investigate the utilization of Chinese medicine ( CM ) for respiratory symptoms by patients with a medical history of TB in Taiwan.", "output": [ "purpose" ] }, { "id": "task1163-9bd6fc8112a84c44926d2f4b6afcb873", "input": "Furthermore , the in vivo study showed that pentoxifylline at a concentration of 100 mg/kg and 200 mg/kg body weight was able to protect completely mice challenged with 50 × 50 % lethal dose ( LD 50 ) of JEV.", "output": [ "finding" ] }, { "id": "task1163-93db1a66be81467e812b74e759a2cb99", "input": "we give an overview of advances in research on the coronavirus fusion peptide with an emphasis on its role and properties within the biological context of host cell entry.", "output": [ "purpose" ] }, { "id": "task1163-269b0e38c447496889278623fe4ff81f", "input": "Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining.", "output": [ "method" ] }, { "id": "task1163-b1db45185add44df9bfa2fcadcee9d1c", "input": "and serum were collected as appropriate for diagnoses.", "output": [ "method" ] }, { "id": "task1163-a603c8ddaef64d3faa9eb1c39c590e20", "input": "The objective of this paper is to quantify the development of the rural electricity market at county level and below in China.", "output": [ "purpose" ] }, { "id": "task1163-9014be10c869416f922383db90064619", "input": "In this paper , we specify a general stochastic SIR epidemic model and prove that the mean generation interval decreases when susceptible persons are at risk of infectious contact from multiple sources.", "output": [ "purpose" ] }, { "id": "task1163-e7ce7539c696491eaafbb5322eb46de8", "input": "HIVinfected patients may be predisposed to these viral infections due to immunodeficiency or to risk factors common to HIV and other viruses.", "output": [ "background" ] }, { "id": "task1163-9d49954aa33e439296afd3f894f153d9", "input": "we quantified the effects of all single mutations and double mutations between all positions in the IgG-binding domain of protein G ( GB1 ).", "output": [ "method" ] }, { "id": "task1163-296fd812c853429eb242868d5b941d20", "input": "it is critical to understand the mechanisms underlying immunocompetence in this reservoir host.", "output": [ "purpose" ] }, { "id": "task1163-e312b3e188c64a2eb4c8f171f526441c", "input": "Chemicals were from Roche , Sigma , or Merck.", "output": [ "method" ] }, { "id": "task1163-bf0db15f9d9a4bd398c750d188395018", "input": "In this article , the physiological and biochemical characteristics of the brown pigment in commercial brown-egg layers are reviewed in relation to its various functions in the poultry industry.", "output": [ "purpose" ] }, { "id": "task1163-220e5f105baa43519f34088a599f5893", "input": "nor attenuated its anti-HIV-1 activity.", "output": [ "finding" ] }, { "id": "task1163-49a65b21ca914a1cbc182dc2dd2b8558", "input": "Partial nucleotide sequences of the S1 spike gene was determined from the PEDV-positive samples and compared with S1 sequences from other countries.", "output": [ "method" ] }, { "id": "task1163-a17a9c83e9114cdaa1a1dd6a6a599ffc", "input": "comprising a 5 ′ terminal cap structure and a 3 ′ poly A tail.", "output": [ "finding" ] }, { "id": "task1163-16340c459cee491ba348861f808868f0", "input": "the RdRp resides in a replicase subunit that is unusually large.", "output": [ "background" ] }, { "id": "task1163-748307ec831249a98911aa120b4921ec", "input": "to prevent shifts in equilibria due to precipitation.", "output": [ "background" ] }, { "id": "task1163-bdd9466a69d64f71aea2bfb20d3e13fa", "input": "The full-length pDC-SIGN cDNA encodes a type II transmembrane protein of 240 amino acids.", "output": [ "method" ] }, { "id": "task1163-f229beec029748a08fbdfadd3145386e", "input": "implicating subtle differences between ferret and human IL-2 when initiating biological functions.", "output": [ "finding" ] }, { "id": "task1163-cd749d568e46471f982373e21d57fd5f", "input": "and a clear outline of the kinds of evidence that would give proof to controversial claims.", "output": [ "finding" ] }, { "id": "task1163-a86867edfefe46b785f45c42e18a8f7c", "input": "A daily tick-box diary captured predefined respiratory symptoms from birth until their second birthday.", "output": [ "method" ] }, { "id": "task1163-5b585e4a29af413a958730347309934d", "input": "particularly the coal combustion fly particles which may be possible virus carrier.", "output": [ "finding" ] }, { "id": "task1163-a0f3a38d292f494797aa69fe48d6f8cf", "input": "A national control program against bovine respiratory syncytial virus ( BRSV ) and bovine coronavirus ( BCV ) was launched in Norway in 2016.", "output": [ "background" ] }, { "id": "task1163-5f8b09e1c6774961adac03807c6a128f", "input": "Admissionrelated electronic medical records were reviewed in entirety.", "output": [ "method" ] }, { "id": "task1163-fde9c4c6fc114af4af6aafc9901ba8ca", "input": "Primary structure data showed difference in the physical properties and hydrophobic nature of both genotypes.", "output": [ "finding" ] }, { "id": "task1163-9e6c8b46a5754f97a0b26efbbc460963", "input": "for patients with severe pneumonia.", "output": [ "finding" ] }, { "id": "task1163-09a6b9d955cd4f6d901887a1c1f457e1", "input": "a SARS-CoV was engineered including two tags associated to the E protein.", "output": [ "background" ] }, { "id": "task1163-b70af610e2a44d3fb05d1db34655233b", "input": "were identified using semi-nested polymerase chain reaction ( PCR ) assays and one-step PCR assays , respectively.", "output": [ "method" ] }, { "id": "task1163-ed825494dcb24c8d9aba8316cf9ea670", "input": "52 °C for 15 seconds and 72 °C for 30 seconds and terminal elongation at 72 °C for 5 min.", "output": [ "method" ] }, { "id": "task1163-0a4adb62638341e895e91c35e728cf7e", "input": "with a random distribution ( 68 % ).", "output": [ "finding" ] }, { "id": "task1163-0f6090e497ab43ee8809a1394bedd382", "input": "which was inspired by such viruses.", "output": [ "purpose" ] }, { "id": "task1163-2ba9897091564d208a5aaff388bca810", "input": "1,2 Most of these reversible reactions take place in water , which makes them biocompatible.", "output": [ "background" ] }, { "id": "task1163-8389297d6a3848208dc6fe6a0bfed6e8", "input": "Neuropathological examination showed a marked inflammatory reaction in the cerebral leptomeninges and the grey matter of the brain.", "output": [ "background" ] }, { "id": "task1163-ca89da98e1d648d3af35deca5de966e1", "input": "have also been investigated , in an attempt to clarify the essential molecular features of the interactions involving the tryptophan residues.", "output": [ "method" ] }, { "id": "task1163-0515cc915c9b48598d11117f55ee2152", "input": "We have shown that Tat activates GFAP expression in astrocytes ( Zhou , et al. , Mol.", "output": [ "background" ] }, { "id": "task1163-6c610613a35041659dd5e7edab336119", "input": "Here , we predict whether a virus can infect humans directly from next-generation sequencing reads.", "output": [ "purpose" ] }, { "id": "task1163-ee8e380b442a49178f07cb7725d66ef5", "input": "Infection control measures may have prevented nosocomial transmission of the virus.", "output": [ "finding" ] }, { "id": "task1163-0e8814e25ebb49109d71ef8f8a8ba823", "input": "were identified by checking the hospitals ' administrative databases.", "output": [ "method" ] }, { "id": "task1163-74cf61cbe88f4e929714752ae8c26703", "input": "ATA binds to the essential Cys403 and Arg409 residues in the active site and has a stronger binding affinity than the natural substrate ( pTyr ).", "output": [ "finding" ] }, { "id": "task1163-cca0d86b4a914411b31c22598e6d98ca", "input": "To date , 114 human cases of MERS-CoV have been reported , with 54 fatalities.", "output": [ "background" ] }, { "id": "task1163-07d3892a0494493d8c1accd41ee4884e", "input": "Further domain swapping experiments uncovered additional speckle-inducing and - suppressive elements in nsp15s of SARS-CoV and TGEV.", "output": [ "finding" ] }, { "id": "task1163-e39bc39482554a1f8fba67573b85e7d5", "input": "which motivates research into broadly-acting antivirals that can provide a greater genetic barrier to resistance.", "output": [ "background" ] }, { "id": "task1163-c70904bbac804f419b1dcbe92b4e4d11", "input": "we have expressed a recombinant S1 protein of the SARS-CoV in transformed tobacco.", "output": [ "purpose" ] }, { "id": "task1163-3133a30cef8c4ce093a48bbaf454f7d8", "input": "cellular growth , and blood pressure control.", "output": [ "background" ] }, { "id": "task1163-88f9310be12b4cf0a5ecb6d90d24a509", "input": "New data on bat ectoparasites from Mindoro Island , Philippines are reported.", "output": [ "purpose" ] }, { "id": "task1163-d04844c629db4ef78b07fd78d2cbbb20", "input": "We also found possible index cases among children < 5 years old in the same household for 29.0 % ( 18 of 62 ) of young infants with RSV-ARI.", "output": [ "finding" ] }, { "id": "task1163-de001e562d4c434b8fc0da0ef25d339f", "input": "Most peptide inhibitors that target specific amyloidogenic proteins rely heavily on sequence recognition to ensure that the inhibitory peptide is able to bind its target.", "output": [ "background" ] }, { "id": "task1163-59df6399e8024aa7be9e096f4107e717", "input": "The joining of the non-contiguous leader ' and ` body ' sequences presumably occurs during minus-strand synthesis.", "output": [ "method" ] }, { "id": "task1163-b4df948111e944ad81619e68c1bd9f7b", "input": "The purpose of this paper is to examine the relationships between the emergent concept of fear of expatriation with further workplace fears ( economic crisis and dangerous working conditions ) and with mental health problems.", "output": [ "purpose" ] }, { "id": "task1163-438180b2dd5e432d95f6ac1f933b6c13", "input": "reproductive , and glandular tissues of 12/12 ( 100 % ) rats.", "output": [ "finding" ] }, { "id": "task1163-15971f5f94a04fc58082c5a242a10ebb", "input": "Within these systems , monoclonal aptamer microbeads can be individually generated and assayed to assess aptamer candidate fitness thereby helping eliminate stochastic effects which are common to classical SELEX techniques.", "output": [ "background" ] }, { "id": "task1163-92218dcb49dd4e5095e6707acf88d68e", "input": "western blot assay , and flow cytometry assay.", "output": [ "method" ] }, { "id": "task1163-26e1ad0f6a8a4cc1b51ef0cbccdc9b64", "input": "Calves were fed milk replacer containing 24 % crude protein and 18 % fat.", "output": [ "method" ] }, { "id": "task1163-b689a243677a46d69da0414c2793f0d7", "input": "Targeted recombination was used to introduce amino acid substitutions into the cleavage signal of the fusion glycoprotein ( spike or S protein ) of MHV strain A59.", "output": [ "method" ] }, { "id": "task1163-7168d6b141fc4e819615bcb58a9c2042", "input": "Finally , IELAGTLTL was shown to have the highest population coverage ( 83.86 % ) among the whole world population.", "output": [ "finding" ] }, { "id": "task1163-ca651386ff7e462c90c62b067d68942e", "input": "laboratory-confirmed COVID-19 was reported in 12 patients.", "output": [ "method" ] }, { "id": "task1163-dd0d4633a0ba44828348e5b053e0d263", "input": "and the epidemiological map is changing rapidly.", "output": [ "background" ] }, { "id": "task1163-e63a7646ed364abaa881730374c3f64c", "input": "and a low incidence in age groups above 12 months ( 3.45 % ).", "output": [ "finding" ] }, { "id": "task1163-1a5bc3e1302b46c4b6365e4d94ad9135", "input": "most likely by disrupting IRF9 function as part of the heterotrimeric transcription factor complex , ISGF3.", "output": [ "finding" ] }, { "id": "task1163-f7192a39821b48da826552b5fe1da8e4", "input": "the causative agent of Chagas ' disease.", "output": [ "background" ] }, { "id": "task1163-d1d7c705a8034e9ea810b531c7051774", "input": "Bronchiolitis was diagnosed , and the patient did not receive antibiotics.", "output": [ "finding" ] }, { "id": "task1163-a48b71a9f99543fe9adcbae541d2191b", "input": "We report the first case of transmission of Panton-Valentine leukocidin-producing Staphylococcus aureus to a physician during the resuscitation of an infant with fatal pneumonia.", "output": [ "background" ] }, { "id": "task1163-788379df92ab4b4abf52ebdb4070feee", "input": "was used for the generation of MVA-NiV-G candidate vaccines expressing different versions of recombinant NiV-G.", "output": [ "method" ] }, { "id": "task1163-b2f46a9aa26b4346a8ffc829e8354b9d", "input": "We investigated the inhibitory effect of phosphorodiamidiate morpholino oligomers ( PMOs ) targeted against norovirus sequences.", "output": [ "purpose" ] }, { "id": "task1163-a4c6cace3b0e48b3a2a1597b8bf89ed4", "input": "Every enrolled child had a nasopharyngeal aspirate ( NPA ) sample taken.", "output": [ "method" ] }, { "id": "task1163-485e46d2c6bd42fcb68f9b982aa237bd", "input": "The high binding site plasticity is a major challenge in computational drug discovery/design efforts.", "output": [ "background" ] }, { "id": "task1163-a7fb14e987864cb3afa5c6fecf38fa20", "input": "whereas overexpression of a dominant inactive form of CRTC1 inhibited HBV transcription.", "output": [ "finding" ] }, { "id": "task1163-75b1747395264ff69dc430755a05d5a1", "input": "We looked at several investigations into the mental health of nurses after a nuclear disaster and in other situations.", "output": [ "method" ] }, { "id": "task1163-7ff9c492e6ff479285d70146c19abd97", "input": "designated NC98 , isolated from the bursa of birds exhibiting poult enteritis and mortality syndrome was determined.", "output": [ "method" ] }, { "id": "task1163-2206b0dd3994408c87f139a9bbae281d", "input": "We proposed that the potent inhibitory properties of ATA are a result of its strong binding in the YopH active site and in situ generation of hydrogen peroxide near catalytic cysteine residue.", "output": [ "finding" ] }, { "id": "task1163-a9e1bbff0a7a4ea08f4c7335bf060221", "input": "employs multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in tissue cells.", "output": [ "background" ] }, { "id": "task1163-8f428fe17e3d4012986b29492164d423", "input": "The coil-3 10 - helix conformational transition of the Ser139-Leu141 loop serves as an enzyme activity switch.", "output": [ "finding" ] }, { "id": "task1163-4c84658bb1c54fb6a5420d07b66c7f20", "input": "C-reactive protein level , and chest radiograph were used as the parameters for the evaluation.", "output": [ "method" ] }, { "id": "task1163-65feeed8d0c344a98d0ca28bce8fff3c", "input": "and the IgG1 subclass antibody is predominant.", "output": [ "finding" ] }, { "id": "task1163-5457cf833d034de1a24deb0a764ee308", "input": "to five subtypes of influenza virus A neuraminidase ( FluV-A NA ) were investigated in the context of aqueous solution by using molecular docking and molecular dynamics studies.", "output": [ "method" ] }, { "id": "task1163-ac5ad9064096435cab5ea89f3b6aa774", "input": "sites of ER-mitochondria interface critical for innate immune signaling.", "output": [ "finding" ] }, { "id": "task1163-7a5be73c5367437b9aea198784cb9809", "input": "many health care systems will implement a triage system that would potentially deny critical care treatment to some seriously ill patients.", "output": [ "background" ] }, { "id": "task1163-72e973494a524f55bb69b73374312102", "input": "Here we report a pseudovirus neutralization assay for rapid screening of neutralizing mAbs targeting hemagglutinin ( HA ) of H5N1 and H1N1 IAV.", "output": [ "purpose" ] }, { "id": "task1163-e1e94544fb554155a390d461b03cbbd8", "input": "Phenotype-based methods One of the oldest but still very important methods in clinical bacteriology is the detection of human pathogens by direct microscopic examination of the specimen.", "output": [ "background" ] }, { "id": "task1163-c40d2aaff45f4ee19cdcf2dd7b94edba", "input": "2020 to February 28 , 2020 were collected and retrospectively analyzed.", "output": [ "method" ] }, { "id": "task1163-432ad007fd71493d962170a0d404df92", "input": "Identity ( ID ) badges and lanyards worn by pediatric health care workers ( HCWs ) have been shown to be potential vectors of nosocomial bacterial infections.", "output": [ "background" ] }, { "id": "task1163-4561d76173bd40b2a450bda19011dc19", "input": "There are two forms of this complex : TRAPP I and TRAPP II.", "output": [ "background" ] }, { "id": "task1163-1ba8cf05268b4f348d342a217cbea40b", "input": "on the basis of the binding motifs in their active sites.", "output": [ "finding" ] }, { "id": "task1163-8526bb91264a457ea45f0db8311fd179", "input": "We propose that medRNA is spliced in trans to de-novo-initiated transcripts of protein-coding genes.", "output": [ "purpose" ] }, { "id": "task1163-64c17eb8558a4c3cb75ef8401c413d4c", "input": "We propose that CD151 organizes viral entry platforms with different types of integrin clusters for different functionalities.", "output": [ "purpose" ] }, { "id": "task1163-b69d8d19067c42ecb767619b09d3606f", "input": "44 % of the 15,558 liver-expressed lncRNAs are considered novel ( Melia and Waxman , 2019 ).", "output": [ "finding" ] }, { "id": "task1163-093fd77d8d7e41eeae3f4e314d9e6edf", "input": "Campylobacter , Clostridiurn difficile , rotavirus , Norwalk virus and Cryptosporidium.", "output": [ "finding" ] }, { "id": "task1163-e9ab02288f494650aab3c38a03ea26a7", "input": "This investigation further compared the FFD-Markov-chain model with the CFD-Eulerian model and CFD-Lagrangian model in terms of accuracy and efficiency.", "output": [ "method" ] }, { "id": "task1163-488010fe5e5b4dfe9f933aed37541217", "input": "We also discuss the functional consequences of the activities of these proteases on mammalian physiology and disease.", "output": [ "purpose" ] }, { "id": "task1163-e3656c5698f0417e90d1b3d3f1f14c3b", "input": "the battle against viruses has never ceased.", "output": [ "background" ] }, { "id": "task1163-a3bc95df52de44c3a52684fef3d3fd2c", "input": "• Coronavirus can cause severe immune thrombocytopenic purpura ( ITP ).", "output": [ "finding" ] }, { "id": "task1163-ac48c9611bef4d9c89391066d557bd4b", "input": "The purpose of this study was to generate mortality estimates among SARI patients that include deaths occurring shortly after hospital discharge and identify risk factors for mortality.", "output": [ "purpose" ] }, { "id": "task1163-03c2f3817e17430f8ef3cce1504ee444", "input": "with a view to standardizing concepts and measurements to enable future research to generate a cumulative knowledge base for policy and practice.", "output": [ "purpose" ] }, { "id": "task1163-b6ff044803d544c5ba44ef741a8ee722", "input": "Viral excretion peaked at 4 dpi and decreased to zero by 10 dpi.", "output": [ "method" ] }, { "id": "task1163-dca576004cdf47ddb66152cba2716ae0", "input": "we have performed RNA sequencing of viral genomic RNA to determine the precise sites of recombination in a series of recombinants which have crossovers within the gene encoding the peplomer protein.", "output": [ "method" ] }, { "id": "task1163-b7a76af15197448cb050484c49ff64e9", "input": "This review gives an overview of the advances of thread-based microfluidic diagnostic devices in a variety of applications.", "output": [ "purpose" ] }, { "id": "task1163-3180189ffe3341aa8db4809ef1a311b5", "input": "based on the latest evidence published in the literature.", "output": [ "purpose" ] }, { "id": "task1163-2be30b56704748eb80ffcf6914e01d5f", "input": "including health professionals , due to adverse health outcomes after a severe disaster.", "output": [ "background" ] }, { "id": "task1163-ce60391b5af640aeb2c888c711528fdd", "input": "In infancy , respiratory syncytial virus infection can induce bronchiolitis and set up recurrent wheezing over the next few years.", "output": [ "finding" ] }, { "id": "task1163-0ded26556330489da757db373671714a", "input": "Therefore , the purpose of the research was to evaluate the prevalence of feline hemotropic mycoplasmas and to characterize risk factors and clinical findings associated with these infections in a cat population from the Madrid area , Spain.", "output": [ "purpose" ] }, { "id": "task1163-c6d92f4e677e442da928681c4427c4dc", "input": "We found that some types of unusual viral RNA species were produced by infections with IFN-β-inducing viruses and accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner.", "output": [ "finding" ] }, { "id": "task1163-c89db51e56ad487c94e56f7457073ade", "input": "glycosylation , and transport of the lymphocytic choriomeningitis virus ( LCMV ) glycoproteins have been examined.", "output": [ "background" ] }, { "id": "task1163-b2413bb28ec848b49abb56b82c086020", "input": "The physician exhibited numerous furuncles.", "output": [ "background" ] }, { "id": "task1163-1a24de328dac47c6a73e1d0458f0e32d", "input": "In this report , we study the membrane topology of the SARS-CoV E protein by immunofluorescent staining of cells differentially permeabilized with detergents and proteinase K protection assay.", "output": [ "purpose" ] }, { "id": "task1163-1ca828271a944481a06ee605b36dc8cd", "input": "sampled from 1988 to 2014.", "output": [ "purpose" ] }, { "id": "task1163-d9e65b2fe11b4045aafd6f612fe2924b", "input": "that considerably guide viral replication after host infection in an orchestrated manner.", "output": [ "purpose" ] }, { "id": "task1163-de942225ee6f4292a75a1a35dac9c5bc", "input": "some of them frequently observed in IFN-treated patients.", "output": [ "background" ] }, { "id": "task1163-6d33aa78d81b4d908e2da7c1309d5d88", "input": "climate and land use changes.", "output": [ "purpose" ] }, { "id": "task1163-f641ce0fecac4542a1bee2c5621c172b", "input": "Supernatants of immortalized B cell clones containing monoclonal antibodies were screened for binding to HA proteins representing two different HA subtypes.", "output": [ "method" ] }, { "id": "task1163-8924ef81923f4cf79ffd2bd3099211e6", "input": "demonstrating the significant differences in model outcomes.", "output": [ "method" ] }, { "id": "task1163-5a201fa204bc46ce951300dc71a8b6fd", "input": "We consider the requirements for a standardized conceptual framework for future research capable of informing policy to reduce the morbidity and mortality impacts of such incidents.", "output": [ "purpose" ] }, { "id": "task1163-7d5d666a2d9045938b0411f0f362ab11", "input": "A review of the literature suggests that effective control of hospital outbreaks was accomplished in most instances by the application of proper infection control procedures.", "output": [ "finding" ] }, { "id": "task1163-8e50d11bf2764b8c8843168725cb34c0", "input": "high efficiency , and low toxicity.", "output": [ "background" ] }, { "id": "task1163-50057b9dc44141ad86471603d3e2dd71", "input": "This chapter focuses on variabilities amongst the spike ( S ) proteins of infecting virus strains.", "output": [ "purpose" ] }, { "id": "task1163-0ef0aeeae3a5448fab94707449b17114", "input": "Escherichia coli maltose binding protein ( MBP ) is employed as an N-terminal tag to increase the yield and solubility of its fusion partners.", "output": [ "method" ] }, { "id": "task1163-90ac08cdddc34a6482ca3feeb639c761", "input": "as well as guidelines on the diagnosis and management of CRV infections in patients intensively treated for hematological malignancies.", "output": [ "purpose" ] }, { "id": "task1163-7ebdc342ca594330b631360cb2549cd7", "input": "parvovirus , rubella and measles.", "output": [ "background" ] }, { "id": "task1163-65429eaa6b6645bfa6a44051f3acb28a", "input": "guanylyltransferase ( GTase ) and methylase activities were analysed by a series of in vitro biochemical assays using recombinant mutant proteins ; subsequently their effects on virus replication were assessed by introducing the same mutations in replicating viral genome using a reverse genetics system.", "output": [ "method" ] }, { "id": "task1163-679771986a5d4754aef61cc6cc57fe61", "input": "B12 , B15 and B19 haplotypes.", "output": [ "method" ] }, { "id": "task1163-b4cd6155a4ed4924b50bd6d1be367965", "input": "Here , we identified several nuclear factors from the cortex of control and OC43-infected mice which bind a fragment of the proximal ApoD promoter in vitro.", "output": [ "purpose" ] }, { "id": "task1163-28c530b44f904162a0e894583c538b97", "input": "and every other adjacent house starting from the social center was marked and respondents were interviewed using structured questionnaires.", "output": [ "method" ] }, { "id": "task1163-203bd39cf7624719a9fae4bd9dfae884", "input": "A 4-month-old boy was admitted to the pediatric ward of Saint-Vincent-de-Paul hospital ( Paris ) with a history of 3 days of cough and 1 day of moderate fever.", "output": [ "finding" ] }, { "id": "task1163-e07d7fe5cadd488e9d5c40dfc3f01cf3", "input": "which included 29 1st RSV-ARI and 31 2nd RSV-ARI.", "output": [ "finding" ] }, { "id": "task1163-e6021dd7cad14f88b4e409501403550e", "input": "We report the structure of Machupo virus ( MACV ) GP1 bound with human TfR1.", "output": [ "purpose" ] }, { "id": "task1163-9c4df9bbcdc0421480da51b3ecb566ee", "input": "it is important to understand how acute exacerbations evolve.", "output": [ "background" ] }, { "id": "task1163-f9094a0c88064133a01f6811b724cf6d", "input": "We assessed the emergency response of health care workers ( HCWs ) involved in case management.", "output": [ "purpose" ] }, { "id": "task1163-69c85eb02e1d4d029335f58899085958", "input": "multiplexed detection of unlabelled nucleic acids in solution.", "output": [ "purpose" ] }, { "id": "task1163-7d23c9d8808c4dfdb087fc8d6256a726", "input": "cell apoptosis , and interferon ( IFN ) signalling was studied by flow cytometric analysis and quantitative RT - ( q ) PCR using shBCN1-MDBK cells.", "output": [ "method" ] }, { "id": "task1163-153ed6376a0c40e48977f758c593bb0c", "input": "Pathogens were detected by multiplex reverse transcription polymerase chain reaction.", "output": [ "method" ] }, { "id": "task1163-96a763dda665424faa77f2401286904a", "input": "They are too effort intensive for stakeholders.", "output": [ "background" ] }, { "id": "task1163-a46a0167d84f40a692b978fe678bb277", "input": "we investigated how body TRS activity affected sg RNA synthesis from neighboring body TRSs.", "output": [ "purpose" ] }, { "id": "task1163-5b752b2a75f84767b680864bf81bf44b", "input": "Staffing patterns and nurses ' working conditions are risk factors for healthcare-associated infections as well as occupational injuries and infections.", "output": [ "background" ] }, { "id": "task1163-9d70ac6f1d424e4d8d272f72f751e5ec", "input": "which has a strong inhibitory effect on dsRNA-induced IFN-b production.", "output": [ "method" ] }, { "id": "task1163-7a334fcfeae244438082404485658f22", "input": "In this study , we have dissected the effects of PI3K-Akt-mTOR signaling pathway on rotavirus infection using both conventional cell culture models and a 3D model of human primary intestinal organoids.", "output": [ "finding" ] }, { "id": "task1163-7bf111ed01504656a8992cfa54e6df68", "input": "virtual drug screening and high-throughput screening to 35 identify new drug leads that target the COVID-19 virus main protease ( M pro ).", "output": [ "method" ] }, { "id": "task1163-a357de07c9f8488c84d1e9a17fc10c2b", "input": "hypoxiainduced pulmonary vasoconstriction is accompanied by an increase instead of a decrease in NO release.", "output": [ "finding" ] }, { "id": "task1163-5bb1c876d92f4a358474ca0da3ffb925", "input": "Longitudinal sections revealed that at nodes of Ranvier PNS-type myelin sheaths were apposed by either intact or newly formed CNS-type myelin sheaths.", "output": [ "finding" ] }, { "id": "task1163-f0b4f9976af0426c9aa8cb3eab7e8616", "input": "We employed population flow data from different sources between Wuhan and other cities/regions by 23 January 2020.", "output": [ "method" ] }, { "id": "task1163-f6ba5a975da74ceca1bf40152469e2bc", "input": "The biological implications of these findings for the MPA-mediated inhibition of members of the covalent nucleotidyl superfamily are discussed.", "output": [ "finding" ] }, { "id": "task1163-03e0d7ac59184114a15a1640db82338f", "input": "an etiological agent for many of these illnesses is rarely identified.", "output": [ "background" ] }, { "id": "task1163-9bb6df839b6e4a90b3369e984753ae64", "input": "These results revealed new insights on rotavirus-host interactions and provided new avenues for antiviral drug development.", "output": [ "finding" ] }, { "id": "task1163-5b9910b08d3d44629470ed25137a0512", "input": "Descriptive statistics were used to report demographic data.", "output": [ "method" ] }, { "id": "task1163-63fb149ab6684fc2a8198a492e3c8bda", "input": "B , O and Rh ( D ) blood groups and WNV clinical disease outcome.", "output": [ "method" ] }, { "id": "task1163-40e32df3ee2a42569ea0c52d9db56861", "input": "Note : this report is a pre-print and has not yet been peer-reviewed.", "output": [ "background" ] }, { "id": "task1163-1b2635a454ff4478a2f2ba1376a85f6e", "input": "Objectives : To explore the epidemiological and clinical factors predictive of the case fatality rate ( CFR ) of Middle East respiratory syndrome-coronavirus ( MERS-CoV ) infection in an outbreak in Daejeon , the Republic of Korea.", "output": [ "purpose" ] }, { "id": "task1163-ac7aa31804234e82935ad99e9f11c565", "input": "18-64 years of age , during the H1N1 2009 pandemic in Mexico.", "output": [ "purpose" ] }, { "id": "task1163-883ab9d007094d6a80b47b69d35f79f8", "input": "A cross-sectional survey among Malaysian Hajj and Umrah pilgrims in 2018.", "output": [ "purpose" ] }, { "id": "task1163-a0888f1db67044ce84fb58dc8bd38463", "input": "as well as possible approaches of utilization of abovementioned phenomenon for struggling against viral infections.", "output": [ "purpose" ] }, { "id": "task1163-fcd9edc172bc4221bfcdb1553559cc86", "input": "In this study , a multi-pathogens survey was conducted to verify the sanitary status of two Italian wolf packs of Majella National Park.", "output": [ "purpose" ] }, { "id": "task1163-93976e369c8f4643bc7ed3d2eab2c370", "input": "Methods : Proteome and histone lysine acetylation were profiled through stable isotope labeling for cell culture ( SILAC ) - based quantitative proteomics.", "output": [ "method" ] }, { "id": "task1163-e1d32fd34c074053ae1f4a1b91690409", "input": "we examine the impact of interventions on clinical attack rates rather than mortality.", "output": [ "method" ] }, { "id": "task1163-d4d1fdaf355b41d39ba06a10e1a80642", "input": "the bacterial pathogen Francisella tularensis proliferates within the cytosol of macrophages without demonstrable control by autophagy.", "output": [ "background" ] }, { "id": "task1163-bbd7a9c75c3a48dbabe0ea1ea9b3d73a", "input": "Moreover , nsp3 and E protein colocalized during the infection.", "output": [ "finding" ] }, { "id": "task1163-8c2ca0e4149641f79bca8e8157264dda", "input": "Saudi Arabia , over an almost 2-year period and local Arabian camels over 2 months in the year after surveillance of the port.", "output": [ "method" ] }, { "id": "task1163-e30923a99b5e49be95c835154a68cbf0", "input": "software architecture and implementation of HealthMap and discusses key challenges and future plans.", "output": [ "method" ] }, { "id": "task1163-80b8560c78e14192bab8e54d085fc4a2", "input": "The current COVID-19 pandemic is rapidly spreading around the world.", "output": [ "background" ] }, { "id": "task1163-b767e1c29c9843e9a663f7dba1889a42", "input": "This paper reviews the biochemistry of ACE2 and discusses key findings such as the elucidation of crystal structures for ACE2 and testicular ACE and the development of ACE2 inhibitors that have now provided a basis for future research on this enzyme.", "output": [ "purpose" ] }, { "id": "task1163-8b0a391fbfe24fcd91d8465c7b1880d5", "input": "Here , we highlight the most important hosttargeting strategies against hepatitis C and critically discuss their opportunities and risks.", "output": [ "purpose" ] }, { "id": "task1163-a5289ab2306b46eca506ea57c442b6ca", "input": "incidence and clinical features of PIV-associated infections diagnosed during the hospital stay of patients admitted to pediatric intensive care unit ( PICU ) and intensive care unit ( ICU ) of 5 medical centers across Kuwait.", "output": [ "purpose" ] }, { "id": "task1163-9b29e95fa95e403b8e209ca505769123", "input": "A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses.", "output": [ "background" ] }, { "id": "task1163-fe0fdb11efe84715a07aaa7564e7f359", "input": "Serum was analyzed for BCoV antibodies.", "output": [ "method" ] }, { "id": "task1163-9d8fc53ac04c4645afefe25662e74fb4", "input": "For Case 2 , the most likely source could not be determined.", "output": [ "finding" ] }, { "id": "task1163-aee97ed535d04edcac317c5f31c79d5e", "input": "and 4 % administered aerosolized medication.", "output": [ "finding" ] }, { "id": "task1163-ba3a899c419b4ca08b7af725ed7af4b4", "input": "not only after nuclear disasters but also in other circumstances.", "output": [ "finding" ] }, { "id": "task1163-2f7a068e207540f2adb96fe51a8994c5", "input": "the oxygenation index and C-reactive protein ( CRP ) levels in patients with severe pneumonia.", "output": [ "purpose" ] }, { "id": "task1163-a0757acb5ff54da5a4ccbadd12ca31a0", "input": "Objectives : To investigate the detection rates of bovine coronavirus ( BCoV ) in feces of healthy and diarrheic calves and to describe the usefulness of a pancoronavirus reverse transcriptase ( RT ) PCR ( PanCoV-RT-PCR ) assay to identify BCoV in samples of diarrheic calves.", "output": [ "purpose" ] }, { "id": "task1163-fe667c9bbbb441df91cd9b223c1574ee", "input": "and therefore , might represent more reliable indicators of disease activity in future outbreaks.", "output": [ "finding" ] }, { "id": "task1163-3df3dcc37b5945e4a403c8e6ed69f9f3", "input": "Aim : To compare the performances of molecular and non-molecular tests to diagnose respiratory viral infections and to evaluate the pros and contras of each technique.", "output": [ "purpose" ] }, { "id": "task1163-6dc1bd39162b414e999c61e8a46cca2e", "input": "In the present study , we performed a clinical study to apply our TCI formulation for vaccination against tetanus and diphtheria in human.", "output": [ "purpose" ] }, { "id": "task1163-1c653b5344d443ff9ade7a538fd6cef0", "input": "The experiment was conducted for two main scenarios ; human-computer interaction scenario and health monitoring scenario.", "output": [ "method" ] }, { "id": "task1163-82b68e8a5d0a42deb03e1834831b9556", "input": "Results : Median age of patients was 12 months.", "output": [ "finding" ] }, { "id": "task1163-b187c66187c54b1d8960bd7b87652c67", "input": "suggesting that the interaction between nsp3 and E protein may play a role in the E protein ubiquitination status and therefore on its turnover.", "output": [ "finding" ] }, { "id": "task1163-f74f8f549704427188aa78da0e088a7a", "input": "exhibiting no noticeable morphological changes.", "output": [ "finding" ] }, { "id": "task1163-8fd17e889c384aca9d53427ee1b5c449", "input": "The rates of fall-related attendance have been increasing and still remain high.", "output": [ "finding" ] }, { "id": "task1163-1d2ab13644cd467991e43d1ac1ac7c39", "input": "Blue and red boxes indicate positions of those putative elements and related transcription factors predicted by GPMiner.", "output": [ "finding" ] }, { "id": "task1163-fcc021a2aadd42b5b4df3bf69b53ed2f", "input": "A B S T R A C T Interferons ( IFN ) are key cytokines with multifaceted antiviral and cell-modulatory properties.", "output": [ "background" ] }, { "id": "task1163-94fee8b2f45c4af398b7c187dbdb9d01", "input": "and discuss current and future possibilities in using these routes as a means to improve therapeutic delivery.", "output": [ "purpose" ] }, { "id": "task1163-d5936db650074a3283387f1e79a32034", "input": "The aim of this study was to identify the CPV-2 subtypes detected in diagnostic specimens and rule out occult shedding of CPV-2 vaccine strains.", "output": [ "purpose" ] }, { "id": "task1163-823c35c7fd744cbabaf2bf8843f83457", "input": "lectin-glycan recognition , pathogen-host interactions and hierarchical signaling cascades.", "output": [ "purpose" ] }, { "id": "task1163-ddbfb2d148f6481583cd6fb9fd0a4c9d", "input": "There is still no vaccine or definitive treatment for this virus because its pathogenesis and proliferation pathways are still unknown.", "output": [ "background" ] }, { "id": "task1163-0e97d0362e424d4f8f85c53384671906", "input": "HIV-1 Tat protein is an important pathogenic factor in HIV-1-associated neurological diseases.", "output": [ "background" ] }, { "id": "task1163-f47c4181057844918c72a50657aa10a0", "input": "the nucleotide sequence of the 5 ' - unique regions of mRNAs 4 and 5 were determined from cloned cDNAs.", "output": [ "background" ] }, { "id": "task1163-e088d82373d24e6ba401a104d91a0579", "input": "Airport screening is unlikely to detect a sufficient proportion of 2019-nCoV infected travellers to avoid entry of infected travellers.", "output": [ "background" ] }, { "id": "task1163-3093197b38074464bbbe8b108c3c8150", "input": "This concept has been verified recently in a pilot study with human cells which had been rendered transgenomic for a 5.6 kbp bacterial plasmid.", "output": [ "finding" ] }, { "id": "task1163-58c9818db4294a26bf797d3d7fc9fec4", "input": "Sequence analysis showed some viruses to be related to IBV.", "output": [ "finding" ] }, { "id": "task1163-3744af85aae541dd953d354da7a31b6a", "input": "and their eff ect on childhood asthma.", "output": [ "purpose" ] }, { "id": "task1163-d871c6dcd3094c5e936af0aff3e927eb", "input": "R 0 , is the number of secondary infections which one infected indi-102 vidual would produce in a entirely susceptible population.", "output": [ "method" ] }, { "id": "task1163-c852410e19294f648508e55cd1ebc6e2", "input": "However , the possible transmission of SARS-CoV-2 by conjunctiva is controversial.", "output": [ "background" ] }, { "id": "task1163-6e1934b71c284183b9414cc642daf978", "input": "Three-dimensional analyses indicated that half of the originally discovered 1,7-DAAC structure superimposed well with 4-amino-7-chloroquinolinebased antimalarial agents.", "output": [ "background" ] }, { "id": "task1163-68458ad9b4a34fc980fd23ef5d22b978", "input": "Here we study the impact of human mobility on HIV transmission in different parts of Kenya.", "output": [ "purpose" ] }, { "id": "task1163-16795808e9724cc982460c65f766779b", "input": "both theoretical and managerial applicability of the proposed stage-based model are empirically verified in this study.", "output": [ "method" ] }, { "id": "task1163-8cbc401f6e24444b8b382d53958c7784", "input": "Methods : We calculated the time lag and correlation between ILI incidence ( from ILI sentinel surveillance , based on general practitioners ( GP ) consultations ) and percentages of ICU admissions with a respiratory infection ( from the Dutch National Intensive Care Registry ) over the years 2003-2011.", "output": [ "method" ] }, { "id": "task1163-b6c2bb87440941d5819ae078b1d6aedd", "input": "All persons who could taste the commercial solution could taste homemade solution.", "output": [ "finding" ] }, { "id": "task1163-49f2b7e6aa3248e8966eb8ad3988307a", "input": "Nicaragua ( 192 ) and Peru ( 191 ) were tested.", "output": [ "finding" ] }, { "id": "task1163-b8397ee4793c42b9a9f78aff81ad4050", "input": "We examined the CoVs circulating among wild birds in Finland.", "output": [ "purpose" ] }, { "id": "task1163-d6044dbc4b224c01a9d819bf3f37d5e3", "input": "IgHCDR3 regions were defined with their Kabat numbering using the software available on the Abnum website ( http://www.bioinf.org.uk/abs/abnum/ ).", "output": [ "method" ] }, { "id": "task1163-fde1540ebf6b4a2c9901a1b655d84c7a", "input": "variations were only observed in the levels of specific IgY which depended rather on the age of ducks at the time of infection than on the infectious dose.", "output": [ "finding" ] }, { "id": "task1163-4db7c2b8faba47cca1414f2a27669244", "input": "is an emerging swine enteropathogenic coronavirus ( CoV ).", "output": [ "background" ] }, { "id": "task1163-c307521b5c194049b2dad13cb8cfcbcd", "input": "Objectives : To describe the epidemiology and etiologies of respiratory illnesses among pilgrims returning to Jordan after the 2014 Hajj.", "output": [ "purpose" ] }, { "id": "task1163-b28eb50dce254b05b086d38c6b1e8d26", "input": "parental atopic illnesses , and parental smoking.", "output": [ "method" ] }, { "id": "task1163-c4191eb72c0445f29511ccb2aaa6aed7", "input": "for the detection of 14 respiratory viruses.", "output": [ "method" ] }, { "id": "task1163-a81393cd48dd485eb97d148013003aaa", "input": "lethal respiratory disease occurring across several countries in the Middle East.", "output": [ "background" ] }, { "id": "task1163-c48d05df7a8644098cebab5893e06c87", "input": "and the data collection ended on March 17 2020.", "output": [ "method" ] }, { "id": "task1163-b99abda6664042a791cce09c41c85e44", "input": "Data were collected from 25 th January to 28 th February 2020.", "output": [ "method" ] }, { "id": "task1163-ab62c79861a64019a39e555f5d30cbd3", "input": "leaving the axons denuded , and at the same time astrocyte endfeet at the glial limiting membrane were swollen and partly destroyed.", "output": [ "background" ] }, { "id": "task1163-61294aebc9894a0f82798602163643f7", "input": "Therefore , there is a need for the development of a rapid and sensitive diagnosis of respiratory viral pathogens.", "output": [ "purpose" ] }, { "id": "task1163-d6f1122820a04f8299ad797d56ffc255", "input": "were deemed controlled if transmission ended within 12 weeks or before 5000 cases in total.", "output": [ "method" ] }, { "id": "task1163-f907800d27cc4bbaa4243a9564dab472", "input": "successful and unsuccessful of such a journey.", "output": [ "purpose" ] }, { "id": "task1163-4529a800fc15444792d861aa107ae362", "input": "the receptor for Deltacoronavirus is unclear.", "output": [ "background" ] }, { "id": "task1163-f65bcb2159ac415494f82905a4ed3a8a", "input": "The propagation of a mouse-adapted strain ( 67N ) of haemagglutinating encephalomyelitis virus in infected mice and murine cells was examined by viral re-isolation and immunostaining.", "output": [ "method" ] }, { "id": "task1163-9e56f484e1b74370b45848b2dae726e3", "input": "Pentoxifylline was able to inhibit JEV replication in a dose-dependent manner at a 50 % inhibitory concentration ( IC 50 ) of 50.3 g/mL ( 0.00018 M ) and a therapeutic index ( TI ) of 10.", "output": [ "finding" ] }, { "id": "task1163-4cd162b7a13b42bfbc014ffda506906d", "input": "3943 ( 90.3 % ) of whom were assigned a travel-related diagnosis.", "output": [ "method" ] }, { "id": "task1163-dd3e375b4e95455b98eed8c2ac860ce7", "input": "A cross-sectional study was conducted among paediatric patients aged 2-13 years with dengue in Yankin Children Hospital , Myanmar.", "output": [ "method" ] }, { "id": "task1163-597f55edfd684fb382a2abc808808be1", "input": "Objective : To survey fertility patients ' agreement with ASRM recommendations during the pandemic and the emotional impact on them.", "output": [ "purpose" ] }, { "id": "task1163-cbcb886a090948e7b578ae6f55535612", "input": "phylogeny and antibody titres against parvoviruses were investigated in the positive cats.", "output": [ "method" ] }, { "id": "task1163-1c4a4b86731d47828ac983f5901b3dea", "input": "It has been shown that autophagy interacts with both adaptive and innate immunity.", "output": [ "background" ] }, { "id": "task1163-deaf0e036c304e6d8caff3a83dfbafdb", "input": "We therefore evaluated the effects of PTH on improving the effects of CD in Early-Stage SAON.", "output": [ "purpose" ] }, { "id": "task1163-dad0c4b04dbd49fc8b8428e6d5cc87e1", "input": "Databases and computational tools for mimotopes have been an important part of phage display study.", "output": [ "background" ] }, { "id": "task1163-b511f21c0f6147d48e955558a30a3d5a", "input": "were better remembered and retained in the participants ' memory.", "output": [ "finding" ] }, { "id": "task1163-15f89f717f7d404f955c8031b04d5cbf", "input": "As examples , cellular syntheses of dimers of ( GB1 ) 2 ( where GB1 stands for immunoglobulin-binding domain B1 of streptococcal protein G ) and of four-arm elastin-like star proteins were demonstrated.", "output": [ "background" ] }, { "id": "task1163-1acfa336e4dc4ba3ab5dd7bd3d8ddc4a", "input": "Here , we identify the essential cytokinetic formin Cdc12 as a key CR substrate of SIN kinase Sid2.", "output": [ "purpose" ] }, { "id": "task1163-e80f39b21d4345c49f1aeaec034fab3e", "input": "to our knowledge , of SARS in a naval diver.", "output": [ "purpose" ] }, { "id": "task1163-62eafccdec394e789f4d4347aa0e987a", "input": "multi-resistant Gram-negative pathogens , mycobacteria or respiratory viruses may be involved.", "output": [ "finding" ] }, { "id": "task1163-e04829824134443e89164ba03d3b7348", "input": "most viruses require the modification of their tropism to specifically enter and replicate in such cells.", "output": [ "background" ] }, { "id": "task1163-0c249618a68c4b92a7d5db3edba781ec", "input": "the novelty of our approach is the inclusion of fuzzy integral with Markov chain for sequence analysis in the alignment-free model.", "output": [ "purpose" ] }, { "id": "task1163-112338f894824d33a118dc55707fbb54", "input": "We sought to characterize the relationship of the translated proteins of 2019-nCoV with other species of Orthocoronavirinae.", "output": [ "purpose" ] }, { "id": "task1163-f4a05cc01d474cb8a217be8a0027e2a9", "input": "and the advantages of pulmonary vaccination are discussed.", "output": [ "method" ] }, { "id": "task1163-dc6337ad7af34166abd1854f39f36f18", "input": "Installation of protective shields on slit lamps were implemented and surgical masks were worn by both ophthalmologists and patients.", "output": [ "method" ] }, { "id": "task1163-5323d9fe5b14458fba4b35901ca02e09", "input": "We then compared bioactivities of these two recombinant proteins.", "output": [ "method" ] }, { "id": "task1163-7b79029457d449b78fb1037112e897b6", "input": "Association between BCoV and health status was evaluated by exact and random effect logistic regression.", "output": [ "method" ] }, { "id": "task1163-f2f4b880de65468c9711d096c2fa8e15", "input": "and since there are now a number of high resolution x-ray structures of SARS-CoV 3CLpro available making structure-based drug-design possible.", "output": [ "background" ] }, { "id": "task1163-cdea1bf5e8cd481195d82ae2ec527d2b", "input": "No medications were associated with an increase or decrease the likelihood of the infection.", "output": [ "finding" ] }, { "id": "task1163-18d0d9f191494bae9bc7b7ff621d2587", "input": "Logistic regression was used to assess the risk of MERS-CoV infection among the suspected cases.", "output": [ "method" ] }, { "id": "task1163-08cf4198de1a449792bab39807d25a33", "input": "removal or deactivation of the catalyst will convert the DCL into a static mixture.", "output": [ "finding" ] }, { "id": "task1163-265ed70cbec441f69c4ddbac63f0b105", "input": "This animal model has the potential to recapitulate the potential neuropathogenicity of SAFV-3.", "output": [ "finding" ] }, { "id": "task1163-e42933c5806147da8ae3764869f3c99d", "input": "We report the development of RT-PCR tests that distinguish live FluMist TM vaccine ( FMV ) strains from circulating influenza strains in clinical samples.", "output": [ "purpose" ] }, { "id": "task1163-2292be77961f487583189ef536da7173", "input": "It is believed that CD4 + T lymphocytes play an important role in the pathogenesis of this disease by mediating the demyelination of neuronal axons via secretion of proinflammatory cytokines resulting in the clinical manifestations.", "output": [ "background" ] }, { "id": "task1163-585d3b296d4c4c659786e3f80c39a5d7", "input": "In this article , we propose two well-defined distance metrics of biological sequences based on a universal complexity profile.", "output": [ "purpose" ] }, { "id": "task1163-2c487f55ef05405e8a7430e7c4ff2b76", "input": "Clade 2 comprised six proteins exclusive to Sarbecovirus and Hibecovirus.", "output": [ "finding" ] }, { "id": "task1163-cc3a16c59fe54a96ad4c526936c4ddb1", "input": "The G protein has an amino-terminal signal sequence and a stop-transfer sequence located near the carboxy terminus.", "output": [ "background" ] }, { "id": "task1163-ac5b4df7d7c14d6fb3a478e944f9b5e1", "input": "Results : The results showed that 179/217 ( 82.5 % ) samples were positive with the singleplex method and 183/217 ( 84.3 % ) with the FTD ® Respiratory Pathogens 33 multiplex test.", "output": [ "finding" ] }, { "id": "task1163-e23794bfd91d407b99d6b0623d5f70ed", "input": "epidemiological status of the individuals , and intervention measures.", "output": [ "method" ] }, { "id": "task1163-73c1c9d0c58f49579c71f560e140607c", "input": "For control of influenza , firstly it is important to find the real virus transmission media.", "output": [ "background" ] }, { "id": "task1163-85581f9175eb428992d8ae87c7c06599", "input": "and tRNA cleavage among others.", "output": [ "background" ] }, { "id": "task1163-808954dd76464158b35ae8c68f5961a4", "input": "His respiratory status worsened , and after about 5 h he was intubated.", "output": [ "background" ] }, { "id": "task1163-102c4f3297aa4349bdc80bf7f1685fe1", "input": "Only CDV was significantly more prevalent in CAI than HAI dogs.", "output": [ "finding" ] }, { "id": "task1163-e7e80400d71746eea44d43b2b2c41d0d", "input": "The primary endpoints were laboratory-confirmed bacterial colonisation and viral respiratory infection.", "output": [ "method" ] }, { "id": "task1163-b15fd745d62e47459fdc72b7d7af40a5", "input": "Here , we propose fully 34 differentiated human airway epithelium cultures as a model for studies on the SARS-CoV-2.", "output": [ "purpose" ] }, { "id": "task1163-4729ccff459241f8879440e095892268", "input": "We have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal studies.", "output": [ "purpose" ] }, { "id": "task1163-3df8e8f02acc4d68a56099ac8d1cc19c", "input": "the approach constructs a panel of contiguous cDNAs that span the DENV genome and can be systematically and directionally assembled to produce viable , full-length viruses.", "output": [ "method" ] }, { "id": "task1163-61dfafa1584a4ab6aabd455feb57dfc6", "input": "This pilot was conducted evaluation comparing performance characteristics of the RT-PCR and Electrospray Ionization Mass Spectrometry ( RT-PCR/ESI-MS ) platform to conventional virological methods for identifying multiple clinically relevant respiratory viruses in nasopharyngeal aspirates.", "output": [ "purpose" ] }, { "id": "task1163-240ba48e06624d03945daf30c546672f", "input": "The objective of this study was to determine if the period of these infection control measures was associated with changes in overall population mortality due to causes other than SARS.", "output": [ "purpose" ] }, { "id": "task1163-142ecd3e2c854750bfd1406893df8343", "input": "Cell surface expressed protein binding assays were conducted using flow cytometry to detect binding of antibodies to HA transfected cells.", "output": [ "method" ] }, { "id": "task1163-366ff6b78a874fbba22748b3a9d3dbc9", "input": "This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats.", "output": [ "finding" ] }, { "id": "task1163-c4a2d0ba73d248bcab6f0badea2590f0", "input": "These data help us to identify important contributors to death that may be remediated through quality assurance and control programs.", "output": [ "purpose" ] }, { "id": "task1163-58de0ec200ab4e56a51c85c7053553ae", "input": "These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.", "output": [ "finding" ] }, { "id": "task1163-3db281937b27464a872a2567961357e0", "input": "with a case fatality rate of 5-15 % for HFRS and up to 40 % for HCPS.", "output": [ "background" ] }, { "id": "task1163-d6787ad2a5264d178357bbd58a678ada", "input": "Results : All patients are passengers without flight attendants.", "output": [ "finding" ] }, { "id": "task1163-1963ddcd612a4e979eb74ba6543d0e49", "input": "propels research towards the development of a suitable vaccine candidate.", "output": [ "finding" ] }, { "id": "task1163-77898900deb84a588cfc93ba550295dd", "input": "and 31 low frequency codons inclined to end with C or G in these four species and four subgenomes.", "output": [ "finding" ] }, { "id": "task1163-8db1141bd3b0443da890d1b8c9b5265b", "input": "using a bacteriophage surrogate for pathogenic organisms.", "output": [ "purpose" ] }, { "id": "task1163-912b3cc347634541942fb8e8109cabb8", "input": "Referring to specific clinical symptoms of pulmonary plague the disease became known as the Black Death.", "output": [ "background" ] }, { "id": "task1163-967104fb0a824abc90aad3d372696cb8", "input": "None of the top 5 % most ELISA reactive livestock samples were positive for HCoV-NL63-related viruses by immunofluorescence confirmation.", "output": [ "finding" ] }, { "id": "task1163-9a31cf51e5cf48da913339adce59717c", "input": "distribution , and location of G-quadruplexes are features characteristic of each virus class and family.", "output": [ "finding" ] }, { "id": "task1163-a54fc476240943c0b2ab2b3941e2386b", "input": "significant advances have been made recently with several hamster specific immunologic methods being developed.", "output": [ "background" ] }, { "id": "task1163-c7380439a3b24ce2b585f4b5a6b4ca6c", "input": "we initially used a green fluorescent protein ( GFP ) to tag the antigen in transient expression.", "output": [ "method" ] }, { "id": "task1163-927faad864044a8eb2b2179ac3482029", "input": "In this study , we assessed the feasibility of producing a protective antigen for the PEDV spike protein 1 using duckweed , Lemna minor.", "output": [ "purpose" ] }, { "id": "task1163-061d7c4cae6b462bb6969ea7c334b6cb", "input": "Electron-microscopic analysis was used for the identification of caveolae.", "output": [ "method" ] }, { "id": "task1163-c33209e11aa946a38d10aaecea049df5", "input": "In this study we used high temporal and spatial resolution animal position data to construct a high-resolution contact network relevant to infectious disease transmission.", "output": [ "purpose" ] }, { "id": "task1163-b171f95cff1747078ebb328238654eea", "input": "Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals.", "output": [ "background" ] }, { "id": "task1163-5a267e4e9021405cb31abee8e7bf87cb", "input": "leaving only the untagged recombinant protein in the column effluent.", "output": [ "method" ] }, { "id": "task1163-89eb7dfb390b4d36bc86ea65e07f51e4", "input": "United States , which is a state with large urban centers as well as a sizeable rural and agricultural population.", "output": [ "background" ] }, { "id": "task1163-c60ab497a55d4b4c86c5fb521c9ecd7a", "input": "Objectives Our study aimed to estimate the frequency of human bocavirus ( HBoV ) infection among pediatric populations in Argentina , Nicaragua and Peru.", "output": [ "purpose" ] }, { "id": "task1163-6c7df59459c2492a9af5d5be71831df5", "input": "In the first decade of democratic rule in South Africa scheduled commercial passenger flights across the countryÕs borders more than doubled.", "output": [ "background" ] }, { "id": "task1163-f38c5c3184c44e04bcf107c8fd8c224c", "input": "All vaccinated groups appeared to be protected based on body weight gain and lesion scoring.", "output": [ "finding" ] }, { "id": "task1163-bb93508f8b414504b10891bb72b454bc", "input": "These patients travelled with a group of 29 other Dutch travellers.", "output": [ "background" ] }, { "id": "task1163-374316c9df4140fdbe433dda9c62f284", "input": "Here , we describe the epidemiology and genotype distribution of HAdVs associated with RTIs in Beijing , China.", "output": [ "purpose" ] }, { "id": "task1163-4d3470d4c5104b6ea2dfb3b79203cc4d", "input": "We describe the clinical and virologic features of URIs that remain uncomplicated and those that precede an episode of sinusitis.", "output": [ "purpose" ] }, { "id": "task1163-60daccb4d3c542299e7b3a20f29d57ec", "input": "and 3.7 L of distilled water were added to the RNA-primer mixture.", "output": [ "method" ] }, { "id": "task1163-0b449ec294d74ac58a69a9e3ef0396c0", "input": "Our findings therefore suggest that ITIS is unlikely to be effective for entry screening of travellers to detect influenza infection with the intention of preventing entry of the virus into a country.", "output": [ "finding" ] }, { "id": "task1163-6b2ccd01737a423ab5b771d865257f96", "input": "Colostral Ig preparations designed for farm animals have been commercially available for many years.", "output": [ "background" ] }, { "id": "task1163-d8aece6cb12e43a99c8cea5d234563fb", "input": "Theiler 's murine encephalomyelitis virus infection of susceptible strains of mice is an example of viral infections of the CNS as a prerequisite for demyelination.", "output": [ "purpose" ] }, { "id": "task1163-6ccf79aa536c4b548218fe250f2976fc", "input": "We assumed isolation prevented all further transmission in the model.", "output": [ "method" ] }, { "id": "task1163-1e9b9758f7704c5a98ab9a33cd824f12", "input": "bringing together key international players in the field and Singapore-based researchers and clinicianscientists.", "output": [ "purpose" ] }, { "id": "task1163-c6882b20a6ea4349a7e046d41bdf4b5d", "input": "The absence of a-casein also significantly inhibits transcription of the other casein genes.", "output": [ "method" ] }, { "id": "task1163-aebfb4d2ccd04f9f8611b39924607666", "input": "Taken together , these results reveal that Tat directly transactivates Egr-1 expression and suggest that Tat interaction with Egr-1 is probably one of the very upstream molecular events that initiate Tat-induced astrocyte dysfunction and subsequent Tat neurotoxicity.", "output": [ "finding" ] }, { "id": "task1163-0364b58efd404c7f945e04e9bb34a5a7", "input": "This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues.", "output": [ "purpose" ] }, { "id": "task1163-22fb1de939a9461789f2dd0fcc4543c4", "input": "associated with a reactivation of an EBV infection.", "output": [ "purpose" ] }, { "id": "task1163-5ff37356cb2641d6a2d19aed754abc91", "input": "Our principal objective is to develop an integrated approach to the surveillance of pathogens circulating in both human and animal populations and assess how frequently they are exchanged.", "output": [ "purpose" ] }, { "id": "task1163-5135a50930ba421ca2f6bc8ff4e64bf9", "input": "The accuracy of the keu SST turbulence model in detecting air flow around a rectangular block is validated by comparing it with the data from the wind tunnel experiment.", "output": [ "method" ] }, { "id": "task1163-00bdd4ca8e9c48319eea604b6e9a1973", "input": "Here we report comparably high positivity of MERS-CoV antibodies in dromedary camels from northern Mali.", "output": [ "purpose" ] }, { "id": "task1163-98ed73ad29d04c74a86ff890dd4a6847", "input": "Understanding the transmission pattern of the virus and the efficacy of transmission control measures is crucial to ensuring regional and global disease control.", "output": [ "purpose" ] }, { "id": "task1163-4378be552e474f4b87a08e07a05e398d", "input": "and 40 reported direct skin-to-skin contact.", "output": [ "finding" ] }, { "id": "task1163-f0eeb1bd71c1456a9e65ef896dc42f87", "input": "e.g. HCV , SARS-CoV , HSV-1.", "output": [ "background" ] }, { "id": "task1163-b07c9480aa7240b5af4685cf8fe3c2e7", "input": "Motivation : Accurately determining the atomic structure of proteins represents a fundamental problem in the field of structural bioinformatics.", "output": [ "background" ] }, { "id": "task1163-e4c9e68c11234ef29206d594bf4907a6", "input": "and the levels of control measures.", "output": [ "finding" ] }, { "id": "task1163-178ae4f588cc48798c074a721e63eaf0", "input": "The predicted start and end of influenza epidemics were compared with observed start and end of such epidemics according to the incidence of ILI.", "output": [ "method" ] }, { "id": "task1163-93a7dead0d854cff89e808f219969616", "input": "This study completes our active surveillance work on Spanish bat colonies that began in 1992.", "output": [ "purpose" ] }, { "id": "task1163-853a932099f14be8928a35d2549cd813", "input": "laboratories , daycare centers and residential care homes for the elderly.", "output": [ "method" ] }, { "id": "task1163-48baf627c4724901aa7b6f1c88bdedf4", "input": "Here , we will review the most recent findings on the interaction of SARS-CoV and related Coronaviridae members with the type I interferon and cytokine responses and discuss implications for pathogenesis and therapy.", "output": [ "purpose" ] }, { "id": "task1163-5e95cfa5de714ecbb13db2fae27e24a7", "input": "and had remarkably longer in vivo half-life than T20.", "output": [ "finding" ] }, { "id": "task1163-541df3262fbe40c48c937d4e3481b269", "input": "involves the production of brazzein in E. coli as a fusion with SUMO.", "output": [ "finding" ] }, { "id": "task1163-f29f3fa0ef574ba2a080725f1fce3bf2", "input": "Computational docking studies indicated that in all binding poses ATA binds in the YopH active site.", "output": [ "finding" ] }, { "id": "task1163-da012c08da7e41a194f5815e5c409ab5", "input": "This study surveyed the prevalence of HCoV-NL63 and influenza viruses in patients with influenza-like illness in Taiwan during 2010 e2011.", "output": [ "purpose" ] }, { "id": "task1163-9b57964401444f9abe268a436db79beb", "input": "Quantitative fit testing requires the purchasing and use of fit testing solutions and associated equipment.", "output": [ "background" ] }, { "id": "task1163-bccf03cde18a43be869c18959361e132", "input": "and 44 healthy adults , we measured the total number of natural killer ( NK ) and CD158b + NK cells ( CD158b + NK ) using flow cytometric analysis and calculated the percentage of CD158b + NK cells.", "output": [ "method" ] }, { "id": "task1163-79bc9c9a816b45e3b28912306a48a5ce", "input": "and mouse hepatitis virus ( MHV ).", "output": [ "method" ] }, { "id": "task1163-864adcd375bc4005a80c401165d062ce", "input": "These 28 samples were categorized into cohorts E ( < 14 dpd , acute phase ) and F ( > 14 dpd , convalescent phase ).", "output": [ "method" ] }, { "id": "task1163-17c106b27ddd44b6a716322a3f4a6712", "input": "and 77.76 ± 12.53 % of total reads respectively.", "output": [ "finding" ] }, { "id": "task1163-104e6ad3c47b4badbb07d6b6d26bc0d5", "input": "No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy.", "output": [ "background" ] }, { "id": "task1163-263696da0953481fb72673de7468e9cc", "input": "Results : Overall , 273 absences > 7 days were recorded and 36 clusters of at least two absences > 7 days were identified ; a total of 94 HCW were involved in these clusters.", "output": [ "finding" ] }, { "id": "task1163-ad522fb2e0a14214ae786f499c7756e7", "input": "which is termed as `` immunosenescence ''.", "output": [ "background" ] }, { "id": "task1163-a089e4742155448d99275d3b63f8a3e1", "input": "We hypothesized that population level usage of face 39 masks may be negatively associated SARS CoV-2 spread.", "output": [ "purpose" ] }, { "id": "task1163-f33503247c5a43aa84408cad07f7b1bd", "input": "Here we provide an overview of the current understanding of viral-induced autoimmunity and the mechanisms that are associated with this phenomenon.", "output": [ "purpose" ] }, { "id": "task1163-9c9c44f65806477aa64c1f179740d6e4", "input": "the organisational learning which had occurred.", "output": [ "purpose" ] }, { "id": "task1163-f639d3f0eac14a3f90bc6b6f8a220a03", "input": "β2microglobulin , and heavy chain of a MHC class I molecule connected by flexible linkers.", "output": [ "method" ] }, { "id": "task1163-4668a0bc7ea34328b1f5244f6a35bf68", "input": "whereas the integrated viral genomes become de novo methylated in specific patterns.", "output": [ "background" ] }, { "id": "task1163-bb85e42ec4204b7a881682554e999222", "input": "The objective of this report is to analyze the value of CMV viral load ( VL ) in bronchoalveolar lavage ( BAL ) in recipients of allogeneic hematopoietic stem cell transplantation ( AHSCT ) and to analyze the concordance between CMV quantification in plasma and BAL samples.", "output": [ "purpose" ] }, { "id": "task1163-e8b234cc12534a709566cf8e201e9d12", "input": "which together possess 22 potential N-glycosylation sites.", "output": [ "background" ] }, { "id": "task1163-711c2cf552074233b3b018c8a61e3eec", "input": "12 ( 80 % ) occurred during the first 2 weeks after ICU admission.", "output": [ "finding" ] }, { "id": "task1163-dad161c97d1e4ae59ccfa2ea0c8113a8", "input": "Here , we describe a novel vaccine that protects against emerging CHIKV infection of non-human primates ( NHP ).", "output": [ "purpose" ] }, { "id": "task1163-cf2efce0e59242a6b58b7f15a266a0f3", "input": "Here we describe an efficient strategy for the construction of a large naïve phage-display human Fab library with one-step cloning.", "output": [ "purpose" ] }, { "id": "task1163-3029e63279ce46ad90ab653463db4f83", "input": "We developed a multiplex asymmetric reverse transcription ( RT ) - PCR assay that can simultaneously differentiate all influenza A virus epidemic subtypes.", "output": [ "purpose" ] }, { "id": "task1163-a3e89c4da9614a2b9764d4ffeccc0284", "input": "We provide the first large-scale epidemiological analysis of ARDS incidence and outcomes in Asia.", "output": [ "finding" ] }, { "id": "task1163-9ba756da21144c4c9b7bc0852b8ac70d", "input": "R 0 , of 2019-nCoV in the early phase of the outbreak.", "output": [ "background" ] }, { "id": "task1163-f3550508d77c4fdca02172a845f84441", "input": "biodistribution , and potential for genomic DNA integration in normal vaccinated rodent.", "output": [ "purpose" ] }, { "id": "task1163-ba80a6b287794fb098362268029838d1", "input": "and blood samples from 828 residents during November 2015 and December 2015-January 2016.", "output": [ "method" ] }, { "id": "task1163-651f2a1d703548c3b221e994fc0b2310", "input": "Fathead Minnow Nidovirus , and Viral Hemorrhagic Septicemia Virus.", "output": [ "finding" ] }, { "id": "task1163-9b58a1d8ddfe4485bffbe7a0a05e742f", "input": "Multiplex immunoassay can be readily realized by using yeast cells expressing different intracellular fluorescent proteins to display different antigens.", "output": [ "method" ] }, { "id": "task1163-c28d5c8b4c8242878d17ab0ea3f519a7", "input": "Finally , by temperature block experiments we have determined that maturation of GP-C oligosaccharides to an endoglycosidase H resistant form precedes cleavage to GP-1 and GP-2.", "output": [ "finding" ] }, { "id": "task1163-0f3a00aeae1d4fc48c1dcf4276708622", "input": "In this trial 40 Holstein calves were randomly assigned to receive milk replacer with a prebiotic supplement ( 20 g/day Prebio Support ™ ; Meiji Feed Co. , Ltd..", "output": [ "method" ] }, { "id": "task1163-d29c91a550d74fe4bc5d2dc3602c55bb", "input": "Time series modeling of long-term historical EMR data can reduce the time it takes to discover epidemics of ARI.", "output": [ "finding" ] }, { "id": "task1163-93de3e7578084a39969bcc8c2118a0c6", "input": "deficiency could largely be compensated by Ly49Hmediated antiviral NK cell responses.", "output": [ "finding" ] }, { "id": "task1163-3d2b4c2c1ab74ca8b228334d23019ebd", "input": "The envelope glycoprotein ( Env ) of the human immunodeficiency virus type 1 ( HIV-1 ) includes the gp120 surface subunit and the gp41 transmembrane subunit.", "output": [ "finding" ] }, { "id": "task1163-5b9640a2a41c4ed6a8aa466770fc2b67", "input": "we detect that knocking down GLTSCR2 by shRNAs results in significant suppression of viral replication in mammalian and chicken cells.", "output": [ "finding" ] }, { "id": "task1163-4a3fcbbe70ad4bb1981d6bdeed6590b1", "input": "a replication model for severe acute respiratory syndrome ( SARS ) infections ( Subbarao , K.transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus ( SARS-CoV ) in the respiratory tract of mice.", "output": [ "purpose" ] }, { "id": "task1163-73f7b724709d4e21a8737d0c4e2bb777", "input": "An additional palmitoylation site was observed in CK/SWE/082066 / 2010 a QX-like strain.", "output": [ "finding" ] }, { "id": "task1163-4635eb15993749e1a57241147a777790", "input": "Group II : mycetoma patients ( n = 70 patients ; median age 25 ( range 13 to 70 60 years ) ).", "output": [ "method" ] }, { "id": "task1163-9edae544f80443d894cc18273f24eeae", "input": "Then , the recombinant fragment in pMD18-T was subcloned into corresponding sites of prokaryotic expression vector pGEX-6P-1 after digestion with EcoRI and XhoI to construct a recombinant fusion expression vector pGEX-6P-M.", "output": [ "method" ] }, { "id": "task1163-6eca21fc06114ae9945730fe3b8818d9", "input": "and its prevalence is largely unknown except cases of local outbreaks.", "output": [ "background" ] }, { "id": "task1163-57afabe0385b4444a107847bf4bfc2dd", "input": "Sequence analyses were performed to detect any recombination event among IBVs.", "output": [ "method" ] }, { "id": "task1163-f64d3f3ccc2b4185b888f7e7435ca867", "input": "To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units ( PICU ) of 16 centers in Turkey.", "output": [ "purpose" ] }, { "id": "task1163-e8ff910f1a8f4e9a814442745e0e69cc", "input": "Moreover , the present study focused on infectious diseases.", "output": [ "background" ] }, { "id": "task1163-2bf07cd83b0f4fedafb6ed24d265c529", "input": "A review of some methods for analysis of space-time disease surveillance data is presented.", "output": [ "purpose" ] }, { "id": "task1163-9cbb9f2156ca4523ae57ff8ef19c72c4", "input": "as indicated by the possibility to correctly assign up to two-thirds of viruses to their exact class based on the G-quadruplex classification.", "output": [ "finding" ] }, { "id": "task1163-c7fa5be474b641a59904a22597728614", "input": "dence time at the cell surface.", "output": [ "background" ] }, { "id": "task1163-34b5e788333c4d6fb9b1e5544dc88d63", "input": "We determined that sulfated glycans in agar inhibited plaque formation by wildtype CVB3 but not by N63Y mutant CVB3.", "output": [ "finding" ] }, { "id": "task1163-6ab45aea371b490488dbbdb2e6f06c19", "input": "The most productive search term was intensive care.", "output": [ "finding" ] }, { "id": "task1163-1ea30f5a91574fcba13b2e1cb3ec307a", "input": "thus saving critical time for 37 disease control.", "output": [ "purpose" ] }, { "id": "task1163-fe2b354a54974f3a86acbff686d89d3d", "input": "Implications for the mitigation of the swine-origin infl uenza A H1N1 pandemic are also discussed.", "output": [ "purpose" ] }, { "id": "task1163-b5d5b38465944c45b8dc9138cb81d283", "input": "This study reports on the simultaneous administration of live NDV or aMPV subtype B vaccines alongside two live IBV ( Massachusetts-H120 and 793B-CR88 ) vaccines in day-old maternal-antibody positive commercial broiler chicks.", "output": [ "purpose" ] }, { "id": "task1163-1afe90ba61f24921988cd794aff36052", "input": "nearly half were written in Mandarin.", "output": [ "method" ] }, { "id": "task1163-d5b146236d6645c2981434efa82fcf94", "input": "We used the SARS-CoV apo X-ray structure to develop a model of the NL63-PLP2 catalytic site.", "output": [ "method" ] }, { "id": "task1163-4bbbc2b80dd743d3868122fdc03ec3bb", "input": "Here we ask whether there are general properties that make a contact network intrinsically vulnerable to epidemics ( that is , regardless of specific epidemiological parameters ).", "output": [ "purpose" ] }, { "id": "task1163-e8f557a233e947eb9e09f597eb0528af", "input": "The surveillance and prevention of pathogenic microbiological contamination are the most important tasks of biosafety management in the lab.", "output": [ "background" ] }, { "id": "task1163-1adf3930ea9148728705122f07a07b34", "input": "can combine with small numbers of intermediate steps to create coherent oscillation.", "output": [ "finding" ] }, { "id": "task1163-e511dc7903ca4e20887a036af9c5c743", "input": "Altogether , these results reveal heparan sulfate as a new attachment receptor for henipaviruses and as a potential therapeutic target for the development of novel approaches against these highly lethal infections.", "output": [ "finding" ] }, { "id": "task1163-48dc9ffb9e3c4f7e9a22aa0bbee9ea37", "input": "Here , we compare substrate specificities of the papain-like protease ( PLpro ) from the recently emerged Middle Eastern Respiratory Syndrome ( MERS ) hCoV to the related protease from SARS , SARS PLpro.", "output": [ "purpose" ] }, { "id": "task1163-4e2fbaaa662745bfbebdaf84c1765434", "input": "threatening restoration efforts of this species in North America.", "output": [ "background" ] }, { "id": "task1163-311c9627c23042e2ab43861037bc53a7", "input": "aimed at a revision of the Coronaviridae taxonomy.", "output": [ "purpose" ] }, { "id": "task1163-da025037be2d40cdb8420ebbf80a5e1c", "input": "Objective : To investigate racial differences in time to melanoma treatment.", "output": [ "purpose" ] }, { "id": "task1163-eaf57577317f4679961570a82b47f1b5", "input": "The objective of this study was to investigate the effect of equine arteritis virus ( EAV ) on type I interferon ( IFN ) production.", "output": [ "purpose" ] }, { "id": "task1163-946a27cf94d2454f8b856462eb4d1cf1", "input": "and the G-quadruplex field has been growing dramatically over the last decade.", "output": [ "background" ] }, { "id": "task1163-7bd378a46bd14f4c957ada6386f81b96", "input": "All of the hamsters infected with the APMVs produced serotype-specific HI or neutralizing antibodies , confirming virus replication.", "output": [ "finding" ] }, { "id": "task1163-ef34586a37b246b09b5aea9ff94ae38f", "input": "Maximum likelihood analysis was conducted by using Molecular Evolutionary Genetics Analysis 6.06 ( 7 ).", "output": [ "method" ] }, { "id": "task1163-c37f590b595a4e8dbce1c9e5bd7ca12b", "input": "provided counseling services to residents concerned about radiation health risks or mental health issues.", "output": [ "background" ] }, { "id": "task1163-c9655b8107194b67b0291461abaf9896", "input": "This study aims to investigate the utility of next generation sequencing ( NGS ) method to detect possible contamination in the microbiology laboratory.", "output": [ "purpose" ] }, { "id": "task1163-5f3a179e73814a5697582ffe8fe90b18", "input": "leading to the generation of MEDI8852.", "output": [ "method" ] }, { "id": "task1163-4fa1b93657a64628a70abe74fbe9b121", "input": "and Dengue virus serotype 2 ( DENV-2 ).", "output": [ "method" ] }, { "id": "task1163-89d8f1c272f745ac89f8ef0a7b28146e", "input": "as well as the conditions for their handling and use in downstream processes.", "output": [ "purpose" ] }, { "id": "task1163-15f220cab6fd436dbc076a553088b697", "input": "This two-part article will review the molecular basis of each technology and how the technology has been applied to clinical diagnostic systems.", "output": [ "purpose" ] }, { "id": "task1163-aa9f0b4102364228b23fae82a4ceb604", "input": "Despite the clinical relevance , dengue virus ( DENV ) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses.", "output": [ "background" ] }, { "id": "task1163-4ea26a99628042559d0b886fce1c6b15", "input": "Understanding the mechanisms that regulate innate immune responses to IAV and other viruses is of key importance to develop novel therapeutic strategies.", "output": [ "background" ] }, { "id": "task1163-4782f8b9fdde423eb5b9370b3ad2ee45", "input": "he or she has a collection of favorite locations.", "output": [ "method" ] }, { "id": "task1163-171271d85edd47d7a2bc510b93325cdc", "input": "Collectively , these results have implications for the refolding of pneumovirus and paramyxovirus fusion proteins and should inform development of prefusion-stabilized RSV F vaccine candidates.", "output": [ "finding" ] }, { "id": "task1163-4701fb04f6264f519557dcc950c01d60", "input": "Comparative analysis of the lipid compositions of CyHV-3 and CCB membrane fractions revealed strong similarities between the lipid composition of the CyHV-3 and CCB lipid rafts.", "output": [ "finding" ] }, { "id": "task1163-191a1783268c460696bbe54797380e90", "input": "a general strategy was designed to obtain polyclonal and particularly monoclonal antibodies specific of the 6HB motif of the Pneumovirinae fusion protein.", "output": [ "method" ] }, { "id": "task1163-a8f5c74608e344a2ae7fd787623f6e74", "input": "China , which strongly suggests that the reported cases constitute only a small fraction of the actual number of infected individuals in China 2.", "output": [ "finding" ] }, { "id": "task1163-b241ef99a61f469594ce71a467843bb9", "input": "He was then transferred to the University of Chicago Medicine MICU.", "output": [ "background" ] }, { "id": "task1163-d84afa9f0e704a11a4871b22fe7bb8cc", "input": "considering as principal vector Aedes aegypti.", "output": [ "method" ] }, { "id": "task1163-93cae9c08702402187d0c1bd77b7574e", "input": "not cyclophilin B. Cyclophilin inhibitors abolish this interaction.", "output": [ "purpose" ] }, { "id": "task1163-961f355bee9e4c929bb5044540281eb1", "input": "underscoring its potential key role in the development of unbiased NGS-based clinical assays in infectious diseases that demand rapid turnaround times.", "output": [ "finding" ] }, { "id": "task1163-b12420872a504efb9401cdc97a01a85f", "input": "This study first describes the dynamics of antibody response in infected ducks and identifies frequently recognized antigens that may serve as diagnostic markers of infection by T. regenti.", "output": [ "purpose" ] }, { "id": "task1163-324a461c8abe4fd3840f06e99dccfbdd", "input": "NK cells can directly sense and kill MCMV-infected cells.", "output": [ "background" ] }, { "id": "task1163-8575f553366e49189b4f5ab01ff1e5ca", "input": "African lineages of MERS-CoV do not establish themselves in Saudi Arabia.", "output": [ "finding" ] }, { "id": "task1163-c55e9db0b7784ed1adb016f1ff7335d3", "input": "the SARS outbreak , as well as the ever-present threat of global bioterrorism.", "output": [ "background" ] }, { "id": "task1163-6f9a9a8581f64ed69e2b8113de3a13fb", "input": "Inactivation of YopH activity would lead to the loss of bacterial pathogenicity.", "output": [ "background" ] }, { "id": "task1163-575556607626420e96e6556e8145eca5", "input": "Three class I genes ( FLAI-H , I-K , I-E ) may encode functional classical class I antigens based on deduced amino acid sequence and promoter structure.", "output": [ "background" ] }, { "id": "task1163-4b217278aea841c7b6ad85b9a9611e46", "input": "Two types of silver nanowires were 60 nm and 400 nm in diameter , respectively.", "output": [ "method" ] }, { "id": "task1163-f28eb3ebc2fd4f599dd538dd9c4b9775", "input": "Methods : ITIS was used to measure cutaneous temperature in 1275 airline travellers who had agreed to tympanic temperature measurement and respiratory sampling.", "output": [ "method" ] }, { "id": "task1163-6c4b16deb2ee4464aa672e38c4bd07a7", "input": "there is no uniform inclusion of respiratory viral infection management in the clinical hematology routine.", "output": [ "background" ] }, { "id": "task1163-794e71f4c66341ad8ac4275a62587d7f", "input": "but minimal signs of haemorrhage in the lesion.", "output": [ "finding" ] }, { "id": "task1163-b2122d5a0a8c4abc8dc318c411245b85", "input": "The latter process is most likely to occur in the Golgi or post-Golgi compartment.", "output": [ "finding" ] }, { "id": "task1163-7081943c5f1e48ad9b842c39e1ae3311", "input": "pathology , histopathology , virus replication , and seroconversion.", "output": [ "method" ] }, { "id": "task1163-e17686054f3a43708553f6aa23af3142", "input": "Error bars show 95 % confidence interval.", "output": [ "method" ] }, { "id": "task1163-df535fa7f7564a66b227558fb69712db", "input": "are deposited during embryogenesis in bone marrow and other organs as a backup population for adult tissue committed stem cells ( TCSCs ) and are involved in several processes related to tissue or organ rejuvenation , aging , and cancerogenesis.", "output": [ "purpose" ] }, { "id": "task1163-ce6f817920184a32b37c91dccbdac09d", "input": "Study Design and Methods-The distribution of blood groups was investigated within a cohort of 374 WNV + blood donors including 244 asymptomatic ( AS ) and 130 symptomatic ( S ) WNV + blood donors.", "output": [ "method" ] }, { "id": "task1163-043a10a18de94df4a9cdac89175776ab", "input": "In this article , we identify key concepts and components associated with this emerging research theme.", "output": [ "purpose" ] }, { "id": "task1163-cb8a24a1461e4a59aec32f2d700ca3be", "input": "Toward this goal , we performed two-dimensional gel electrophoresis fractionation coupled to mass spectrometry identification approaches to perform a comprehensive proteomic analysis of purified IBV particles.", "output": [ "method" ] }, { "id": "task1163-fab6cc4cee044c6aab3c5603b9c4c439", "input": "We propose that highly efficient ؊ 1 PRF in TMEV provides a mechanism to escape the confines of equimolar expression normally inherent in the single-polyprotein expression strategy of picornaviruses.", "output": [ "finding" ] }, { "id": "task1163-2695ca08898f422ba02b3a4d8000085e", "input": "Diarrheic calves had higher odds of BCoV presence than healthy calves ( OR : 2.16 , 95 % CI : 1.26 to 3.83 , P = 0.004 ).", "output": [ "finding" ] }, { "id": "task1163-8349c90ffde64d4bba9f3aed453fc9b1", "input": "and 78 were enrolled in this study from August 2003 to March 2018.", "output": [ "method" ] }, { "id": "task1163-dacf368fbd8b4987b04b30841bcd136a", "input": "the total seropositive rate for IgM and IgG was 50.0 % and 92.1 % , respectively.", "output": [ "finding" ] }, { "id": "task1163-f1940f8f3f0643cfbad2bfd224319d3a", "input": "ie , whether this occurs in the healthy CNS or only during inflammatory conditions and what the related cytokine microenvironment is comprised of.", "output": [ "background" ] }, { "id": "task1163-240cd2345aa045519613c2c7b92b55b5", "input": "whereas the inhibitory activity towards S-adenosyl-L-homocysteine ( SAH ) hydrolase will be retained.", "output": [ "method" ] }, { "id": "task1163-b7fabc3a7db04c9bb9bbaab8d5865461", "input": "In Sulfolobus solfataricus DnaG and Rrp4 but not Csl4 show preference for poly ( rA ).", "output": [ "background" ] }, { "id": "task1163-112566486e634e56ad213d689ed02259", "input": "was used for lethal challenge in animal experiments.", "output": [ "method" ] }, { "id": "task1163-65dac333b2844c36a21f0e02bfea143c", "input": "Furthermore , we determined the complete genomic sequence of BP-caKII to understand the genetic changes related to cold adaptation.", "output": [ "method" ] }, { "id": "task1163-79096ff47e864802902b84647284ca39", "input": "and to determine the clinical significance of respiratory pathogens in TB patients.", "output": [ "purpose" ] }, { "id": "task1163-4e722baba2ff4f06b0ea90f802259a37", "input": "( 2 ) mos t component s of th e immunologi c syste m i n huma n mil k ar e produce d throughou t lactation an d durin g gradua l weaning ; ( 3 ) th e factor s ar e usuall y commo n to othe r mucosa l sites ; ( 4 ) the y ar e adapte d t o resis t digestio n i n th e gastrointestinal trac t of th e recipien t infant ; ( 5 ) they protec t b y noninflammatory mechanisms ; an d ( 6 ) th e agent s ac t synergisticall y wit h eac h othe r or with defense agent s produced b y the recipient.", "output": [ "finding" ] }, { "id": "task1163-e36984a74b4040c1a54ba94710246a65", "input": "we also identified ARI episodes among other children < 5 years old in the same household.", "output": [ "method" ] }, { "id": "task1163-f61dbadc599d4c6da49743b7509fe5bd", "input": "but als o supplie s a hos t o f defens e factor s fo r th e protectio n o f th e recipient and/o r th e mammar y gland.", "output": [ "background" ] }, { "id": "task1163-3de34d05202f4bb8a6a44c00b51f85b4", "input": "Interpretation : We found that in most scenarios contact tracing and case isolation alone is unlikely to control a new outbreak of 2019-nCov within three months.", "output": [ "finding" ] }, { "id": "task1163-08511d97c9f7407cbcf4b044c1657468", "input": "In the simulations we account for uncertainty in the number of secondary cases in the absence of air traveller targeted interventions and the arrival times of infected cases and also present sensitivity analyses on arrival rates of infected travellers and the effectiveness of traveller sensitisation.", "output": [ "method" ] }, { "id": "task1163-1bdee397cafc40098c2bce1d1f3812e0", "input": "Respiratory viruses of human origin infect wild apes across Africa , sometimes lethally.", "output": [ "background" ] }, { "id": "task1163-9d869be3175048c2b38df159e12a6c15", "input": "We conducted a simulation study to compare clinical case finding with syndromic surveillance for detection of an outbreak of inhalational anthrax.", "output": [ "method" ] }, { "id": "task1163-1681f3be638548d19a5c34ec7625ba05", "input": "The review highlights knowledge gaps in these research areas.", "output": [ "purpose" ] }, { "id": "task1163-27d38976283e4c7d903ffb633a4edb56", "input": "Here , we present The Genome Detective Coronavirus Typing Tool that can accurately identify novel coronavirus ( 2019-nCoV ) sequences isolated in China and around the world.", "output": [ "purpose" ] }, { "id": "task1163-797bf149b5a940038a30473c26025298", "input": "In this study , we demonstrate that treatment of Vero E6 cells with interleukin-4 ( IL-4 ) decreased the susceptibility of these cells to SARS-CoV infection.", "output": [ "purpose" ] }, { "id": "task1163-2742099abb4846a390c1a0c57ea2e851", "input": "Finally , the projected epitopes were ranked based on their scores and binding modes through using Moe 2007 program.", "output": [ "method" ] }, { "id": "task1163-c4b5d2d74b8f4fc99e94742e81d0d65f", "input": "This study aims to use bibliometric analysis to estimate the global activity within this rapidly developing field and to identify particular areas of focus that are of current relevance to the MGBA during the last decade ( 2009 ) ( 2010 ) ( 2011 ) ( 2012 ) ( 2013 ) ( 2014 ) ( 2015 ) ( 2016 ) ( 2017 ) ( 2018 ).", "output": [ "purpose" ] }, { "id": "task1163-3b8b4d08100f498a8309f0b2d3f4e677", "input": "Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents.", "output": [ "background" ] }, { "id": "task1163-f2659e06d4734cd4b9a38b7d53c5fd25", "input": "activation , and maintenance as well as characteristics of B cell responses and antibody levels during ageing in relation to other cells and factors that are interwoven with B cell biological processes.", "output": [ "purpose" ] }, { "id": "task1163-f232fc6831da499490d74654accd1d1c", "input": "and are likely to fail because of the enormous number of unsampled viruses that could conceivably emerge in humans.", "output": [ "purpose" ] }, { "id": "task1163-cd0b2595f9f044198e20632fd6ca84b5", "input": "Information about critically ill patients with SARS-CoV-2 infection is scarce.", "output": [ "background" ] }, { "id": "task1163-965888ffbe544df690bc6a79626ee053", "input": "inactivate , and inject , '' fi rst invoked by Louis Pasteur.", "output": [ "background" ] }, { "id": "task1163-2508ce2295a845899537104ed3c87389", "input": "This was confirmed by Western blot analysis.", "output": [ "method" ] }, { "id": "task1163-f0bd5b7c1f624a068fd5a2ecfb28a000", "input": "which provided a new insight to the pathogenic mechanism of SARS-CoV-2.", "output": [ "finding" ] }, { "id": "task1163-73c50520afaf4a189bc2d70129f78063", "input": "and suggest that under certain conditions inhibition of A20 might be of interest in the management of IAV infections.", "output": [ "finding" ] }, { "id": "task1163-49cc6abfb5e64b448bd1ba569c8bca2b", "input": "while control group was supplied with an identical meal without virus.", "output": [ "method" ] }, { "id": "task1163-baf3cdc79d464a3781afdf9801dfe94e", "input": "Still disappointing results from a seductive idea • Mucosal surfaces of the respiratory tract represent a major portal of entry for most human viruses and a critical component of the mammalian immunologic repertoire.", "output": [ "background" ] }, { "id": "task1163-de31f2f4553f430eb975d5b7ac6e7d75", "input": "the cross antiviral activity of a neutralizing antibody against enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) was investigated in vitro.", "output": [ "background" ] }, { "id": "task1163-e6e73c4029894d9aadad2102daa0a299", "input": "We investigated two patients who developed acute respiratory syndromes after independent contact history with this market.", "output": [ "purpose" ] }, { "id": "task1163-935155c863e147508fed74878f5faa0a", "input": "thereby promoting viral dissemination within the host.", "output": [ "background" ] }, { "id": "task1163-f173fe8c99234537a2582758fd4c9d0f", "input": "Canine distemper virus ( CDV ) invades the nervous system and replicates in neurons and glial cell of the white matter during a period of severe viral induced immunosuppression.", "output": [ "background" ] }, { "id": "task1163-09549d85ecfc44348e4dbfde093ebdc8", "input": "with the assumption that if the same screening effort used in other cities applied in Wuhan.", "output": [ "method" ] }, { "id": "task1163-e3ea69adf53348b193f4ba09bee6ef76", "input": "which facilitates viral attachment , entry and membrane fusion is heavily glycosylated and plays a critical role in the elicitation of the host immune response.", "output": [ "background" ] }, { "id": "task1163-7deed06c29c94cf4a939fe51c1247868", "input": "Additionally , the expert decision analysis process was modified to quantitatively resort types ; these assessments involve multiple criteria and interdependent features.", "output": [ "method" ] }, { "id": "task1163-f0c38cd1f6c0411e8326e61fee7546ae", "input": "Participants : 63 557 subjects aged 0-19 years with fall injury record were included in the analysis.", "output": [ "method" ] }, { "id": "task1163-032a7eed9bcc4525950c9998743a5705", "input": "The population genetics of the family Partitiviridae was studied within the European race of the conifer pathogen Gremmeniella abietina.", "output": [ "purpose" ] }, { "id": "task1163-0015e7fa70ba4caa8edeb692da7cb30f", "input": "Khuzestan Province , Iran by performing fecal examination and autopsy.", "output": [ "method" ] }, { "id": "task1163-b9f01918e65d49b689052f6bf06eea86", "input": "lo que evidencia que aproximadamente la mitad de los terneros se infectaron con BCoV.", "output": [ "finding" ] }, { "id": "task1163-ad406f1113344c09a9b9496b27ece356", "input": "The epithelia exposed to 95 % oxygen and 5 % carbon dioxide were pseudostratified.", "output": [ "finding" ] }, { "id": "task1163-dd69d8a8e74e40eaa32a5c1e972c32a6", "input": "By contrast , the pyrophosphate analogue foscarnet blocks viral genome replication by directly inhibiting HSV DNA polymerase activity ( 4 ).", "output": [ "background" ] }, { "id": "task1163-6d52122b8797409688bc9d2e0d6a2c87", "input": "mientras que los animales con títulos bajos de IgG1 ( < 1.024 ) estuvieron predispuestos a la infección.", "output": [ "finding" ] }, { "id": "task1163-588ea49262de415595303bd0ac13bb02", "input": "All the six AMI patients were aged > 60 years ; five of them had two or more underlying comorbidities ( hypertension , diabetes , cardiovascular diseases , and chronic obstructive pulmonary disease ).", "output": [ "finding" ] }, { "id": "task1163-3c863cfa2b3e4abba50b8f145367726b", "input": "clinical and risk factor data were collected at enrollment in children aged < 15 years presenting to an emergency department with an ARI and where cough was a symptom.", "output": [ "method" ] }, { "id": "task1163-7c658903f99048498189ebdcb221d71d", "input": "We used the bivariate random effects model for quantitative meta-analysis of the results.", "output": [ "method" ] }, { "id": "task1163-0962dec2c8834f65b624fcaaeddf0974", "input": "In the present study , the influence of the administration of rFeIFN on blood markers of inflammation ( a-globulins , a 1acid glycoprotein ) and immune system activation ( g-globulins , IgG , IgM , specific anti-feline parvovirus IgG or IgM ) was evaluated in a cattery developing an outbreak of feline panleukopenia due to feline parvovirus ( FPV ) infection few days after initial administration of rFeIFN.", "output": [ "purpose" ] }, { "id": "task1163-488a6e746d0044998771e35f35ad8a77", "input": "7.75 log 10 plaque-forming units ( PFU ) / mL.", "output": [ "method" ] }, { "id": "task1163-49a73a16f5844fdba41623326c5e721a", "input": "Virus entry and virus-induced syncytium formation using the CAT-1 receptor are mediated by a small number of critical amino acid residues in receptor and virus Env.", "output": [ "finding" ] }, { "id": "task1163-3e157c70b07345dba15e2ae76e1198bf", "input": "Here , this system was compared with an autotransporter protein surface display system.", "output": [ "method" ] }, { "id": "task1163-78d84fa9a7c24f1586653ad481e2d38b", "input": "it was significantly lower ( p < 0.01 ) for test positive herds.", "output": [ "finding" ] }, { "id": "task1163-91fbf54271a54c19a4b201e4235d6928", "input": "• Factors likely to induce mucosal antibody and cell-mediated immune responses include oral or respiratory routes of immunization and active ( effectively replicating ) vaccine agents.", "output": [ "background" ] }, { "id": "task1163-bd57a62f63d046999284b4d9576e888f", "input": "To date , however , the utilization of this sequence data to rapidly produce relevant experimental results or actionable treatments is lagging in spite of obtained sequence data.", "output": [ "background" ] }, { "id": "task1163-9dda3991a9e94ccdb5d5d13934ef6fe5", "input": "Over 20,000 people have received the vaccine in clinical trials ; the vaccine has proven to be safe and well tolerated.", "output": [ "method" ] }, { "id": "task1163-891c9661402a416b8bec2926ff775bec", "input": "although protein and RNA biochips are also briefly considered.", "output": [ "purpose" ] }, { "id": "task1163-8022cdd7da094afc90614fd4117b31c8", "input": "including Centor score , were analysed in relation to pathogens.", "output": [ "method" ] }, { "id": "task1163-f67f35d4bcc04167b3bc98e72dc176c8", "input": "IL-6 , IL-8 , IL-10 and tumor necrosis factor ( TNF ) in bronchoalveolar lavage fluid ( BALF ) as potential biomarkers for pulmonary infection in lung-transplanted patients.", "output": [ "purpose" ] }, { "id": "task1163-fd91ace241794a17aff130b295eef48f", "input": "a potentially lethal disease , feline infectious peritonitis ( FIP ) occurs.", "output": [ "background" ] }, { "id": "task1163-a777028169054af495dc0353e6101416", "input": "quality control measures , and assay parameters used to identify respiratory viruses.", "output": [ "background" ] }, { "id": "task1163-b389b825bc4b4140b5e216eb54123709", "input": "Here we highlight three main efforts that have progressed the implementation of One Health in Kenya.", "output": [ "purpose" ] }, { "id": "task1163-ce565513343c4c47aba28a69231272d4", "input": "Moreover , EV71 infection also increased the release of IFN-β and IL-12 p40.", "output": [ "finding" ] }, { "id": "task1163-c708bccd8eae4b398f88e4c233de5846", "input": "management methods , and clinical outcomes.", "output": [ "method" ] }, { "id": "task1163-57c211d6e8b54929b85c4d84cff8dd5b", "input": "Cairo University over one year included children presenting with symptoms of acute respiratory infection.", "output": [ "method" ] }, { "id": "task1163-6ee63a71c26b46f283a37f6f8f6087a4", "input": "Objective : The goal is to present a ranking algorithm able to select the best documents for clinicians considering aspects related to the relevance and the quality of said documents.", "output": [ "purpose" ] }, { "id": "task1163-7957dd2402df477394132c6de016816e", "input": "For adaptive immunity , viral antigens can be processed in autophagosomes by acidic proteases before major histocompatibility complex ( MHC ) class II presentation.", "output": [ "background" ] }, { "id": "task1163-083971f0cf6a4f37809bdf9808412796", "input": "and applies them to the choice of suitable RNA-dependent RNA polymerase ( RdRP ) target-template pairs within human-infective RNA virus genera.", "output": [ "purpose" ] }, { "id": "task1163-b8bdc4d3d20b4af8b525d4ad58e52b22", "input": "Sixty-five outbreaks contained complete data on both onset dates and ward position.", "output": [ "finding" ] }, { "id": "task1163-ece69d9a4d574f3bb39f5b87e0b71673", "input": "In this paper , we demonstrate the uses of some simple mathematical models for the study of disease dynamics in a pandemic situation with a focus on influenza.", "output": [ "purpose" ] }, { "id": "task1163-f73fbc50797f493b8f1f3c56c60e7bc0", "input": "a positive reaction could be obtained when an infected gill tissue sample that contained 430 viral copies/μg was diluted up to five orders of magnitude.", "output": [ "finding" ] }, { "id": "task1163-69c245b49a6a45a38cdf8df6a0bf665e", "input": "Dendritic cells ( DC ) are critical to an integrated immune response and serve as the key link between the innate and adaptive arms of the immune system.", "output": [ "background" ] }, { "id": "task1163-7a03ba24b4ef46079d577c25aa41c118", "input": "The cat was palliatively managed using rutin and a low-fat diet.", "output": [ "method" ] }, { "id": "task1163-fea98d0e2a3844ea97b6f8ec30f3f524", "input": "This interaction was mediated by the N-terminal acidic domain of nsp3.", "output": [ "finding" ] }, { "id": "task1163-60a511a7dda145a3be31528978541ac5", "input": "receptor usage , cellular source and biological activities.", "output": [ "background" ] }, { "id": "task1163-2744943f4248421fa5cc1a4a5a673e60", "input": "Conclusion : IFN-γ +874 A allele was shown to be a risk factor in SARS susceptibility.", "output": [ "finding" ] }, { "id": "task1163-be92568bb18c4f03b5a1c270732c8167", "input": "The resulting tetra-mutant G11A/L141T/R298A / Q299A is indeed enzymatically active as a monomer.", "output": [ "finding" ] }, { "id": "task1163-14cae134f7634739845cd918a66b316c", "input": "Results from the present study provide further support to the classification of partetraviruses as a separate genus in Parvovirinae.", "output": [ "finding" ] }, { "id": "task1163-062bf550230f44988f54b038484b0a9b", "input": "respectively , were predicted to be cleaved into 16 subunits by two viral proteinases.", "output": [ "method" ] }, { "id": "task1163-6680f6dcfafb44518338dee4f09d523b", "input": "Why organisms have different mutation rates is a longstanding question in evolutionary biology.", "output": [ "background" ] }, { "id": "task1163-bcfeaab2beb94f99966db2e3fd1308eb", "input": "This phenomenon can be well explained by a mean-field approximation.", "output": [ "finding" ] }, { "id": "task1163-c0f1d76c04734697bfe050ca94dcf7a6", "input": "Ramsay Hunt syndrome with laryngitis due to varicella zoster virus was suspected and the patient was started on acyclovir and steroid therapy.", "output": [ "method" ] }, { "id": "task1163-f10af183d1864f458b253a622fb8fe3d", "input": "We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia.", "output": [ "purpose" ] }, { "id": "task1163-556dde445d4343e9a3d1e807606f8c68", "input": "and 35 d following diagnosis.", "output": [ "method" ] }, { "id": "task1163-4cab7b9b35944d34b35291b5388de7a2", "input": "Cotton ( Gossypium spp. ) is the main source of renewable textile fibers and is also grown to produce vegetable oil and high protein meals for humans and livestock ( 23 ).", "output": [ "background" ] }, { "id": "task1163-ca4a4032886747fd9f54e0b4f6db5922", "input": "IEM methods assist with the detection ofsmall viruses or viruses present in low numbers while PAG offers increased sensitivity over direct EM and IEM.", "output": [ "method" ] }, { "id": "task1163-e9826b90d7014456b68849028deba358", "input": "Here , we report an in-flight transmission cluster of COVID-19 and describe the clinical characteristics of these patients.", "output": [ "purpose" ] }, { "id": "task1163-bf8e7e08328e404aa9c5e7da125aeb22", "input": "The hemagglutinin-esterase ( HE ) gene of Breda virus serotype 2 ( BRV-2 ) has been identified and the nucleotide sequence for BRV serotype 1 ( BRV-1 ) genome which contains the open reading frames for the viral structural proteins has been reported revealing the presence of a 1.25 kb gene whose nucleotide sequence is identical to that of the BRV-2 HE gene.", "output": [ "background" ] }, { "id": "task1163-32b94dd646fb49a693f97cae0590eb7d", "input": "including the muscle , the retina and the brain.", "output": [ "purpose" ] }, { "id": "task1163-7b9402282b924f4a904225ed36ff2d84", "input": "We assumed that syndromic screening would reduce the number of infected arrivals and that traveller sensitisation reduce the average number of secondary cases.", "output": [ "method" ] }, { "id": "task1163-c14837db3e7c444989d27dd039eb7bf1", "input": "This review will cover the most recent knowledge regarding viral and non-infectious of pregnancy losses in the dog and cat.", "output": [ "purpose" ] }, { "id": "task1163-f4bf557cef014347b592acbf47453a85", "input": "associated with a major epidemiological transition that is accompanied by an unexpected rise of new and emerging infectious diseases.", "output": [ "background" ] }, { "id": "task1163-7659367ebbb14972aef0facea5fb77f4", "input": "Furthermore , sIFITM3 blocked FMDV infection at early steps in the virus life cycle by disrupting viral attachment to the host cell surface.", "output": [ "finding" ] }, { "id": "task1163-caac0d48188543afa3992bbe589de093", "input": "multiple sclerosis ( MS ).", "output": [ "purpose" ] }, { "id": "task1163-ab63b3b1e2e542e8b85a5c61d6b6414f", "input": "A culture specimen from tracheal aspirates grew methicillin-susceptible S. aureus.", "output": [ "finding" ] }, { "id": "task1163-9e805fe772084ff380d9c9daaa67e742", "input": "Heterologous production of brazzein is complicated by the fact that the protein contains four disulfide bridges and requires a specific N-terminal sequence.", "output": [ "background" ] }, { "id": "task1163-950125b6b50f48e58707576c807c92d4", "input": "Bangladesh has experienced a variety of diseases caused by natural dissemination of an array of pathogenic microorganisms into the environment.", "output": [ "background" ] }, { "id": "task1163-e7452d88289240c7903a7de81cbe9231", "input": "The authors present a mathematical and ethical justification for a palliative care surge plan and outline some of the key elements that should be included in such a plan.", "output": [ "purpose" ] }, { "id": "task1163-a6e4ad69e01d485999010055a44b25d3", "input": "Ghanaian domestic livestock are not likely intermediate hosts of HCoV-NL63-related coronaviruses.", "output": [ "finding" ] }, { "id": "task1163-e0c0918149384253b2d8345d347a1472", "input": "although it is involved in PDCoV infection.", "output": [ "finding" ] }, { "id": "task1163-92f49db320654b6da6c5c325d2df9ab7", "input": "mRNA for tumor necrosis factor a and interleukin lfl was detectable.", "output": [ "finding" ] }, { "id": "task1163-4eda8b7b7ce74f4fb93b547f62d13b4c", "input": "CRTC1 interacts with CREB and they are mutually required for the recruitment to the preS2/S promoter on cccDNA and for the activation of HBV transcription.", "output": [ "finding" ] }, { "id": "task1163-d04a5df2faf14b338aeeae587ddca786", "input": "antiviral therapy is an important complement that can not be substituted.", "output": [ "background" ] }, { "id": "task1163-f8083697ea7f46c5a19bf06e2f9f6a41", "input": "Mainly positive-strand RNAs were synthesized and protein synthesis was not required for RTC activity in vitro.", "output": [ "method" ] }, { "id": "task1163-241f8d5a5fbc4365a49c719868367de6", "input": "and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures.", "output": [ "method" ] }, { "id": "task1163-08e5838bc4d4481686ac8d225024d547", "input": "the two main groups of these viruses in Australia.", "output": [ "method" ] }, { "id": "task1163-9c41a1ed037645d3bee0d8867ee504d4", "input": "These patients are subject to a separate AGIHO guideline ( 1 ).", "output": [ "finding" ] }, { "id": "task1163-f8e78526524c4cc69783819b01e6c42a", "input": "The primary objective of this panel discussion was to seek input on the following 3 questions from the speakers at the workshop.", "output": [ "purpose" ] }, { "id": "task1163-e9ad76f03c4d48289d4a1395aa63d4e7", "input": "• Intracerebral haemorrhage is an uncommon presentation of ITP.", "output": [ "finding" ] }, { "id": "task1163-117625b70f074ec3b8d2d22703c997c6", "input": "patients with a confirmed diagnosis of SARS had significantly different clinical features and timing of mortality from those of the control group.", "output": [ "finding" ] }, { "id": "task1163-b63424a3757c4199a8d4cb930dcbbc4b", "input": "Furthermore , rRNA-derived transcripts with heteropolymeric tails were degraded faster by the exosome than their non-tailed variants.", "output": [ "finding" ] }, { "id": "task1163-bbba78fe3d8c4475b57f024329301cd4", "input": "The HN glycoprotein has a single sequence near the amino terminus that functions as both a signal-sequence and a transmembrane-spanning segment.", "output": [ "background" ] }, { "id": "task1163-fc75a59812914d7a94962c471e29af3d", "input": "and imported into Microsoft ® Excel.", "output": [ "method" ] }, { "id": "task1163-5b2aa9969134465690291256edfec710", "input": "This article details some of the infectious disease pharmacogenomics to the developments in this area.", "output": [ "purpose" ] }, { "id": "task1163-2a1e4a42e9954aacb6b215a041af02e3", "input": "and outcome for Weimaraners with hypertrophic osteodystrophy ( HOD ).", "output": [ "purpose" ] }, { "id": "task1163-c99b91ac41fe47979bb3034bb20f85e2", "input": "The antibodies reported here should assist in the characterization of the structural changes that the F protein of human metapneumovirus or respiratory syncytial virus experiences during the process of membrane fusion.", "output": [ "finding" ] }, { "id": "task1163-475f92402c164b34984842c6f9437ed3", "input": "Patients with positive results of either reverse transcriptase-polymerase chain reaction or antibody to SARS coronavirus were defined as SARS cases and others with negative results as control cases.", "output": [ "method" ] }, { "id": "task1163-e6262aeaba864db4834371708a3aaaca", "input": "The main aim of this review is to summarize the latest findings and applications in the field of pathogen detection using microsphere-based multiplex assays.", "output": [ "purpose" ] }, { "id": "task1163-992686d1db9d4f529756847a25d93385", "input": "a dose trend in events of moderate or greater severity was also noted for these solicited events.", "output": [ "finding" ] }, { "id": "task1163-94931aecf9d84ecdb5bdd5a212e92a72", "input": "and how long they should be maintained.", "output": [ "finding" ] }, { "id": "task1163-fa0dbfcf2a2340c0aefc5ffea1882c82", "input": "and keywords for subsubjects of critical care.", "output": [ "method" ] }, { "id": "task1163-12a8a254d75e44f4adcbb6850ca72a92", "input": "Second , the reovirus σ3 protein can bind dsRNA and prevent activation of the latent antiviral effector protein PKR.", "output": [ "finding" ] }, { "id": "task1163-760c65e81549486a9e8de5c026a7ae3e", "input": "however this was not statistically significant ( RR : 0.82 , CI 95 : 0.53-1.26 , p = 0.36 ).", "output": [ "finding" ] }, { "id": "task1163-41c31fe5ea554805ae7a3afb9024e9f6", "input": "potentially through breakdown of the blood-ocular barrier.", "output": [ "finding" ] }, { "id": "task1163-b12c89fdf64941139f24a6b30c254ed0", "input": "In this investigation , a panel of scorpion venom peptides and their derivatives were designed and chosen for assessment of their anti-HIV activities.", "output": [ "purpose" ] }, { "id": "task1163-820bc39e763d4010bbc0c28c51608913", "input": "Thus , understanding the pathways through which inflammatory monocytes migrate to the brain and their functional capacity within the CNS is critical to inform future therapeutic strategies.", "output": [ "purpose" ] }, { "id": "task1163-1d8c31b934c241739a81a2981eed3cf6", "input": "feline calicivirus ( FCV ) and felid herpesvirus 1 ( FeHV-1 ).", "output": [ "method" ] }, { "id": "task1163-223f68ac0715408294eb527b1e297402", "input": "Live vaccines are non-adjuvanted , and non-live vaccines are generally adjuvanted.", "output": [ "background" ] }, { "id": "task1163-4171aa2fabf749b58d7ef3bb3f92964b", "input": "identification of druggable targets and the final development of effective antiviral therapies.", "output": [ "background" ] }, { "id": "task1163-8ef73844aa7d437b9908808be3ed2664", "input": "However , information regarding such changes in animal disease is limited In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell traficking by flow cytometry.", "output": [ "background" ] }, { "id": "task1163-2fea789ea24f4761824f86d6f20d98c1", "input": "This study investigates the impacts of high-speed rail ( HSR ) on domestic air transportation in China using a new comprehensive modeling framework utilizing both demand and supply perspectives.", "output": [ "purpose" ] }, { "id": "task1163-f823795197cb434c902d2cbfaa83b2f9", "input": "Analyses of amino acids substitutions of the S protein sequences identified substitutions specific for genotype F strains circulating among European people.", "output": [ "finding" ] }, { "id": "task1163-28d9033e16f045a18a47c315c2807a55", "input": "The Protective Arm of the Renin-Angiotensin System ( RAS ).", "output": [ "finding" ] }, { "id": "task1163-fa691ed20e7b479f8d2564d1045821e9", "input": "The purpose of this form is to provide readers of your manuscript with information about your other interests that could influence how they receive and understand your work.", "output": [ "purpose" ] }, { "id": "task1163-e0aebb08c77948a5b55a0b55fee88ff0", "input": "while synchronization in G2/M inhibits viral production.", "output": [ "finding" ] }, { "id": "task1163-6b21ffddad0841f98fec8f0fac3ad989", "input": "where each associated with distinct Gag particles.", "output": [ "finding" ] }, { "id": "task1163-00ee8fb4877c4db186912912b0ea2624", "input": "A phylogenetic tree was constructed from the genome sequences.", "output": [ "method" ] }, { "id": "task1163-339b8a5f5ae5429f924e96c9b3bca357", "input": "The absence of mRNA in unstimulated cells indicates cultured macrophages were not activated until stimulated by LPS or plastic adherence.", "output": [ "finding" ] }, { "id": "task1163-2e33a6f27ca74401a56ac0eb5362d16f", "input": "Hence , a higher redundancy has been proposed in the mechanisms promoting protective immune responses against systemic infections by herpes viruses during natural infections in humans.", "output": [ "background" ] }, { "id": "task1163-5470b26aab034f4596b4dcfd24426a3b", "input": "approximately 3 s. Abdominal exam showed normal liver and spleen to palpation and was nontender.", "output": [ "finding" ] }, { "id": "task1163-ae250557c2164739adcbbfecc6ebed2c", "input": "In this review , we discuss the current understanding of the fates of flavivirus vRNA and how this is regulated at the molecular level to achieve an optimal replication within infected cells.", "output": [ "purpose" ] }, { "id": "task1163-648f5f9714c34b32ac47168d824fc79c", "input": "The use of alcohol-based hand sanitizer and soap showed a significant increase in utilized amount ( P < .0000001 ).", "output": [ "finding" ] }, { "id": "task1163-4d63a61fcb6f4012940c9c0a1d7990e8", "input": "Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography.", "output": [ "method" ] }, { "id": "task1163-2df25051f7b84125b5dd6fbc7e43b889", "input": "This assay was evaluated using a serum collection including 45 samples from three commercial farms from Spain.", "output": [ "method" ] }, { "id": "task1163-fe355218830c44cf8fb68f695c464419", "input": "gallbladder , and hepatocellular cancers.", "output": [ "background" ] }, { "id": "task1163-6c141cbbcc0e438c8e108c2b11f59e34", "input": "GW3965 treatment prevented cholesterol accumulation in the perinuclear area of the infected cells.", "output": [ "finding" ] }, { "id": "task1163-84cb69b07a8441de80e8072b26dff22a", "input": "Three days prior , he presented to an emergency department ( ED ) and was sent home after rehydration with normal saline with a reportedly normal chest x-ray ( CXR ).", "output": [ "background" ] }, { "id": "task1163-a4759e31e5e94e129a404cf70cdbf236", "input": "focus will be therefore , given on the immune response to transgene products of the tetracycline inducible promoter.", "output": [ "method" ] }, { "id": "task1163-1655cf4f78f145509c800251c1f31ce2", "input": "no jurisdiction has yet developed a plan to accommodate the anticipated `` surge '' in demand for palliative care.", "output": [ "background" ] }, { "id": "task1163-1d137b8e61dd41da896f34f197675f07", "input": "Here we used myeloid cell specific A20 knockout mice to examine the role of the ubiquitin-editing protein A20 in the response of myeloid cells to IAV infection.", "output": [ "method" ] }, { "id": "task1163-620612497ae442fbaffc641f9845b2cd", "input": "Critical for the development of new treatment approaches is an improved understanding of virus-host interaction in the context of the asthmatic airway.", "output": [ "background" ] }, { "id": "task1163-42a884d28f6245f0a37ac66f5e607994", "input": "as well as the pathogen 's evolutionary rate.", "output": [ "purpose" ] }, { "id": "task1163-c2714cba17b040c5ac32ba781b50865f", "input": "Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients.", "output": [ "background" ] }, { "id": "task1163-e9b6ceac0045460085fe4d943e241ef3", "input": "Postweaning body weight measurements were collected from the heifers at approximately 8 mo of age.", "output": [ "method" ] }, { "id": "task1163-f295f99a992c4512a31e1e0fa7f78add", "input": "The introduction of the 5H2 epitope ablated two epitopes on DENV1 EDI recognized by human MAbs ( 1F4 and 14C10 ) that strongly neutralize DENV1.", "output": [ "finding" ] }, { "id": "task1163-bde00ff18c9d41628e04ee42b9284f51", "input": "This investigation proposed a combined fast fluid dynamics ( FFD ) and Markov chain model for fast predicting transient particle transport indoors.", "output": [ "purpose" ] }, { "id": "task1163-05231afa7e2b4629a5c0e4d48b9a3bff", "input": "1180 laboratory-confi rmed cases ( 483 deaths ; 40 % mortality ) have been reported to WHO.", "output": [ "background" ] }, { "id": "task1163-0fffbddd57e24ef3a497e6b6e369f406", "input": "Some methods of enhancing the analytical performance of sensors and biosensors through their figures of merit are also discussed.", "output": [ "method" ] }, { "id": "task1163-cd3792eb31374424ba7737b9e5e82965", "input": "'' and a culture of organizational justice.", "output": [ "finding" ] }, { "id": "task1163-8b5f9696c9494f76acd8bcafdb56f3ae", "input": "excluding virus only infections , and 3 ) only bacterial infections.", "output": [ "method" ] }, { "id": "task1163-c9fd7374e01a4990926a72b667f23e22", "input": "Here , we propose a simple econometric model that could be useful to predict the spread of COVID-2019.", "output": [ "purpose" ] }, { "id": "task1163-b0fe973c302a4f06bd8812ba38afe8f7", "input": "20 , 30 , and 45 days after inoculation ( dai ) and at 30-day intervals thereafter for the remainder of the 210-day experimental period.", "output": [ "method" ] }, { "id": "task1163-a5d595934f0c4876a78aff86b6460af2", "input": "For this purpose , we have been constructing a knowledge base by organizing various experimental and computational observations as a collection of if-then rules.", "output": [ "purpose" ] }, { "id": "task1163-4bcd22ed2a084f1a95c8a1c64e88dc1d", "input": "age-associated patterns of infection , and undertook phylogeographical and migration analyses to determine intercountry virus transmission after local lineage establishment.", "output": [ "method" ] }, { "id": "task1163-d48344358ecb4a77a511ddf9a5212b40", "input": "The detectability of different methods as well as the auxiliary diagnosis value of antibodies test for SARS-CoV-2 infection were analyzed.", "output": [ "method" ] }, { "id": "task1163-fd4ab079e3444f62b13652a8f2e80293", "input": "residents , fellows , and attending physicians completed written questionnaires on PPE training received during medical school and on knowledge of PPE protocols recommended by the Centers for Disease Control and Prevention.", "output": [ "method" ] }, { "id": "task1163-94f36cc4005742a6b1868c605f8e4460", "input": "This study has evaluated the efficacy of ultraviolet waveband C ( UV-C ) for disinfection of flushing-generated pathogen-laden aerosols through tests with localized disinfection systems for airborne and surface contaminations.", "output": [ "purpose" ] }, { "id": "task1163-7730ce7e81a34a639bd7e9852e3b652a", "input": "a high-risk infectious pathogen , can cause severe acute lung injury leading to significant morbidity and mortality.", "output": [ "background" ] }, { "id": "task1163-aafbb8dc1db74652830e658198f7bebb", "input": "Background : Morbidity and mortality rates of low birth weight ( LBW ) newborns at term are higher than rates in normal birth weight ( NBW ) newborns.", "output": [ "background" ] }, { "id": "task1163-5fc2c89e6a2d46798972aa5eddb41695", "input": "The aim of this study was to establish the minimum dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding cats.", "output": [ "purpose" ] }, { "id": "task1163-a2c8ddea2b90406dbcea7369ede67ffe", "input": "we performed in silico screening of a commercial database of more than 1,300 drug-like compounds by using receptorbased docking studies.", "output": [ "method" ] }, { "id": "task1163-e820d8c9d6924114b8bf753ed569dda4", "input": "to prevent the infection of V. anguillarum in flounder fish , investigated.", "output": [ "purpose" ] }, { "id": "task1163-ce78de1fc90348549304159ca24538d1", "input": "changes following infection are central to the clinical manifestation of disease.", "output": [ "background" ] }, { "id": "task1163-6e029a4864ae4056bbd8a1d53fe995bd", "input": "with a mean R e of 1 · 16.", "output": [ "finding" ] }, { "id": "task1163-49bbeb5760254ebd80ea15c3c108de61", "input": "This suggests that viruses have evolved to have tremendous plasticity in the ability to form membraneassociated replication complexes and that large and numerous DMVs are not exclusively associated with efficient coronavirus replication.", "output": [ "finding" ] }, { "id": "task1163-52ebd26fdc34444f91592e2f6e104677", "input": "Methods : Data were summarized from electronic patient and microbiology files.", "output": [ "method" ] }, { "id": "task1163-1f9ec0a3875c413e9fc9e046fb1ebad2", "input": "Thus , we speculated that knowledge of the functional changes in the NS7b and NS8 proteins during evolution may provide important information to explore the human infective property of 2019-nCoV.", "output": [ "finding" ] }, { "id": "task1163-98aacddce9dd4eb5a40215ffefd48a41", "input": "and small scale physical analogues with water.", "output": [ "background" ] }, { "id": "task1163-163784d0102d46199fad5971ecb621ce", "input": "geese , and swans of all ages and species.", "output": [ "background" ] }, { "id": "task1163-43d6b0b83edf4c229b8010e537f1c20f", "input": "A total of 31 scats were analysed.", "output": [ "method" ] }, { "id": "task1163-9def3c2625fa418a99401dbdaeb50013", "input": "with more than three billion doses administered since its introduction in 1921.", "output": [ "finding" ] }, { "id": "task1163-4a9e8546d9ee4240a08486d642b5c2e9", "input": "The morphology of the disease and serological as well as immunohistochemical results indicate that this disorder is different from previously known feline viral encephalitides.", "output": [ "finding" ] }, { "id": "task1163-3bfd485d5b97451192d7c19e6a51275a", "input": "Methods : Prospective case-control study.", "output": [ "method" ] }, { "id": "task1163-b871f2d272e04490b044b51e47b606b8", "input": "List the most important pathogens currently found on the HHS Category C list.", "output": [ "purpose" ] }, { "id": "task1163-ae111235d65a400c8ee0a32d41583f96", "input": "There is currently no effective treatment available for either HFRS or HCPS.", "output": [ "background" ] }, { "id": "task1163-5d45803b951041fb8eaece4aedb7d688", "input": "but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that could not be achieved using traditional approaches alone.", "output": [ "background" ] }, { "id": "task1163-b497b03e5dcf4de5a75806e31fa4fbe7", "input": "with higher R0 , and with more transmission before symptom onset.", "output": [ "finding" ] }, { "id": "task1163-6b96ddcdbca049448634aa6f64e5fb5f", "input": "virologists and infection control teams to assess the effectiveness of hospital isolation and ventilation facilities.", "output": [ "background" ] }, { "id": "task1163-c19c8447422f45bc8e0859cd54135e77", "input": "Those at greatest risk for acute asthma are those with more severe airways disease and poor asthma control.", "output": [ "background" ] }, { "id": "task1163-a598b543019449c3ae1d212f2fbd81ea", "input": "which is characterized by elevated GFAP expression in astrocytes.", "output": [ "background" ] }, { "id": "task1163-d897f4f7e5c3454e86b55a9a613f8bd0", "input": "In this mini review we discuss type III IFN signaling and its role in microbial pathogenesis with an emphasis on the work that has been conducted with bacterial pathogens.", "output": [ "purpose" ] }, { "id": "task1163-a7d14121ceaf4680af21acc16f1588e3", "input": "The objective of this study was to determine platelet-bound antibodies ( PBA ) by a flow cytometric assay in both healthy and thrombocytopenic cats.", "output": [ "purpose" ] }, { "id": "task1163-f502b1122f0e4349b5fda763207088dd", "input": "Upper limb was the most frequently fractured location.", "output": [ "finding" ] }, { "id": "task1163-3094b2e6870f48b2b3c0e791e85068c8", "input": "Additionally , FMT was performed for 3 consecutive days in 5 geriatric horses with diarrhea using feces from the same healthy donor.", "output": [ "method" ] }, { "id": "task1163-cf3ff363ee42481693d4e1d5f41a97de", "input": "the estimated total number of cumulative cases would be reduced to 1081 ( 981-1177 ) and 758 ( 697-817 ) , respectively.", "output": [ "finding" ] }, { "id": "task1163-37be1f3999c84d3492bc97ed75a854cf", "input": "3C-like proteinase of severe acute respiratory syndrome ( SARS ) coronavirus has been demonstrated to be a key target for drug design against SARS.", "output": [ "background" ] }, { "id": "task1163-a19abc559700465e8ee432e3e94413af", "input": "We analyzed data from 53 consecutive laboratory-confirmed and hospitalized COVID-19 patients ( 28 men , 25 women ; age , 19-81 years ).", "output": [ "method" ] }, { "id": "task1163-07509475b66348c9ba0cfacaf176b736", "input": "which has been exploited in photodynamic therapy ( PDT ) ( 11 , 12 ) for treatment of cancers ( 13 ) and age-related macular degeneration ( 14 ).", "output": [ "background" ] }, { "id": "task1163-13dd629b640743ecb66a2f5f2713208a", "input": "The human severe acute respiratory syndrome coronavirus ( SARS-CoV ) and the NL63 coronaviruses are human respiratory pathogens for which no effective antiviral treatment exists.", "output": [ "background" ] }, { "id": "task1163-a7661dd3de2944aeab7839d1052897b9", "input": "Ten reference genes were investigated for normalization of gene expression data in the shell gland of laying hens.", "output": [ "background" ] }, { "id": "task1163-6faa2946860c4bf49217d1e15a7edde8", "input": "Osteonecrosis of the femoral head ( ONFH ) is a common disabling complication among convalescent SARS patients who received corticosteroid therapy.", "output": [ "purpose" ] }, { "id": "task1163-ed0971146ca64f7ea289d2c2e0e78722", "input": "and the stability during this process is discussed.", "output": [ "method" ] }, { "id": "task1163-f95e230341734d8baa6f5500aa9682d9", "input": "However , only ~ 3 % of the human genome is expressed in protein ; RNA and DNA may form noncanonical secondary structures that are functionally important.", "output": [ "background" ] }, { "id": "task1163-8e869e34f3ec47a09885714a87ac800a", "input": "Eighty-seven waterborne outbreaks involving extreme water-related weather events were identified and included , alongside 235 ProMED reports.", "output": [ "method" ] }, { "id": "task1163-ff64d823ea9e40df9fcb09e71a9c74cf", "input": "Multiplex PCR has become the test of choice for the detection of multiple respiratory viruses in clinical specimens.", "output": [ "background" ] }, { "id": "task1163-284dcaa8f4c34136957162b5e057a38a", "input": "however had an impact on virus egress.", "output": [ "finding" ] }, { "id": "task1163-91c022ec91614f68a7832694476e7da1", "input": "as was the election of Donald Trump as US president.", "output": [ "background" ] }, { "id": "task1163-089d8503dee2432d824e7f42ddb9c3e7", "input": "and did not differ significantly from the SYBR Green quantitative PCR assay ( p > 0.05 ).", "output": [ "finding" ] }, { "id": "task1163-90c4553fca0449e7b85a7e1985fa0b87", "input": "Cell surface iodination identified virus-specific proteins expressed on BALB/cV primary mammary tumor cells grown in culture.", "output": [ "finding" ] }, { "id": "task1163-b1668c5c07524e61bc0ebc592174b11e", "input": "Objective : This study presents a preliminary report on the chest radiographic and computed tomography ( CT ) findings of the 2019 novel coronavirus disease ( COVID-19 ) pneumonia in Korea.", "output": [ "purpose" ] }, { "id": "task1163-7d861b8c60e84ff2a29c30f9ffda54d1", "input": "Basic scientific research is now considered an integral component of the fight against emerging infectious diseases like Ebola virus.", "output": [ "background" ] }, { "id": "task1163-ebd9264dd903414cbd237f2ffa674c27", "input": "Eukaryotes and bacteria can be infected with a wide variety of RNA viruses.", "output": [ "background" ] }, { "id": "task1163-1ff9f2ddad44414c9ad1350c1cefc5b2", "input": "Ad12 DNA usually integrates at one chromosomal site which is not specific since Ad12 DNA can integrate at many different locations in the hamster genome.", "output": [ "background" ] }, { "id": "task1163-1d2360999897481094b5d47891201fe2", "input": "virologic , and epidemiologic characteristics of URIs in a population of 4 to 7 year old children followed for one year.", "output": [ "purpose" ] }, { "id": "task1163-e36c4b01015c40edbb29d290a89f6e82", "input": "Even with optimal treatment , mortality is about 30 % ( 1-3 ).", "output": [ "background" ] }, { "id": "task1163-2fcf6ba90a7241d595941bb6708eb0c0", "input": "Objective/Methods : An exhaustive review of literature was performed to investigate available data and evidences regarding pediatric otolaryngologic manifestations of viral systemic infections.", "output": [ "purpose" ] }, { "id": "task1163-a5bb4ebb5a21411a8545cadf648f385a", "input": "and 70 % were females.", "output": [ "finding" ] }, { "id": "task1163-6b6fa783cb594c7cb6f8c547590177ab", "input": "but as a consequence , a variety of different 3CLpro expression constructs and kinetic assays have been independently developed making evaluation and comparison between potential inhibitors problematic.", "output": [ "background" ] }, { "id": "task1163-05cea83fcf454ce88819b27d0dc4139c", "input": "Here , we report the identification of a novel bat coronavirus through surveillance of coronaviruses in wildlife.", "output": [ "purpose" ] }, { "id": "task1163-acb288d30cc0467586b9269d1ca0c229", "input": "We report the clinical , virological and serological findings in dogs experimentally infected with strain CB/05.", "output": [ "purpose" ] }, { "id": "task1163-a71ca3dfbdf54d818be609bedc4478a7", "input": "The on-chip RPA was characterized in terms of reaction time , sensitivity and inhibitory conditions.", "output": [ "method" ] }, { "id": "task1163-dc886f14baa64ff0ae51e82fad12f5cc", "input": "We report the changing epidemiology of travel-related illnesses over a 12-year period.", "output": [ "purpose" ] }, { "id": "task1163-3d59a5832ee04340bce6124f06ad08ba", "input": "Methods : Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-inflammatory actions of K-601.", "output": [ "method" ] }, { "id": "task1163-d3346eca1ced4f11bff6035bd529ebec", "input": "Objective : The goal of this study was to characterize the radiographic presentation of children with SARS.", "output": [ "purpose" ] }, { "id": "task1163-971aaffb773a4d5fad53b5784fc7c27d", "input": "spring source water , and water from the public water supply system.", "output": [ "purpose" ] }, { "id": "task1163-2484d0e1b10d4556a4fc868d2834fbc7", "input": "63 susceptible vectors , S v ; and infected vectors , I v.", "output": [ "method" ] }, { "id": "task1163-3a3a04922ee84d7285989d82e890ae20", "input": "also plays a key role in the outcome of infection.", "output": [ "background" ] }, { "id": "task1163-7ec8496493f442e487b8c352bc428dfd", "input": "Surveillance systems using influenza-specific code for reporting tend to reflect biases of both healthcare seekers and providers.", "output": [ "finding" ] }, { "id": "task1163-47e7343d447542bdb6536d47cf943e60", "input": "These samples were tested by reverse transcription loop-mediated isothermal amplification and a real-time reverse transcription-polymerase chain reaction.", "output": [ "method" ] }, { "id": "task1163-4ed19685212d4807a3895e7949179fd6", "input": "virus budding was substantially decreased and infectious virions were reduced by more than lOOO-fold in the supernatant medium.", "output": [ "finding" ] }, { "id": "task1163-b47b3255002c4cf9ba39c0cf5bb2e06e", "input": "live H120 + CR88 , or VG/GA-Avinew + H120 + CR88.", "output": [ "method" ] }, { "id": "task1163-aab1971f58234e6bb10481cb27858e69", "input": "tissue tropisms , and host range.", "output": [ "method" ] }, { "id": "task1163-fe2dc3f3eb5f45c1bf7064c49b547f3b", "input": "and the correlation between cleavage and induction of cell-to-cell fusion.", "output": [ "background" ] }, { "id": "task1163-8c79bf6ffb2f4b09af8e56c2c2cb9d53", "input": "determining only a single parameter.", "output": [ "background" ] }, { "id": "task1163-a684fea1d1474c4e80f36918b3bc9ddb", "input": "This argument has profound implications because it suggests that pathogenesis in many viral infections depends on rare or de novo mutations.", "output": [ "background" ] }, { "id": "task1163-9b5bc54adbae42f8b3c8ce5794d92f84", "input": "These antibodies can be concentrated and used to formulate so-called immune milk preparations.", "output": [ "background" ] }, { "id": "task1163-a255d9deff0649f79a5f7976d936c1cf", "input": "with the prostate cancer antigen ( PSA ) being one of many such examples.", "output": [ "background" ] }, { "id": "task1163-0db2596b885b4324bfdd0ee1b8eb5059", "input": "Distant phylogenetic species usually has greater variations in codon usage bias ( 18,19 ).", "output": [ "background" ] }, { "id": "task1163-877fc53f784b44c79186edef2bb77884", "input": "which are the leading cause of child mortality.", "output": [ "purpose" ] }, { "id": "task1163-80e38ffe1bff4bed92490a563d317b00", "input": "In the following years the role of rats and fleas and their detailed role in the transmission of plague has been discovered and experimentally verified.", "output": [ "finding" ] }, { "id": "task1163-f5da76de9ecb42d289d2c2ca0dcc723d", "input": "we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens.", "output": [ "background" ] }, { "id": "task1163-071fbb3fa07742c2811e6fb1ddaccf0c", "input": "allowing calculation of virus-specific attributable fractions in the exposed ( AFE ) to determine the proportion of virus-positive children whose ARI symptoms could be attributed to that particular virus.", "output": [ "method" ] }, { "id": "task1163-c1df07d50e1c481798e54e7f7ade0651", "input": "Here we describe a novel endonuclease IV ( Endo IV ) based assay utilizing a substrate that mimics the abasic lesions that normally occur in doublestranded DNA.", "output": [ "purpose" ] }, { "id": "task1163-dee213d635fc4b739dfe57725638b6f4", "input": "Kittens ( n = 23 ) were injected with rFeIFN ( 1 MU/kg subcutaneoulsy , once a day for 3 days ) and their blood parameters were compared with those of 17 untreated cats.", "output": [ "method" ] }, { "id": "task1163-85c6dd8a8b8e484d8babf47f28f3a194", "input": "and S84A in the Friend mouse leukemia virus F-S MLV.", "output": [ "background" ] }, { "id": "task1163-386668d2842a4decbd99be632c08cb53", "input": "thereby clamping the RNA substrate onto eIF4A and causing inhibition of the translation initiation complex.", "output": [ "background" ] }, { "id": "task1163-53a8f0458e26461cb64589280d9fbeaf", "input": "but the protective efficacies of these vaccines are uncertain.", "output": [ "background" ] }, { "id": "task1163-872454aae15740cea22d2d5503b59f06", "input": "In particular the use of protein microarrays has surged as a powerful tool for large scale testing of biological samples.", "output": [ "background" ] }, { "id": "task1163-87d05ca8280c42f28be4af2e22d49ef2", "input": "We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation.", "output": [ "purpose" ] }, { "id": "task1163-1d5edc4369794b01b778c1934907e112", "input": "We describe a new method for affinity purification of recombinant proteins using a dual protease protocol.", "output": [ "purpose" ] }, { "id": "task1163-cc985d10f5b44f7f95007e317994c1e5", "input": "product , and phosphorothioate analogues.", "output": [ "finding" ] }, { "id": "task1163-26a443d978334ad4b176169159f86a9e", "input": "TRIM25 acts as a clamp to inhibit viral RNA chain elongation d TRIM25 restriction of influenza RNA synthesis can be reconstituted in vitro d Influenza NS1 protein antagonizes this anti-influenza activity of TRIM25 SUMMARY TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response.", "output": [ "background" ] }, { "id": "task1163-0ce5d84db04747cb9f4eb844c49f8368", "input": "Duckweed is also fed to animals as a diet complement because of its high nutritional value.", "output": [ "background" ] }, { "id": "task1163-ca825d38f8114294b39aa183ec9e903e", "input": "Inter-simple sequence repeat ( ISSR ) markers were used to assess the level and distribution of genetic diversity in 226 individuals from 15 populations of H. cordata in China.", "output": [ "method" ] }, { "id": "task1163-fbbe76f81350446d9e234df0bd78b34e", "input": "suspended material within this air in a hospital setting.", "output": [ "background" ] }, { "id": "task1163-55a7451ee05a460c81f4bd8318c13bae", "input": "The purified N protein was well folded and was predominantly alpha-helical.", "output": [ "method" ] }, { "id": "task1163-d3d3b928089349a78434e4a42f1e6d27", "input": "for predicting localization sites of proteins only from the information on the amino acid sequence and the source origin.", "output": [ "purpose" ] }, { "id": "task1163-02015749b56d454e92858a438368ce71", "input": "or in autophagy deficient-MDBK cells.", "output": [ "finding" ] }, { "id": "task1163-7e8278563797413ebfb3a54116e17581", "input": "Our studies reveal that alteration of the function of cellular GLTSCR2 plays a role in supporting viral replication.", "output": [ "finding" ] }, { "id": "task1163-73f376396c414b9f81ec5392abc54d8a", "input": "In our study , we demonstrate that nonidentifiability in model calibrations using the confirmed-case data is the main reason for such wide variations.", "output": [ "purpose" ] }, { "id": "task1163-2a03015ee7104178888e868975713cfb", "input": "and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle.", "output": [ "purpose" ] }, { "id": "task1163-1bdd49e55a19434ab7b9f225e2a778e7", "input": "based on individual-level data and transmission tree information.", "output": [ "method" ] }, { "id": "task1163-53f17af67ef54fff897b8fbc5781095b", "input": "which invades the central nervous system ( CNS ) via peripheral nervous system and causes encephalomyelitis or vomiting and wasting disease ( VWD ) in sucking piglets.", "output": [ "background" ] }, { "id": "task1163-e79dfacdabfb49e988fc06b3768f8813", "input": "On this note , travel restrictions to and from high risk areas and/or 14 days quarantine of travelers coming from high risk areas are recommended to prevent possible importation of COVID-19.", "output": [ "background" ] }, { "id": "task1163-798797e6882d47b796d8ef2e1102ad6f", "input": "In the present study , we screened plasma of 88 HIV-1 infected ART naïve individuals for their neutralization potential using a standard panel of 18 pseudoviruses belonging to different subtypes and different levels of neutralization.", "output": [ "purpose" ] }, { "id": "task1163-949030bdac80416c8fb5322b51c77b2e", "input": "a multi-module software package for analyzing VirScan datasets.", "output": [ "purpose" ] }, { "id": "task1163-70c794d4046240b686e6ade2d3a94c28", "input": "has been approved to treat inflammatory-related diseases , such as pancreatitis.", "output": [ "background" ] }, { "id": "task1163-dc8b8f46e53a420d88a5ce261804b5a1", "input": "Producer records of disease treatment and mortality were collected 120 d following diagnosis.", "output": [ "method" ] }, { "id": "task1163-7a34e8d02a83446dac11fe942e00d44b", "input": "challenges , limitations , and future research needs.", "output": [ "purpose" ] }, { "id": "task1163-15929715858c49aca78d17d6b3d76122", "input": "numerous white ovalshaped organisms were firmly embedded in the mucosa and there was thickening of intestinal wall.", "output": [ "finding" ] }, { "id": "task1163-d7662fd15b044107a46efa08fddc8985", "input": "experts and the onsite command system and organizations at regional level ; and how to solve some of those problems.", "output": [ "background" ] }, { "id": "task1163-8cc4f3de138c4883940c4eb64032ec16", "input": "To investigate the long-term effects of mild H1N1 influenza infection on the pulmonary function of a cohort of patients.", "output": [ "purpose" ] }, { "id": "task1163-2bb90a807f2e4e12820f2e4ca73dc93b", "input": "codon known as synonymous codons.", "output": [ "background" ] }, { "id": "task1163-3d1215c2af60465bb4e9e0bae2481b00", "input": "In this paper , the molecular connectivity indices were applied to theoretically predict the direct chemiluminescence ( CL ) behavior of chrysin and baicalein with our recently proposed discriminant function.", "output": [ "purpose" ] }, { "id": "task1163-1f45abafcace409d87d810190189c43c", "input": "and five viruses found in the subspecies Nyctereutes procyonoides ussuriensis in its original and newly occupied habitat or in Nyctereutes procyonoides koreensis in its original habitat , respectively.", "output": [ "background" ] }, { "id": "task1163-6fdc8ac4520142c29460bab23ec7e6fa", "input": "22 , 726 , and 726 molecules per virion , respectively.", "output": [ "finding" ] }, { "id": "task1163-ba861ffc4e864ec18798285fbb92599d", "input": "mouse hepatitis virus and transmissible gastroenteritis virus.", "output": [ "purpose" ] }, { "id": "task1163-1521d7078c8a473ca960a8e6c6441cab", "input": "design of highly expressed genes and cloning vectors and reveal about the host-pathogen coevolution and adaptation of pathogens to specific hosts ( 20,21 ).", "output": [ "background" ] }, { "id": "task1163-9c2566a27f4b4832b246e66bb19925a8", "input": "compared to mock-treated , infected mice.", "output": [ "finding" ] }, { "id": "task1163-7acb388906484c998c327475e9805584", "input": "Here we show a transparent photonic nanostructure inspired by the longtail glasswing ( Chorinea faunus ) butterfly and demonstrate its use in intraocular pressure ( IOP ) sensors in vivo.", "output": [ "purpose" ] }, { "id": "task1163-e0171a8470da4adabfb204b17e833d60", "input": "Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections.", "output": [ "purpose" ] }, { "id": "task1163-448ef5ae81a541b2806db61ae14534ee", "input": "Pulmonary physiologic changes during pregnancy are discussed in detail elsewhere in this issue.", "output": [ "purpose" ] }, { "id": "task1163-58c5501f19d74a59a5d2be8ac5d49ce2", "input": "as a monotherapy or in combination with anti-PD-1 treatment.", "output": [ "finding" ] }, { "id": "task1163-c1974a30c32d40ed852a781777db8e52", "input": "They share this function with macrophages derived from the same basic hemopoietic ( bone marrow-derived ) precursor and with parenchymal microglia that arise from a unique nonhemopoietic origin.", "output": [ "background" ] }, { "id": "task1163-b6258d1450d94e3191cbaa959554fb99", "input": "for pre-and post-exposure prophylaxis of acute arenaviral infection modeled in hamsters.", "output": [ "purpose" ] }, { "id": "task1163-2ea4d7b14d0541478b5da39fe050604c", "input": "Our goal was to examine donor AM longevity and evaluate whether AM of recipient origin seeds the transplanted lungs.", "output": [ "purpose" ] }, { "id": "task1163-1dd185b9f132468781f56a2806d3320b", "input": "and the role of health authorities in minimizing risk to the public.", "output": [ "purpose" ] }, { "id": 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'' a DCL depends on the type of reaction that is used.", "output": [ "background" ] }, { "id": "task1163-44512e5da0a746a29ff8bebdffdc4372", "input": "This study was undertaken to clarify the role of the reninangiotensin system ( RAS ) in the progression of severe HFMD.", "output": [ "purpose" ] }, { "id": "task1163-622e65f9f0d24e79b76c29b3940b36e3", "input": "and on the roles of viral ubiquitin-like sequences.", "output": [ "purpose" ] }, { "id": "task1163-9593994f0d6042d9af5353d9f8263e55", "input": "Nancy , to examine viral replication and pathogenesis in orally inoculated mice.", "output": [ "method" ] }, { "id": "task1163-907b9e507d2c4f53bab746e237be24cb", "input": "Discuss the prohibited uses of biological agents under international law.", "output": [ "purpose" ] }, { "id": "task1163-028f93ec6b704ddfa9f7add18a4e2c17", "input": "clinical trials devoted to validating the clinical applications and underlying mechanisms are needed in the future.", "output": [ "finding" ] }, { "id": "task1163-08ac20ac609b45a8af8fa6143690171b", "input": "thus utilizing its highly efficient translation initiation site.", "output": [ "method" ] }, { "id": "task1163-4f09032a99714c169d0a43dd098ca3fe", "input": "The BALB/cV subline was used to study the molecular basis of potential virus-host interactions involving cell surface-expressed MMTV proteins.", "output": [ "method" ] }, { "id": "task1163-aae3f6e40f964dbebebef4e571969cf9", "input": "Antibodies generated from these aneurysmal plasma cell infiltrates showed cross-reaction to intracellular inclusions in the bronchial epithelium of a number of pathologic specimens from children with KD.", "output": [ "background" ] }, { "id": "task1163-709654ec8c7347caaa48a72d49d0a411", "input": "each with a spike of a single type.", "output": [ "finding" ] }, { "id": "task1163-a832c61530684897aac58a9663b44bd0", "input": "which may result in treatment delay and chronic lung function impairment.", "output": [ "background" ] }, { "id": "task1163-151d644984064d069b5290d152eb4041", "input": "The signal sequences of these glycoproteins are located internally in the primary translation product.", "output": [ "method" ] }, { "id": "task1163-1b21ffa770aa4da8a7a4aeb03042eaa1", "input": "and then tested in SPF chickens.", "output": [ "method" ] }, { "id": "task1163-e0f2d0877e2341ec908068c52d426fbf", "input": "a cytotoxin that causes leukocyte destruction and tissue necrosis ( 1 ).", "output": [ "background" ] }, { "id": "task1163-0142d832566d4a0ba1619aaa54fb76e9", "input": "Here , we summarize current knowledge on direct and indirect transmission routes of bat infectious agents of public health concern ( Fig 1 ).", "output": [ "purpose" ] }, { "id": "task1163-997d27c502654d21a7d276360254e3ea", "input": "Virus prevalence was higher in local camels than in imported camels ( 224 ( 47 · 5 % ) of 472 vs 157 ( 13 · 1 % ) of 1196 ; p < 0 · 0001 ).", "output": [ "finding" ] }, { "id": "task1163-3a865d583842425ba99ad1929c867eb8", "input": "We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes ( CTLs ) against severe acute respiratory syndrome ( SARS ) coronavirus ( SARS-CoV ).", "output": [ "purpose" ] }, { "id": "task1163-f8c2b92e82644ee6bc7fce63407379b6", "input": "or mass spectrometry , while the introduction of closed-tube systems has resulted in rapid microbial diagnostics with a subsequently reduced contamination risk.", "output": [ "background" ] }, { "id": "task1163-e180ee2a125b49ccaea52c85ad339935", "input": "This study aimed to determine the aetiology of community-acquired pneumonia ( CAP ) by adding polymerase chain reaction ( PCR ) to conventional methods and to describe the clinical and laboratory features between patients with bacterial pneumonia ( BP ) and viral pneumonia ( VP ).", "output": [ "purpose" ] }, { "id": "task1163-62a16e15f05f481b8e7646ce7cbfc96d", "input": "motion , skin tone , and distance variance.", "output": [ "method" ] }, { "id": "task1163-a948f4aabfb54ee48cc1bda9fba1912f", "input": "This review describes the suppressive effects of CsA on coronavirus replication.", "output": [ "purpose" ] }, { "id": "task1163-3d44a2243d694d56b528f7f6174e1d35", "input": "Treating affected patients with intravenous immunoglobulin is effective at reducing the rates of coronary aneurysms.", "output": [ "background" ] }, { "id": "task1163-fa5dde543af04842beffdadb5a320f35", "input": "namely a better condition may lead to worse performance.", "output": [ "finding" ] }, { "id": "task1163-626d1fe837a84f0393124741408eb6d0", "input": "and provide future perspectives on how novel model systems could be utilized to better define the role of viral pathogens in M.", "output": [ "purpose" ] }, { "id": "task1163-5b2e1d76baae4bd4a8f324b4193f3720", "input": "induces apoptosis in infected cells at late times postinfection.", "output": [ "purpose" ] }, { "id": "task1163-04d64f4d347145399f10659f49239a96", "input": "The theoretical domains framework ( TDF ) was used to aid thematic analysis and identify relevant enablers of and barriers to optimal PPE use.", "output": [ "method" ] }, { "id": "task1163-a99a5ee898fa476296731db7d7e8843f", "input": "and examined by RT-PCR targeting the RdRp gene for the presence of CoV RNA.", "output": [ "method" ] }, { "id": "task1163-51a69f9841994a3f99f8f280e72bfd0f", "input": "alleles across 3 distinct loci in a feline species.", "output": [ "method" ] }, { "id": "task1163-8d3fc733aafa4e0694502e1e8c18bba2", "input": "complicating its assessment as a primary pathogen.", "output": [ "background" ] }, { "id": "task1163-4f99edd6107742758963ae098b4e9ae0", "input": "Cases of MERS-CoV infection were identified using 3 US Centers for Disease Control and Prevention serologic tests for detection of anti-MERS-CoV antibodies.", "output": [ "method" ] }, { "id": "task1163-54a5139459c94a71bf1a4f06578ce786", "input": "The acute respiratory distress syndrome ( ARDS ) is a lethal inflammatory disorder of the lung.", "output": [ "background" ] }, { "id": "task1163-94c3925afd284f6c96946fb8cbefb3f0", "input": "and only three samples ( 2.5 % ) collected from healthy foals were positive for ECoV.", "output": [ "finding" ] }, { "id": "task1163-acda2881a26c42c9b71cccf99dc0171e", "input": "All contacts were screened for MERS-CoV using polymerase chain reaction.", "output": [ "method" ] }, { "id": "task1163-e08fb7c45089467391333e3aabe9a0cc", "input": "We hypothesise that the local airway immune response to RSV has incidental antibacterial effects.", "output": [ "purpose" ] }, { "id": "task1163-45e8669288bf4a36b4c502f9b8120e54", "input": "Thus , the objective of this study was to corroborate the results of our prior clinical trial across multiple farms and to investigate the effect of lactoferrin on the morbidity and mortality of preweaned calves with naturally occurring cases of diarrhea.", "output": [ "purpose" ] }, { "id": "task1163-1f9642f9033b4cfd81dd72147b413e80", "input": "Findings : The early outbreak data largely follows the exponential growth.", "output": [ "finding" ] }, { "id": "task1163-3ee0e1075cc74120bf8c90a980dbffaa", "input": "However , there is increasing evidence of cross-reactivity between amyloidforming polypeptides.", "output": [ "background" ] }, { "id": "task1163-0a67af6d29ea408684c85e907b0ef1b7", "input": "We evaluated the association between serum procalcitonin concentration at hospital admission with pathogens detected in a multicenter prospective surveillance study of adults hospitalized with community-acquired pneumonia.", "output": [ "method" ] }, { "id": "task1163-7aea7655ddbd4be7901a7ff84d164de1", "input": "By using analytical methods we intend to uncover the dynamical properties of the 48 diseases with two routes of transmission.", "output": [ "purpose" ] }, { "id": "task1163-8c5d0e5a3cb146cea72406214487df8c", "input": "Objectives : We compared the expelled air dispersion distances during coughing from a human patient simulator ( HPS ) lying at 45u with and without wearing a surgical mask or N95 mask in a negative pressure isolation room.", "output": [ "purpose" ] }, { "id": "task1163-f3f733cb7ea9450a870a05b5505b44d4", "input": "emerged in the Arabian Peninsula.", "output": [ "background" ] }, { "id": "task1163-f36856d8361c41cd8a03f99c0dde654f", "input": "Risk factors associated with psychological distress were identified.", "output": [ "finding" ] }, { "id": "task1163-083fa62fb83946018a5f32581b1e5a14", "input": "Finally , biochemical assays also demonstrate that MPA can inhibit DNA ligases through inhibition of the second step of the reaction.", "output": [ "finding" ] }, { "id": "task1163-13fb612504c1492e90a3654cc210a400", "input": "for use in designing an incentive structure to promote patient safety.", "output": [ "purpose" ] }, { "id": "task1163-8d8c52d27e1845918ca2cc6c77e67e14", "input": "As such , there are numerous players involved to ensure that the proteins are properly localized.", "output": [ "background" ] }, { "id": "task1163-e6e71683a7074e61bb26727ea13e38f4", "input": "A series of b-amino alcohol tethered 4-aminoquinoline-isatin conjugates were synthesized with the aim of probing their antimalarial structure activity relationship.", "output": [ "purpose" ] }, { "id": "task1163-5601f1f16a7d497fb7e9d95fcb2f4116", "input": "Interleukin 2 ( IL-2 ) is one such key cytokine.", "output": [ "background" ] }, { "id": "task1163-d8a856a280a942d1a0441a6208fa8731", "input": "We identified 2481 records and 120 records were ultimately included after a first and second screening.", "output": [ "method" ] }, { "id": "task1163-e233ed0777e84fd59d50534c45c884df", "input": "In this review , self-replicating vectors are described and their applications for preclinical studies and clinical trials are discussed.", "output": [ "purpose" ] }, { "id": "task1163-e30cf2cb8a5648fbb1353b9a409dc6f4", "input": "discovery and structureeactivity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.", "output": [ "purpose" ] }, { "id": "task1163-e60616d8baa44615942c1354a544b10e", "input": "Together , these data suggest that a single Gag complex associates `` quantally '' with an individual lipid raft microdomain to assemble functional virions during infection.", "output": [ "finding" ] }, { "id": "task1163-5e1a2471d6e545ef953e5242ad092b5b", "input": "i.e. between infected patients and healthcare workers , and between distant locations.", "output": [ "background" ] }, { "id": "task1163-7530b7d0d50f403fa42e858d48019220", "input": "we have established The Vietnam Initiative on Zoonotic Infections ( VIZIONS ).", "output": [ "purpose" ] }, { "id": "task1163-d9de10dd41194e6b9db668390125b210", "input": "The proportion of influenza-associated deaths was 11.3 times higher in persons age > 65 years than in the general population.", "output": [ "finding" ] }, { "id": "task1163-bc3a5d48badf4ea19102acd4945e7524", "input": "populations encountered distinct pathogens , and natural selection increased the prevalence of alleles that are advantageous in the new ecosystems in both host and pathogens.", "output": [ "background" ] }, { "id": "task1163-712af677ad76451e9bcfeb8f2d9bfb17", "input": "Vitamin D 3 significantly reduced the risk of laboratory confirmed URTI and may reduce the risk of clinical infections.", "output": [ "finding" ] }, { "id": "task1163-11d2fcb9fe614cb38d27de083bf6b4e0", "input": "Both nasal and oropharyngeal swabs were sampled from each dog and subjected for CIRDC virus detection using multiplex PCRs.", "output": [ "method" ] }, { "id": "task1163-e80e551b516f4a4cb7bf7b51115ceddb", "input": "Our results provide important insight to our basic knowledge of immunosenescence and immune defenses to invading pathogens.", "output": [ "finding" ] }, { "id": "task1163-cde35912e6a64ebd84150a931529ddcb", "input": "Escherichia coli , and Salmonella typhimurium.", "output": [ "method" ] }, { "id": "task1163-6cd1c0b2ee1e4a61bfc5da4cb02170a0", "input": "Recombinant proteins are traditionally limited to linear configuration.", "output": [ "background" ] }, { "id": "task1163-886f4bbb484f44fb9805156704ec2c30", "input": "Multiplex PCR was used to identify common respiratory viruses in both sample types and the infection rate was compared between groups.", "output": [ "method" ] }, { "id": "task1163-dee21f48d8d04adca5baef8486eb8ec1", "input": "This is followed by cleavage at the Q 3086 - S 3087 site.", "output": [ "finding" ] }, { "id": "task1163-268772e38cb844b19c4754af4fffd71d", "input": "involving both IFN induction and effector mechanisms.", "output": [ "background" ] }, { "id": "task1163-823ecf052a594e108147148d500de211", "input": "This study aimed at testing whether IL-12 profiles may be indicative of heavy metals-induced immunomodulation.", "output": [ "purpose" ] }, { "id": "task1163-fca54d6065bd4ff48dcd0be90ea12e27", "input": "small ruminants ( goats and sheep ) , poultry , and pigs.", "output": [ "purpose" ] }, { "id": "task1163-606c691f9e9f4af0b1d150aa81f2409a", "input": "We previously identified the antiviral activities of the scorpion-venom-peptidederived mucroporin-M1 for three RNA viruses ( measles viruses , SARS-CoV , and H5N1 ).", "output": [ "background" ] }, { "id": "task1163-2fef207146d344da8bbe5df1ebceb691", "input": "Therefore , the aim of the current study was to develop a diagnostic set for the detection of respiratory viruses with sensitivity as low as 1-10 copies per reaction.", "output": [ "purpose" ] }, { "id": "task1163-c3b225f316ec40d4917287b5ba222a1e", "input": "whereas upregulation of several immunoglobulin genes during chronic stage infection is unique to infection with the demyelinating strain.", "output": [ "purpose" ] }, { "id": "task1163-033a7e6bdb944327837bee5ebfe5bb3e", "input": "deaths and recovered for the whole country.", "output": [ "purpose" ] }, { "id": "task1163-261d9b6a26164869acb0a1812bd11cc5", "input": "while SIgA decreased when CTSL was knockdown or inhibited with E64.", "output": [ "method" ] }, { "id": "task1163-b23cfc11085a46bc8156a84636ec8bc0", "input": "Viruses can disseminate via the bloodstream or through nerves.", "output": [ "background" ] }, { "id": "task1163-42ebbbb1b9dd41a3abc478548eecea4f", "input": "The present review aims at discussing the characterization and relevance of this post-translational modification that adds a new complexity in the already intricate host-apoptosis-virus triangle.", "output": [ "purpose" ] }, { "id": "task1163-095320fc129f4514a7d5db91269c5869", "input": "The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones.", "output": [ "finding" ] }, { "id": "task1163-1d65db06ffe24ea793786efe3863d9e3", "input": "fusion with the outer nuclear membrane and final envelopment at the trans-Golgi network.", "output": [ "background" ] }, { "id": "task1163-a5f67c7a58424b1687547fb6f997464a", "input": "we extrapolated a timescale for a relevant subset of flaviviruses whose evolutionary history , shows that different Culex-spp.", "output": [ "method" ] }, { "id": "task1163-6df592fa1e9549cd82ecd5d0417e6850", "input": "Third , the government is providing treatment for infected individuals.", "output": [ "method" ] }, { "id": "task1163-93141d6a019d4b20a57f0a90d6bd1933", "input": "we also examine sensitivity to assumptions about the duration of infectiousness.", "output": [ "method" ] }, { "id": "task1163-066b705cdb0f4245b513ef4a79f4e4b7", "input": "In this study , we attempted to find out protein domains on 3a that are essential for its pro-apoptotic function.", "output": [ "purpose" ] }, { "id": "task1163-d46e6453835849ffb3816699fc742fa7", "input": "we characterized the infiltrating leukocyte response to the PHA skin test in bats by examining a time-series of histological sections from PHA and saline injection areas in 41 Brazilian free-tailed bats ( Tadarida brasiliensis ).", "output": [ "method" ] }, { "id": "task1163-56b7652760ee49c7b5479fb0cb0b310a", "input": "of which 10 are primarily associated with Culex spp. mosquitoes.", "output": [ "method" ] }, { "id": "task1163-ea1fedbbef194e559e5cded3383896cb", "input": "and 2 min at 72 °C for terminal elongation ( 5 ).", "output": [ "method" ] }, { "id": "task1163-de775e3b927848a6bda6e3e1e7536202", "input": "DNA is widely recognized as a double-helical structure essential in genetic information storage.", "output": [ "background" ] }, { "id": "task1163-2ddf3beaac6646878f7ee82481d93385", "input": "Our study demonstrates an important fact that a better condition for individuals may yield a worse outcome for the society.", "output": [ "finding" ] }, { "id": "task1163-ae5ace3d96c24d7187ce877cbd0b5634", "input": "Furthermore , we noted the effects of extended periods of a heavy workload and daily life.", "output": [ "finding" ] }, { "id": "task1163-4667ca5567b84605a12d8afe5ac89554", "input": "which can induce sickness symptoms.", "output": [ "purpose" ] }, { "id": "task1163-beef30b0479c4ab1bb684a68804b7624", "input": "The in-hospital mortality rate was lowest ( 33.5 % ) in the youngest patients ( age 18-29 years ) and highest ( 68.2 % ) in the oldest patients ( > 80 years , P < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-a2ba2614cf44469f871d8533e6c1900a", "input": "Samples obtained from farms experiencing PED or TGE were quantified between 10 2 and 10 5 RNA copies.", "output": [ "method" ] }, { "id": "task1163-21a6a36d43ab4e0db5169fcc68fb9daf", "input": "Investment in a better understanding of this human-animal interface will offer humankind a future head-start in the never-ending battle against infectious diseases.", "output": [ "finding" ] }, { "id": "task1163-c0c4baa7f51e4a4392d8c0472e75ab5d", "input": "we built a mathematical model of the virus transmission dynamics that takes into account the protective effect of ABO natural antibodies.", "output": [ "method" ] }, { "id": "task1163-96cf49b41b5947ffadc6b6512108cfe2", "input": "relatively little is known about its precise mechanism of action.", "output": [ "background" ] }, { "id": "task1163-3b44e0737df544d0b53d64a5f27aedc5", "input": "can be reduced to the corresponding amines , rendering them irreversible.", "output": [ "background" ] }, { "id": "task1163-fc44ed576b564bb5aff4eea6bd2ecae7", "input": "Cases were more likely to be identified in September than October ( OR 8.07 ; 95 % CI 5.15 to 12.64 ).", "output": [ "finding" ] }, { "id": "task1163-60da852e04f34f4c8323e5df6c29aa3d", "input": "understanding these processes is essential ( 7 ).", "output": [ "background" ] }, { "id": "task1163-855d615e1d224501817a1a699b49f12f", "input": "Sequence analysis revealed the presence of potentially 37 and 56 coronavirus belonging to alpha-coronavirus ( αCoV ) and beta-CoV ( βCoV ) , respectively.", "output": [ "finding" ] }, { "id": "task1163-a7d93d85a04847ccaa1628f926afdddc", "input": "Immune thrombocytopenic purpura ( ITP ) is an autoimmune disorder that causes isolated thrombocytopenia.", "output": [ "background" ] }, { "id": "task1163-29581631f14d412487e6e5f1043988f5", "input": "Here , we present algorithmic and methodological enhancements in the Cavbase property description and in the cavity comparison step.", "output": [ "method" ] }, { "id": "task1163-6de44b91d09e4e3ea3ffa64861f06930", "input": "and this has important implications for the growing field of medical genomics.", "output": [ "background" ] }, { "id": "task1163-22bbba2c17244227ab68145695af0b24", "input": "and suggestions put forward for making collaborative efforts.", "output": [ "purpose" ] }, { "id": "task1163-94ff6799338e4e85b05c7bdd8c0b881d", "input": "This study describes the economic burden on patients with tuberculosis ; identifies related factors by comparing two areas with different management models ; and provides policy recommendation for tuberculosis control reform in China.", "output": [ "purpose" ] }, { "id": "task1163-e85cc7da11d443aea7931dac4c01830b", "input": "The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-75fd0bffed27451787e430561938e964", "input": "some virus exchange was observed between countries corresponding with trade routes in the region.", "output": [ "finding" ] }, { "id": "task1163-be5eee8b310443d3a21721e5146db48c", "input": "These data will also help inform about the role of pertussis vaccination in adults.", "output": [ "finding" ] }, { "id": "task1163-1540d53d83674294814b04d8b19c7044", "input": "Here we take advantage of the latest advances in statistical machine learning to construct 43 pathogen-risk models that automatically incorporate complex non-linear relationships 44 with minimal statistical assumptions from ecological data with missing values.", "output": [ "method" ] }, { "id": "task1163-49038a917887447993f636174b726100", "input": "The GP1 subunit of the surface glycoprotein ( GP ) mediates cell attachment through transferrin receptor 1 ( TfR1 ).", "output": [ "background" ] }, { "id": "task1163-15fe8dc77e0542b09018191997098bce", "input": "however , new technology using gel diluents has entered the US market.", "output": [ "background" ] }, { "id": "task1163-af150a8091e048a9a712f3c362d1176f", "input": "The SARS-CoV spike ( S ) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion.", "output": [ "background" ] }, { "id": "task1163-b8bbb1b17a4f429d9b2cf271b0e3b31d", "input": "Conclusion/Significance : Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.", "output": [ "finding" ] }, { "id": "task1163-1ed89e6826424cb1a03842026172b983", "input": "the first cases of pandemic ( H1N1 ) -2009 influenza ( H1N1sw ) virus were detected in France.", "output": [ "background" ] }, { "id": "task1163-11a558f74e594cab9e4fe0371e033ad2", "input": "Objective evidence of an immune response to allergens is generally not present until after 2 years of age.", "output": [ "finding" ] }, { "id": "task1163-4355524dcca2492ab1a25adfac3cf15d", "input": "A new coronavirus ( CoV ) identified as COVID-19 virus is the etiological agent responsible 31 for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan 1-4.", "output": [ "background" ] }, { "id": "task1163-9e11cb887a424c219b62e02dab5ec042", "input": "A mathematical model was used to estimate the relative change of incidence among provinces and age groups.", "output": [ "method" ] }, { "id": "task1163-b8d34b3a75364297ad6320c9e6a3be4b", "input": "Moreover , trends and perspectives for future investigation of this plant are discussed.", "output": [ "purpose" ] }, { "id": "task1163-329af456e59e49a385eda911cbf76a21", "input": "Mutian X given orally cleared the virus in 29 cats ; although four cats required a repeated course to finally stop virus shedding.", "output": [ "finding" ] }, { "id": "task1163-9c5a2cf9ad7043438d136d575e3f69cf", "input": "and on symptoms of post-traumatic stress disorder ( PTSD ) and depression.", "output": [ "method" ] }, { "id": "task1163-6ce4260bc9794200807348bed1fc08ce", "input": "2.976 and 0.362 Mbps , which were separated by an ancient chromosome break ( 55-80 MYA ) and followed by a chromosomal inversion were annotated in detail.", "output": [ "background" ] }, { "id": "task1163-839a943b634c41bcbb887ca2b43435fc", "input": "The effects of two recent crises created by unusual viral infections of the respiratory tract - the severe acute respiratory syndrome ( SARS ) epidemic caused by the novel SARS coronavirus ( 4 , 5 ) and the bird flu ( 6 ) highlight the importance of research into ARDS.", "output": [ "background" ] }, { "id": "task1163-23dda52700a14192b31eb86b124373b6", "input": "For coronaviruses , these organelles take the form of double-membrane vesicles ( DMVs ) interconnected by a convoluted membrane network.", "output": [ "background" ] }, { "id": "task1163-a0c2847a7a7b42069309d90487b97a84", "input": "an aspect which is underexplored in the literature.", "output": [ "purpose" ] }, { "id": "task1163-e3f96ccaa11740538e1dacee72b2f003", "input": "treatment processes , and clinical outcomes were collected.", "output": [ "method" ] }, { "id": "task1163-df6365ccff0c4bed8df4ed1f6c3c95f2", "input": "The present study would help us better understand the dimerizationactivity relationship of SARS-CoV 3CL pro and afford potential information for designing anti-viral compounds targeting the dimer interface of the protease.", "output": [ "finding" ] }, { "id": "task1163-c7e58073e8174520bb9af3f7226b6d9f", "input": "of which human immunodeficiency virus ( HIV ) and influenza virus fusion proteins are members.", "output": [ "background" ] }, { "id": "task1163-a672b71d6b93422dab6cf9c4cc0e4d21", "input": "suggesting that pre-existing biosecurity measurements could not keep up with the rate of livestock intensification ( 16 ).", "output": [ "finding" ] }, { "id": "task1163-71bf18804ef54940b927a178b59a8059", "input": "In contrast , the lowest lymphocyte count and the ratio of PaO 2 to the fraction of inspired oxygen were lower in the SARS group.", "output": [ "finding" ] }, { "id": "task1163-969c5c952d934fe8910acb1e08f68f37", "input": "Rather , our data indicate that viral mutation rates have evolved to be higher as a result of selection for viruses with faster replication kinetics.", "output": [ "finding" ] }, { "id": "task1163-eca0f97b6a5540b48b0824aa6fd14df0", "input": "which subsequently initiates downstream signaling to induce interferon-αβ ( IFNαβ ) production.", "output": [ "background" ] }, { "id": "task1163-04d35d92ac1d48018566ac2f9d195b93", "input": "allowing more time for preening and ingestion of oocysts.", "output": [ "background" ] }, { "id": "task1163-9d5e513ee7494c53811990fe1981cd32", "input": "chemokines and type I interferon.", "output": [ "finding" ] }, { "id": "task1163-b4896ab5bad249829b6c81878ce663d9", "input": "Attempts were made to grow certain viruses in organ cultures of Fallopian tube.", "output": [ "method" ] }, { "id": "task1163-b5b865843175423a8dc5f32c06caf2c8", "input": "which can also arise through simple mutations.", "output": [ "finding" ] }, { "id": "task1163-739c4bf6cf5a4787983054ff024e54b0", "input": "Con A supernatants of bovine peripheral blood lymphocytes ( bConA sup ) and recombinant human IL-2 ( rhIL-2 ) , were also assessed.", "output": [ "method" ] }, { "id": "task1163-be790e797ea044d5a154d0cb0384962f", "input": "the patients were divided into a survival group ( n = 26 ) and a fatality group ( n = 8 ).", "output": [ "method" ] }, { "id": "task1163-b556122037b04b858c09a4af545e48d7", "input": "dynein heavy chain , fatty acid synthase and transmembrane protein 43 bound E protein.", "output": [ "method" ] }, { "id": "task1163-8ba946f7f6474eea9617cb142bbe43bf", "input": "such as development of MERS-like symptoms or exposure to patients.", "output": [ "purpose" ] }, { "id": "task1163-9964738ff859422fa077366b07160eae", "input": "influenza A and B , and parainfluenza virus 1-3.", "output": [ "method" ] }, { "id": "task1163-04399ae25bb5439d89cb2e75a64b5857", "input": "by determining crystal structures of prefusion RSV F bound to neutralizing human-derived antibodies AM22 and RSD5.", "output": [ "method" ] }, { "id": "task1163-44c4ac9eb5f74ff9ab08b30c55ba3ab1", "input": "Mucosal ulcerations , hemorrhage , and thrombosis occur early , followed by inflammatory changes.", "output": [ "background" ] }, { "id": "task1163-68e2c1b455fc4f3a832f2e0eb20042e7", "input": "increased risk of infection of LBW as compared to NBW newborns may reflect impairments in innate immunity.", "output": [ "background" ] }, { "id": "task1163-f6d05429a3c943e99dd9b4078e11f124", "input": "and air trapping ( 3 % ).", "output": [ "finding" ] }, { "id": "task1163-2853960fd926468594caac4ec2c3de0f", "input": "Here we computed the number of excess cases by region and found correlation with the number of reported COVID19 cases so far.", "output": [ "purpose" ] }, { "id": "task1163-b2f1156ebd7049c48625367e3c2a1a15", "input": "Herein , we describe the recent progress that has been made on characterizing these large RNAs and provide brief descriptions of the techniques that will be at the forefront of future advances.", "output": [ "purpose" ] }, { "id": "task1163-3da4881e82dc4a94ad2c9f4531cb7b47", "input": "the virus family responsible for the most serious form of URI.", "output": [ "purpose" ] }, { "id": "task1163-6ae40e383ef94ddb828cfcb4aef85b5d", "input": "Preferred mixing captures as a good approximation the assortativity of a heterogeneously mixing population.", "output": [ "method" ] }, { "id": "task1163-0f1c6bb96e694988acfb1aaf0995d493", "input": "Bovine coronavirus ( BCoV ) is an economically signifi cant cause of enteric and respiratory diseases in cattle throughout the world.", "output": [ "background" ] }, { "id": "task1163-4cde6df25e9d4b0b8aa512c6049a9e52", "input": "risk factors , mental health interventions , and its impact.", "output": [ "method" ] }, { "id": "task1163-acacb8e7f7a74cc49d7cd323476bf3d9", "input": "The obtained sequences were verified by basic local alignment search tool.", "output": [ "method" ] }, { "id": "task1163-0d049633d517413aa1a9e17278bc279f", "input": "The present study examined whether the genome-length negative-strand RNA serves as a template for subgenomic mRNA synthesis.", "output": [ "purpose" ] }, { "id": "task1163-ce00c619d40647aeb9d8737efb61961f", "input": "Data was analyzed from PBS-injected Trpv1-Dtr mice ( n = 3 ) or DTinjected Trpv1-Dtr mice ( n = 3 ).", "output": [ "method" ] }, { "id": "task1163-f926e35d230b4c0daf2373dc39dc7a83", "input": "This study used SARIMAX / ( E ) GARCH volatility models to forecast visitor arrivals by air transport to New Zealand from its eight key tourist source markets the United Kingdom ( UK ) and the United States ( US ) ) and control macroeconomic factors together with global and regional structural changes.", "output": [ "purpose" ] }, { "id": "task1163-081726a10ab2473da98e9dc78a93cbcb", "input": "Here , we characterized this process relative to ( 1 ) specific 18S and 28S ribosomal RNA cleavage sites and ( 2 ) identity of specific upstream signaling elements in this pathway.", "output": [ "background" ] }, { "id": "task1163-53feda86ff7c46958564e21d494f8be6", "input": "Our aim was to generate immunization antibodies equivalent to those seen in plasma.", "output": [ "purpose" ] }, { "id": "task1163-d383e94add724704bc6b204b75815b40", "input": "aminosides , macrolides , quinolones , and cotrimoxazole.", "output": [ "finding" ] }, { "id": "task1163-9301c1e7ffab4594bcf4f29ae66d38c8", "input": "medical inspection , self-declaration , and reporting by on-board staff.", "output": [ "method" ] }, { "id": "task1163-e6f424ce52f04d8eb06a0bca1d020b10", "input": "Children aged 48-96 months were followed longitudinally for 1 year.", "output": [ "method" ] }, { "id": "task1163-165bb56db2464a83abf4be1b832b09f0", "input": "Animals were fixed 1 day to 4 weeks later and the spinal cords were examined by light and electron microscopy.", "output": [ "background" ] }, { "id": "task1163-f5a649a67e8a478e80a5113810d06a86", "input": "such as autoimmune and metabolic disorders.", "output": [ "background" ] }, { "id": "task1163-fe4fe2518def4e56911dc0da62630b8a", "input": "Random amplification of partially purified vitreous fluid ( VF ) - derived nucleic acid revealed the presence of human anelloviruses in VF of SHAPU patients.", "output": [ "background" ] }, { "id": "task1163-8160fb896e994922af0cabf97356a35b", "input": "were introduced into a prokaryotic expression vector pET32 to express recombinant PoIFN - ␥ - W ( rPoIFN - ␥ - W ) and rPoIFN - ␥ - M protein variants in Escherichia coli.", "output": [ "method" ] }, { "id": "task1163-e76a850703c042b4803a04546a6ac673", "input": "Transchromosomic bovines ( Tc-bovines ) adaptively produce fully human polyclonal immunoglobulin ( Ig ) G antibodies after exposure to immunogenic antigen ( s ).", "output": [ "background" ] }, { "id": "task1163-e6dd222fafb04754b0b808560b4b9c2b", "input": "Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study.", "output": [ "method" ] }, { "id": "task1163-91dca5dfb2be4823a4db6ff1350cea20", "input": "however initial chest CT were positive in only half patients.", "output": [ "finding" ] }, { "id": "task1163-50909cb048a54ca08117d2a5eeb7a76c", "input": "but limited other clinical signs of disease.", "output": [ "finding" ] }, { "id": "task1163-e356af8e206545179dd5a01855f72fe5", "input": "There was no significant impact on commonly measured endpoints in HSD rats and B6C3F1/N mice given enrichment devices.", "output": [ "finding" ] }, { "id": "task1163-766d86e704db4674873670e7a2d952c0", "input": "A last point of attention is the prevention of attracting wild life zoonoses via dogs to family members ( eg.", "output": [ "finding" ] }, { "id": "task1163-83fb94601b054725ae91dc2d991752b1", "input": "it is not surprising that the rocaglate Silvestrol has broad-spectrum antiviral activity.", "output": [ "background" ] }, { "id": "task1163-1993ea681950423d8ee7f8399f670b45", "input": "QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial ( antibacterial and antifungal ) activity over the one-target QSAR models.", "output": [ "finding" ] }, { "id": "task1163-3ce7f4963c9042bd889f368b813a3dc6", "input": "These results should guide future vaccine-design efforts and help elucidate the mechanisms of RSV F triggering and fusion.", "output": [ "finding" ] }, { "id": "task1163-702f022c409a44e29567efb8eb931824", "input": "we investigated DendoU in vivo activity.", "output": [ "method" ] }, { "id": "task1163-0773abc0b62f46e5942a6cf697c84073", "input": "and the expression of M fusion protein was induced by using isopropylthio-beta-D-galactoside ( IPTG ) as inducer.", "output": [ "method" ] }, { "id": "task1163-d724b6e956604f3984179abcecb5a238", "input": "Clinical information was retrospectively collected.", "output": [ "method" ] }, { "id": "task1163-d82c65621a2146b99dc4c9ae7548b020", "input": "and increasing transmission before symptoms.", "output": [ "finding" ] }, { "id": "task1163-8365204428bc4871990464faae59f701", "input": "Methods The study was cross-sectional with prospective sample collection.", "output": [ "method" ] }, { "id": "task1163-b28a79f53ffc4f7abbf20663c67c8020", "input": "In the current study , two recombinant baculovirus were generated to express the spike ( S ) protein of SARS-like coronavirus ( SL-CoV ) isolated from bats ( vAcBS ) and the envelope ( E ) and membrane ( M ) proteins of SARS-CoV , respectively.", "output": [ "purpose" ] }, { "id": "task1163-acb3e6be39f14058a523b44b0887f0d0", "input": "pleural effusion , and ground-glass nodules were also seen.", "output": [ "finding" ] }, { "id": "task1163-7213f55c24964352b1d35a1403912fd2", "input": "In this study , infrared thermography ( IRT ) was assessed as a means of detecting foot-and-mouth disease virus ( FMDV ) - infected cattle before and after the development of clinical signs.", "output": [ "purpose" ] }, { "id": "task1163-e20478b97cb04d2086d890169feb1901", "input": "Cytotoxicity was assessed by MTT-reduction assay.", "output": [ "method" ] }, { "id": "task1163-40b943da2d264c2183f6d23acf310f84", "input": "In this review , we focus on the urgent need and current efforts in HEV drug development.", "output": [ "purpose" ] }, { "id": "task1163-9477736f6ef34a258de5db5d600cace5", "input": "IL-6 , IL-10 , IL-12 p40 and TNF-a by real-time PCR.", "output": [ "method" ] }, { "id": "task1163-562cc0ca8c1849d9a8b583de1bee3af1", "input": "In this study , we looked at thousands of infected cells and identified two coronavirus mutants that made half as many organelles as normal and two others that made typical numbers but smaller organelles.", "output": [ "finding" ] }, { "id": "task1163-c093003f577f4e52b2c4a656a5daffb3", "input": "We provide guidance to help understand and advance the search for a cure.", "output": [ "purpose" ] }, { "id": "task1163-ea264492b78a453badbdbfce6d0a4b88", "input": "GPs in Indonesia completed an online-based survey.", "output": [ "method" ] }, { "id": "task1163-5ea9196ba9cf41f69c251658b8a36d35", "input": "functions , genetics , disease associations and therapeutic implications of CR1.", "output": [ "purpose" ] }, { "id": "task1163-a05097d9675544b2a70de59d76a8a1e2", "input": "an impervious disposable gown , and a cotton nondisposable gown , was investigated.", "output": [ "method" ] }, { "id": "task1163-71919ee19fa9445ba0f36d2695149d50", "input": "Five state of the art heart rate measuring methods were re-implemented and tested with the feasibility study database.", "output": [ "method" ] }, { "id": "task1163-8afe9e37f7b3486fa5275613daa2fc35", "input": "and public health or government offi cials.", "output": [ "purpose" ] }, { "id": "task1163-d57e13b14b2440409a034db6dcd00325", "input": "including extremely potent antibodies that PLOS Pathogens | https://doi.recognize prefusion-specific epitopes.", "output": [ "finding" ] }, { "id": "task1163-8ec2d3c78278417b9947d4da09a51a83", "input": "but not in unaffected family members.", "output": [ "finding" ] }, { "id": "task1163-b96a2da9bdd5485b8b6b53ca0f3f8731", "input": "The primary modes of transmission of severe acute respiratory syndrome ( SARS ) coronavirus ( SARS-CoV ) appear to be direct mucus membrane contact with infectious droplets and through exposure to formites.", "output": [ "background" ] }, { "id": "task1163-c52c2ad2e0dc4acba398a50acbbca1a3", "input": "Both viruses cause an ARDS-like picture.", "output": [ "background" ] }, { "id": "task1163-0656cf79a8da4af19c8e42cf9567e666", "input": "Periodic compilations of most cited articles may be useful for critical care practitioners and researches to keep abreast of important information.", "output": [ "finding" ] }, { "id": "task1163-f777b421ffab486a88c7c6ca029db6b5", "input": "we asked why RNA viruses have n't evolved a polymerase with a lower mutation rate.", "output": [ "purpose" ] }, { "id": "task1163-46811821cdcf4ad8afab37711d272f2a", "input": "Four naïve calves were commingled with a group of six naturally infected calves and sequentially euthanized.", "output": [ "method" ] }, { "id": "task1163-309c11e5cc944223a873ca8ddb42b3fa", "input": "Methods-All lung transplant cases between January 2000 and July 2013 performed at our center were reviewed for respiratory viral samples.", "output": [ "method" ] }, { "id": "task1163-18dfe801f71441d0b44a040cc0c28373", "input": "which converts standard nucleotides in a target to AEGIS nucleotides in a product , improving hybridization.", "output": [ "method" ] }, { "id": "task1163-c6b4d8a5609a40528f03009f2d3781df", "input": "pathophysiology , diagnosis , prognosis and therapy of such diseases.", "output": [ "background" ] }, { "id": "task1163-a5fc989bceeb47c290e0e50aad6db656", "input": "Two additional specific programs are devised to calculate the psychrometrics and the thermodynamic properties of the refrigerant R134a.", "output": [ "method" ] }, { "id": "task1163-f1423851d8a84147a4f86add7894fc10", "input": "without a particular geographical distribution pattern.", "output": [ "finding" ] }, { "id": "task1163-618c7162aa7645728e3f5cbe1c43b44c", "input": "a disease associated with infection with a mutated form of FCoV.", "output": [ "purpose" ] }, { "id": "task1163-21a5e3557ee94fb39949749f58629686", "input": "not because they facilitate adaptation but because it is hard to be both fast and accurate and these viruses have prioritized speed over fidelity.", "output": [ "finding" ] }, { "id": "task1163-df6552c78179408fada94b4e5330c188", "input": "Objectives : To improve our understanding of the global epidemiology of common respiratory viruses by analysing their contemporaneous incidence at multiple sites.", "output": [ "purpose" ] }, { "id": "task1163-fdf22adea44c48dc9f28ea33e776f681", "input": "There were significant increases in non-fracture injuries.", "output": [ "finding" ] }, { "id": "task1163-8d8b5521663d451281293039dbfa6f6c", "input": "which preferred to end with A or T.", "output": [ "finding" ] }, { "id": "task1163-3da1fa6df9214e61b9ed373302efb8d5", "input": "We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin ( NGAL ) and estimated glomerular filtration rates ( eGFR ) in septic patients.", "output": [ "purpose" ] }, { "id": "task1163-1b2a94b037144f7cbe1abc77b6d6820d", "input": "and B6C3F1/N mice were assigned to control ( unenriched ) and enriched experimental groups.", "output": [ "method" ] }, { "id": "task1163-1554ac8c2d194acb8458f2729a4d3288", "input": "Current antibody drugs have increasingly fewer adverse effects due to their high specificity.", "output": [ "background" ] }, { "id": "task1163-7ffbcb1abebd4c2e8e4b46bcfc81ac80", "input": "( i ) Nasal swabs were tested using rapid influenza diagnostic test ( RIDT ) and two RT-PCR assays.", "output": [ "method" ] }, { "id": "task1163-c7c02ded0d394072b8a7c9366bffd489", "input": "and updated periodically with new probabilities every three months.", "output": [ "method" ] }, { "id": "task1163-34079a9ab99b4eee8059e978659409d5", "input": "disinfected and then homogenized for testing.", "output": [ "method" ] }, { "id": "task1163-f869e07cf33543dab1bc9580446956d0", "input": "The ellagitannin Lagerstroemin was identified as an effective component of the banaba extract responsible for the activity.", "output": [ "background" ] }, { "id": "task1163-0262a71cff59453eb86124c33cf99d5a", "input": "Postweaning average daily gain and carcass characteristics were similar for ACD and RES calves.", "output": [ "finding" ] }, { "id": "task1163-49e2f713e4524009acd5964ccb329c21", "input": "Here we describe a new concept using combinatorial self-assembly of DNA nanotiles into micrometer-sized two-dimensional arrays that carry nucleic acid probes and barcoded fluorescent dyes to achieve multiplexed detection.", "output": [ "purpose" ] }, { "id": "task1163-f5620f6cdace466495d4ae0909dd1b41", "input": "but not the protective antiviral responses.", "output": [ "finding" ] }, { "id": "task1163-00644111feeb4d08a18d0ffcdafecd8e", "input": "no virus particles were detected.", "output": [ "finding" ] }, { "id": "task1163-fa5a6ed9b443497e9bee9049be0c5eac", "input": "the USA , and Asia in people who travelled from the Middle East or their contacts.", "output": [ "background" ] }, { "id": "task1163-53015e0315ed4b23afbce6be4387c7d1", "input": "All seem to use a copy-choice template switching action for recombination.", "output": [ "finding" ] }, { "id": "task1163-c2053db1543d403b931f5c6022b4f75c", "input": "Methods We actively surveyed arriving travellers at all 272 international entry-exit ports in mainland China.", "output": [ "method" ] }, { "id": "task1163-7d60e2d7c04c4c1c8fb8c674ed2c6ccc", "input": "In 2006 assays for respiratory picornaviruses and hMPV were added.", "output": [ "method" ] }, { "id": "task1163-572184f0b0704709b855693e630b3542", "input": "We developed a novel concept that allows to considerably improve the performance of conventionally used ÿltering-facepiece respirators against ÿne and ultraÿne aerosols including airborne viral and bacterial agents.", "output": [ "purpose" ] }, { "id": "task1163-2ca85a56299a4cbc8e9e37bb86bbdb3c", "input": "The National Interagency Confederation for Biological Research and collaborators rapidly produced and then evaluated anti-Ebola virus IgG immunoglobulins ( collectively termed SAB-139 ) purified from Tc-bovine plasma after sequential hyperimmunization with an Ebola virus Makona isolate glycoprotein nanoparticle vaccine.", "output": [ "background" ] }, { "id": "task1163-314176b37f274a819279235afb005be4", "input": "In this study , we report the complete genome sequence of two contemporary human coronavirus OC43 ( HCoV-OC43 ) strains detected in 2003 and 2004 , respectively.", "output": [ "purpose" ] }, { "id": "task1163-5801a9511f2548f6ba80f1bc0ed93ba8", "input": "Escherichia coli strain DH5α was used to amplify plasmid DNA.", "output": [ "method" ] }, { "id": "task1163-6b4d391a3e804f7dbbc6fac75b141ea3", "input": "our findings indicate the potential of COVID-19 to cause greater outbreak on the ship.", "output": [ "finding" ] }, { "id": "task1163-d74e7d398d6346dba96e9ce3c903f102", "input": "In the present study , we used the idea of adaptive memory to understand whether human memory evolved to recall information about medicinal plants for the treatment of serious diseases.", "output": [ "purpose" ] }, { "id": "task1163-ead65982f93249c2ad93a8e503f658b0", "input": "Multivariate Cox modeling was employed to assess the impact of CARV isolation on progression to CLAD and graft loss.", "output": [ "method" ] }, { "id": "task1163-446e79d2ae7c4dbc9df640e647270a13", "input": "and ( iii ) the use of bispecific adapters to mediate targeting of a virus to a specified moiety on a tumor cell.", "output": [ "method" ] }, { "id": "task1163-ede2032ddec2491da6fabb57da5ad70b", "input": "parainfluenza virus type 3 and cytomegalovirus.", "output": [ "purpose" ] }, { "id": "task1163-74242f0a97a045799f91a2b198de78fd", "input": "However , little is known about JNK1/2 and p38 MAPK signaling pathways in enterovirus 71 ( EV71 ) - infected immature dendritic cells ( iDCs ).", "output": [ "background" ] }, { "id": "task1163-100ce20b490f4d4b978d19714a5e3fec", "input": "focusing on the targeted , self-assembled nanoparticles which show potential to become a useful and efficient tool in cancer therapy.", "output": [ "purpose" ] }, { "id": "task1163-1f14c1ce790442e88db739dcf19f198e", "input": "the full spectrum of cases is described.", "output": [ "method" ] }, { "id": "task1163-1e17372ac91c4c9fa38b4aabdec3a78d", "input": "and 13 C-Met labeling was performed to quickly assess cruzain-ligand interactions for a set of eight low molecular weight compounds exhibiting micromolar binding or inhibition.", "output": [ "method" ] }, { "id": "task1163-c155352764d94064b5d6e83187d8035a", "input": "We conducted an investigation of healthcare workers exposed to laboratory-confirmed SARS patients in the United States to evaluate infection-control practices and possible SARSassociated coronavirus ( SARS-CoV ) transmission.", "output": [ "purpose" ] }, { "id": "task1163-8ccfc8ab04304f2390444f3bfc5ab0d6", "input": "In this study , we further examined the relationship between Tat and Egr-1 in astrocytes.", "output": [ "purpose" ] }, { "id": "task1163-94d24ed3d2de4dd087f271252d199500", "input": "hospital with pneumonia had evidence of recent B. pertussis infection.", "output": [ "background" ] }, { "id": "task1163-e0fbcff211c3479fa71f9a40cd2dd946", "input": "The cleavage mechanism of severe acute respiratory syndrome ( SARS ) coronavirus main proteinase ( M pro or 3CL pro ) for the octapeptide AVLQSGFR is studied using molecular mechanics ( MM ) and quantum mechanics ( QM ).", "output": [ "background" ] }, { "id": "task1163-7e8d0aa964104ded90bc7869c9a572ea", "input": "encoding thioredoxin interacting protein ( TXNIP ).", "output": [ "background" ] }, { "id": "task1163-59a7cf0c316f4017a67a8352697ac4a5", "input": "A substantial proportion of hitherto unexplained respiratory tract illnesses is associated with human metapneumovirus ( hMPV ) infection.", "output": [ "background" ] }, { "id": "task1163-5e261980ca044ebf94d456f88a30898f", "input": "and the factors influencing their use of these protective practices.", "output": [ "purpose" ] }, { "id": "task1163-ee24ab57ca7542ee95b05ba9d0e06232", "input": "comparable endpoint titers , and similar focus staining.", "output": [ "method" ] }, { "id": "task1163-c3b894f2c2de40f3bf9be0c9f3c5383d", "input": "Finally , the biosafety measures required to protect researchers and clinical lab workers are considered.", "output": [ "purpose" ] }, { "id": "task1163-4982957cf457442c9c368c813be239c8", "input": "We describe the isolation , biological and genetic characterization of a host-range variant of bovine coronavirus ( BCoV ) detected in water buffalo ( Bubalus bubalis ).", "output": [ "purpose" ] }, { "id": "task1163-56e53945b2e141bd86684e106d8eefed", "input": "Of great value is information provided by ESCCAP ( www.esccap.org ) with information for European countries ( veterinarians and pet-owners ) on prevalences and prevention of parasitic infections in dogs and cats in the major languages of Europe.", "output": [ "background" ] }, { "id": "task1163-df96256ed7654605b2cbc0929a2ba745", "input": "At present , it is of utmost 31 importance to understand the virus biology and to rapidly assess the potential of existing drugs 32 and develop new active compounds.", "output": [ "background" ] }, { "id": "task1163-b29f913383ab459db1a1799af57dd1e3", "input": "are present in milk and colostrum of all lactating species.", "output": [ "background" ] }, { "id": "task1163-1016458a12494c0e957f361b08b26a84", "input": "while maintaining the attenuated phenotype.", "output": [ "background" ] }, { "id": "task1163-1ec2e8aa75fe4cf9bcf2df7f656bec80", "input": "Coccidiosis is an economically significant disease of poultry caused by species of Eimeria , a parasitic protozoan.", "output": [ "background" ] }, { "id": "task1163-895a354a30a9416488f97028239998ff", "input": "Vitamin D 3 treatment was associated with a significantly lower risk for laboratory confirmed URTI ( RR : 0.54 , CI 95 : 0.34-0.84 , p = 0.007 ) and with a significantly lower mean viral load measured as log 10 viral copies/mL ( mean difference : − 0.89 , CI 95 : -1.7 , − 0.06 , p = 0.04 ).", "output": [ "finding" ] }, { "id": "task1163-84e6aabf619b4877a67953dc81bd6dd5", "input": "with high rates of seroprotection ( ≥ 40 HAI titer ) in 82-92 % of all subjects and in 64-85 % of subjects who were seronegative at the time of immunization.", "output": [ "finding" ] }, { "id": "task1163-55a92c06a3cb46879963b2b4eb66c99b", "input": "Here we present a metapopulation model of disease spread in Great Britain defined at the level of electoral wards.", "output": [ "purpose" ] }, { "id": "task1163-f00f484b33a8495ea4808da40ee1a7ce", "input": "This study aims to systematically review the literature to appraise and synthesise scientific research papers that concern incentives that have been tested to increase data sharing in health and medical research.", "output": [ "purpose" ] }, { "id": "task1163-01f5ab4e3a404a0ea35fcd36c0a9fd4c", "input": "nasopharyngeal aspirates were taken from children with different viral loads and a combined high throughput RNAseq and label free quantitative proteomics approach was used to characterize the nucleic acid and proteins in these samples.", "output": [ "method" ] }, { "id": "task1163-62386866698d43be93d6f46cbb2b4cd7", "input": "High-throughput sequencing ( HTS ) is becoming the state-of-the-art technology for typing of microbial isolates , especially in clinical samples.", "output": [ "background" ] }, { "id": "task1163-a197d0db4c2348e9a914531fd969102b", "input": "there are not many methods for prediction of pseudoknotted structures that can incorporate structural information as input.", "output": [ "background" ] }, { "id": "task1163-a8c4517fe6034724a02b1b6253318b67", "input": "Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients.", "output": [ "finding" ] }, { "id": "task1163-5e14c0c94b56409e87000d6bf6f63f52", "input": "Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats.", "output": [ "method" ] }, { "id": "task1163-4659db2e99a34f46a82d73910f2d9278", "input": "it is necessary to have a deep understanding of mucosal immunology and to test various mucosal vaccination strategies.", "output": [ "purpose" ] }, { "id": "task1163-7d935fcbb459402a8693c1a985b5cdba", "input": "the system classifies alerts by location and disease and then overlays them on an interactive geographic map.", "output": [ "method" ] }, { "id": "task1163-c2b1902f9c634523834c76c309bed5c5", "input": "Objectives This study was conducted to identify whether these viruses were associated with ARTI among children B5 years of age in rural and peri-urban populations in South India.", "output": [ "purpose" ] }, { "id": "task1163-a48dcb15dcad4ea58136389590cf6fde", "input": "Objectives : The purpose of this study was to investigate factors influencing preventive behavior against MERS-CoV among Korean nursing students.", "output": [ "purpose" ] }, { "id": "task1163-474043371869433aa8d7a3007d917240", "input": "Mucosal vaccination offers great advantage for inducing protective immune response to prevent viral transmission and dissemination.", "output": [ "background" ] }, { "id": "task1163-d7a5a4417997495eade03659d57e468b", "input": "tiny , partially doublestranded , reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames.", "output": [ "background" ] }, { "id": "task1163-d8254643a4174179805821530033d62f", "input": "BMI , diabetes , and hypercholesterolemia with mild flu in an Iranian population.", "output": [ "purpose" ] }, { "id": "task1163-a56a22720ee44b56bc994847bb0e27c3", "input": "Mafa-B , Mafa-DQB1 , and Mafa-DRB alleles were characterized and their combinations were investigated from 30 macaques of Vietnamese origin by cloning and sequencing.", "output": [ "method" ] }, { "id": "task1163-84595906f1924f41bed1cbfad14dbee3", "input": "immunocompromised patients experience much higher rates ( 4-10 % ) ( 6 ).", "output": [ "background" ] }, { "id": "task1163-dea262abf5d74ce6ba310d1097c36e9e", "input": "In this paper , we show our lab tested solutions in two specific healthcare scenarios.", "output": [ "purpose" ] }, { "id": "task1163-d5ce9c12e26f4bd4b7ecc1aa6f1bd8c7", "input": "for the development of a MS-like disease is explored.", "output": [ "method" ] }, { "id": "task1163-c7c4455b962349df930756db6de9d6fb", "input": "formulae derived in order to convert antibody levels as determined by one immunological method to that of another.", "output": [ "finding" ] }, { "id": "task1163-07e37d0f55e0432ca538ce416ff5505e", "input": "We expressed dCAT-1 or mCAT-1 of NIH 3T3 origin in cells that are not normally infectible with ecotropic MLVs and evaluated the transfectants for susceptibility to virus infection and to virus-induced syncytium formation.", "output": [ "method" ] }, { "id": "task1163-b07681de4dcc474ba0fcd39f4939c280", "input": "It begins with an overall introduction of the fabrication followed by an in-depth review on the detection techniques in such devices and various applications with respect to effort and performance to date.", "output": [ "method" ] }, { "id": "task1163-725485a9befc44938e01866eb76b159f", "input": "to be relentlessly shaped throughout the history of our species.", "output": [ "background" ] }, { "id": "task1163-fe8e92bdec9e4f4ebdd4e570a1631f6a", "input": "However no such work was conducted in Cambodia or Lao PDR.", "output": [ "background" ] }, { "id": "task1163-7f8b50d3b142428889e93d228eb5fb49", "input": "This research explores perceived importance of safety and security measures from the perspectives of tourists and service providers.", "output": [ "purpose" ] }, { "id": "task1163-5ae1a497c1b4410c875f17e7a2e0f518", "input": "the largest thoroughbred horse breeding region in Japan , between 2012 and 2014.", "output": [ "method" ] }, { "id": "task1163-bda40614f66d40b3a184905da5c58298", "input": "Conclusion : The median with 95 % CI of R0 of COVID-19 was about 2.28 ( 2.06-2.52 ) during the early stage experienced on the Diamond Princess cruise ship.", "output": [ "finding" ] }, { "id": "task1163-208a189ce45243b5ba7440cf7e464ece", "input": "Medline , EMBASE , SCOPUS and CINAHL.", "output": [ "method" ] }, { "id": "task1163-19f3afed97da482ca4f01b21fec7796b", "input": "Untargeted metabolomic analyses based on mass spectrometry were performed on urine samples collected from infants with acute bronchiolitis.", "output": [ "method" ] }, { "id": "task1163-b5daa019f616460dace561813ad586ae", "input": "there can be severe outcomes , including heart inflammation.", "output": [ "background" ] }, { "id": "task1163-43acbd7dbffe4ab189b8c72d5eeb1b17", "input": "blood vessels , and neural regulation of autonomic and cardiovascular modulation.", "output": [ "purpose" ] }, { "id": "task1163-0f86f27eedff4bf0b7957c0b0a95dd0f", "input": "exhibits potent antiviral activity against FIV.", "output": [ "background" ] }, { "id": "task1163-fa707032abc349abb5239ed1326526ef", "input": "version 3.69 , was used to estimate immunoglobulin phylogenies from nucleotide sequences that were first aligned using ClustalW2 , as previously described12.", "output": [ "method" ] }, { "id": "task1163-3bb48c443cea4df99c746ee485161b1c", "input": "Research efforts have focused on innovations that will reduce the morbidity associated with AECB.", "output": [ "background" ] }, { "id": "task1163-a9353d6465b84da9a5ba7b9a64aa54d9", "input": "microglia , astrocytes and neurons in the central nervous system.", "output": [ "background" ] }, { "id": "task1163-174c09fb9de84ee2969316c1608751ac", "input": "while the least stable genes failed to do so.", "output": [ "finding" ] }, { "id": "task1163-0732b1ac8d6a425ab05329f5d85692d6", "input": "which is to encapsidate the viral genome.", "output": [ "background" ] }, { "id": "task1163-26cda24ac9904b53aec19bf86f9a36c4", "input": "Seven residues on the dimer interface were selected for evaluating their contributions to dimer stability and catalytic activity by biophysical and biochemical methods.", "output": [ "method" ] }, { "id": "task1163-9a82add66b1949dabf79a2f83b1d5221", "input": "The genome included at a minimum of 11 predicted open reading frames ( ORFs ) flanked by 5 ′ and 3 ′ untranslated regions ( UTR ) of 211 and 289 nucleotides.", "output": [ "method" ] }, { "id": "task1163-5338cbe7a5aa4051a456cfb34d222b18", "input": "Mice ( 20 per group ) were vaccinated i.m. with either PBS + alum or 2-valent ( HRV-16 and HRV-76 ) inactivated HRV + alum in order to establish pre-existing immunity to types 16 and 76 in one group.", "output": [ "method" ] }, { "id": "task1163-76f20be215184716b295e7d6f9225f0e", "input": "Using siRNA , we further showed that p300 regulated both constitutive and Tat-mediated GFAP expression.", "output": [ "finding" ] }, { "id": "task1163-c3e78df104344c3f8e2b991e3d12a00c", "input": "Neutralization assay results indicated that the infectivity of EV71 and CVA16 strains in RD cells was cross-blocked by IgY in a dose-dependent manner.", "output": [ "finding" ] }, { "id": "task1163-b10994eff76d4051a6950177c17346e5", "input": "In this study , we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis.", "output": [ "purpose" ] }, { "id": "task1163-fa3ea0767aa24f6e90d04e152dc441dd", "input": "This chapter will summarize the current body of literature related to NMs and viral exposures with a primary focus on immune modulation.", "output": [ "purpose" ] }, { "id": "task1163-36eec39f81894b5a9a90604a5dd5bed3", "input": "a disproportionate number of sRNAs ( ,30 % ) were located in genomic region unique to strain 2336 ( ,18 % of the total genome ).", "output": [ "finding" ] }, { "id": "task1163-6529b8c4a9ad4c3e9f1b8da1e972ce2a", "input": "in addition to increased hospitalization costs.", "output": [ "background" ] }, { "id": "task1163-4e580ad2a2d6453789963323db5ddffc", "input": "lactoferrin as a treatment for calf diarrhea was not beneficial.", "output": [ "finding" ] }, { "id": "task1163-7d1d99b022584ee3aaf82a68d2d24973", "input": "A sectorial energy demand analysis and forecasting model was developed to analyze six Chinese provinces with different economic backgrounds.", "output": [ "purpose" ] }, { "id": "task1163-5283a4fc1a2e41e5af151997a20751c6", "input": "The aim of this study was to evaluate the cytotoxicity of Isatis indigotica extracts on human leukemia cell line ( HL-60 ) and the antiviral activity on swine pseudorabies virus ( PrV ) in in vitro assays.", "output": [ "purpose" ] }, { "id": "task1163-1ede8d53f2ff4a2fb6b06a214b980444", "input": "following vaccination , and as potential immunotherapeutic targets.", "output": [ "purpose" ] }, { "id": "task1163-b5e0bde71daa4fa9b2f416171d2b1706", "input": "which opens a new horizon in protein science for stability enhancement and function reinforcement via topology engineering.", "output": [ "finding" ] }, { "id": "task1163-4bc56dbbf79341d2aa2d318276879e81", "input": "endocytosis , intracellular trafficking , membrane fusion , and infection.", "output": [ "method" ] }, { "id": "task1163-f43e3ea629a64c36a7e3ff57a685ba33", "input": "Igs are divided into classes having different physico-chemical structures and biological activities.", "output": [ "background" ] }, { "id": "task1163-5ee4c0b2aba143f194626cf93dc9e0f5", "input": "facilitate attachment and entry into host cells.", "output": [ "finding" ] }, { "id": "task1163-3320a04535744ef3a9762a9c67f21083", "input": "All samples were selected and matched for age in these 2 groups.", "output": [ "method" ] }, { "id": "task1163-7e00192244dd4c0286804f9e65537611", "input": "We developed a probabilistic model and used parameters from a published model ( i.e. , InfluSim ) and travel data from Pacific Island Countries and Territories ( PICTs ).", "output": [ "method" ] }, { "id": "task1163-1b766ad21d904afcb848fb9aa244c8c3", "input": "Three days later , supernatants were harvested and subjected to virus titration.", "output": [ "method" ] }, { "id": "task1163-e442d1449411402fb76e129c0d70ebd8", "input": "This type of function can be used 42 to interpret the `` psychological effects '' ( 11 ).", "output": [ "method" ] }, { "id": "task1163-6b3faa4a0e9c4f45b0188d4d475f8717", "input": "exposure to HMPX information and knowledge on HMPX.", "output": [ "method" ] }, { "id": "task1163-a472c65ae379415b9b4117331a8f0ace", "input": "Therefore , the expressed fusion protein has a good antigenicity.", "output": [ "finding" ] }, { "id": "task1163-fd343d6afc4540618cdf133958a61909", "input": "Additionally , we discuss the question of where Ag presentation is initiated and under what conditions neuroantigens are made available to APCs with special emphasis on which cytokines may be important in this process.", "output": [ "finding" ] }, { "id": "task1163-c823ab7c784c4e3f9794fd8f0041b4b9", "input": "The methods used to study G-quadruplexes have been essential to the rapid progress in our understanding of this exciting nucleic acid secondary structure.", "output": [ "background" ] }, { "id": "task1163-8775cbff16ff4e7c97796827e1bb142b", "input": "In this study , a comparative analysis of the codon usage bias was performed in Aeropyrum pernix K1 and two other phylogenetically related Crenarchaeota microorganisms ( i.e. , Pyrobaculum aerophilum str.", "output": [ "purpose" ] }, { "id": "task1163-81044522489541da855cd37bfc3eaa4e", "input": "These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.", "output": [ "background" ] }, { "id": "task1163-37f6c02653824e99a8c19fa068c30f6d", "input": "One potential target for SARS-CoV antiviral drug development is the 3C-like protease ( 3CLpro ).", "output": [ "background" ] }, { "id": "task1163-e1a818741168465fb8520b8564d78ee3", "input": "Trump pushed an ambitious `` America first '' agenda aimed at transforming the US into a global energy superpower.", "output": [ "background" ] }, { "id": "task1163-c38c7b71ed004204988dce9f2025a423", "input": "surgical masks and homemade masks when worn during a variety of activities by healthy volunteers and a simulated patient.", "output": [ "method" ] }, { "id": "task1163-fd548722a2f0468ca67808dcb4b967cd", "input": "To a large extent , the immune correlates of protection against hantavirus are not known.", "output": [ "background" ] }, { "id": "task1163-099b2cf7f6e34492b87b6466bfbfc75b", "input": "and lactoferrin ( Lf ) in calves with an acute respiratory disease experimentally induced by Chlamydia ( C. ) psittaci.", "output": [ "purpose" ] }, { "id": "task1163-e45153ef847345e580b64045a874d159", "input": "The initial interaction between the vesicle and the target membrane has been referred to as tethering.", "output": [ "background" ] }, { "id": "task1163-1b49c54491d146628d8019d4e35d501a", "input": "serum , and tissue samples was used to characterize health status.", "output": [ "method" ] }, { "id": "task1163-447abf02ba6c4f55b6f53e0f3492e0f7", "input": "SCUB patterns were also associated with phylogenetic relationship among given species.", "output": [ "background" ] }, { "id": "task1163-94ad7315d12c4c07a8c815328f693edc", "input": "We interrogate the model using a Latin Hypercube sensitivity analysis to identify which mechanisms are critical to the observed infection of host cells and the release of measured virus particles.", "output": [ "method" ] }, { "id": "task1163-ac964d3c75294c39847bda9719ee810c", "input": "with a 50 % inhibition concentration of 3.85 mg/mL.", "output": [ "finding" ] }, { "id": "task1163-e1007e41fe984482b9c83e7ea4d5971a", "input": "evaluating the cellular immune response following infection has been hampered by the lack of a number of species-specific immunological reagents.", "output": [ "background" ] }, { "id": "task1163-259faefe833748efaf5d61cd458ed853", "input": "Many viruses cause disease within an infected host after spread from an initial portal of entry to secondary sites of replication.", "output": [ "background" ] }, { "id": "task1163-f82fb1ffaa4a431188ed57e38ae56ad7", "input": "severe acute respiratory syndrome coronavirus ( SARS-CoV ) and transmissible gastroenteritis virus ( TGEV ) in virus-infected and ectopically expressed cells.", "output": [ "purpose" ] }, { "id": "task1163-4c57b3953bd64ce4860d457245ec8d3d", "input": "observed unexpected O-glycosylation modifications on the receptor binding domain ( RBD ) of spike protein subunit S1.", "output": [ "finding" ] }, { "id": "task1163-3c17a3b133044c8c9bc297c878798629", "input": "By contrast , chemokines such as IP-10 or IL-8 are strongly upregulated.", "output": [ "background" ] }, { "id": "task1163-0a6205a3e0844057bd55bd6c1d93a85e", "input": "suggesting that larger and more numerous DMVs do not 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communicative behaviors ( message expression and reception ) in SNSs affected the communicators ' intentions to engage in MERS-preventive behaviors.", "output": [ "purpose" ] }, { "id": "task1163-6b9dbb54226c4f3890d84f7ae0d64a5d", "input": "while mitochondria were now found to be closely connected with antiviral immunity.", "output": [ "finding" ] }, { "id": "task1163-fbd4de9153e84425b86537aef79d776c", "input": "and its humoral , and cellular immune responses were evaluated in mice.", "output": [ "purpose" ] }, { "id": "task1163-c667122e83f34a959bc117f538cd0e09", "input": "the site of a 2014 EBOV outbreak.", "output": [ "background" ] }, { "id": "task1163-f644aea11bce4a7fb1062b231115aa53", "input": "This study evaluated impact of implementing a previously derived and validated bacteremia prediction rule.", "output": [ "purpose" ] }, { "id": "task1163-0dd59d3ccd3b40de86c6ea8e2de1b6bd", "input": "as well as some of the resources developed for the CC.", "output": [ "purpose" ] }, { "id": "task1163-db24a5611c0f42fd971d139154eeb2f8", "input": "Background : Middle East respiratory syndrome coronavirus ( MERS-CoV ) caused multiple outbreaks.", "output": [ "background" ] }, { "id": "task1163-81fb2fb1cb1444909cab02a7fb097bc5", "input": "urinary tract , and malarial complications.", "output": [ "finding" ] }, { "id": "task1163-4ada5cb18a6744b29c1aab9b094c1bc6", "input": "The present review will be focused on recent structural and protein-protein interaction information involving two viroporins found in enveloped viruses that target the respiratory tract ; ( i ) the envelope protein in coronaviruses and ( ii ) the small hydrophobic protein in paramyxoviruses.", "output": [ "purpose" ] }, { "id": "task1163-f483aabb0b0c4adcab0c7ac9f3fd1064", "input": "Objectives : This work presents a new approach to selecting proper health-based thresholds for a heat warning system which are different from thresholds of heat-health relationship.", "output": [ "purpose" ] }, { "id": "task1163-759884635230481eb3924edd21c380ab", "input": "This chapter focuses on specific cell populations and markers involved in cell division and regeneration.", "output": [ "purpose" ] }, { "id": "task1163-a1ccf192f13545ffac77fcd7951414ff", "input": "Mechanical interlocking induces considerable stability enhancement.", "output": [ "finding" ] }, { "id": "task1163-f41dcff389e94725b5f33658b56852d8", "input": "and established a virus probe library.", "output": [ "method" ] }, { "id": "task1163-eae95be2553d41789e38502d6945dc76", "input": "Design : Systematic rapid review and meta-analysis.", "output": [ "method" ] }, { "id": "task1163-92ea61806d21422ba135be540db8fc25", "input": "including a pregnant patient who died.", "output": [ "method" ] }, { "id": "task1163-1dcd11fe18d6499b94452aa802b59fa8", "input": "and Chlamydophila pneumoniae , and 13 respiratory viruses.", "output": [ "method" ] }, { "id": "task1163-35bd3f4bb2d44f14b29cc926a4e125c8", "input": "Methods : Bacteriophage FX174 was 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scientific communities working on Microfluidics , Biosensors and Lab-on-Chip.", "output": [ "background" ] }, { "id": "task1163-e8ebc8ed651e4895a9a5c5ea82956bb5", "input": "Notably , a number of autoantibody responses have been reported in children with KD.", "output": [ "background" ] }, { "id": "task1163-96a098bc78ba45f8a3f144e291849648", "input": "All rights reserved.", "output": [ "finding" ] }, { "id": "task1163-d9a0c924d0ed4d6c9ba692fb84e23ba7", "input": "In this study , we have examined the role of F protein cleavage site sequence in NDV virulence using reverse genetics technology.", "output": [ "purpose" ] }, { "id": "task1163-2873f68dde26437f9fe609b77706e914", "input": "SHAPU patients were at highest risk of harboring anelloviruses in their eyes.", "output": [ "finding" ] }, { "id": "task1163-4fa50f6c907d42e89e768ee48b2acdd5", "input": "The present study was designed to investigate the antiviral activity of pentoxifylline against JEV in vitro and in vivo.", "output": [ "purpose" ] }, { "id": "task1163-a65fe1cb759d4bd5bdeb8f093aa918a9", "input": "we designed and synthesized one-carbon homologated 6 0 - fluorinated-aristeromycin analogues.", "output": [ "method" ] }, { "id": "task1163-1547f7f277e844248e411c6dbd45efcb", "input": "ESI/MS , and computational calculations.", "output": [ "background" ] }, { "id": "task1163-05e95285d4924974b3c4e7258a1a3c19", "input": "In addition , C58 was used for interspecies hybridisation of murine T cell lines.", "output": [ "method" ] }, { "id": "task1163-cc1b1a3de46e4c70b28ab8404acb62c2", "input": "In contrast , SARS-CoV and TGEV EGFP-nsp15s distributed smoothly in the whole cell and did not form speckles.", "output": [ "finding" ] }, { "id": "task1163-ca34776df74640788bf1797adc3fad77", "input": "Individually housed calves were systematically assigned at birth to 1 of 2 feeding programs : free-access feeding ( ad libitum ) of acidified milk replacer ( ACD , n = 249 ) or traditional restricted feeding ( 3 L fed twice daily ) of milk replacer ( RES , n = 249 ).", "output": [ "method" ] }, { "id": "task1163-64678546735349099e702c5d9cceb24f", "input": "They were tested for the presence of coronavirus by consensus reverse transcription-PCR assay.", "output": [ "method" ] }, { "id": "task1163-ccbbfb26f4e44b6792b088369820bd6d", "input": "We have analysed the role of the milk protein a-casein by inactivating the corresponding gene in mice.", "output": [ "method" ] }, { "id": "task1163-1acae6068de54b6a847c25dc59dd523f", "input": "In yeast , these complexes function in a number of processes including endoplasmic reticulum-to-Golgi transport ( TRAPP I ) and an ill-defined step at the trans Golgi ( TRAPP II ).", "output": [ "background" ] }, { "id": "task1163-e3f4643fd85a4da185bafd3441c02058", "input": "Blue diamonds : male ; red squares : female ; green triangles : total population.", "output": [ "finding" ] }, { "id": "task1163-ff3674bf6e5448218043eecd93931e9d", "input": "Moreover , heparin was shown to bind to ephrin-B3 and to restrain infection of permissive cells in vitro.", "output": [ "finding" ] }, { "id": "task1163-f02e466202b5436c99fdd580370dd0eb", "input": "The clinical utility of Orthoquin PDI of oral biofilms is an area of active investigation and there is clear potential for wider range of clinical applications.", "output": [ "background" ] }, { "id": "task1163-81e854826ad443789edbf17fe70098d6", "input": "We report recent extensions to this approach.", "output": [ "purpose" ] }, { "id": "task1163-c2f6d782fcfd4d5da81d5679e4ee37d4", "input": "Bovine colostral Igs provide the newborn calf with passive immune protection against microbial infections until the calf 's own immune system matures.", "output": [ "background" ] }, { "id": "task1163-5228f3cafadf4ca7b112224355d8d489", "input": "14 and 36 for hemagglutination inhibition ( HAI ) testing.", "output": [ "method" ] }, { "id": "task1163-144e9100578d4df88eebc5cecff89b14", "input": "Nasal lavage fluids and turbinate epithelial cells were collected prospectively from 111 CRS patients and 50 controls.", "output": [ "method" ] }, { "id": "task1163-fe41f03a694a45c4bc6c3bd0a80f35ff", "input": "We also discuss the strengths and limitations of various assay platforms and describe a staged strategy for viral diagnostics.", "output": [ "purpose" ] }, { "id": "task1163-ce30e0e417044fa7a97745cf1707a6bb", "input": "were immediately performed and were continued for 1 h , without success.", "output": [ "finding" ] }, { "id": "task1163-0f94a5a13c8d413db82a67742f256847", "input": "EV-D68 was identified in 153/907 ( 16.8 % ) of patients tested.", "output": [ "finding" ] }, { "id": "task1163-313726a1da40481a9d34da98dac316af", "input": "The combination of microarray technology and sensitive isothermal nucleic acid amplification at 38 °C allows for a multiparameter analysis on a rather small area.", "output": [ "method" ] }, { "id": "task1163-49a12ad5d5274363b1da2f9a8459bbae", "input": "Expression of a small ( 35aa ) sequence in Domain III alone was sufficient to form speckles for all 3 viral nsp15s.", "output": [ "finding" ] }, { "id": "task1163-eaf86f7337764e788f7dd915802a8206", "input": "Coronaviridae is classified under the Nidovirale order ( 20 ).", "output": [ "background" ] }, { "id": "task1163-d107f215dbeb4df299b924045db472bc", "input": "quantifying the interplay between the HCoV-host interactome and drug targets in the human protein-protein interaction network.", "output": [ "purpose" ] }, { "id": "task1163-8f260c64e17149618535206efd3e423e", "input": "We found that mice shed viruses distinct from input viruses because they formed extremely large plaques in cell culture.", "output": [ "finding" ] }, { "id": "task1163-3b561d83a5864bfaaeedd7c243760ea4", "input": "acceptability , flexibility , stability and utility.", "output": [ "method" ] }, { "id": "task1163-0b4c2da6fd8f43919eea38677321c90c", "input": "A variant was previously identified and showed a distinct S1 gene homology with other local strains.", "output": [ "background" ] }, { "id": "task1163-3fc0c53cbbfe42a3a7165d2fd4c5d71c", "input": "Abreva is incorporated into the cellular plasma membrane and prevents fusion steps essential for HSV-1 entry into epithelial cells ( 8 ).", "output": [ "background" ] }, { "id": "task1163-ce1437965baf47318dc17973a55a0d98", "input": "the most efficacious 1,7-DAAC-based antimalarials employ a mechanism of action analogous to that of 4,7-ACQ-based antimalarials and are well tolerated by normal cells.", "output": [ "finding" ] }, { "id": "task1163-f12ca8d615ec4470b19764c845e4a259", "input": "By studying phylogenetic trees , scientists gain a better understanding of how species have evolved while explaining the similarities and differences among species.", "output": [ "background" ] }, { "id": "task1163-3ceee9e5c4ac431ebe21e9a6b4ec8485", "input": "In Section 3 , preliminary mathematical analysis of the proposed model is carried out.", "output": [ "method" ] }, { "id": "task1163-f6924dc502ff4a2e849ce8ea780cb307", "input": "We hypothesized that EMR-based surveillance systems that incorporate seasonality and other long-term trends would discover outbreaks of acute respiratory infections ( ARI ) sooner than systems that only consider the recent past.", "output": [ "method" ] }, { "id": "task1163-8a10c40fcf134084b0c5bb1d0bef89d0", "input": "cDNA was synthesized by using the Improm-II Reverse Transcription System and random primer ( Promega , Madison , WI , USA ).", "output": [ "method" ] }, { "id": "task1163-17409304b6484ef2b4956134d6a4cc2e", "input": "We found that PI3K-Akt-mTOR signaling is essential in sustaining rotavirus infection.", "output": [ "finding" ] }, { "id": "task1163-1d957d37495f4890877a7fb61fc80b3c", "input": "The phylogenetic analyses based on avian and mammalian coronaviruses showed the analysed IBV as closely related to turkey coronaviruses and distantly related to thrush and munia coronaviruses.", "output": [ "finding" ] }, { "id": "task1163-3aafa9c0a0e9418e94021dac711b5c46", "input": "and brain sections stained for pathological markers or analyzed for proinflammatory marker expression.", "output": [ "method" ] }, { "id": "task1163-a77f67aee5b043409fc5bd44b4ad2751", "input": "The median incubation period was 3.0 days and from illness onset to hospital admission was 2 days.", "output": [ "finding" ] }, { "id": "task1163-150e5d4289b44d08953a006e4384b42e", "input": "Furthermore , the oxygenation index in the survival group was significantly higher when compared with that in the fatality group.", "output": [ "finding" ] }, { "id": "task1163-076ee441f31f4f2f8d82489c5d85f683", "input": "Further , our results indicate that age factors should be considered when investigating the vaccination and therapeutic strategies for severe IAV infection.", "output": [ "finding" ] }, { "id": "task1163-3e5bbd78a31242e3baa445bbe06ae2b2", "input": "Double-stranded RNA-dependent protein kinase ( PKR ) is regulated by reovirus structural proteins.", "output": [ "finding" ] }, { "id": "task1163-deb8a53e5a5245459eb8b535a029fa6d", "input": "The APMVs produced mild or inapparent clinical signs in hamsters except for APMV-9 , which produced moderate disease.", "output": [ "finding" ] }, { "id": "task1163-48fb0c3de5824bce89613095be3abcd5", "input": "and a less viscous gel diluent was compared.", "output": [ "method" ] }, { "id": "task1163-1fbfec5ee97d454fab640aaf8a8f3689", "input": "Here , we report our findings of a head-to-head comparison of two viral vectors modified vaccinia Ankara ( MVA ) and a novel replication-competent modified vaccinia Tian Tan ( MVTT ) for inducing neutralizing antibodies ( Nabs ) via intramuscular and mucosal vaccinations in mice.", "output": [ "purpose" ] }, { "id": "task1163-2367268a6a7d447e813e0a908fcc5f5f", "input": "which could be attributed to that fact that several essential immediate early viral proteins for virus replication were impacted by resveratrol.", "output": [ "finding" ] }, { "id": "task1163-f34d850ef1a24168afec2c11bee0d9cd", "input": "Applicable models to improve adaptation in individuals include Folkman and Greer 's framework for stress appraisal and coping along with psychological first aid.", "output": [ "background" ] }, { "id": "task1163-42e4c28e1a5740cc80fda1b5583ce7a6", "input": "Material and methods : This diagnostic study was conducted from January 2014 until June 2015 in three major educational medical centers , Tehran , Iran.", "output": [ "method" ] }, { "id": "task1163-7645c9afa11f40b2bf321debd3665341", "input": "This review aims to provide an updated close-up of the literature on G4s in viruses.", "output": [ "purpose" ] }, { "id": "task1163-ca38d14b8bf0494c9f73fa105b049d16", "input": "fecal samples ( n = 59 ) were collected from dogs with or without diarrhea ( n = 21 and 38 , respectively ) in the Republic of Korea ( ROK ) in 2012.", "output": [ "method" ] }, { "id": "task1163-c1a974fbd06f46bc858da2587d6a20cf", "input": "In this review , we will discuss the relationship between viruses and autophagy and summarize the current knowledge on the functions of viral proteins contributing to affect autophagy process.", "output": [ "purpose" ] }, { "id": "task1163-450072dedee6470389bc0f4ca6507c7a", "input": "and parvovirus B19 in patients with HIV disease.", "output": [ "purpose" ] }, { "id": "task1163-13c36a605960430a9cda3706f45945a9", "input": "We assumed that all of the individuals in a population group have the same location visiting schedule on weekdays.", "output": [ "method" ] }, { "id": "task1163-49f6e2ad871a4c0ba871cc5fdcea6a0f", "input": "and self-efficacy related to SARS and eight other diseases.", "output": [ "method" ] }, { "id": "task1163-d94600d9873a422780736fee28355214", "input": "Irrespective of previous diagnosis , nasopharyngeal or nasal swab specimens were randomly selected and tested using real-time PCR from three sites during 2007 from patients younger than 6 years old.", "output": [ "method" ] }, { "id": "task1163-5050eaab6921427aa2e22996d1c303ac", "input": "before the ophthalmological check , it is mandatory to know if the patient has COVID-19 symptoms and if the patient has recently been in contact with a confirmed COVID-19 case.", "output": [ "background" ] }, { "id": "task1163-0c284175beee41d3a36905f5c20d5c80", "input": "is involved in targeting of stable RNA for degradation.", "output": [ "finding" ] }, { "id": "task1163-aa344bcb68774712862c105756b57601", "input": "in the month of the epidemic growth.", "output": [ "method" ] }, { "id": "task1163-9cf3346b4f534669bd13261a538445f3", "input": "and incubated with 5 µg/ml of FY1 or MEDI8852 on ice for 1 hour.", "output": [ "method" ] }, { "id": "task1163-d0d9009a52f0433f98255fb2331cc089", "input": "In this study , we explored the potential of the plant-derived photosensitizing agent Orthoquin TM to mediate photodynamic inactivation ( PDI ) ( 10 ) of virions.", "output": [ "purpose" ] }, { "id": "task1163-fe82ba4cf385420286d378fcb8613a38", "input": "and at identifying a possible correlation between viral loads and disease severities.", "output": [ "purpose" ] }, { "id": "task1163-8aa892bfdbf940d5985a04ac9cb7db91", "input": "In this chapter , we describe several databases ( such as GENEDB , BRENDA , KEGG , METACYC , the THEM-PEUTIC TARGET DATABASE , and CHEMBaNK ) and algorithms ( including PATHOLOGIC , PATHWAY HUNTER TOOL , AND AUTODOCI0 which have been developed to facilitate the bioinformatic analyses underlying these approaches.", "output": [ "purpose" ] }, { "id": "task1163-f30a51f9716b4f9bb125cb69ab984ea7", "input": "Results.", "output": [ "finding" ] }, { "id": "task1163-a5d3a2249f1a4251bdf880d49f84f2cd", "input": "This review highlights the key role that autophagy plays in the innate immune system and the acquired immune system.", "output": [ "purpose" ] }, { "id": "task1163-c36d1b08ae5a4ea09c2f296cac834f20", "input": "and the energy parameters of HotKnots V2 .0.", "output": [ "method" ] }, { "id": "task1163-47258a3c7c7f46c8bbfe1b7fa573ea12", "input": "the ability to cause systemic infection was the strongest predictor of severe disease.", "output": [ "finding" ] }, { "id": "task1163-6f1976e8d85a4f80999397519d7c2541", "input": "the use of personal protective equipment during MERS-CoV compared with the period before MERS-CoV increased dramatically from 2,947.4 to 10,283.9 per 1,000 patient-days ( P < .0000001 ) for surgical masks and from 22 to 232 per 1,000 patient-days ( P < .0000001 ) for N95 masks.", "output": [ "finding" ] }, { "id": "task1163-ddb97d6f22fe419eac8ba99f0018577e", "input": "Induced sputum and serum were collected.", "output": [ "method" ] }, { "id": "task1163-191a2ea4911c49b095cdfb1a9f4f2967", "input": "Objectives : To evaluate registered nurse compliance with standard precautions and to analyze the factors that affect compliance.", "output": [ "purpose" ] }, { "id": "task1163-b734cc9179e04f3cbf99b6d46b422721", "input": "it is difficult to synthesize stable prodrugs of this compound.", "output": [ "background" ] }, { "id": "task1163-0171132701b84326a2ff9d37fc169a74", "input": "in-depth interviews , and direct field observation.", "output": [ "method" ] }, { "id": "task1163-a35e5fc48e614eb998b17278bbc13a00", "input": "Atmospheric aerosol particles are presumably one of the media.", "output": [ "background" ] }, { "id": "task1163-96823108c6b54ee8bab0cdd934fc6e92", "input": "In total , 485 calves ( ≤ 21 d of age ) were enrolled at first diarrhea diagnosis ( fecal score ≥ 2 defined as loose to watery ) and randomly assigned to receive an oral dose of lactoferrin ( 3 g of lactoferrin powder dissolved in 30 mL of water ) or 30 mL of water ( control ) once daily for 3 consecutive days.", "output": [ "method" ] }, { "id": "task1163-d7864cc2ed9c48328500edd13b138506", "input": "some underlying design principles and the prospects for future developments.", "output": [ "purpose" ] }, { "id": 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"method" ] }, { "id": "task1163-34345f6a30a94a9aa835617a175b4b30", "input": "A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported.", "output": [ "purpose" ] }, { "id": "task1163-2d2ea0ba20d94f2ca54480c7facf32db", "input": "Paromomycin ( 100 mg/kg ) was used as a positive control.", "output": [ "method" ] }, { "id": "task1163-4f0b10c715d343d5aa10a0069dc148d3", "input": "Virulent BCV was actively introduced in one of the groups by means of a transmitter calf.", "output": [ "method" ] }, { "id": "task1163-52d24305f5324ee8ab1ae6d7d6828a99", "input": "and 72 C for 15 min.", "output": [ "method" ] }, { "id": "task1163-ea5a017465bc41a38b73632bd164826d", "input": "1.8 mM dNTPs and at an incubation temperature of 67.1 °C.", "output": [ "background" ] }, { "id": "task1163-7da99e93b20c45beabc239f1bfed7bc4", "input": "tethering is critical to ensuring that specificity is achieved.", "output": [ "background" ] }, { "id": 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"task1163-68142f7cbc5940d6841e31181931ebab", "input": "Experiments to study the mechanism of antiviral action of pentoxifylline using in vitro translation of viral mRNA suggested that the drug did not interfere either with early or late protein synthesis but most likely exerted its action on virus assembly and/or release.", "output": [ "finding" ] }, { "id": "task1163-72591068eac048db92e71b11d6ec9731", "input": "and to compare anaesthetic regimen and clinical outcomes in parturients with or without COVID-19 undergoing cesarean delivery.", "output": [ "purpose" ] }, { "id": "task1163-4dd546b8c5d24806b02d905e18dae39c", "input": "Third , rotavirus may sequester NF-κB in viroplasms.", "output": [ "background" ] }, { "id": "task1163-ac0d8d82728f4d4a8ddc3b6c7dcd2466", "input": "resulting in a detection limit of 5 ng/mL ( or 1 ng in terms of amount ) and enhanced compatibility with practical applications such as clinical biopsy.", "output": [ "finding" ] }, { "id": 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based on synthetic biology principles to detect a specific viral function rather than a particular viral protein.", "output": [ "purpose" ] }, { "id": "task1163-3f74a17bd5b34361b8dddcb4ccd0ce76", "input": "We postulated that a quantitative analysis of beat pattern would improve PCD diagnosis.", "output": [ "purpose" ] }, { "id": "task1163-b400b035919645099417e510361e254f", "input": "These interactions can also indirectly affect the host response to viral infection.", "output": [ "background" ] }, { "id": "task1163-f484e22decb2407db42593b62d2ea249", "input": "The botanical plant extract Orthoquin TM is a powerful photosensitizer with antimicrobial properties.", "output": [ "background" ] }, { "id": "task1163-c0b82e4e9d6f4c04ac810cd29299514b", "input": "which was historically used as a smallpox vaccine for millions of Chinese people.", "output": [ "background" ] }, { "id": "task1163-002e791f1e1c4788ad4a542d25b55ad8", "input": "Fortunately , the biomedical community has been able to 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"output": [ "purpose" ] }, { "id": "task1163-0977c7e0ecc941f1b3512fb24c5da304", "input": "GLTSCR2 should be seriously considered as a therapeutic target for developing broad spectrum antiviral agents to effectively control viral infection.", "output": [ "finding" ] }, { "id": "task1163-ce43bdb3939d4d5db86337854dc6b725", "input": "Autophagy was also reported to suppress the magnitude of host innate antiviral immunity in certain cases.", "output": [ "background" ] }, { "id": "task1163-8ace9b18c45b4be280971841a427fd3f", "input": "purification , and characterization of vaccine protective antigens in veterinary vaccines was also identified as a priority.", "output": [ "finding" ] }, { "id": "task1163-9780da34cf3e4169b6453a0c832140b8", "input": "a cell culture system used for manufacturing of MVA vaccines.", "output": [ "method" ] }, { "id": "task1163-9e852cf463884da8954666b16aa2914e", "input": "and it does not require a multiple sequence alignment.", "output": [ "background" ] }, { "id": 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electrophoresis ( CE ) technique was developed.", "output": [ "purpose" ] }, { "id": "task1163-65763b7ededd4d66bb6c28448764c039", "input": "and any changes to the antibiotics regimen as results of the blood cultures.", "output": [ "method" ] }, { "id": "task1163-b1908f128bb442d18955103296de2660", "input": "We hypothesize that M. haemolytica colonization of cattle during its commensal state may include biofilm formation.", "output": [ "purpose" ] }, { "id": "task1163-f42ec39e57c64c759094b6cd174e4abb", "input": "vaccine-induced immunity and self-reported symptoms.", "output": [ "purpose" ] }, { "id": "task1163-1cc3fcce7000446d9d7d21f2f44c43e5", "input": "which consisted of 145 serum specimens from patients confirmed by RT-PCR to be positive for human respiratory infections.", "output": [ "method" ] }, { "id": "task1163-eeda8bacd34c4875a7ce1e4f2342c087", "input": "We collected serum samples from 50 healthy blood donors ( Cohort A ) as negative controls Sanquin Blood Bank ( Rotterdam , the Netherlands ) obtained written informed consent for research use.", "output": [ "method" ] }, { "id": "task1163-36a0a2bb6e714f4e89a4509e9b6eb0e7", "input": "designated BALB/cV , exhibits an intermediate mammary tumor incidence ( 47 % ) and harbors a distinct milk-transmitted mouse mammary tumor virus ( MMTV ).", "output": [ "background" ] }, { "id": "task1163-3474289ef08749108849a25bd15fc784", "input": "Our data have implications for people who maintain low levels of anti-VTT Nabs after historical smallpox vaccination.", "output": [ "finding" ] }, { "id": "task1163-7785efe2fb664084b5ac11211db227aa", "input": "but highly infectious organisms is important as well.", "output": [ "background" ] }, { "id": "task1163-1ea716cbdd8a4326b65ceae90cd0e724", "input": "Chronic obstructive pulmonary disease ( COPD ) is a disease with high prevalence and substantial associated economical burden.", "output": [ "background" ] }, { "id": "task1163-269d2a149bf948ff930bd58e6556ac69", "input": "Here , we dissect the contributions of the individual complement activation pathways to the protection from WNV disease.", "output": [ "purpose" ] }, { "id": "task1163-dd2d5a79f46f40249dd6a3433bbac56e", "input": "The highest mean titre obtained by ELISA was approximately 1.5-3.5 times greater than those obtained by the other techniques whilst CFT gave the lowest values.", "output": [ "finding" ] }, { "id": "task1163-ac18afd1bfa24a98820c0a973d016a5d", "input": "Introduction : This study compares the detection of 14 common respiratory viruses by two different real-time reverse transcription polymerase chain reaction ( rRT-PCR ) methods : in house singleplex tests developed by the Centers for Disease Control and Prevention and the commercially available Fast Track Diagnostic ( FTD ® ) Respiratory Pathogens 33 multiplex test.", "output": [ "purpose" ] }, { "id": "task1163-b238f11cd96e48f39cf0126b7b388674", "input": "In this study , we propose a more flexible geometric structure to be used as a spatial or spatio-temporal scanning window.", "output": [ "purpose" ] }, { "id": "task1163-1b2a7b0f52bb409cb2f61f1cdb89e611", "input": "Methodology/Principal Findings : We report results of virological analyses performed in the Public Hospitals of Marseille during the first months of the outbreak.", "output": [ "method" ] }, { "id": "task1163-161938b6c33f4080b280e823c2f2ff9b", "input": "is essential to the virus life cycle.", "output": [ "background" ] }, { "id": "task1163-3467fcdc56ae418dbd64fe39326a9676", "input": "and their relationships in this treatise based on a multi-subnet composited complex network model ( MCCN ).", "output": [ "purpose" ] }, { "id": "task1163-47b2b2d0c1eb438888d1affc40a7c77d", "input": "In the present study , we characterized the previously unidentified CPV-2c variant and investigated the distribution of CPV-2 variants in Taiwan.", "output": [ "purpose" ] }, { "id": "task1163-f8d9359dcd394e0cb3ca430a781483e2", "input": "while means and standard deviations were calculated for continuous variables.", "output": [ "method" ] }, { "id": "task1163-b08a98a3d17c4311870f0a010608e589", "input": "it outlines the key pillars of the emerging global energy order.", "output": [ "purpose" ] }, { "id": "task1163-7d6d793daafd4a1a8b962a78d7b92fb9", "input": "We reviewed the data and metadata availability and quality of these studies.", "output": [ "finding" ] }, { "id": "task1163-ab9c4d2b915a4a28aa93c0a1ab748a92", "input": "as these are most interesting from an immunological point of view.", "output": [ "purpose" ] }, { "id": "task1163-b0e0951f6d6d4915bd5286eefb1df12e", "input": "Seven days after treatment , many immature Schwann cells but no oligodendrocytes were found between the denuded axons.", "output": [ "finding" ] }, { "id": "task1163-948ef7dd5cda452fb9014d7c697c16dc", "input": "suggesting that PAP observed in this family could be inherited as an autosomal-dominant trait from the mother.", "output": [ "finding" ] }, { "id": "task1163-0886fedbc8a0479483b6f0b8039a347d", "input": "and ultrastructural analysis was performed using electron microscopy.", "output": [ "method" ] }, { "id": "task1163-a7b1ffee5ccc4874af5eb3ea8ce8ba25", "input": "Evidence supports the goal of developing and maintaining an organizational culture of resilience in order to reduce the expected stress of an influenza pandemic on healthcare workers.", "output": [ "finding" ] }, { "id": "task1163-1eba619d187440ba972cb1cd544c27c4", "input": "and efficiencies of 53 % to 79 % for surface samples in localized systems.", "output": [ "method" ] }, { "id": "task1163-c5646d9b3dbf4dddb9af6299e0c0f9a7", "input": "as well as cell viability.", "output": [ "method" ] }, { "id": "task1163-7f8656f10b994179b234c725726084d3", "input": "Seventy-one patients completed the 15-year follow-up.", "output": [ "method" ] }, { "id": "task1163-b095cbfd46f44011811cc1f162827641", "input": "Students completed weekly electronic surveys and submitted self-collected 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the views of individuals on the nature and limits of this duty.", "output": [ "purpose" ] }, { "id": "task1163-b4a97f0407a64d7caad94234848265f2", "input": "This article reviews the recent progress for immune biology of Vγ2 Vδ2 T cells in infections.", "output": [ "purpose" ] }, { "id": "task1163-ad5fce92e97144e0b82ea50c2c22808a", "input": "In this review , the characteristics of the feline APR are described.", "output": [ "purpose" ] }, { "id": "task1163-0d08a9ffa9db44f386be979d17e7ddfd", "input": "oropharyngeal mucosal sites , and lymph nodes draining the pharynx.", "output": [ "finding" ] }, { "id": "task1163-5d8f41a9fdaa4377825f472e1e6fb319", "input": "and was propagated 8 times in HRT-18 cells.", "output": [ "purpose" ] }, { "id": "task1163-7891a68603a541e58b019b71a18fd736", "input": "This makes amyloid fibrils a challenging focus for inhibition studies because the peptides and proteins that form amyloid fibrils can not be targeted based on a sequence motif.", "output": [ "background" ] }, { "id": "task1163-7255bcdc51ae41118d3b241e8cfc27b9", "input": "Immune responses are a double-edged sword.", "output": [ "background" ] }, { "id": "task1163-594c36c0afaf418aaa12bdfff55f1cd5", "input": "but also their common orientation on one side of the peptide that is engendered by the WX 2 WX 2 W motif.", "output": [ "finding" ] }, { "id": "task1163-7161eef4381648f7b1f97b68dedd3a09", "input": "and the β3-β4 turn failed to contact pAPN.", "output": [ "finding" ] }, { "id": "task1163-456b081cf7274c78bf446e2f573cb63c", "input": "international health agencies have set the goal of eliminating HBV infection by 2030.", "output": [ "background" ] }, { "id": "task1163-52da1f0078254d90a7de98c73a00b3d1", "input": "The findings provide a scientific basis for the use of K-601 as anti-inflammatory and antipyretic agent in traditional Chinese medicinal practice.", "output": [ "finding" ] }, { "id": "task1163-8a6f89494175437589fb35c8935672c0", "input": "Broncho-alveolar lavage ( 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blood mononuclear cell ( PBMC ) samples were obtained from a single healthy donor after vaccination following written consent.", "output": [ "method" ] }, { "id": "task1163-77168c2ab12f47bfb4c7b8a224795c78", "input": "We also propose and illustrate methods for aggregating specific `` bug-drug '' data.", "output": [ "method" ] }, { "id": "task1163-feb33336c11f4ca4a3c1c576b8bbf39f", "input": "DMVs is why they exist in the first place.", "output": [ "finding" ] }, { "id": "task1163-740a3313901542dfa240d4b2f8f19627", "input": "and discuss the past and future drivers in view of future challenges in an evolving scenario.", "output": [ "purpose" ] }, { "id": "task1163-fb682e70cf11438abcfea9f4c76be707", "input": "Coronavirus envelope ( E ) protein is a small integral membrane protein with multi-functions in virion assembly , morphogenesis and virus-host interaction.", "output": [ "background" ] }, { "id": "task1163-840b3efc7f6c46b0b4a54a07d2d31ccf", "input": "Section 4 is devoted to the global stability of the endemic equilibrium using geometric approach while 52 in Section 5 backward bifurcation and forward bifurcation with hysteresis effect is presented.", "output": [ "method" ] }, { "id": "task1163-6388d8c80bc84d049ecb0482558e91e4", "input": "The PFGE banding patterns were compared visually.", "output": [ "finding" ] }, { "id": "task1163-c1b61429b8974016a6fa16f0b3a2ec32", "input": "their epidemiology , pathogenesis , clinical features , and management and control.", "output": [ "purpose" ] }, { "id": "task1163-a922cccd06e444cab01f7c531443dc90", "input": "In this review , we discuss some of the recent findings of host cell factors that might be exploited by HCoVs to facilitate their own replication cycle.", "output": [ "purpose" ] }, { "id": "task1163-1f8c991f9f664bf49bda93ae9a4fe9bf", "input": "Thailand , were used for model construction and validation.", "output": [ "method" ] }, { "id": "task1163-8ca2de1bdc9e4696a12a1abeffec2994", "input": "Several proteins known to be 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oligosaccharide structures facilitate these functions during viral pathogenesis.", "output": [ "purpose" ] }, { "id": "task1163-e0e31867a047438894bb04ac3b6807f4", "input": "We will also discuss emerging applications and future directions of protein microarray technology in the global frontier.", "output": [ "purpose" ] }, { "id": "task1163-610b8bb8e4ab4725a417a89d0af906dd", "input": "It briefly reviews the history of chiropteran viruses and discusses their emergence in the context of geography , phylogeny , and ecology.", "output": [ "purpose" ] }, { "id": "task1163-290302898bef44e98d98963898b3c168", "input": "It also inhibited NF-jB activation and reduced the upregulation of proinflammatory cytokines induced by the infection.", "output": [ "finding" ] }, { "id": "task1163-366e852c201f4fe28c21679f1f91c099", "input": "Data were compared between survivors and non-survivors.", "output": [ "method" ] }, { "id": "task1163-d5fdf7ee92fa4810b4916302fc61d60b", "input": "Materials and Methods : This retrospective study enrolled all patients admitted to a 12-bed SARS intensive care unit ( ICU ) in a tertiary care medical center in Taipei between May 15 and July 17 , 2003.", "output": [ "method" ] }, { "id": "task1163-90cc3e96cae34ef1917ba36b71638786", "input": "whereas RIG-I and SG markers did not.", "output": [ "finding" ] }, { "id": "task1163-6d3dcc9a6b5d4f3c8471a324ba573b7f", "input": "Here , we discuss issues related to the establishment of this technology and areas that are highly promising for its application.", "output": [ "purpose" ] }, { "id": "task1163-9d36f68bd0d84d2d95100e2cbd6bc573", "input": "Today , it estimated that about one-third of the world population is infected with the TB bacillus.", "output": [ "background" ] }, { "id": "task1163-3c55f41432fa45f3a0479bde760c2109", "input": "untreated subjects , indicating that this antibody may be a suitable MERS-CoV treatment.", "output": [ "finding" ] }, { "id": "task1163-3f025185e2f04c7480b378cb9bdc2b2d", "input": "Gammaand Deltacoronaviruses based on sequence comparisons of entire viral genomes ( 21 , 22 ).", "output": [ "background" ] }, { "id": "task1163-0bb238931d72463590b7dc711dd972f9", "input": "As a consequence of infection there are alterations in the permeab ~ dity of the plasma membrane which may contribute to cellular damage.", "output": [ "background" ] }, { "id": "task1163-c21a8733a1a94f5cb7deaa9a4c1b8e82", "input": "Currently , it is unclear if flexibility in this region is an inherent property of prefusion RSV F or if it is related to inadequate stabilization of site Ø in the engineered variants.", "output": [ "background" ] }, { "id": "task1163-84cd5590ef4a41a9ae833ea50c0fc8ce", "input": "In this work we undertook a mutational analysis to attempt to identify specific amino acid sequences within the spike glycoprotein crucial for molecular mimicry of Fc ␥ RII.", "output": [ "purpose" ] }, { "id": "task1163-468e6cc27dec465c81bcfff69015b3f2", "input": "Purpose : COVID-19 ( coronavirus disease 2019 ) is a public health emergency of international concern.", "output": [ "background" ] }, { "id": "task1163-eee88f8bb07f4095835dc5091a7185ca", "input": "In this paper , we present an algorithmic solution to produce coding sequences that follow exactly a primary amino acid sequence and a desired GC-content.", "output": [ "purpose" ] }, { "id": "task1163-0bcb63afe6644e16adea670b3aa85460", "input": "translation , replication , and genomic stability.", "output": [ "background" ] }, { "id": "task1163-0bad70b0d5f0442598e51b61548be40e", "input": "The frequency of disease ( diarrhea , dehydration , depression , signs of respiratory disease ) through 35 d following diarrhea diagnosis was not significantly different for calves in the lactoferrin and control groups.", "output": [ "finding" ] }, { "id": "task1163-d3b917a40eb24748897baab79f3b0a27", "input": "Here we report a novel method for identification and typing of HEVs based on information derived from their whole genomes.", "output": [ "purpose" ] }, { "id": "task1163-412922eff984417c98f13c3db3e7023b", "input": "it should be noted that the analytical method can influence the composition of the library ( e.g. , trace of acid in liquid chromatography ( LC ) ).", "output": [ "background" ] }, { "id": "task1163-46281db6aac74f23b80b2e0fff6a3279", "input": "there remains a lack of available reagents for studying hamster immune responses.", "output": [ "background" ] }, { "id": "task1163-156e7584f39a45e3ba6068bc3f794613", "input": "Objectives : Severe influenza can lead to Intensive Care Unit ( ICU ) admission.", "output": [ "purpose" ] }, { "id": "task1163-39af4b60d6994e39a02463f000293bf4", "input": "we hope that this review helps in the understanding and eradication of the threatening disease.", "output": [ "purpose" ] }, { "id": "task1163-7d1221ab92ac4f78a31ca9132734e7df", "input": "We sampled residents using a cross-sectional intercept design during the WHO Phase 6.", "output": [ "method" ] }, { "id": "task1163-e2e0e3867db44c1099a9ed5af86140fb", "input": "These drugs interrupt HSV genome replication by different mechanisms of action.", "output": [ "background" ] }, { "id": "task1163-3b51f6dfc5be429781bbb320f8e49d50", "input": "either by direct infection or by deposition of immune complexes.", "output": [ "background" ] }, { "id": "task1163-bf1737f90af648bf82c6dd17844c52fa", "input": "Here we show that IFITM proteins restricted infection mediated by the entry glycoproteins ( GP 1,2 ) of Marburg and Ebola filoviruses ( MARV , EBOV ).", "output": [ "purpose" ] }, { "id": "task1163-75b15bc9a47643438e0efec2d93cfa73", "input": "followed by development with TMB solution ( KPL ).", "output": [ "method" ] }, { "id": "task1163-7827f48faef7402aae052c26410db697", "input": "In this observational study , we systematically applied currently approved diagnostic techniques in patients hospitalized for CAP in order to determine the proportion in which an etiological agent could be identified.", "output": [ "purpose" ] }, { "id": "task1163-ad7ee5bd9c294d53ae998bc1f81cd45b", "input": "cost , time , and pointof-care applications.", "output": [ "purpose" ] }, { "id": "task1163-bd6c717a6dbb42049c0e0fe47052bbb7", "input": "This work established a good foundation for further studies on the production of anti-TGEV vaccines.", "output": [ "finding" ] }, { "id": "task1163-d589b955de9b49ff8d66d51a0a555c61", "input": "It also was more sensitive at detecting the summer wave of the 2009 influenza pandemic.", "output": [ "finding" ] }, { "id": "task1163-afac4f0b904b4d3eb79776e84da38858", "input": "Here , we investigated the effects of CTSL on SIgA responses and invariant chain ( Ii ) degradations in the cocultured swine dendritic cells ( DCs ) and B cells system in vitro.", "output": [ "purpose" ] }, { "id": "task1163-3aee909a242749b4a3eb8319f0bf1695", "input": "the proportion of influenza-infected travellers who were febrile was low and ITIS were not much better than chance at identifying travellers likely to be influenza-infected.", "output": [ "finding" ] }, { "id": "task1163-0eb12132d2e34a06b4f59725af285bce", "input": "This research examines whether maternal optimism/pessimism is associated with unplanned Cesarean section deliveries in China.", "output": [ "purpose" ] }, { "id": "task1163-9da9ef850f614060b4a01babbbcbe892", "input": "These studies have significantly furthered our understanding of the principles that underlie structural organization in viruses.", "output": [ "background" ] }, { "id": "task1163-08fe028797b44f8fb0ac1f9f5aa7b69d", "input": "and the conversion of LC3-I ( cytosolic ) to LC3-II ( membrane-bound ) forms.", "output": [ "finding" ] }, { "id": "task1163-1755f7a0c58f46dfb5ac046949cfa4fb", "input": "Primary care doctors were randomized to mask wearing and non mask wearing clinical consultations in public primary care clinics in Hong Kong.", "output": [ "method" ] }, { "id": "task1163-f6430f8d5e584ef590e8d3785fd61ac3", "input": "and DEAE Toyopearl ( Tosoh Bioscience ).", "output": [ "method" ] }, { "id": "task1163-7579c09c293e4e029644114e62309382", "input": "A replicon-based DNA vaccine encoding VP2 gene of canine parvovirus ( CPV ) was developed by cloning CPV-VP2 gene into a replicon-based DNA vaccine vector ( pAlpha ).", "output": [ "method" ] }, { "id": "task1163-a2d2ecc1f5cc4c06a038b070f7323e2f", "input": "Objectives : To compare the efficacy and safety of inhaled IFN-b with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses.", "output": [ "purpose" ] }, { "id": "task1163-cf2c0feaaf1e45d284cdc4ebbfa422c4", "input": "Encephalomyocarditis virus , a programmed ؊ 1 ribosomal frameshift ( ؊ 1 PRF ) occurs at a conserved G _ GUU _ UUU sequence within the 2B-encoding region of the polyprotein open reading frame ( ORF ).", "output": [ "background" ] }, { "id": "task1163-a3ebba700df34e08a1c88df9cb953562", "input": "because of short half-life , drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients.", "output": [ "background" ] }, { "id": "task1163-5b1ebbbb6e8d40c496f4696356437354", "input": "SFTPC , ABCA3 , CSF2RA , CSF2RB , and GATA2.", "output": [ "method" ] }, { "id": "task1163-a5cd0de04b6340078d35a0630d760fa0", "input": "All travellers had been in contact with Case 1 while he was sick , with initially non-respiratory complaints.", "output": [ "finding" ] }, { "id": "task1163-672095d5bc874025813b3e7f20298bf2", "input": "63 male and 30 female.", "output": [ "method" ] }, { "id": "task1163-255f4cd5e911434a90e9c4f5051d76f6", "input": "Additional flights served new African air passenger markets and secondary airports in established markets.", "output": [ "background" ] }, { "id": "task1163-1aa044f575d34cf89abaabcddde01ff4", "input": "We sequenced SARS-CoV-2 from 340 individuals.", "output": [ "method" ] }, { "id": "task1163-033badbc091c43b7bd0f08c609274e8b", "input": "it is necessary to understand the transmission dynamics of RSV.", "output": [ "purpose" ] }, { "id": "task1163-2c603af5d4504aa7927f0a0a2d10b774", "input": "we sequenced the S gene of several nondemyelinating recombinant viruses.", "output": [ "method" ] }, { "id": "task1163-3dccc5310bf7425fb879a3024c88c48b", "input": "Vesicle-mediated transport is a process carried out by virtually every cell and is required for the proper targeting and secretion of proteins.", "output": [ "background" ] }, { "id": "task1163-f17cd58d172042648e8a63dd97c895c5", "input": "Purpose : The aim of the study was to identify characteristic clinical features and outcomes of critically ill patients with confirmed severe acute respiratory syndrome ( SARS ).", "output": [ "purpose" ] }, { "id": "task1163-194c4cd1d8994d318821d002dbc1770d", "input": "clinicians must be aware of drug toxicities and drug interactions.", "output": [ "background" ] }, { "id": "task1163-2bfc91dc0b1c4d2c9aed58b8974b979e", "input": "Recent studies have demonstrated that peptides derived from the two heptad repeat regions ( HR1 and HR2 ) of paramyxovirus fusion proteins could be used as inhibitors of virus fusion.", "output": [ "background" ] }, { "id": "task1163-df186937608a4103acf2c5d065e65157", "input": "These results show that the S cytoplasmic domain is palmitoylated and that palmitoylation of the membrane proximal cysteine clusters I and II may be important for S-mediated cell fusion.", "output": [ "finding" ] }, { "id": "task1163-ac1e7cfc42324b65a6b401fa54569aef", "input": "A positive correlation was observed between the blood lactic acid level and the APACHE II scores ( r = 0.656 , P < 0.05 ).", "output": [ "finding" ] }, { "id": "task1163-a0c5b45b6d124676a11dd27807707bc2", "input": "African strains of the virus were not re-sampled in Saudi Arabia despite sampling approximately 1 year after importation from Africa.", "output": [ "finding" ] }, { "id": "task1163-5056d6fd8be844afa0a1e5990bab0469", "input": "indicating that EV71 3AB is a nucleic acid chaperone protein.", "output": [ "purpose" ] }, { "id": "task1163-fb7eaae5835d4b93b4ac1a2a3768a4e7", "input": "homology modeling , and biochemical assays to search for novel GTase inhibitors.", "output": [ "method" ] }, { "id": "task1163-a7fc95b4f47d4d47908d684fd9bcd6fc", "input": "Potential adverse effects on human and animal health in the livestock sector must also be taken into account.", "output": [ "finding" ] }, { "id": "task1163-40f6ab05a4a4412289a45021d3d71656", "input": "Our research objective was to develop a robust and rapid multiplex TaqMan real-time PCR ( qPCR ) to detect C. michiganensis in general and C. michiganensis subsp. nebraskensis with enhanced reliability and accuracy by adding non-complementary AT sequences to the 5 ' end of the forward and reverse primers.", "output": [ "purpose" ] }, { "id": "task1163-590a338e80c443c1ac9c121f37f1e17f", "input": "For the affinity optimization , full-length IgG constructs containing the different variants created by CDR based parsimonious mutagenesis were expressed transiently in 293 T cells and supernatants were screened by ELISA to select clones that resulted in increased binding activity to H3 while maintaining or increasing the binding activity to H1 HA proteins.", "output": [ "method" ] }, { "id": "task1163-bbcadfa30ded4411b430e89832d825fa", "input": "This study therefore evaluated the operational efficiency of 21 AsiaePacific airports between 2002 and 2011.", "output": [ "purpose" ] }, { "id": "task1163-a078185b40c645558bec55c9bf17bdfc", "input": "Finally , challenges and issues facing the development of diagnostic and prognostic biochips are discussed in detail.", "output": [ "purpose" ] }, { "id": "task1163-b2a46f1e048e49e992bc8103da448df3", "input": "Ad12 induces neuro-ectodermal tumors in newborn hamsters ( Mesocricetus auratus ).", "output": [ "background" ] }, { "id": "task1163-5469ae74c4e84582b35487cd83a6523b", "input": "was performed on DNA fragments obtained by digestion with the restriction enzyme SmaI by use of a CHEF-MAPPER apparatus.", "output": [ "finding" ] }, { "id": "task1163-c1da2860be1c42be82212433f3422b7f", "input": "This paper presents the results of investigations whose aim was to describe the influence of the pressure difference level on the ability of contaminants migration between neighbouring rooms in dynamic conditions associated with door swing.", "output": [ "purpose" ] }, { "id": "task1163-4c3dc9e4570d4e29a5e8fc929efa2dcd", "input": "demonstrating its promising utility in monitoring and assessing the risk of potential laboratory contamination.", "output": [ "finding" ] }, { "id": "task1163-055cbefb98e04b29b9477f04b72f339c", "input": "We report a laboratory-confirmed case of severe acute respiratory syndrome ( SARS ) in a pregnant woman.", "output": [ "purpose" ] }, { "id": "task1163-ccbe72a1e8414f0ba03ebcfa53e0fbb5", "input": "Virus transmission is faecal-oral.", "output": [ "background" ] }, { "id": "task1163-186007558e9547dd9e953db5b6ad5fc4", "input": "starting at one side , and progressing to the other.", "output": [ "finding" ] }, { "id": "task1163-d7896a7394a2418ca6f8602057c36334", "input": "serology , urine antigen tests , and molecular detection.", "output": [ "method" ] }, { "id": "task1163-f103a6feac244d47ba6da07f26080234", "input": "Objectives : To assess the feasibility and patient acceptability of self-collected foam nasal swabs for detection of respiratory viruses in SOT recipients and to define the virologic and clinical course.", "output": [ "purpose" ] }, { "id": "task1163-bacac987a17b47148764777d77097585", "input": "Here we will discuss possible mechanisms for protein sorting in the context of cisternal maturation and propose that a common mechanism is sufficient to explain both transport of cargo and sorting of resident proteins.", "output": [ "purpose" ] }, { "id": "task1163-136c66ddf2bf48bb9f8f8d80614f22e9", "input": "We expressed human SCARB2 gene in NIH3T3 cells ( 3T3-SCARB2 ) to study the mechanisms of EV71 entry and infection.", "output": [ "method" ] }, { "id": "task1163-430dfc561e0d429dba19e19e18f8bef3", "input": "This study aimed to improve upon our current understanding of the spreading mechanisms of H7N9 and H5N1 by generating spatial risk profiles for each of the two virus subtypes across mainland China.", "output": [ "purpose" ] }, { "id": "task1163-bb075eed17844a5ea103770b5ea0abd4", "input": "apparently immunocompetent dog who initially presented for antibiotic resistant pneumonia.", "output": [ "purpose" ] }, { "id": "task1163-bfe19b7eaed348a4a444d886417a3a3a", "input": "One segment can recombine with another in regions that share little sequence similarity.", "output": [ "background" ] }, { "id": "task1163-a779e5c3611a42b1a070760b97605d64", "input": "regardless of the clinical stage and form of the illness.", "output": [ "finding" ] }, { "id": "task1163-b785c38224d749d59e8f9cf7ecef54f5", "input": "research , and clinical level assays using wild-type Makona-C05 or recombinant virus/antigens from different Ebola virus variants.", "output": [ "background" ] }, { "id": "task1163-5bae102d7c034f63a4238230252e3c9b", "input": "In this study , epigallocatechin gallate ( EGCG ) and EGCG glucoside ( EGCG-G1 ) were identified as inhibitors of HMA by an in vitro assay with IC 50 of 20 ± 1.0 and 31.5 ± 1.0 µM , respectively.", "output": [ "finding" ] }, { "id": "task1163-0e0f6d81a57e4527a8bcb95992bbfea6", "input": "The monthly added cost was $ 16,400 for included infection control items.", "output": [ "finding" ] }, { "id": "task1163-27677b8ae4214173a1f76563c9b99957", "input": "offers new opportunities for future bench-to-bedside research.", "output": [ "background" ] }, { "id": "task1163-1a8aa0bdb4ce469780d52735e220caf3", "input": "envelope ( E ) , membrane ( M ) and nucleocapsid ( N ).", "output": [ "background" ] }, { "id": "task1163-16c3f3eaa6b247ca9e2be0fa6a09bef0", "input": "Study Design-Forty-four nasopharyngeal washes collected during the 2004-05 winter season from pediatric patients with respiratory illnesses that tested negative for 7 common respiratory pathogens by culture and direct immunofluorescence assays were analyzed by MassTag-PCR.", "output": [ "method" ] }, { "id": "task1163-ca67be7ddfc044d2b2b9c43a7f2f7a3c", "input": "there were 149 low-standard HCW disposal facilities in operation in China , distributed throughout different areas.", "output": [ "background" ] }, { "id": "task1163-abfea4cdf2ea497ba0c62d416bd345d8", "input": "Despite intensive ongoing research , key aspects of the spatial-temporal evolution of the 2001 foot and mouth disease ( FMD ) epidemic in Great Britain ( GB ) remain unexplained.", "output": [ "background" ] }, { "id": "task1163-79d8bdacd9b1479cbb36840ba92847e7", "input": "† Scope A brief review of M1 metalloproteases in plants and animals and their roles in the cell cycle is presented.", "output": [ "purpose" ] }, { "id": "task1163-b630cd264fd24469a031afc82c0772a4", "input": "Consensus from these three programs suggested HPRT1 and HMBS could be used as the two most stable reference genes in the present study.", "output": [ "finding" ] }, { "id": "task1163-118620fea88049028642fc10316b9b1f", "input": "and young and adult alpacas.", "output": [ "purpose" ] }, { "id": "task1163-cc57e9a5ad9d4a96b1db233bdd9f6c88", "input": "it should be studied in how far the binding pose and affinity are affected by this chemical modification.", "output": [ "finding" ] }, { "id": "task1163-9b06774b53ac4c1aa242136db7653fd2", "input": "at the 3 end of the genomic RNA of coronavirus mouse hepatitis virus was required for host protein binding and viral RNA synthesis.", "output": [ "background" ] }, { "id": "task1163-14fa1d0bb44d449aa9c6dabd5daf8544", "input": "For over 30 years , HIV/AIDS has wreaked havoc in the world.", "output": [ "background" ] }, { "id": "task1163-98ed1d6f2e4341ffb66f1ab453adb554", "input": "early in the MERS outbreak.", "output": [ "purpose" ] }, { "id": "task1163-58c96ba3b64941d98feab408fe6c6184", "input": "In sum , members of the family Reoviridae have evolved a variety of mechanisms to subvert the host 's innate protective response.", "output": [ "finding" ] }, { "id": "task1163-531e5fbe40d746da8df8285d0f7a97db", "input": "resulting in five infected and four susceptible calves per group.", "output": [ "method" ] }, { "id": "task1163-f7aaf5c11d5f44e0bf887ff8594820a4", "input": "In this article , we present a commentary on how the metagenomics incorporated with microarray and new sequencing techniques are helping microbial detection and characterization.", "output": [ "purpose" ] }, { "id": "task1163-aa89586cb55a40168f1d0cf6e787325f", "input": "with direct contact between animal groups for 24 h as challenge procedure.", "output": [ "method" ] }, { "id": "task1163-bb1bfb758a9847fc885115e0d051f6f5", "input": "Tissues obtained post-mortem from cattle persistently infected with foot-and-mouth disease virus ( FMDV ) were analyzed to characterize the tissue-specific localization of FMDV and partial transcriptome profiles for selected immunoregulatory cytokines.", "output": [ "method" ] }, { "id": "task1163-224aead3e0f845a0a62a2ec194737b48", "input": "and was greatly affected by purchase of livestock.", "output": [ "finding" ] }, { "id": "task1163-1c5452f7e18e414cb28c242cc4e9bd55", "input": "International Journal for Parasitology 18 : 371-377.", "output": [ "background" ] }, { "id": "task1163-d9befb6d505546a4a5515a2e65f7813c", "input": "The copy numbers for transcripts of TGEV and PEDV were quantified using this assay over a range from 9 × 10 7 to 9 × 10 1 copies and 7 × 10 7 to 7 × 10 1 copies , respectively.", "output": [ "background" ] }, { "id": "task1163-9f1304d712764daa85f59ccef53f3369", "input": "RatPyV2 was initially detected in the parotid salivary gland of a colony member.", "output": [ "background" ] }, { "id": "task1163-31561006a02447b0819e67c9a1cc76ab", "input": "In this study , a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area.", "output": [ "purpose" ] }, { "id": "task1163-de02e06645fd4e6d9757be076b826d73", "input": "droplet , or airborne transmission.", "output": [ "background" ] }, { "id": "task1163-f794f48f19bf46bb913932df515bfaf6", "input": "Seasonal hyperacute panuveitis ( SHAPU ) is a potentially blinding ocular disease occurring in Nepal that principally affects young children.", "output": [ "background" ] }, { "id": "task1163-05f0a2ac5e6c425f8bbc0b57f7c410a5", "input": "and serum procalcitonin were obtained in nearly every case.", "output": [ "method" ] }, { "id": "task1163-dff0b2e987de4de09abe750b591c50fc", "input": "The primary and secondary outcomes were the occurrence of symptomatic clinical URTI and laboratory confirmed URTI respectively.", "output": [ "method" ] }, { "id": "task1163-db2f8130aca44a07acd672b7cb310a8d", "input": "restored transport and cleavage of GP-C and maturation of virions.", "output": [ "finding" ] }, { "id": "task1163-aa0e1de52f1042b080f98a8e5a3843d4", "input": "which represents the highest resolution and first non-human IL-2 structure.", "output": [ "background" ] }, { "id": "task1163-684aa6d796534a4888eed96c3017bcc7", "input": "Subjects were excluded if there were any missing data that prevent the final analysis.", "output": [ "method" ] }, { "id": "task1163-08cac4a8958a427bb928e1c89f95d6ef", "input": "The ethical and legal issues surrounding control of a pandemic influenza and the prospect of telemedicine as a form of social distancing are also discussed.", "output": [ "purpose" ] }, { "id": "task1163-c12971eb0cc74e12830a11c265d0d186", "input": "Further rapid progress can therefore be prospected for the next decade.", "output": [ "finding" ] }, { "id": "task1163-e7017f8180b241aba5c702460ece3529", "input": "with particle sizes less than 20 nm by characterization of environmental scanning electron microscope and transmission electron microscope.", "output": [ "method" ] }, { "id": "task1163-23b04cffb9a74c25b428d1b52d58463b", "input": "The candidate with the maximum RRI and proper occurring frequency is potentially the best threshold.", "output": [ "method" ] }, { "id": "task1163-0a4eb3244c654db3bac80132cc4757d5", "input": "response efficacy , and selfefficacy for severe acute respiratory syndrome ( SARS ) and eight other diseases in five European and three Asian countries.", "output": [ "purpose" ] }, { "id": "task1163-cb20dfd1e89e4f36913fae986c5d9797", "input": "including those of the central nervous system ( CNS ).", "output": [ "background" ] }, { "id": "task1163-e698d75e576b4a5d893a8d56109a6ebf", "input": "to the compare efficacy of antiviral prophylaxis to that of the seasonal influenza vaccine and to identify exposures that increase risk of acute respiratory illnesses ( ARI ) in healthy adults.", "output": [ "purpose" ] }, { "id": "task1163-70d7c56d65264333b45fa003090a6d49", "input": "a family of positive-sense single-stranded RNA viruses.", "output": [ "background" ] }, { "id": "task1163-84fc50a2c488427e915d70608e2cf5b0", "input": "11 days after symptom onset.", "output": [ "background" ] }, { "id": "task1163-7799c354f009400da08a4b8a61261d13", "input": "Here , we weigh the economic costs and benefits associated with implementing widespread quarantine in Toronto during the SARS outbreaks of 2003.", "output": [ "purpose" ] }, { "id": "task1163-b0494ff2f3304dae9cb2a8adda27d82e", "input": "Increased expression of IP-10 and I-TAC in the peripheral blood of ten patients at the early onset of fever was confirmed by ELISA.", "output": [ "finding" ] }, { "id": "task1163-31d56d9b4fba4b4390fd4d20a328a9c2", "input": "Methods : The reporting incidence ( RI ) and mortality data on HIV and AIDS in China covering 31 provinces from 2004 to 2014 were collected from the Chinese Public Health Science Data Center.", "output": [ "method" ] }, { "id": "task1163-751c63dd7c95445bb0131392fe0b734b", "input": "All patients had telephoned NHS Direct between 11 and 14 May with concerns about swine flu and had been assessed as being unlikely to have the illness.", "output": [ "method" ] }, { "id": "task1163-008a80adc5c444b5abc7530f192d827c", "input": "LYM % in moderate type of patients with COVID-19 remained higher than 20 % 10-12 days after symptom onset.", "output": [ "finding" ] }, { "id": "task1163-14038a322474447e80ac3d3c78e35d84", "input": "and is significantly larger than 1.", "output": [ "finding" ] }, { "id": "task1163-eda39a6750ee44349a1b95197caad9bc", "input": "resulting in stabilization of IκB and concomitant failure of virus to activate NF-κB for induction of IFN.", "output": [ "finding" ] }, { "id": "task1163-2c4851a77ac44b7a893a2a3c26b87c60", "input": "Hematological and coagulation profiles were studied in crossbred dogs experimentally infected with Angiostrongylus vasorum.", "output": [ "method" ] }, { "id": "task1163-06c83600599940b0ac046c6e9a80cb78", "input": "The other single mutants displayed efficient fusion with the same pH dependence as wt-HA.", "output": [ "finding" ] }, { "id": "task1163-bb42f27ee8584621a5527b37087d7d99", "input": "Four medical and meteorological databases ( Medline , Embase , GeoRef , PubMed ) and a global electronic reporting system ( ProMED ) were searched , from 1910 to 2010.", "output": [ "method" ] }, { "id": "task1163-461c42009dab49e7809bc0e2782828eb", "input": "MVTT-S , however , was capable of inducing consistently 20-to-100-fold higher levels of Nabs than MVA-S when inoculated via either intranasal or intraoral routes.", "output": [ "finding" ] }, { "id": "task1163-4299331839af4b6aac62a805c5b6da1a", "input": "the synthesis of carbasugar analogues of 2-deoxyribose-1phosphate was envisioned.", "output": [ "background" ] }, { "id": "task1163-f60444b0df6045479f4d0d80ba7c04ac", "input": "Furthermore , we discuss strategies for drug development and the limitations of the approaches with respect to HEV.", "output": [ "purpose" ] }, { "id": "task1163-930f62e534174745b6cf4856208ab7b3", "input": "The study provides valuable information with regard to producing scientifically based biosecurity advices.", "output": [ "finding" ] }, { "id": "task1163-273c5734f3114ec3aecbca793828c45a", "input": "medical expenses and patient satisfaction.", "output": [ "purpose" ] }, { "id": "task1163-fe65fbd7a70047b19fc7968a1eeccf65", "input": "The delay between symptom onset and isolation played the largest role in determining whether an outbreak was controllable for lower values of R0.", "output": [ "finding" ] }, { "id": "task1163-38ab7a1797e940c39f066dbac1901564", "input": "The study design was consistent with the NTP 13-week toxicity studies.", "output": [ "method" ] }, { "id": "task1163-adbda21a6e1f41128e1092b0ff88f948", "input": "and detected by flow cytometry.", "output": [ "method" ] }, { "id": "task1163-526847f8f85f4a22b9af66ff5c37ef2c", "input": "In vivo experiments were set up where BALB/c mice were exposed to sublethal doses of Cd or Hg salts for 3 or 5 weeks.", "output": [ "method" ] }, { "id": "task1163-c4a8c94a94564204ade09c3843eef7f0", "input": "In this study , we sought to use this signal transduction conduit against them by inhibiting multiple kinases that influence translation.", "output": [ "purpose" ] }, { "id": "task1163-4553a31fc3604aa0bb75976e3acb6b0d", "input": "clinical outcomes , and treatment safety.", "output": [ "purpose" ] }, { "id": "task1163-6750169bf57248a9bb1df0f0f951c502", "input": "purification and crystallization of nsp10 in complex with nsp16 are reported.", "output": [ "purpose" ] }, { "id": "task1163-dec4f7a2fe8f4b71852eb3962b2690f3", "input": "and fecal samples within 6 h after fieldcollected samples reached the laboratory.", "output": [ "finding" ] }, { "id": "task1163-03c6d5db8c754a5696a7713a73866f88", "input": "we noticed that some fecal viruses generated plaques > 100 times as large as inoculum viruses.", "output": [ "finding" ] }, { "id": "task1163-f5a5b732a7564ec2990cb4c2a0aaeddc", "input": "The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract.", "output": [ "background" ] }, { "id": "task1163-566832da182744c7882f2aee93ad68d1", "input": "including Severe Acute Respiratory Syndrome ( SARS ) and Middle East 50 Respiratory Syndrome ( MERS ) 7.", "output": [ "background" ] }, { "id": "task1163-454f4074016643419e240f53a629a93d", "input": "an d in vivo functions o f the defense agent s in human milk.", "output": [ "purpose" ] }, { "id": "task1163-11123d959818448da7ff43b27bf7a608", "input": "Results : A total of 48 people participated in this study.", "output": [ "finding" ] }, { "id": "task1163-a4ad5e6c36244dbcbb46f1f392abfc7b", "input": "and those that had pasty or firm feces and normal physical examination were designated as controls.", "output": [ "method" ] }, { "id": "task1163-0ea415a4e84c40e3863667f71fcd797d", "input": "This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses ( FMDVs ) and demonstrated that ribavirin showed antiviral effects against FMDV in vitro/in vivo.", "output": [ "method" ] }, { "id": "task1163-f9dd84b736754229ad1a633814ebdcfe", "input": "We also provide an online app so that results can be updated as new information becomes available.", "output": [ "finding" ] }, { "id": "task1163-6bf341cd182347a1b109cc7a41894d73", "input": "In this study , we raised monoclonal antibodies ( mAbs ) against the nucleocapsid ( N ) protein of SARS-CoV and mapped epitopes by using different truncated N protein fragments.", "output": [ "purpose" ] }, { "id": "task1163-ebc71c0f5cb84d77bf17b900720e2697", "input": "Data Synthesis : Out of 1675 non-duplicate studies identified , 57 were included.", "output": [ "method" ] }, { "id": "task1163-2b95d2b2fc3d4fa09ea8cca95ae99d54", "input": "Results of studies from Finland and Germany furthermore showed that biological characteristics of the raccoon dog make this carnivore an ideal host and vector for a variety of pathogens.", "output": [ "finding" ] }, { "id": "task1163-3f12e13c69e0459baab45487d5b5f5af", "input": "a characteristic of HIV-1 infection of the central nervous system ( CNS ).", "output": [ "background" ] }, { "id": "task1163-f1683935f39d41c996eed1294b331acb", "input": "Since then , researchers have conducted numerous in vitro and in vivo studies that consistently confirmed the antidiabetic activity of banaba.", "output": [ "background" ] }, { "id": "task1163-27427a476e6447dda939daf0b10a03ed", "input": "Both community-acquired and hospital-acquired cases have been reported with little human-to-human transmission reported in the community.", "output": [ "background" ] }, { "id": "task1163-8decad483b72465e88e4c293a763319d", "input": "ELISA would seem most applicable for screening other lower vertebrates for anti-parasite antibodies especially in areas of human disease prevalence.", "output": [ "finding" ] }, { "id": "task1163-cb96ba12d48b4d41bac522b3c9ec2f83", "input": "Methods : Two experimental mouse models that mice hydrodynamic injected HBV DNA or infected with recombinant AAV/HBV were used.", "output": [ "method" ] }, { "id": "task1163-730756de383d48efba98e615737252c8", "input": "Non-encapsidated , unusual viral RNA harboring the 5 - terminal region of the viral genome as well as RIG-I and typical SG markers accumulated in these granules.", "output": [ "finding" ] }, { "id": "task1163-8b20c6c6e4bc40b7b27c882561730420", "input": "Furthermore , specifi c anti-microbial antibodies can be produced into colostrum by immunizing cows with vaccines made of pathogenic microorganisms.", "output": [ "background" ] }, { "id": "task1163-4ea1d5da91464ad9a8de58dc39e35bdd", "input": "the lung volume recovery was significantly reduced in KO mice compared to WT.", "output": [ "finding" ] }, { "id": "task1163-67b36f0b923f49f6ae8a64a17f4a2f13", "input": "In-hospital mortality decreased from 59.7 % in 1997 to 47.5 % in 2011 ( P < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-ef46886000f1476581395df3b78074d3", "input": "Blood was collected at 21 dpv for serology.", "output": [ "method" ] }, { "id": "task1163-bf2e9c7da64541b6a660337bd79f0496", "input": "We aimed to determine the proportion of subjects with pathologic chest radio graphic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis.", "output": [ "purpose" ] }, { "id": "task1163-4967553dafb7412b87aa591d5fe413e4", "input": "Exploring the molecular mechanisms that prevent inflammation during caloric restriction may yield promising new therapeutic targets.", "output": [ "background" ] }, { "id": "task1163-0bbfa11868944b61a9d4eb2cc03d2663", "input": "indicating that the C-terminal domain of GP4 functions as a GPI anchor.", "output": [ "method" ] }, { "id": "task1163-fc99ba743c4a43e090ba95a7f6d65350", "input": "thereby creating a more humane food production industry.", "output": [ "purpose" ] }, { "id": "task1163-e1dc36cc4175453ab22b619f07bd7b15", "input": "A new scorpion venom peptide derivative Kn2-7 was identified as the most potent anti-HIV-1 peptide by screening assays with an EC 50 value of 2.76 mg/ml ( 1.65 mM ) and showed low cytotoxicity to host cells with a selective index ( SI ) of 13.93.", "output": [ "finding" ] }, { "id": "task1163-52ab23a95d844e0ca93c9e74515ed264", "input": "and 1.7 million die from this curable disease.", "output": [ "background" ] }, { "id": "task1163-2c34c658a52240c2aaf70bfbae97c7de", "input": "Background : Equine coronavirus ( ECoV ) is considered to be a diarrheic pathogen in foals.", "output": [ "background" ] }, { "id": "task1163-4e25a7d69b6b4576a32deec35ca60885", "input": "Prior to EMS calls , 2 surfaces were seeded with FX174.", "output": [ "method" ] }, { "id": "task1163-5b2865d832624fbab1a28d4e4751c1be", "input": "The worldwide spread of the third pandemic began when the plague reached Hong Kong and Canton in the year 1894.", "output": [ "background" ] }, { "id": "task1163-510769fa3d464756a62c3c8c53e2d02c", "input": "It remains to be shown how such a restricted infection leads to demyelination.", "output": [ "background" ] }, { "id": "task1163-e060e6ec3f074cf896620c5dce72581a", "input": "Results : Some surveillance systemsespecially ad hoc systems developed in response to the pandemic flu outbreakare more correlated with the information environment than others.", "output": [ "finding" ] }, { "id": "task1163-1efb16e647ef433f8cf1cae7395c90fc", "input": "an antiviral drug exhibiting roughly similar polymorph-dependent crystallization kinetics in melts to that of salmeterol xinafoate.", "output": [ "purpose" ] }, { "id": "task1163-f09c0075e5fd47ef815f949ed996a170", "input": "Virus pseudotyped with Nipah virus glycoproteins bound heparan sulfate and heparin but no other glycosaminoglycans in a surface plasmon resonance assay.", "output": [ "finding" ] }, { "id": "task1163-c114f4420cca4d8eb5ec4b4610d58b44", "input": "but also other iridoviruses infecting ectotherms.", "output": [ "purpose" ] }, { "id": "task1163-d81b1481b05b4195a605112ab2412576", "input": "Here we will address our current understanding of the role of viruses as potential environmental triggers for MS. Virus infections can act peripherally ( outside the CNS ) or within the CNS.", "output": [ "purpose" ] }, { "id": "task1163-1c92a7a7630f40e986daae8b7d2c356e", "input": "In the latter , mounting evidence indicates their key biological activity.", "output": [ "background" ] }, { "id": "task1163-2e69ea33230f4313b5898332c830bfda", "input": "phagocytic and bactericidal activity , and kinetics of peripheral blood mononuclear cells ( PBMC ) and splenocytes.", "output": [ "purpose" ] }, { "id": "task1163-950e7d6f91c7414ca2c498cd26904e42", "input": "The main objectives of this study were to evaluate effects of a prebiotic supplement containing fermentation products of lactic acid bacteria on the mucosal immune system by measuring fecal and salivary IgA and to evaluate calf health and growth performance.", "output": [ "purpose" ] }, { "id": "task1163-65ab6ffd6f30432492b2c6c1a422b8fd", "input": "They infect humans as well as numerous mammalian species.", "output": [ "background" ] }, { "id": "task1163-2295312d59f947529d94c80705f59ba6", "input": "The adjusted median G6PD value of males in the study population was used to define various cut-off points according to the WHO classification guidelines.", "output": [ "method" ] }, { "id": "task1163-92a0398d56a64a0e8d5dac2f518298b7", "input": "we here present a comprehensive analysis of putative G-quadruplexes in the genome of all known viruses that can infect humans.", "output": [ "purpose" ] }, { "id": "task1163-ab3fbf8bcd4240ea97ace4cd83756ade", "input": "two species previously described from Australian bats.", "output": [ "method" ] }, { "id": "task1163-863325448a314d05b857a286091b5fe2", "input": "and 4 ) placebo and no gargling.", "output": [ "method" ] }, { "id": "task1163-1aa9f80648b344f0aed45b1b90ab50a7", "input": "All records were screened against the protocol eligibility criteria , using a 3-stage process.", "output": [ "method" ] }, { "id": "task1163-22c4f039e81340f38305f4e9f1bf0874", "input": "peripheral blood sample was taken for testing the VBG parameters and the anion gap ( AG ) was calculated.", "output": [ "method" ] }, { "id": "task1163-0e4755fd411e46a5875a17141dc8f2a0", "input": "' and the goal of achieving real time research problem solving capacity in disaster crisis situations.", "output": [ "finding" ] }, { "id": "task1163-42bf2dbd64dd4c7aa2f2e52819d36efd", "input": "and circovirus ( 1-5 ).", "output": [ "method" ] }, { "id": "task1163-072264ba21b24b6f8e8eabcc85cee2d6", "input": "List all legislative and administrative documents that address the legal aspects of the unlawful use of biological agents.", "output": [ "purpose" ] }, { "id": "task1163-fc86b8f2a4494b5ca8cf1254581826c4", "input": "In five multicat households , 29 cats naturally infected with FCoV and actively shedding virus in the faeces were given Mutian X pills.", "output": [ "method" ] }, { "id": "task1163-64242b2682244420ac8fb0adc3121737", "input": "The primary focus of this chapter is the application of methods based on 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] }, { "id": "task1163-e3100145a90a4275938a2eab1993b077", "input": "and AMI ( n = 6 ).", "output": [ "finding" ] }, { "id": "task1163-cdc730bb9b1c49febb4efc7b82e800c5", "input": "Canine distemper virus ( CDV ) is the cause of a severe and highly contagious disease in dogs.", "output": [ "background" ] }, { "id": "task1163-044a25f6b00244f2a84149bc797139f8", "input": "gp41 plays a significant role in the membrane fusion and virus entry of HIV-1 1,2.", "output": [ "finding" ] }, { "id": "task1163-672ea4c8493e4193a6a08b473294ef06", "input": "low-volume and easy-to-use pointof-care ( POC ) diagnostic devices that can be adapted or commercialized for real world applications.", "output": [ "finding" ] }, { "id": "task1163-fcd619559ac94536bb6dc1cb2285c14b", "input": "• Study the effect of the location of initial infection node on epidemic spreading.", "output": [ "purpose" ] }, { "id": "task1163-2ac2f9885c754556aac831832feb5455", "input": "We used unbiased shotgun sequencing to discover a 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virus ( RSV ) ).", "output": [ "method" ] }, { "id": "task1163-64017cea839242148fc5dafa0ecaecb1", "input": "These results provide examples of how NMR spectroscopy can be used to screen compounds for fast evaluation of enzyme-inhibitor interactions in order to facilitate lead compound identification and subsequent structural studies.", "output": [ "finding" ] }, { "id": "task1163-bc4fcb195a0840c4bdf8e8d1e35569ea", "input": "This article provides clinically relevant information that may aid the clinician in the accurate and prompt recognition of these challenging diseases.", "output": [ "purpose" ] }, { "id": "task1163-15817317ab0d4a82bf107ec105badd62", "input": "This study demonstrates that Tc-bovines can produce pathogen-specific human Ig to prevent and/or treat patients when an emerging infectious disease either threatens to or becomes an epidemic.", "output": [ "finding" ] }, { "id": "task1163-7ef6c186ab5947eda78ccb5119fb9043", "input": "respectively , were diagnosed with severe diarrhea ( fecal score = 3 ).", "output": [ "finding" ] }, { "id": "task1163-d759584cf9544ff8be3affdaaa1a8bb7", "input": "but primary in enforcement of existing rules and stimulating responsible pet-ownership.", "output": [ "finding" ] }, { "id": "task1163-23a10a9268cf41ae8f8d55c545722969", "input": "especially for the throat swabs group at the later stage of illness.", "output": [ "finding" ] }, { "id": "task1163-4b0215250f09429cb49ca6badbb80125", "input": "We hypothesized that while asymptomatic carriage would not increase the risk of chronic lung allograft dysfunction ( CLAD ) and graft loss , severe infection would.", "output": [ "purpose" ] }, { "id": "task1163-96b2d8832a6444e08455760d33f02995", "input": "forming the tip of a β-barrel , to recognize pAPN.", "output": [ "finding" ] }, { "id": "task1163-e97ed6fab18a4a8b9c91682b3a47a418", "input": "Animals were classified into two groups depending on their initial BCoV IgG1 Ab titers.", "output": [ "method" ] }, { "id": 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the pathogenic mechanisms of enteroviruses and provide a potential strategy for the treatment and prevention of EV-D68-related disease.", "output": [ "finding" ] }, { "id": "task1163-9dd555de9fb3426aa4145483dda259f8", "input": "These examples indicate that zoonotic risks in the livestock industry should be carefully managed and adapted to livestock intensification.", "output": [ "background" ] }, { "id": "task1163-11118ff7bb5140dabe195dcb2dd2ac98", "input": "1,966 were antisense , and 249 were intragenic lncRNAs.", "output": [ "finding" ] }, { "id": "task1163-e0b265b4079848ea889050380ae27916", "input": "Members of the public were approached in shopping and pedestrian malls to undertake the survey during September and October 2009.", "output": [ "method" ] }, { "id": "task1163-cc8b8834c0e147cbabdb4908119e02d5", "input": "Plant molecular pharming has emerged as a reliable platform for recombinant protein expression providing a safe and low-cost alternative to bacterial and mammalian cellsbased systems.", "output": [ "background" ] }, { "id": "task1163-ca86e88be9724d43bf4c1ee6927d4843", "input": "and the HSV1-APOE-ε4 association in AD.", "output": [ "background" ] }, { "id": "task1163-25c5ffd23d7d4bae8cd0539affce7674", "input": "but it is not clear how this benefits the virus or the host.", "output": [ "background" ] }, { "id": "task1163-a68cef95ea29410da3548d6ee155fedc", "input": "The quantifiable proteome was annotated using bioinformatics.", "output": [ "method" ] }, { "id": "task1163-10ac81489e1042ef9990027b1110f803", "input": "with a specific focus on how they relate to infectious disease.", "output": [ "purpose" ] }, { "id": "task1163-639ebc351a32415a834e2415496ae0b6", "input": "and then the liver preparations from both infected and non-infected animals were subjected to two-dimensional gel electrophoresis.", "output": [ "method" ] }, { "id": "task1163-5363a201fedc44ba8c855ef03d3fe4bd", "input": "Systemic solicited events were similar between placebo and VLP 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0.03 ).", "output": [ "finding" ] }, { "id": "task1163-e55ff56253e540438522533ec6fd388e", "input": "In this study , we investigated the roles and regulation of reactive oxygen species ( ROS ) in TGEV-activated apoptotic signaling.", "output": [ "purpose" ] }, { "id": "task1163-8fcadc97ad1040a5897c46a1d22052bb", "input": "compared with saline-injected control tissues.", "output": [ "finding" ] }, { "id": "task1163-929c1c3ad8ea4bde8f0949a6fe842f3b", "input": "active immunization against hepatitis B virus ( HBV ) might initiate effective host immune responses versus HBV to achieve functional cure of CHB.", "output": [ "background" ] }, { "id": "task1163-98f0bebc04164963b93f361b494a7c8f", "input": "cloned and expressed as a full-length IgG transiently in 293 T cells.", "output": [ "method" ] }, { "id": "task1163-67c22443cc0f4aeda981e185ab6931b6", "input": "and all 180 sera negative for NT antibody were negative for IP antibody in the healthy dogs.", "output": [ "method" ] }, { "id": "task1163-00e1520ae22c4534a1ebf7b76db6947d", "input": "( iii ) One early ( May 2009 ) and one late ( July 2009 ) viral isolates were characterized by sequencing the complete hemagglutinine and neuraminidase genes.", "output": [ "method" ] }, { "id": "task1163-15f6bbb1f4e5421991e1c60aa7f92af4", "input": "We explore the rationales that have perpetuated this inability or unwillingness to match need with effort.", "output": [ "method" ] }, { "id": "task1163-ab8006d9ca7a4718b6e5bccdcfb92492", "input": "and crashes happened in Apr 2008 triggered by the Subprime Mortgage Crisis of US.", "output": [ "finding" ] }, { "id": "task1163-74a9a32ed0114fa482e2936216f96f4e", "input": "having a > 3 cycle-threshold ( Ct ) difference to that of the expected value by EHV real-time PCR 43 assays was considered to have failed quality control and the sample was re-extracted.", "output": [ "method" ] }, { "id": "task1163-7adb685ce06f44f58d98279ba563a8a8", "input": "Our findings indicate the potential of 2019-nCoV to cause outbreaks.", "output": [ "finding" ] }, { "id": "task1163-bdb846f92b644fb1bbb6a6bb7e756015", "input": "authors presented a novel parallel structural dsDNA/recombinant azurin ( PSD/rAzu ) hybrid structure for the general nucleic acid detection.", "output": [ "background" ] }, { "id": "task1163-f133f47021dd471d9d44c7a980fdfeb2", "input": "and after implementation of the intervention.", "output": [ "method" ] }, { "id": "task1163-88b9a9bb8b86468b97db815646528a08", "input": "We here report a simple and label-free approach via homobifunctional imidoesters ( HIs ) with a microfluidic platform ( SLIM ) to efficiently enrich and extract pathogens at low concentrations from clinical samples.", "output": [ "purpose" ] }, { "id": "task1163-28d3b464632f47e78199a5126fe32bbf", "input": "There is an urgent need to establish an effective and unbiased method to evaluate and monitor such contamination.", "output": [ "background" ] }, { "id": "task1163-6ca81b19fe0a40daaed691c5fd56dbf0", "input": "community-based , birth cohort study conducted between September 2010 and October 2014.", "output": [ "method" ] }, { "id": "task1163-324316aab68d47b0a9470e15698d5d9f", "input": "Reducing pandemic-related stress may best be accomplished through interventions designed to enhance resilience in psychologically healthy people.", "output": [ "background" ] }, { "id": "task1163-4a1440620b984c1fbb2741c530dfdd2c", "input": "RBD promote viral entry into the host cells and is an important therapeutic target.", "output": [ "background" ] }, { "id": "task1163-9d7ac928f3804a80bf5423ec0af1f351", "input": "sensitive , and specific assay that allows for its detection and quantitation in a time-and cost-effective manner.", "output": [ "background" ] }, { "id": "task1163-fd471aac4b844cb1b31287cb95465cd6", "input": "The codon usage patterns always represent balance between the directional mutation and the neutral selection that leads to translational efficiency of genes ( 8 ) ( 9 ) ( 10 ) ( 11 ).", "output": [ "background" ] }, { "id": "task1163-b005c8994652443e9738ed20b0da6650", "input": "consisting of the founders and recombinant progeny of the `` Collaborative Cross '' project.", "output": [ "method" ] }, { "id": "task1163-0f9fab086c184b1891dc7ec87666b65f", "input": "In this study , we developed a Vero cell line that stably expresses PEDV ORF3 gene.", "output": [ "purpose" ] }, { "id": "task1163-6d350d6cba704e39a5ccfada2e15817a", "input": "long-term survival , and health care costs is an acute exacerbation of COPD.", "output": [ "background" ] }, { "id": "task1163-7980b49d7e6945d4ad63b35aa8e31c48", "input": "but an inconspicuous one was found between the PNS-and CNS-type fibre areas.", "output": [ "finding" ] }, { "id": "task1163-fce820853b944eb9af53417c42b848e2", "input": "during and 2000USA , during -2006.", "output": [ "purpose" ] }, { "id": "task1163-6e516956801649e7970bc1ada9205f66", "input": "however virus isolation was unsuccessful from day six and day 18 from the two calves investigated.", "output": [ "finding" ] }, { "id": "task1163-e5b0ffe647da4a479f5dd26e85d5bce6", "input": "H5N1-induced pro-inflammatory responses , and H5N1-induced apoptosis in human monocyte-derived macrophages.", "output": [ "purpose" ] }, { "id": "task1163-c34731cdf0ba452db0849c4e9d04baff", "input": "Histologically , the infection resulted in lung lesions consistent with bronchointerstitial pneumonia of varying severity and nasal turbinates with blunting or loss of cilia of the epithelium lining the nasal septa.", "output": [ "finding" ] }, { "id": "task1163-b9a5fbc6abd5485c8e5719e1cba247c2", "input": "cccDNA and secreted HBsAg were diminished when CRTC1 was compromised.", "output": [ "finding" ] }, { "id": "task1163-38dc17399b1044f7b38007473d80f80f", "input": "This study was designed to determine whether S gene mutation analysis can reliably diagnose FIP.", "output": [ "purpose" ] }, { "id": "task1163-4bed3c53e75c4b298f8f7f0ccbff05b6", "input": "rather than promotes , EV-A71 viral replication.", "output": [ "finding" ] }, { "id": "task1163-24b1c125a9e847209ab690ec97bdebb6", "input": "Moreover , most of these cases with undetectable viral RNA in throat swabs specimens at the early stage of illness were able to be IgM/IgG seropositive after 7 days.", "output": [ "finding" ] }, { "id": "task1163-7f8315d38c764c5698439f296d7755da", "input": "as determined from city-level mortality data ( see Supplementary Information ).", "output": [ "method" ] }, { "id": "task1163-684fec10534940699a541de02d1b763b", "input": "We have examined the requirement for ribonucleotides and ribonucleotide triphosphate hydrolysis during early events in the membrane integration of two membrane proteins : the G protein of vesicular stomatitis virus and the hemagglutinin-neuraminidase ( HN ) glycoprotein of Newcastle disease virus.", "output": [ "purpose" ] }, { "id": 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recommendations for improving the communication about unknown aspects of disease during public health crises.", "output": [ "purpose" ] }, { "id": "task1163-51c115b23c6b4ccc939cb228adc239bc", "input": "including nitric oxide ( NO ).", "output": [ "purpose" ] }, { "id": "task1163-b1eb7c80cec447f397c047ef0e58f97e", "input": "Microbes and microbial products can directly interact with viral particles.", "output": [ "background" ] }, { "id": "task1163-5e3bbd59a2cf437eaa8fd8c5e1f48f49", "input": "We retrieved 12 peptides based on the highest score for human leukocyte antigen ( HLA ) supertypes analysed by NetCTL.", "output": [ "method" ] }, { "id": "task1163-ac0aaf2f19a6452aaf621df0c0bfcd3f", "input": "A total of 29 faecal samples collected from dogs with diarrhoea following canine parvovirus ( CPV ) vaccination were tested by minor groove binder ( MGB ) probe assays for discrimination between CPV vaccine and field strains and by diagnostic tests for detection of other canine pathogens.", "output": [ "background" ] }, { "id": "task1163-68dddd4709c949bd9e8ac04fa88675c6", "input": "We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine.", "output": [ "purpose" ] }, { "id": "task1163-24804c0cd3e64f0b85225136b88995b7", "input": "high resolution structural studies using X-ray crystallography and more recently cryo-EM techniques have provided a wealth of information on structures of variety of viruses.", "output": [ "background" ] }, { "id": "task1163-a75cefa2d62b48adbdfe0b5bd0a499c0", "input": "Finally , the transport of plasmid DNA vaccines into the lungs is reviewed.", "output": [ "method" ] }, { "id": "task1163-581da076c74349b28b656ad88d924f43", "input": "' % I-labeled 68K '' '' was rapidly released into the media of tumor cell cultures and was recovered both in the form of a soluble protein and in a 100 , OOOg pellet.", "output": [ "finding" ] }, { "id": "task1163-99c1c14432b1493d8d10d7b178798bfe", "input": "Our work reveals an essential role of CRTC1 coactivator in facilitating and supporting HBV transcription and replication.", "output": [ "finding" ] }, { "id": "task1163-7fe7153bda45449fb0459f52e37ce1f3", "input": "nsp2 , and 3a , by gene scrambling to prevent the rescue of a virulent phenotype by recombination or remodeling of vaccine genomes based on codon deoptimization using synthetic biology.", "output": [ "finding" ] }, { "id": "task1163-159bcb99217042fa93598e308b3f5992", "input": "including ATP-binding cassette transporter A1 ( ABCA1 ).", "output": [ "background" ] }, { "id": "task1163-205bd67646f54620bef1830cb9fe6080", "input": "Ad12 replicates in human cells but undergoes a completely abortive cycle in Syrian hamster cells.", "output": [ "background" ] }, { "id": "task1163-b20b849e893c423cb9e5852609f59ac2", "input": "The recombinant DENV1 virus was recognized and neutralized by the DENV4 type-specific 5H2 MAb.", "output": [ "finding" ] }, { "id": "task1163-c75a8744716b4e17b271f20d4473ce50", "input": "into milk is not reduced.", "output": [ "method" ] }, { "id": "task1163-598ae6bd22c243088c2a885e13b68d2d", "input": "although no viral proteins can be found in these cells.", "output": [ "background" ] }, { "id": "task1163-b0fc27c844d948fb943baa7467d850c6", "input": "depending on the specific chemistry of the photosensitizing agent and its environment ( 16 ).", "output": [ "finding" ] }, { "id": "task1163-2b1e01f544604c67b693bd61784e05ed", "input": "In this survey we draw attention to the many infective agents which have to be considered in the investigation of cases and outbreaks of gastroenteritis.", "output": [ "finding" ] }, { "id": "task1163-3e29aa71cf73463f9e6722e883c4349c", "input": "It will build up a new foundation for further study on Polygonum multiflorum.", "output": [ "purpose" ] }, { "id": "task1163-33db03a4cd3546e9b6417491a28ff6e2", "input": "We used qualitative interviews to identify the main reasons why people approached NHS Direct with concerns about swine flu and to identify aspects of their contact which were reassuring , using a framework approach.", "output": [ "purpose" ] }, { "id": "task1163-3e4a9d944e44424db7d81beb24d521e7", "input": "and the coronaviruses that are the causes of severe acute respiratory syndrome ( SARS ) and Middle East respiratory syndrome ( MERS ).", "output": [ "purpose" ] }, { "id": "task1163-97568d7b31214646b97de471614d8c10", "input": "through a polyethylene tube 2 mm in diameter in contact with the dura.", "output": [ "background" ] }, { "id": "task1163-a868c2434e5e428b917025f314ce8f36", "input": "Nucleocapsid protein , Spike glycoprotein , and Membrane protein.", "output": [ "finding" ] }, { "id": "task1163-5baaf117586c4c208c81e66eb15fe7fd", "input": "three died , two remain hospitalized.", "output": [ "finding" ] }, { "id": "task1163-ab60f705924a4e22bcc3a7a993ab882d", "input": "Escherichia coli super-shedding and super-spreading by cattle are shaped by microorganism-specific , cattle-specific and environmental factors.", "output": [ "purpose" ] }, { "id": "task1163-9e6c142b564842df8d6c0a6b0e0322f8", "input": "however after cholesterol replenishment virus entry and subsequent replication rates were similar to the control infection.", "output": [ "finding" ] }, { "id": "task1163-ce94f957170c45d1ac9815ba8cf5539c", "input": "we will try to predict the epidemic characteristics only in this area.", "output": [ "purpose" ] }, { "id": "task1163-468db5e41b3b46dea8de1290d0e40e0d", "input": "Cercariae are also able to penetrate human skin and induce cercarial dermatitis.", "output": [ "background" ] }, { "id": "task1163-42ea3a9b85d64dd48b48d6131d602311", "input": "this can enable future allocation of a premium for different view obstruction levels for stakeholders.", "output": [ "finding" ] }, { "id": "task1163-13e05cfe8b0d49c084a673dfffcf15a7", "input": "The influence of CD25 + CD4 + regulatory T cells ( Treg ) on acute and chronic viral infection of the central nervous system ( CNS ) was examined using a glial tropic murine coronavirus.", "output": [ "method" ] }, { "id": "task1163-9a09b766eafc428dbd32ef44993c762b", "input": "However , this term only retrieved 25 % of the top 100 articles.", "output": [ "finding" ] }, { "id": "task1163-87ec20f06bbd49d9b545a4f4e9a8d03c", "input": "which employs a probabilistic heuristic and uses the dominance property to further prune the search space.", "output": [ "purpose" ] }, { "id": "task1163-279c2abbd3a340b0a5e2c9289ef43221", "input": "The human-animal interface has most likely contributed significantly to the evolutionary shaping and historical development of our species.", "output": [ "finding" ] }, { "id": "task1163-da46fdaf51f74f48bde8cf1e25ac80fa", "input": "from 1985 to 2017 , were analyzed.", "output": [ "method" ] }, { "id": "task1163-a1208fc9f1d44da2a6080ef7ab99de74", "input": "as well as B. bronchiseptica and Mycoplasma spp. were analyzed in respiratory samples using PCR assays.", "output": [ "method" ] }, { "id": "task1163-4925159448b041a7b157c2a6c5fcf37d", "input": "a bio-informatics approach was used for analysis of codon adaptation biases.", "output": [ "method" ] }, { "id": "task1163-0c850ed466244e7a9cec9fd9344965fd", "input": "including the thematic of urban health.", "output": [ "background" ] }, { "id": "task1163-5875e6daa74c449e81b4a3dbe2740bea", "input": "Symptomatic students also completed an electronic symptom diary.", "output": [ "method" ] }, { "id": "task1163-56f47a8384dc43d580163bf3ff799045", "input": "in addition to using their own in-house database.", "output": [ "method" ] }, { "id": "task1163-650ac4e086554b5bba64567afe147991", "input": "and heat-related emergency visits were evaluated.", "output": [ "method" ] }, { "id": "task1163-fab63fae0a674758ab0594cc93fd5625", "input": "The completeness of reporting varied among the health care systems from 2 % to 30 % and improved over time.", "output": [ "finding" ] }, { "id": "task1163-fbae9ddfb48343b9b5175a80c3cb5a80", "input": "Both SAFV-3 isolates had neurotropism and mild neurovirulence but showed different cell tropisms in both neonatal and young mouse models.", "output": [ "finding" ] }, { "id": "task1163-11e200556f4b4b62ae29520cbfce0e95", "input": "particularly when applied to humans.", "output": [ "background" ] }, { "id": "task1163-33ff2079b34f4de78ffcadf8e980a065", "input": "recently emerging as an important modulator of inflammation.", "output": [ "background" ] }, { "id": "task1163-4804a0e0a65743ecaf86724f2832d77b", "input": "Herein , we report three highly conserved G-quadruplex motifs ( SE-PGQ -1 , 2 , and3 ) in genome of all the 412 strains of Salmonella enterica.", "output": [ "purpose" ] }, { "id": "task1163-3d1fe2e9f7734b548d4397cf6bcd73a9", "input": "when he developed severe non-bloody diarrhea , approximately 20 times daily.", "output": [ "background" ] }, { "id": "task1163-6a514e35753a4509851cf54a4bc758ad", "input": "Junctional adhesion molecule-A ( JAM-A ) is a member of the immunoglobulin superfamily expressed in tight junctions and on hematopoietic cells that serves as a receptor for all reovirus serotypes.", "output": [ "finding" ] }, { "id": "task1163-cd96e4577abe43d7876c8bdb7029aefc", "input": "given that it results in significant morbidity and mortality in neonatal piglets and is associated with increased costs related to vaccination and disinfection.", "output": [ "background" ] }, { "id": "task1163-a599e16be6ca41858feb1f8e7110632b", "input": "designated as SAT05f , has been studied for its capacity of negatively regulating innate immunity induced by TLR7/TLR9 agonists in vitro and in mice.", "output": [ "background" ] }, { "id": "task1163-60bd5a7bd8324161ba7148f08c13ef2b", "input": "Human coronaviruses are one of the main causes of upper respiratory tract infections in humans.", "output": [ "background" ] }, { "id": "task1163-6571ee17e25b41cab0b9a49eb2a4dec0", "input": "so is the availability of long-term datasets that could serve to enhance public health surveillance.", "output": [ "background" ] }, { "id": "task1163-915e3ea403bd43edb303a81367001ff7", "input": "and educational research are discussed.", "output": [ "purpose" ] }, { "id": "task1163-d7781debdd1843708d6f1fd48d1aaf7a", "input": "enveloped viruses , by interfering with endosomal fusion.", "output": [ "background" ] }, { "id": "task1163-43f749b04c76478f94f49de0d90925e4", "input": "one of the best studied at the molecular level is the evolutionarily conserved TRAPP complex.", "output": [ "background" ] }, { "id": "task1163-d17715e4e9664c55818e01196f7b1cfc", "input": "whereas those included in the category of common conditions were considered to be of lower adaptive value.", "output": [ "method" ] }, { "id": "task1163-4d5f2635af414644a3ee6e7f116945c3", "input": "and infectious diseases ( 53-64 ) ; immune disorders ( 65-69 ) ; diabetes ( 70 -72 ) ; and hereditary diseases ( 73-77 ).", "output": [ "purpose" ] }, { "id": "task1163-645068c2a18d4b7586c22830bc0b6814", "input": "This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins ( RNPs ).", "output": [ "purpose" ] }, { "id": "task1163-e580ecb8b3d64b25a4a241106d4f6a79", "input": "self-protection and laissez faire , and could adjust their strategies according to their neighbors ' strategies and payoffs at the beginning of each new season of epidemic spreading.", "output": [ "method" ] }, { "id": "task1163-81cba74c5f4941738117ff0c6ddd5d2f", "input": "We retrieved sequence data on seven fully sequenced coronaviruses and identified the main 3CL proteinase cleavage sites in polyproteins using alignments.", "output": [ "method" ] }, { "id": "task1163-66daa23f7c63407b957d3662ddc06485", "input": "Conclusions : K-601 has proven anti-inflammatory and antipyretic actions.", "output": [ "finding" ] }, { "id": "task1163-0940049b802748dc87cd876974e90a30", "input": "and ( 3 ) the potential for inhalation of such droplets or droplet nuclei by a susceptible host.", "output": [ "purpose" ] }, { "id": "task1163-524f4555e50f485aa4516052d12dfd44", "input": "Routine viral culture and multiplex PCR were inadequate methods to identify EV-D68 due to poor sensitivity and inability to differentiate EV-D68 from other enterovirus serotypes or rhinovirus.", "output": [ "finding" ] }, { "id": "task1163-58962ebf222b43ebb1099a5e2c79c926", "input": "Objective-To develop a method to perform multiple tests on single nasopharyngeal ( NP ) swab.", "output": [ "purpose" ] }, { "id": "task1163-0aade1e65640480f9c9e2715751feb02", "input": "In the present study , we report the discovery of bat CoV genes in Indonesian Moluccan naked-backed fruit bats ( Dobsonia moluccensis ).", "output": [ "purpose" ] }, { "id": "task1163-38126cd7ba5848c7bf261aba190cc16a", "input": "We studied the infection control influence of MERS-CoV using a hospital-based analysis.", "output": [ "purpose" ] }, { "id": "task1163-0160913def3b4105adf51092f2799897", "input": "and to determine the association between pathogens and the markers of asthma activity.", "output": [ "purpose" ] }, { "id": "task1163-db6ea92094c54cd2b36e7c5880fe2469", "input": "modern vaccination and therapeutic strategies with thrust on T cell biology.", "output": [ "purpose" ] }, { "id": "task1163-936bb228d5b14044bbe105cc9d36f6bd", "input": "abdominal pain , rash , or dysuria.", "output": [ "background" ] }, { "id": "task1163-388b6bb432a6429a9315e2fc4d96f6a9", "input": "Within this review we explore examples and applications of oligonucleotide functionalised microbeads in aptamer selection and reflect upon new opportunities arising for aptamer science.", "output": [ "purpose" ] }, { "id": "task1163-d2f3a94b0b9f4537a19135b951954093", "input": "To assess preventive effects of meditation and exercise on acute respiratory infection ( ARI ) illness.", "output": [ "purpose" ] }, { "id": "task1163-960a6907d4064ac796f7072e98506f80", "input": "the leading cause of acquired heart disease in children , is currently unknown.", "output": [ "background" ] }, { "id": "task1163-a01c41c7f9f04fe6a192100afb648e39", "input": "We compared innate and adaptive immune responses of two patients infected with MERS-CoV to understand the underlying mechanisms involved in the response and propose potential therapeutic approaches.", "output": [ "purpose" ] }, { "id": "task1163-8a0c66321c73445f886746e1458d63fa", "input": "specifically those based on the thickness shear mode ( TSM ) resonator.", "output": [ "purpose" ] }, { "id": "task1163-4c8d7930c08345d6acf65bbeedf08c47", "input": "have mild disease , or have a life-threatening infection with a high case fatality rate.", "output": [ "background" ] }, { "id": "task1163-430888654eab43b5af377247d47daad7", "input": "2019 , in Wuhan , China.", "output": [ "background" ] }, { "id": "task1163-f92ffad5affb42419d93b1dfe509c2f7", "input": "and may aid our understanding of disease emergence in natural populations of bats.", "output": [ "finding" ] }, { "id": "task1163-4c463fb3d7304b9fbbdbb235db2417f0", "input": "Under the One-health platforms there is a need to launch combined human and animal RVC surveillance programs for a better understanding of the epidemiology of RVC infections and for implementing control strategies.", "output": [ "finding" ] }, { "id": "task1163-ad1a10647a154e45aa4deef55335a49d", "input": "The study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and selected randomized control trials which compared the efficacy of glucocorticoids add-on to macrolide in the treatment of MRMP in children.", "output": [ "method" ] }, { "id": "task1163-ec9b0e80ff124d8a83e38961b29cba6f", "input": "0 5 0 - oligoadenylate ( 2-5A ) second messengers and which impedes viral infections in higher vertebrates.", "output": [ "background" ] }, { "id": "task1163-562d6a5dc9724ba695fb4b7be7751ec1", "input": "and ( ii ) analyze the possibly related risk factors.", "output": [ "purpose" ] }, { "id": "task1163-2edb209b63f1486d887fe85567087a47", "input": "rapamycin , potently inhibited both experimental and patient-derived rotavirus strains.", "output": [ "finding" ] }, { "id": "task1163-96726b0f258549dc8a3ab833562ea7d8", "input": "they share onlỹ 55 % nucleotide identity.", "output": [ "finding" ] }, { "id": "task1163-4eac0e68d79a49e69ccdd32a9aacd67e", "input": "with the N-terminus exposed luminally and the C-terminus exposed cytoplasmically ( N exo ( lum ) - C cyto ).", "output": [ "finding" ] }, { "id": "task1163-901e7be8762d44d1bc3e9ce8e6934667", "input": "and this knowledge has the potential to help in the development of new strategies to produce resistant plants.", "output": [ "purpose" ] }, { "id": "task1163-d41a5ea557344132b6842a3520ef4ac4", "input": "GC box and DNA stability are shown.", "output": [ "finding" ] }, { "id": "task1163-fab179c2a5684f99bebb46a7e8c7fc0d", "input": "involving 138 and 207 samples respectively.", "output": [ "method" ] }, { "id": "task1163-0040cc1dbde1405b98225ed01bdb4608", "input": "In this review we will explore the critical roles that DCs play in the brain 's response to neuroinflammatory disease with emphasis on how the brain 's microenvironment impacts these actions.", "output": [ "purpose" ] }, { "id": "task1163-82a7e25b433c4d12adb139a352ea2fe0", "input": "Moreover , the biological functions of the expressed nsp15s were assessed in MHV-infected cells.", "output": [ "finding" ] }, { "id": "task1163-bdcc505e24fa4434b7e999e800cc1117", "input": "World Health Organization declared Coronavirus disease-2019 ( COVID-2019 ) a Public Health Emergency of International Concern.", "output": [ "background" ] }, { "id": "task1163-893df1b2983d463594c7a15db9b960f4", "input": "interleukin-1b , tumour necrosis factor-a and nitric oxide.", "output": [ "finding" ] }, { "id": "task1163-084aba900ab74a5e83f5bbdcb35f2758", "input": "The accepted phototoxic mechanism for these types of photosensitizers involves the formation of an excited triplet state upon light absorption that can participate in electron ( Type 1 ) or energy ( Type 2 ) transfer processes.", "output": [ "finding" ] }, { "id": "task1163-6699500640be46a888d4908b2a581e63", "input": "Amyloid fibril formation has long been studied because of the variety of proteins that are capable of adopting this structure despite sharing little sequence homology.", "output": [ "background" ] }, { "id": "task1163-ef6c2b334f94425aa2128a199450e3b6", "input": "its discussion section did not cover recovery that includes resilience.", "output": [ "finding" ] }, { "id": "task1163-8911642927eb456eaa21ba847537f1bf", "input": "Ectopic expression of sIFITM3 significantly inhibited non-enveloped foot-and-mouth disease virus ( FMDV ) infection in BHK-21 cells.", "output": [ "finding" ] }, { "id": "task1163-92ab3cb9f5a44aff99c9441897f2bd21", "input": "Public Health Ontario Laboratories ( PHOL ) launched an investigation of patients being tested for enterovirus D-68 ( EV-D68 ) in Ontario , Canada.", "output": [ "background" ] }, { "id": "task1163-f221ed7dc00342ae9cc6b3bdda86bea7", "input": "microbiologists , ecologists , and policy makers to prevent and control EIDs through the human-animal-environment interface ( 19 ).", "output": [ "background" ] }, { "id": "task1163-7a79b1ebec30445198e834c69fc13bc4", "input": "each diverging at a conserved proline residue located in the middle of an α-helix.", "output": [ "finding" ] }, { "id": "task1163-b5f8e7d6f2d24f329be7cdbf238720c9", "input": "The aim of this study was to report two cases of Clostridium perfringens type A and Clostridium difficile coinfection in adult dogs.", "output": [ "purpose" ] }, { "id": "task1163-6993786f44964b4f85912864676981a9", "input": "favoring disease establishment by applying in one action using the same viral protein to coordinate viral replication and breaking down plant defense.", "output": [ "purpose" ] }, { "id": "task1163-90677f24b4e8404c9e1dd27f585b7d67", "input": "airport screening is frequently implemented to limit the probability of infected cases entering other regions or countries.", "output": [ "finding" ] }, { "id": "task1163-bd29ffc1c37d44938029985f3c81bfc3", "input": "Presence of acidosis and multiorgan failure was found to be predictor for mortality.", "output": [ "finding" ] }, { "id": "task1163-4bcdaa9c97b94d65b3418c881243a20c", "input": "and up to 24 h following subcutaneous PHA injection.", "output": [ "finding" ] }, { "id": "task1163-62d770a7c409406aab5c74581291298b", "input": "A real-time PCR assay was developed for the detection of CRCoV.", "output": [ "purpose" ] }, { "id": "task1163-ad0b7ee440cc4e1cb16a6e1d28e2adcb", "input": "Interestingly , Domain II ( aa151-250 ) had an inhibitory effect on Domain IIIbut not on Domain I-mediated speckle formation.", "output": [ "finding" ] }, { "id": "task1163-67b6ae5fb2584a289205d83e9d144454", "input": "which places it among the most bat-rich countries in the world.", "output": [ "method" ] }, { "id": "task1163-9e8bcd5b9b334c8897004d3a82a763a7", "input": "In this study , we selected this cell population as a target to investigate the extreme inflammatory response during severe influenza infection.", "output": [ "purpose" ] }, { "id": "task1163-3c2c64e9ef51480d83e652fc103ef33e", "input": "All the MWPyV-positive specimens were also screened for other common respiratory viruses.", "output": [ "method" ] }, { "id": "task1163-3ee63478915d4f3f945eff9ae970a97c", "input": "FMDV antigens were rarely detectable within few epithelial cells in regions of mucosa-associated lymphoid tissue ( MALT ).", "output": [ "finding" ] }, { "id": "task1163-5e7c50d911ce425b900ce27a8b15756f", "input": "during rotavirus infection in MA104 cells with regard to viral growth and particle assembly.", "output": [ "purpose" ] }, { "id": "task1163-8453fdf7307c43bc82d6e9d383cd28c5", "input": "Respondents were from 13 years and above.", "output": [ "method" ] }, { "id": "task1163-dc4e31b9357d448aa0baef71ef9e4675", "input": "In the present study , we empirically tested the success rate of the MPR in obtaining the outgroup root for a given phylogenetic tree.", "output": [ "purpose" ] }, { "id": "task1163-895ccac32302487b9a28dec01dd8cd56", "input": "Mathematical models can be very useful for understanding the effects of various factors on the spread and control of infectious diseases.", "output": [ "finding" ] }, { "id": "task1163-9814435289ac40fea235dc0bd8764ed8", "input": "and peripheral infection , causing cumulative damage and eventually development of AD.", "output": [ "background" ] }, { "id": "task1163-b7e4ec3c9f3a4410ab4eb4b318af90ad", "input": "This discussion provides descriptions of these expressions through nurses who experienced the crisis and chose to go on the public record.", "output": [ "purpose" ] }, { "id": "task1163-38a30b700fb544d187a7f1f7366accd4", "input": "This model can be modified to reflect updated transmission characteristics and more specific definitions of outbreak control to assess the potential success of local response efforts.", "output": [ "finding" ] }, { "id": "task1163-bf353fbaaf644a72becd4a4b25cbfc8c", "input": "Epithelia exposed to 95 % oxygen plus 1 ppm ozone were stratified and nonciliated or very sparsely ciliated.", "output": [ "finding" ] }, { "id": "task1163-cec4f11da1c24dfcba975f013e858d72", "input": "identifying four possible reasons for the slow development of an effective protocol and describing eight future directions to improve the current protocols.", "output": [ "purpose" ] }, { "id": "task1163-68ca5c95b7744bb0b15f246062e57e6a", "input": "including the catalytic Cys25 and His162.", "output": [ "finding" ] }, { "id": "task1163-931a8e4592df4cedb8b9f9245d75db78", "input": "the HR1 fragment binds to HR2 to form a six-helix bundle with three HR1 fragments forming the central coiled bundle surrounded by three coiled HR2 fragments in the post fusion conformational state ( fusion core ).", "output": [ "background" ] }, { "id": "task1163-f4c8abf59f8d495e945ec0be30c0db1e", "input": "using Great Britain and the United States as examples.", "output": [ "method" ] }, { "id": "task1163-d020e8995987418293a1866f2f0ff9d1", "input": "similar to brown bat endogenous retrovirus ( FERVmlu1 , FERVmlu2 ) were found within a 140 Kbp interval in the middle of class I region.", "output": [ "finding" ] }, { "id": "task1163-bd43bb78315e459a99c75b77cddc4d43", "input": "On average , these pathogens share little sequence similarity and use different replication and transcription strategies.", "output": [ "background" ] }, { "id": "task1163-ce534dd2ee104179bc146aa1f9ffa98a", "input": "The present study focuses on the neuroprotective effect of glycyrrhizic acid ( GA , a major compound separated from Glycyrrhiza Radix , which is a crude Chinese traditional drug ) against glutamate-induced cytotoxicity in differentiated PC12 ( DPC12 ) cells.", "output": [ "purpose" ] }, { "id": "task1163-fbc629fb680f4e0a8fefa66d0a5de40a", "input": "A field experimental study was designed with the QAC plus daily hypochlorite cleaning as the experimental group and hypochlorite cleaning alone as the control group.", "output": [ "method" ] }, { "id": "task1163-0e686533d64e436d86d3f04d503f630b", "input": "leading to central sympathetic activation that results in systemic vasoconstriction.", "output": [ "finding" ] }, { "id": "task1163-93ad2c2e3afa4fb8821ff2df60adb303", "input": "I outline a framework that uses specific molecular characteristics to rank virus families by their expected a priori ability to complete each of three steps in the emergence process ( encounter , infection , and propagation ).", "output": [ "method" ] }, { "id": "task1163-59652b13338a4cf083808c08885e95e7", "input": "it ultimately provides molecular epidemiological data from polioviruses used to inform programmatic and immunization activities.", "output": [ "purpose" ] }, { "id": "task1163-39cb88e088294f4287b91dbc12af2ca5", "input": "house detergent , and a peroxygen compound ( Virkon S ; Antec International ) on the virus were also studied.", "output": [ "method" ] }, { "id": "task1163-d45e42a54e804cbdaa0571c775ae3e79", "input": "Experimental assays show that titanium containing polyoxotungstates have anti-influenza-virus activity.", "output": [ "background" ] }, { "id": "task1163-55a06adf43aa4e329021211c463ae708", "input": "Biases are therefore imbedded in surveillance systems ; these biases need to be characterized to provide better situational awareness for decision-making purposes.", "output": [ "background" ] }, { "id": "task1163-1f7f7379e28541d08b316cf66cab3098", "input": "Objectives-Identify candidate pathogens in pediatric patients with unexplained respiratory disease.", "output": [ "purpose" ] }, { "id": "task1163-35af827a449f4ca2943a866f96608227", "input": "The profile of the fecal bacterial microbiota was compared using 16S amplicon sequencing.", "output": [ "method" ] }, { "id": "task1163-4bb95163809649a181f60071793304c5", "input": "2013 , and June 3 , 2013.", "output": [ "method" ] }, { "id": "task1163-19e16e39c0904c33b2b75b17abe133ea", "input": "and response measures for the primary eye care provider.", "output": [ "purpose" ] }, { "id": "task1163-375574a57725469fa547104e3db9a9f9", "input": "and conjugated with rAzu to develop a general platform for electrochemical detection of miRNAs and viral DNAs with high reproducibility and ultra-sensitivity towards single base pair mutation.", "output": [ "method" ] }, { "id": "task1163-be46dd23ab634de1aa0818ee49786965", "input": "we generated recombinant MP-12 encoding Punta Toro virus Adames strain NSs ( rMP12-PTNSs ) or Sandfly fever Sicilian virus NSs ( rMP12-SFSNSs ) in place of MP-12 NSs.", "output": [ "method" ] }, { "id": "task1163-d96425bc30694dc4b094f0b3da5e0786", "input": "Transcription of hepatitis B virus ( HBV ) from the covalently closed circular DNA ( cccDNA ) template is essential for its replication.", "output": [ "background" ] }, { "id": "task1163-52decc99a2c242a9962b0c59b7eb2047", "input": "The biologic function of this cell surface-expressed viral protein remains unknown.", "output": [ "finding" ] }, { "id": "task1163-388c2f8da9a8436fba3ab7485752a011", "input": "Chronic cough patients also underwent cough reflex sensitivity testing using citric acid.", "output": [ "method" ] }, { "id": "task1163-a7bb0841531d4dbb946ee372b3dec9e2", "input": "In this study , the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization ( SSH ).", "output": [ "background" ] }, { "id": "task1163-cee9c99692e647c983a9e384ffeb2a9b", "input": "ribavirin , and intravenous immunoglobulin were higher in the SARS group.", "output": [ "finding" ] }, { "id": "task1163-860508979b334f128b435eb9c6272a6b", "input": "Thus , several locations may represent the same indoor environment at a different time.", "output": [ "method" ] }, { "id": "task1163-45448003b4e94cef84e10834b40b900e", "input": "we include examples from our own work that are intended to provide insights into the process that led to the selection of particular strategies.", "output": [ "method" ] }, { "id": "task1163-e50cb06f0c9e44c091224cad372f676a", "input": "More recently , a different cell model and the focus on the water soluble fraction of the extract led to the discovery of other compounds.", "output": [ "background" ] }, { "id": "task1163-06c57bc92768462986f70a982568d854", "input": "Nasal samples were obtained during 4 asymptomatic surveillance visits and during symptomatic URIs.", "output": [ "method" ] }, { "id": "task1163-f75f73e124584ab4bb82b3e053bed320", "input": "numerous model predictions on the COVID-19 epidemics in Wuhan and other parts of China have been reported.", "output": [ "background" ] }, { "id": "task1163-377e9afee120448480278e653266d24a", "input": "publicly funded repositories , such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.", "output": [ "background" ] }, { "id": "task1163-4df096cfcd894edfba72d4f17516ed2a", "input": "1 This article presents an overview of the PHS and how Commissioned Corps officers respond during times of national and global need.", "output": [ "purpose" ] }, { "id": "task1163-cb8ee17f95b64f03bf223d5d98a81ddb", "input": "perhaps through activation of NF-κB.", "output": [ "background" ] }, { "id": "task1163-40a36b71916e4d1682229e2da95b42a9", "input": "Particularly , the models can help identify potential adverse effects of vaccination and drug treatment in the case of pandemic influenza.", "output": [ "finding" ] }, { "id": "task1163-5b93d750452d4c828670ad395e693c68", "input": "the nucleocapsid protein of SARS-CoV-2 ( nCoVN ) functions in packaging the viral genome and viral self-assembly.", "output": [ "background" ] }, { "id": "task1163-5adb8235cd924242ac294884a1484a36", "input": "We undertook a sentinel event strategy ( where single health events signal emerging trends ) to estimate the incidence of COVID-19 in the US.", "output": [ "purpose" ] }, { "id": "task1163-a9c9f42e5e3b48c3bd45cdcf1e18d78a", "input": "PAM-pCD163 , and tested for its potential to inhibit IFN-b induction.", "output": [ "method" ] }, { "id": "task1163-d857968cff1a4138b950731513307f9d", "input": "is dependent upon a stem-loop structure beginning 14 nt downstream of the slippery site.", "output": [ "finding" ] }, { "id": "task1163-7e602f1c1da14ab8a687e005b5cb12f4", "input": "plasma IgG , and lymphocyte counts were not affected by treatment.", "output": [ "method" ] }, { "id": "task1163-165e29c280d542188e0d2c50729bfc0e", "input": "The evolutionary history was computed by using Tamura-Nei model with 1 000 replicates of bootstrap analysis.", "output": [ "method" ] }, { "id": "task1163-3caf2fe3bef149f0b9d6a8a056834c4d", "input": "Here , we take a step toward this vision by developing an approach that couples isothermal amplification of specific plant pathogen genomic sequences with customizable synthetic RNA regulators that are designed to trigger the production of a colorimetric output in cell-free gene expression reactions.", "output": [ "purpose" ] }, { "id": "task1163-59e78931f7534104a636ca18d7aeb3af", "input": "View obstruction level and the applicable premium are useful information for stakeholders of the property market for making optimum decisions.", "output": [ "background" ] }, { "id": "task1163-75561da428e94a398129d483abb576bc", "input": "A novel air dehumidification system is proposed.", "output": [ "purpose" ] }, { "id": "task1163-bf56ee34adb54263bee499137102d6b4", "input": "we performed viral metagenomics to assess other potential viral pathogens.", "output": [ "method" ] }, { "id": "task1163-5408116d1be14b6ea030edb10d95ea65", "input": "Background : The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease.", "output": [ "background" ] }, { "id": "task1163-1ecce3ac88ce44dcb977b01ca194bb5c", "input": "Objective : We tested the hypothesis that medical students receive insufficient training on correct methods for donning and doffing PPE.", "output": [ "purpose" ] }, { "id": "task1163-4fd507a3b6ff456a830a9f15b0b81364", "input": "The effects of oral immunization of CpG DNA together with inactivated TGEV ( ITGEV ) were investigated in this study.", "output": [ "purpose" ] }, { "id": "task1163-5d7a0927f6984e32bc20b2c20e6222cb", "input": "We evaluated the proposed method over a number of spatial and spatio-temporal datasets ( Breast cancer mortality in Northeastern US 1988-1992 and different types of cancer in New Mexico 1982 -2007.", "output": [ "method" ] }, { "id": "task1163-c27d980763904ed39d5e4da31c8d62ec", "input": "and the relationship between those depressive symptom levels and the types of outbreak event exposures experienced.", "output": [ "purpose" ] }, { "id": "task1163-21417a0aa7994a54855ab8278a772be0", "input": "F and G were identified.", "output": [ "finding" ] }, { "id": "task1163-a4beb44f974f4eb68f49ff80cc50014f", "input": "with onset of illness in the same 10-day period.", "output": [ "background" ] }, { "id": "task1163-262e1e8a51d14e839f17f1c6f21b2aa1", "input": "The overall clinical score corresponded well with the shedding of viral RNA the first three weeks after challenge.", "output": [ "finding" ] }, { "id": "task1163-043de4a890f140d6a9d1d5ca3ea8d7de", "input": "This review discusses emerging evidence for the diversity of this fascinating group of membrane serine proteases as potent modifiers of the pericellular microenvironment through proteolytic processing of diverse substrates.", "output": [ "purpose" ] }, { "id": "task1163-73866ebdbb0449e5903335cc6918207b", "input": "It is of crucial importance to estimate the reproductive number ( R0 ) of the novel virus in the early stage of outbreak and make a prediction of daily new cases on the ship.", "output": [ "background" ] }, { "id": "task1163-2849d4d01603426fbaebf78d157379e6", "input": "The aim of the present work was to study if maternal IgG1 antibodies ( Abs ) to BCoV acquired by colostrum intake modulate the development of BCoV infection in calves reared in a dairy farm in Argentina.", "output": [ "purpose" ] }, { "id": "task1163-18528f51c8b54b06bbe8d7ac0ad3493f", "input": "so unbiased metagenomic sequencing was performed.", "output": [ "method" ] }, { "id": "task1163-b08bf0bccd0b4dc6a0b847afb0236131", "input": "in turn , carry out effector functions that serve to protect or destroy.", "output": [ "background" ] }, { "id": "task1163-38e34b9eea594d1a80158ad7c95c47a6", "input": "Flanking sequences were standardized by head-to-tail insertion of several copies of an RNA7 body TRS cassette.", "output": [ "method" ] }, { "id": "task1163-59d6f820c37149b88dce07a769aa52f7", "input": "which has been linked to a wide range of human health and disease states , including viral infection.", "output": [ "background" ] }, { "id": "task1163-66df87e5c6d946d8a5a446700273b0c1", "input": "leading to an increase of positive charge on C ( CO ) of Gln and negative charge on N ( NH ) of Ser.", "output": [ "background" ] }, { "id": "task1163-80b935bd15774da7936e7b6c918ce380", "input": "We conducted a nationwide inpatient cohort study based on the Taiwan National Health Insurance Research Database between 1997 and 2011.", "output": [ "method" ] }, { "id": "task1163-5944804485b54f6c8dbf85bfb64165df", "input": "and we compare viruses identified at the time of diagnosis of sinusitis with those identified early in the URI.", "output": [ "purpose" ] }, { "id": "task1163-967cd5a53f8742acb1faea80c7fb047d", "input": "In this review , we will discuss recent advances in our understanding of yeast and mammalian TRAPP at the structural and functional levels and its role in disease while trying to resolve some apparent discrepancies and highlighting areas for future study.", "output": [ "purpose" ] }, { "id": "task1163-bc3ca1e0248342a3a4acbd23da242454", "input": "Aa-tRNAs were precipitated with ethanol and dissolved in water ; concentrations were determined photometrically by absorbance at 260 nm.", "output": [ "method" ] }, { "id": "task1163-0d6521c61c1a408f91a8fc58f61aa3ab", "input": "gallotannins were identified in the banaba extract as components responsible for the activity , not corosolic acid.", "output": [ "background" ] }, { "id": "task1163-d4c51396be39419982cc77cde861b821", "input": "although at a lower level compared to M , N and E co-expression.", "output": [ "background" ] }, { "id": "task1163-f5068efcbbdf4acca3f24cde4d7416b0", "input": "Mice were orally treated for 9 consecutive days starting on the day of infection with daily ATA doses of 50 and 100 mmol/kg.", "output": [ "method" ] }, { "id": "task1163-f96ad1d7bfb74327a86a6e107cd6cc0d", "input": "9th edition code and identification of only patients with more severe ARDS in this analysis.", "output": [ "finding" ] }, { "id": "task1163-df9f2f9dba0a49699d42d21df67447b0", "input": "further revealed that translational selection played the dominant role over mutation pressure in the codon usage bias.", "output": [ "finding" ] }, { "id": "task1163-94c0f0d070264486b0d52bd39ebc7db9", "input": "transmission of MERS-CoV is geographically limited ( 12 ).", "output": [ "background" ] }, { "id": "task1163-3f91708b68484a25a6d9ef82cee3b10c", "input": "The data were analysed on the basis of the constructivist version of grounded theory.", "output": [ "method" ] }, { "id": "task1163-b38fefde68984c4a9c968d1ff256273e", "input": "and low likelihood of sustainability beyond the end of the program ' s implementation.", "output": [ "background" ] }, { "id": "task1163-5b7d4c44cee84c69bfa44fe6520c41a8", "input": "Case report We report a case of acute respiratory distress syndrome ( ARDS ) complicating severe EBV pneumonia and requiring prolonged artificial ventilation.", "output": [ "purpose" ] }, { "id": "task1163-177a9f29765547a7b8b582b62fc8c463", "input": "marital status and education level.", "output": [ "purpose" ] }, { "id": "task1163-6be7ba6e6265414991d96739d2ece362", "input": "We propose a feasibility study to demonstrate our ability to recruit and retain patients and conduct a placebocontrolled trial of Pelargonium sidoides extract EPs ® 7630 in lower respiratory tract infection where pneumonia is not suspected.", "output": [ "purpose" ] }, { "id": "task1163-b81bbedf8fe449d9bde72cf01b3a5202", "input": "We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients.", "output": [ "purpose" ] }, { "id": "task1163-d95c61a6b054461fbcb9a54ca97ab654", "input": "The compound 19 was the best and showed comparable MICs to the known compound karanjin.", "output": [ "finding" ] }, { "id": "task1163-9297146652ed4efcb3f21818ffadfaa1", "input": "splicing , turnover , and protein synthesis.", "output": [ "background" ] }, { "id": "task1163-13f2a5957c2340a8bfd08963c489d065", "input": "and made it possible to investigate SCUB patterns in cotton nuclear and organelle genomes.", "output": [ "background" ] }, { "id": "task1163-3ee52b147086480aad215c06d0bd7db0", "input": "viperin , was overexpressed in A549 cells resulting in a significant reduction in viral replication.", "output": [ "finding" ] }, { "id": "task1163-d10330da5f6d43878b0e291643401e05", "input": "We have studied the inhibitory properties of aurintricarboxylic acid ( ATA ) against YopH phosphatase and found that at nanomolar concentrations ATA reversibly decreases the activity of YopH.", "output": [ "finding" ] }, { "id": "task1163-79fe221061814ecfbe4636fc9f976454", "input": "Here , this attachment molecule was identified as heparan sulfate for both Nipah virus and Hendra virus.", "output": [ "finding" ] }, { "id": "task1163-b5ebc4ea924c4586af5cbad91b75b2c7", "input": "At the same time , the results of a recent dromedary camel embryo transfer study which produced a high morphologic integrity and survival rate of Open Pulled Straw-vitrified embryos are also discussed.", "output": [ "purpose" ] }, { "id": "task1163-dd1b2ce4b968493dbb67cbfeee7b5709", "input": "Monoclonal antibody isolation was perfomed as previously described ( Pappas et al. , 2014 ; Traggiai et al. , 2004 ).", "output": [ "method" ] }, { "id": "task1163-d86c58ad450f4b29b58a14868bfd8aa0", "input": "are critical for host survival.", "output": [ "background" ] }, { "id": "task1163-7a8c37212d834c7bacd2480dad0167dc", "input": "The SARS-coronavirus ( SARS-CoV ) is the etiological agent of the severe acute respiratory syndrome ( SARS ).", "output": [ "background" ] }, { "id": "task1163-739c351333924483a85eed5ddfb992ba", "input": "undue avoidance of governmental structures / preference to non-governmental organizations and exclusion of local expertise.", "output": [ "background" ] }, { "id": "task1163-e75024f1db754deb9c97cb66236fe6c8", "input": "they have been associated with illnesses that require hospitalization.", "output": [ "background" ] }, { "id": "task1163-d850870ca58447fbaa6ec3767664040c", "input": "has been implicated as a major factor in Alzheimer 's disease ( AD ).", "output": [ "background" ] }, { "id": "task1163-52e93b58d76e442f8a9e9fafe1503245", "input": "Demographic data were used to link SARI patients to Arizona death certificates.", "output": [ "method" ] }, { "id": "task1163-1f890a634a4f4676941c5d8da2ebd639", "input": "The histopathological picture as well as the laboratory findings suggests a viral cause of the disease.", "output": [ "finding" ] }, { "id": "task1163-bddd5ffb259b434e926b2e4b9d34358f", "input": "continuously spurred by our never-ending combat against pathogens.", "output": [ "background" ] }, { "id": "task1163-55dbea89a06d42f284be9ecf4927bf0e", "input": "and from each , six to eight sampling sites were visited.", "output": [ "method" ] }, { "id": "task1163-2b8a6e483a474c1fb1632dc09d9ce53e", "input": "The biomarkers were also examined in children admitted with acute bronchiolitis serving as positive controls ( N = 30 ) and in age-matched controls ( N = 20 ).", "output": [ "method" ] }, { "id": "task1163-69f45586d98545ebb8a33d126ac0f1db", "input": "We demonstrated that changes in reporting rate substantially affect estimates of R 0.", "output": [ "finding" ] }, { "id": "task1163-9dee84378c804ab080d3851f0d287429", "input": "VP3 N63Y , that was sufficient for large-plaque formation.", "output": [ "finding" ] }, { "id": "task1163-4f4be85d33e84dc49501d59d691d35d5", "input": "particularly if safety precautions are not rigorously practiced.", "output": [ "background" ] }, { "id": "task1163-719fa1747ab2475dbf1f4ba1a95a406e", "input": "modulation of immunity , and production of bioactive compounds.", "output": [ "background" ] }, { "id": "task1163-54c6299cb1714f62b613cffa0c8ca976", "input": "The cyclic voltammetry experiments suggest that ATA reacts remarkably strongly with molecular oxygen.", "output": [ "finding" ] }, { "id": "task1163-fec17e16330444748032ce47c0b71a71", "input": "The main objective was to report real-time effective reproduction numbers ( R ( t ) ) case fatality rate ( CFR ).", "output": [ "purpose" ] }, { "id": "task1163-353b8127ffed4c9f8819f2e27acfd8ba", "input": "and psoriasis , we investigated inflammatory skin disease in transgenic mice that constitutively overexpress human TGF-β1 in basal keratinocytes ( K5.hTGF-β1 transgenic mice ) ; these mice had previously been reported as having a psoriasis-like disease.", "output": [ "purpose" ] }, { "id": "task1163-76f8bb4bff9044b88f47e58aa2c3dc5c", "input": "Western analysis , use of glycosylation inhibitors and mutagenesis to remove receptor glycosylation sites identified a possible role for cell-specific glycosylation in the modulation of virus entry.", "output": [ "finding" ] }, { "id": "task1163-02a3b2a6a62a4f158b5be09150d4f471", "input": "HEK 293 cells were transiently transfected with full-length wild type HA expressing plasmids.", "output": [ "method" ] }, { "id": "task1163-e343f0ba32aa4c9db5cc99576c1fe250", "input": "In conclusion , these attenuated vaccines have potential for controlling local Taiwanese IBV infections in chickens.", "output": [ "finding" ] }, { "id": "task1163-9d26ef1d74b3488690fe363f0d256c96", "input": "The patient had eaten no recent restaurant foods and had no known sick contacts.", "output": [ "background" ] }, { "id": "task1163-b074edd1ae4e42a4bc08a2ef88724801", "input": "The aim of this study was to introduce Alphitobius diaperinus as a new intermediate host for Hadjelia truncata.", "output": [ "purpose" ] }, { "id": "task1163-688e8b8880ff4c2b8d1e0f24e7e90d91", "input": "different cells , and various proteins that protect the host from pathogens.", "output": [ "background" ] }, { "id": "task1163-c05559b97ce14d6d8b46b259ac27574f", "input": "based on disease progression and response to treatments.", "output": [ "method" ] }, { "id": "task1163-81c3192d24a043f69cc9509643f697ca", "input": "In contrast , NO synthase ( NOS ) inhibitors reverse such lung injury.", "output": [ "finding" ] }, { "id": "task1163-0d0b9cfa5cbc4796816d51664781ee4e", "input": "activation and function of different lymphocyte subsets.", "output": [ "purpose" ] }, { "id": "task1163-f69105396e914f83a61827fa7c92112f", "input": "In this article , we describe application of an infectious clone system for DENV serotype 1 ( DENV1 ).", "output": [ "purpose" ] }, { "id": "task1163-0cd63fc1c4f845329e77879cfdf63fc3", "input": "corosolic acid was isolated from the methanol extract of banaba and shown to be an active compound.", "output": [ "background" ] }, { "id": "task1163-c52c6e88841e4918b7bc9a2cb5198f1d", "input": "but the regulatory functions of CTSL on mucosal immune responses have n't been tested and remain undefined.", "output": [ "background" ] }, { "id": "task1163-7dc59a0bf5fb4310b967d10409fa0809", "input": "This protocol represents an important advancement that will enable more efficient research into the interaction between brazzein and the receptor as well as investigations to test the potential of brazzein as a commercially viable natural low calorie sweetener.", "output": [ "finding" ] }, { "id": "task1163-af3a9c31d8b1476f9c711c4eefa5f17c", "input": "processes and outputs and applies them into the 2003 SARS and MERS outbreak in South Korea.", "output": [ "method" ] }, { "id": "task1163-7e19b803e4754377828433d56200bad9", "input": "G. abietina , though they might have had an innocuous ancestral relationship.", "output": [ "finding" ] }, { "id": "task1163-9641395ebefc4cc5bc1566a036c4af46", "input": "we find that within-host spread is associated with viral replicative speed and not standing genetic diversity.", "output": [ "finding" ] }, { "id": "task1163-f725cd8dc77149b08ebc86208d480e96", "input": "We studied the spatial distributions of simulated virus-laden respiratory droplets when human subjects wore facemasks and were exposed to regulatory viral droplets by conducting in vivo experiments in facemask use.", "output": [ "purpose" ] }, { "id": "task1163-667c0d6b86ee4751ac7111bd57da56a1", "input": "The virus probes are used not only to identify known viruses but also for discerning the genera of emerging or uncharacterized ones.", "output": [ "method" ] }, { "id": "task1163-50fd2cedac3e4417a2805b4846471898", "input": "The study comprised 67 patients with skin or mucous membrane lesions suggestive of herpes simplex virus ( HSV ) infection.", "output": [ "method" ] }, { "id": "task1163-7b94b61c59d8421997dbc160e218bdd0", "input": "This study used the Technology Acceptance Model ( TAM ) to examine taxpayers ' acceptance of the Internet tax-filing system.", "output": [ "purpose" ] }, { "id": "task1163-0aceb966e98e44ef84d89a49acdb9dc7", "input": "is used for the assessment of the influence of LCCs on the South Korean and airline industry.", "output": [ "method" ] }, { "id": "task1163-199105ea421d482a83a9fabcc8923cdd", "input": "also exhibits considerable oncolytic activity against mammalian cancers.", "output": [ "background" ] }, { "id": "task1163-5e309a722a3f493ab2c5099a0fa1871e", "input": "The synonymous codons are not used at equal frequencies in coding sequences in many organisms ( 1 ).", "output": [ "background" ] }, { "id": "task1163-b743eabd518a4df6ac7cda6a850e3236", "input": "This work explores how protein states can be manipulated through controllability analysis : the determination of the minimum manipulation needed to drive the cell system to any desired state.", "output": [ "purpose" ] }, { "id": "task1163-70d6828d10f64110bf5ca424eba26cb2", "input": "This study explores the impact of domestic low-cost carriers ( LCCs ) on regional tourism and aviation industries.", "output": [ "purpose" ] }, { "id": "task1163-b5c247d3a1ce48ef9ea80ab1e5e4cbf4", "input": "Relevant research is reviewed , and policy options are discussed.", "output": [ "finding" ] }, { "id": "task1163-f7e57452c39349bebed1b6dee21482e1", "input": "Seventy-five peptide sequences were modelled and their MHC class I molecule-binding abilities were analysed by molecular docking.", "output": [ "method" ] }, { "id": "task1163-869be3a0ed29405caf05ca48aa4ce2bc", "input": "thereby providing more possible cooperation in the case of disasters.", "output": [ "finding" ] }, { "id": "task1163-ce4aef5316f64dfa8cfa7ea059535fa9", "input": "The spinal cord and its leptomeninges were involved to a lesser degree.", "output": [ "finding" ] }, { "id": "task1163-a937c998a8b34e2bbb62c5cb834e5397", "input": "The amplicon is labeled during on-chip RPA by reverse oligonucleotide primers coupled to a fluorophore.", "output": [ "method" ] }, { "id": "task1163-2e8a0888aafb4f87898785719429e64d", "input": "Its incidence is estimated at 75 cases per 100,000 population and appears to be increasing ( 1 ).", "output": [ "background" ] }, { "id": "task1163-49aa4229d08145b8810d86503b2470fc", "input": "The severe acute respiratory syndrome ( SARS ) coronavirus ( CoV ) was identified as the etiological agent of an acute respiratory disease causing atypical pneumonia and diarrhea with high mortality.", "output": [ "background" ] }, { "id": "task1163-482b3bc69f99430ea7b863cdc56cf01a", "input": "Realistic surveillance simulations may prove invaluable to optimize system design and tuning.", "output": [ "finding" ] }, { "id": "task1163-5508e8f85ede4aa086246cc899d8000f", "input": "Conclusion : The study demonstrated that spike glycoprotein of the Massachusetts and the QX-like variants of IBV are molecularly distinct and that this may reflect in differences in the behavior of these viruses in vivo.", "output": [ "finding" ] }, { "id": "task1163-e0dc0203eaef400ab41a54616ceaa307", "input": "This chapter summarizes and reviews nonviral DNA delivery for both gene therapy and DNA vaccination in the lung.", "output": [ "purpose" ] }, { "id": "task1163-e5a0fce02a7e4d32b997da2cbf2252fe", "input": "prior to purification , to yield an N-terminally His 6 - tagged protein.", "output": [ "method" ] }, { "id": "task1163-5a578717aec84f3db76338d2c769a89e", "input": "To examine coxsackievirus pathogenesis , we orally inoculated mice with the coxsackievirus B3 ( CVB3 ) Nancy strain.", "output": [ "method" ] }, { "id": "task1163-4a4c87e97ac947f9b644ee52322399e6", "input": "In particular , the identification of non-coding RNAs has revealed their widespread occurrence and functional importance in gene regulation , stress and virulence.", "output": [ "background" ] }, { "id": "task1163-1212d2b312354431ac61d4d0d0ced4a0", "input": "in our experimental settings , MyD88 is redundant for IFN-I responses and overall defense against a systemic herpes virus infection.", "output": [ "finding" ] }, { "id": "task1163-578f8c79a2f2427badcc4700ec3b62b6", "input": "and how these processes orchestrate and govern cell fate upon viral infection.", "output": [ "finding" ] }, { "id": "task1163-6d9fe5a4c7784cfea491a403b6594831", "input": "The objectives of this study were to evaluate the effects of free-access acidified milk replacer feeding on the pre-and postweaning health of dairy and veal calves.", "output": [ "purpose" ] }, { "id": "task1163-fff3ea651ba844938be389345bdb0c35", "input": "The applicability in immunodiagnostics was statistically evaluated by expression of specificity and sensitivity values for individual antigens.", "output": [ "method" ] }, { "id": "task1163-301c5db55ea246b593253f6554427083", "input": "improve food safety and reduce outbreak impacts.", "output": [ "purpose" ] }, { "id": "task1163-39cf2500d42e419dbd2ce4a4fa1ab86a", "input": "alongside genomic data and temporal data.", "output": [ "purpose" ] }, { "id": "task1163-5509f66048254f8386a80b5630cee86b", "input": "Deletion mapping experiments identified two domains responsible for the speckle formation in MHV EGFP-nsp15 : Domain I ( aa101-150 ) and Domain III ( aa301-374 ).", "output": [ "finding" ] }, { "id": "task1163-179a3b96b24e467fb3894e725db25475", "input": "In this study , we report the interaction of a SARS-CoV 7a and small glutamine-rich tetratricopeptide repeat-containing protein ( SGT ).", "output": [ "purpose" ] }, { "id": "task1163-4d6f075cc9e54bd0841d403b478f0a58", "input": "In addition CCSP promoter is commonly used to direct gene expression into the lung in transgenic models.", "output": [ "background" ] }, { "id": "task1163-b273139590eb4b8ba5e9d95ca883f811", "input": "The two best final models were selected : one with and one without NS1 rapid test result.", "output": [ "method" ] }, { "id": "task1163-4d30d5b17d7946e092f621f059fcaf23", "input": "α-synuclein and human amylin , and introduce a small number of peptides that have been shown to be capable of inhibiting the amyloidogenesis of both of these very dissimilar polypeptides.", "output": [ "purpose" ] }, { "id": "task1163-f9dfded40dc44909b3a2885d3f10cec9", "input": "Background : The cause of severe disease in some patients infected with pandemic influenza A virus is unclear.", "output": [ "background" ] }, { "id": "task1163-b73f3fea6f814058aa96979340976a1b", "input": "N63Y , in the VP3 capsid protein that was sufficient to confer the large-plaque phenotype.", "output": [ "finding" ] }, { "id": "task1163-3d2c98e282234cd584a892341074a679", "input": "the onset of severe acute respiratory syndrome coronavirus ( SARS-CoV ) and Middle East respiratory syndrome coronavirus ( MERS-CoV ) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in humans.", "output": [ "background" ] }, { "id": "task1163-ddcf2bac9a484e9393ef74b22d8e59fa", "input": "focusing specifically on infectious diseases by examining cases of outbreaks of infectious diseases that have occurred in Korea.", "output": [ "purpose" ] }, { "id": "task1163-14f5e94c9ed943c4ad129305c0378645", "input": "though eventually it spread to five continents.", "output": [ "background" ] }, { "id": "task1163-6135c41d7cd744cdb4469f1b0d985c7c", "input": "In this study , we report a single nucleotide resolution transcriptome map of H. somni strain 2336 using RNA-Seq method.", "output": [ "purpose" ] }, { "id": "task1163-172bdaeffdc44ab3a58e6c13ecaa4d16", "input": "A Bayesian hierarchical statistical model was developed to examine the statistical relationships between the influenza surveillance data and the information environment represented by alerts from HealthMap and web queries from Google.", "output": [ "method" ] }, { "id": "task1163-978714215ad846c7bfb54a23fd4e3bd9", "input": "Lung suspensions and BAL fluids were titrated for PRRSV.", "output": [ "method" ] }, { "id": "task1163-fa5edfb26d1648b69a8627d8c25ea19f", "input": "to be used throughout the interventional platform.", "output": [ "method" ] }, { "id": "task1163-d11bf7eadca149a4bb9beb413271bd96", "input": "In addition , the efficacy and side effects of NM in cancer patients are summarized in detail.", "output": [ "purpose" ] }, { "id": "task1163-648590297ef3428da4f2b9a7b6d2cfed", "input": "which is rationalized by the arrangement of three domains in space.", "output": [ "finding" ] }, { "id": "task1163-73db033e270b4197bdbdc9127b32ad9f", "input": "characterize CC1 mAb binding , and evaluate CC1 in syngeneic mouse oncology models as a monotherapy and in combination with an anti-PD-1 mAb.", "output": [ "purpose" ] }, { "id": "task1163-31005385181e4a2f88743cc0a6477956", "input": "Methods : Groups of 35 domestic ducks and 10 mallards were exposed to different doses of T. regenti cercariae.", "output": [ "method" ] }, { "id": "task1163-b668756ec4554a868820964345fd3f01", "input": "using a viral gene chip to identify viral DNA or RNA.", "output": [ "purpose" ] }, { "id": "task1163-d6e892bcd71741a29820ca962acf08d4", "input": "We evaluated the effectiveness of exit and entry screening for 2019-nCoV infection.", "output": [ "purpose" ] }, { "id": "task1163-b301b62fc17544d9a3abbcca1bb9d3eb", "input": "or in combination with the removal of six additional genes nonessential for virus replication.", "output": [ "background" ] }, { "id": "task1163-38660874b230461d8e5d162e21671743", "input": "Moreover , other studies outlined factors influencing disaster management and response from a macroscopic perspective and analyzed disaster management and response through awareness surveys ( 8 , ( 12 ) ( 13 ) ( 14 ).", "output": [ "background" ] }, { "id": "task1163-c2505ffdc6864c68910cde150a7357f8", "input": "and lung ultrasonography was performed.", "output": [ "method" ] }, { "id": "task1163-4e90caeb1d1e4f519fc4258ac5712e3c", "input": "and a discrete time delay for the incubation period in disease transmission.", "output": [ "purpose" ] }, { "id": "task1163-a26a173bdddd44f38e03de19107706bb", "input": "Purpose : To assess 2009 H1N1 and seasonal influenza vaccination coverage and identify factors independently associated with vaccination among HCP in the U.S. Methods : Data from the 2009 -2010 Behavioral Risk Factor Surveillance System ( BRFSS ) influenza supplemental survey were analyzed in 2011.", "output": [ "purpose" ] }, { "id": "task1163-4462934c64f84e9ca2030b123945253f", "input": "We conclude with a discussion of the need for public health to expand its horizon and tear down the walls of the silos that inhibit the emergence of relevant global public health.", "output": [ "finding" ] }, { "id": "task1163-76612d2f7be7467380266d79894f65fe", "input": "This enzyme has been shown to be active as a dimer in which only one protomer is active.", "output": [ "background" ] }, { "id": "task1163-16312f9a629d4705beee55c03934328f", "input": "Oligonucleotides were purchased from Invitrogen.", "output": [ "method" ] }, { "id": "task1163-f5df292f062141358967d5fdc526291f", "input": "The results indicated that , compounds 5c and 5i exhibited the most potent antibacterial activity.", "output": [ "finding" ] }, { "id": "task1163-d4e83810c7ab45118c8662ab1aa05873", "input": "Kn2-7 could inhibit all members of a standard reference panel of HIV-1 subtype B pseudotyped virus ( PV ) with CCR5-tropic and CXCR4tropic NL4-3 PV strain.", "output": [ "finding" ] }, { "id": "task1163-d7a8e47e48ce4be9bb6c046f863a40c4", "input": "Here , we present a novel approach for treating SCID that combines selective depletion of GvHD-inducing alpha/beta ( α/β ) T-cells from the haploidentical HSCT graft with a subsequent donor lymphocyte infusion ( DLI ) enriched for CD45RO + memory T-cells.", "output": [ "purpose" ] }, { "id": "task1163-d6270fb112854999ba8ed9c7120116b6", "input": "and NMR data on the conformational states of the N-terminal domain ( SUD-N ) and the SUD-NM two-domain construct.", "output": [ "purpose" ] }, { "id": "task1163-6cc9b665c5d9414eb679cd46027bf674", "input": "using tropism infection and innate immunologic assays.", "output": [ "method" ] }, { "id": "task1163-099d99007f7240d59c1f52a5e5c11447", "input": "We tested the role of the `` spring-loaded '' conformational change in the fusion mechanism of the influenza hemagglutinin ( HA ) by assessing the effects of 10 point mutants in the region of high coiled-coil propensity , HA2 54-81.", "output": [ "method" ] }, { "id": "task1163-5148de167cf94e42a446cdbe60544394", "input": "and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.", "output": [ "method" ] }, { "id": "task1163-1a6ebb33ed214ced8fe8477484b10791", "input": "and critical PCO 2 ≥ 60 mm Hg.", "output": [ "finding" ] }, { "id": "task1163-a6497a4b3a1145398fd9e1082efdc0d0", "input": "using E. coli DNA polymerase III as a conceptual framework ; and 3 ) the promise of genetic and therapeutic interference with fidelity regulation as an approach for attenuation and treatment of CoVs.", "output": [ "purpose" ] }, { "id": "task1163-590d2d7c0f044f71b91170a2f2408d9c", "input": "General agreement exists effective disaster management faces constraints related to knowledge sharing and a need for real-time research responses.", "output": [ "background" ] }, { "id": "task1163-c1d0684c38ac46b1b1ed47e541160b5f", "input": "Only two HCW involved in different clusters , reported pneumonia.", "output": [ "finding" ] }, { "id": "task1163-bb6ee1deeb7d432090368b8acbf6c954", "input": "SNAP and RAPSearch , which are as accurate as existing bioinformatics tools but orders of magnitude faster in performance.", "output": [ "finding" ] }, { "id": "task1163-e4f6cbb27d0840da8dfb2d49792eae9a", "input": "Healthcare settings have played a major role in propagation of Ebola virus ( EBOV ) outbreaks.", "output": [ "background" ] }, { "id": "task1163-6fc6d3cc864d4d3d9e34493e596a036f", "input": "39 Quality Control measures 40 A known amount of whole equine herpesvirus ( EHV ) spiked into each sample assessed nucleic 41 acid extraction quality and presence of polymerase chain reaction ( PCR ) inhibitors.", "output": [ "method" ] }, { "id": "task1163-5143a9ec82474c09ae4341646bd1cd2e", "input": "at any of several intervals relative to ovalbumin ( OVA ) administration resulted in elevated OVA-specific IgG 2 a titers.", "output": [ "background" ] }, { "id": "task1163-5425a8ae5d88405ab3cb42327e4511b3", "input": "In this context , controllability analyses aim to identify key regulating host factors of the infected cell 's progression.", "output": [ "purpose" ] }, { "id": "task1163-a07bc44a904d41608cc02e7dc8b1ed5f", "input": "designated Z2 , potently inhibits infection of ZIKV and other flaviviruses in vitro.", "output": [ "purpose" ] }, { "id": "task1163-61ae66d32a2a45e38212a35e5685d18e", "input": "Polyoxometalate ( POM ) has promising antiviral activities.", "output": [ "background" ] }, { "id": "task1163-e90901b343d14a8c9180221d2f0a0fc3", "input": "HMA has become an important target in the treatment of type-2 diabetes.", "output": [ "background" ] }, { "id": "task1163-8c55faecbaf44f8fafdee50db8f09e12", "input": "The low pH environment of the endosome facilitates passage of the viral genome into the cytoplasm.", "output": [ "background" ] }, { "id": "task1163-e4b269459ecb49fbbb62fad954a74753", "input": "a factor neglected by some previous studies because of their reliance on what A.O.Hirschman ( 1970 ) termed `` paradigmatic thinking ''.", "output": [ "purpose" ] }, { "id": "task1163-51bfe54700684afca5ebeba87ba7ae2d", "input": "animal , and environmental samples.", "output": [ "background" ] }, { "id": "task1163-920fad7ff9cf4469af98585f89d294e7", "input": "Background : The potential risks associated with `` toilet plume '' aerosols produced by flush toilets is a subject of continuing study.", "output": [ "background" ] }, { "id": "task1163-9e72d07cbd9b49b4abb51106d1afd07d", "input": "Existing methods based on free energy minimization tend to be very slow and are limited in the types of pseudoknots that they can predict.", "output": [ "background" ] }, { "id": "task1163-497f9c9b412345ee956fc8d4d6ef8cae", "input": "together with nucleotide binding , imposes a rigid intertwined dimer configuration that is essential for RNase catalytic and antiviral functions.", "output": [ "finding" ] }, { "id": "task1163-4b8a99e5cda5410884a40857390befe4", "input": "Abundant nidovirus-like sequences were identified in cases and were used to assemble the genome of a previously unknown virus in the order Nidovirales.", "output": [ "method" ] }, { "id": "task1163-abb5de1bb3d14b4ea9f60829c3db1a22", "input": "which correlated positively with the age of animals at the time of infection.", "output": [ "finding" ] }, { "id": "task1163-45dc740854154a149061c17276195af5", "input": "We performed a 15-year follow-up on the lung and bone conditions of SARS patients.", "output": [ "method" ] }, { "id": "task1163-4605225067cd45a5b0e7e0b8c324bfa6", "input": "age groups below 6 months were found to be more prone to parvovirus infection and males were mostly infected.", "output": [ "finding" ] }, { "id": "task1163-26797d257b2e48f5a46e16b3de2087cf", "input": "Currently there 32 is no targeted therapeutics and effective treatment options remain very limited.", "output": [ "background" ] }, { "id": "task1163-47c7e636340f47dbaa72f24702632244", "input": "and it was 137.4 and 53.3 times faster than the CFD-Lagrangian model in predicting the steady-state airflow and transient particle transport.", "output": [ "finding" ] }, { "id": "task1163-3349b9e21a34452e90b4c7eba3beb3eb", "input": "Today the plague is still endemic in many countries of the world.", "output": [ "finding" ] }, { "id": "task1163-8face122e24642cf9bc692db93d594ec", "input": "Here we describe Y2H screening strategies that use defined libraries of open reading frames ( ORFs ) and cDNA libraries.", "output": [ "purpose" ] }, { "id": "task1163-c6556b563eaa4c6f95cf38f13413997c", "input": "CLSM-FRET analysis determined the interaction of cav-1α and cav-2 in situ.", "output": [ "method" ] }, { "id": "task1163-7968e9928d754a25831ba42e76aa5f37", "input": "intensive care units continue to see frequent patients with HIV infection.", "output": [ "background" ] }, { "id": "task1163-dbb36d2da8884119a00a7fd8166cf1eb", "input": "Demographics were similar between the 2 groups.", "output": [ "finding" ] }, { "id": "task1163-7a563a9b03cd4b7783738804ac8c4a31", "input": "as a model for severe acute respiratory syndrome ( SARS ).", "output": [ "purpose" ] }, { "id": "task1163-8c6992f220034eb596030879ea8e81df", "input": "The growth advantage observed before weaning in the ACD calves likely disappeared due to the weaning methods used.", "output": [ "finding" ] }, { "id": "task1163-da32daa7a30f425081eaa524dd17fdaa", "input": "It has occurred in three huge pandemics since the 6 th century with millions of deaths and numerous smaller epidemics and sporadic cases.", "output": [ "background" ] }, { "id": "task1163-be80c785ac6547379d268f4c34a904ac", "input": "and HA isolation gown for routine patient care and performing aerosol-generating procedures ( PPE3 ) to prevent EVD transmission by measuring the degree of contamination of HCWs and the environment.", "output": [ "purpose" ] }, { "id": "task1163-251ce4cc4247452b8df5233ee8362af5", "input": "Resveratrol is a naturally occurring phytoalexin in specific plants and exhibits inhibitory activity against many kinds of virus.", "output": [ "background" ] }, { "id": "task1163-45031ad966464222b1661795b639eadf", "input": "we will discuss some recent progress regarding the possible clinically relevant use of the N-protein.", "output": [ "method" ] }, { "id": "task1163-4ccfb1bf601347fc94eb10a11a2f45d1", "input": "The goal of this chapter is to provide a comprehensive overview of olfactory disturbances as it pertains to the sinonasal airway.", "output": [ "purpose" ] }, { "id": "task1163-c6888be0e03b4fd18060438c7a873de0", "input": "secondary structure elements , and the amino acid types.", "output": [ "method" ] }, { "id": "task1163-bf247a923eb4422d9e9c49bea782f7bf", "input": "Study design-This was an observational cohort study in two primary care pediatric practices in Madison , WI.", "output": [ "method" ] }, { "id": "task1163-60725098ab7d4400b2982825e3e634a9", "input": "is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year.", "output": [ "background" ] }, { "id": "task1163-f8a68d1d1a6b43808e6047858a1afb3a", "input": "all four mutants replicated as efficiently as wild-type virus.", "output": [ "finding" ] }, { "id": "task1163-e2141265595744c3a6a4866fb663da6a", "input": "hepatitis B , foot-and-mouth disease , and Norwalk virus.", "output": [ "background" ] }, { "id": "task1163-d28416cefb2f4c089f174752feb5f7b8", "input": "A contact investigation was initiated to identify possible person-to-person transmission and assess infection control measures.", "output": [ "method" ] }, { "id": "task1163-1287c3eaecd248e0ab0dcaf1c8108672", "input": "Virus shedding was monitored using reverse-transcription quantitative polymerase chain reaction ( RT-qPCR ) controlled for faecal inhibitors to ensure sensitivity.", "output": [ "method" ] }, { "id": "task1163-149ee6514c774564a17a31b2d3caec7f", "input": "Esto confirma que los anticuerpos IgG1 calostrales son críticos para la prevención de la infección por este agente viral.", "output": [ "finding" ] }, { "id": "task1163-04cdec26632a4c08b8017259d8a3ab78", "input": "and age-associated prevalence among camels at the largest entry port of camels from Africa into the Arabian Peninsula.", "output": [ "purpose" ] }, { "id": "task1163-74ba30b7cfb3412d99c239135ef869ba", "input": "which emerged in China in early 2013.", "output": [ "purpose" ] }, { "id": "task1163-bc0cfb7595af4231a06fd4b568508196", "input": "To extend these findings , here we tested the efficacy of SCT DNA vaccines against bacterial infections.", "output": [ "method" ] }, { "id": "task1163-7e900ad70da94cebac0deed4585e8f18", "input": "We show that the NTD is a novel RNA-binding domain with poly ( rA ) - preference cooperating with the TOPRIM domain in binding of RNA.", "output": [ "finding" ] }, { "id": "task1163-d6c05eee1490489fb711056513930814", "input": "In this review , we summarize the current views on how aging influences the factors that impact T cell function and how this can affect the immune response to infections , vaccinations , and tumors.", "output": [ "purpose" ] }, { "id": "task1163-3f0b7473a8304784bf839e6470c68c5c", "input": "We therefore intended to present data obtained from a short-term overcrowded neonatal intermediate care unit ( NIMCU ) at a level III ( international categorization ) perinatal center at University Hospital Frankfurt , Germany.", "output": [ "purpose" ] }, { "id": "task1163-4affd3bae4504b368d08e16f90670c58", "input": "has been mapped to mutations in the viral thymidine kinase and the DNA polymerase catalytic subunit , respectively ( 7 ).", "output": [ "background" ] }, { "id": "task1163-e9e585d4dd4744bd9eac3be91fcc2007", "input": "Methods : We conducted a content analysis of all television news items about pH1N1.", "output": [ "method" ] }, { "id": "task1163-607fd7bcab13460c973495499142ee66", "input": "This approach is limited to targeting one amyloidogenic protein at a time.", "output": [ "background" ] }, { "id": "task1163-e28652ad92c84d0784352781c21fc4df", "input": "virus-cell interaction , and viral morphogenesis.", "output": [ "purpose" ] }, { "id": "task1163-fd7e7fc8d1c04a168d9f00c1f14249a4", "input": "These differences were also observed when the total protein levels in both groups were compared ( p = 0.0081 ).", "output": [ "finding" ] }, { "id": "task1163-88663b07a25e4a4cbeb4a6fab1716284", "input": "We comprehensively reviewed the epidemiology of childhood diarrhoea and pneumonia in 2010-11 to inform the planning of integrated control programmes for both illnesses.", "output": [ "purpose" ] }, { "id": "task1163-a91849d06b5c4a71b7ee995e4fa4d35f", "input": "The present study aims to analyze the miRNAs related to pathogenicity of nephropathogenic IBVs.", "output": [ "purpose" ] }, { "id": "task1163-fef1ac9bd2b64218ab394784dae74ce9", "input": "Samples were deemed to be positive if they tested positive for a virus by at least two of the three respective assays.", "output": [ "method" ] }, { "id": "task1163-01a4a4603da744e4bbbf68da6644e9d8", "input": "but test results for respiratory and serum samples were negative for MERS-CoV.", "output": [ "finding" ] }, { "id": "task1163-c78d3882e0ac4b8b88226d7c3f3dc124", "input": "as nanoagents for drug delivery.", "output": [ "background" ] }, { "id": "task1163-cfc7646e127e4a0593e5f5addee1fe2d", "input": "citizen 's groups and military units based on independence and autonomy ( 1 ) ( 2 ) ( 3 ) ( 4 ) ( 5 ) ( 6 ) ( 7 ) ( 8 ) ( 9 ) ( 10 ) ( 11 ).", "output": [ "background" ] }, { "id": "task1163-2cd6983d22da427f97a49e485f192654", "input": "which have been reported to be involved in viral replication.", "output": [ "background" ] }, { "id": "task1163-62b1d3ff2aa1433f980b66a0c72f0103", "input": "we have introduced in our clinical setting the quantitative detection of Epstein-Barr virus ( EBV ) in T-cell-depleted allogeneic stem cell transplant patients.", "output": [ "purpose" ] }, { "id": "task1163-989e17cc2b3c419ea30ca0dddb708786", "input": "as determined via PCR or ELISA , were enrolled.", "output": [ "method" ] }, { "id": "task1163-28e2e504ae9144d4b18ebeafdc4cd3d2", "input": "Coxsackieviruses are enteric viruses that frequently infect humans.", "output": [ "background" ] }, { "id": "task1163-de9107ec53494219aa6008b00916b94c", "input": "and their abundance correlated with viral load ( Ct value ) , confirming HRSV infection.", "output": [ "method" ] }, { "id": "task1163-ccecc1093bcd4c198c33741601541292", "input": "depending on serotypes , thus the Fab could have a smaller antiviral activity than the mAb in vitro.", "output": [ "finding" ] }, { "id": "task1163-2ef87c5f56f3428c8f6d3c1a8cf86c1a", "input": "as a treatment for calf diarrhea.", "output": [ "background" ] }, { "id": "task1163-ffd06e3e915d4b02bd2fe0efe4c1660c", "input": "taking into account the specific route and activities of the travel group.", "output": [ "method" ] }, { "id": "task1163-f48bbee0892c4619b0457f73dec6c740", "input": "and production of clumping factor ( determined with the Staphyslide test ; bioMérieux ).", "output": [ "finding" ] }, { "id": "task1163-99e89a975cd2417cb4ea9bdb69a6a11e", "input": "We established a cold-adapted infectious bronchitis virus ( BP-caKII ) by passaging a field virus through specific pathogen-free embryonated eggs 20 times at 32 • C.", "output": [ "method" ] }, { "id": "task1163-f5b05a1f5ac744b8a2d370a4ee865553", "input": "since failure to clear even one cat can result in re-infection of the others.", "output": [ "finding" ] }, { "id": "task1163-9937e73804634549af3969b71cf67860", "input": "G-quadruplexes are present in eukaryotes , prokaryotes , and viruses.", "output": [ "background" ] }, { "id": "task1163-f4fa3fff65b94ff39ab4b62168b40c68", "input": "and the sensitivities of IgM and IgG rose to 52.2 % and 91.3 % , respectively.", "output": [ "finding" ] }, { "id": "task1163-d736cdd4e8d8425b8dd388c123189bc3", "input": "This is a technique used routinely in our virology laboratory to detect BCoV from stool and nasopharyngeal samples of cattle.", "output": [ "purpose" ] }, { "id": "task1163-16e6d47ecd204e06a3a8daf18d124e74", "input": "both with and without dietary exposure to the PPARA agonist WY-14643.", "output": [ "finding" ] }, { "id": "task1163-bb8993eebfcc40a187afa68483dc3ae7", "input": "while public communication tends to favor more categorical claims.", "output": [ "background" ] }, { "id": "task1163-c415490ff9f34991b969c210faccedb1", "input": "At each level , information is solicited to assess five key risks that are most relevant to each level of operations.", "output": [ "background" ] }, { "id": "task1163-969af7bed8d3410dadfa4f6e61f3bd9f", "input": "thymus and CD34 + stem cells or ( 3 ) primary human skeletal muscle cells.", "output": [ "method" ] }, { "id": "task1163-4f6f3ee4b7544b69b21041d86696b581", "input": "Results : IFN-γ +874 A allele was associated with susceptibility to SARS in a dose-dependent manner ( P < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-e5d86e22e0fc428492f347d926b2023a", "input": "Dengue severity was determined according to the 2009 WHO classification guidelines.", "output": [ "method" ] }, { "id": "task1163-3d41675365384355a0dc1edc292396bb", "input": "A variety of perturbants were employed to characterize the cellular processes involved.", "output": [ "method" ] }, { "id": "task1163-f13deb82eceb41fea65c6e14a17a9a13", "input": "Nonetheless , data interpretation and real understanding of viral dynamics is still hampered by the sheer complexity of the various intertwined spatio-temporal processes.", "output": [ "background" ] }, { "id": "task1163-57b017003b95433e8d1bce5fe5ef6881", "input": "In this connection G-quadruplex recognition and processing by nucleic acid directed proteins and enzymes represents a key event to activate or deactivate physiological or pathological pathways.", "output": [ "background" ] }, { "id": "task1163-76ca40c110cb4dd28f5b5f5d12706ac2", "input": "the raccoon dog should receive more attention in disease prevention and eradication strategies.", "output": [ "finding" ] }, { "id": "task1163-5ae6ec4f818740b6ad3266bc2d3d61c0", "input": "we applied a modified traveling salesman algorithm.", "output": [ "method" ] }, { "id": "task1163-f3903b0e2169473fa58891ca08847973", "input": "This observation suggests that a number of the newly identified sRNAs in strain 2336 may be involved in strain-specific adaptations.", "output": [ "finding" ] }, { "id": "task1163-ef2a277ac21a494ba2b89e504086db0b", "input": "as well as for surveillance of foodborne and waterborne viruses ( 20 ) ( 21 ) ( 22 ) ( 23 ) ( 24 ) ( 25 ) ( 26 ).", "output": [ "background" ] }, { "id": "task1163-fef494eef9ac47059919f61d0e97067b", "input": "A series of experiments in vitro suggested that chronic demyelination is due to a bystander mechanism associated with the virus-induced immune response in which antibody dependent cell-mediated reactions play an important role.", "output": [ "finding" ] }, { "id": "task1163-41cbab87cfe14a2aae74e63c34f6eea2", "input": "volatiles , and antioxidants potential in medicinal plants.", "output": [ "purpose" ] }, { "id": "task1163-edf6bb072bf84c10910cc954a8e754af", "input": "89.6 % could taste the commercial solution and 91.7 % could taste the homemade solution.", "output": [ "finding" ] }, { "id": "task1163-9b96d3fbb0ae45afa70117892ba162da", "input": "axonal damage and neurologic disability.", "output": [ "background" ] }, { "id": "task1163-176e022879224ecf9af84dad3b626155", "input": "This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies.", "output": [ "purpose" ] }, { "id": "task1163-65c653afd4a945a2bafff702ce9e8d7b", "input": "as an additional member of the new family Mesoniviridae in the order Nidovirales.", "output": [ "method" ] }, { "id": "task1163-f3bc3bc24bff4c57a8bf2cc31ee222ea", "input": "Background : Some island nations have explicit components of their influenza pandemic plans for providing travel warnings and restricting incoming travellers.", "output": [ "background" ] }, { "id": "task1163-c582fb05e6d1401baab19d200be03d15", "input": "Pairs grouped into the category of emerging and reemerging diseases were employed to investigate conformity bias ; pairs belonging to the category esthetic uses were considered to be of little adaptive relevance and utilized as an experimental control.", "output": [ "method" ] }, { "id": "task1163-7db93ed8200f45cba3d9eeb5d7cad3d6", "input": "but was found in lymphatic tissue through day 42 after challenge.", "output": [ "finding" ] }, { "id": "task1163-67f99d0dcef6485489cc87280f7fc186", "input": "Gm15441-null mice were developed and shown to be more susceptible to NLRP3 inflammasome activation and to exhibit elevated CASP1 and IL1B cleavage in response to metabolic and inflammatory stimuli.", "output": [ "background" ] }, { "id": "task1163-c058826750ed4c8599689a1039397151", "input": "Methods.", "output": [ "method" ] }, { "id": "task1163-988f8fed0440427691ba32fe1e8811bd", "input": "We recommend that this study be conducted on a larger scale to support our findings.", "output": [ "finding" ] }, { "id": "task1163-555973a9a96c41ef970783ecf4c5fc0b", "input": "Two clusters of patients were defined from chronological data and phylogenetic trees.", "output": [ "finding" ] }, { "id": "task1163-1f44d12692a84d2d9daa650c3862f186", "input": "In contrast , Japan suffered the shortest bubble period and no evidence has documented the existence of crash there.", "output": [ "finding" ] }, { "id": "task1163-03bea07dfaea4bff866b8470c0ae60fc", "input": "Sprague-Dawley rats were injected intraperitoneally with a suspension of Trypanosoma brucei brucei.", "output": [ "background" ] }, { "id": "task1163-9fba97dabe0544268a63dae6fff75241", "input": "e.g. in the development of vaccines for new viruses.", "output": [ "background" ] }, { "id": "task1163-5af5739acc404babb2cf80c57ace1672", "input": "and 70 % outside the household ( see Supplementary Information ).", "output": [ "method" ] }, { "id": "task1163-cd1567fd2255450086b248c445640ea7", "input": "a Chinese herbal formula , in the treatment of patients with wind-cold type common cold.", "output": [ "purpose" ] }, { "id": "task1163-9b3f11e74249486fa938a4db26122735", "input": "The expression of 68Kp '' '' was restricted to mammary tissues of BALB/cV mice that also expressed other MMTV proteins.", "output": [ "finding" ] }, { "id": "task1163-8e8d0c7b6b164411ad45e1193a564127", "input": "The combined data were used to characterize the relationship of the translated proteins of 2019-nCoV to other species of Orthocoronavirinae.", "output": [ "method" ] }, { "id": "task1163-3bcc2ceeb7974380b7da3929149aac00", "input": "but detection of viral RNA does not necessarily indicate a transmission potential.", "output": [ "finding" ] }, { "id": "task1163-875c02670f284469bef031188f2171f1", "input": "The binding constants were estimated by the change of migration time of the analytes in the buffer solution containing different concentrations of SARS 3CL proteinase.", "output": [ "method" ] }, { "id": "task1163-970f0675434e465a9dfbc96ba00dc7d0", "input": "namely framework genes , including three olfactory receptor genes.", "output": [ "finding" ] }, { "id": "task1163-526b3538936b48dcafea58d44c98f164", "input": "DNA samples from 410 febrile children and 60 afebrile children were analyzed by quantitative PCR.", "output": [ "method" ] }, { "id": "task1163-dd56f350bd54439da0fa20b3a6271353", "input": "underwent clinical evaluation , fractional exhaled nitric oxide measurement , and sputum induction.", "output": [ "method" ] }, { "id": "task1163-346e816858a048adae0eb1d776a92d5a", "input": "Clara cell secretory protein ( CCSP ) is specifically expressed in pulmonary Clara cells and is widely used as a Clara cell marker.", "output": [ "background" ] }, { "id": "task1163-9b3c170ba59f40b68947e3414a2ff09b", "input": "Consistent with these data , we showed that Tat transactivation of the Egr-1 promoter was abrogated when astrocytes were cultured in serum-reduced media.", "output": [ "finding" ] }, { "id": "task1163-29f804516be844afb2d215404f99a22e", "input": "Therefore , we investigated which cells are stimulated to produce IFN-I following CVB3 infection and which cell types have to be IFNAR-triggered in order to confer antiviral protection.", "output": [ "purpose" ] }, { "id": "task1163-f9b7b4a4d8f44e7684b8731fd561b491", "input": "In this report , ribavirin was shown to inhibit SARS-CoV replication in five different cell types of animal or human origin at therapeutically achievable concentrations.", "output": [ "purpose" ] }, { "id": "task1163-88ac878b3fef4b788a35822675d9eaac", "input": "Background Acute respiratory tract infections ( ARTIs ) are one of the major causes of morbidity and mortality among young children in developing countries.", "output": [ "background" ] }, { "id": "task1163-fc60661c5d964a8ea26db39e896e99e8", "input": "with which the present technological and managing situations are not completely compliant.", "output": [ "background" ] }, { "id": "task1163-be4d2908ff3a41c383dd325918107166", "input": "Starting in the 1960s , the human adenovirus type 12 ( Ad12 ) system has been used in my laboratory to investigate basic mechanisms in molecular biology and viral oncology.", "output": [ "background" ] }, { "id": "task1163-b0d5c86ab8514e979158c740002adc02", "input": "have been traditionally consumed in various forms by Philippinos for treatment of diabetes and kidney related diseases.", "output": [ "background" ] }, { "id": "task1163-2b6c088540db40d08d7fcc6479e66025", "input": "Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases.", "output": [ "background" ] }, { "id": "task1163-298a9cea8c674c1baa18ab2c4531cfae", "input": "The overall objective of this study was to compare the efficacy of medium-chain fatty acids ( MCFA ) to other common fat sources to minimize the risk of porcine epidemic diarrhea virus ( PEDV ) cross-contamination in a pig bioassay.", "output": [ "purpose" ] }, { "id": "task1163-8a16501031254de4a4cd8e644c2f24e1", "input": "Our results suggest that theaflavin could be the candidate of SARS-CoV-2 entry inhibitor for further study.", "output": [ "finding" ] }, { "id": "task1163-1a793fac022c4559b70beeed1769ca0f", "input": "We previously identified unusual variants of Moloney and Friend ecotropic mouse gammaretroviruses that have altered host range and are cytopathic in cells of the wild mouse species Mus dunni.", "output": [ "background" ] }, { "id": "task1163-ede1c8f929ae406bb2f7f7fb0acccdd2", "input": "These model predictions have shown a wide range of variations.", "output": [ "background" ] }, { "id": "task1163-68c1024b7c3a4dddb3cd9ed621173aa6", "input": "and to both CFT and ELISA with immune animals ( r > 0.96 ).", "output": [ "finding" ] }, { "id": "task1163-f6594e6ff87f46db9bc49d6ac0e98ac4", "input": "visited two hospitals in Mecca.", "output": [ "finding" ] }, { "id": "task1163-3043902a2f7f42f2ad51cc4990d59832", "input": "Histone acetylation changes were validated by biochemistry assays.", "output": [ "method" ] }, { "id": "task1163-3f76062f5cd243438213c2d57ce211ee", "input": "economy-class cabin of Boeing 767 and 737 airplanes.", "output": [ "method" ] }, { "id": "task1163-99f5286048e74ecc95ed81911fee955f", "input": "including opportunities to apply new science and technology.", "output": [ "finding" ] }, { "id": "task1163-194ab21f2784408baf94faf39f8cce81", "input": "and slightly higher than the SNP rate observed in human MHC ( 0.00337 SNP per bp ).", "output": [ "finding" ] }, { "id": "task1163-1409ab2b23dd4de9bce56bdb8c25a3ca", "input": "Follow-up visits were conducted for 2 years after the episode of bronchiolitis.", "output": [ "method" ] }, { "id": "task1163-450d23be3b904fdab2af30c064a59ce8", "input": "This study is aimed to understand the seasonal distribution and clinical manifestations of HCoV-NL63 infection in children in Taiwan.", "output": [ "purpose" ] }, { "id": "task1163-1fdddddf66574b0bbf5640c77e7ec8b9", "input": "and - DRB loci on the 6 common haplotypes.", "output": [ "purpose" ] }, { "id": "task1163-c52429abee3e4b138d877f07bc75d0bd", "input": "in lung tissues of smokers without airflow limitation and COPD patients in comparison to nonsmoking individuals ( never-smokers ).", "output": [ "purpose" ] }, { "id": "task1163-f3bac7ba0c694a2bbefd9063ac86e18d", "input": "with substantial associated costs and morbidity.", "output": [ "background" ] }, { "id": "task1163-c03aba1713474e02a57a92028978f7f1", "input": "Exposure to MERS-CoV during a hospital visit is considered a likely source of infection for Case 1 but not for Case 2.", "output": [ "finding" ] }, { "id": "task1163-54d6fde19cb9434c9cbe35d52621de12", "input": "Posttraumatic stress disorder ( PTSD ) can arise in patients with medical illness.", "output": [ "background" ] }, { "id": "task1163-a42fc13dd2a8432685b9d17a3a50a88a", "input": "We assessed risk of bias for each individual study and used GRADE to ascertain the certainty of the evidence.", "output": [ "method" ] }, { "id": "task1163-ed2847752cf1459e87d90402cd657e48", "input": "However , little is known about the disease burden and the molecular epidemiology of HAdV.", "output": [ "background" ] }, { "id": "task1163-e1b9682977f942819c6089587f36fbf8", "input": "Photoactivated Orthoquin inhibited herpes simplex virus type 1 ( HSV-1 ) and herpes simplex virus type 2 ( HSV-2 ) infection of target cells in a dose-dependent manner across a broad range of sub-cytotoxic concentrations.", "output": [ "finding" ] }, { "id": "task1163-d2e89ffaf94c4d168068008eca354a01", "input": "We apply this framework on two major pathogens that infect African 48 lions : canine distemper virus ( CDV ) and feline parvovirus.", "output": [ "method" ] }, { "id": "task1163-93105d64240b4436a78c61f4b96c030e", "input": "quick , and safe cell adhesion inhibition assay was developed to determine the potential cellular binding site on the SARS-CoV spike protein.", "output": [ "purpose" ] }, { "id": "task1163-c2b4c680f4594580a538973c11893f2a", "input": "pegIFN-α can be administrated , but is only suited for the subset of liver-transplant recipients ( 12 ) ( 13 ) ( 14 ) ( 15 ).", "output": [ "method" ] }, { "id": "task1163-3d52a540f7574fd18539daa21ed989e2", "input": "Purpose of the review-We describe the history of passive immunization to provide context for the series of articles to follow.", "output": [ "purpose" ] }, { "id": "task1163-e8cdeb0152e649788230d1af1ba6b09f", "input": "In addition , HAdV burden and co-infection was evaluated for samples tested in laboratory analysis packages.", "output": [ "method" ] }, { "id": "task1163-7df498dbe6884fc4aa942730e8acec9f", "input": "Furthermore , the contributions of monocyte-derived subsets to viral clearance and immunopathology are not well-defined.", "output": [ "background" ] }, { "id": "task1163-25594e54d6784bfb9999bf6eac426063", "input": "including compound structure-function studies , insect cell functionality augmentation , and VLP production.", "output": [ "purpose" ] }, { "id": "task1163-94eee5797e264ca1a725557dd020f092", "input": "But until now , SCUB analysis has been performed only in chloroplast genome of G. hirsutum ( 36 ).", "output": [ "background" ] }, { "id": "task1163-9d1545653228426ba8461af20f8f0217", "input": "human Bocavirus in patients above a year of age was more common ( p < 0.05 ).", "output": [ "finding" ] }, { "id": "task1163-6fe162a11aca462d9743502f4df20f1e", "input": "We used electron microscopy to identify murine coronaviruses with mutations in nsp3 and nsp14 that replicated normally while producing only half the normal amount of DMVs under low-temperature growth conditions.", "output": [ "method" ] }, { "id": "task1163-294dfe82fb774daf85e633565096bc37", "input": "The purpose of this study is to investigate the ongoing development of China 's PHERIS.", "output": [ "purpose" ] }, { "id": "task1163-d4998713021d431291a6479732fd942f", "input": "Utilizing the YSD technique , antigens specific to the target antibody are displayed on the surface of engineered yeast cells with intracellular fluorescent proteins.", "output": [ "background" ] }, { "id": "task1163-4843d866b27549c7842229db69b87b3a", "input": "acute myocardial injury ( AMI ) in COVID-19 patients has not been previously investigated in detail.", "output": [ "background" ] }, { "id": "task1163-2518730771394bfe8303f294e84662fa", "input": "We have also discovered that the insertion of foreign ( Ad12 , bacteriophage lambda , plasmid ) DNA into mammalian genomes can lead to genome-wide alterations in methylation and transcription patterns in the recipient genomes.", "output": [ "background" ] }, { "id": "task1163-efa2a518df274e75b2f6afe6e7af2c6e", "input": "These models allow us to derive threshold conditions that can be used to assess the effectiveness of vaccine and drug use and to determine disease outcomes.", "output": [ "background" ] }, { "id": "task1163-cc470f9a3a0f4786a8dab096f63c1b30", "input": "Attachment is followed by a redistribution or capping of virus particles on the cell surface which may play a role in the uptake process.", "output": [ "background" ] }, { "id": "task1163-81928f0c7b914513a7a9d446a43d3312", "input": "exhibited neurotropism , and were mildly neurovirulent in neonatal ddY mice.", "output": [ "finding" ] }, { "id": "task1163-c579fa0060304660a912591c85bc6781", "input": "We describe disease-pathogen associations of respiratory viruses and quantify virus-specific attributable risk of ARIs in healthy children during the first 2 years of life.", "output": [ "purpose" ] }, { "id": "task1163-73e0346b485d43aeb62bda4df606eb77", "input": "paper and hydrogels are alternatives due to their distinct structural and mechanical properties for a number of applications.", "output": [ "background" ] }, { "id": "task1163-b18817a420124ec4ba0f3fa907217fde", "input": "We have conducted a systematic review to synthesise evidence about the uptake and effectiveness of facemask against respiratory infections in MGs.", "output": [ "purpose" ] }, { "id": "task1163-b5159592741740e68e2a1f7230cd2db0", "input": "to the financial crisis and global recession of 2008 and subsequent ` austerity agenda ' of state retrenchment.", "output": [ "purpose" ] }, { "id": "task1163-5d558201ecce43389e6bb88a389321dd", "input": "In addition , it explores potential means to continue to educate trainees during the COVID-19 pandemic.", "output": [ "purpose" ] }, { "id": "task1163-bc93947d74634d828c1e5641a122a8ae", "input": "Diseases 2016 , 4 , 26 2 of 27 SARS-CoV but with a much higher mortality rate of about 35 % ( 17 ).", "output": [ "finding" ] }, { "id": "task1163-ae8db1fa4284408aace87f1c6b742db6", "input": "However , the reversible reaction used for DCL formation should equilibrate fast enough to allow re-equilibration by the target on a timescale during which the target remains stable.", "output": [ "background" ] }, { "id": "task1163-bdf42ac953604f97b490da3633f2a9a8", "input": "which is the primary purpose of the paper.", "output": [ "purpose" ] }, { "id": "task1163-58e7f9de54c74e869bb951ff1a311d62", "input": "Moreover , we show that the addition of MPA to S. cerevisiae cells leads to a reduction of capped mRNAs.", "output": [ "finding" ] }, { "id": "task1163-7d0479a9427c4736bc61538dcfb275f9", "input": "In the white matter , the reaction was moderate.", "output": [ "finding" ] }, { "id": "task1163-94889db2ea7d4ebdad096fe34c005fa0", "input": "laboratory test results , response to treatment , and relapses.", "output": [ "method" ] }, { "id": "task1163-5b9241d05efa4ffc85adf829d154875d", "input": "This study aims to determine the levels of the IL-1 family ( IL-1β , 54 IL-37 ) and IL-12 family ( IL-12 , IL-35 ) in a group of these patients and the association 55 between these cytokines levels and the patients ' demographic characteristics.", "output": [ "purpose" ] }, { "id": "task1163-a32362bdcd24405193cbe20a4fc3439c", "input": "Herein , we report the glycosylation mapping on spike protein subunits S1 and S2 expressed on human cells through high resolution mass spectrometry.", "output": [ "background" ] }, { "id": "task1163-93868dda82374b42a72315a23f1bc836", "input": "These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.", "output": [ "purpose" ] }, { "id": "task1163-5a1b6bcd08364b51b60bbde581792dcc", "input": "The sensitivity of EM increased 25 % after virus concentration by ultracentrifugation.", "output": [ "method" ] }, { "id": "task1163-c63fed3fd3144fa4b3003ddb3cec6308", "input": "Incorporating these approaches in economic analyses of AECB antimicrobial therapy can help health care organizations make evidence-based decisions regarding the cost-effective management of AECB.", "output": [ "finding" ] }, { "id": "task1163-7a27280f285749ec860f2d0e44a25a87", "input": "but to the inhibition of viral multiplication in host cells.", "output": [ "finding" ] }, { "id": "task1163-9b41bd3775a04130b69f94f5d61a9023", "input": "describes MERS vaccine criteria , and presents available small animal models to evaluate the efficacy of MERS vaccines.", "output": [ "purpose" ] }, { "id": "task1163-c6a292fdb85245e58528a9b347e63462", "input": "We consider a ` SIR ' type model for the 60 host population and a ` SI ' type model for the vectors.", "output": [ "method" ] }, { "id": "task1163-0c23dccf18e64b788790e637b5b950a5", "input": "followed by a template with details on the safety and characteristics of a rVSV vaccine against Zaire ebolavirus ( ZEBOV ).", "output": [ "purpose" ] }, { "id": "task1163-871cb37681c8471582b78e3ebc8d96ce", "input": "but also in financial time series.", "output": [ "finding" ] }, { "id": "task1163-25fa54c754a8460aa8f5fad2b62ac2be", "input": "It has been proposed that all diploid cotton species may have evolved from a common ancestor and allopolyploid cotton may have appeared through hybridization and subsequent polyploidization events between the A-and D-subgenome progenitors.", "output": [ "background" ] }, { "id": "task1163-a846cf2f26fc4390847980094676961a", "input": "In 1994 the Republic was linked directly by air with more overseas than African countries and cities ; within a decade the pattern reversed.", "output": [ "background" ] }, { "id": "task1163-fe5638b35eb64b65a973db2be29ed323", "input": "Homotypic interaction involving Domain III of MHV nsp15 was further demonstrated biochemically.", "output": [ "finding" ] }, { "id": "task1163-8991611e679948fa848f66448d747a44", "input": "Mx1 , IFN-β , and OAS-1 as compared with control MDBK cells.", "output": [ "finding" ] }, { "id": "task1163-38a6a7af741d4c4c9a932625d54e8145", "input": "The most common symptom was fever.", "output": [ "finding" ] }, { "id": "task1163-9536c6f67dc644f68d5e35fcf3cc0e28", "input": "Unlike natural populations , the structure of this panel allows the serial evaluation of genetically identical individuals and the quantification of genotype-specific effects of interventions such as vaccination.", "output": [ "method" ] }, { "id": "task1163-23a909f8d81e4520974d4f4fccd0360e", "input": "which encompasses both communicable and non-communicable diseases.", "output": [ "purpose" ] }, { "id": "task1163-89198c3906c04097913f3e3d4eeafb37", "input": "wind speed classification is derived based on Physiological Equivalent Temperature ( PET ) to evaluate the effect of wind speed on outdoor thermal comfort.", "output": [ "method" ] }, { "id": "task1163-08d74d7a60824728ad39fa88611a4308", "input": "The objective of this study was to investigate the inactivation performance of dialdehyde starch ( DAS ) treated filters against airborne viruses.", "output": [ "purpose" ] }, { "id": "task1163-e6c296109719470488a38f465db34dca", "input": "Local stability of endemic equilibria is studied.", "output": [ "method" ] }, { "id": "task1163-61d14b3839cf41859095f86b7f8cf35e", "input": "We review the techniques and guidelines that our institution has implemented in order to allow us to do just that.", "output": [ "purpose" ] }, { "id": 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confidence interval 1.39-1.62 ).", "output": [ "finding" ] }, { "id": "task1163-632c7308e974434f899f52d88d7f9a5d", "input": "The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses.", "output": [ "method" ] }, { "id": "task1163-c5bce5f943d743dbba8ddc49e106e097", "input": "and how best these can be improved within the local context.", "output": [ "finding" ] }, { "id": "task1163-9648668d2bf04662a0568182cf8062ac", "input": "especially small non-coding RNAs ( sRNAs ).", "output": [ "background" ] }, { "id": "task1163-01bd82d386204f0a97b9688839c86122", "input": "and viral RNA cosedimented with heavy membrane structures.", "output": [ "method" ] }, { "id": "task1163-a0da136cb2944fd1ac3f6fcd2d846612", "input": "However , the recent report on asymptomatic contact transmission of COVID-19 and travelers who passed the symptoms-based screening and tested positive for COVID-19 using reverse transcription polymerase chain reaction ( RT-PCR ) challenges this approach as body temperature screening may miss travelers incubating the disease or travelers concealing fever during travel.", "output": [ "background" ] }, { "id": "task1163-3bd04da163374abf92cb3247a9f33f07", "input": "The attendance number of male subjects was persistently higher than female subjects.", "output": [ "finding" ] }, { "id": "task1163-ddec68606f8841e89ce158b38c6590f4", "input": "the reporting completeness of the notifiable disease surveillance system remains incompletely assessed.", "output": [ "background" ] }, { "id": "task1163-eca9b4ef4fc440c1a97e4b08c4658f76", "input": "We highlighted the presence and the high diversity of coronaviruses circulating in bats from Cambodia and Lao PDR.", "output": [ "finding" ] }, { "id": "task1163-a5ef3432c9ce492ea70be95c6b8bcc81", "input": "In this report , respiratory infections have been discussed under the headings `` acute respiratory tract infection '' and pneumonia and acute exacerbation of chronic pulmonary diseases.", "output": [ "method" ] }, { "id": "task1163-5d382223b84f4810931b3396207756bd", "input": "Reproductive numbers were inferred with Bayesian birth death skyline analyses.", "output": [ "method" ] }, { "id": "task1163-f95b8b3d94034abe9d47f34f8e782274", "input": "including nonreplicative and vectored vaccines , have been developed.", "output": [ "background" ] }, { "id": "task1163-ab04270bafec417597af7fe5bb85065f", "input": "Thus we wanted to study how indoor environmental conditions ( enclosed locations ) in the tropics and winter temperate zones contribute to the aerosol spread of influenza by travelers.", "output": [ "method" ] }, { "id": "task1163-5c92dc100d3f4682aa3b9cfd05760db4", "input": "which activates the intracellular pathogen recognition receptor RIG-I and induces the production of proinflammatory cytokines and antiviral interferon.", "output": [ "background" ] }, { "id": "task1163-8cbc155142e14c9eaf867567ffafb0db", "input": "we evaluated the in vitro activity of a triple combination antiviral drug ( TCAD ) regimen composed of drugs with different mechanisms of action against drugresistant seasonal and 2009 H1N1 influenza viruses.", "output": [ "purpose" ] }, { "id": "task1163-d9cf30d8fc734d0da429c33c25a734ee", "input": "with collection and analysis of comprehensive clinical and epidemiological data.", "output": [ "finding" ] }, { "id": "task1163-c240962685a143b4acef6c215f1224bf", "input": "Nevertheless , the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates.", "output": [ "background" ] }, { "id": "task1163-cd968dd1efdd47de9140d7557f3cafe6", "input": "followed by an assessment of the available data on the economic impact of this disease.", "output": [ "purpose" ] }, { "id": "task1163-e804dbe823de4189bfe5c2b6fa4e52ee", "input": "Involvement was commonly bilateral with no axial or craniocaudal predominance in the distribution.", "output": [ "finding" ] }, { "id": "task1163-d7266f102a824e69aacd10b39f1437f4", "input": "The disease free equilibrium ( DFE ) of the 103 system is given by Y 0 = ( Π h µ h , 0 , 0 , Πv µv , 0 ).", "output": [ "method" ] }, { "id": "task1163-938cde46450943d98c9a697983a6dd35", "input": "including active , smoldering , or latent infections.", "output": [ "background" ] }, { "id": "task1163-165306cca85d4223b51d3ec8257dc750", "input": "a prospective model and a classification scheme for five corresponding types of self-protective behavior adopters are proposed in this study.", "output": [ "method" ] }, { "id": "task1163-1b4b903293a04f3dbef46fe4460be457", "input": "and has been routinely employed in immunoecological studies.", "output": [ "background" ] }, { "id": "task1163-c22310a07994417b94a3af6f29097291", "input": "Here , we describe an approach based on two complementary enrichment strategies that significantly improves the sensitivity of NGS-based virus identification.", "output": [ "purpose" ] }, { "id": "task1163-5dce6e2626304449994d66117b8f2606", "input": "To perform a detailed histopathological analysis of the open lung biopsy specimens from five patients with ARDS with confirmed H1N1.", "output": [ "purpose" ] }, { "id": "task1163-ea0b98caa9004aadb45dc5d41580fa31", "input": "These studies revealed a novel regulatory mechanism supporting the beneficial effects of fasting , namely , reduced inflammation.", "output": [ "finding" ] }, { "id": "task1163-a0bfe95bcc174f3a904bc55315c64954", "input": "In this study , three typical atmospheric inhaled particles in Shanghai were studied by the synchrotron based transmission X-ray microscopes ( TXM ).", "output": [ "method" ] }, { "id": "task1163-9b6c95a6fd9949769ce0c4c0ea1acb0b", "input": "Between 2010 and 2013 , 1965 bats were therefore sampled at interfaces with human populations in these two countries.", "output": [ "method" ] }, { "id": "task1163-960d760eda3d414e953f5da13985d4b5", "input": "pAPN knockout in IPI-2I cells completely 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"input": "This review summarises current knowledge about the influence of environmental factors on the survival and spread of viruses via contaminated surfaces.", "output": [ "purpose" ] }, { "id": "task1163-bc5dc1e9b8ed4832990e520bc116088f", "input": "and cardiovascular exam revealed a normal S1 and S2 with no murmurs.", "output": [ "finding" ] }, { "id": "task1163-4242f94680094df980f28c68879f0b5a", "input": "and recent applications of carbamates in drug design and medicinal chemistry.", "output": [ "purpose" ] }, { "id": "task1163-f01b6855189c408eb36b9f7065dbf7b0", "input": "Hence , here we hypothesized that trypanosome infection can affect the onset of CIA by specifically dampening specific B-cell responses and type II collagen antibody titers in DBA/1 prone mice.", "output": [ "purpose" ] }, { "id": "task1163-35bcb72efc004d05afcc29f6c7908ec9", "input": "sporulated oocysts mass applied with a vaccination cabinet in the hatchery.", "output": [ "background" ] }, { "id": "task1163-359eea4e1efa47c7a65955bc3ca5d2ba", "input": "Imaging features and their distribution were analysed and compared across the four groups.", "output": [ "method" ] }, { "id": "task1163-a881315f2094435f88edda93726600c8", "input": "The dashed line represents LOD.", "output": [ "method" ] }, { "id": "task1163-f138e284e07f4217953db9c3ae89c23c", "input": "and examined the impact of the SARS epidemic ( 69 % ).", "output": [ "method" ] }, { "id": "task1163-83c7435e04034f61ab1416b8c8a83429", "input": "animal disease data , and environmental data can ultimately be used for prioritization of the most critical locations and times for viral outbreaks in both urban and rural environments.", "output": [ "background" ] }, { "id": "task1163-93d602f363584d2baf7c2b7e0e75a7fd", "input": "plus amantadine 200 mg/day ; treatment duration was 24 -48 weeks according to HCV genotype.", "output": [ "method" ] }, { "id": "task1163-9f2650f4cf2741cca6d9bd14b32c9813", "input": "thus implying it to be a key regulatory component of the virus too.", "output": [ "background" ] }, { "id": "task1163-cc6b8dcfce304b5090a598a6a4aec585", "input": "Nine weeks post-stroke , treated rats and normal aged rats were tested on the Morris water maze task.", "output": [ "method" ] }, { "id": "task1163-48e8475d91494314a137571bf8ece02a", "input": "as ascertained by a literature review of relevant studies with data since the year 2000 and a survey of researchers in the field of childhood pneumonia.", "output": [ "purpose" ] }, { "id": "task1163-1804bd0f103e4ff5b7bc9301cda90fc0", "input": "with individual antibodies recognizing discrete states.", "output": [ "finding" ] }, { "id": "task1163-cb8b0018c2124b369c594eccd1630391", "input": "and should be considered when interpreting surveillance data.", "output": [ "finding" ] }, { "id": "task1163-17fde878691747479802e3e90ff177ab", "input": "The discovery of CCSP immunoreactivity in plasma membranes of airway lining cells prompted us to explore the possibility of enriching Clara cells by flow cytometry.", "output": [ "background" ] }, { "id": "task1163-615b018f08b24ff896404507990bbd11", "input": "together with details of their patient populations tested and diagnostic assays used.", "output": [ "method" ] }, { "id": "task1163-505af8d9f57746dbbb16e8d0548695c2", "input": "Background : Cytokines play important roles in antiviral action.", "output": [ "background" ] }, { "id": "task1163-4491082122214185bf2a45b82813f5e9", "input": "and recruited the autophagy adaptor p62/SQSTM1 and LC3 prior to cytosolic clearance.", "output": [ "finding" ] }, { "id": "task1163-89325834e2c1431a9aac2c2bb6e7bfff", "input": "This study numerically investigated the thermal effect of human body on the time-dependent dispersion of cough droplets with evaporation process.", "output": [ "purpose" ] }, { "id": "task1163-1404de8829104c7b91db8aeef4abb75d", "input": "There was no difference in hospitalization status between cases and controls.", "output": [ "finding" ] }, { "id": "task1163-e9b97d740c564da0bd4cf8dc0f13c87d", "input": "while RNA-dependent RNA polymerase ( RdRp ) sequences revealed only one clade.", "output": [ "finding" ] }, { "id": "task1163-ddcbacf173ed4004bf8159bc5dc09a96", "input": "Nicaragua and Peru among children with influenza-like symptoms enrolled in a sentinel surveillance program.", "output": [ "finding" ] }, { "id": "task1163-a0d76b6947dc4ccdbd5f5d136a26468b", "input": "NR1 , NF2 , NR2 and N350R primers.", "output": [ "method" ] }, { "id": "task1163-8de71876da9d40b99c1686198067f8cc", "input": "microbeads have facilitated the integration of other technologies such as emulsion PCR ( ePCR ) and Fluorescence Activated Cell Sorting ( FACS ) to high-throughput selection techniques.", "output": [ "background" ] }, { "id": "task1163-6563845bf1974a82b6c7e01db03bdea7", "input": "lending further support of an infectious disease cause of KD.", "output": [ "background" ] }, { "id": "task1163-1edc0ae7abfb4c4aa094760acfe63db6", "input": "Ectopic expression of pAPN in non-susceptible BHK-21 cells rendered them susceptible to PDCoV.", "output": [ "finding" ] }, { "id": "task1163-452c0cb55dd645cea33049b990be6c80", "input": "A majority of emerging infectious diseases are of zoonotic origin.", "output": [ "background" ] }, { "id": "task1163-785997be381c463ab500070a27ece5d9", "input": "thus hampering the prospects for further antiviral drug development.", "output": [ "background" ] }, { "id": "task1163-0191f81de166497d9ee0feba19eeee82", "input": "Txnip expression in vivo.", "output": [ "background" ] }, { "id": "task1163-e574e23561f048dd9a22601a1a3204f8", "input": "Accordingly , there is a need to develop a simple parameter for assessing view obstruction level.", "output": [ "background" ] }, { "id": "task1163-f7a41cc1878c4256837444286a2372aa", "input": "and severe acute respiratory syndrome ( SARS ) in Asia and West Africa.", "output": [ "purpose" ] }, { "id": "task1163-8ab8f16e536341efb749e6922cabfe6f", "input": "This paper presents an up-to-date overview and comparison of the analytical performance of sensors and biosensors recently used in clinical analysis.", "output": [ "purpose" ] }, { "id": "task1163-d9a824284ad04309b4b6d5bbfd4a4967", "input": "and a diagnostic gaps analysis.", "output": [ "method" ] }, { "id": "task1163-ea78ae23bb6b462e83e6fd40aaa7e340", "input": "which are involved in mRNA degradation.", "output": [ "background" ] }, { "id": "task1163-6edcea277d3a43e7a23635597a08fea2", "input": "This study used two cases from the literature to validate the developed model and found well agreement between the transient particle concentrations predicted by the FFD-Markov-chain model and the experimental data.", "output": [ "method" ] }, { "id": "task1163-229a206ecc2d4ae29e4b1cbbb24feae2", "input": "Fecal consistency scores were assigned each week from birth until weaning.", "output": [ "method" ] }, { "id": "task1163-6f2fcee17c1b4c758255f19c8858a214", "input": "a key determinant of their ultimate risk to public health.", "output": [ "background" ] }, { "id": "task1163-2e2050d3b7f54b3098f5fdc2deb86842", "input": "BALB/cV tumor cells lacked gp52 and expressed instead a 68K , env-related protein.", "output": [ "finding" ] }, { "id": "task1163-f9ff5ad934b84b3680e852d5b059b6b6", "input": "Here , we report the first simultaneous detection of a human respiratory syncytial virus ( HRSV ) infection in western lowland gorillas ( Gorilla gorilla gorilla ) and in the local human population at a field program in the Central African Republic.", "output": [ "purpose" ] }, { "id": "task1163-93778fc6006e46498289d916356f8e02", "input": "the largest of its kind-as many of the questions surrounding ebolaviruses have only been interrogated in the laboratory.", "output": [ "background" ] }, { "id": "task1163-ee05b3d757324b89ad3f5d14197e0e87", "input": "In this review series , the life cycle of these pathogens and the epidemiology of disease have been reviewed in the context of potential points of intervention for the prevention of human infection.", "output": [ "finding" ] }, { "id": "task1163-0ed00e88ecea4945843d0370eae0ff72", "input": "Here , we showed that ACE2 protein levels were significantly downregulated after infection with H1N1 viruses but was dispensable for viral replication.", "output": [ "finding" ] }, { "id": "task1163-4e1b8508685d4854b92f81c595b2583a", "input": "They represent also an important economic burden to health systems worldwide.", "output": [ "background" ] }, { "id": "task1163-3352d0fe7adb4690ad8c43d2fdea8d82", "input": "Negative samples also had to test negative by at least two of the three assays.", "output": [ "method" ] }, { "id": "task1163-835728752ad54082ab739f63905012a8", "input": "All mutants reacted with an antibody against the major antigenic site and bound red blood cells.", "output": [ "finding" ] }, { "id": "task1163-c3d418211cba4eeeb54d641b29b39272", "input": "This review focuses on the recent developments in generating rationally designed DNA molecules and their applications.", "output": [ "purpose" ] }, { "id": "task1163-05f9b97986944e398efc22111cd7a3e6", "input": "The four targets were amplified simultaneously in a quadruplex reaction.", "output": [ "method" ] }, { "id": "task1163-f961d359c9614d88adaece4499216e3e", "input": "The compounds NCTn ( n = 5 , 6 , 7 , and 8 ) used in this study were synthesized as previously reported ( 1 ).", "output": [ "method" ] }, { "id": "task1163-40b836f2c6334ad3ba009632a6616fc0", "input": "This study investigates the factors associated with the uptake of influenza vaccination among adults in Hong Kong aged 50-64 years.", "output": [ "purpose" ] }, { "id": "task1163-163766e4046247f5a3fd45e45bed99e8", "input": "Male PTX3 knockout ( KO ) mice and their wild type ( WT ) littermates on 129/SvEv/C57BL6 / J background were used as recipients.", "output": [ "method" ] }, { "id": "task1163-b08a80bbf89843bbb562958dd17359f2", "input": "Areas covered-This review examines various approaches used to select drugs interfering with the -1 frameshift of HIV-1.", "output": [ "purpose" ] }, { "id": "task1163-9b401bb293534d2592a6df5b7a23416d", "input": "normally separate components have been joined together via flexible linker sequences in a single polypeptide chain.", "output": [ "method" ] }, { "id": "task1163-58c2f018c03d40b5bfc2d68d63b32e8c", "input": "the FTD kits yielded rapid results in a shorter timeframe , increasing efficiency of diagnosis.", "output": [ "finding" ] }, { "id": "task1163-d1a2f3f99a0c4d27a2f53648f742f8a2", "input": "and proinflammatory interleukin 1 beta ( IL1B ) maturation.", "output": [ "background" ] }, { "id": "task1163-60ab29ad5ffc4ee08f7bc0b683d3844f", "input": "and neutralizing antibody production , indicating that this monkey model is suitable for studies of MERS-CoV infection.", "output": [ "finding" ] }, { "id": "task1163-e4881f177ca84dbca8d59839cf63eb36", "input": "Membrane insertion was explored using a cell-free system directed by transcribed mRNAs encoding amino-terminal segments of the two proteins.", "output": [ "method" ] }, { "id": "task1163-c1cfec08e2fb4a9e8074ce6b3a5f8ecc", "input": "we call for research and investment in three areas : 1 ) surveillance among wildlife to identify the high-risk pathogens they carry ; 2 ) surveillance among people who have contact with wildlife to identify early spillover events ; and 3 ) improvement of market biosecurity regarding the wildlife trade.", "output": [ "purpose" ] }, { "id": "task1163-d7f92d55d2dc4ea0adfc5ffd44a4379f", "input": "thus allowing a better understanding of infection-driven pathophysiology in vitro.", "output": [ "purpose" ] }, { "id": "task1163-c44dbae440b148f9a2d6ba7786aa6caa", "input": "second order molecular connectivity index ( 2 c ) and third order Kier 's alpha shape index ( ka 3 ) are effective in describing the antimicrobial activity of synthesized hydrazides.", "output": [ "finding" ] }, { "id": "task1163-e8c73b88957641e9b8b2e1b145afb75f", "input": "Samples were obtained from the skin lesions.", "output": [ "finding" ] }, { "id": "task1163-b2024d72964e4a99bf0e44a8ec610fcc", "input": "gene function and exogenous gene expression.", "output": [ "background" ] }, { "id": "task1163-c1a518979098478c93667107c928568a", "input": "Viral diagnoses were made by serology and/or PCR.", "output": [ "method" ] }, { "id": "task1163-29b58a2acdaa4196800d569b54508278", "input": "Therefore , the National Institute of Allergy and infectious Disease ( NIAID ) has developed and supported a variety of programs and resources to provide assistance and lower the barrier for those who undertake these difficult challenges.", "output": [ "purpose" ] }, { "id": "task1163-b8cdf9e102654565b8fa622a870b5541", "input": "which could eventually contribute to lung injury.", "output": [ "finding" ] }, { "id": "task1163-4b701836890c40b48b3a55fd7f454d6f", "input": "Astrocytes produce granulocyte/macrophage colony-stimulating factor ( GM-CSF ) and support the survival and proliferation of microglia.", "output": [ "background" ] }, { "id": "task1163-cf5408156b0140cabc7ae50ab114b2c7", "input": "All compounds proposed by our approach are classified as non-antibiotic and non-antitumor compounds in the AntiMarin database.", "output": [ "finding" ] }, { "id": "task1163-538165c514b54a6d8b61150e41c57f13", "input": "Finally , the population coverage analysis was employed.", "output": [ "method" ] }, { "id": "task1163-5082c31703fe4d05a5d122dc2138ace5", "input": "HSV genes are expressed in an ordered temporal cascade.", "output": [ "background" ] }, { "id": "task1163-7e872877eecf44b480a3f6910963a0d9", "input": "Data were analyzed as a randomized complete block design with pen as the experimental unit.", "output": [ "method" ] }, { "id": "task1163-1545ff226ea74e1e9ba0e25163275405", "input": "thereby leading to the development of new vaccines.", "output": [ "background" ] }, { "id": "task1163-77d03636c0c3487bb909ef2677768003", "input": "including bacterial adherence to eukaryotic cells.", "output": [ "background" ] }, { "id": "task1163-feb77ba0153447918a862025cc8e8ccb", "input": "however these were not considered physiologically relevant since all values were within the normal range.", "output": [ "finding" ] }, { "id": "task1163-f2c9e0746eb74a33b4f22947b230c0f4", "input": "little is known about immune reactions in birds.", "output": [ "background" ] }, { "id": "task1163-61b550a6b22d42e9b173e73fb5af8e2f", "input": "Blockade of the CEACAM1 signaling pathway has recently been implicated as a novel mechanism for cancer immunotherapy.", "output": [ "background" ] }, { "id": "task1163-923c3bb6cd1c4ccca676fe20bd74f097", "input": "MVTT is therefore an attractive live viral vector for mucosal vaccination.", "output": [ "finding" ] }, { "id": "task1163-73ea92db4ee945fab538ad2e288ea87c", "input": "Objectives : The aim of this study was to assess the effect of commercial aurintricarboxylic acid ( ATA ) against Cryptosporidium parvum.", "output": [ "purpose" ] }, { "id": "task1163-9d9fa9646ea94d13b2336e11988b8206", "input": "including phenotype , function and gene expression.", "output": [ "purpose" ] }, { "id": "task1163-9bdda2de4a384d93a1560c829075e266", "input": "BALB/c male mice were mated with either Swiss-Webster or MF1 females to produce first generation cross-bred offspring.", "output": [ "method" ] }, { "id": "task1163-cd729b08a9ff4e6e81be449a59301060", "input": "we used piecewise regression analysis to compare the blood culture rate before and after implementation of the prediction rule.", "output": [ "method" ] }, { "id": "task1163-291f43bd513c4887a70756d049917447", "input": "but very high quantities of passive antibodies are needed to restrict virus replication on mucosal surface.", "output": [ "background" ] }, { "id": "task1163-9633aba4c6524fc78503681e73f57f9f", "input": "and measuring patients ' knowledge of primary healthcare centers ( PHCCs ).", "output": [ "purpose" ] }, { "id": "task1163-2a42a994a84b4ead8ab14d3be1851f76", "input": "He was intubated and sedated.", "output": [ "method" ] }, { "id": "task1163-ad32c1afc4024b518cba9ad1492eed4e", "input": "providing clues to explain the usage of pAPN by PDCoV.", "output": [ "finding" ] }, { "id": "task1163-62df29268d57409cb26367da3bed0d9b", "input": "The PanCoV-RT-PCR assay can be a useful tool to detect CoV samples from diarrheic calves.", "output": [ "finding" ] }, { "id": "task1163-909590b6dc38440bbb61e9e2a65a5e65", "input": "toxicology , and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action.", "output": [ "purpose" ] }, { "id": "task1163-13875ed80815416888c827b6d0718e6f", "input": "We considered plant-disease pairs of words as units of information available in a medical system based on the use of medicinal plants.", "output": [ "method" ] }, { "id": "task1163-53d7d3c972d14148b04300941f79d9d6", "input": "To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36 %.", "output": [ "background" ] }, { "id": "task1163-9ee1ecb2990f440ca11a53151966c78c", "input": "thus representing viable targets for drug therapy.", "output": [ "finding" ] }, { "id": "task1163-8490ee3e826b488bb6131f22b71e7df0", "input": "Whether E can release from cells or E/N interaction exists so as to contribute to enhanced VLP production is unknown.", "output": [ "background" ] }, { "id": "task1163-cd2dad27d9c04321a41f3204995dd2d5", "input": "and group 4 ( > 2 weeks to 3 weeks ).", "output": [ "method" ] }, { "id": "task1163-fbfe84cad2b14a0384bea512c7e3a48c", "input": "with important implications for disaster and crisis management.", "output": [ "purpose" ] }, { "id": "task1163-ef48f58002654b90ae7b50c9c0d8acea", "input": "health centers and quarantine stations nationwide were implemented.", "output": [ "background" ] }, { "id": "task1163-5fc847b8f95241d094e33072fb6d5bc0", "input": "Non-self , virus-derived RNA species have been identified as the PAMPs of RNA viruses.", "output": [ "background" ] }, { "id": "task1163-5b15e40debf64776b7d7983bb80feb12", "input": "Fecal samples were collected at multiple time points post-vaccination to quantify vaccine oocyst shedding.", "output": [ "method" ] }, { "id": "task1163-3fe6b76108714a37ade2c7d532899ff8", "input": "containing feces of the infected pigeons.", "output": [ "method" ] }, { "id": "task1163-4e4bb22ff1bc40578519c553d3995689", "input": "and to demonstrate the clearance effects of this mineral against Porcine reproductive and respiratory syndrome virus ( PRRSV ) in experimentally infected pigs as an initial step towards the development of a feed supplement that would promote immune activity and help prevent diseases.", "output": [ "purpose" ] }, { "id": "task1163-8625ff2cff924bf5a895b279938717e4", "input": "The present study assessed the inhibitory effects of a combination of clindamycin and interferon alpha ( IFN-α ) formulation against P. gulae and periodontal disease.", "output": [ "purpose" ] }, { "id": "task1163-2bc4585b089b45dc81b5f5e75f71023d", "input": "indicating that O-antigen-lacking Francisella are controlled by autophagy.", "output": [ "finding" ] }, { "id": "task1163-104a022b409c4fc09a387f5167707db2", "input": "He did not have any rashes.", "output": [ "finding" ] }, { "id": "task1163-83107eb80d104511af6e231b1b95daa1", "input": "and mechanical ventilation were the most common areas of focus for the articles retrieved.", "output": [ "finding" ] }, { "id": "task1163-561a35c87f0f41809c0e951cc8269a67", "input": "We compared all virological characteristics between the local and imported cohorts.", "output": [ "method" ] }, { "id": "task1163-199c7ef770294a49b0a5e647afe23f19", "input": "However , treatment with APN-specific antibody and inhibitors did not completely block PDCoV infection in IPI-2I porcine intestinal epithelial cells.", "output": [ "finding" ] }, { "id": "task1163-f1666d9624034da085c936e536c2d5ab", "input": "Given the endemic region , it is possible that MERS-CoV could spread during the annual Hajj pilgrimage , necessitating countermeasure development.", "output": [ "background" ] }, { "id": "task1163-00befba21fd14c57b4eaef891bbf5553", "input": "brain , kidney and liver following exposure to a range of stress insults including ischemia/reperfusion.", "output": [ "purpose" ] }, { "id": "task1163-cdd8751f116e49ab9cab1e889bb3663e", "input": "Then the proposed epitopes were subjected to Population coverage analysis tool to compute global population 's coverage.", "output": [ "method" ] }, { "id": "task1163-c1b06bccc81d4feaa97a7a3bfec27521", "input": "G. hirsutum ( AD 1 ) and G. barbadense ( AD 2 ).", "output": [ "background" ] }, { "id": "task1163-2120c014934c4c6d9c880618e1c0170e", "input": "Herpes simplex virus ( HSV ) infection of mice can induce viral encephalitis.", "output": [ "background" ] }, { "id": "task1163-5bb03769022849c68c292c6dd1944f4e", "input": "sera from 240 healthy dogs and from 3 experimentally CCV-infected dogs were examined.", "output": [ "method" ] }, { "id": "task1163-86b8d117527e4efcbc20dcf9a9502000", "input": "perceived the risk becoming ill when infected as higher than others.", "output": [ "finding" ] }, { "id": "task1163-1dd84517876c49508d1af8c03882ea66", "input": "and sequence comparison with that reported in GenBank revealed that the M gene complete sequence shares more than 94 % homology in nucleotide.", "output": [ "finding" ] }, { "id": "task1163-c86ab66b48aa4cf7a0432482eafb00ca", "input": "e.g. as a supportive means in antibiotic treatments and for prevention of hospital infections.", "output": [ "background" ] }, { "id": "task1163-e1231ae84dd046a3bd0f822f6491c7c8", "input": "Available statistical programs for reference gene ranking should include more robust analysis capability to analyse the gene expression data generated from factorial design experiments.", "output": [ "finding" ] }, { "id": "task1163-6c77d46a0d6548cd8dd516505f583c3b", "input": "Recombinant HA proteins were expressed and purified as previously described ( Benjamin et al. , 2014 ) ELISA binding assays were performed using 384 well plates ( Maxisorp , Nunc ) with 0.5 µg/ml of purified HA protein as described in Table S2.", "output": [ "method" ] }, { "id": "task1163-b2d016bb5c6e4fa3a4fc28e9105cfe6d", "input": "because of concerns about privacy.", "output": [ "background" ] }, { "id": "task1163-436212dcd8204674a11384279086da16", "input": "Continuing exposure can maintain inflammation in the nose and lungs.", "output": [ "finding" ] }, { "id": "task1163-be4eca55c6314c3fb2a3d27968f7b3b8", "input": "In this article a compartmental genetic-epidemiological model was developed to quantify the impact of host genetic diversity on epidemiological characteristics of diseases transmitted through a contaminated environment.", "output": [ "purpose" ] }, { "id": "task1163-79a8b9869300498d98f526676df8105f", "input": "The presence of the SARS-CoV-2 in the conjunctival sac of affected patients is also reported by a nonpeer-reviewed retrospective cohort study ( 7 ).", "output": [ "background" ] }, { "id": "task1163-e47f1741dc8645c49ee6473cd3374ff0", "input": "we also examined the solution-state structural dynamics of the enzyme in complex with a covalently bound vinyl sulfone inhibitor ( K777 ).", "output": [ "method" ] }, { "id": "task1163-46625c36b447486ebed8b295a8ac1eac", "input": "We examined news and current affairs items broadcast on 5 free-to-air Sydney television channels between April 25 2009 ( the first report ) and October 9 ( prior to the vaccine release ) for statements about ( 1 ) the seriousness of the disease ( 2 ) how the public could minimise contagion ( 3 ) government responses to emerging information.", "output": [ "method" ] }, { "id": "task1163-d97a48d44cb24d38bcd5c1c32aa34838", "input": "We evaluated the frequency and severity of metapneumovirus ( HMPV ) and coronavirus ( HCV ) infections in a high-risk group of infants.", "output": [ "purpose" ] }, { "id": "task1163-c62aaba83e5f4405be14500d3d9933b4", "input": "In this review we summarize the latest research studies about the most-active EOs that are known and used because of their antimicrobial properties.", "output": [ "purpose" ] }, { "id": "task1163-fea1594bc13e4b74b4c56c4cae9ea27a", "input": "In this paper , we study epidemic spreading in metapopulation networks wherein each node represents a subpopulation symbolizing a city or an urban area and links connecting nodes correspond to the human traveling routes among cities.", "output": [ "purpose" ] }, { "id": "task1163-2f6162f13105487182d4404945c70383", "input": "This virus also was found in patients with severe acute respiratory syndrome ( SARS ).", "output": [ "background" ] }, { "id": "task1163-4f3a26fbbaba4c16a826310121aea9a1", "input": "A nucleotide variability in the sequence of the gene encoding for the transmembrane protein M of canine coronavirus ( CCV ) is described.", "output": [ "purpose" ] }, { "id": "task1163-ffb569076878459a8bfdd5675986984b", "input": "a model virus being developed as a vector for anti-RSV vaccine.", "output": [ "purpose" ] }, { "id": "task1163-fa9b440aa9304215a2f6eb2292a0d2f6", "input": "implying that SAT05fmediated inhibition on IFN-α production could be related to the activation of pDCs.", "output": [ "finding" ] }, { "id": "task1163-5bf76cc035f040dc925728fb6fe61b84", "input": "( which was not peer-reviewed ) The copyright holder for this preprint.", "output": [ "finding" ] }, { "id": "task1163-9a849a4c5eb940b68ae67552e7c55c18", "input": "Methods : This was a mixed-method observational study.", "output": [ "method" ] }, { "id": "task1163-76c1be17cded45d6bd4689020908d6dc", "input": "the probability of introduction through animal purchase and local transmission.", "output": [ "method" ] }, { "id": "task1163-adcc6177826448619750ea680f0425bb", "input": "explore contributing factors , and suggest studies to better understand super-spreading.", "output": [ "purpose" ] }, { "id": "task1163-f930241e13c84e27821d2a3ca3673f86", "input": "we have identified a viral receptor and a viral nonstructural protein that are essential for hematogenous reovirus dissemination.", "output": [ "finding" ] }, { "id": "task1163-1042c2839e6046ab87a4a5fb4f0701f6", "input": "purified by affinity chromatography and used to develop an ELISA method to detect antibodies against PToV.", "output": [ "method" ] }, { "id": "task1163-6e60cfc3d7cc45e8b690693f45c1c425", "input": "In this review , we summarize the incidence of contamination of RD-114 virus in live attenuated vaccines and potential risks of infection with RD-114 virus in dogs.", "output": [ "purpose" ] }, { "id": "task1163-1b5e4a7a6a614f02a87bcdff1bc7c58a", "input": "and demonstrated that there are no universally conserved priming sequences among viruses and that it could require an unfeasibly large number of primers ( $ 3700 18-mers or $ 2000 10-mers ) to generate amplicons from all sequenced viruses.", "output": [ "finding" ] }, { "id": "task1163-df2891efb4504d08bd386f4c2cf1eec2", "input": "This study addresses the question of whether clinical variability in PRRS results from ( a ) genetic variation among viral isolates and/or ( b ) variation in management practices among farms on which isolates are found.", "output": [ "purpose" ] }, { "id": "task1163-d9117e273464470da907b0cce3f0b133", "input": "O or SAT2 , had the highest prevalence of overall viral detection in the dorsal nasopharynx ( 80.95 % ) and dorsal soft palate ( 71.43 % ).", "output": [ "method" ] }, { "id": "task1163-a88445e6074848ada4150bce7c1e8b0d", "input": "gastrointestinal , vector-borne , blood-transmitted and sex-transmitted , or mucocutaneous.", "output": [ "method" ] }, { "id": "task1163-cff1febc2cdc49abb25a50d903afc65f", "input": "A spontaneous neurological disease in cats characterized by behavioural and motor disturbances was investigated by clinical , morphological and immunological methods.", "output": [ "background" ] }, { "id": "task1163-619ce3ae19b14d29bc7fcd09ebeebf06", "input": "Fusion of viral and host membranes enables delivery of the viral nucleocapsid and tegument proteins to the cytoplasm.", "output": [ "background" ] }, { "id": "task1163-94fb3ad45e7c40d0a2e8acb45d3e4ace", "input": "We use these aggregate measures to summarize the resistance pattern for each country and to study the extent of correlation between countries ' patterns of drug resistance.", "output": [ "method" ] }, { "id": "task1163-571e077c2dcd4bda8c497c00f25a5ffe", "input": "TLM is worth of application in the clinical practice.", "output": [ "finding" ] }, { "id": "task1163-99a3453a91014612aae0bfc730ad2f57", "input": "Urinalyses from records were available for 9 of the necropsied animals and blood and urine samples from 23 free ranging and captive Iberian lynxes were prospectively obtained in order to evaluate the renal function of the living population.", "output": [ "method" ] }, { "id": "task1163-f1371a69ed0642df8b286038722a9f6b", "input": "We think that this information will shed light on the rational development of new vaccines and treatments.", "output": [ "finding" ] }, { "id": "task1163-dcfdda201cc541d9856f2a520d374a98", "input": "• The phylogenetic trees of different stock indices are presented and provide obvious phenomenon.", "output": [ "method" ] }, { "id": "task1163-0b242507203c4a2fb36768ff5ed34e28", "input": "without sufficient knowledge amongst pet owners or public health institutes.", "output": [ "background" ] }, { "id": "task1163-2f838fe87a09482b8300ff92c4083d21", "input": "In addition , ef cient cell-to-cell fusion is not necessary for virulence.", "output": [ "finding" ] }, { "id": "task1163-c20f7fcd85264323a45d7fff07580edd", "input": "reference is made to law cases which often settle view disputes by the extent of daylight obstruction.", "output": [ "background" ] }, { "id": "task1163-1eaad25f15c3484f9363ef115682c9e2", "input": "The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.", "output": [ "purpose" ] }, { "id": "task1163-75608faf74b54af6903d621efc83c551", "input": "Increased production of IgY associated with the later phases of infection was observed in most individuals around 20 dpi and culminated 30 dpi.", "output": [ "finding" ] }, { "id": "task1163-a55f002bc0a94cf1b2ad295580229754", "input": "with 2 different sets of factors likely to have contributed to the dispersal of the different viruses.", "output": [ "method" ] }, { "id": "task1163-29fd6ca1a27f458a9c7b2477d8f4c18c", "input": "this is the first clinical description of an infection by P. cordatum causing severe feline enteritis.", "output": [ "finding" ] }, { "id": "task1163-6e3d305b3a2848468a566e0bccee251e", "input": "To critically appraise the efficacy and safety of Kangfuxinye enema combined with mesalamine for the ulcerative colitis ( UC ) patients and in addition to grade the quality of evidence by using the GRADE ( grading of recommendations , assessment , development , and evaluation ) approach.", "output": [ "purpose" ] }, { "id": "task1163-0f247d78be674264ae35a65023e72424", "input": "Using this virus , complexes of SARS-CoV E and other proteins were purified using a tandem affinity purification system.", "output": [ "method" ] }, { "id": "task1163-80b26c5d10c8469b8fd3bbf1239c7dff", "input": "current study reveals severity of viral respiratory tract infections and release tips for handling them.", "output": [ "finding" ] }, { "id": "task1163-e4af29516dab4d908aa3d37feb62db4a", "input": "and I v.", "output": [ "method" ] }, { "id": "task1163-6b4f26a0407c423ab2f417512822982b", "input": "Conclusions and Clinical Importance : BCoV was more likely to be detected in diarrheic than healthy calves.", "output": [ "finding" ] }, { "id": "task1163-85deee7d530d41d98c775cb9bc1c1a50", "input": "They were divided 58 into two groups ; group I : healthy controls ( n = 70 ; median age 25 years ( range 12 to 70 59 years ) ).", "output": [ "method" ] }, { "id": "task1163-99bf631f2a6b4c66833af98b8e0adecf", "input": "Using the clone , we were able to insert a DENV4 type-specific epitope recognized by primate MAb 5H2 into envelope ( E ) protein domain I ( EDI ) of DENV1 and recover a viable chimeric recombinant virus.", "output": [ "finding" ] }, { "id": "task1163-8629b503fe304bef96e456a0b23fb308", "input": "Here , we use structured literature searches to review the virulence of each of the 214 known human-infective RNA virus species.", "output": [ "method" ] }, { "id": "task1163-fae4d73c09ac4965b8c926b368b9b279", "input": "A total of 539 NPAs were collected.", "output": [ "method" ] }, { "id": "task1163-a50ca20f9b064f46a54fecc439535249", "input": "An estimated 6.5 % of underlying pneumonia and influenza deaths were attributable to influenza.", "output": [ "finding" ] }, { "id": "task1163-b8991d9d1d3840a7a67a228a8dd72789", "input": "Here , we describe the first 23 structure of GAA , at 1.7 Å resolution.", "output": [ "purpose" ] }, { "id": "task1163-7094301ce52647bfab5632ef02e69e48", "input": "is priced in pharmaceutical companies ' stocks in the United States.", "output": [ "purpose" ] }, { "id": "task1163-64f2264d06b14624868db605a08d77bc", "input": "representativeness , and biases in the study designs.", "output": [ "background" ] }, { "id": "task1163-cfa14f53bec844ad97da54a5f931ae72", "input": "we prospectively screened children admitted to the hospital with respiratory tract infection from May 2004 to April 2005.", "output": [ "method" ] }, { "id": "task1163-b9e5d4e862374f1997c4e3fa9de3bb42", "input": "altered airway microbiome , and environmental factors.", "output": [ "background" ] }, { "id": "task1163-f3e218f1bd39453290fccc0825874b88", "input": "such as ammonium chloride ( NH 4 Cl ) , as seen for orthomyxoviruses.", "output": [ "purpose" ] }, { "id": "task1163-8c3ac6fe1b3d41fdb932340bd4f08841", "input": "The aim of the model is to understand the key mechanisms of SARS-CoV infection dynamics during the first 24 hours post infection.", "output": [ "purpose" ] }, { "id": "task1163-e99d507e22854f559277dbffca892680", "input": "likely acceptance of the pandemic ( H1N1 ) 2009 vaccine and issues relating to uptake and perceived safety.", "output": [ "method" ] }, { "id": "task1163-cfa76bdbcd834fa98d1f91d1aa875284", "input": "or when the enzyme used in assays is at concentrations below the equilibrium dissociation constant of the 3CLpro dimer.", "output": [ "method" ] }, { "id": "task1163-eb86ed5169894060b241a53e4e373307", "input": "bacteria , and eukaryotic parasites.", "output": [ "purpose" ] }, { "id": "task1163-4fed3b154a06458ba9c66d178d4a3854", "input": "15 severe cases as well as 40 moderate cases of COVID-19 patients were retrospectively analyzed.", "output": [ "method" ] }, { "id": "task1163-09b303afc97c40a6a75f7730d8f00234", "input": "In this study , we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction.", "output": [ "method" ] }, { "id": "task1163-6d091c90f6bd478599657099e45a7807", "input": "Compound 5f was found to be the most potent antifungal agent.", "output": [ "finding" ] }, { "id": "task1163-93586b302e204ca19411a31394d39ad1", "input": "This , in turn , will aide in the development of new and improved vaccine candidates.", "output": [ "purpose" ] }, { "id": "task1163-20250070b4da4df8964ef803664c8c80", "input": "namely covalent , non-covalent , and non-interacting.", "output": [ "finding" ] }, { "id": "task1163-3881e1b867aa43bc94d775335fe8362c", "input": "Records of virus shedding by cats before treatment provided a retrospective control : significantly more cats stopped shedding virus after Mutian X than recovered from infection during the control period ( p < .00001 ).", "output": [ "finding" ] }, { "id": "task1163-e217872fa0dc4e52b5b7ca2e9827f4a8", "input": "suggesting that σ1s facilitates apoptosis of reovirus-infected intestinal epithelial cells.", "output": [ "finding" ] }, { "id": "task1163-a2299e0942c04b42915f6f0880e47ef3", "input": "Herein , we report on an intranasally administered biocompatible polyanhydride nanoparticle-based IAV vaccine ( IAV-nanovax ) capable of providing protection against subsequent homologous and heterologous IAV infections in both inbred and outbred populations.", "output": [ "purpose" ] }, { "id": "task1163-dc299a21395f47ea905f4ce63129a2be", "input": "Oropharyngeal swabs were collected from children B5 years of age presenting with ARTI.", "output": [ "method" ] }, { "id": "task1163-ca3cfb340f4543c3a56ac2767b69ab95", "input": "and presented results graphically for easy communication.", "output": [ "method" ] }, { "id": "task1163-5cbf0117bbf74a9681a47a6685c315eb", "input": "Furthermore , 662 of the top 1000 articles could not be found using any of the basic critical care search terms.", "output": [ "finding" ] }, { "id": "task1163-4cce550db9fa45fc88f8a9eb31ef6354", "input": "The GMP moiety is then transferred to the diphosphate end of the RNA transcript in the second step of the reaction to form the Gppp-RNA structure.", "output": [ "background" ] }, { "id": "task1163-268d4502da444e24819105b7a709c286", "input": "In fact , reported cases of MERS-CoV often stem from outbreaks within the Middle Eastern countries or recent travel to the region ( 18,19 ).", "output": [ "finding" ] }, { "id": "task1163-3c527d22426548838bc06c27a08d5e77", "input": "As such , multiplexed PCR assays have become standard in many virology laboratories.", "output": [ "background" ] }, { "id": "task1163-69f57f05158f4f34ac899a2b6911fafc", "input": "Reads from environmental microorganisms were also identified.", "output": [ "finding" ] }, { "id": "task1163-c78b03138d5644b4a6ef4a74c369cb49", "input": "The results show that C8 adsorbs strongly on the bilayer surface.", "output": [ "finding" ] }, { "id": "task1163-26201c9ae70d4215adc44787f7946697", "input": "A retrospective chart review of 323 hospitalized patients with COVID-19 in Wuhan was conducted.", "output": [ "method" ] }, { "id": "task1163-5721ac66b7c847af969116d4a5234423", "input": "from asymptomatic or mildly ill to severe respiratory illness including death.", "output": [ "background" ] }, { "id": "task1163-acea6e548e1d44ee98b61547c14c8aa5", "input": "Phylogenetics is a powerful approach in finding evolution of current day species.", "output": [ "background" ] }, { "id": "task1163-ec1592247a5347cb81c98b4784a9a195", "input": "Accordingly , pathogenic viruses that replicate in the cytoplasm have evolved mechanisms to circumvent IFIT1 restriction and facilitate infection of mammalian cells.", "output": [ "background" ] }, { "id": "task1163-37b53cee32b346c1b6344544e441eb17", "input": "and discuss advances that can be offered by application of next-generation sequencing technology.", "output": [ "method" ] }, { "id": "task1163-d246fe228a8b4576b866988f72d20161", "input": "Estimation of the basic reproduction number by means of mathematical modeling can be helpful for determining the potential and severity of an outbreak and providing critical information for identifying the type of disease interventions and intensity.", "output": [ "background" ] }, { "id": "task1163-6235b5df655148eeb3f4d4cd0107f1a0", "input": "Moreover , 71 % ( 5/7 ) of calves from the FPT group showed IgG1 seroconversion to BCoV compared to 29.4 % ( 5/17 ) of animals from the APT group.", "output": [ "finding" ] }, { "id": "task1163-9c6c8627085341339159d1fd480c50bd", "input": "In this study , we examined self-reported frequency of occupational infection and needlestick injury among the clinical laboratory workers in Al-Madinah , Saudi Arabia.", "output": [ "purpose" ] }, { "id": "task1163-b42ea333a2a74498b89086b68acef37e", "input": "All rhesus macaques infected with Ebola virus/H.", "output": [ "finding" ] }, { "id": "task1163-5240a6ae9593400a9d3b9acdac0fadc7", "input": "while AQ 11 was the most active and selective molecule on the tested tumor cells.", "output": [ "finding" ] }, { "id": "task1163-8db4ec3f6c994773841787da4124cd72", "input": "An infection screen revealed coronavirus infection.", "output": [ "background" ] }, { "id": "task1163-db6ba12fbc03423da2903a9c6b8818aa", "input": "The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities.", "output": [ "background" ] }, { "id": "task1163-9ae1e31e28c84db39c9c47b0fc5b8d8b", "input": "The two group sizes were 31 or 11 pigs/pen ; floor space was modified so area/pig was equal between the group sizes ( 0.42 m 2 / pig ).", "output": [ "method" ] }, { "id": "task1163-01f7779cae4e459b87bc512c868b28e0", "input": "We present a simple concept for rapid development of new antimicrobials.", "output": [ "purpose" ] }, { "id": "task1163-fedad1661a3e4766a940abf4a0373bf4", "input": "An epidemiological study has been carried on at the Amiens ' Gynecology-Obstetrical center with the aim to determinate the aetiology of acute gastrointestinal disorders who affeeted part of the newborns over a two months period.", "output": [ "purpose" ] }, { "id": "task1163-1fd24fd9d2b848c8bcdc789b7184994e", "input": "and cleavage by cyanogen bromide at an engineered methionine adjacent to the desired N-terminus.", "output": [ "background" ] }, { "id": "task1163-9bfb4fbfc55b440f8c74cb4a19e8b018", "input": "placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I ™ ( currently marketed as Halo ™ ) in the prevention of URIs.", "output": [ "purpose" ] }, { "id": "task1163-80dddb7907664b5ba81e4ba2b99184a8", "input": "The evolution of the virus appears to mainly occur through purifying selection but also through recombination.", "output": [ "finding" ] }, { "id": "task1163-c0cd34962afb44b79808e6655eaaa0b3", "input": "causing disease and economic losses in the cattle industry worldwide.", "output": [ "background" ] }, { "id": "task1163-48aa14b326c248db876f33cbf883e5f3", "input": "We analysed a case of high fever that happened 2000 years ago in Biblical time and discussed possible etiologies.", "output": [ "purpose" ] }, { "id": "task1163-edde43b4a6c5412299a2a7d32d55511f", "input": "Our goal is to 45 develop a simple mathematical model that capture a range of disease dynamics with multiple mode of 46 transmissions.", "output": [ "purpose" ] }, { "id": "task1163-00ec9cd429634adbbe7333125b2a3dfc", "input": "Autophagy flux was observed using chloroquine as an inhibitor of the autophagic process.", "output": [ "method" ] }, { "id": "task1163-c5c85446e6e345b18bc74a16339b1004", "input": "We conducted a literature review of studies ( n = 12 ) in experimental animals and human subjects ( n = 11 ) and evaluated the evidence regarding the impact of administration of ACEIs and ARBs on ACE2 expression.", "output": [ "purpose" ] }, { "id": "task1163-b61fdb8b5442427686e98316778f0625", "input": "In this study , we describe the development of a large-scale automatic multi-functional isolation chamber for use with medium-sized laboratory animals carrying infectious diseases.", "output": [ "purpose" ] }, { "id": "task1163-74fa504600134cf793472f2939c074f7", "input": "• We apply the information categorization method and succeed to classify the financial markets.", "output": [ "method" ] }, { "id": "task1163-bede5d99beb44d4cbe8989947bc809a7", "input": "The extracted total nucleic acids were used to construct the libraries for deep sequencing according to the protocol of Ion Torrent platform.", "output": [ "method" ] }, { "id": "task1163-f6c9be6cdbbc4bc993878685910c0bee", "input": "The results of this project indicate that all vaccine applications are effective at protecting against Eimeria maxima challenge when using a proper dose of vaccine that allows for repeated oocyst cycling in the litter post-vaccination.", "output": [ "finding" ] }, { "id": "task1163-129bdb47880449f0b25c169ab06e818b", "input": "We aim to investigate whether survival had improved in the setting of recent advances in intensive care unit ( ICU ) management.", "output": [ "purpose" ] }, { "id": "task1163-a0a5eac24ce142f6b16aff926a5db9f4", "input": "particularly small populations , is endangered.", "output": [ "finding" ] }, { "id": "task1163-27e25ad9b4a24c36ba966a8a0244abf9", "input": "47 , 32 and 19 kDa provided the most sensitive and specific reactions.", "output": [ "finding" ] }, { "id": "task1163-ce558423fcf648bcb96d41c3241728a7", "input": "a gelatin filter , and a glass fiber filter , in a laboratory setting.", "output": [ "purpose" ] }, { "id": "task1163-a5b67c9149a942cfbb352ff9bf5e65fe", "input": "Here , we explore whether XMRV is an authentic human pathogen in the light of recent findings that indicate otherwise.", "output": [ "purpose" ] }, { "id": "task1163-526eec11e9c7407aa6d63062679f144f", "input": "We show here that oxidoreductasemediated modulations of the cell surface thiol status affect the enzymatic activity of APN.", "output": [ "purpose" ] }, { "id": "task1163-ebe732254cf84a019dec6ccafbc13108", "input": "Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses.", "output": [ "background" ] }, { "id": "task1163-81ed9722085f4dec9104b0f6fd71be47", "input": "Greece and France and later throughout Europe by land.", "output": [ "background" ] }, { "id": "task1163-2eafb311c9544e12998b5ac653269bb0", "input": "and serology ( microneutralization assay ).", "output": [ "purpose" ] }, { "id": "task1163-222f99f6fbdd47f6b758289ab9534b02", "input": "One of these changes results in assembly of two heptad repeat sequences ( HRA and HRB ) from each protomer into a six-helix bundle ( 6HB ) motif.", "output": [ "background" ] }, { "id": "task1163-d9af1f73b05c40349a11dec96c44bc34", "input": "interstitial disease , pleural effusion , and hilar adenopathy.", "output": [ "method" ] }, { "id": "task1163-fcde55003c9346d79a92e82a044882e2", "input": "Transcriptome analysis of persistently infected pharyngeal tissues by qRT-PCR for 14 cytokine genes indicated a general trend of decreased mRNA levels compared to uninfected control animals.", "output": [ "finding" ] }, { "id": "task1163-41ebd05b52974ddeac7c9114a153241c", "input": "It has been observed that the Ser139-Leu141 loop forms a short 3 10 - helix that disrupts the catalytic machinery in the inactive monomer structure.", "output": [ "background" ] }, { "id": "task1163-6da82ce5a6a14ef1800455f985a04178", "input": "Processes of the fresh air and the refrigerant are studied.", "output": [ "method" ] }, { "id": "task1163-fceedacd780c4ef394f0f76c0ae1b554", "input": "and his conjunctivae were injected.", "output": [ "background" ] }, { "id": "task1163-b31576ae3db146c1936ef0119dbc8abb", "input": "The observations that Lymphopenia is common in severe acute respiratory syndrome ( SARS ) patients and that peripheral blood mononuclear cell ( PBMC ) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection.", "output": [ "background" ] }, { "id": "task1163-d7e564bd42ef438e96f5246d9b120515", "input": "Nasopharyngeal swabs were obtained at baseline and at the end of the study.", "output": [ "method" ] }, { "id": "task1163-b63b9b7f7a874e0380c5f4c4d2a13bed", "input": "has been widely used as a pharmacological tool in preclinical studies to inform on CEACAM1 pathway biology although limited data are available on its CEACAM1 blocking characteristics or pharmacodynamic-pharmacokinetic profiles.", "output": [ "background" ] }, { "id": "task1163-ecee79c90e614138b79c68829e33f68e", "input": "Cyclophilin A has attracted attention recently as a new target of anti-human immunodeficiency virus type 1 ( HIV-1 ) drugs.", "output": [ "background" ] }, { "id": "task1163-d078684e60c54b429d52f51ff0884ca6", "input": "to understanding how the multilayer nature of the network affects processes and dynamics.", "output": [ "purpose" ] }, { "id": "task1163-a6a67fecf12e4ece9884d889625b7c75", "input": "TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome ( SARS ).", "output": [ "background" ] }, { "id": "task1163-09be7e66d7724fd696b448b3481f6a29", "input": "derived from the 5 ¢ end of the genomic RNA.", "output": [ "method" ] }, { "id": "task1163-a6b686e8a0934b8f86d528e3e7bd068b", "input": "The developments in sequencing technology and bioinformatics have outpaced the capacity to analyze and interpret the sequence data.", "output": [ "background" ] }, { "id": "task1163-fbb6340942a94a2b8c9ab7cd1b01f8aa", "input": "PLpro translationally samples the open and closed conformation of BL2 loop on a picosecond-nanosecond timescale but does not reproduce the peptide bond inversion between loop residues Tyr269 and Gln270 that is observed on inhibitor GRL0617 binding.", "output": [ "finding" ] }, { "id": "task1163-1418b1c980eb4ea8bce544ba766af606", "input": "observed worldwide or very specifically in certain regions only.", "output": [ "background" ] }, { "id": "task1163-a703b1fb23f84a7dbb552bba43806546", "input": "Accuracy of procalcitonin to discriminate between viral and bacterial pathogens was calculated.", "output": [ "method" ] }, { "id": "task1163-8d26bdd27f5041c796a3653c2fd516bc", "input": "a clinical and virological survey was conducted in adult and paediatric patients with ILI referred to two French University hospitals in Paris and Tours.", "output": [ "purpose" ] }, { "id": "task1163-90ebdcd1012547cbaad0fd047f2ff17e", "input": "This review discusses aspects on pathogenesis and diagnostic methods for IBV infection.", "output": [ "purpose" ] }, { "id": "task1163-fcc7dc103695484ea7f5205dda3827d3", "input": "This genomic RNA acts in three capacities during the viral life cycle : ( 1 ) as an initial RNA of the infectious cycle ; ( 2 ) as a template for replication and transcription ; and ( 3 ) as a substrate for packaging into the progeny virus.", "output": [ "background" ] }, { "id": "task1163-a8130f7d2af24f1e8e1ce7f3a20fce1f", "input": "and to invite 4 individuals they had met face to face in the preceding 2 weeks.", "output": [ "method" ] }, { "id": "task1163-4afa1d6ad49249caa8b7f6ea9d19935e", "input": "elevated lactate , and acidosis.", "output": [ "finding" ] }, { "id": "task1163-5d2400b1219b44eda27584bb5a04e50e", "input": "the prevalence of the CIRD virus infections could not be assessed.", "output": [ "finding" ] }, { "id": "task1163-155730b544f34480a98ab1031b7ae2fb", "input": "over the responsibilities that used to belong to MPSS.", "output": [ "finding" ] }, { "id": "task1163-8232269de75d4999bcce703e879940a3", "input": "Novel infectious diseases continue to emerge within human populations.", "output": [ "background" ] }, { "id": "task1163-533590d686f349abaa074489a10d8305", "input": "This new platform has a high potential to be integrated into microfluidic detection systems to enable portable diagnostics in the future.", "output": [ "finding" ] }, { "id": "task1163-079b91e8d3b44992b7a94b4fa39d74d2", "input": "while most of those located in the deep and marginal zones bordering the adjoining intact areas were remyelinated by oligodendrocytes.", "output": [ "finding" ] }, { "id": "task1163-44e627feaf834562bb47a0268439c568", "input": "In this study , we have exploited the structural information to identify the residues that are important for the catalytic activity of 2 0 - O MTase of VP4 and their influence on BTV replication.", "output": [ "purpose" ] }, { "id": "task1163-fac24c4be844460180c5cf5c433c6ad4", "input": "We hypothesized that highly immunodeficient NSG mice would support the survival and maturation of O. volvulus and alteration of the host microenvironment through the addition of various human cells and tissues would further enhance the level of parasite maturation.", "output": [ "purpose" ] }, { "id": "task1163-ab76c011e0734c0797761cfa57d64609", "input": "and association with respiratory symptoms.", "output": [ "purpose" ] }, { "id": "task1163-b04e837b7f574a4d9b59c75044a7242e", "input": "the risk factors , and outcome of MERS-CoV infection in the pediatric population.", "output": [ "purpose" ] }, { "id": "task1163-5a8f384cc37340539f6fe004df3265f5", "input": "However , the most important measure is not in a factor.", "output": [ "finding" ] }, { "id": "task1163-cd27210154824059ad91bcfb84fdcbb2", "input": "The problem is NP-hard , and the existing exact solutions are impractical for large instances.", "output": [ "background" ] }, { "id": "task1163-032b9cff393c4136a54d0d8120bb4b94", "input": "This paper summarizes the relevant considerations and the case studies conducted to establish the average angle of unobstructed sky ( q ) as a simple parameter to represent mean SMK for assessing view obstruction.", "output": [ "purpose" ] }, { "id": "task1163-b62f38ca3b2545b69e315bf858fef0dc", "input": "G-quadruplexes ( G4s ) have become one of the most exciting nucleic acid secondary structures.", "output": [ "background" ] }, { "id": "task1163-56c53922fdce41afb6d2f574feede150", "input": "was developed through inactivation with betapropiolactone and emulsification with MF59 TM adjuvant.", "output": [ "purpose" ] }, { "id": "task1163-aa21e0df67f84593b4cbc536e7a90323", "input": "To explore these mechanisms , we combined three biochemical techniques - Stable Isotope Labeling of Amino acid in Cell cultures ( SILAC ) ; biotin labeling of plasma membrane proteins followed by affinity purification ; and analysis of unique proteins binding to SNCA peptides on membrane arrays.", "output": [ "method" ] }, { "id": "task1163-beaf0fe87ac240be8b19ae0e4a581d2c", "input": "but not to the vaccination status , sex and transmission route.", "output": [ "finding" ] }, { "id": "task1163-c006be42a2f346ea944daea7484d1d46", "input": "This study provides drug repositioning candidates and targets for further in vitro and in vivo studies of SARS-CoV-2.", "output": [ "purpose" ] }, { "id": "task1163-7aa8176f382b4e69915353e0559a09cf", "input": "Materials and Methods : A comprehensive literature search involving mainly electronic and library sources of information were used to collate and synthesise published data.", "output": [ "method" ] }, { "id": "task1163-eb7311138adf45c4b1c7c405688e96eb", "input": "These epigenetic alterations are considered crucial elements in ( viral ) oncogenesis.", "output": [ "finding" ] }, { "id": "task1163-ac73e99fd5bf465994711e89a367436b", "input": "In this section , we review the performance of the signature across additional patient subgroups.", "output": [ "purpose" ] }, { "id": "task1163-e8e7c9f2913e404e985433c5f1e0469c", "input": "The global therapeutic monoclonal antibody market was valued at approximately US$ 115.2 billion in 2018 and is expected to generate revenue of $ 150 billion by the end of 2019 and $ 300 billion by 2025.", "output": [ "background" ] }, { "id": "task1163-6713e90cc1e74d10adffa0693d0b69b9", "input": "although GI illnesses are most common in the winter months.", "output": [ "background" ] }, { "id": "task1163-6089a8a53f704917bef4250f83da6abf", "input": "influential articles in critical care requires using multiple search terms and manuscript sources.", "output": [ "finding" ] }, { "id": "task1163-5ca6f2b047804e58b067d63c41dfbcf6", "input": "or to translate overlapping ORFs to increase coding capacity.", "output": [ "background" ] }, { "id": "task1163-b754d0aab8f24842b9b3b74357f13c26", "input": "Surveillance of livestock and the surrounding environment is a hallmark of early detection but is currently targeted to known risks.", "output": [ "background" ] }, { "id": "task1163-1318332741094ee6aa0f7e43bb12f49b", "input": "Sensitization to 1 or more of the common indoor allergens has been consistently associated with asthma among children and young adults ( odds ratios for asthma , 3-18 ).", "output": [ "background" ] }, { "id": "task1163-3579f09bff3446d6bdbccf2e4f276728", "input": "The cytotoxicity on HeLa and Jurkat tumor cell lines was also tested.", "output": [ "method" ] }, { "id": "task1163-afde512dcbff432096182ad33a557649", "input": "On this front , it is argued that the lack of standardization between smart city technology suppliers can lead and is leading to noncommunication between cities and data platforms.", "output": [ "finding" ] }, { "id": "task1163-bcdda23ef7ae41b08c28021b087ffb84", "input": "In this review we identify major bottlenecks that need to be resolved for WGS to routinely inform clinical intervention and discuss possible solutions.", "output": [ "purpose" ] }, { "id": "task1163-4d6319b278f44fb1a915de9057cfa945", "input": "fecal samples were collected per rectum from 15 healthy young-adult ( 2-12 years ) and 15 geriatric ( 20 years ) horses.", "output": [ "method" ] }, { "id": "task1163-b47e77c0feb44c1e9b8b8b4eb928dd96", "input": "This chapter will focus on mechanisms by which sumoylation both impacts human viruses and is used by viruses to promote viral infection and disease.", "output": [ "purpose" ] }, { "id": "task1163-9ed259ed3be74630a04dfb76c84e71c3", "input": "Dengue virus ( DENV ) constitutes a public health concern.", "output": [ "background" ] }, { "id": "task1163-dd1ff34bc3ec433b86be669fb6e1b879", "input": "which attenuates NLRP3 inflammasome activation during periods of metabolic stress.", "output": [ "finding" ] }, { "id": "task1163-238abfa6fc034dc28d8c6de3f240bde0", "input": "directly into the brains of immunized mice.", "output": [ "method" ] }, { "id": "task1163-1442bd26cc604f38b99298741658944b", "input": "We calculated correlations between linked individuals to investigate mixing patterns.", "output": [ "method" ] }, { "id": "task1163-d5a9b6117e7b4c0797750de00be0791f", "input": "This requires research into the virology of the disease in physiological models in conjunction with detailed phenotypic characterisation of asthma patients to identify targets amenable to therapeutic intervention.", "output": [ "background" ] }, { "id": "task1163-40cfb565edb541e980ffce9e25ad13ab", "input": "Vaccines that elicit a protective broadly neutralizing antibody ( bNAb ) response and monoclonal antibody therapies are critical for the treatment and prevention of viral infections.", "output": [ "background" ] }, { "id": "task1163-1eb397602dab4b2ca021eba74f175fe1", "input": "but many do not take preventive measures.", "output": [ "finding" ] }, { "id": "task1163-9711fbbe94c9498c99f98c0e7b35ac20", "input": "focusing on the impact of assortativity.", "output": [ "purpose" ] }, { "id": "task1163-784e55d2d1464f2b95dcc59c635f03e7", "input": "We demonstrated the mechanical and electrical implications of bacterial positioning at the solid-liquid interface of a TSM biosensor and presented a model of the TSM with bacteria attached operating as coupled oscillators.", "output": [ "method" ] }, { "id": "task1163-62adb95630164bc8a26c07a5598649b6", "input": "The present study aimed to investigate the role of CXCL9 in prostate cancer.", "output": [ "purpose" ] }, { "id": "task1163-168fe0cdfab0431fa0109dc4d4d93166", "input": "The outcome of viral infection depends on the interplay between host factors and the environment.", "output": [ "background" ] }, { "id": "task1163-a5b78b699df94a7b8be5db7bb2da40a5", "input": "nitric oxide , interleukin-1b and tumour necrosis factor-a levels using appropriate reagents and ELISA kits.", "output": [ "method" ] }, { "id": "task1163-4d8e9f2ac4a14ba081e55aa3355e2b89", "input": "The present study was performed to investigate the potential protective effect of myricitrin against hypoxia/reoxygenation ( H/R ) - induced H9c2 cardiomyocyte injury and its underlying mechanisms.", "output": [ "purpose" ] }, { "id": "task1163-76fd6c7cbc6348c280649108605bb0bf", "input": "Administration of recombinant feline interferon-v ( rFeIFN ) has been proposed for the prophylaxis of canine and feline parvovirosis.", "output": [ "background" ] }, { "id": "task1163-c16ba39f3b4d4eb8908ce37b3f2d9413", "input": "the size of 62 the host population is given by N h = S h + I h + R h.", "output": [ "method" ] }, { "id": "task1163-9c0108b0fbab4032abdf53afc9a6d6a6", "input": "while peak respiratory rate and peak rectal temperature appeared more than a week later than the peak shedding.", "output": [ "finding" ] }, { "id": "task1163-462008c145f84abea9c99d186bfb08fe", "input": "In this review , we summarize the current understanding of ZIKV biology and describe our efforts to rapidly develop a vaccine against ZIKV.", "output": [ "purpose" ] }, { "id": "task1163-bd55f44e6323437da97cbcd0ab60781a", "input": "China , the novel coronavirus ( 2019-nCoV ) infection has been quickly spreading out to other provinces and neighboring countries.", "output": [ "background" ] }, { "id": "task1163-d4b7c8238f1a4b8f932ff98d1b1654fc", "input": "and the proportion of subclinical infections.", "output": [ "method" ] }, { "id": "task1163-2262d66f7aee4eddabfe27ee7149d007", "input": "We investigate the properties of a simple discrete time stochastic epidemic model.", "output": [ "purpose" ] }, { "id": "task1163-7085e5d58424417880ab337f7c51fe11", "input": "Studies on rare aneurysm specimens reveal plasma cell infiltrates.", "output": [ "background" ] }, { "id": "task1163-c76affc5d86340bab02efeabd12ce9d4", "input": "peaked at week 7 and were maintained at a higher level for 4 weeks following immunization when compared with the negative control.", "output": [ "finding" ] }, { "id": "task1163-c6c6ab7acc034e5aad98f8cbb11f2867", "input": "These findings might help to illustrate the pathogenesis of persistent infection caused by BVDV.", "output": [ "finding" ] }, { "id": "task1163-af4dcd9404cc4628a5380340b85b5901", "input": "cytometric bead-based array ( CBA ) and real-time polymerase chain reaction ( RT-PCR ) ; the relevance of these methods of cytokine quantification was explored.", "output": [ "method" ] }, { "id": "task1163-ed862faba20b406aa7d17dac14e65411", "input": "and two were actually fitter in tests in two kinds of cells.", "output": [ "finding" ] }, { "id": "task1163-72b1b405275d443b9d4813cc0feff1d5", "input": "Mortality increased to 12 % ( 30/258 , 30 % increase ) when electronic vital records and a 30-day posthospitalization time frame were used.", "output": [ "finding" ] }, { "id": "task1163-cfb54cb5d7934606b16f473aa97d6b4c", "input": "and other 42 pharmacologically active compounds as inhibitors of M pro.", "output": [ "method" ] }, { "id": "task1163-57afdda5f6424ae5ab0acf0c19651464", "input": "were retrospectively analyzed in order to investigate whether these values had clinical significance for the prognosis of the patients.", "output": [ "method" ] }, { "id": "task1163-a6a4685939c246b590d84174a0695aa7", "input": "and varied from 0.4 to 0.7 mm in depth.", "output": [ "method" ] }, { "id": "task1163-d77415b4b9c04548beef28d169ab4765", "input": "In this research , we consider how a central policy-maker can induce a socially optimal vaccine coverage through the use of incentives to both consumers and the vaccine manufacturer.", "output": [ "purpose" ] }, { "id": "task1163-cc88aad19b854fc7af96e98ce408a10c", "input": "and three provided promising antiviral activities and acceptably low toxicities.", "output": [ "finding" ] }, { "id": "task1163-a85087e9abc7490ebd3d3531e5294752", "input": "We evaluated the usefulness of a serum Aspergillus PCR assay for the diagnosis and prognosis of invasive aspergillosis in a study involving 941 patients for a total of 5146 serum samples.", "output": [ "purpose" ] }, { "id": "task1163-684e77926a5d40e29d7497ace4942abe", "input": "The mechanism of demyelination is not apparent because there is no ultrastructural evidence of viral replication in the oligodendrocytes , the myelin producing cells.", "output": [ "background" ] }, { "id": "task1163-25ccace743a946f8befa884eab9cc4a9", "input": "lysosomal delivery , and proteolysis.", "output": [ "finding" ] }, { "id": "task1163-f8eca93e2af84c5192f6ea4e813cef9c", "input": "a trypanocidal drug , restored the development of CIA-associated clinical symptoms.", "output": [ "method" ] }, { "id": "task1163-9414eab9e53d4414a62f9fd8093ab481", "input": "Middle East respiratory syndrome coronavirus MERS Healthcare-associated outbreaks S U M M A R Y Middle East respiratory syndrome coronavirus ( MERS-CoV ) is capable of causing acute respiratory illness.", "output": [ "background" ] }, { "id": "task1163-b1806afda6084736960ee46651ad73df", "input": "determining the reasons for disease persistence as well for the onset of reinfection is also essential.", "output": [ "background" ] }, { "id": "task1163-21ed2f85207a427db4bc39b8d3f3aa84", "input": "and the antibodies assays presented lower positive rates ( IgM , 23.0 % , IgG , 53.8 % ).", "output": [ "finding" ] }, { "id": "task1163-e133e35829af4b8bb84717f876989e1d", "input": "conditions , SARIMA could reduce detection delay by 5-16 days.", "output": [ "finding" ] }, { "id": "task1163-0cd1b3e796a24ce3abc7ce67f1375bfd", "input": "A Lineweaver-Burk plot confirmed that EGCG and EGCG-G1 were competitive inhibitors of maltose substrate against HMA and inhibition kinetic constants ( K i ) calculated from a Dixon plot were 5.93 ± 0.26 and 7.88 ± 0.57 µM , respectively.", "output": [ "finding" ] }, { "id": "task1163-8267f36d963b49cba23162160fe612df", "input": "In mice , plasmacytoid dendritic cells ( pDC ) and natural killer ( NK ) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus ( MCMV ).", "output": [ "background" ] }, { "id": "task1163-e4ced88b55ed46ffababed62fa2cc23b", "input": "RNA viruses encode an RNA-dependent RNA polymerase ( RdRp ) that catalyzes the synthesis of their RNA ( s ).", "output": [ "background" ] }, { "id": "task1163-29b6b407e5d44d939329891ef96b3640", "input": "the presence of virus in blood and tissues and to test the hypothesis that seropositive calves are not infectious to naïve in-contact calves three weeks after BCoV infection.", "output": [ "purpose" ] }, { "id": "task1163-25cb54044ec14d229a910982c335276d", "input": "In these persons , whether B. pertussis is a primary or secondary pathogen or an innocent bystander is not clear.", "output": [ "background" ] }, { "id": "task1163-06a449fb99d34e528a7687f2c2f08568", "input": "which use them as clocks for time-sensitive processes.", "output": [ "background" ] }, { "id": "task1163-46fb5b9aff36497c93c7675751b090d9", "input": "geographic location , sample collection date and type and co-infection with other viral pathogens.", "output": [ "purpose" ] }, { "id": "task1163-90d4369e9c3f41ed86e8f786b56b0390", "input": "monocytes , and peripheral blood mononuclear cells and has high-binding avidity demonstrated by surface plasmon resonance.", "output": [ "background" ] }, { "id": "task1163-67cc1906803c4198a77bb8afae882442", "input": "monitor and evaluate large-scale development programs.", "output": [ "finding" ] }, { "id": "task1163-f89f85a61f6d4b0bbc60c32c4319ef7c", "input": "as well as epidemiologic studies examining the potential role of toilets in infectious disease outbreaks.", "output": [ "method" ] }, { "id": "task1163-2270a655e16a40d79244f5378752baaa", "input": "a viral 2 = Omethyltransferase ( 2 =O - MTase ) that encodes critical functions in immune modulation and infection.", "output": [ "purpose" ] }, { "id": "task1163-bba6ffd64f0a4a66b5adf10ba2f3a3d0", "input": "The plague is an infectious bacterial disease having a high fatality rate without treatment.", "output": [ "background" ] }, { "id": "task1163-833328c3bb9f41118e2c9fdfbf5f38ef", "input": "regional ( n = 9 ) and national ( n = 3 ) laboratories using molecular diagnostic methods.", "output": [ "method" ] }, { "id": "task1163-7a24c05e49b1457ba1deb62aaf492cd0", "input": "The solver for FFD-Markov-chain model was programmed in OpenFOAM , an open-source CFD toolbox.", "output": [ "method" ] }, { "id": "task1163-192280db759e47dc8cc7c771b00aa020", "input": "with the specific aim of evaluating the association between PI and health status of calves within 30 days of age under field conditions.", "output": [ "purpose" ] }, { "id": "task1163-2d7a83fcd4b14bd58be77b22feed35d3", "input": "chemokine receptors ( CCRs ) and death receptor ligands in SARS-CoV infected DCs.", "output": [ "purpose" ] }, { "id": "task1163-013afbd25dde43a792d00da21717a143", "input": "Jalview v2 and CLC Sequence Viewer v7 .0.2 were used for the initial sequence analysis for securing the conservancy from the sequences.", "output": [ "method" ] }, { "id": "task1163-52dee48d6452423c912c9814de370664", "input": "However , a large proportion of HAI are preventable through effective infection prevention and control ( IPC ) measures.", "output": [ "background" ] }, { "id": "task1163-ba3cc57af1674d879a27da191c97b411", "input": "The method of swabbing on moistened surfaces was used for sampling.", "output": [ "method" ] }, { "id": "task1163-6c2b727e7f834f029d30528099fb812b", "input": "Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities.", "output": [ "background" ] }, { "id": "task1163-6adaa49c9a504714835684991505de99", "input": "researchers are left to examine clinical signs and disease pathology.", "output": [ "background" ] }, { "id": "task1163-0b0dc112f2a7438c9edaa96da643ebee", "input": "Cats that survived the outbreak were vaccinated and re-sampled 1 month after the last rFeIFN administration.", "output": [ "method" ] }, { "id": "task1163-fea526b3c1c14460879a4457d131f708", "input": "Methods : Six-core-competency-based OSCE was used as examination of the clinical performance of 192 PGY 1 residents during their 3-month internal medicine training between 2007 January and 2009 December.", "output": [ "method" ] }, { "id": "task1163-af0cf64ae4b944cba18fa2bff95ed2b5", "input": "to demonstrate the manganese-dependent covalent binding of guanosine and uridine phosphates to a lysine/histidine residue.", "output": [ "method" ] }, { "id": "task1163-bc2d1a142df741229c619e2499996d89", "input": "In this study , NiV-G protein served as the target immunogen to activate NiV-specific cellular immune responses.", "output": [ "method" ] }, { "id": "task1163-1919c8211b0340aca3e9b4a9e27faac6", "input": "including Fusobacterium necrophorum , in patients with pharyngotonsillitis and in asymptomatic controls.", "output": [ "purpose" ] }, { "id": "task1163-55aa1fb040864df5ae4086e4a6a004ee", "input": "We examined whether this synergistic effect is involved in the evolution of different types of ischemic stroke.", "output": [ "purpose" ] }, { "id": "task1163-c7b354e4e9c748988da36d68031832e1", "input": "Decreased prothrombin time activity and increased partial thromboplastin time were observed at the 6 and 9 weeks after infection and decreased of factors VIII and V activities occurred from 4 to 6 weeks after infection.", "output": [ "finding" ] }, { "id": "task1163-60f53606f5db49148f77b3392d9c6a05", "input": "In this contribution , the classification of protein binding sites using the physicochemical properties exposed to their pockets is presented.", "output": [ "purpose" ] }, { "id": "task1163-48e313f7397a44a9b77fd0faaeaebc11", "input": "Thus , this study aimed to evaluate the effect of different isolation strategies on the prevention of secondary viral transmission and clinical outcomes among exposed HD patients.", "output": [ "purpose" ] }, { "id": "task1163-d464ac42793a4a14b945c057951fa47d", "input": "Fast and slow axonal transport of protein have been studied in the optic nerves of mice infected with Semliki Forest Virus ( SFV ) that causes patchy demyelination throughout the CNS.", "output": [ "background" ] }, { "id": "task1163-1bd0644f1afb4a098311200030405e6a", "input": "are the fastest growing field in clinical laboratory diagnostics.", "output": [ "background" ] }, { "id": "task1163-90aa6a6160e34580acf8cdf48749e438", "input": "In this review , we summarize the current knowledge on the expression of molecules involved in the cross-talk with T-cells in both microglial cells and DCs and discuss the potential contribution of each of these cell populations on the control of lymphocyte function within the CNS.", "output": [ "purpose" ] }, { "id": "task1163-e436edf5148944538ffa3b08fcf40b30", "input": "In the second experiment , live aMPV subtype B vaccine was used in place of NDV.", "output": [ "method" ] }, { "id": "task1163-1b626b640bf34c82bd13f685291b6d87", "input": "Original antigenic sin in 10-valent inactivated HRV-vaccinated mice.", "output": [ "method" ] }, { "id": "task1163-2cc9accd71a14d318b43c92f497ec2c9", "input": "sex workers , men who have sex with men , and plasma donors.", "output": [ "method" ] }, { "id": "task1163-45714b1fdf7b45b2a20005819778d607", "input": "The objective of the current work was to describe the clinical and epidemiological characteristics of A ( H7N9 ) patients in Guangzhou and explore possible reasons for the high fatality rate.", "output": [ "purpose" ] }, { "id": "task1163-379b627a2d704a3786574910b52c322c", "input": "particularly in outbreaks , it also has some limitations and can be associated with negative effects.", "output": [ "method" ] }, { "id": "task1163-bc6c9275d378494cafe335c1ba5bf37f", "input": "and up to date , corticosteroid is commonly administrated to severe patients with COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-3cd46313f8d04725986543cdfa6d458f", "input": "Here , we present a strategy for probe design based on protein sequences that is responsive to the unique problems posed in virus detection and discovery.", "output": [ "purpose" ] }, { "id": "task1163-b0e54aa13a474467bc92c75fe4e3d6a1", "input": "the nucleic acids contaminated in fetal bovine serum.", "output": [ "finding" ] }, { "id": "task1163-26de717dd20b4f28bfed605cfb7841ea", "input": "A study was performed to evaluate porcine torovirus ( PToV ) seroprevalence and infection in three multi-site farms from the North-eastern region of Spain.", "output": [ "purpose" ] }, { "id": "task1163-61fc38bab70943f3babeea0547dc5843", "input": "Phage display ; Fab ; antibody library ; IgM ; one-step cloning Building a high-quality phage-displayed antibody library requires a source of large number of well-diversified antibody genes.", "output": [ "method" ] }, { "id": "task1163-1e11dc02285e48279d965fce2cf12cd1", "input": "In this chapter we outline the methods by which we establish fully differentiated airway epithelium and its use for human coronavirus propagation.", "output": [ "purpose" ] }, { "id": "task1163-996ed299cd744dfbb0432256f0585064", "input": "In this report , further characterization of the two cleavage sites demonstrates that the N-terminal Q 2779 - S 2780 site is tolerant to mutations at the P1 position.", "output": [ "finding" ] }, { "id": "task1163-590e718b80a7481f9e55e31cc0af888c", "input": "and the similarity of its sweetness to sucrose.", "output": [ "background" ] }, { "id": "task1163-e67bafed545540da91cab1bd2eb2027f", "input": "Superimposition of the PLP2 model on the PLpro X-ray structure identifies binding site residues in PLP2 that contribute to the distinct substrate cleavage site specificities between the two proteases.", "output": [ "finding" ] }, { "id": "task1163-b1fb5e520bc7451bbf6a2704d7b33602", "input": "Adult and larval stages of beetles were collected from the litter of pigeon houses , and identified morphologically.", "output": [ "method" ] }, { "id": "task1163-220600096bdb4b0b9ffed3382d05ab15", "input": "despite claims made in the popular and scientific press.", "output": [ "finding" ] }, { "id": "task1163-d21aa654a961472ab3d828b074509c0f", "input": "the evaporator and the condenser subsequently.", "output": [ "method" ] }, { "id": "task1163-deefe0ed5ad749e28de7765de5055192", "input": "Potential health benefi ts attributed to bovine colostrum have increased manufacture and marketing of colostral Ig-based dietary supplements also for human use.", "output": [ "background" ] }, { "id": "task1163-9037d2eb2a464d268d80caa14fadf3d3", "input": "which has been recognized as a pandemic by the World Health Organization ( WHO ) on March 11 t h.", "output": [ "background" ] }, { "id": "task1163-02e11c547f5d4df59633ed576e2977ea", "input": "Both the tablet and liquid formulations will be included.", "output": [ "method" ] }, { "id": "task1163-c619b6fb324a45d6b96148fccf8cfd12", "input": "identify the M pro as an attractive 58 target for antiviral drug design 9.", "output": [ "background" ] }, { "id": "task1163-1181da0b6fc2417398c3c277acf1608e", "input": "as such , there is scope for intervention at the animal/insect/environmental reservoir.", "output": [ "finding" ] }, { "id": "task1163-3d504f6e8fc743cf80462fa1d30332af", "input": "The study of proteomics helps to better understand the mechanism of a disease.", "output": [ "purpose" ] }, { "id": "task1163-f66dd11f8757435984d1a3c00b6300f6", "input": "pathogen , and environmental factors in driving transmission heterogeneity across hosts and space.", "output": [ "purpose" ] }, { "id": "task1163-2a6a54f3642c41edb54c414908e36e33", "input": "The evolutionary relationship between 2019-nCoV and the other human respiratory illness-causing coronavirus is not closely related.", "output": [ "background" ] }, { "id": "task1163-19212a1c6d054b35afdaaf4cd063623e", "input": "Geckler 's classification of specimens was used.", "output": [ "method" ] }, { "id": "task1163-59ec96e89fc8414cbc218a9b6f04a38e", "input": "have not been thoroughly investigated.", "output": [ "background" ] }, { "id": "task1163-f9e8db4af5b7421b927b30f89bbdf18f", "input": "Indeed , the observation that amyloidogenic proteins adopt similar secondary structures along the pathway to fibril formation opens the way to an interesting investigation : the development of inhibitors that could be universal amyloid traps.", "output": [ "background" ] }, { "id": "task1163-e22e734da66c472e90f8228a008e92b1", "input": "In this study , we investigated the cross-protection of H5N1-M2e against lethal infection with the new H7N9 virus.", "output": [ "purpose" ] }, { "id": "task1163-f3e60fba7bc44d64867a750ccf53a541", "input": "the outbreak is expected to peak within two weeks ( since 23 January 2020 ) with a significant low peak value.", "output": [ "finding" ] }, { "id": "task1163-087ce3d8df484ca990068359c2fb8f97", "input": "Methods Patients with COVID-19 pneumonia ( confirmed by next-generation sequencing or RT-PCR ) who were admitted to one of two hospitals in Wuhan and who underwent serial chest CT scans were retrospectively enrolled.", "output": [ "method" ] }, { "id": "task1163-03e31947ce444c82b5f5f52811b83379", "input": "focusing our attention on the contribution of regulatory T cells and myeloid-derived suppressor cells to the lack of therapeutic success of DC-based cancer immunotherapy.", "output": [ "purpose" ] }, { "id": "task1163-a786c9447d4b45b79072cd4a3add1b00", "input": "One of the bovine partetraviruses detected in the present samples is phylogenetically distinct from previously reported bovine partetraviruses and likely represents a novel genotype.", "output": [ "finding" ] }, { "id": "task1163-f1baa625a22348e386f903af4460d83d", "input": "Our objective was to study the frequency of EBV in tonsils and adenoids and to define the correlation between EBV and adenoid hyperplasia.", "output": [ "purpose" ] }, { "id": "task1163-e9abc1bbdce447399f80c0bd5b96fa15", "input": "Later the Immune Epitope Database and Analysis Resource ( IEDB-AR ) was used for the identification of T-cell and B-cellepitopes associated with type I and II major histocompatibility complex molecules analysis.", "output": [ "method" ] }, { "id": "task1163-94ea25d5dbcd4e0dad0fb1c964d32a41", "input": "a condition known as heterozygous advantage.", "output": [ "purpose" ] }, { "id": "task1163-bf145ef00ab94a7d8b9143aca1784221", "input": "The proposed PSD/rAzu hybrid structure with a great capability of single mutation recognition and miRNA expression level profiling in cancer cells holds a very promising platform to be studied for further development of various kinds of nanoscale biosensors , bioelectronic devices.", "output": [ "finding" ] }, { "id": "task1163-acb2d95b5fa147709fd6f4a013265c4e", "input": "The RNA-Seq based transcriptome map identified 94 sRNAs in the H. somni genome of which 82 sRNAs were never predicted or reported in earlier studies.", "output": [ "finding" ] }, { "id": "task1163-b08baa14d2a9442eb62f07358e914d46", "input": "Here we report that Orthoquin also has antiviral properties.", "output": [ "purpose" ] }, { "id": "task1163-6f9ffd77da50423d933ebde03cb8c785", "input": "H , N and M , respectively.", "output": [ "finding" ] }, { "id": "task1163-ff13eb850a9e40788b80d3d9f36dc073", "input": "Specifically , both exhibited anti-HIV activity against viral replication at a low concentration and relatively low cytotoxicity at the effective concentration inhibiting viral growth by 50 %.", "output": [ "finding" ] }, { "id": "task1163-7ea8793447bb41c88184458fd55d1f3c", "input": "This review will discuss new insights as to how specific modifications at the 5 0 - end of viral RNA modulate host pathogen recognition responses to promote infection and disease.", "output": [ "purpose" ] }, { "id": "task1163-839ff80809434e629982ca7f0e67a21b", "input": "List and briefly discuss the Homeland Security Presidential Directives that apply to biosecurity and biodefense.", "output": [ "purpose" ] }, { "id": "task1163-d7a8df4ee95049788224f38cec839d5b", "input": "This review also examines progress toward the goal of achieving a comprehensive understanding of the chemical and physical basis for molecular recognition of viral surface proteins in order to build predictive molecular models that can be used for vaccine design.", "output": [ "purpose" ] }, { "id": "task1163-92a4c05c6b1343e19a4bc6c4ea8b0d19", "input": "Several antigens originating in cercariae and fewer in schistosomula were recognized by IgY with diverse sensitivity and specificity ; only a few seemed to be common to both stages.", "output": [ "finding" ] }, { "id": "task1163-2f79c1d3fa1d4ed4addf2d60c6f41d18", "input": "Chen et al. showed that the banaba water extract exhibited an insulin-like glucose transport inducing activity.", "output": [ "background" ] }, { "id": "task1163-222b56f3739e49c0b68ff8bcabd8fcff", "input": "Twenty-seven field samples that showed positive in PEDV detection were collected from different farms of Fujian province from 2010 to 2012.", "output": [ "method" ] }, { "id": "task1163-f51d1e38fc5643e594fc385654440e45", "input": "Twenty-five peptides ( Ten for B4 , six for B12 , two for B15 , and seven for B19 ) were predicted to be potential T cell epitopes in chicken.", "output": [ "method" ] }, { "id": "task1163-4e32e08b20594ae283f5c0c1731f5cf7", "input": "Methods : IBV strain GD was isolated from southern China in 2013 and the complete genome sequencing and phylogenetic analysis were performed.", "output": [ "method" ] }, { "id": "task1163-c6e7702386b74da1b5b0b6e37e803e58", "input": "We used the model to quantify the potential effectiveness of contact tracing and isolation of cases at controlling a 2019 nCoV-like pathogen.", "output": [ "method" ] }, { "id": "task1163-b81b588a334e4b578d2cba3c683bf8f9", "input": "This paper focuses on predicting the protein structure based on 3D images of the proteins captured through cryogenic electron microscopes ( cryo-EM ).", "output": [ "purpose" ] }, { "id": "task1163-7133fdc03b914ea187abb36514c1f215", "input": "CC1 facilitated binding of soluble CEACAM1 to CEACAM1 expressing cells.", "output": [ "finding" ] }, { "id": "task1163-ed9625d556a34395b12e424855acae65", "input": "Here , we provide an update of recent advances in the intracellular delivery mechanisms that could help drugs reach their target more efficiently.", "output": [ "purpose" ] }, { "id": "task1163-a6688df587c44bf99c4ce2ed393a82da", "input": "The candidates selected from docking studies were subsequently tested using biological assays to assess anti-HIV activities.", "output": [ "method" ] }, { "id": "task1163-416d8d3595c548edae7b4a8195bca8a3", "input": "1 1 + αI 2 represent the psychological effect from the behavioral 44 changes of susceptible population when the number of infected populations increases.", "output": [ "method" ] }, { "id": "task1163-bf0255bf4332462ab42fa02c8b1faffc", "input": "The role of the N terminus of helix α7-unique for CNPase in the 2H family-during the reaction indicates that 2H phosphoesterases differ in their respective reaction mechanisms despite the conserved catalytic residues.", "output": [ "finding" ] }, { "id": "task1163-e80c163798eb40678b94e7590a3a76a8", "input": "We postulated that NANOG is involved in the pathogenesis of gestational trophoblastic disease.", "output": [ "purpose" ] }, { "id": "task1163-eac07e1695bd456b8fbf7408e01e95fa", "input": "highlighting the impact of the control measures on the progression of the epidemic.", "output": [ "finding" ] }, { "id": "task1163-bc31faa61c3d4279ba1feffd9a481283", "input": "A comparative assessment of four serological methods used in the detection and measurement of anti-parasite antibodies in the serum of the amphibian , Bufo viridis.", "output": [ "background" ] }, { "id": "task1163-bbb4e9c4d3214e669aa5047c9fd8b902", "input": "Mice of 11 weeks of age weighing between 26 and 34 g were used.", "output": [ "method" ] }, { "id": "task1163-bb0ddcf406fb4411816460946f840a11", "input": "We report here the complete genome sequence of the porcine epidemic diarrhea virus strain CH/ZMDZY/11 isolated from central China.", "output": [ "background" ] }, { "id": "task1163-abfc764c969347fca63ec576f171f998", "input": "No lymphadenopathy was identified.", "output": [ "finding" ] }, { "id": "task1163-06c94eafa2f24d0aad0a0f68ce0931af", "input": "Model formulation 57 We consider two population groups as host and vector population.", "output": [ "method" ] }, { "id": "task1163-0a68018d40e2451da77fdcd12b7fd66e", "input": "Archaeal DnaG contains N-and C-terminal domains ( NTD and CTD ) of unknown function flanking a TOPRIM domain.", "output": [ "background" ] }, { "id": "task1163-28800243b0a24ac6b337935c5e65f56c", "input": "we assembled a panel of hepatic and non-hepatic cell lines and assessed their ability to support HCV infection.", "output": [ "method" ] }, { "id": "task1163-d3dacc563f844300b51f5a0f2368fb97", "input": "technical requirements and cost , are likely to be as important for making a decision about which of these assays to use given their comparative performance.", "output": [ "finding" ] }, { "id": "task1163-cee33efd59294135aace0e0fe71aa9f0", "input": "The purpose of this chapter is to review and discuss the interpretation and relevance of results produced by these advanced molecular techniques.", "output": [ "purpose" ] }, { "id": "task1163-b1da8d4872a5453a9cc2b273d1cba7e8", "input": "The effective number of codons ( ENC ) analysis showed the CUB was weak in these four species and the four subgenomes of the two tetraploids.", "output": [ "finding" ] }, { "id": "task1163-d3e88241aa93435ebde80c2a493c3315", "input": "and the oxyanion loop near the S1 substrate-binding subsite in domain II.", "output": [ "finding" ] }, { "id": "task1163-8d2251a7a4164be6bd6ee4ce1f266b38", "input": "genetically engineered iPSC overexpressing nCoVN ( iPSC-nCoVN ) were generated by lentiviral expression systems.", "output": [ "method" ] }, { "id": "task1163-00638974871648a3b7f0f36f14bc13b5", "input": "and binding was probed using 0.5 µg/ml of biotinylated HA proteins A/Perth/2009 H3N2 and A/California/7 / 2009 H1N1 followed by the addition of streptavidin-HRP ( 1:5000 ).", "output": [ "method" ] }, { "id": "task1163-374d046c4cbb459abeb9fb21d29040be", "input": "attempts were made to determine whether levels of this cytokine were modified in sera of infected mice.", "output": [ "finding" ] }, { "id": "task1163-6640eb8565b14d33b21841d157b1828d", "input": "The mammalian reoviruses also display strain-specifi c differences in their modulation of the IFN response.", "output": [ "background" ] }, { "id": "task1163-1a1d354f710e4ca6a6ab1604fb7fe557", "input": "Objectives : To synthesize new transitional metal complexes derived from 3-aryl-azo-4-hydroxy coumarin analogues and to evaluate their antimicrobial activities.", "output": [ "purpose" ] }, { "id": "task1163-692bbe11c8e94bf99a3b3d99a855f26d", "input": "and whether cognitive recovery was correlated with structural plasticity.", "output": [ "purpose" ] }, { "id": "task1163-6bb70a6cc9af416380a4390cd1c80a74", "input": "regulate antiviral immune responses , determine viral clearance , and spread.", "output": [ "background" ] }, { "id": "task1163-221dbfd6775d4f8b9d7efe4b2b2296ad", "input": "Known human coronaviruses are believed to have originated in animals and made use of intermediate hosts for transmission to humans.", "output": [ "background" ] }, { "id": "task1163-d098eac460a04008bf7c2bd7fd08515e", "input": "leading to ~ 100,000 deaths globally each year and hundreds of millions of dollars in healthcare costs.", "output": [ "background" ] }, { "id": "task1163-f197cdd263394165bb75b8f18534bf9d", "input": "We developed a simple agglutination test for the detection of porcine rotavirus in stools from pigs with diarrhea.", "output": [ "purpose" ] }, { "id": "task1163-a187964e181d42e28198c95c060c8174", "input": "although no clear guidelines exist for its use for this purpose.", "output": [ "background" ] }, { "id": "task1163-acea203f9c504b8ab80e40c6166091de", "input": "and has been implicated in psoriasis pathogenesis.", "output": [ "background" ] }, { "id": "task1163-322dc212a4ae496ca1ee40963ef81aef", "input": "ANDV and SNV , and then discussed the existing knowledge on vaccines and therapeutics against these diseases.", "output": [ "purpose" ] }, { "id": "task1163-0a1dac9039ea4f3ea862b64b5e583655", "input": "Conclusion : The use of electronic vital records increased SARI-associated mortality estimates by 30 %.", "output": [ "finding" ] }, { "id": "task1163-5aa98114e6364cb99f21addbfc1c0a16", "input": "we used a minor alloantigen-mismatched murine orthotopic single lung transplant model.", "output": [ "method" ] }, { "id": "task1163-ad52d703bd8948aa9ad70aa7eec3a186", "input": "In this study , we explored the possibility that NS1 suppresses RIG-I-mediated antiviral signaling by targeting TRIM25.", "output": [ "purpose" ] }, { "id": "task1163-c600c0e6700b4dbeb14c793a68badc17", "input": "and in vivo in experimentally infected neonatal C57BL/6 mice.", "output": [ "method" ] }, { "id": "task1163-098d432cfc5b4fb6b6b963a885fa89de", "input": "In this report , we document the production of milligram quantities of homogeneous IFITM3 and key post-translationally modified variants by total chemical synthesis by using aketoacid-hydroxylamine ( KAHA ) ligation.", "output": [ "purpose" ] }, { "id": "task1163-0f98cf3f95a54557b49290dda8d88082", "input": "We describe the occurrence of an outbreak among HCWs and attempt to characterize at-risk exposures to improve future infection control interventions.", "output": [ "background" ] }, { "id": "task1163-9981d9ad470446ec8214503be88afbcd", "input": "Live attenuated viruses have generally proven to be the most effective vaccines against viral infections.", "output": [ "background" ] }, { "id": "task1163-8688ef380a6d471d91c94897fef07271", "input": "sample collection , and laboratory diagnosis were conducted to determine the cause of the outbreak.", "output": [ "method" ] }, { "id": "task1163-203842848317429d941d12054c56fd59", "input": "Conclusion : JNK1/2 and p38 MAPK signaling pathways are beneficial to EV71 infection and positively regulate secretions of inflammatory cytokines in iDCs.", "output": [ "finding" ] }, { "id": "task1163-f9489af0c4ae4668bae126082ddbf425", "input": "visited local markets , where six of them consumed fruits.", "output": [ "finding" ] }, { "id": "task1163-58a74011555d4fe996d8ed1e9e929af8", "input": "a virus strain handled at two FMD laboratories located on a single site at Pirbright in Surrey.", "output": [ "purpose" ] }, { "id": "task1163-9f70d698763d491ca53d53e8f9c49844", "input": "based on evidence about the stress associated with working in healthcare during the SARS outbreak.", "output": [ "background" ] }, { "id": "task1163-05c4e3149eb74a28a24a42aaeae74c4c", "input": "the Anyplex II RV16 and the xTAG respiratory virus panels.", "output": [ "purpose" ] }, { "id": "task1163-999e4679cd884056863a79a3b640a7af", "input": "All the top 5 % ( n = 8 ) most reactive human samples tested by ELISA were HCoV-NL63 positive by immunofluorescence testing.", "output": [ "finding" ] }, { "id": "task1163-273356d138a94df8ba8348d5a2c39ab1", "input": "and alternative mechanisms should be considered.", "output": [ "finding" ] }, { "id": "task1163-3d61a8b37b424c61b0c96094b92b4723", "input": "Our understanding of how the microbiota impacts virus infection is largely limited to the bacterial component of the microbiota.", "output": [ "background" ] }, { "id": "task1163-495df8e96c634b5ca3677edb8dd1c4cc", "input": "viral culture ( VC ) and cytodiagnosis ( Tzanck smear ).", "output": [ "method" ] }, { "id": "task1163-e5318860588c4d4d83f90447d99c536a", "input": "probably involving increased formation of beta amyloid ( Aβ ) and of AD-like tau ( P-tau ) - changes found to occur in HSV1-infected cell cultures.", "output": [ "background" ] }, { "id": "task1163-e72684f341884f778f5896d3f86c75f8", "input": "while in the QX-like strains they contained 59 amino acids in length.", "output": [ "finding" ] }, { "id": "task1163-6954bd0b24b7494790bf7e383d882d4c", "input": "affinity , and off-rate of the Mycobacterium tuberculosis-associated antigen TB10 .4 and identified only three TB10 .4 peptides with considerable binding to HLA-A * 3001.", "output": [ "method" ] }, { "id": "task1163-2c491e3de9e543c58e6b11a054768ede", "input": "we summarize the anticancer properties of NM in existing studies both in vitro and in vivo.", "output": [ "purpose" ] }, { "id": "task1163-8a0f234bf5cb4ff988fb7a8fa507e71b", "input": "followed by stable attachment of viral glycoproteins to cell surface receptors and fusion of the viral envelope to the plasma membrane or internal membranes ( 2 ).", "output": [ "background" ] }, { "id": "task1163-7b0bb6b564d14fab858798e10d6cfff2", "input": "have highlighted the importance of infection control.", "output": [ "background" ] }, { "id": "task1163-6e3bce31ee254994bec8dd11f6fe933e", "input": "Here , we describe fine mapping of its epitope by using several approaches.", "output": [ "purpose" ] }, { "id": "task1163-9a51cf8dee5e4b64b1aa28aca38824d5", "input": "The results show that PostPFree provides a better estimate of herd-level BTM status for both BRSV and BCV than what can be achieved by relying solely on the previous test-result.", "output": [ "finding" ] }, { "id": "task1163-8df3bcb5332745849e16a92bd2cfb78e", "input": "The average diameter of the silver colloids was approximately 10 nm.", "output": [ "method" ] }, { "id": "task1163-6f0276536535493fa8bad3ba1d681852", "input": "Virus infection is a complex biological phenomenon for which in vitro experiments provide a uniquely concise view where data is often obtained from a single population of cells , under controlled environmental conditions.", "output": [ "background" ] }, { "id": "task1163-975827e1977a412f84f7060d5ddabd88", "input": "medical costs , and mortality.", "output": [ "method" ] }, { "id": "task1163-885145e4b1994fb484304c779543c30e", "input": "This review summarizes the progress in new approaches in parasite diagnosis and discusses some of the merits and disadvantages of these tests.", "output": [ "purpose" ] }, { "id": "task1163-521e62ea2b6746128d4425184ad52a2a", "input": "our objective was to identify tools available for studying immune function in spotted hyenas and use these tools to document the hyena antibody response to immunization.", "output": [ "purpose" ] }, { "id": "task1163-7622c5046d4f4a82b127e2a32a386e4e", "input": "then assigned to eight treatments : four dietary treatments each evaluated across two group sizes.", "output": [ "method" ] }, { "id": "task1163-dbffea15e9e84631a82f3eccda519a76", "input": "Our primary measures are the prevalence of resistance of specific bacteria to specific antibiotics.", "output": [ "method" ] }, { "id": "task1163-636c0c95ad0044c692d6b3f01152383f", "input": "Recombination serves as a repair system as well as a means of changing the genetic structure of the virus.", "output": [ "background" ] }, { "id": "task1163-95848362545f428e8ed88e86e31fa0db", "input": "Background : Timely identification of respiratory virus infection is essential to mitigate inappropriate antibiotic use and to implement appropriate treatment and/or infection control procedures.", "output": [ "background" ] }, { "id": "task1163-8bab744d2bf445b8bd1b03b265595bc1", "input": "this investigation uses a validated computational fluid dynamics ( CFD ) program to design a new under-aisle air distribution system for wide-body aircraft cabins.", "output": [ "purpose" ] }, { "id": "task1163-46ef217bfe51427b9b751b6caaba84f1", "input": "which is higher than the incidence rates reported so far from India.", "output": [ "method" ] }, { "id": "task1163-ef53dc5e922744c5a68381395f21b2dc", "input": "which are known to be cross-reactive in serologic assays ; as well as Mycoplasma pneumoniae.", "output": [ "method" ] }, { "id": "task1163-156a1d25d4b7463ba7df1fe0f509d509", "input": "and its effect on cell viability was also studied.", "output": [ "method" ] }, { "id": "task1163-a3537c403174476493d41a6d7ac98e6f", "input": "Subsequent analysis was performed using R statistical software version 3.0.2 ( 3 ).", "output": [ "method" ] }, { "id": "task1163-6de95b7eae18401cac2e215a7aced38f", "input": "This review focuses on assembled peptide materials that actively participate in the biological processes important to cancer and transmittable diseases to exert an anticipated functional outcome.", "output": [ "purpose" ] }, { "id": "task1163-a728956bb35740c895c9a97417a9b002", "input": "These data provide additional insight into the difference between the virulent and avirulent strains of NDV.", "output": [ "finding" ] }, { "id": "task1163-1a524db1c62b4717be61781ead73e422", "input": "We describe a gap analysis done in the United Kingdom to assess IHR compliance of its overseas territories.", "output": [ "method" ] }, { "id": "task1163-42216eed6ba643a9914e9c586f0cd702", "input": "animal and food exposures to MERS-CoV.", "output": [ "method" ] }, { "id": "task1163-7574585c3e394c78aeb4e1a6ed215aaa", "input": "This study sought to identify and quantify possible drivers for the MERS-CoV emergence and spillover to humans.", "output": [ "purpose" ] }, { "id": "task1163-51523c5f2c9944d38a610a6213df1ed1", "input": "Pigs were the most frequently studied livestock and the virus diversity found in samples from poultry was the highest.", "output": [ "finding" ] }, { "id": "task1163-02c3c70c7765411bbe5dec79a36ea5da", "input": "Onset of symptoms for severe acute respiratory syndrome by number of shifts worked ( dashed lines represent 95 % confidence limits ).", "output": [ "background" ] }, { "id": "task1163-81118ed1bd5d4c6995074c0261a6969a", "input": "Here we have extended this approach to RNA by proposing potential functions for a rigorously conserved set of RNA tertiary structural interactions that occur within the SARS RNA genome itself.", "output": [ "purpose" ] }, { "id": "task1163-db5918e82bee453ebbf8e0d7be3e4074", "input": "While , the sensitivity of antibodies assays overtook that of RNA test since day 8 after onset ( IgM , 50.0 % ; IgG , 87.5 % ).", "output": [ "finding" ] }, { "id": "task1163-d5ba67ba4b484f48bf9edf6c62e5b042", "input": "reproduced the 180 ° ϕ-ψ dihedral rotation back to the open loop state.", "output": [ "background" ] }, { "id": "task1163-ab4bb1222e4348388ce07eb5549ded7d", "input": "Objectives : The outbreak of Middle Eastern respiratory syndrome coronavirus ( MERS-CoV ) was one of the major events in South Korea in 2015.", "output": [ "purpose" ] }, { "id": "task1163-1093be80701b47ca9912cbf3df799cfe", "input": "Results : AED fall-related attendance rate increased significantly with an annual percentage change of 4.45 ( 95 % CI 3.43 to 5.47 % , p < 0.0001 ).", "output": [ "finding" ] }, { "id": "task1163-3fa15c794c0740fc9968500f9fc0419f", "input": "Background : Coronavirus membrane ( M ) proteins are capable of interacting with nucleocapsid ( N ) and envelope ( E ) proteins.", "output": [ "background" ] }, { "id": "task1163-152591a1ebd444739c1d9cebb96e7da8", "input": "might be beneficial for the host during certain circumstances.", "output": [ "finding" ] }, { "id": "task1163-616659f8b0084d8183e31eca4f87953c", "input": "and our objective was to evaluate their status by analyzing polymorphisms and tissue expression.", "output": [ "purpose" ] }, { "id": "task1163-822f4cc9e1d24300a6247457baa6bb9a", "input": "We identified two additional de novo heterozygous missense variations of OAS1 in two unrelated simplex individuals also manifesting infantile-onset PAP with hypogammaglobulinemia.", "output": [ "finding" ] }, { "id": "task1163-7b0ec6004a2d47aea9a622e1fabbeb87", "input": "is a potential PET radiotracer for noninvasive imaging of apoptosis.", "output": [ "background" ] }, { "id": "task1163-178cd188725841078941cd36758670c3", "input": "2020 and explain in terms of power law exponent.", "output": [ "method" ] }, { "id": "task1163-322993f5254d4932b2c1d946f3087f03", "input": "and with this value found strong evidence to reject the null hypothesis that proximity was unimportant ( p < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-9153b1ed5cfd4b329a18d7bc50e4ff8a", "input": "Serum samples were analysed for antibodies to Epstein-Barr virus.", "output": [ "method" ] }, { "id": "task1163-e165c76557a244d5a36c1ed7ed1a0efc", "input": "we estimated case and infection fatality ratios ( CFR , IFR ) for COVID-19 on the Diamond Princess ship as 2.3 % ( 0.75 % -5.3 % ) and 1.2 % ( 0.38-2.7 % ).", "output": [ "finding" ] }, { "id": "task1163-0279bcf018ba4caabca62eea1e0d213e", "input": "a process resembling similarityassisted copy-choice RNA recombination.", "output": [ "background" ] }, { "id": "task1163-70c117c74d4940689932a4a397c92e7f", "input": "We used experimental evolution and a murine infection model to show that RNA virus mutation rates may actually be too high and are not necessarily adaptive.", "output": [ "method" ] }, { "id": "task1163-1fbdedd68b114c75b81b877bf21ba26f", "input": "The world was shocked in early 2003 when a pandemic of severe acute respiratory syndrome ( SARS ) was imminent.", "output": [ "background" ] }, { "id": "task1163-8a544e97ba0046489536255c19986ef2", "input": "Biochemical analysis established that 68K '' '' was not modified by N-linked glycosylation.", "output": [ "finding" ] }, { "id": "task1163-ab5bd669fe4c4b30ac4af77d05b9d17e", "input": "despite CT being widely used , clinically.", "output": [ "background" ] }, { "id": "task1163-faedbdac20944b96a1924cecaa8bf34d", "input": "its dynamics and associated management practices.", "output": [ "background" ] }, { "id": "task1163-ba66614e8d0c424fa70d3a3b687a50a1", "input": "and the amounts of virus from the onset of diarrhea were measured.", "output": [ "background" ] }, { "id": "task1163-1e210018db694a75b54c34e498499ccd", "input": "This disease has been responsible for significant economic losses in domestic and wild waterfowl as a result of mortality , and decreased egg production.", "output": [ "background" ] }, { "id": "task1163-04f3297fb4a44bb6aaf7d4a82b2c96ab", "input": "Qualitative data were collected through interviews with 29 frontline health service providers from the selected district and key informants of the IDSR system implementation and administration at district and national levels.", "output": [ "method" ] }, { "id": "task1163-e8ece15a70fa40fc9e320053bca82c53", "input": "During 2010-2013 , we screened 119 samples for RVC by an RVC VP6 gene-specific RT-PCR.", "output": [ "method" ] }, { "id": "task1163-ae506e83be1f491ebc8746db67fd44d1", "input": "One month later , all calves were reweighed.", "output": [ "method" ] }, { "id": "task1163-3718d8331c31437d895e00aa3f5c7d65", "input": "the majority of scenarios with an R0 of 1.5 were controllable with under 50 % of contacts successfully traced.", "output": [ "finding" ] }, { "id": "task1163-b318a7948ead4d47a889a8b63c4deade", "input": "Barriers and Mitigation tool , and Hexagon framework were used to review the existing monitoring system and develop a quality improvement data collection tool that considered the context of care delivery.", "output": [ "method" ] }, { "id": "task1163-8646305cdace47d79a9f822be31cccca", "input": "Also we acquire the results of similarity of 10 stock indices in three areas ; it means the method can distinguish different areas ' markets from the phylogenetic trees.", "output": [ "finding" ] }, { "id": "task1163-003956ff00bd4c6aa417e3a65e2c68a7", "input": "In this review we discussed recent advances toward clarifying the cross-talking between autophagy and viral infection in mammalian cells.", "output": [ "purpose" ] }, { "id": "task1163-ceb1090829f94886bda95d6ac5b8bf1e", "input": "which is essential for the viability and pathogenic virulence of the plague-causing Yersinia sp. bacteria.", "output": [ "background" ] }, { "id": "task1163-5e1e4d08b6c34fb2af1ea94cae6d59f9", "input": "We found increased Egr-1 protein expression in Tat-expressing human astrocytoma cells and mouse primary astrocytes.", "output": [ "finding" ] }, { "id": "task1163-90b5746775a04396a4f5c8753015d9ec", "input": "Norwalk virus , and HIV-1.", "output": [ "finding" ] }, { "id": "task1163-2df34870545e4c2eae583f8172ef6905", "input": "A few perspective directions of thread-based microfluidics in its development are also discussed.", "output": [ "method" ] }, { "id": "task1163-9e064790290545049b43a74211cde15e", "input": "In this study , we aimed to determine the effects of endogenous apelin on Ang II-induced pathology in the heart.", "output": [ "purpose" ] }, { "id": "task1163-31e0b98bf18d435f9fc2bba39c0eddb9", "input": "A neural network was trained to recognise the cleavage sites in the genomes obtaining a sensitivity of 87.0 % and a specificity of 99.0 %.", "output": [ "method" ] }, { "id": "task1163-1a03973009634b0395393b1a80df230f", "input": "The viral infected cells exhibit a complicated cross-talking between autophagy and virus.", "output": [ "background" ] }, { "id": "task1163-a8415dd47bd24d06a28cd8a15089aa77", "input": "had a neutralization index ( NI ) of greater than 4.4 and efficacy of 90 % when inoculated birds were challenged with a field IBV strain.", "output": [ "finding" ] }, { "id": "task1163-a806d70ca7574a7b816aa089325a8ac4", "input": "The usefulness of sequences that direct internal initiation was extended by using EMCV UTR s to express two and three ORFs from polycistronic mRNAs.", "output": [ "finding" ] }, { "id": "task1163-7ce67341ff0f431bb16101989e54d3d8", "input": "and greater body weight gain and structural growth during the preweaning period ; these effects did not persist in the postweaning period.", "output": [ "finding" ] }, { "id": "task1163-ce6d2c023d7749a7bdb79e4048c8d941", "input": "The purpose of this review is to examine the evidence that supports a role for peripheral infection in modulating the natural history of this disease.", "output": [ "purpose" ] }, { "id": "task1163-6050dd06d25e493eb447ab8e38bad795", "input": "the demonstration that individual extracellular cysteines contribute to APN expression and function appears to be of particular importance.", "output": [ "finding" ] }, { "id": "task1163-88596021ea9e4ffab6a61870fbfa0192", "input": "House flies detected carrying C. anatis using the diagnostic 374 bp amplicons represented the first record of this protozoan in house flies.", "output": [ "finding" ] }, { "id": "task1163-3490c2a91a5c424eb5f7fb4575852681", "input": "were exposed to coughing patients when visiting a hospital in Medina.", "output": [ "finding" ] }, { "id": "task1163-fae4f8adfebf47c98cc53d771ec33b42", "input": "airway inflammation , and FEV1 decline in patients with chronic obstructive pulmonary disease.", "output": [ "background" ] }, { "id": "task1163-a48f439f953a444b8c32a3e647f83b38", "input": "This recommendation goes well beyond the provision of adequate training and counseling.", "output": [ "finding" ] }, { "id": "task1163-f9106abb99754d65881b1ae848da4040", "input": "and availability of analytespecific reagents.", "output": [ "purpose" ] }, { "id": "task1163-d7f35a831f60480ab0228d9bd71aa29f", "input": "and serially diluted antibodies were incubated for 1 hr at room temperature.", "output": [ "method" ] }, { "id": "task1163-b137c64a7b1f494fb696ded36a648e17", "input": "as these myths can markedly in fl uence the interpretation and relevance of these results.", "output": [ "purpose" ] }, { "id": "task1163-5c678e3f42b84493a2042bf1bedde8ab", "input": "using Cy5-and FAM-labeled TaqMan-probes based on sequences from the TGEV and PEDV 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"finding" ] }, { "id": "task1163-df93b9ded2104c58aa2a07cf1b1a8f58", "input": "Our results provide evidence that patients occupying the same bay as patients with symptomatic norovirus infection are at an increased risk of becoming infected by these patients compared with patients elsewhere in the same ward.", "output": [ "finding" ] }, { "id": "task1163-3a6a02ceca48476c8eed1197495fe78a", "input": "Yet , its application is still in its infancy for monitoring and outbreak investigations of foods.", "output": [ "background" ] }, { "id": "task1163-20f4f58f01df4346b9c8ee2b442d442a", "input": "It presents a blueprint for a new schoolwide global health program at Mount Sinai School of Medicine.", "output": [ "purpose" ] }, { "id": "task1163-58155aac3dc64943be73a5cee07ea46a", "input": "It traces the development of global health programs in academic health centers in the United States.", "output": [ "purpose" ] }, { "id": "task1163-e59ceacfbfde4f8182cbb3845d07fa63", "input": "A subset of calves 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"task1163-b8ee4d99b8254cd9920cd80542ce99b6", "input": "The recombinant DNA and nanotechnology did not change the basic scientifi c strategy : live and non-live vaccines.", "output": [ "background" ] }, { "id": "task1163-70e49a5aa35540dcbde7d685ffa8359b", "input": "which is the ability to cooperate in coordinating key resources by going above and beyond for the community and minimizing operational confusion ( 16 ).", "output": [ "background" ] }, { "id": "task1163-c4a878a49e294155957fa1b7de7ab990", "input": "complement-fixation test ( CFT ) and enzyme-linked immunosorbent assay ( ELISA ).", "output": [ "background" ] }, { "id": "task1163-27b730f1742a440f9e67f043915a4c17", "input": "We studied the course of demyelination and subsequent remyelination of nerve fibers after heat injury in the dorsal funiculus of the rat spinal cord.", "output": [ "purpose" ] }, { "id": "task1163-6d02840ba86247b59446941f986138ab", "input": "Consequently , treatment with heparin devoid of anticoagulant 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"task1163-dec4b2e0c08f4f4987466ffc36656a7f", "input": "as well as highlighting the value of CF organisations and disease registries.", "output": [ "purpose" ] }, { "id": "task1163-9a6083cbbc834bff86accad96c970b39", "input": "and managers of the response team.", "output": [ "method" ] }, { "id": "task1163-3944c93fca5f4a8f95af70a7f50c2cf9", "input": "cord blood , and neonatal throat swab samples.", "output": [ "method" ] }, { "id": "task1163-cd50ef655f334d1794c85de6ffc1c912", "input": "Repeated assessments of infection control and monitoring of corrective measures contribute to changing the course of an outbreak.", "output": [ "finding" ] }, { "id": "task1163-31fa5eb6b7f944478166bf3b2108bf2d", "input": "where ~ 14 percent of Env was associated with Gag during productive infection.", "output": [ "finding" ] }, { "id": "task1163-b429a48456e243d5927a7d142588bf9b", "input": "The study site was divided into four areas based on the major roads.", "output": [ "method" ] }, { "id": "task1163-e84049cee83846538758158e9dc3cf28", "input": "Virus-like particles ( VLPs ) can be rapidly developed from influenza virus genetic sequences in order to supply vaccine after the onset of a pandemic.", "output": [ "background" ] }, { "id": "task1163-35708efee4994dae869e5e5d00e44a78", "input": "Purpose : The study aimed to examine query strategies that would provide an exhaustive search method to retrieve the most referenced articles within specific categories of critical care.", "output": [ "purpose" ] }, { "id": "task1163-2d981e1fe6df446695d352919bb5f354", "input": "and body weight were measured at birth and weaning.", "output": [ "method" ] }, { "id": "task1163-0dc0096f4d434c76ae750e604db08938", "input": "the performance of these materials as Solid Phase Extraction ( SPE ) sorbents was investigated.", "output": [ "method" ] }, { "id": "task1163-55b4ea59c9604b738add46b413296644", "input": "these new technologies paved the way for the parallel determination of multiple 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for SARS prevention by the World Health Organization ( WHO ).", "output": [ "background" ] }, { "id": "task1163-ca8cfbd55b4a41aea67fefbd88a5d68e", "input": "Undetectable nAb were assigned LOD/2.", "output": [ "method" ] }, { "id": "task1163-5122c32ba30444a99482d7bce9b991fa", "input": "The study enrolled 111 patients ( aged 3-23 months , 79 % hospitalized , 76 % with RV infection ) with the first wheezing episode.", "output": [ "method" ] }, { "id": "task1163-da1cdbdfc43a4d2da0659b9724243313", "input": "which yields large numbers of quiescent macrophages after 14 days of culture.", "output": [ "purpose" ] }, { "id": "task1163-218cbc0858bf42c181a0c1f85198dbdc", "input": "In the present study we investigated the entry of coronaviruses ( CoVs ).", "output": [ "purpose" ] }, { "id": "task1163-986981adbca14c679c4798623e74b4de", "input": "along with their biological evaluation against HIV and cancer cell proliferation , is reported.", "output": [ "finding" ] }, { "id": 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"purpose" ] }, { "id": "task1163-9386e17fcd7c404286616e1311f6ed14", "input": "Excellent or satisfactory agreement was obtained for all viruses ( k N 0.6 ) except Parainfluenzavirus 4 ( k = 0.24 ) and influenza B ( k = 0.51 ).", "output": [ "finding" ] }, { "id": "task1163-d2908b798aa3471eb5346612be9fe2ed", "input": "Our model is initialized using the daily counts of active and confirmed COVID-19 cases across the US.", "output": [ "method" ] }, { "id": "task1163-7587ff3ca45d490fa249812866b02755", "input": "This study aimed to understand the state of IDSR implementation and differences between guideline and practice for future disease surveillance system strengthening.", "output": [ "purpose" ] }, { "id": "task1163-3e2d4a7fe9b24014bf3ee3571e8e1f20", "input": "Objectives : To evaluate the prevalence of HCoV-NL63 in hospitalized adult patients and to perform molecular characterization of Italian strains.", "output": [ "purpose" ] }, { "id": "task1163-9d8026e1605f42e098b0ec8f1a217379", "input": "CaKoV infection was detected in four diarrheic samples ( 19.0 % ) and five non-diarrheic samples ( 13.2 % ).", "output": [ "method" ] }, { "id": "task1163-10db7529186944cab9c3e91448293703", "input": "points to a novel mechanism of antiviral action.", "output": [ "finding" ] }, { "id": "task1163-ca728f7eb0fe4fb6b5ec5a07f3119ffe", "input": "Background : Infectious bronchitis virus ( IBV ) is a Gammacoronavirus of the family Coronaviridae and is a causative agent of an economically important disease in poultry.", "output": [ "background" ] }, { "id": "task1163-3b6e24e6af464f6cb84492ac5d8c2260", "input": "ICU admission , 33 recovery and death of COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-2216b728cbbd4c8d9695da0465ca614f", "input": "However , DAAs can be undermined by the emergence of drug resistant mutant viruses.", "output": [ "background" ] }, { "id": "task1163-4e055b1bab5d43cfa887013b1bd9538c", "input": "at present , the interplay between autophagy and BVDV remains unclear.", "output": [ "background" ] }, { "id": "task1163-b775e8c037b14922addd544fd12b164e", "input": "The same was true for the antipyretic model.", "output": [ "finding" ] }, { "id": "task1163-50f8bf27ed06442bbf5824e15d7f5330", "input": "and 1 or more systemic antibiotics ordered.", "output": [ "method" ] }, { "id": "task1163-bd5e7406b8f141d8b5a67a540b410a3a", "input": "We aimed at generating a non-functional mAb directed against NAG-2 from patients ' memory B cells.", "output": [ "purpose" ] }, { "id": "task1163-2379fa236b414b79809103ba38fb4f55", "input": "S. aureus strains susceptible to methicillin were isolated from samples from the physician and from 5 other health care workers.", "output": [ "finding" ] }, { "id": "task1163-48618554f51d4887ae4aeb55aa350f8b", "input": "Furthermore , exposure to a common but still unidentified source can not be ruled out.", "output": [ "finding" ] }, { "id": "task1163-de3261e33fee4000970e024efab0234e", "input": "PI3K-Akt-mTOR signaling pathway plays a vital role in regulating the infection course of many viruses.", "output": [ "background" ] }, { "id": "task1163-40ca683e28d54b9785869bbd8f0575d1", "input": "ORF1a and ORF1b , which encodes 16 non-structural proteins.", "output": [ "background" ] }, { "id": "task1163-9c7479c08f964da9a86f29a97c59b4f1", "input": "and during this time , antibody engineering has dramatically evolved.", "output": [ "background" ] }, { "id": "task1163-bcc6811415644771b740f1b2ea986cb9", "input": "and determining its effect on macrophage activation for in vitro elimination of HsV-1 infection.", "output": [ "purpose" ] }, { "id": "task1163-7b8a35c7b9eb4855b0c962014346bfcf", "input": "likely because of the implementation of lung-protective ventilation.", "output": [ "finding" ] }, { "id": "task1163-67ff40d275354f4883f36b86519eda2e", "input": "for example , Giardia lamblia infection and to identify long-term changes in the pattern of infections related to altered dietary habits and other social factors.", "output": [ "background" ] }, { "id": "task1163-0bb10d80cbed42fcacc0b18cb9656f3e", "input": "No specifi c drug treatment exists for MERS and infection prevention and control measures are crucial to prevent spread in health-care facilities.", "output": [ "background" ] }, { "id": "task1163-3ba111b69f194fefac49ad6d93867b12", "input": "including antiviral effects and cytotoxicity.", "output": [ "background" ] }, { "id": "task1163-02aad39f95964549b0b4586b727822b0", "input": "The TB bacillus kills more people than any other infectious agent alone.", "output": [ "background" ] }, { "id": "task1163-160fd25f51c642728badeccf6b91375c", "input": "year , and health care system.", "output": [ "method" ] }, { "id": "task1163-88ea782a573f47e5be6622a181d8e55c", "input": "Proteins that are only temporarily rendered soluble by fusing them to MBP are readily identified at this stage because they will precipitate after the MBP tag is removed by 3C protease.", "output": [ "method" ] }, { "id": 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"task1163-64de365bb3ca4fc6be708caf42731a12", "input": "Recent advances in chemical protein synthesis and ligation methodology has yielded novel reagents for use in ubiquitylation research.", "output": [ "background" ] }, { "id": "task1163-8836b13b30dd4e2cae54deca6d24733b", "input": "The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high ( H III ) and low ( L III ) antibody responsiveness.", "output": [ "purpose" ] }, { "id": "task1163-77d3a3ea63d541c09a90eda4ab932ab5", "input": "In addition , HBV transactivator protein HBx stabilized CRTC1 and promoted its activity on HBV transcription.", "output": [ "finding" ] }, { "id": "task1163-c723c7ca50b84a6e89e4bb5fad1dbfd7", "input": "there is a dose response relationship between domestic exposure and sensitization.", "output": [ "background" ] }, { "id": "task1163-999982f768384cb0a8051f3150414d2b", "input": "bone marrow stromal cells , fibroblasts and occasional polymorphonuclear leukocytes.", "output": [ "finding" ] }, { "id": "task1163-3ab5340c1509458b8115b04d6cad3793", "input": "the historical information of clinic hospitalization caused by influenza infection between years 2009 and 2016 were extracted and assembled from public records of Tokyo and Hokkaido , Japan.", "output": [ "method" ] }, { "id": "task1163-31a9c562fc0e47fdb0a8f355d61c6669", "input": "Therefore , the study considers analysis method issues and raises questions about the value of structured data and merits of the recognition of if-then conditions by research methods such as long interviews.", "output": [ "finding" ] }, { "id": "task1163-7b533bd0d29a4666bce7d6fe99b11ab3", "input": "This is the first time that recombination events have been directly identified in fungal partitiviruses and in G. abietina in particular.", "output": [ "finding" ] }, { "id": "task1163-08f6626167404dac982ceac1fd9df28c", "input": "if effective when worn under routine circumstances.", "output": [ "background" ] }, { "id": "task1163-ee26c83368a24e13b74092f6c1f523c1", "input": "on the botany , phytochemistry and pharmacology of Cassiae semen.", "output": [ "purpose" ] }, { "id": "task1163-77ec7bd5bd2249928816f0be859778ee", "input": "which differ at different levels of the global health architecture.", "output": [ "purpose" ] }, { "id": "task1163-a784882a09a94631a7528b3309d4ee07", "input": "Next , the investigation validated the model using two sets of experimental data from a cabin mockup and an actual airplane.", "output": [ "method" ] }, { "id": "task1163-8fc3c107f2964baeb3a95c7e5e2858d9", "input": "has resulted in potent anti-rotavirus activity.", "output": [ "finding" ] }, { "id": "task1163-e582cb87233c4935bdcc973ec34dd5db", "input": "Then , 0.5 μL of the resulted PCR amplicon was further subjected to the second round PCR following the abovementioned parameters.", "output": [ "method" ] }, { "id": "task1163-fd0a8ba0867f4aa78fd1140babe766f8", "input": "Further clarifying the mechanism by which autophagy regulates the immune system is essential for elucidating the precise mechanisms of various diseases and for developing new treatment methods.", "output": [ "purpose" ] }, { "id": "task1163-8a722f3064384b059a46cf83a6f73f37", "input": "replication initiation sites , and 5 0 - and 3 0 - untranslated region ( UTR ) of mRNA.", "output": [ "background" ] }, { "id": "task1163-944d33ff8f8649f092bcbb8d5fbbb30a", "input": "All mice were vaccinated i.m at day 28 and boosted at day 56 with 10-valent inactivated HRV that included types 16 and 76 ( 10-valent composition listed in Supplementary Table 2 ).", "output": [ "method" ] }, { "id": "task1163-790ba0521bf745bb95b1e45bcb51f4e4", "input": "Despite numerous unprotected exposures , there was no serologic evidence of healthcare-related SARS-CoV transmission.", "output": [ "finding" ] }, { "id": "task1163-0c473a7850c742989a8be07d23220eae", "input": "HCW with onset of illness in the same 10-day period were contacted and asked whether they have been diagnosed with pneumonia.", "output": [ "method" ] }, { "id": "task1163-b307870cec41426296af974bbb3be90d", "input": "These findings provide evidence for a novel mechanism by which PPARA attenuates hepatic inflammasome activation in response to metabolic stress through lncRNA Gm15441 induction.", "output": [ "finding" ] }, { "id": "task1163-98ef4a9f4a9347fcb0958f20a5334f17", "input": "The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus ( VZV ) replication in HEL cell cultures.", "output": [ "finding" ] }, { "id": "task1163-895d16a38a2c4c1f963e80f831bf3bf7", "input": "Long-term changes in symptoms and changes in vital signs were correlated back to and compared with the severity of the initial H1N1 influenza infection.", "output": [ "method" ] }, { "id": "task1163-515c7ef8cc5949ee8f8d71472d7c937a", "input": "V55P displayed a substantial reduction ( ف 60-80 % ) in the initial rate of lipid mixing.", "output": [ "finding" ] }, { "id": "task1163-97df4bbc72f646af8ca3ded30601223b", "input": "Pleural effusion , when observed , was typically minimal.", "output": [ "finding" ] }, { "id": "task1163-f5c065a099de483ea7510635a501e7de", "input": "at least in part , studied separately during infection with positive-stranded RNA virus.", "output": [ "finding" ] }, { "id": "task1163-a51a11f0b4364e879cab36a3d3bd64cf", "input": "Written RPPs for each hospital were evaluated.", "output": [ "method" ] }, { "id": "task1163-9c95eba414ca4aff9b77d3f7eea87638", "input": "while it fell below 5 % in death cases.", "output": [ "finding" ] }, { "id": "task1163-0336cbce85854a31bcde35ed2f4a509c", "input": "We constructed speci ¢ c siRNAs targeting the S gene in SARS-CoV.", "output": [ "method" ] }, { "id": "task1163-40f048ad5151402582ea32faa7e47a97", "input": "resources , and technical equipment among European isolation facilities.", "output": [ "purpose" ] }, { "id": "task1163-800cbc316ed0497a82c228e1948603f2", "input": "a city located in the foothills of the Himalayas.", "output": [ "purpose" ] }, { "id": "task1163-31fa2a2541ee421fbea26ebf2360ff8c", "input": "allowing estimation of the HIV incidence and the time-dependent rate of diagnosis.", "output": [ "method" ] }, { "id": "task1163-779117bbd0ce4eaa824534f2f5a02fae", "input": "Here , we define mutations in influenza A subtype H5N1 ( avian ) HA that alter its specificity for SA either by decreasing α2 ,3 or increasing α2,6-SA recognition.", "output": [ "purpose" ] }, { "id": "task1163-b9b5990701fd4bfb9b32643b879bc4cf", "input": "capturing thus the early exponential growth in a rather homogeneous way.", "output": [ "method" ] }, { "id": "task1163-cd7a7023bd144af6b14ad3e950bc41ea", "input": "The paper mainly applies the information categorization method to analyze the financial time series.", "output": [ "method" ] }, { "id": "task1163-3c6263d31f004a47b85775a75bfe7d25", "input": "Then MDBK , GFP-LC3-MDBK and shBCN1-MDBK cells were infected with CP or NCP BVDV strains.", "output": [ "method" ] }, { "id": "task1163-8dd2a31549394090a10d06df6e320d4e", "input": "A key strategy in the program is to test for presence of antibodies and protect testnegative herds from infection.", "output": [ "background" ] }, { "id": "task1163-d2ea5d08c7434b2d94ba6c8345d4fd5a", "input": "Furthermore , heparin was able to inhibit the interaction of the viruses with the heparan sulfate and to block cell-mediated trans-infection of henipaviruses.", "output": [ "finding" ] }, { "id": "task1163-d2ea63850e7145bd819d68308257a622", "input": "and suggests possible solutions to some of the main bottlenecks to routine implementation.", "output": [ "purpose" ] }, { "id": "task1163-fc64c2612a0a450d96d444654c0f38f4", "input": "Data were gathered during 149 outbreaks of norovirus in hospital wards from five hospitals in two major cities in England serving a population of 2 million.", "output": [ "method" ] }, { "id": "task1163-368fc495c1824a4bbf2cf0301fb50ea3", "input": "or ( c ) using RNA secondary structural motifs to antagonize IFIT1 binding.", "output": [ "finding" ] }, { "id": "task1163-78a3d0a19a7741b18f65b866a25f6bef", "input": "with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides.", "output": [ "purpose" ] }, { "id": "task1163-b6aec844afdd4d329d3be1ee086f14bb", "input": "Swabs were tested by polymerase chain reaction for 17 respiratory viruses and seven respiratory bacteria.", "output": [ "method" ] }, { "id": "task1163-99348b5d714a4e85818e646a2acdf3a4", "input": "In this review , we provide a detailed discussion of the currently developed biosensors based on the aforementioned unique optical features of GNPs.", "output": [ "purpose" ] }, { "id": "task1163-d63d8e2967fa4a34b86524b46e8b1ed0", "input": "likely because N63Y mutant CVB3 disseminates more efficiently to the liver.", "output": [ "finding" ] }, { "id": "task1163-10a239d128b94a1a99a3f7d9eac5fa1f", "input": "As such , ARDS represents a major public health problem.", "output": [ "background" ] }, { "id": "task1163-1f330c14f6844d5c81c28c640ae897bb", "input": "and township and village enterprises ( TVEs ).", "output": [ "method" ] }, { "id": "task1163-d94da2e9e7b2438da520d812d6bda91e", "input": "Here , we further characterize these and other fragments in an attempt to identify possible dimerization domains and their role for membrane fusion.", "output": [ "purpose" ] }, { "id": "task1163-42edb0eaa92a45198ed08948f2dc7afa", "input": "Health care payers increasingly expect that the results of evidence-based economic evaluations will guide practitioners in their choice of cost-effective interventions.", "output": [ "background" ] }, { "id": "task1163-8bad64c1c1234d05b47d73d856511138", "input": "Here we explore the unusual relationship of this medically important family of viruses with a degradative mechanism of innate immunity.", "output": [ "purpose" ] }, { "id": "task1163-454d99f5d7df4b609fe1449ed6e7450d", "input": "Vaccination continues to have a major impact on the health of humans and animals.", "output": [ "background" ] }, { "id": "task1163-cc9fccf544ee47b58066710e8a37e6c6", "input": "with a focus on those diseases for which NA testing is now considered the standard of care and highlights the unique challenges and opportunities that these tests present for clinical laboratories.", "output": [ "purpose" ] }, { "id": "task1163-32ddf871aaa246e0a25a471c3d844f96", "input": "During a normal weekday , an individual may visit several locations in different location groups with a fixed order.", "output": [ "method" ] }, { "id": "task1163-b88fbd876eb34121b86ae040d4912716", "input": "These parameters correlated with conventional assessment of clinical disease in a vaccine eficacy study.", "output": [ "background" ] }, { "id": "task1163-239a50e2176545d6a6fb5e7644d0146a", "input": "The affinity of the parental mAb and the cloned Fab to the MalE-E ( 296-400 ) fusion protein were shown to be of the same magnitude , i.e. nanomolar.", "output": [ "finding" ] }, { "id": "task1163-4b16a955496343c8a896020838bccf62", "input": "The results presented here show that cholesterol-rich lipid rafts are important for the CyHV-3 replication cycle especially during entry and egress.", "output": [ "finding" ] }, { "id": "task1163-a7a1b83cd6b94c9ba0010b8c2ac5491f", "input": "weaknesses , opportunities and threats for TCM.", "output": [ "purpose" ] }, { "id": "task1163-167e94637cfd44aab53a9240c59852e2", "input": "but higher procalcitonin strongly correlated with increased probability of bacterial pathogens , particularly typical bacteria.", "output": [ "finding" ] }, { "id": "task1163-4e94ff801e354fb48b63a2daa56e6016", "input": "We also looked at the impact of medication history on virus transmission.", "output": [ "purpose" ] }, { "id": "task1163-333725edbf904e9ba73667a0b7ffcac2", "input": "Part of this study is targeted at evaluating the effectiveness of public health control measures implemented during the SARS epidemic.", "output": [ "method" ] }, { "id": "task1163-df852beca6d3492ca12778cca501998d", "input": "In addition , there is considerable interest in the use of G-quadruplexes for biomaterials , biosensors , and biocatalysts.", "output": [ "background" ] }, { "id": "task1163-f7fb0fba8ec74a6492954f73654c0072", "input": "Viruses with mutations in nsp5 and nsp16 produced small DMVs but also replicated normally.", "output": [ "method" ] }, { "id": "task1163-8b622b8999bc4ae0bed8e0afd385fa37", "input": "with special reference to the ( i ) genome structure ; ( ii ) clinical features ; ( iii ) diagnosis of infection ; and ( iv ) treatment and vaccine development.", "output": [ "purpose" ] }, { "id": "task1163-8c48071b3cf54013be15de38035ce001", "input": "A dose of 4 mg/kg q24 h for four days was found to be the optimal treatment protocol : 2 mg/kg cleared only 80 % of cats.", "output": [ "finding" ] }, { "id": "task1163-9a69cbd470c74a5da58cb8de1d09dbfb", "input": "Method A computer-assisted phone survey was conducted among 3,436 respondents.", "output": [ "method" ] }, { "id": "task1163-b297a15440964d439f49ab7ee5d4c8b3", "input": "indicating that additional roles in viral replication might be played by this protein.", "output": [ "finding" ] }, { "id": "task1163-29e5ed517dc3425a831178623939f186", "input": "Each MS11 Opa protein recognizes a distinct spectrum of CD66 receptors.", "output": [ "background" ] }, { "id": "task1163-9f65cf8ea37e480db0592407e45c534c", "input": "In bivariate analysis , both optimism and pessimism were related to unplanned c-section.", "output": [ "method" ] }, { "id": "task1163-e9dbf4b343b9420e937c7ebda3e4bb0f", "input": "PCR and mycologic analysis of pulmonary samples in both neutropenic and nonneutropenic patients.", "output": [ "method" ] }, { "id": "task1163-9e116f255aac4fce8c9d49cf97514c6e", "input": "GPAP is also caused by mutations in genes whose products are implicated in surfactant catabolism in alveolar macrophages ( AMs ).", "output": [ "background" ] }, { "id": "task1163-d6c8ee7cc6c3476fb80d4199e8f615eb", "input": "The present study sought to identify the structural proteins that possess the immune evasion properties in immortalized porcine alveolar macrophages ( PAM ).", "output": [ "purpose" ] }, { "id": "task1163-959d9fca5a214aa09056f7394928caeb", "input": "The use of small animal models for the study of infectious disease is critical for understanding disease progression and for developing prophylactic and therapeutic treatment options.", "output": [ "background" ] }, { "id": "task1163-700b14130a7c4cc3a10144a8095671fa", "input": "and then encapsulating it using microemulsion.", "output": [ "purpose" ] }, { "id": "task1163-df49c6cf860c437491ae8ed2d0fea8cf", "input": "butchering and consuming the species offered.", "output": [ "purpose" ] }, { "id": "task1163-7fcc7971a06c45d1a1f4185052eca798", "input": "pulmonary pharmacokinetic properties and safety.", "output": [ "purpose" ] }, { "id": "task1163-3b60976e1def4906a2bc0add638855f8", "input": "and he was sent home with anti-diarrheal medications.", "output": [ "background" ] }, { "id": "task1163-76e196aeeed740fa819cf48c47bdf6c8", "input": "In the present study , the cellular protein response to DTMUV infection in duck ovarian follicles was analyzed using nanoflow high-performance liquid chromatography-electrospray tandem mass spectrometry.", "output": [ "purpose" ] }, { "id": "task1163-a88f30c1f0fd4040a8693cc6d832eb58", "input": "We also note that noise blurs the line between oscillatory and non-oscillatory behavior.", "output": [ "finding" ] }, { "id": "task1163-3254a0e7dc804403b160fc4d56b9fb2d", "input": "Consistent risk factors are birth weight and prematurity.", "output": [ "background" ] }, { "id": "task1163-7d303e8d14cd4eb2b797c00c45f0746d", "input": "Additionally , the TW I attenuated vaccine strain had no reversion to virulence after five back passages in chicks.", "output": [ "finding" ] }, { "id": "task1163-df64d7529e514d329e736d118199da31", "input": "this effort is not likely to be wasted because it will also support the health of both patients and staff in normal times.", "output": [ "finding" ] }, { "id": "task1163-e964a9b18eb5441b9c158a1c4277944b", "input": "Our goal here is to reiterate the original message and highlight future directions.", "output": [ "purpose" ] }, { "id": "task1163-9a1755f8167647ec9c9de9c617041592", "input": "We measure the accuracy of the classification algorithms based on the level of human curation necessary to correct misclassifications , and examine geographic coverage.", "output": [ "method" ] }, { "id": "task1163-6b5d5f7ef17c4ea48a668724806015bc", "input": "Here we present the 4.0 Å resolution structure of the trimeric HKU1 S protein determined using singleparticle cryo-electron microscopy.", "output": [ "purpose" ] }, { "id": "task1163-a333db6b0bdc43639c9f607177decdb3", "input": "a clear understanding of dengue pathogenesis remains elusive.", "output": [ "background" ] }, { "id": "task1163-9c57d8a9c3754f87b5df2d02908c8315", "input": "was applied to 27 healthy volunteers for 24 h and some volunteers were vaccinated again by TCI formulation.", "output": [ "method" ] }, { "id": "task1163-fb0eb9b6be954e2c88f5ce283f87192e", "input": "In addition , 120 rectal swabs were collected from 120 healthy foals in 2012.", "output": [ "method" ] }, { "id": "task1163-bf5d0d4f03fe46af95d45d31678c6803", "input": "resulting in attenuation of the type I interferon IFN-b.", "output": [ "background" ] }, { "id": "task1163-5cb5abb325fc4aed97003c9c45bb7f9f", "input": "Results : In ELISA , the levels of anti-cercarial IgM peaked on day 15 pi.", "output": [ "finding" ] }, { "id": "task1163-44730a4af83c407ea3bce9eba72799db", "input": "solubility , membrane insertion kinetics , and protease sensitivity.", "output": [ "purpose" ] }, { "id": "task1163-37b1e13919cd42cabad4a9e618b65df9", "input": "The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis.", "output": [ "finding" ] }, { "id": "task1163-1ed0597791984b44bcf0ba523f292106", "input": "we demonstrate that viral expansions into historically uninfected zones have doubled the recent burden of VBR.", "output": [ "purpose" ] }, { "id": "task1163-911c18c419054c47bf1954a77d8d6ffd", "input": "in-hospital mortality , and 1-year mortality of ARDS in Taiwan.", "output": [ "purpose" ] }, { "id": "task1163-bd4d796258fc43d4b7bc15de9314f7f6", "input": "Real-time quantitative RT-PCR analysis of abraded tracheal epithelium revealed a higher expression of cav-2 than of cav-1.", "output": [ "method" ] }, { "id": "task1163-41385578db044ed082746e4cd64f71cd", "input": "suggesting that this region is inherently flexible and may be important for RSV F function.", "output": [ "finding" ] }, { "id": "task1163-5e83307a165a49ccba278f298612be08", "input": "are predominantly the hosts of zoonotic emerging and re-emerging infectious diseases ( EIDs ).", "output": [ "purpose" ] }, { "id": "task1163-3a4cd823fa09410689fa15f687e62325", "input": "and ( 4 ) measure all appropriate AECB-associated costs , both direct and indirect.", "output": [ "finding" ] }, { "id": "task1163-f700b997cfaf4dd8ba581297af0c77b1", "input": "A likelihood-based approach was used to obtain parameter estimates.", "output": [ "method" ] }, { "id": "task1163-4b7c9163160c443486f8af91987ec94f", "input": "Their heterogeneity was investigated by analysis of the ORF3 gene because of its potential function as a representation of virulence.", "output": [ "method" ] }, { "id": "task1163-67baba170e3c4af89f8f3b56325db04b", "input": "Fluorescence immunohistochemistry was performed to locate caveolae and cav-1 and -2 in the airway epithelium of rats , mice and humans.", "output": [ "method" ] }, { "id": "task1163-4e08efa937624a85917c8f4f9c848cee", "input": "we performed studies to evaluate the ability of each cell line to support specific steps of the viral lifecycle ( i.e. entry , replication , egress and spread ).", "output": [ "method" ] }, { "id": "task1163-2c396368d6284735ad1ef95d5c265eb4", "input": "In this article , we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu , China.", "output": [ "purpose" ] }, { "id": "task1163-73e51bbd4d314ab89f240e12f2aa73d9", "input": "Competitive growth assays were carried out in both continuous and primary cells to better understand the contribution of DMVs to viral fitness.", "output": [ "method" ] }, { "id": "task1163-cb53083719e1439395d87db5fd48ac2b", "input": "tracheal ciliary protection was assessed.", "output": [ "method" ] }, { "id": "task1163-25bead5b654e493ab54a6e3aae901769", "input": "to ensure an unbiased result.", "output": [ "finding" ] }, { "id": "task1163-14eb12658cce4870b50075df0af19eff", "input": "The main purpose of this study was to evaluate the long-term effects of VRTI during the first year after lung transplantation in relation to CLAD development.", "output": [ "purpose" ] }, { "id": "task1163-d539c6f079a64e80bea7e63208f6d15f", "input": "Madin-Darby bovine kidney cells stably expressing microtubule-associated protein 1 light chain 3B ( LC3B ) with green fluorescent protein ( GFP ) ( GFP-LC3-MDBK cells ) and autophagy-deficient MDBKs ( shBCN1-MDBK Yulong Zhou and Yachao Ren have contributed equally to this work.", "output": [ "finding" ] }, { "id": "task1163-e44d30e376224dd3b1ac9724843bf13d", "input": "Thus , it is important to expand our knowledge of the presence of viruses in bats which could represent a risk to humans.", "output": [ "purpose" ] }, { "id": "task1163-aa3461cf59a14d1aa9b762313185ee23", "input": "and will never be medically evaluated.", "output": [ "background" ] }, { "id": "task1163-a79ad4e5a16841d0804acc9c9d5bbf28", "input": "but did not significantly compromise the contribution of E to efficient VLP production.", "output": [ "finding" ] }, { "id": "task1163-d82a0619499f492bbad49e1d7698641d", "input": "semiurban , and rural areas.", "output": [ "method" ] }, { "id": "task1163-ab5b0231644b44d287fceae74c3f6635", "input": "proteins expression in DEV infected duck embryo fibroblasts ( DEFs ) within 24 h post-infection ( p.i. ) was also effectively suppressed by resveratrol.", "output": [ "finding" ] }, { "id": "task1163-ccc3026f15dc49b68093321d868cb400", "input": "has evaluated the ventilation performance of three strategies in the protection of health care workers and HVAC control for airborne infectious diseases induced by contaminated exhaled air from patients in a negative pressure isolation room.", "output": [ "purpose" ] }, { "id": "task1163-cfb599b2fc4d4b9fbe4876db6448064d", "input": "The synthesis of genomic RNA and all eight subgenomic mRNAs was faithfully reproduced by the RTC in this in vitro system.", "output": [ "method" ] }, { "id": "task1163-f83241ee7d0f4537bf4755a28ce91f3a", "input": "In this review , we focus on adjuvants that can enhance the immunogenicity of DNA encoded antigens and highlight the development of a novel cytolytic DNA platform encoding a truncated mouse perforin.", "output": [ "purpose" ] }, { "id": "task1163-f05282fea818467cb68763a0f12679bf", "input": "Methods : All patients admitted with findings consistent with CAP were included.", "output": [ "method" ] }, { "id": "task1163-1dff2db4440141fbb32058240b8bb611", "input": "Logistic regression was used to investigate associations between child characteristics and codetection of the organisms of interest.", "output": [ "method" ] }, { "id": "task1163-fa61f48e9037490ebe79cb4882ccc486", "input": "which correlated with axonal and dendritic plasticity.", "output": [ "background" ] }, { "id": "task1163-17dacb6fb8f040fda455be25fc38878f", "input": "dipeptidyl peptidase 4 ( DPP4 ).", "output": [ "background" ] }, { "id": "task1163-8691a7b84cc54296b5c6665c0569663f", "input": "A cluster analysis procedure for the functional classification of binding pockets was implemented and calibrated using a diverse set of enzyme binding sites.", "output": [ "method" ] }, { "id": "task1163-a6a619f456c04606a0990e4a224d8acc", "input": "To provide scientific basis for promoting the physical and psychological health of these staff members.", "output": [ "purpose" ] }, { "id": "task1163-8814180f9bc945dfa3fbdacd0bb6d279", "input": "In this report , we describe the discovery and genomic characterization of partetraviruses in bovine and ovine samples from China.", "output": [ "purpose" ] }, { "id": "task1163-9184a0ed74cf42a6b04c2941afa95b8b", "input": "in which all the steps here depicts our experience and expertise combined with the already well-known and accepted international guidance.", "output": [ "purpose" ] }, { "id": "task1163-eb7396e339c44803a1f5d6bc955ea1de", "input": "In this article we review recent progress in the fi eld of pathogen surveillance and discovery with a specifi c focus on applications in the fi eld of laboratory animal research.", "output": [ "purpose" ] }, { "id": "task1163-16d9ca85d4094cdea0eff89c55863afb", "input": "The estimations based on likelihood and model analysis show that the control reproduction number may be as high as 6.47 ( 95 % CI 5.71-7.23 ).", "output": [ "finding" ] }, { "id": "task1163-cf14e1a15ae04d2da057869ff447e10a", "input": "plays a protective role in pathogenesis of acute lung injury.", "output": [ "background" ] }, { "id": "task1163-758925c07384443bb4c773a0b2535db1", "input": "Using the best classification models for antibiotic and antitumor activities a data set of marine and microbial natural products from the AntiMarin database were screened-57 and 16 new lead compounds for antibiotic and antitumor drug design were proposed , respectively.", "output": [ "method" ] }, { "id": "task1163-78cf03d8920c45b6bee3ef89605153d1", "input": "Different prediction tools were used to analyze the aforementioned protein at Immune Epitope Database ( IEDB ) to discriminate the most promising Tcell and B-cell epitopes.", "output": [ "method" ] }, { "id": "task1163-924958f2b83b474dbbee03b0eda141fc", "input": "this study provides empirical and theoretical evidence that the risk of disease transmission varies substantially based on the animal and herd demographic characteristics at the time of purchase.", "output": [ "purpose" ] }, { "id": "task1163-6435de9b1251453885f8faf17ad43828", "input": "Wuhan , December 2019 and subsequently reached other provinces/regions of China and other countries.", "output": [ "background" ] }, { "id": "task1163-f0f9573d6bc746a08cb017aa035d8f67", "input": "respectively , and compare these findings with previous results from the beet western yellows virus ( BWYV ) RNA.", "output": [ "method" ] }, { "id": "task1163-efe5fc25c7d043d9b91f18ef2843c1db", "input": "respirators , soap and alcohol-based hand sanitizers.", "output": [ "finding" ] }, { "id": "task1163-403cfb59f8e64623b2ee14ed77578161", "input": "Paramyxovirus infections can be detected worldwide with some emerging zoonotic viruses and currently there are no specific therapeutic treatments or vaccines available for many of these diseases.", "output": [ "background" ] }, { "id": "task1163-b72811eb012b4fcea39e21e4866d8639", "input": "synthetic , DNA vaccine targeting the pre-membrane + envelope proteins ( prME ) of ZIKV.", "output": [ "purpose" ] }, { "id": "task1163-763867da4920431881d329e1bb51acfd", "input": "We conclude that there was a synergism between oxygen and ozone exposure leading to enhanced epithelial injury and metaplasia.", "output": [ "finding" ] }, { "id": "task1163-9fd7a50d77ff4b1eb094d7e595072a1d", "input": "spore-forming anaerobic bacteria and viruses ( coronavirus , parvovirus , adenovirus , parainfluenza virus ).", "output": [ "method" ] }, { "id": "task1163-8666cfcaf8664b5cb1f1f99684b334e1", "input": "We aimed to obtain a model to predict SARS-CoV-2 infection in suspected patients reported to the Brazilian surveillance system.", "output": [ "purpose" ] }, { "id": "task1163-ff408693852e427385a0605f4fdcabe5", "input": "reduced weight gain , and can lead to the development of necrotic enteritis.", "output": [ "background" ] }, { "id": "task1163-037c7e4f32974237b27fbe5b77664b51", "input": "Prompt recognition , isolation and management of suspected cases are key factors for prevention of the spread of MERS.", "output": [ "finding" ] }, { "id": "task1163-80301229a9b0496f8add4dab58b33b52", "input": "Animals : Cross-sectional study using a convenience sample of 95 preweaned dairy calves from 11 dairy herds.", "output": [ "method" ] }, { "id": "task1163-3dc04e2e8b384d1ead6902d76da11359", "input": "was submitted to the Animal and Plant Quarantine Agency for diagnosis.", "output": [ "background" ] }, { "id": "task1163-91946f8fcc5e4119b8044007bb0f843c", "input": "which is based on the synergistic combination of the yeast surface display ( YSD ) technique and the microfluidic technology.", "output": [ "background" ] }, { "id": "task1163-12620803f19f472ca03c39196b591b29", "input": "Five-week-old conventional pigs were inoculated intratracheally with the Lelystad strain of PRRSV and received 5 days later one or two intratracheal LPS administrations.", "output": [ "method" ] }, { "id": "task1163-730b9d623a4448ef8e83bc21a1df82c7", "input": "This article explores the principles that govern the assembly of such a system.", "output": [ "purpose" ] }, { "id": "task1163-fbb8036989b848968bcb56be2dc06fde", "input": "Together , the work demonstrates the utility of the infectious clone and provides a resource to rapidly manipulate the DENV1 serotype for generation of recombinant and mutant viruses.", "output": [ "finding" ] }, { "id": "task1163-e86c8f6b5a6444d6aae20570b0b6e07a", "input": "Methods : In 2014 , volunteers from two large participatory surveillance panels in the Netherlands and Belgium were invited for a survey.", "output": [ "method" ] }, { "id": "task1163-31ffbd35abcc4d968d7b7ff4d2b30342", "input": "particularly in high-risk persons in this highly fluid border population.", "output": [ "finding" ] }, { "id": "task1163-44ad37e55f4147e3a5c365c92ebab59b", "input": "Enriched male mice and male and female rats exhibited decreased feed intake without a subsequent decrease in body weight ; this may have been the result of the nesting material reducing the effect of cold stress thereby allowing for more efficient use of feed.", "output": [ "finding" ] }, { "id": "task1163-8891ec5e84504fdfbe91b5d7c9086a07", "input": "Moreover , biological components in PM were critical in mediating immune-related inflammatory responses and should therefore not be overlooked.", "output": [ "finding" ] }, { "id": "task1163-dc035617c1d44c2aa33112c438c12c59", "input": "selective pressures on West African BAGV sequences and their evolutionary phylogenetic relationships with previously available BAGV genomes.", "output": [ "method" ] }, { "id": "task1163-d8d31ba3700742e590486dd73f75cad4", "input": "Sequence analysis of the cDNAs synthesized from mRNA 4 revealed a major difference with previously published results.", "output": [ "background" ] }, { "id": "task1163-70e66ee4b7b54fd5be49a88e7800ded6", "input": "The aim of this study is to examine how TSLP production by IECs is regulated in ulcerative colitis.", "output": [ "purpose" ] }, { "id": "task1163-4ed596c4a6004a4abdeae16b26f6cad3", "input": "which has been shown to support SARS coronavirus replication.", "output": [ "method" ] }, { "id": "task1163-05ed30d5d34b4d9a8246280f3add2867", "input": "Thus , both host and viral factors are required for efficient hematogenous dissemination of reovirus.", "output": [ "finding" ] }, { "id": "task1163-6f57b53c4a434677ac3d755107884c1f", "input": "The aim in this study was to assess the effectiveness of a quaternary ammonium chloride ( QAC ) surfactant in reducing surface staphylococcal contamination in a routinely operating medical ward occupied by patients who had tested positive for methicillin-resistant Staphylococcus aureus ( MRSA ).", "output": [ "purpose" ] }, { "id": "task1163-11b789e354a84ceb91ff4ed50335acc0", "input": "Numerical analysis compares the effects of different building morphology modifications on pedestrianlevel natural ventilation.", "output": [ "method" ] }, { "id": "task1163-6135c9dd469440d790cfd717649d63c0", "input": "Thus , iDCs were induced from peripheral blood mononuclear cells ( PBMC ) and performed to explore the expressions and phosphorylation of molecules in the two signaling pathways as well as secretions of inflammatory cytokines and interferons during EV71 replication.", "output": [ "method" ] }, { "id": "task1163-b0dc178a044b4fccb57419fa50e77b4c", "input": "Hence major attention has been focused on characterization of this protein.", "output": [ "background" ] }, { "id": "task1163-81f0453c4a2948279c7e24bafa63107d", "input": "As a result , therapeutic antibodies have become the predominant class of new drugs developed in recent years.", "output": [ "background" ] }, { "id": "task1163-90dff574786d47919f9e9eba1a762960", "input": "Novel coronavirus pneumonia ( NCP ) severity was higher in the AMI patients than in patients with non-definite AMI ( p < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-faefa3ca7dd048c7a4f8710c895203c6", "input": "Here , we use simulated data to test the ability of both parametric and non-parametric methods for inference of effective population size ( coded in the popular BEAST package ) to reconstruct epidemic dynamics.", "output": [ "purpose" ] }, { "id": "task1163-75d569ab6b3e4864a8e2cd79dc1d909f", "input": "Additionally , we investigated the status of immunomodulatory pathways to determine their roles in tumor-treating fields-mediated immune activation.", "output": [ "method" ] }, { "id": "task1163-e09be0d186fd45e8b5ec19ae715ea9b8", "input": "and the value of specific B. pertussis therapy in this setting.", "output": [ "finding" ] }, { "id": "task1163-17f4a573c1fe428a8fa9c2e95ea270fa", "input": "Background : On-site vaccination arrangements were introduced in 2005 to improve influenza vaccination rate among employees of a 1500-bed tertiary hospital in Singapore.", "output": [ "background" ] }, { "id": "task1163-5ad372c67443416facf4273ae0d33645", "input": "respectively , died or were culled in the 120 d following diarrhea diagnosis.", "output": [ "finding" ] }, { "id": "task1163-e8f576166bcb4e088502907aa0889a15", "input": "This review aims to describe the transductional targeting strategies currently employed to specifically redirect viruses towards surface receptors on tumor cells.", "output": [ "purpose" ] }, { "id": "task1163-374ea25befa645c89be1c29c08181256", "input": "In this study , we investigated the systemic alterations of mtDNA-depleted ( r 0 ) mitochondria by using network analysis of gene expression data.", "output": [ "purpose" ] }, { "id": "task1163-42c3f354ceda45f6ad81d0e9e71e52a3", "input": "even if some were infected.", "output": [ "method" ] }, { "id": "task1163-4915ee7390b34268bbfd9878150ae6c4", "input": "In this article , we review current advances in neutralizing mAbs against MERS-CoV.", "output": [ "purpose" ] }, { "id": "task1163-b2845313f9d94b0ca271215fb0f69e31", "input": "33AE3 % in Nicaragua ( 95 % CI : 26AE6 ; 40AE1 ) and 25AE1 % in Peru ( 95 % CI : 18AE9 ; 31AE3 ).", "output": [ "finding" ] }, { "id": "task1163-3f58fd202b3045a3b915e7ac1a00a2bd", "input": "in a complex interplay , involving both synergistic and antagonistic effects.", "output": [ "background" ] }, { "id": "task1163-fcf06f023a5e4314985bef9f44216a71", "input": "Nevertheless , the WHO and the American Academy of Ophthalmology ( AAO ) III recommend wearing eye protection ( e.g. , goggles or shield ) when treating patients ( potentially ) infected with COVID-19 to prevent droplet transmission.", "output": [ "background" ] }, { "id": "task1163-662973cf296148f0b25d8b9a17e548c7", "input": "collecting different biological matrices during the entire period of infection.", "output": [ "method" ] }, { "id": "task1163-5b232029e15b45598f7cd55c5301e258", "input": "In this Review , we present important examples of viral RNA-based strategies to exploit the cellular translation machinery.", "output": [ "purpose" ] }, { "id": "task1163-fc2851b22e944294b132f03cdcd4edf1", "input": "Data were linked with surveys on health and social integration conducted at the end of 2019 ( N study sample = 3,540 ).", "output": [ "method" ] }, { "id": "task1163-df642c3e570f41ab986383fcada1a5f4", "input": "and whether ICU respiratory infections can predict influenza epidemics.", "output": [ "purpose" ] }, { "id": "task1163-1e29a1d3f11e4d318fa5ad3ba72fe233", "input": "The age-adjusted incidence of ARDS was 15.19 per 100,000 person-years.", "output": [ "finding" ] }, { "id": "task1163-f49a680de404424986b364ef13175715", "input": "an outer membrane protein , exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 ( HEp-2 ) and is shown to be highly immunogenic.", "output": [ "background" ] }, { "id": "task1163-b743e1702d754cf6925be2e97bb99cdf", "input": "In this Opinion article , we propose a synthetic framework for animal-to-human transmission that integrates the relevant mechanisms.", "output": [ "purpose" ] }, { "id": "task1163-aed6f866d385420797303f6307a698ba", "input": "of which , 1,065 genes were down-regulated and 326 genes were up-regulated in the LBW compared to NBW newborns.", "output": [ "finding" ] }, { "id": "task1163-594a76d40e984ea5bfa8c0e643f8f82a", "input": "where HCP became infected while caring for patients due to errors in the use of PPE.", "output": [ "background" ] }, { "id": "task1163-ca93540a9ddf47c383c7c17f69ae38f8", "input": "and PM − 10 indicated that TLR2 and TLR4 played a dominant role in the inflammatory responses of the lung.", "output": [ "finding" ] }, { "id": "task1163-a7fa33bb6c814b188d1ed01adc7a7cfe", "input": "and appraisal of crisis management.", "output": [ "method" ] }, { "id": "task1163-9742e59c816e46fe9e6bcc845ea3a561", "input": "Detection sensitivities of the multiplex assays were compared to singleplex reactions testing for the same targets.", "output": [ "method" ] }, { "id": "task1163-73ea28c12930404aaa36b04682d8cefb", "input": "examples of this contribution in two countries of the African region : Côte d'Ivoire and the Democratic Republic of Congo.", "output": [ "purpose" ] }, { "id": "task1163-120339f92704468c903135406e32a6fa", "input": "Fractures were most frequently found in the upper extremity of a child while the most common non-fracture location was head.", "output": [ "finding" ] }, { "id": "task1163-95b49f44eb764d04a5814cb5f98e7584", "input": "Objective : To explore socio-demographic data of the population as proxies for risk factors in disease transmission modeling at different geographic scales.", "output": [ "purpose" ] }, { "id": "task1163-42fe551bf1b845c0b57d14c783d64062", "input": "Background.", "output": [ "background" ] }, { "id": "task1163-42b53673e71a413aa5621ee374b365f5", "input": "most of the research is carried out in the Vero E6 cells.", "output": [ "background" ] }, { "id": "task1163-1a90ea0de46842e79fe857e71b2ad8dd", "input": "and how CD8 + T cell expansion and differentiation are controlled in these contexts.", "output": [ "purpose" ] }, { "id": "task1163-e4b3517a8870401ab3a5da7d1fcdae8c", "input": "providing information on optimal subcellular targeting for production in plant bioreactors.", "output": [ "finding" ] }, { "id": "task1163-6f43535e768b4e4482e808be7cf37a7f", "input": "has a lot more flexibility than its imine-based parent compound and an inverted hydrogen-bonding profile.", "output": [ "finding" ] }, { "id": "task1163-b6138670f8af4577a777a559b4c371c5", "input": "We also present data on the use of in silico docking in gaining insight into 2019-nCoV Spike-receptor binding to aid in therapeutic development.", "output": [ "purpose" ] }, { "id": "task1163-52c0d2c4088744b3b5fa504343d09e48", "input": "Optimization of the ELISA showed a capability of the assay to significantly distinguish HCoV-NL63 from HCoV-229E ( U = 27.50 , p < 0.001 ) and HCoV-OC43 ( U = 55.50 , p < 0.001 ) in coronavirus-characterized sera.", "output": [ "finding" ] }, { "id": "task1163-72854f19ffac4ab385d01d83680aef3a", "input": "and the patient required nasal oxygenation.", "output": [ "finding" ] }, { "id": "task1163-d898a662961343339d23b0cba7666f32", "input": "pathological , and immunological methods.", "output": [ "method" ] }, { "id": "task1163-aa685456b96c437c81efc2e93f6f22fa", "input": "we could monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale.", "output": [ "purpose" ] }, { "id": "task1163-3985f99785204ee88c9ad961152fe692", "input": "yet commonly not proven at the time of treatment initiation.", "output": [ "finding" ] }, { "id": "task1163-3d795aad8a9a4f1b9d7f84ed145e1420", "input": "This article describes the steps taken to implement expanded SARI surveillance in Vietnam and reports data from 1 year of expanded surveillance.", "output": [ "purpose" ] }, { "id": "task1163-62efb66feaa34fc08dc3ce8607cba8da", "input": "Emphasis is given to label-free electrochemical ( impedimetric , voltammetric , and amperometric ) detection.", "output": [ "background" ] }, { "id": "task1163-2fe10621c5b343c0a3c6acd6ae20580c", "input": "West Nile fever , SARS , and MERS.", "output": [ "purpose" ] }, { "id": "task1163-d8f0389eee714bff9509d660b253d991", "input": "In this study , we discovered that theaflavin showed the lower idock score ( idock score : − 7.95 kcal/mol ).", "output": [ "finding" ] }, { "id": "task1163-94563b71645a4208ba57ec8795d1251c", "input": "Materials and Methods : A total of 38 Sequences of Cryptococcus neoformans var.", "output": [ "method" ] }, { "id": "task1163-3a315f5e95a3408db629358d649ad2ff", "input": "the patient experienced cardiac arrest.", "output": [ "finding" ] }, { "id": "task1163-1063f09892cb49f6a36f680b3aa57658", "input": "six cynomolgus macaques ( Macaca fascicularis ) were inoculated with hMPV and examined by pathological and virological assays.", "output": [ "method" ] }, { "id": "task1163-36c69d5682ff44f7a8ac682f600a5017", "input": "the Philippines , and Thailand.", "output": [ "background" ] }, { "id": "task1163-7a044b22ec07491d84783f4f49051393", "input": "highlighting the need for future research to more clearly define the biological function ( s ) of this potentially important co-chaperone.", "output": [ "purpose" ] }, { "id": "task1163-90b8d5a8890a4acb85ccba7168f7dde3", "input": "MERS and SARS , as approximations for the true unknown SI.", "output": [ "method" ] }, { "id": "task1163-5a072492c8b540d586439a2ea01e0c6e", "input": "but had not been previously tested on the RV16 or xTAG.", "output": [ "method" ] }, { "id": "task1163-93d15f5ec3f2454eafac8ffccc85f90e", "input": "suitable for a clinical readership without specialist airflow or engineering knowledge.", "output": [ "purpose" ] }, { "id": "task1163-eea5539fb4f4469dbb8030535936597b", "input": "It also remains to be determined whether E palmitoylation or disulfide bond formation plays a role in SARS-CoV virus assembly.", "output": [ "background" ] }, { "id": "task1163-8b2679a455f645cc9cfc44261867dac5", "input": "Here , we review the most recent findings on the molecular pathogenesis and the interaction of CCHFV with the type I interferon and cytokine responses and discuss implications for pathogenesis.", "output": [ "purpose" ] }, { "id": "task1163-dd8257a1a320473d95cc5c8919a4b06b", "input": "Oligonucleotide primers were designed based on conserved avian S3 nucleotide sequence data.", "output": [ "method" ] }, { "id": "task1163-3898fe49c40347749c874ce6da637071", "input": "we used the immunoinformatics approach to design a potential epitope-based vaccine against the RNA-dependent RNA polymerase-L of EBOV.", "output": [ "method" ] }, { "id": "task1163-295bdba961e04a169982370dad20bf9a", "input": "We used two strategies for SARS-CoV-2 testing : targeted testing of high-risk individuals ( n = 4,551 ) and a population screening ( n = 5,502 ).", "output": [ "method" ] }, { "id": "task1163-02fceb7724dd4e3f8e31dddfb06c3904", "input": "have incurred significant morbidity and mortality.", "output": [ "background" ] }, { "id": "task1163-a548995af05a49e38b47d00ea97842d9", "input": "and bacteriochlorophyll ( 16 ).", "output": [ "finding" ] }, { "id": "task1163-e9dfc42c0d0b4471b6f14746d29db832", "input": "In the current review , we first describe the molecular and genetic characteristics of the PEDV.", "output": [ "purpose" ] }, { "id": "task1163-4be565de495f471c92039d63534f43a7", "input": "We show that the amount and the peculiarities of distribution of the protein intrinsic disorder in the viral shell can be used for the efficient analysis of the behavior and transmission modes of CoV.", "output": [ "purpose" ] }, { "id": "task1163-9cddd82967e5448480ae87542ca1391f", "input": "Key stakeholder perspectives were sought of the managerial processes associated with perceived success and lessons for future outbreaks.", "output": [ "purpose" ] }, { "id": "task1163-944f22822d844259b5d5ee87e1aa6736", "input": "Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N , an anti-HIV antibody.", "output": [ "finding" ] }, { "id": "task1163-dfc3d0982abf43ee89907bcb8568e406", "input": "These results suggest that this assay offers a reliable method to detect HCoV-OC43 infection and may be a useful tool in coronavirus seroepidemiological studies.", "output": [ "finding" ] }, { "id": "task1163-311270319071438ea0ec8f3a1e1a59dc", "input": "has rapidly spread to almost all parts of world.", "output": [ "background" ] }, { "id": "task1163-c6a06062f59b43238bdf8eddfaf34391", "input": "poultry diseases , and fish diseases.", "output": [ "finding" ] }, { "id": "task1163-94abcf1ffffc4ed68662950f56ec07f6", "input": "In this study , we aimed to shed greater light on early steps in IBV infection.", "output": [ "purpose" ] }, { "id": "task1163-47c7a1676b07493a968ac65239d35352", "input": "Multiple sequence alignment was performed by using Clustal X ( version 2.0.11 ) with 44 human-derived ( including the Malaysian case ; MyH010414 ; GenBank accession No : KP769415 ) and 3 camel-derived MERS-CoV sequences ( 6 ).", "output": [ "method" ] }, { "id": "task1163-7b36d62c074942a88cb1383b432a8249", "input": "and Chikungunya virus ( CHIKV ).", "output": [ "background" ] }, { "id": "task1163-53ab4bd4d0504df79edf11a68f85295b", "input": "We present the sequence of an open reading frame ( ORF ) at the 3 ' end of human astrovirus serotype 1.", "output": [ "purpose" ] }, { "id": "task1163-ade0084d48b24f649a03e9b6d9d5b33e", "input": "especially in individuals with underlying comorbidities.", "output": [ "background" ] }, { "id": "task1163-21bd77f11b8a4f238106d11329f905c2", "input": "We report an auto-induction methodology that provides soluble-cruzain at high yields ( > 30 mg per liter in minimal media ).", "output": [ "background" ] }, { "id": "task1163-401c578016184ed99d758e0e9676dc99", "input": "Methods We conducted a cross-sectional study using stored samples of an influenza-like illness surveillance program.", "output": [ "method" ] }, { "id": "task1163-d2b9c95d31cc4609b3cc6131a95b44f1", "input": "as no intermediate cleavage products covering the proteinase were detected in either IBV-infected or transfected cells.", "output": [ "finding" ] }, { "id": "task1163-38881f258f5b4ba5a62ed5bf34b85619", "input": "addressing these as the communication of risk and subsequent risk management.", "output": [ "purpose" ] }, { "id": "task1163-2cfc3cadec904b4b8c6252f7a3fdd2aa", "input": "We describe the pulmonary pathology of patients who died in the 2003 Toronto outbreak.", "output": [ "purpose" ] }, { "id": "task1163-2263093f56a04a4583dc76218270a780", "input": "The pluripotency markers SSEA4 and TRA-1-81 were not detectable in iPSC-nCoVN.", "output": [ "background" ] }, { "id": "task1163-f293e0deeae14dbd9424a93564fd6123", "input": "Results : The final database included 1187 articles published between 1905 and 2006.", "output": [ "finding" ] }, { "id": "task1163-0171ed14b6a744ff82efad461ab9236d", "input": "We included 61 studies ( 56 examining impact on mental health and five about interventions to reduce such impact ).", "output": [ "method" ] }, { "id": "task1163-5f644065720b4f7685aa3f0538a05853", "input": "the vaccine candidates against uropathogenic Escherichia coli ( UPEC ) were predicted using Vaxign and compared with various experimental studies.", "output": [ "method" ] }, { "id": "task1163-d8fd5b08e02d4025aa04ae398b44f54c", "input": "which was chosen as an adjuvant because of its long history of safety for human use.", "output": [ "method" ] }, { "id": "task1163-11de04393c1c432ab57475f332f36fce", "input": "which faces the cytosol during and after opening of the fusion pore at early stages of the virus life cycle.", "output": [ "method" ] }, { "id": "task1163-33e047191899479db842cf508404664c", "input": "targeting N pro , NS3 and NS5B genes of CSFV.", "output": [ "method" ] }, { "id": "task1163-5c6a58e8b9ee4d6999b503fcfe2d950a", "input": "agree with observations regarding the ability of animal viruses to infect humans.", "output": [ "method" ] }, { "id": "task1163-b371301f79b54591a5e47779659bc3c1", "input": "Pneumoviruses have been identified as causative agents in several respiratory disease outbreaks in habituated wild great apes.", "output": [ "background" ] }, { "id": "task1163-567902f01a4d42db975df28190fe74bc", "input": "the presumed peplomeric protein , that was glycosylated and proteolytically cleavable by trypsin into subunits of 110 and 90 kDa.", "output": [ "finding" ] }, { "id": "task1163-486b8756c2a54da9a2375a16a5ee0844", "input": "This study aimed.to look for enterotoxic effect elaborated by Cryptosporidium.", "output": [ "purpose" ] }, { "id": "task1163-f2417e6318af48d895449451bd3feeae", "input": "The in silico analysis predicted that this quinone could bind to the prefusion form of the E glycoprotein of DENV-2.", "output": [ "finding" ] }, { "id": "task1163-55ed0ee1528143708441baad4f5053ef", "input": "and an image-based high-content assay to identify and characterize inhibitors of CHIKV-infection in vitro.", "output": [ "purpose" ] }, { "id": "task1163-38e863dddbbc42b6a66983cb972697eb", "input": "Tanzania , between 2013 and 2015.", "output": [ "method" ] }, { "id": "task1163-f8fce9a282bb4790aa3b9f97cb5088e3", "input": "crystallization , enzymatic characterization , and structure determination.", "output": [ "purpose" ] }, { "id": "task1163-8ff8e1b0ed504675bd70f88c5393c4e1", "input": "which has become a social science concept ( 15 ) and is being applied in disaster management.", "output": [ "background" ] }, { "id": "task1163-9109ac36473641559d9c6d5cc0ea3e94", "input": "In this study , several monoclonal antibodies against the nucleocapsid protein have been generated to examine distribution of the nucleocapsid in virus-infected cells and to study antigenic regions of the protein.", "output": [ "purpose" ] }, { "id": "task1163-7cc53490cf3d4dce88cacded420f2e7c", "input": "especially in regard to the existence of monocyte-derived microglia.", "output": [ "background" ] }, { "id": "task1163-f988fcac14fa492793aa35f79a29df0e", "input": "in order to disentangle the variability arising from the experimental compared to the bioinformatics parts of the laboratory pipeline.", "output": [ "method" ] }, { "id": "task1163-38a6bd2f3e2e4e6eb605fdf079d4c4b7", "input": "The objective of this study was to assess the level of preparedness of emergency infection control measures in Japan and to quantify the differences in preparedness across institutions and disciplines.", "output": [ "purpose" ] }, { "id": "task1163-4c9dbcae4f634ca9a39653b44427e546", "input": "Yennawar M , et al. ( 2018 ) A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus.", "output": [ "background" ] }, { "id": "task1163-be5fb53d091a4ee49d670f300c5f6bfc", "input": "protect D-GalN-treated mice from lethal shock induced by TLR9 agonist , not by TLR3/4 agonist.", "output": [ "finding" ] }, { "id": "task1163-cdbccb9afa8f49cf9b64bbc08dcfa1a3", "input": "and histopathologic findings were evaluated.", "output": [ "method" ] }, { "id": "task1163-756efa15d21b40bda32676a36834d21b", "input": "Here we assess support for this hypothesis using direct evidence : the fitness effects of mutations in actual proteins measured via individual or paired growth experiments.", "output": [ "purpose" ] }, { "id": "task1163-9c01281d4d1940c6912dcedcb928c59e", "input": "Epidemiology supports a relationship of KD to an infectious disease.", "output": [ "background" ] }, { "id": "task1163-da43f650e1f84574876c0e59cd186bc8", "input": "In this paper , a novel stochastic model is proposed which aims to account for the unique transmission dynamics of COVID-19 and capture the effects of intervention measures implemented in Mainland China.", "output": [ "purpose" ] }, { "id": "task1163-1f80c2146d7c438a989611350b6296f8", "input": "implying that these residues might contribute differently to the dimer stability.", "output": [ "finding" ] }, { "id": "task1163-c7f0d8efd90b4855b7bd0f3d84b56dfe", "input": "And fourth , rotavirus can prevent STAT1 and STAT2 nuclear translocation.", "output": [ "background" ] }, { "id": "task1163-519111067347411e9902601d02bcdf3c", "input": "Serologic testing was done for 53 ( 75 % ) of 71 nonsymptomatic contacts ; all results were negative.", "output": [ "finding" ] }, { "id": "task1163-52733f6589f045f08f66972d366b0a5b", "input": "This formative research explored community perceptions about respiratory infections.", "output": [ "purpose" ] }, { "id": "task1163-541bd09b1eb64cc4a52ebc01c3dd552f", "input": "Rolling circle amplification using DNA from harderian and parotid glands identified a novel 5.1-kb polyomavirus genome closely related to human Washington University ( WU ) and Karolinska Institute ( KI ) and vole polyomaviruses but notably divergent from Rattus norvegicus PyV1 ( RnorPyV1 ; also designated RatPyV1 ).", "output": [ "finding" ] }, { "id": "task1163-8846d5f8d5664f23b558718d7b048c9e", "input": "Ang-1-7 AT 1 G B M Figure 1 | The podocyte renin - angiotensin system and the mechanisms by which increased ACE2 expression can decrease local angiotensin II production.", "output": [ "background" ] }, { "id": "task1163-331542b3d9e3418eb3694a656f3869e4", "input": "• Using multiple-scale analysis , we present amplitude equations.", "output": [ "method" ] }, { "id": "task1163-9f757be022f447bcbcc7865545d7aba5", "input": "be applicable to Aβ and other amyloidogenic systems.", "output": [ "finding" ] }, { "id": "task1163-af37092d80f040dca2cf162e5cce4a7d", "input": "We identified 110 healthcare workers with exposure within droplet range ( i.e. , 3 feet ) to six SARS-CoV-positive patients.", "output": [ "finding" ] }, { "id": "task1163-57549b95a89f4add8b57c60f88387580", "input": "fluorescence enhancement , and quenching caused by plasmon and colorimetry changes based on the coupling of GNPs.", "output": [ "method" ] }, { "id": "task1163-f6551ac5087d44ee9b47500dad9e8cb1", "input": "In this review , we summarize what is currently known about the interplay between autophagy and HCV and the possible mechanisms whereby autophagy proteins might favor HCV propagation.", "output": [ "purpose" ] }, { "id": "task1163-ac7edd2df79549e088cf9d75d25a78a5", "input": "the paraventricular and supraoptic nuclei.", "output": [ "background" ] }, { "id": "task1163-ae675766baee4a56918a0b8047e2b4b7", "input": "2014 , with most cases detected in September.", "output": [ "finding" ] }, { "id": "task1163-bd60e3a081f54bf9b9b00c9f1b125c63", "input": "We are now using N63Y mutant CVB3 as an improved system for viral pathogenesis studies.", "output": [ "finding" ] }, { "id": "task1163-16c69f94aca8445990e5cf2b6f799c2f", "input": "A third group of five uninfected animals was used as control.", "output": [ "method" ] }, { "id": "task1163-e47f4b755e8e4f88bbe48c570f47a559", "input": "Wild-type CVB3 and N63Y mutant CVB3 had similar plaque sizes when agarose was used in the overlay instead of agar.", "output": [ "finding" ] }, { "id": "task1163-7c4b58103d594242a44a590f82eaa9ac", "input": "We aimed to investigate the administered medications and intervention times for patients who completely recovered from COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-c4ee9a030c7848cebcebaf8c85799352", "input": "For this purpose , 5-bromo-2deoxyuridine ( BrdU ) labeling was chosen because of its sensitivity and the possibility of further characterization of proliferating cells.", "output": [ "method" ] }, { "id": "task1163-d857ca010c434cf786700d1a4387475e", "input": "At the same time , nasal samples were obtained from the 15 health care workers who had participated in the resuscitation.", "output": [ "finding" ] }, { "id": "task1163-03c27ea4e462460c887090343db02a03", "input": "This becomes an issue for the development of vaccine and treatment options where characterizing the type of immune response generated is critical for understanding protection from disease.", "output": [ "background" ] }, { "id": "task1163-852cfd92def04d27b3c8be84970b258d", "input": "Silver nanomaterials ( Ag NMs ) have attracted great interests in recent years due to their excellent anti-microorganism properties.", "output": [ "background" ] }, { "id": "task1163-057083c7f6924bd48c3cb305312b5984", "input": "and full-length cDNA clones possessed all characteristic class Ia exons.", "output": [ "method" ] }, { "id": "task1163-9453c2accee24293ba4c57f51c7b5de8", "input": "Our findings suggest that RatPyV2 may be a commensal infection of laboratory rats that can lead to disseminated disease in T cell immune-deficient rats.", "output": [ "finding" ] }, { "id": "task1163-5f6f54833dcb46e388b1f6da5c7d0228", "input": "It has long been held that initial neuroantigen presentation and T cell activation events occur in the immune periphery and then translocate to the CNS.", "output": [ "background" ] }, { "id": "task1163-a369e8df5c2b479a89c0938f2863e5ca", "input": "probably reflecting a general regulating mechanism.", "output": [ "finding" ] }, { "id": "task1163-7b7f5c7b38ab44e58f636087acaa2f2f", "input": "Here , we analyzed the N-glycosylation of the receptor-binding domain ( RBD ) of IBV strain M41 spike protein and assessed the role of this modification in host receptor binding.", "output": [ "method" ] }, { "id": "task1163-7b81aa75e0ea41f9abcdf6eb32a3a1c7", "input": "In this study , we evaluated the replication and pathogenicity of all nine APMV serotypes in hamsters.", "output": [ "purpose" ] }, { "id": "task1163-1534455d69404b009bc4282d5a9fabd9", "input": "In this study , the two diagnostic assays that targeted respectively on Mp-antibody and Mp-DNA were retrospectively investigated.", "output": [ "purpose" ] }, { "id": "task1163-a0671c472e0e4701853fd86e15b4ddba", "input": "two major caveolar coat proteins , in rat tracheal epithelium.", "output": [ "method" ] }, { "id": "task1163-dcabd75103b743f8b58b827539b996d6", "input": "especially enterotoxigenic E. coli ( ETEC ) , in diarrheic calves.", "output": [ "purpose" ] }, { "id": "task1163-2f642b82804c4c939e97e9ed4f4de64a", "input": "We also assumed that individuals who choose to visit a location ( an indoor environment for a fixed duration ) come at the same time and leave at the same time.", "output": [ "method" ] }, { "id": "task1163-1e0af492ae8f4b368f3465e77313ab85", "input": "6 weeks after the infection.", "output": [ "finding" ] }, { "id": "task1163-c4a916b7f2414c33965ebebc920b8645", "input": "Anti-HSV DAAs acyclovir and foscarnet offer examples of the hazards of drug resistance.", "output": [ "background" ] }, { "id": "task1163-363c398fa10945c3bab5a201c88a7b87", "input": "target cell types and efficiency of RNAi in the mouse seminiferous epithelium.", "output": [ "purpose" ] }, { "id": "task1163-c0e50b1381f3431087da779d2a56688f", "input": "and were not durably protected by BCG vaccination.", "output": [ "method" ] }, { "id": "task1163-0e9e26eea1ec415db15fdd15c43fec3a", "input": "Although the calves were shedding BCoV RNA 21 days after infection the sentinel animals were not infected.", "output": [ "finding" ] }, { "id": "task1163-462cfae1512e456eaf5a729b1d19caa3", "input": "while viral infection was assessed by real-time RT-PCR in faeces.", "output": [ "method" ] }, { "id": "task1163-1d811eca039e438ba441da9c66b1b071", "input": "Pulmonary alveolar proteinosis ( PAP ) is characterized by accumulation of a surfactant-like substance in alveolar spaces and hypoxemic respiratory failure.", "output": [ "background" ] }, { "id": "task1163-f82a16705a0d438a8f2445690de1e4d3", "input": "and the ways in which the outbreak had affected their mental health.", "output": [ "method" ] }, { "id": "task1163-ab994d9d30344af8b2c7cae7ae899331", "input": "and tested it against a catalytically deficient mutant HAV 3C pro and other virus-encoded proteases.", "output": [ "method" ] }, { "id": "task1163-15f956daf8e64f5ca78b50f4946a1218", "input": "147 , 200 and 545 were additionally present in QX-like strains.", "output": [ "finding" ] }, { "id": "task1163-f8157d5aecf34dfaa9566f071892f635", "input": "Therefore , a better understanding of the immune-related molecular processes in virus-induced autoimmunity is warranted.", "output": [ "purpose" ] }, { "id": "task1163-6e78ffa2985d4caf88ea15e36e0e0601", "input": "Ophthalmic practices took similar preventive measures ( frequent hand washing with the use of chlorhexidine alcoholic handrub ; wearing surgical/N95 respirator masks , as well as gloves and water-resistant gowns and visors ) to prevent contracting or spreading the SARS infection ( 9 ).", "output": [ "background" ] }, { "id": "task1163-54ba882401fe46fda575151e2d8334aa", "input": "Rotavirus , and Picobirnavirus from fecal samples of pre-weaned piglets in Northeast region of India.", "output": [ "purpose" ] }, { "id": "task1163-132022747c0d4413bd73082547d63ca6", "input": "have become a top global priority.", "output": [ "background" ] }, { "id": "task1163-fb5dcc806dbf4111852a33886f1111ff", "input": "their travel itinerary ( including detailed information about all countries or regions visited ) , and clinical manifestations.", "output": [ "method" ] }, { "id": "task1163-aaae96dabfa84e78b832bf53e98c102c", "input": "In this study , we report the complete coding genome sequences of six FCoVs : three from faecal samples from healthy cats and three from tissue lesion samples from cats with confirmed FIP.", "output": [ "purpose" ] }, { "id": "task1163-5d503d477b154f2fa563138ecf7ec3e8", "input": "The changes consisted of perivascular cuffing by mononuclear cells and neuronal damage.", "output": [ "finding" ] }, { "id": "task1163-8fa72f46d73f4492af280992380884fa", "input": "Furthermore , vaccination of animals is proving to be effective in reducing transmission to humans.", "output": [ "background" ] }, { "id": "task1163-72189d799d7e4658a0761630410d67d1", "input": "obtained from medical records , focusing on the diagnostic performance for definite PTB.", "output": [ "method" ] }, { "id": "task1163-312bbc7f4f2f4d26b6b2de5ffed20604", "input": "Surprisingly every day risk is different from the generally expected potential risk according to traditional ranking of hazards ( zoonoses ) in dogs in general.", "output": [ "background" ] }, { "id": "task1163-549322df985446eaaf3db8a997b89067", "input": "selective pressures , and its codon adaptation to human genes are assessed.", "output": [ "method" ] }, { "id": "task1163-cdb53221bcb14866ab4cb7538533d8cd", "input": "who are interested in MCE and want to adopt MCE as a functional unit in their integrated microsystems.", "output": [ "purpose" ] }, { "id": "task1163-7d347d8e7b3b482fa5808f0c361d252e", "input": "In this article , we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus.", "output": [ "purpose" ] }, { "id": "task1163-8eeaca9b85894a60aada56f7998ab91b", "input": "He worked as a pipe fitter.", "output": [ "background" ] }, { "id": "task1163-0d136b4e82694320b52356dedb6e4265", "input": "Most studies with coxsackieviruses and other viruses use laboratory-adapted viral strains because of their efficient replication in cell culture.", "output": [ "background" ] }, { "id": "task1163-4303ccd4f7f248dda3ec70e5b9be7161", "input": "Background : The nasal avian schistosome Trichobilharzia regenti spends part of its intravertebrate period of life within the central nervous system.", "output": [ "background" ] }, { "id": "task1163-64354f0a6c0844efba8e0d0412faf332", "input": "In the present report we have compared the CNS lesions induced by JHMV in lethally infected and T cell clone protected mice.", "output": [ "purpose" ] }, { "id": "task1163-3034af0aef634e2f94dc5623b3183bf5", "input": "inhibited virus fusion from the avirulent NDV strain when added before the cleavage of the fusion protein.", "output": [ "finding" ] }, { "id": "task1163-cb3c7800965242e79120f15eeacb415d", "input": "sitewise gradient of amino acid diversity.", "output": [ "purpose" ] }, { "id": "task1163-683ffce0049b44a08a839136c4d7288b", "input": "However , an increasing body of evidence suggests that antigen ( Ag ) presentation might initiate within the CNS itself.", "output": [ "background" ] }, { "id": "task1163-7580b27100e14c6383a07656b6123d5f", "input": "up to two courses of RBV.", "output": [ "method" ] }, { "id": "task1163-8f765435d50b47308bd7d7905d7481d3", "input": "and we hypothesized that anti-cat isotype-specific antibodies would cross react with hyena immunoglobulin epitopes.", "output": [ "purpose" ] }, { "id": "task1163-3b0e5b15565d476d8d9b920f214c2dc0", "input": "and only an attenuated influenza virus vaccine uses the nasal route.", "output": [ "background" ] }, { "id": "task1163-e50e59b609404447befaca9484e55c35", "input": "This paper discusses the issue of selecting the design solution that best accords with an articulated preference of multiple criteria with an acceptable performance band.", "output": [ "purpose" ] }, { "id": "task1163-f809f9d3faa54385af62c1d8c3101e51", "input": "while only 2/9 WT mice showed similar graft consolidation.", "output": [ "finding" ] }, { "id": "task1163-a36176410ab94734a4e6c25eb00752bb", "input": "The presence of two distinct membrane topologies of the SARS-CoV E protein may provide a useful clue to the pathogenesis of SARS-CoV.", "output": [ "finding" ] }, { "id": "task1163-97ea51d253f54f38918a383a54f61bb6", "input": "The need for novel therapeutic options to fight herpesvirus infections still persists.", "output": [ "background" ] }, { "id": "task1163-a3c0d878fade492c8bfea2486278ba35", "input": "and hamsters ( Clostridium difficile ).", "output": [ "purpose" ] }, { "id": "task1163-d360a849f8d8409c8264084717ad3c21", "input": "The specificity of intra-and inter-species hybrids was maintained by subcloning.", "output": [ "method" ] }, { "id": "task1163-4a8c014971534099b995562bf1016477", "input": "two kinds of silver nanowires ( XFJ011 ) and silver colloids ( XFJ04 ) were selected to study their inhibitory effect on TGEVinduced host cell infection in vitro.", "output": [ "background" ] }, { "id": "task1163-15cdd67902e64d12a0424ea81a5f1dd8", "input": "and to investigate their association with clinical manifestations of systemic sclerosis ( SSc ).", "output": [ "purpose" ] }, { "id": "task1163-37453afdb4cd4f508ba84921c31a140a", "input": "This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.", "output": [ "purpose" ] }, { "id": "task1163-eb7563a1eb624032b4c67d81fce2666b", "input": "Shading mask is typically used to assess availability of daylight outside a residential unit and hence is an ideal parameter for assessing view obstruction.", "output": [ "background" ] }, { "id": "task1163-e2a5c87e4f9945d985a10b948a35be6d", "input": "Coronavirus disease-2019 ( COVID-19 ) is a rapidly escalating epidemic caused by SARS-CoV-2.", "output": [ "background" ] }, { "id": "task1163-ba0d6e6bbfd2403f9443f466b64fbff8", "input": "We apply this method to quantify the similarity of different stock markets.", "output": [ "method" ] }, { "id": "task1163-29f0a2dbc1654da88f1f4387b066f9ff", "input": "myalgias , and mild hypertension.", "output": [ "purpose" ] }, { "id": "task1163-3f57d06b6c974e9ea3a0ff7200153670", "input": "while the AM strain showed more infectivity in the cerebellum in neonatal ddY mice.", "output": [ "finding" ] }, { "id": "task1163-7029fa314e96495db15704db7959e798", "input": "29 ( 40.85 % ) were found to be positive by PCR assay.", "output": [ "finding" ] }, { "id": "task1163-8ef5cf1b23984d7d973674c4133b2a1d", "input": "These models are employed to evaluate the effectiveness of various control programs via vaccination and antiviral treatment.", "output": [ "background" ] }, { "id": "task1163-e93f2bd866204247be4112c17e756a23", "input": "Iowa , North Carolina , Nebraska and Illinois.", "output": [ "purpose" ] }, { "id": "task1163-b537fe479c36464ba83a8330106b571f", "input": "Here we describe the use of transient dominant selection as a method for introducing modifications into the IBV cDNA.", "output": [ "purpose" ] }, { "id": "task1163-73f24a392a4f458e934935a5d139cec0", "input": "inflammasome activation , and modulation of lipid signaling networks.", "output": [ "purpose" ] }, { "id": "task1163-82656bb63de342f28b7db7a954f22767", "input": "which contribute to allergy , fibrosis , and granuloma formation.", "output": [ "background" ] }, { "id": "task1163-3b2e3dd9b200486f971380646ed544eb", "input": "We now report our experiences in the fusion of both long term cultures of rat T cell clones and mouse T cell lines to rat W/Fu ( C58NT ) D. Upon fusion of rat T cell clones the hybrids obtained expressed antigen specificities identical to those of the parent clones.", "output": [ "background" ] }, { "id": "task1163-11250d12067f401b9f77c96b66fa248c", "input": "a high-fidelity patient simulator study with 40 HCP as participants evaluated the gown redesign using 2 commonly performed tasks.", "output": [ "method" ] }, { "id": "task1163-2aef3299226247a1a070c3ac0146c607", "input": "P-value < 0.001 ) and diabetes ( AOR = 1.68 ; 95 % CI ( 1.346-1.848 ) , P-value = 0.002.", "output": [ "finding" ] }, { "id": "task1163-e157009196f94343854bad5efc9e680c", "input": "GTases catalyze a two-step reaction in which they initially utilize GTP as a substrate to form a covalent enzyme-GMP intermediate.", "output": [ "background" ] }, { "id": "task1163-e5970d5b2a964bb181fa0544e4858032", "input": "But the potential value of such restrictions has not been quantified.", "output": [ "background" ] }, { "id": "task1163-35012d6ebc644c469f30fba6808f93f4", "input": "We searched Medline and EMBASE for studies evaluating these tests against polymerase chain reaction as the reference standard.", "output": [ "method" ] }, { "id": "task1163-6a3c3ae7a5a846e58fc602f5dde32ffc", "input": "Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment.", "output": [ "background" ] }, { "id": "task1163-bc3bc4348cac4d3996b3b6f367a10e9b", "input": "We also report a full-length NSP4 gene sequence of human RVC from India.", "output": [ "finding" ] }, { "id": "task1163-4a02852f52474103b7a13b9c77ae3a6a", "input": "oligodendroglial cell death and downregulation of myelin genes start days after initiation of the cuprizone diet and weeks before demyelination is obvious.", "output": [ "purpose" ] }, { "id": "task1163-f54975104527492c9bafdc280c79c58a", "input": "Streptococcus mutans , Cryptosporidium parvum and Helicobacter pylori.", "output": [ "background" ] }, { "id": "task1163-3c11f7fd08db412193605753d522c249", "input": "It is released from the 1a and 1a/1b polyproteins by autoprocessing at two Q-S dipeptide bonds ( Q 2779 - S 2780 and Q 3086 - S 3087 ).", "output": [ "background" ] }, { "id": "task1163-d0cc5ca4e3734f109bdfa4f25e88f488", "input": "The goal of this study was to define the role of the classical complement activation pathway in the progression of pathology in the 3xTg mouse that develops tangles in addition to fibrillar plaques ( more closely reflecting human AD pathology ) and to assess the influence of complement in a model of AD with a higher level of complement hemolytic activity.", "output": [ "purpose" ] }, { "id": "task1163-a4065f10898a4abba4aed7597ed4c7ac", "input": "the fusion ( F ) glycoprotein which transits from a metastable pre-fusion conformation to a highly stable post-fusion structure during the membrane fusion process.", "output": [ "background" ] }, { "id": "task1163-fb5fbbe7cdc1456ab53470cb35ea8a11", "input": "We used a quencher to reduce nonspecific amplification.", "output": [ "method" ] }, { "id": "task1163-780279e68acc40bfb58ba7b734c351a3", "input": "In this study , we report a NGS library preparation method to identify RNA viruses using the Ion Torrent PGM platform.", "output": [ "purpose" ] }, { "id": "task1163-8b380575d4a54d10a25088bd295fe770", "input": "consistent with known patterns for seasonal influenza.", "output": [ "method" ] }, { "id": "task1163-d229bd5311264ea994f522944bd1faea", "input": "we characterized the 5 ¢ termini of the genome and the four sg mRNAs of Berne virus ( BEV ).", "output": [ "method" ] }, { "id": "task1163-6e2565515a4f49e4bd22c32e46f1c4cf", "input": "can modulate the extent of IFN responses and the susceptibility to infections.", "output": [ "background" ] }, { "id": "task1163-40831eef91bb48b0adccc0f5ba5f7804", "input": "including physicians , should contribute equally in zoonoses prevention programs ( ` One health ' approach ).", "output": [ "finding" ] }, { "id": "task1163-724f142b11fa40e4b313760f94502bff", "input": "In addition , several accessory ORFs are also interspersed along the structural protein genes and the number and location varies among CoV species ( 25 ) ( Figure 1 ).", "output": [ "background" ] }, { "id": "task1163-77acec8ed2cb4858898c1589677d5821", "input": "we estimate IFR and CFR in China to be 0.5 % ( 95 % CI : 0.2-1.2 % ) and 1.1 % ( 95 % CI : 0.3-2.4 % ) respectively.", "output": [ "finding" ] }, { "id": "task1163-7ed89afe34c842c7a68f3a5c160d8912", "input": "Methods : The effects on human intestinal transport of stool supematant of diarrheal calves infected with Cryptosporidium parvum were examined.", "output": [ "method" ] }, { "id": "task1163-9d680c1fbfc24a6eaabbb00979109436", "input": "The basic reproduction number R 0 is one of the most important concepts in modern infectious disease epidemiology.", "output": [ "background" ] }, { "id": "task1163-6941ff3ad6c74599b19c5b734ba6e708", "input": "highly pathogenic , zoonotic paramyxoviruses that belong to the genus Henipavirus.", "output": [ "background" ] }, { "id": "task1163-124da8db8e9d4e259f5f4ada2653263d", "input": "We hypothesized that invasive pulmonary aspergillosis ( IPA ) may generate a distinctive proteomic signature in plasma and bronchoalveolar lavage ( BAL ).", "output": [ "purpose" ] }, { "id": "task1163-8a572e57799a46a3897ff9320c68f1f4", "input": "Insertion of the foreign gene at the 3 rd position had a minimal impact on viral replication in vitro.", "output": [ "method" ] }, { "id": "task1163-5db68a162ea644d2adcb068d1ef577c6", "input": "In addition , patients who died during hospitalization had significantly higher medical costs ( 6421 versus 5825 US Dollars , P < 0.001 ) and shorter lengths of stay ( 13 versus 19 days , P < 0.001 ) than patients who survived.", "output": [ "finding" ] }, { "id": "task1163-5f5c43cef28442e7b2e086a994f91eeb", "input": "from unicellular organisms to vertebrate neurons.", "output": [ "background" ] }, { "id": "task1163-464989b2b20649148489dee6c1449f46", "input": "In brief , 5 L of virus RNA and 5 L of random primers ( 100 µmol/L ) in a total reaction volume of 22 L were incubated at 70 C for 15 min and at 4 C for 5 minutes.", "output": [ "method" ] }, { "id": "task1163-4b44a6863a87483b80d40d3566f820cd", "input": "microscopy , serology and molecular biology.", "output": [ "method" ] }, { "id": "task1163-8081e6d2836e4d00ba654fef24f43458", "input": "This paper explores computational solutions for building phylogeny of species along with highlighting benefits of alignment-free methods of phylogenetics.", "output": [ "purpose" ] }, { "id": "task1163-8cab6d7529b04fd8829b7e74c4c06ffa", "input": "Please cite this paper as : Salmó n-Mulanovich et al. ( 2011 ) Frequency of human bocavirus ( HBoV ) infection among children with febrile respiratory symptoms in Argentina , Nicaragua and Peru.", "output": [ "finding" ] }, { "id": "task1163-82226e4d50744d4bb308681971018cfb", "input": "Patients who died during hospitalization were older ( 69 AE 17 versus 62 AE 19 , P < 0.001 ) and predominantly male ( 69.8 % versus 65.3 % , P < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-0e081a7d792e49a0a60e971a5ed65299", "input": "in particular , those against emerging infectious diseases.", "output": [ "purpose" ] }, { "id": "task1163-5ffe62e366ac4eef925f1086b429c86e", "input": "A sample of 227 mostly primiparous women in the third trimester of pregnancy was surveyed in a large tertiary care hospital in Beijing , China.", "output": [ "method" ] }, { "id": "task1163-eabbb8f2f03942ed931ef009c2e78041", "input": "and produces a possibly pseudoknotted structure whose energy is at least as low as that of any ( density-2 ) pseudoknotted structure containing the input structure.", "output": [ "method" ] }, { "id": "task1163-18ee6a8c3cae40148005813a5ccfed7a", "input": "and will serve as an example of how such assignments can be developed or extended on other systems of interest.", "output": [ "purpose" ] }, { "id": "task1163-f4f9895a54ae4b23af4c4771b617868b", "input": "We describe a new technology for the molecular genotyping of microbes using a platform known commercially as the Ibis T5000.", "output": [ "purpose" ] }, { "id": "task1163-635a19e3f9fe4f55b5f8a82f61bc472f", "input": "laboratory , clinical and outcome characteristics in relation to various etiologies of this syndrome.", "output": [ "purpose" ] }, { "id": "task1163-5e44297d96d94ef1832d0a2e15989d95", "input": "Our objective is to describe the clinical characteristics of SARS-CoV-2 pneumonia compared to normal controls in the Chinese Han population.", "output": [ "purpose" ] }, { "id": "task1163-607eefa853364c4d874a8bb543dd1c8f", "input": "The eosinophils presented peaks in four periods after infection.", "output": [ "finding" ] }, { "id": "task1163-f20e0c9920884e989db1308423dcdd45", "input": "Human intestinal maltase ( HMA ) is an αglucosidase responsible for the hydrolysis of α-1,4-linkages from the non-reducing end of malto-oligosaccharides.", "output": [ "background" ] }, { "id": "task1163-4c67422cc1734906b7ea8c2424641f0e", "input": "orientation , planning , and outcomes of international social work student exchanges.", "output": [ "purpose" ] }, { "id": "task1163-02f9d43cf00346cc9093a61b868bba2d", "input": "or a combination of ground-glass opacities and consolidation ( 58 % ).", "output": [ "finding" ] }, { "id": "task1163-953ae56cf0264f178339f9e58bc1504c", "input": "was isolated in turkey embryo kidney cells and RNA was purified for cDNA synthesis.", "output": [ "method" ] }, { "id": "task1163-e0efa04634944e2da39330c988489dd0", "input": "We present what may be the simplest possible reliable gene network oscillator , a self-repressing gene.", "output": [ "finding" ] }, { "id": "task1163-8d4c05daf08845538f090f20e7197834", "input": "Here we describe the epidemiological pattern for these respiratory viruses detected by DFA in 10 ' 629 nasopharyngeal aspirates collected from 8 ' 285 patients during a 12-year period ( 1998 ) ( 1999 ) ( 2000 ) ( 2001 ) ( 2002 ) ( 2003 ) ( 2004 ) ( 2005 ) ( 2006 ) ( 2007 ) ( 2008 ) ( 2009 ) ( 2010 ).", "output": [ "method" ] }, { "id": "task1163-54684f02b2a444458cf3963fe638fc33", "input": "evaluating whether viral replication is necessary for this activation.", "output": [ "purpose" ] }, { "id": "task1163-7d58096de65b463bb02cce1afd1b773d", "input": "Previously , fusion of established T cell lines or clones has been claimed to be difficult.", "output": [ "background" ] }, { "id": "task1163-bf8b5dec84cc404fb80c2dd033b603e2", "input": "This is a prospective observational study of a cohort of inpatients exposed to a severe acute respiratory syndrome ( SARS ) outbreak.", "output": [ "purpose" ] }, { "id": "task1163-55f7acb41cd949559e31878d62be13ab", "input": "Background : Chronic Hepatitis B ( CHB ) remains a major problem for global public health.", "output": [ "background" ] }, { "id": "task1163-309c3fceda014a6e878be62ff1cccd42", "input": "which occurred in June 2009 in China.", "output": [ "purpose" ] }, { "id": "task1163-3ecf56c1b0354838a90c2315b2da4219", "input": "A polymerase chain reaction-based assay for 9 respiratory viruses was performed on nasal samples.", "output": [ "method" ] }, { "id": "task1163-4c28248ceace4d54b50b5be5fbfde790", "input": "In the present work , we focused on the binding of E protein to nsp3 in infected cells and cell-free systems.", "output": [ "finding" ] }, { "id": "task1163-fec28bd9dc7741b491ca88d4dccc013a", "input": "secondary , and others from an outbreak source region when control measures are considered.", "output": [ "purpose" ] }, { "id": "task1163-3ce49a89a12e45e297227a13bffc3466", "input": "suggesting a role for a-casein in the establishment of casein micelles.", "output": [ "method" ] }, { "id": "task1163-76cdba0510174c0abc92438cd729ed18", "input": "hypothesising that it reduces the duration of the symptomatic period.", "output": [ "purpose" ] }, { "id": "task1163-f8ccae5b4968471993a4d30d1ec1c6d4", "input": "In the present study , we developed oral and nasal DNA vaccines that carried the S1 gene and N gene of IBV delivered by attenuated Salmonella enterica serovar Typhimurium strains SL/pV-S 1 and SL/pV-N , respectively.", "output": [ "purpose" ] }, { "id": "task1163-a20c458a88634cafa0d6714ba628d2fe", "input": "a 19 kDa Mycobacterium tuberculosis lipoprotein.", "output": [ "purpose" ] }, { "id": "task1163-6e6d6f3196e2482ca3805940d23e676a", "input": "In contrast , the transmembrane Cys24 appears to have no similar function.", "output": [ "finding" ] }, { "id": "task1163-637acbce1eed467e97b2611471f5a784", "input": "Genetic variation was defined through continuous distributions with varying shape and degree of dispersion for different disease traits.", "output": [ "method" ] }, { "id": "task1163-0ca7ad98d9f341248d5580313161d836", "input": "One-year mortality rates of ARDS between 1997 and 2011 in Taiwan.", "output": [ "finding" ] }, { "id": "task1163-295ef66176f54c54a378afcb594c69b7", "input": "Sera were collected at predefined time intervals and tested by ELISA for the presence of specific anti-cercarial IgY and IgM.", "output": [ "method" ] }, { "id": "task1163-05e458eb449c4a9ba7b603fc81b996e9", "input": "We offer a research perspective on the next steps for the generation of vaccines.", "output": [ "purpose" ] }, { "id": "task1163-a1dfa216214847d891b2a493cbf5b06b", "input": "and the most prominent signs were from the respiratory system.", "output": [ "finding" ] }, { "id": "task1163-aa05d1cfb4f64f128daec40465e74081", "input": "bromelain and pronase ; ( 3 ) a 55 kDa nucleocapsid protein that was phosphorylated ; ( 4 ) a 26 kDa matrix protein that was glycosylated.", "output": [ "finding" ] }, { "id": "task1163-b5a7038c47f845bea23b64cdaf482434", "input": "We review here in brief several different formulations of these representations and examples of applications to diverse problems based on what this author had presented at the Second Mathematical Chemistry Workshop of the Americas in Bogota , Colombia in 2010.", "output": [ "purpose" ] }, { "id": "task1163-a36f1c3ca03847858a657f7db5bbe900", "input": "This phenomenon called ` synonymous codon usage bias ( SCUB ) ' reflects non-uniform usage of synonymous codons encoding the same amino acid during the translation of genes to proteins ( 2,3 ).", "output": [ "background" ] }, { "id": "task1163-b21c1da2e47c498ba2eb01ce1c8641ce", "input": "Conclusions.", "output": [ "finding" ] }, { "id": "task1163-c72ae4869295421c84360f3fe41bb734", "input": "Here , we report the 3.7 Å resolution cryo-electron microscopy reconstruction of an enteroaggregative Escherichia coli baseplate subcomplex assembled from TssK , TssF and TssG.", "output": [ "purpose" ] }, { "id": "task1163-fdf510a5b68c4f34b897e025979c5684", "input": "471 ( 78.5 % ) completed all surveys while 43 ( 7.2 % ) completed none ; 150 ( 25.0 % ) reported clinical URTI.", "output": [ "finding" ] }, { "id": "task1163-28a9ae76864e4cd6a53a3036f7b0206b", "input": "as well as to case-control designs in genetically diverse populations.", "output": [ "purpose" ] }, { "id": "task1163-22fa87d2ab8f4ddf9c49633dcb7a9e9e", "input": "but seem to adopt distinct membrane topology.", "output": [ "background" ] }, { "id": "task1163-6b54122772f9453e899121cbde9796ec", "input": "where the groups receiving higher doses shed more oocysts.", "output": [ "finding" ] }, { "id": "task1163-73f7c20cd190440b8dd12cfda68c4fed", "input": "Methods : Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatment resistant chronic cough patients ( 10 selected for lavage lymphocytosis ).", "output": [ "method" ] }, { "id": "task1163-0b3f1bc4ffb04e8196de4bc7c5e72452", "input": "The comprehensive information of small molecules and their biological activities in the PubChem database allows chemoinformatic researchers to access and make use of large-scale biological activity data to improve the precision of drug profiling.", "output": [ "background" ] }, { "id": "task1163-9430b71283574db58148e216dca5f23f", "input": "We review some mathematical models developed for the study of viral zoonoses in wildlife and identify areas where further modeling efforts are needed.", "output": [ "purpose" ] }, { "id": "task1163-c384ceb470104bf0aa63ebcee7c40808", "input": "Radiographs were reviewed.", "output": [ "method" ] }, { "id": "task1163-0ff31e0eb4c44e4fa1d4a3402480ad24", "input": "Purpose : To summarize the clinical and radiologic characteristics of NCIP cases and analyze the association of radiologic findings with mortality cases.", "output": [ "purpose" ] }, { "id": "task1163-764bbb0e55a3427ba14e5a5b6e2424c3", "input": "of which 189 were from Riyadh and 283 were from Jeddah , Saudi Arabia.", "output": [ "method" ] }, { "id": "task1163-d0b8c691b89a4465a4d9a473409fe894", "input": "original research , evaluating contact isolation precautions against MDRO transmission among inpatients.", "output": [ "method" ] }, { "id": "task1163-db93c729d9a2471781f0e243b9f5a1ee", "input": "αCoVs were all detected in various genera of insectivorous bats and clustered with diverse bat αCoV sequences previously published.", "output": [ "finding" ] }, { "id": "task1163-3c0ff8eb77354a348bcb21dc49141c94", "input": "Here , we describe the heterologous expression of pAPN without signal peptide in BL21 ( DE3 ) pLysS host cells.", "output": [ "purpose" ] }, { "id": "task1163-b2116c7708224787a33f08642ad6ae4c", "input": "( a ) Sera were collected 18 days later and tested for nAb against HRV-16 and HRV-76.", "output": [ "method" ] }, { "id": "task1163-b2c739070ebf4d538eed03802dc23040", "input": "Here we show that the ezrin membrane-actin linker interacts with S endodomain through the F1 lobe of its FERM domain and that both the eight carboxy-terminal amino-acids and a membrane-proximal cysteine cluster of S endodomain are important for this interaction in vitro.", "output": [ "method" ] }, { "id": "task1163-bf317c5e6576451eb2be3b2ce2b12ea5", "input": "Suppressing the level and transcriptional activity of cccDNA might have anti-HBV effect.", "output": [ "background" ] }, { "id": "task1163-71075e91209d426cb4eeab0657fa703f", "input": "their stoichiometry and specificity of interaction is not known.", "output": [ "background" ] }, { "id": "task1163-f11ba74f465443a98d33dd80aebd9355", "input": "Further analysis suggests that domains involved in E/N interaction are largely located in both carboxyl-terminal regions.", "output": [ "finding" ] }, { "id": "task1163-7babbc7a827946408542b7e3b7f2491a", "input": "This study is a modeling-in-real-time of the emerging outbreak for understanding the state of the disease.", "output": [ "purpose" ] }, { "id": "task1163-c20e409fb5244de0b36e39493c5e4a06", "input": "Acidified milk replacer was prepared to a target pH between 4.0 and 4.5 using formic acid.", "output": [ "method" ] }, { "id": "task1163-52ab20328e8243e1a27083ae5accc505", "input": "especially among rural children , is very limited.", "output": [ "background" ] }, { "id": "task1163-14fe175fbaaa4cf18f6bc958a422b0d6", "input": "as well as the impact of vaccination on both the short-term dynamics and the long-term reduction of rotavirus incidence under varying levels of coverage.", "output": [ "method" ] }, { "id": "task1163-2a75773c1902447fa1fd6078166d2b50", "input": "Furthermore , we explored various spatial patterns and spatio-temporal evolution of Beijing 2003 SARS epidemic using spatial statistics such as Moran 's I and LISA.", "output": [ "method" ] }, { "id": "task1163-70f073452f014b0fa516c549a7182072", "input": "However , the relative importance of these antiviral immune responses and how they are related remain unclear.", "output": [ "background" ] }, { "id": "task1163-96d48163030b4f0dad1ff402b40dd466", "input": "A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum.", "output": [ "background" ] }, { "id": "task1163-51493c7c0631446aaccabdb752511fec", "input": "infected and removed persons versus time.", "output": [ "purpose" ] }, { "id": "task1163-078d3e930c4640ae8287a6b841a644eb", "input": "Different models were fitted for non-pandemic and pandemic periods and model goodness-of-fit was assessed using common model selection procedures.", "output": [ "method" ] }, { "id": "task1163-02166420366544c38bc879bbdadf094a", "input": "Hence , the visiting time of all possible visitors to a given location is the same.", "output": [ "method" ] }, { "id": "task1163-a62a39ad151a4332bab42d273e99e411", "input": "The relative risk of death or culling did not differ between treatment groups , however.", "output": [ "finding" ] }, { "id": "task1163-23337ce288774ff3a7958bed4894bfd4", "input": "Three recent inhibitor-bound PLpro structures highlight the role of an extremely flexible six-residue loop in inhibitor binding.", "output": [ "background" ] }, { "id": "task1163-f6052f30f6f343b484f1bf56ee188886", "input": "Results : The Maximum-Likelihood ( ML ) value of R0 was 2.28 for COVID-19 outbreak at the early stage on the ship.", "output": [ "finding" ] }, { "id": "task1163-6e3fe2793bda4b77ba62c380ae740284", "input": "It is possible that apoptotic bodies formed as a consequence of σ1s expression lead to reovirus uptake by dendritic cells for subsequent delivery to the mesenteric lymph node and the blood.", "output": [ "finding" ] }, { "id": "task1163-a058c794d7d649ce8a1e9584c75db1fd", "input": "and an in-house multiplex real-time PCR assay.", "output": [ "method" ] }, { "id": "task1163-fee4583db89b46b896d76a4b97d35101", "input": "• Intravenous immunoglobulin and steroids are very effective treatments for severe ITP.", "output": [ "finding" ] }, { "id": "task1163-66a611b6cf984bbba07f0eb004f5cd85", "input": "To gain insights into evolutionary forces shaping the CEA gene family we have analysed this gene family in 27 mammalian species including monotreme and marsupial lineages.", "output": [ "purpose" ] }, { "id": "task1163-3461a0ffc7344f1882f6a158456dc5e4", "input": "Their therapeutic effi cacy , however , seems limited.", "output": [ "background" ] }, { "id": "task1163-6a5f966848de4b708a2d3becca698da0", "input": "The mammalian reoviruses and rotaviruses have evolved specifi c mechanisms to evade the Type I interferon ( IFN ) antiviral response.", "output": [ "finding" ] }, { "id": "task1163-0888f5583aaf4dd2a412a86e2b80b597", "input": "and limited ( 0 < R 0 1 ) human-to-human transmissibility.", "output": [ "finding" ] }, { "id": "task1163-10592a88977a47a996152a87b0c7505d", "input": "Among these , coronavirus infection may cause life-threatening severe acute respiratory syndrome ( SARS ).", "output": [ "background" ] }, { "id": "task1163-dd423707503d486dab870240dc0e8a5f", "input": "the control of transmission via infectious air has become more important.", "output": [ "background" ] }, { "id": "task1163-f681843b6d064e9bb3ffbac62093b883", "input": "whose HimarFT insertions clustered to four genetic loci involved in lipopolysaccharidic and capsular O-antigen biosynthesis.", "output": [ "finding" ] }, { "id": "task1163-a3615e4bf5084bfe8755ecdc1d333adb", "input": "based on their initial clinical presentation.", "output": [ "method" ] }, { "id": "task1163-03eeb1f969494c4ca54ea749478c8aee", "input": "Presence of myofibroblasts and lymphoid aggregation was significantly enhanced in the grafts of PTX3 KO recipients.", "output": [ "finding" ] }, { "id": "task1163-bd1fb7e0f818409f814c32909c2d0c35", "input": "Thirtyseven children admitted with acute exacerbation of PIBO were enrolled and studied retrospectively.", "output": [ "method" ] }, { "id": "task1163-d28dac679f5441808c54dcbc267d1f35", "input": "were applied to identify the spatial risks and spatial transmission trends.", "output": [ "method" ] }, { "id": "task1163-881678619bdd4359b9b744062fd4cce0", "input": "serine proteases that co-localize with HNPs in azurophil granules , are proHNP1 activating convertases.", "output": [ "purpose" ] }, { "id": "task1163-62e3a6fe2bb349e0b880806914de298a", "input": "In this report , we describe the clinical and radiographic changes of rhesus monkeys following infection with 5 Â 10 6 PFU MERS-CoV Jordan-n3 / 2012.", "output": [ "finding" ] }, { "id": "task1163-fba93d0f455846f4b1f0e6c47469c278", "input": "Objective : This study aimed to describe the experiences of stigmatization and explore the possible factors that might be associated with stigmatization among PLHIV in Hong Kong.", "output": [ "purpose" ] }, { "id": "task1163-4afd467b14714d6ab776ef147cb4dfc5", "input": "and International Pharmaceutical Abstracts databases.", "output": [ "method" ] }, { "id": "task1163-198bf505b9854f8a9ca0065833481a00", "input": "grew in the lung , and provided homologous and heterologous protection.", "output": [ "background" ] }, { "id": "task1163-9289c90a192b4df1a55e224414f9c8d5", "input": "We investigated ECoV in rectal swabs collected from thoroughbred foals in Japan.", "output": [ "background" ] }, { "id": "task1163-1c2c2b70a97e4998b8f17eeda489c89c", "input": "defined as the number of mutations separating whole genome sequences sampled from transmission pairs.", "output": [ "purpose" ] }, { "id": "task1163-8cfefb64b4cc4049bb2e4eada88a36d5", "input": "Rockborn ( CDV-RO ) , on astrocytes in dissociated canine brain cell cultures.", "output": [ "purpose" ] }, { "id": "task1163-c6749ce48e704445857eb0c20b6bfcbe", "input": "The etiology , diagnosis and management of chyloabdomen are discussed.", "output": [ "purpose" ] }, { "id": "task1163-68e743a1f70a4842b67a8b63566cfd8b", "input": "The unpredictable and variable course of CDV-related disease may hamper correct diagnosis of infection and makes it crucial the collection of samples suitable for laboratory confirmation.", "output": [ "background" ] }, { "id": "task1163-e986a36f45d94ac593a6c1de85821155", "input": "Very limited information is currently available on the details of the active site and substrate/product binding during the catalytic cycle of these enzymes.", "output": [ "background" ] }, { "id": "task1163-bdaaf5b01512449cabfd9a9c0f8fc442", "input": "The lead FY1 antibody was further modified to revert the non-germline framework amino acid changes and affinity optimize the CDRs.", "output": [ "method" ] }, { "id": "task1163-1b1b9973ffe742b9be580291281f7d93", "input": "The identification of these factors is critical in the efforts to predict and lessen viral disease burden.", "output": [ "background" ] }, { "id": "task1163-a6bbeeccc71847c3b2ba5d6dee209008", "input": "The archaeal exosome is a phosphorolytic 3 -5 exoribonuclease complex.", "output": [ "background" ] }, { "id": "task1163-e8852b02632e443db6ada5aeefef212a", "input": "we added new factors to test whether causal mechanisms and pathogenic landscapes could be more specifically identified.", "output": [ "purpose" ] }, { "id": "task1163-c201929a70e343d7b03cfeb624c82de7", "input": "In addition , we demonstrate that a predicted 3 = RNA stem-loop structure at a noncanonical spacing downstream of the shift site is required for efficient frameshifting in TMEV and that frameshifting also requires virus infection.", "output": [ "finding" ] }, { "id": "task1163-f5e32ab2336c4202829cd3cf94cce438", "input": "what vaccines are available , and how PEDV can be treated.", "output": [ "purpose" ] }, { "id": "task1163-416a0edc2dbb48a9a8efcec15f34fe84", "input": "viral RNAs and serum IgM-IgG antibodies to SARS-CoV-2 were measured respectively.", "output": [ "method" ] }, { "id": "task1163-ca3d6188a779405b85ec69e11a9a1fbd", "input": "However , its ability to inhibit Japanese encephalitis virus ( JEV ) replication has not yet been studied.", "output": [ "background" ] }, { "id": "task1163-4883ec1e91344c33a1f562ea77bd0f50", "input": "per-capita contact rates in schools were assumed to be double that in workplaces 6.", "output": [ "method" ] }, { "id": "task1163-6e7e1cea05fa467abac793c2f8fcfccd", "input": "we studied the SARS-associated virus by electron microscopy and molecular biological technique.", "output": [ "purpose" ] }, { "id": "task1163-934cdc35c4c749fba226754b61016b59", "input": "which facilitate multiplexing , and ( ii ) artificially expanded genetic information systems ( AEGISs ) , which enable low-noise PCR.", "output": [ "method" ] }, { "id": "task1163-017dd12402a94eef81c77db59c1e1a05", "input": "employed an elegant modeling approach to capture the distributions of the number of secondary cases that arise in the community and health care settings in the context of changing population behaviors and increasing hospital capacity.", "output": [ "background" ] }, { "id": "task1163-982caf6ec16542068ae05ea1f75e0c5a", "input": "The possibility of enhancing the chemical bond between Gln and Ser based on the `` distorted key '' theory ( Anal.", "output": [ "background" ] }, { "id": "task1163-417c2cb3c06d403ca0fbf12bfac5cad7", "input": "Taken together , these results demonstrate that all nine known APMV serotypes are capable of replicating in hamsters with minimal disease and pathology.", "output": [ "finding" ] }, { "id": "task1163-2ed5f22c39bc4ee3aff02c1dbeb47513", "input": "this article attempts to provide a timely and comprehensive review of the swiftly developing research subject.", "output": [ "purpose" ] }, { "id": "task1163-6fb1b422b1824184a2c23863a49133a0", "input": "and inferred the probability and characteristics of large outbreaks.", "output": [ "method" ] }, { "id": "task1163-01ef504a62494e3d8b648a88706f66a3", "input": "from its ` discovery ' in the late 1920s to the management regime of the early twenty-first century.", "output": [ "purpose" ] }, { "id": "task1163-431e1d79d92f4114b147b0c6d9d5bf38", "input": "are used as receptors for adhesins expressed by the pathogenic Neisseriae.", "output": [ "background" ] }, { "id": "task1163-bc0b4eae6f03462aa51d0bd9fe7f27cd", "input": "mRNA and cytokine/chemokine secretion profiling were investigated for human monocyte-derived macrophages infected in-vitro with Influenza virus A/H1N1 and/or Streptococcus pneumoniae.", "output": [ "purpose" ] }, { "id": "task1163-cb5a836c78f44aa08350c8063cd7703c", "input": "and we highlight its relationship with the effort required to control an epidemic when interventions are targeted at randomly selected households.", "output": [ "finding" ] }, { "id": "task1163-1e758db5e057445f9aa3c06159bf9654", "input": "Simulations are helpful for examining the potential consequences of control options under different scenarios.", "output": [ "method" ] }, { "id": "task1163-07aae10e87f54fe291a7f9bb99897b39", "input": "Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system.", "output": [ "method" ] }, { "id": "task1163-eda93ab1a1fc4d0a9da7390de064849c", "input": "and peak neutrophil response at 24 h post-injection.", "output": [ "finding" ] }, { "id": "task1163-6118bf221a6f4dc788824d07b8c56e44", "input": "remnant DNA and environment should be considered in data analysis and results interpretation.", "output": [ "finding" ] }, { "id": "task1163-d3dd89cede694c4faff1ec6b30a503b0", "input": "Unexpectedly , the morphology and proliferation rate of iPSC were changed after nCoVN expressing for two weeks.", "output": [ "background" ] }, { "id": "task1163-b54d60982e264ba8bc4f9add636bb77a", "input": "Scheme 1 Reversible reactions used in protein-templated DCC to identify bioactive compounds.", "output": [ "finding" ] }, { "id": "task1163-5e90bede0d4f45e9928d41b43b8475c6", "input": "and to examine associations between PWD and other dam-related characteristics ( age , litter size , body mass index , and weight and number of active mammary glands of the dam ).", "output": [ "purpose" ] }, { "id": "task1163-704519c53e284a9bb61ed75be97b92fe", "input": "columnar , ciliated , and hyperplastic.", "output": [ "finding" ] }, { "id": "task1163-d93ed6209e004409be7624f736a3c699", "input": "Isolation and functional studies on feline bone marrow derived macrophages.", "output": [ "background" ] }, { "id": "task1163-f2502b7457c64fc19c545ed10d933f27", "input": "including in China , were infected and approximately 770 people died.", "output": [ "background" ] }, { "id": "task1163-fe825e28d8c44bb1929aad87d35713e9", "input": "Study design : Whole-genome and S gene sequences were obtained from nasal swabs using next-generation sequencing and phylogenetic trees were constructed.", "output": [ "method" ] }, { "id": "task1163-cca72031bb084c2096e62eb853a1eb61", "input": "but also cause severe lung injury and higher mortality rate.", "output": [ "finding" ] }, { "id": "task1163-e7e40f10f7c143fa8dc5b239dfa93028", "input": "All discussions were conducted in the local dialect of respondents.", "output": [ "method" ] }, { "id": "task1163-fe1913d3c9c44bc88f7f11f5c7e18fd1", "input": "Primary outcome measures : Fall-related injury number and rates were calculated and reported.", "output": [ "method" ] }, { "id": "task1163-56cd05feb3f344edaea28237376f7129", "input": "and its catalytic center was shown to consist of H 2820 and C 2922 residues.", "output": [ "background" ] }, { "id": "task1163-28a69cc76a4e46608d8ae62f12fe5d4e", "input": "as measured by qPCR for the HSV-1 genome.", "output": [ "finding" ] }, { "id": "task1163-2cdcc5473d1e41b192aeab7412b2fb0d", "input": "Naturally emerging and deliberately released pathogens demand new detection strategies to allow early recognition and containment.", "output": [ "background" ] }, { "id": "task1163-8727e73ca5bc49489824261131958cfd", "input": "and myasthenia gravis , as well as the advantages and disadvantages of each model and how they correlate or differ from their human counterpart.", "output": [ "purpose" ] }, { "id": "task1163-98eda2703c064419b5e70f95e6510642", "input": "but the variable factors within these two routes are not well described.", "output": [ "background" ] }, { "id": "task1163-731098d9d7e841979979ee6dbc2ab2d4", "input": "i.e. , airports , in the returning travelers in most of the countries with limited resources.", "output": [ "background" ] }, { "id": "task1163-3209b48617b44b2a9de87bbd0571fec5", "input": "A good agreement between PanCoV-RT-PCR and BCoV-RT-PCR to detect BCoV was identified ( j = 0.68 , 95 % CI : 0.392 to 0.967 ; P < 0.001 ).", "output": [ "finding" ] }, { "id": "task1163-abc7a270c8644de2b076e882e61e391d", "input": "The results of western blotting and bidirectional immune agar diffusion testing revealed that the IgY had cross-binding properties in EV71 and CVA16 strains through targeting the envelope proteins ( VP0 , VP1 and VP3 ) of EV71 and CVA16.", "output": [ "finding" ] }, { "id": "task1163-f4820780335c45b6a3e8dba716bae37b", "input": "We modified and optimized a method for generating tracheal epithelial cultures from Syrian golden hamsters and characterized the cultures for cell composition and function.", "output": [ "method" ] }, { "id": "task1163-5ab6f3ce754d424aa94d493358254232", "input": "that mice fail to mount protective MyD88-independent IFN-I responses.", "output": [ "background" ] }, { "id": "task1163-0a776e712a1145f193e51a3b8a531012", "input": "( 2 ) whether concentrations of oxygen sufficient to potentially cause oxidant injury result in morphologic epithelial alterations similar to those that occur in ozone toxicity : and ( 3 ) if the combined oxidant insult of oxygen and ozone results in more severe damage to the tracheal epithelium than occurs with ozone in air.", "output": [ "method" ] }, { "id": "task1163-8552a02e63f14a99935eab3f81835334", "input": "Together , these findings suggest that the broad antiviral effects of Orthoquin-mediated PDI may stem from damage to viral attachment proteins.", "output": [ "finding" ] }, { "id": "task1163-ff96dbd88d174eaa8ced01af6fd0590b", "input": "biological , and physical therapies.", "output": [ "method" ] }, { "id": "task1163-21dc6e86332140e58e77ecb2f75f839e", "input": "We have been using the human Ad12 Syrian hamster cell system for the analysis of epigenetic alterations in Ad12infected cells and in Ad12-induced hamster tumors.", "output": [ "background" ] }, { "id": "task1163-4d369b4022e64aeaa6d0c7a7084b2f43", "input": "N3 , by computer-aided drug design and subsequently determined the crystal 39 structure of COVID-19 virus M pro in complex with this compound.", "output": [ "method" ] }, { "id": "task1163-71b664ace1414b6080ce4fb8aa26d3e0", "input": "A 1520 bp region of Cochlosoma anatis mtDNA 16S gene was subjected to DNA sequencing and a 466 bp portion was compared with other protozoan 16S sequences to develop PCR primers specific for C. anatis.", "output": [ "background" ] }, { "id": "task1163-5a66c93b603545b6b808c81fe4ead2b3", "input": "Here , we report a 67-year-old woman with rapidly progressive pulmonary M. abscessus infection who developed OP and acute respiratory failure ( ARF ).", "output": [ "purpose" ] }, { "id": "task1163-bdcd69d1483d45179e746329d023d8e1", "input": "We conducted a retrospective study of children with histologically confirmed ELP at Red Cross Children 's Hospital , South Africa.", "output": [ "purpose" ] }, { "id": "task1163-17280f125dc24d02bd040f427979eda7", "input": "type I interferon ( IFN ) and the ubiquitin proteasome pathway.", "output": [ "method" ] }, { "id": "task1163-17648ab6fd47484980b769cd35549e68", "input": "CoVs are a group of large enveloped RNA viruses under the Coronaviridae family.", "output": [ "background" ] }, { "id": "task1163-a48f2e55d42640b1aea02043fafaedf0", "input": "We outline what methods are currently available for use in hamsters and what is readily used as well as what limitations still exist and future perspectives of reagent and assay development for hamsters.", "output": [ "method" ] }, { "id": "task1163-13e385f699fa4161b0e202417c7493f0", "input": "2.9 ( 1.0-5.0 ) , and 11.9 ( 8.3-15.7 ) per 100,000 person-years , respectively.", "output": [ "finding" ] }, { "id": "task1163-d17f64f1c54c45a9ad94bd6357369423", "input": "Background : Governments are preparing for a potential influenza pandemic.", "output": [ "background" ] }, { "id": "task1163-2006550857b64edc8dd35afe668a8df8", "input": "with consistently significant and robust effect on mortality rates.", "output": [ "background" ] }, { "id": "task1163-9fe604279ec14dd3abe257ef78363a89", "input": "it is important to recognize such findings in order to include infection with the H1N1 virus in the differential diagnosis of respiratory symptoms.", "output": [ "finding" ] }, { "id": "task1163-b2f083952e594a2d87d1481acbd631c2", "input": "Ischemia , infection , and enteral feedings are suspected to be involved in the pathophysiology.", "output": [ "background" ] }, { "id": "task1163-a011e8dd1e574ba7890f4ab1243cb652", "input": "ACD calves had access to milk replacer for 12 h/d and RES calves were offered only one feeding of milk replacer ( 3 L ) daily.", "output": [ "method" ] }, { "id": "task1163-90fa1af83e4846a3a13aab91407de95f", "input": "The intermediate hosts of most of the human coronaviruses are known , but not for HCoV-NL63.", "output": [ "background" ] }, { "id": "task1163-4d62956d828649a7a51ef18f1ed03129", "input": "with a G + C content of 37.27 %.", "output": [ "method" ] }, { "id": "task1163-20cdbf822c444a0dbaf13aa9f6a56744", "input": "transcriptional coactivators that facilitate this process are incompletely understood.", "output": [ "background" ] }, { "id": "task1163-25272c2efe324e6999cf590c822e184b", "input": "partial thromboplastin time and factors V and VIII.", "output": [ "method" ] }, { "id": "task1163-aefc85b28d1748e0a5d14a60e670e208", "input": "the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed.", "output": [ "method" ] }, { "id": "task1163-f3f2eb9b70d44a8982365c96c9b1c7a2", "input": "Methods : We conducted a cross-sectional study of pediatric patients with respiratory symptoms in a Singaporean pediatrics hospital.", "output": [ "method" ] }, { "id": "task1163-26e9041f1034467189dc6c28b5d64872", "input": "and is rapidly evoked when the pathogen-associated molecular patterns ( PAMPs ) of viruses are sensed.", "output": [ "background" ] }, { "id": "task1163-b63f849352da499389e328fc9cbc9fc6", "input": "Emerging evidence indicates that pro-inflammatory cytokines modulate brain excitability.", "output": [ "background" ] }, { "id": "task1163-354d53c85c9042f7bf967bfcff2e584f", "input": "epidemiological and outbreak investigations , and in complementing preventive approaches for the control and management of foodborne pathogens.", "output": [ "background" ] }, { "id": "task1163-5d0e176a74724e0f9518921b3b743d25", "input": "up to March 8 , 2018.", "output": [ "method" ] }, { "id": "task1163-5ed5240f17894f0d8683e222918419c9", "input": "Individual cysteine clusters were altered via cysteine-to-alanine amino acid replacement and the modified S glycoproteins were tested for their transport to cell-surfaces and ability to cause cell fusion in transient transfection assays.", "output": [ "method" ] }, { "id": "task1163-8ef97509e50943f0b1783ca20e275399", "input": "Cases were not more likely to be hospitalized than controls.", "output": [ "finding" ] }, { "id": "task1163-e5aa054a5e904006809ad87ba74d3374", "input": "Trial registration : Clinical Trials Registration : NCT01158560.", "output": [ "finding" ] }, { "id": "task1163-34c57814ebd84865b1419480772d7025", "input": "Mycobacterium bovis , which lost its virulence in humans by being specially subcultured in an artifi cial medium.", "output": [ "finding" ] }, { "id": "task1163-c514094cf72340adb1cb2b06383c0c15", "input": "we here present a Y2H protocol that is well suited for high-throughput screening.", "output": [ "method" ] }, { "id": "task1163-1a00ff0406f54f66b8eb738675119214", "input": "This study aimed to assess the uptake of recommended vaccines and to identify the factors associated with the vaccines ' uptake among Malaysian Hajj and Umrah pilgrims.", "output": [ "purpose" ] }, { "id": "task1163-75d9a06640944e53bc5ed650ca3c7f04", "input": "Attention is given to human behavior regarding the family dog and responsible dog ownership.", "output": [ "background" ] }, { "id": "task1163-0305418eb17a414ba3ecf4a962d7bf1b", "input": "and observational study included 55 patients with COVID-19 who were transferred to Shenyang Sixth People 's Hospital between January 20 and March 15 , 2020.", "output": [ "method" ] }, { "id": "task1163-bece55c67ff74c50a7b1755e1c3069a3", "input": "we adopt a few simplifications.", "output": [ "method" ] }, { "id": "task1163-e9524f5d56db4ffc81acbab479e49fa8", "input": "Results : Twelve non-cases drank unpasteurized camel milk and had contact with camels.", "output": [ "finding" ] }, { "id": "task1163-9778d7451efa49b59f5a48c5d2e5fc7c", "input": "computational , and combinatorial strategies and assess the potential of these approaches for the development of new vaccines and immunotherapeutics.", "output": [ "purpose" ] }, { "id": "task1163-48c4ecda3b5b465db535abf284b16e06", "input": "affecting over 100 countries in a matter of weeks.", "output": [ "background" ] }, { "id": "task1163-781a2d2a769e45d5a766a63e0efd370a", "input": "The present study was undertaken to determine immune response and protection efficacy of a spike ( S ) protein fragment containing neutralizing epitopes ( 4F/4R ) of turkey coronavirus ( TCoV ) by priming with DNA vaccine and boosting with the recombinant protein from the corresponding DNA vaccine gene segment.", "output": [ "purpose" ] }, { "id": "task1163-1d5104ea32cd42c6b62788eaf8559978", "input": "The underlying mechanisms and potential protective role of exogenous PTX3 as a therapy should be further explored.", "output": [ "finding" ] }, { "id": "task1163-8fa48de6ef434e4d88c4c1c42d5922f7", "input": "Interstitial inflammation , parenchymal fibrosis and bronchiolitis obliterans scores were significantly higher in KO mice.", "output": [ "finding" ] }, { "id": "task1163-23e0fcc572c341aabadf21ef00b58452", "input": "Purpose : This study was designed to identify factors associated with death by 6 months post-intensive care unit ( ICU ) discharge and to develop a practical mortality risk score for extracorporeal membrane oxygenation ( ECMO ) treated acute respiratory distress syndrome ( ARDS ) patients.", "output": [ "purpose" ] }, { "id": "task1163-a3fd334959284b6a8498611bebe3294c", "input": "Arabian strains of the virus should be tested for changes in virulence and transmissibility.", "output": [ "finding" ] }, { "id": "task1163-99ac21833666491fbd627799645d04c1", "input": "which we have validated in functional studies.", "output": [ "finding" ] }, { "id": "task1163-3589cca2864a4753b6d7c3fb3b36e90b", "input": "and use of blood culture in CAP is still increasing.", "output": [ "purpose" ] }, { "id": "task1163-976c9cc0d7e440828663f910d194a55e", "input": "In this research article , an attempt has been made to understand the qualitative behavior of a virus infection model with Lytic and Non-Lytic Immune Responses by perturbing with randomness ( white noise ) via Lyapunov technique.", "output": [ "purpose" ] }, { "id": "task1163-b1c50d3e0ce34e398e1c5ea3bbef4792", "input": "This document discusses routes of transmission of infection and the principles of current infection control measures.", "output": [ "purpose" ] }, { "id": "task1163-48e47c5537984bd1b096e21feb96fa7f", "input": "to name only a few examples.", "output": [ "background" ] }, { "id": "task1163-75dfa2a252de46b7b39d609aae4e8068", "input": "Now is the time for us to reframe our role in the health system that is evolving to a process of care focused on population health and patient safety that pays providers for value they bring to achieve those goals.", "output": [ "purpose" ] }, { "id": "task1163-0528229c03754a9382683221cfa7f766", "input": "Objectives : We set out to assess the quality of MERS-CoV molecular diagnostics worldwide.", "output": [ "purpose" ] }, { "id": "task1163-62711ab90a174f4f9c5c92951feef747", "input": "as well as existing , vaccines , making them more effective.", "output": [ "finding" ] }, { "id": "task1163-e82b4f56d4c84e41bd6492cd77c58796", "input": "including a summary of basic knowledge of their biology.", "output": [ "purpose" ] }, { "id": "task1163-08f51f3163ed4f9e8f52bdabfe8ba204", "input": "In addition , a brief review of two pathways intimately associated with cell division is provided because of their potential for pharmacologic manipulation.", "output": [ "purpose" ] }, { "id": "task1163-e882690f755a4a149deba1bd10fba5ce", "input": "and ( 3 ) builds data-based simulation models to identify factors that most strongly affect patterns of prevalence.", "output": [ "purpose" ] }, { "id": "task1163-ececd7aedfc441d6a2ee262d5ede3e30", "input": "with distinct `` club-like '' projections formed by the spike ( S ) protein ( 23 , 24 ).", "output": [ "background" ] }, { "id": "task1163-639c3645a9f94c3e9f64eaf4b8dc7101", "input": "Methods : Patients admitted to two sentinel hospitals between 2010 and 2014 who met the SARI case definition were enrolled.", "output": [ "method" ] }, { "id": "task1163-374057d3a79f495d98cc93a4bab4c2db", "input": "as were the WBC count and the C-reactive protein and procalcitonin levels.", "output": [ "finding" ] }, { "id": "task1163-0e477052f00d4c7b858d69dbac20f654", "input": "G6PD genotyping for Mahidol , Kaiping and Mediterranean mutations was performed for 128 out of 196 samples by real-time multiplex PCR.", "output": [ "method" ] }, { "id": "task1163-811ec89cf52c431f936823619143a90d", "input": "the benefits of vaccination and antiviral use might be significantly compromised if these control programs are not designed appropriately.", "output": [ "finding" ] }, { "id": "task1163-062b0a4441b64cf2bd1b57eba6f4b494", "input": "and until death 44 was 15.93 ( 95 % CI : 13.07 , 18.79 ).", "output": [ "finding" ] }, { "id": "task1163-5ceeb39c468646ee976187382258b1f9", "input": "Recipient PTX3 deficiency enhanced chronic rejection-like lesions by promoting a fibrotic process in the airways and lung parenchyma.", "output": [ "finding" ] }, { "id": "task1163-13a3bb06a1974c4a9848ac5d6e0ba6c8", "input": "This paper presents an empirical spatio-temporal analysis of epidemiological data concerning 2321 SARS-infected patients in Beijing in 2003.", "output": [ "purpose" ] }, { "id": "task1163-e8fc9a9e8e094d92b301c1d5c7fea197", "input": "Abstract Bovine viral diarrhea virus ( BVDV ) is an important pathogen of cattle that plays a complex role in disease.", "output": [ "background" ] }, { "id": "task1163-7753db747a9a4e2f871f0097362496e0", "input": "indicating that the membrane is essential in stabilizing the peptide conformation that will be able to inhibit viral infection.", "output": [ "finding" ] }, { "id": "task1163-e04290bdcb8941ad9e955c966f22af32", "input": "nurses , pharmacist and technicians individually.", "output": [ "purpose" ] }, { "id": "task1163-075861f76a7b42329f55d40d2c74db79", "input": "suggesting that they were stably expressed in the shell gland tissue.", "output": [ "finding" ] }, { "id": "task1163-620c25539ec748fcb5045b669f9a098d", "input": "a kinase required in interferon signaling.", "output": [ "background" ] }, { "id": "task1163-8061f773d91a4c728287ed65eb9abf6a", "input": "inhibit growth of vaccinia virus ( VACV ) in vitro.", "output": [ "purpose" ] }, { "id": "task1163-dd49e7a865f644c09dddffad77c57a41", "input": "covered in a separate article.", "output": [ "purpose" ] }, { "id": "task1163-6b40923cf6cd4c7299f17e7ca6f98d5c", "input": "but also suggest novel strategies that target protein-protein interactions as much needed antivirals.", "output": [ "purpose" ] }, { "id": "task1163-788b74640e7048b4acee248d32ac3eeb", "input": "including outbreaks of highly transmissible diseases through high quality care within the context of universal health coverage.", "output": [ "background" ] }, { "id": "task1163-acd936f0574145399b7144d9f2c5d59d", "input": "• We investigate the similarity among US and Chinese stock indices for the Asian currency crisis and the global financial crisis.", "output": [ "purpose" ] }, { "id": "task1163-937fcc5185df4657ad13d4e64a5e2b61", "input": "Herein , we report a facile approach to increase antigen size to achieve not only fast but also effective responses against the recombinant HA/H7N9 protein via a simple conjugation of the protein onto the surface of nanodiamond particles.", "output": [ "purpose" ] }, { "id": "task1163-17f0f4c91bde43c4ad9c79e4a01d1aa3", "input": "The majority of APMV-infected hamsters exhibited transient histological lesions that self resolved by 14 days post infection ( dpi ).", "output": [ "finding" ] }, { "id": "task1163-167bb75b55b341848c2ea21b15f40ea4", "input": "Regarding viral circulation , BCoV was detected in 10 % ( 3/30 ) of all calves and BCoV IgG1 Ab seroconversion was detected in 42 % of the total animals showing that almost half of the calves were infected with BCoV.", "output": [ "finding" ] }, { "id": "task1163-6864e55e6b96402eb430c2c782ad0c99", "input": "in the entry of HAdV-D37 into primary human corneal fibroblasts.", "output": [ "purpose" ] }, { "id": "task1163-a99240f0e87f461ab0e724ce7f24fb27", "input": "Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time.", "output": [ "background" ] }, { "id": "task1163-b3250152acad496989abc46fea213985", "input": "their various modes of action and gives an update on the applications of intrabodies in human diseases.", "output": [ "purpose" ] }, { "id": "task1163-2ddb317d9ee74bac9224df0e61c7a14c", "input": "Survival of SARS-CoV strain GVU6109 was studied in stool and respiratory specimens.", "output": [ "method" ] }, { "id": "task1163-82d21c10927c4520bc3d3274a7d41caa", "input": "Therefore , vaccination targeting older children might protect infants from RSV infection.", "output": [ "finding" ] }, { "id": "task1163-61f6fa5b1a19459da2d01a05e71c685e", "input": "in this study we demonstrate that direct delivery in mice of an infectious ZiKV cDnA clone allows the rescue of recombinant ( r ) ZiKV in vivo.", "output": [ "purpose" ] }, { "id": "task1163-3e98abac4e064a4aaaa4a4ecb475f03d", "input": "Additionally , some pigs were euthanatized after a second LPS administration for bronchoalveolar cell analysis and virological examinations of the lungs.", "output": [ "method" ] }, { "id": "task1163-bd139dd035af405486653f92ce8f2676", "input": "Time of emergence of clinical signs and survival rate were not significantly different between the two groups.", "output": [ "finding" ] }, { "id": "task1163-b3c82a31c3cf4a7d8459bff117259672", "input": "there are several other recognizable uses and potential impact of these systems on the public and global public health.", "output": [ "background" ] }, { "id": "task1163-3bd718cf07c64d05ac89e60f4b0e9c03", "input": "The purpose of this case study was to determine how the program affected the shelter cat intakes over time.", "output": [ "purpose" ] }, { "id": "task1163-4ba39db743514edaa76729792062381f", "input": "The double proline mutant V55P / S71P displayed no fusion activity despite being well expressed at the cell surface as a proteolytically cleaved trimer that could bind red blood cells and change conformation at low pH. The impairment in fusion for both V55P and V55P/S71P was at the level of outer leaflet lipid mixing.", "output": [ "finding" ] }, { "id": "task1163-a624a04e8c4d489f90cd8c2c8e86cb03", "input": "Gross pathology and histopathological findings were background changes and were not considered enrichment-related.", "output": [ "finding" ] }, { "id": "task1163-ce96b9cd443b4298b3799937aa9a5378", "input": "Intriguingly , a minor proportion of the SARS-CoV E protein was found to be modified by N-linked glycosylation on Asn 66 and inserted into the membranes once with the C-terminus exposed to the luminal side.", "output": [ "finding" ] }, { "id": "task1163-df5a1ba58a324af6a24a3189b0cb320a", "input": "In addition , we provide an up-to-date list of bat species in China.", "output": [ "purpose" ] }, { "id": "task1163-ac279c8f7aee407a9dbcfff14eeace7e", "input": "A value of p < 0.05 was considered statistically significant.", "output": [ "method" ] }, { "id": "task1163-17dd60971dfe4a31a819253ec91f7a5c", "input": "with 93-100 % agreement for all comparisons.", "output": [ "finding" ] }, { "id": "task1163-8dd6534470634c1888675fad52f06df4", "input": "nutraceutical and ethnomedical uses as well as the biological and pharmacological effects and toxicity of this plant based on 218 literary sources reported over 40 years.", "output": [ "purpose" ] }, { "id": "task1163-ae9d23b491e743259ec80ff3aa38274a", "input": "Interviews and specimens were collected from 565 consenting HCWs.", "output": [ "method" ] }, { "id": "task1163-eda2d662b089434e967ab158c2de1941", "input": "We aimed to describe the frequency and predictors of virus and bacteria codetection in children with ARI and cough , irrespective of clinical diagnosis.", "output": [ "purpose" ] }, { "id": "task1163-140b928bd1ab4c38816ada7e658f46ec", "input": "We describe the case of a healthy man who presented with severe ITP complicated by intracranial haemorrhage following upper respiratory tract infection.", "output": [ "background" ] }, { "id": "task1163-52d4c21c92dd436d89c64f8f260ed4ba", "input": "MEDI8852 , effectively reacting with all influenza A hemagglutinin ( HA ) subtypes.", "output": [ "purpose" ] }, { "id": "task1163-4d100d146d5b4595908eb03d199eb22f", "input": "and this study aims to evaluate the long-term results of a spleen-invigorating Huo-Gu Formula ( HGF ) therapy in these patients.", "output": [ "purpose" ] }, { "id": "task1163-fcdeba7cd8974b099b65693d6cfcaa06", "input": "Quantitative data were to analyze completeness and timeliness of surveillance system performance from national District Health Information System 2 ( DHIS2 ).", "output": [ "method" ] }, { "id": "task1163-42d9b203d8204501a66403a20bb7bdbf", "input": "5 ( 55.6 % ) of the 9 deaths occurred within the third or fourth week.", "output": [ "finding" ] }, { "id": "task1163-3cb2bb4537d74ea2b267474fbb4fcbb3", "input": "Aim : To estimate R 0 in nosocomial outbreaks of MERS.", "output": [ "purpose" ] }, { "id": "task1163-d1acc7914f424c459d7f2b77d65d1bbe", "input": "and the estimated cumulative cases would reach 1514 ( 1384-1656 ) at the tenth day in the future.", "output": [ "finding" ] }, { "id": "task1163-2d7cfda2a04e46bb95e4daf9d62df0d2", "input": "Stably transformed Lemna were obtained by co-cultivation with A. tumefaciens EHA105 harboring the PEDV spike protein gene.", "output": [ "method" ] }, { "id": "task1163-d8009562040f453a984fcd0bc554afcd", "input": "and recent developments in technologies and policy for detecting and controlling epidemics that have been initiated intentionally.", "output": [ "purpose" ] }, { "id": "task1163-03b1630bc04a4264a948caacaaf8a1f6", "input": "with coefficients of variation ( CV ) less than 3.43 and 3.33 % , respectively.", "output": [ "background" ] }, { "id": "task1163-1726d669948b4d10912e51fc6415c9e6", "input": "Rotavirus likely represses the IFN response by at least 4 mechanisms.", "output": [ "finding" ] }, { "id": "task1163-90d52e0645f049c1bf287e5744f50c60", "input": "Structurally different from T20 , AP3 could fold into single-helix and interact with gp41 NHR.", "output": [ "finding" ] }, { "id": "task1163-830205f972744929ac7ca65771cef53c", "input": "and the lay public in understanding the progress of Ebola virus disease and the continuing outbreak.", "output": [ "background" ] }, { "id": "task1163-29c9b4d825b344b2b3cc6bc9927ee902", "input": "are effective in the prevention of centrogenic PE.", "output": [ "finding" ] }, { "id": "task1163-0110c74a51944b67affc871bcbc25ad5", "input": "A cross-sectional design was used to analyze data collected between August 2017 and December 2017 from eight hospitals in southern Taiwan.", "output": [ "method" ] }, { "id": "task1163-de5f0f6e7d12483daa27361ef1fc076d", "input": "In this study , we determined whether the complex and reactive CNS environment of the mouse hepatitis virus ( MHV ) model of multiple sclerosis ( MS ) could support transplant-mediated remyelination.", "output": [ "purpose" ] }, { "id": "task1163-fa20896edefa48bfb210329bbc16db60", "input": "2014 to October 31 , 2014.", "output": [ "method" ] }, { "id": "task1163-150b451447ad40729260638408c4ca64", "input": "including from social and economic standpoints.", "output": [ "background" ] }, { "id": "task1163-cc1cbb3911f44341b3987f1e17250f79", "input": "including the variety of life cycles they have developed and the mechanisms by which they have adapted to evolving changes in habitat and host availability.", "output": [ "purpose" ] }, { "id": "task1163-fd23b4705ead4dbd917fd3cd03b22495", "input": "in an effort to highlight some of the unanswered questions regarding the coordination of the IAV infection process.", "output": [ "purpose" ] }, { "id": "task1163-c7a83b90b2184141a9cc351c4743d54a", "input": "including administrative , patient , and legal issues.", "output": [ "purpose" ] }, { "id": "task1163-07bc94c5d1694f9ca4797861ec69d25e", "input": "Introduction of a CMV promoter upstream of the nsP genes allows direct transfection of plasmid DNA with self-replicating RNA capacity ( 19 ).", "output": [ "method" ] }, { "id": "task1163-04acf00df30244a397cc08780961873e", "input": "Here , we will discuss the role of TDP-43 and FUS in SG dynamics and how disease-linked mutations affect this process.", "output": [ "purpose" ] }, { "id": "task1163-eedd202debb74abdb330af4d737c4e6f", "input": "resulting in a non-productive system in the case of virus outbreaks because early detection and management of the same can become increasingly dependent upon the technological backbone of smart cities.", "output": [ "finding" ] }, { "id": "task1163-e87753f07ba04b648e340c64aa1be99d", "input": "The seventh novel human infecting Betacoronavirus that causes pneumonia ( 2019 novel coronavirus , 2019-nCoV ) originated in Wuhan , China.", "output": [ "background" ] }, { "id": "task1163-ebc73cc19ea44b72886f2fb90648206f", "input": "derived from 1 - ( x - ( 4-bromophenoxy ) alkyl ) uracil derivatives - previously reported inhibitors of human cytomegalovirus ( HCMV ).", "output": [ "purpose" ] }, { "id": "task1163-83937e94f29b4f4cad4f7f88bb0cd9ab", "input": "which is suggestive of a common therapeutic target for both types of enterovirus.", "output": [ "finding" ] }, { "id": "task1163-c450045efc50434eb056b80f66f102db", "input": "This article reviews what is currently known about the virus and the disease.", "output": [ "purpose" ] }, { "id": "task1163-8d811c8bbf654adaada48aa34b2be30d", "input": "Here , we systematically reviewed studies that performed viral mNGS in common livestock ( cattle , small ruminants , poultry , and pigs ).", "output": [ "purpose" ] }, { "id": "task1163-cffc32010aa4455e83ce420639b4dd37", "input": "and show that kinetic constants determined from FRET-based assays that are uncorrected for inner-filter effects can lead to artifacts.", "output": [ "finding" ] }, { "id": "task1163-3d3127d6dda54d168f55fcec67f354a5", "input": "Arizona conducted surveillance for severe acute respiratory infections ( SARI ) among adults hospitalized in the Arizona-Mexico border region.", "output": [ "background" ] }, { "id": "task1163-8eb54bae7960481eace60266b5d90b64", "input": "Outbreaks of gastroenteritis may lead to serious disruption when many persons are absent from work or school.", "output": [ "background" ] }, { "id": "task1163-1016cfd121e2462583d89fb27bb21100", "input": "Nesting material and shelters were used frequently and consistently and allowed animals to display species typical behavior.", "output": [ "finding" ] }, { "id": "task1163-0b9c333264f44a068c53ba4b13345ff0", "input": "although it is much needed for patient contracting the severe form of the disease.", "output": [ "background" ] }, { "id": "task1163-a2fd8a3dd52b4f2bb786d47f8129d485", "input": "A lncRNA discovery pipeline was implemented that identified 15,558 liver-expressed lncRNA genes.", "output": [ "finding" ] }, { "id": "task1163-22aabb22fc1141068c0e8a13c359f6e1", "input": "Objective : The purpose of our study was to review the initial high-resolution CT ( HRCT ) findings in pneumonia patients with presumed/laboratory-confirmed novel swine-origin influenza A ( H1N1 ) virus ( S-OIV ) infection and detect pneumonia earlier.", "output": [ "purpose" ] }, { "id": "task1163-f90c32a0f4eb4ba685fd3d5d1eda3b29", "input": "Using this approach , we demonstrate that mycophenolic acid ( MPA ) can inhibit the GTase reaction by preventing the catalytic transfer of the GMP moiety onto an acceptor RNA.", "output": [ "finding" ] }, { "id": "task1163-a23e3604bdae4892b6539be460a57992", "input": "were cultured in the absence or presence of cadmium ( Cd ) acetate or mercuric ( Hg ) chloride.", "output": [ "method" ] }, { "id": "task1163-a548ca333ad442fbaca0047f29b68d24", "input": "Employees who attended on-site arrangements had higher influenza vaccination rate ( 97.0 % ).", "output": [ "finding" ] }, { "id": "task1163-da64e4cf92fa4259a75b6838d54accd1", "input": "PDCoV identification was conducted by using a PCR protocol previously described ( 6 ).", "output": [ "method" ] }, { "id": "task1163-d642396826b24ce9ba2dbbb44d6d6aa2", "input": "Analysis of the autoprocessing kinetics in vitro reveals that proteolysis at the Q 2779 - S 2780 site is the first cleavage event mediated by this proteinase.", "output": [ "finding" ] }, { "id": "task1163-aeadb1023b3f4394b8937c5133f9a2ec", "input": "Background-Respiratory infections are the most common infectious diseases in humans worldwide and are a leading cause of death in children less than 5 years of age.", "output": [ "background" ] }, { "id": "task1163-8ba324264e084456906bde2beadf2fbc", "input": "Methods : 33 patients participated in semi-structured interviews.", "output": [ "method" ] }, { "id": "task1163-452614a43c66418a8acd2ac6efcecf45", "input": "the first step in the preparation of β-amino acids.", "output": [ "purpose" ] }, { "id": "task1163-844bb3f281054d64bdf3a2d9a5bd7e7f", "input": "Expression of both the MisL-and 987P subunit FasA-fusions to the TGEV epitopes were under the control of in vivo-induced promoters.", "output": [ "method" ] }, { "id": "task1163-980f734f1fa2420e984ca9975436d3e1", "input": "leading to a mortality rate of 3.4 %.", "output": [ "background" ] }, { "id": "task1163-7dbe47a3c0ed416c8a47907e196997bc", "input": "with a particular focus on systems that achieve good transfection and minimize potential toxicity.", "output": [ "method" ] }, { "id": "task1163-43ab89d647a441d3bb8351d990711790", "input": "It is this group with established asthma in whom acute exacerbations triggered by virus infections remain a serious cause of increased morbidity.", "output": [ "background" ] }, { "id": "task1163-0fdae4def5814a25b1b39fb85807f650", "input": "and 11 % the risk becoming ill when infected.", "output": [ "finding" ] }, { "id": "task1163-fae6de1012734f53a9848079eb530188", "input": "Objective : The RDV method was further modified to reduce the candidate PCR primer sets.", "output": [ "purpose" ] }, { "id": "task1163-0d1b7154e098470396f3864f8c2619c5", "input": "and S. sonnei were assessed to find the most antigenic protein.", "output": [ "method" ] }, { "id": "task1163-4e73e718a11346a68e273521ef43678b", "input": "Direct expression of AXB or BXA produces protein catenanes with distinct ring sizes.", "output": [ "background" ] }, { "id": "task1163-2fe61f0369f44371a2db32ad501912bc", "input": "Here , we reviewed discovery and development of BSAAs and summarized the information on 119 safe-in-man agents in freely accessible database ( https://drugvirus.info/ ).", "output": [ "method" ] }, { "id": "task1163-5b014d0eecf44f378e6965d22d34abf2", "input": "In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development.", "output": [ "purpose" ] }, { "id": "task1163-6cf5d78bf08e4047b8728103a21f736b", "input": "( III ) During the COVID-19 epidemic ophthalmologists may have to deal with patients affected by conjunctivitis of other nature and have no guidelines on how to make a differential diagnosis.", "output": [ "background" ] }, { "id": "task1163-cf959c4b61974ea9aebed482e5ca8fc3", "input": "ABCA1 regulates cellular cholesterol homeostasis.", "output": [ "background" ] }, { "id": "task1163-8222cd6e274741078b11af0225b5a714", "input": "Therefore , a prospective case-control study was conducted to determine the prevalence of respiratory viruses in CRS patients and non-CRS controls.", "output": [ "purpose" ] }, { "id": "task1163-2e18a30ebf0d402cacf3ad9b6688ffe4", "input": "We conducted a narrative and tabulated synthesis of the results.", "output": [ "method" ] }, { "id": "task1163-87782fd7fb0d42e6ac7a7c92694cd401", "input": "the neuropathogenicity of SAFV remains undetermined.", "output": [ "background" ] }, { "id": "task1163-3e8715679a754598b530c6c795945c42", "input": "In first experiment , 100 adult house flies were divided into control and treatment groups equally.", "output": [ "method" ] }, { "id": "task1163-9856ec7de80b47098f7a8507f8d19ef2", "input": "thus providing favorable conditions for virus production.", "output": [ "finding" ] }, { "id": "task1163-e78ff6738de34cd1bcf5c23fa9776948", "input": "angiogenesis and other body functions.", "output": [ "background" ] }, { "id": "task1163-a792cd7451eb47989f0edb6b0bd942f5", "input": "The aim of this study was to screen a population of 54 cats from Sardinia ( Italy ) for the presence of both FPV and CPV DNA within buffy coat samples using polymerase chain reaction ( PCR ).", "output": [ "purpose" ] }, { "id": "task1163-f41b3dae6c1e4cd99f120a503c2bf9d7", "input": "compared with the scenario of no travel restriction.", "output": [ "finding" ] }, { "id": "task1163-5a99c14fd3b24642853bcdf04682a299", "input": "Here , we elaborated an initial assessment of the impact of TLR9 triggering on EBV-positive and EBV-negative B-cell lymphoma using Burkitt 's lymphoma ( BL ) cell lines as an in vitro model.", "output": [ "method" ] }, { "id": "task1163-3abc9c4571a340d1bc9c97fc2acfa2a0", "input": "This paper presents a case-study of news communication regarding the emergence of pH1N1.", "output": [ "purpose" ] }, { "id": "task1163-4f72f39bd83a48829ab814571c829650", "input": "and ( 3 ) review of the current status of rabies and tetanus human vaccine in vitro potency methods for their potential application to the corresponding veterinary vaccines.", "output": [ "finding" ] }, { "id": "task1163-4014b5e7f28e4afaa817906a6149c9d7", "input": "the phylogenetic relationships of PEDV strains in the regions of epidemicity in the Philippines to PEDV strains that are endemic in other countries were investigated.", "output": [ "method" ] }, { "id": "task1163-31c2129dc61d4c309b889538bb8f352e", "input": "This commentary suggests that the growing technology of DNA synthesis should be fully implemented as a means to rapidly generate in vivo data and possibly actionable therapeutics soon after sequence data becomes available.", "output": [ "finding" ] }, { "id": "task1163-80a6d4612515495193d762ed0df60730", "input": "which may even lead to death.", "output": [ "background" ] }, { "id": "task1163-5bac1581ba6a4028813230ccffdbf183", "input": "cells ) were constructed.", "output": [ "method" ] }, { "id": "task1163-580ccd85b8ba4a00a9f6caac228a34d2", "input": "their molecular substrates , and their contributions to disease.", "output": [ "purpose" ] }, { "id": "task1163-2b00c0d6133d4f3b9b72a33dd37cf668", "input": "household contacts , and healthcare personnel.", "output": [ "method" ] }, { "id": "task1163-307601036f3c4bb1b98caf8eae415cb9", "input": "p38 MAPK , c-Fos and c-Jun.", "output": [ "finding" ] }, { "id": "task1163-5cd414cb595741aa8db27b9cbd6116d7", "input": "Based on these data , additional clinical trials are in development to evaluate influenza vaccine candidate antigens manufactured using Spodoptera frugiperda ( Sf9 ) / baculovirus-based VLP technology.", "output": [ "finding" ] }, { "id": "task1163-02b812f2aa3449a9ba8640fe1181a9e7", "input": "For the positive group , samples were selected for the detected viral species.", "output": [ "method" ] }, { "id": "task1163-25713acf48454d868c0b9a7e887a167b", "input": "we need a novel therapeutic approach other than EGFR inhibitors.", "output": [ "purpose" ] }, { "id": "task1163-ff920d92d8fc4d3f8442628cb3fe95dc", "input": "by scrubbing the sites using sterile flocked swabs.", "output": [ "method" ] }, { "id": "task1163-8a84800462e74ca588b1e3c1f72ebc89", "input": "The current treatment options are limited.", "output": [ "background" ] }, { "id": "task1163-3ac89c6988e8455ebcfa6b2059d4a7fb", "input": "Both amplification and spatially resolved signal generation take place on immobilized forward primers bount to expoxysilanized glass surfaces in a pump-driven hybridization chamber.", "output": [ "method" ] }, { "id": "task1163-8bba0df6a590408f921199b43e90ae94", "input": "swelling , tenderness , and redness reported in the higher VLP dose groups ( 15 g and 45 g ) compared to the placebo and 5 g VLP groups following both vaccinations.", "output": [ "finding" ] }, { "id": "task1163-c6bc7c9fa5df4d56b82233ed87a903bd", "input": "Rodent health monitoring programs make an essential contribution to biomedical research by identifying the presence of infectious agents that might confound animal research.", "output": [ "background" ] }, { "id": "task1163-3234a3dec97b4b39a20edf47e6c2cc6a", "input": "a b s t r a c t 2-Deoxy-a-D-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance.", "output": [ "background" ] }, { "id": "task1163-7b6c83e130a94786bcd84050f9e6fee9", "input": "or monitored until 14 dpi ( n 2 ).", "output": [ "method" ] }, { "id": "task1163-3d81210f207841e4b23fb7642cc7c73d", "input": "as well as the various etiologies and pathophysiologic mechanisms giving rise to this important disease entity.", "output": [ "method" ] }, { "id": "task1163-11951355362d4d34a08ca8bc0707e934", "input": "Comparing the panda pMHC-I to others 21 in the bear family and extending the comparison to other mammals revealed distinct features.", "output": [ "purpose" ] }, { "id": "task1163-732c838ec8bd40beb52546fd6a085ea6", "input": "The aim of the current study was to analyse the effect of both antigen and adjuvant on the cellular and humoral vaccine-induced immune responses by comparing the native ASP to a recombinant version expressed in Pichia pastoris ( pASP ) and replacing QuilA by Al ( OH ) 3.", "output": [ "purpose" ] }, { "id": "task1163-7ac92f0b224a448d8869fa95ee289a3a", "input": "The purpose of this study was to analyze the SCUB patterns of the four sequenced cotton species and explore the key factors influencing codon choice.", "output": [ "purpose" ] }, { "id": "task1163-93ceb1b9a90b47e48587c9796391cf62", "input": "it has been known that blood cultures have low yields and rarely affect clinical outcomes.", "output": [ "purpose" ] }, { "id": "task1163-a3369c8dee114d798e1414915f3b346c", "input": "but not with increased mental illness.", "output": [ "background" ] }, { "id": "task1163-251afbedf3c54613a756b147feae1c3d", "input": "antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply.", "output": [ "purpose" ] }, { "id": "task1163-42b9dd32942f46668a80c117fe857679", "input": "we evaluated pathogenicity by using a new premature reproductive tract pathogenicity model.", "output": [ "method" ] }, { "id": "task1163-527ca6e4336949339883b12ecd4886ba", "input": "The severity of a patient 's illness was assessed by chart review post-discharge looking for clinical markers of respiratory status such as presenting symptoms , diagnoses , and interventions.", "output": [ "method" ] }, { "id": "task1163-8c61bbb813b542cc813c88adcd2e2d61", "input": "RV-specific sequences were identified by partial sequencing of VP4/VP2 and 5 ′ non-coding regions with 80 % success rate.", "output": [ "method" ] }, { "id": "task1163-e4c4138a7ed74f0bb86314551c67bc52", "input": "more than 70 % and 90 % of contacts respectively had to be traced to control the majority of outbreaks.", "output": [ "finding" ] }, { "id": "task1163-835ba97479ac4fe1ad0538b965cb62ef", "input": "recent studies indicate it may represent a combination of immune responses.", "output": [ "background" ] }, { "id": "task1163-065dcf15cc9842b09eaef2f864070bdd", "input": "mechanically interlocking SpyX modules named AXB and BXA.", "output": [ "background" ] }, { "id": "task1163-1d713f832a114cf98336f1caef202974", "input": "retrotranscription polymerase , Monoplex polymerase chain reaction ( PCR ) and Multiplex PCR.", "output": [ "method" ] }, { "id": "task1163-4a973f055ae44b78a4a69152fb606b23", "input": "the area under the ROC curve was 0.86 ( 95 % CI 0.75-0.97 ) and setting sensitivity at 86 % gave specificity of 71 %.", "output": [ "finding" ] }, { "id": "task1163-a0747301386144cfa75854fa96c11a5f", "input": "Cyclophosphamide was used to immunosuppress hamsters leading to a prolonged disease course and higher mortality after SARS-CoV infection.", "output": [ "method" ] }, { "id": "task1163-e4a7cc7b94994f4298ef01037f732cd3", "input": "The aim of this study is to investigate the expression of cytokines in AECOPD.", "output": [ "purpose" ] }, { "id": "task1163-bb7a0cf6cf804cd7bcee5cc799735c3c", "input": "The effects of face mask wearing were investigated using multilevel ( hierarchical ) modelling.", "output": [ "method" ] }, { "id": "task1163-83a78fc11c1142c3b6810adbdeb0e4af", "input": "This review focuses on technological advances which allow this interaction to be studied in much greater detail.", "output": [ "purpose" ] }, { "id": "task1163-96f580a444f84879813eeb22c11a5460", "input": "We developed a testing algorithm for high throughput screening of livestock sera with ELISA and confirmation with recombinant immunofluorescence assay testing for antibodies against HCoV-NL63 in livestock.", "output": [ "method" ] }, { "id": "task1163-ace77fab80004a59b98410ce6166db3d", "input": "including many cancers , autoimmune , metabolic and infectious diseases.", "output": [ "background" ] }, { "id": "task1163-8e9f51d6963848a2b05dcb4bc4c2510b", "input": "conjunctivitis , diarrhoea and outbreaks have been reported.", "output": [ "background" ] }, { "id": "task1163-9daded99a60841e78acf690df6ce1c6f", "input": "others might highly depend on the particular ward structure under study.", "output": [ "purpose" ] }, { "id": "task1163-f3bee9ac062c48fe816481aa09a076e7", "input": "in the Serengeti National Park , Tanzania.", "output": [ "purpose" ] }, { "id": "task1163-e2f54613a8614105a77f44c4bdab58ab", "input": "Albuquerque UP ( 2019 ) Adaptive memory and evolution of the human naturalistic mind : Insights from the use of medicinal plants.", "output": [ "finding" ] }, { "id": "task1163-05c8034704f9490db0cd04f294b69501", "input": "come in different sizes , shapes and symmetries.", "output": [ "background" ] }, { "id": "task1163-ab02b454419d4adabd1833ec6ade2bcb", "input": "sequenced , and compared with other TGEV strains genes selected from the GenBank.", "output": [ "method" ] }, { "id": "task1163-6d19f3dfcca34c06b05f77d7517ceac2", "input": "including an indirect ELISA ( iELISA ) ; a highly specific monoclonal antibody-based blocking ELISA ( bELISA ) ; fluorescent microsphere immunoassays ( FMIA ) that can be multiplexed to monitor exposure to multiple antigens and pathogens simultaneously ; and a fluorescent focus neutralization assay ( FFN ) to measure functional virus neutralizing antibodies.", "output": [ "purpose" ] }, { "id": "task1163-61108382f5734ad086080fe888541fcb", "input": "MERS-CoV continues to be an endemic , low-level public health threat.", "output": [ "background" ] }, { "id": "task1163-4d9e62704cb6437791aa920b9f59d129", "input": "the only vesicle that was fused by DV fusion peptide.", "output": [ "method" ] }, { "id": "task1163-926d0dc406a84916bda83c6e9f477a50", "input": "The analytical sensitivity of the EEDV-LAMP method was estimated to be as low as 16 copies of plasmid per reaction.", "output": [ "finding" ] }, { "id": "task1163-6e57c4236ad04a6f8efe1ad55002fe1e", "input": "In this study , three effective siRNAs targeting NS3 of CSFV were selected.", "output": [ "method" ] }, { "id": "task1163-14e4add5853842abbbe4d3479291e07b", "input": "Mutants were expressed in COS or 293T cells and assayed for cell surface expression and structural features as well as for their ability to change conformation and induce fusion at low pH. We found the following : Specific mutations affected the precise carbohydrate structure and folding of the HA trimer.", "output": [ "method" ] }, { "id": "task1163-c1a339bafa9945dea08392565de9d04b", "input": "Meanwhile , iPSC-nCoVN lost the ability for differentiation into cardiomyocytes when using a routine differentiation protocol.", "output": [ "finding" ] }, { "id": "task1163-ead863a38eaf4b4498820785a639fccb", "input": "Echinococcus multilocularis and Baylisascaris spp. ).", "output": [ "finding" ] }, { "id": "task1163-6aaae596f94a45b99ee65d8d35561721", "input": "sensitive , multiplex discrimination of microbial gene sequences and report its application for detecting 22 respiratory pathogens in clinical samples.", "output": [ "purpose" ] }, { "id": "task1163-bad6ba68d05a4a278badcff0b6fadccd", "input": "and the mCAT-1 transfectants did not show the relative resistance of NIH 3T3 cells to Spl574.", "output": [ "finding" ] }, { "id": "task1163-f82c3c428637486e9f81da6fe6a75590", "input": "as well as hand hygiene compliance rates.", "output": [ "method" ] }, { "id": "task1163-37ee57e1bd2440c195ffaae97da2af0d", "input": "including intravenous ( IV ) ceftriaxone , azithromycin , and linezolid.", "output": [ "background" ] }, { "id": "task1163-cd0efa207f754c61b937ca4ee4e522e1", "input": "We give examples of the Cavbase similarity analysis detecting pronounced similarities in the binding sites of proteins unrelated in sequence.", "output": [ "method" ] }, { "id": "task1163-66dfaa5124394cdf9ebf7cef9ef55437", "input": "The gram-negative coccobacillus now designated as Yersinia pestis has been discovered as the causative agent of plague in this Hong Kong outbreak.", "output": [ "background" ] }, { "id": "task1163-8386d00c87f74dc4b947b48d02e18c81", "input": "We cite recent examples of virus emergence that exemplify how arboviruses have exploited the consequences of the modern human lifestyle.", "output": [ "method" ] }, { "id": "task1163-88ae6313075b46b0bd833200d677f601", "input": "factors that may place healthcare workers at higher risk for infection.", "output": [ "finding" ] }, { "id": "task1163-cc8aed2beaba4267a0ae31c1ab3ff34a", "input": "On Western blots , 40 cercarial and 7 schistosomular antigens were recognized by IgY from infected ducks.", "output": [ "finding" ] }, { "id": "task1163-5246169d1180405e80592a892862551c", "input": "An unpaired t-test was used for statistical analysis of the drugs ' effects.", "output": [ "method" ] }, { "id": "task1163-26d2517ea8be4e759b3103da3ab53dca", "input": "we speculate that this building principle is a blueprint for cell-surface architectures utilized by viral particles.", "output": [ "purpose" ] }, { "id": "task1163-5e64a7d65d40460cb98d50cfb55e7290", "input": "Administered drugs and intervention times were compared in 47 and eight patients with mild and severe symptoms , respectively.", "output": [ "method" ] }, { "id": "task1163-2d108dbdc4704583ac3886b4f4103617", "input": "Therefore , the present case-control study aimed to determine the levels of 90 IL-1 family ( IL-1β , IL-37 ) and IL-12 family ( IL-12 , IL-35 ) in these patients and the 91 association between these cytokines levels and the patients ' demographic 92 characteristics.", "output": [ "purpose" ] }, { "id": "task1163-214d24b3a2504d419d0ae71829a19173", "input": "bites and scratches from bats and the use of bats for food , medicinal or ritual purposes.", "output": [ "method" ] }, { "id": "task1163-f0e89fa8b48b460a89a935525632025d", "input": "The objective of this study was to explore the use and perceptions of a local Severe Acute Respiratory Syndrome ( SARS ) Extranet and its potential to support future information and communication applications.", "output": [ "purpose" ] }, { "id": "task1163-cb350033234b4db395bf1a9f12c22e61", "input": "The RNA guanylyltransferase ( GTase ) is involved in the synthesis of the m7 Gppp-RNA cap structure found at the 59 end of eukaryotic mRNAs.", "output": [ "background" ] }, { "id": "task1163-629220e89e2a4ca0903b3b69bed088b2", "input": "The viruses associated with acquired immunodeficiency syndrome and hepatitis are also discussed.", "output": [ "finding" ] }, { "id": "task1163-55c14d6ff42846ec8e18651e74e7b7d3", "input": "Correlation analysis of mean SMK of 708 case study residential units determined by the detailed computer simulation method and the corresponding angle of unobstructed sky showed that the latter can be used to assess view obstruction adequately close to simulation predictions.", "output": [ "finding" ] }, { "id": "task1163-e5b88b67b8c54fef880fc0b7cd65380c", "input": "This difference in timing between these 2 groups was significant ( P = .004 ).", "output": [ "finding" ] }, { "id": "task1163-027d8c7cd6dd4a088406dcfcaf670a74", "input": "For this study , we determined the genome sequences of BYD1 and the S1 gene sequences of other five mammalian reovirus isolates ( BLD , JP , and BYL were isolated from different SARS patients during the outbreak , 302I and 302II were isolated from fecal specimens of two children of Beijing in 1982 ) to allow molecular comparison with other previously reported mammalian reoviruses ( MRVs ).", "output": [ "purpose" ] }, { "id": "task1163-e9dc3db725f74f8683a43205317c0d04", "input": "Reads were processed using Mothur and QIIME pipelines and assigned 12,345 OTUs for C1 and 5,408 OTUs for C2.", "output": [ "method" ] }, { "id": "task1163-4af535d99d264c51bc238179893da80b", "input": "we screened a library of F. tularensis subsp. tularensis Schu S4 HimarFT transposon mutants in GFP-LC3-expressing murine macrophages by microscopy for clones localised within autophagic vacuoles after phagosomal escape.", "output": [ "method" ] }, { "id": "task1163-aaf3a7efe6c14714bb14e6462493e600", "input": "which is observed for hydrogen peroxide.", "output": [ "finding" ] }, { "id": "task1163-4cb2ca34079343e987f004f50acb10fc", "input": "National guidelines recommend that healthcare workers ( HCW ) who use N95 masks require fit testing.", "output": [ "background" ] }, { "id": "task1163-3872e6c4fccc44cfb50e227edbfafde3", "input": "Currently , RT-PCR is a reliable test in detecting both symptomatic and asymptomatic COVID-19.", "output": [ "finding" ] }, { "id": "task1163-69e78a189ad94e4795b8f21ec4e4cbbc", "input": "Persistence of CDV in the brain appears to be due to non-cytolytic selective spread of the virus with very limited budding.", "output": [ "finding" ] }, { "id": "task1163-a3e046d731a4426da705e35a43a8603d", "input": "was used to assess specificity in acute cases.", "output": [ "method" ] }, { "id": "task1163-50659efb45fe41679681ca7d8a126c68", "input": "which can be used to understand the contribution of host genetics to vaccine efficacy.", "output": [ "method" ] }, { "id": "task1163-b023ba190ff74d5f9ce1de18e268d347", "input": "Capillary electrophoresis indicated that DON at concentrations as low as 200 ng/ml evoked selective rRNA cleavage after 6 h and that 1000 ng/ml caused cleavage within 2 h. Northern blot analysis revealed that DON exposure induced six rRNA cleavage fragments from 28S rRNA and five fragments from 18S rRNA.", "output": [ "method" ] }, { "id": "task1163-93df3139ef8a411cb3d23583c6887189", "input": "Plasma membrane cholesterol was depleted from common carp brain ( CCB ) cells with methyl-b-cyclodextrin ( MbCD ).", "output": [ "method" ] }, { "id": "task1163-2cf6f79429264f468ea56fa5b28d9d8d", "input": "Examination of practical , theoretical and methodological values of findings includes considering research needed and the utility of safety measure information in business decision making.", "output": [ "finding" ] }, { "id": "task1163-2d55bd887d74485d85f8a126198bf402", "input": "After a disaster , our society requires resilience to return to normalcy following the disaster 's physical and social impact.", "output": [ "background" ] }, { "id": "task1163-af21666ecc714a7887d97c766a9068a2", "input": "We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus.", "output": [ "method" ] }, { "id": "task1163-98b66049f7b74d4ba1fcd4ce096b6eff", "input": "as illustrated with the chosen examples from the literature.", "output": [ "finding" ] }, { "id": "task1163-97d21d76771c4f9cae4abbce0aacc8cb", "input": "and technical issues in relation to commonly used approaches to surveillance.", "output": [ "purpose" ] }, { "id": "task1163-b2d860cc61ef4d33ae31b2b1a4bc47f6", "input": "We recently introduced Cavbase , a method for describing and comparing protein binding pockets on the basis of the geometrical and physicochemical properties of their active sites.", "output": [ "method" ] }, { "id": "task1163-356aa2f3c16b48e6b9508d7289d9a5a6", "input": "Thermodynamic model for the performance estimation of the combined system is investigated.", "output": [ "method" ] }, { "id": "task1163-b2b223141cdc4fbeb341a6c9270ebb7e", "input": "Each author should submit a separate form and is responsible for the accuracy and completeness of the submitted information.", "output": [ "method" ] }, { "id": "task1163-8c0ea4d14a174bbb8030bdfa6e628250", "input": "We investigated the clinical characteristics of COVID-19 patients with AMI and determined the risk factors for AMI in them.", "output": [ "purpose" ] }, { "id": "task1163-6ba8c4e52d2246d0ac3fa774744e51ff", "input": "This review provides the latest update on the interplay between human host factors/processes and non-polio enteroviruses ( NPEV ).", "output": [ "purpose" ] }, { "id": "task1163-bf73ff65cad64758a001200cfe3194db", "input": "Here , we show that the host response to a single JHMVspecific immunodominant CD4 T-cell epitope is critical for severe disease.", "output": [ "purpose" ] }, { "id": "task1163-4c5280e6ba064333af446872907676e4", "input": "We provide an overview of the current status of HEV antiviral research.", "output": [ "purpose" ] }, { "id": "task1163-eddd519766104a93bce501480cd03ff8", "input": "and operon structures , thus improving the structural annotation in bacteria.", "output": [ "background" ] }, { "id": "task1163-3cfd0200563940a8aa033726272fc722", "input": "while the oxygenation index levels were below normal and continued to decline in the fatality group.", "output": [ "finding" ] }, { "id": "task1163-06cf5f67aac84e729e0daecd9903d154", "input": "which causes 0.8 million deaths a year.", "output": [ "background" ] }, { "id": "task1163-f2a101354f314547befd4300a5950f2f", "input": "The study of HCoV-host interactions has contributed extensively to our understanding of HCoV pathogenesis.", "output": [ "background" ] }, { "id": "task1163-3459d659646c4bf5b52d3033e25cdebe", "input": "stimulation with lipopolysaccharide ( LPS ) induced the production of biologically active interleukin 1.", "output": [ "finding" ] }, { "id": "task1163-d0e801ff93d142138b495187f5472a10", "input": "and likelihood a patient could be infected based on symptoms and testing.", "output": [ "method" ] }, { "id": "task1163-f158cc2fbcae4a69a7a07247f44ea907", "input": "consistent with attenuation by slower growth as opposed to reduced mutational supply.", "output": [ "finding" ] }, { "id": "task1163-cd369107ff414693882efa712d783225", "input": "Nonetheless , the intriguing HBV genome has not been well characterized.", "output": [ "background" ] }, { "id": "task1163-4fbfba36a0a74541a6e7d00888e30d0d", "input": "laboratory samples and methods and identified pathogens.", "output": [ "method" ] }, { "id": "task1163-395da90a3084484e9d554c0a7eba73b3", "input": "suggesting that E palmitoylation modification or disulfide bond formation is not required for SARS-CoV virus assembly.", "output": [ "finding" ] }, { "id": "task1163-0339b0bb3fd549dba40aa1ffa2333685", "input": "A cluster tree was developed from the profiles retrieved from the presence and absence of homologs of ten 2019-nCoV proteins.", "output": [ "method" ] }, { "id": "task1163-ff1f2d07570243c7a0712e59306d4d67", "input": "and virus detection was performed by polymerase chain reaction.", "output": [ "method" ] }, { "id": "task1163-d759a789c7cb41e886c3e81789d99eba", "input": "anticipatory disaster stress , and motivation for disaster engagement.", "output": [ "purpose" ] }, { "id": "task1163-357f7242a2b346a7b8a20a142c821f06", "input": "The papain-like cysteine proteases encoded by the coronavirus ( SARS-CoV : PLpro ; NL63 : PLP1 and PLP2 ) represent potential targets for antiviral drug development.", "output": [ "background" ] }, { "id": "task1163-38931528a64d4bcba763434aa7180249", "input": "Interviewees were observed donning and doffing an N-95 respirator as they normally would during patient care.", "output": [ "method" ] }, { "id": "task1163-d93e56206e5541afa3567e245b8e25f0", "input": "indicating that OAS1 dysfunction is associated with impaired surfactant catabolism due to the defects in AMs.", "output": [ "finding" ] }, { "id": "task1163-eb1eff9c9e8f4e759e965ee30580a3ef", "input": "Here , we investigated whether HCoV-EMC and SARS-CoV induce similar or distinct host responses after infection of a human lung epithelial cell line.", "output": [ "purpose" ] }, { "id": "task1163-88b2ff3187c449bb8bf4abc7b7308735", "input": "Acute bacterial sinusitis is a frequent complication of viral upper respiratory infection ( URI ).", "output": [ "background" ] }, { "id": "task1163-13987c0085394bb38f1e8289acb748c8", "input": "including substrate binding mode and coordination of the nucleophilic water molecule.", "output": [ "finding" ] }, { "id": "task1163-e3ae037e0c674926aebf6f145bb4dc0e", "input": "this review highlights some of the controversies regarding the implementation and efficacy of these interventions.", "output": [ "purpose" ] }, { "id": "task1163-dadf921f5b2d4774a02920b2f10614f0", "input": "Ten patients were admitted to the designated hospital.", "output": [ "method" ] }, { "id": "task1163-847cc2b4589d403aa81a265ed8d2e3c6", "input": "We simplified the scenario by dividing each indoor environment into different sub-visiting locations that represent different time durations for visiting each indoor environment.", "output": [ "method" ] }, { "id": "task1163-cafe9859009b45bfa18c89cf24ee5ef9", "input": "On day 5 , the physician who had performed intubation presented with numerous furuncles of the fingers and face.", "output": [ "finding" ] }, { "id": "task1163-ee31627d81a84f85ba0675556a5702d2", "input": "This review describes our current understanding of potential APCs in the CNS and the contribution of these and other CNS-resident cells to disease pathology.", "output": [ "finding" ] }, { "id": "task1163-2247f361483342869ffba4ae957e5d67", "input": "The 68K '' '' protein was also detected on the surface of metabolically labeled BALB/cV tumor cells by an external immunoprecipitation technique.", "output": [ "finding" ] }, { "id": "task1163-1cc5c137a56843ca9011ba1bf544e17b", "input": "The goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen.", "output": [ "purpose" ] }, { "id": "task1163-7b56cd39a4364739af6211bd9ca026e3", "input": "Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries.", "output": [ "background" ] }, { "id": "task1163-9b87aa5ee374402dbe60b52435fa710c", "input": "particularly among natural colonies of bats.", "output": [ "background" ] }, { "id": "task1163-51dde55ae95e4991802b9c3e09e77819", "input": "Later still necrosis develops.", "output": [ "background" ] }, { "id": "task1163-c511c34dcfde4124baadf596de996596", "input": "utilising a diagnostic strategy incorporating molecular testing.", "output": [ "purpose" ] }, { "id": "task1163-b8baa70aec4b40bca2a102da1aed7de1", "input": "Viral infections play several different roles in asthma in childhood.", "output": [ "finding" ] }, { "id": "task1163-b36808a432e14a57afe74e763ed98dcc", "input": "we investigated the combination of IFN-b and ribavirin.", "output": [ "method" ] }, { "id": "task1163-a9f51fc689d8446d9df2b9b9dc33fb30", "input": "exfoliated enterocytes , and parasitic worms.", "output": [ "finding" ] }, { "id": "task1163-1df6bd5994a543a0bc4e6072b8fcd9e9", "input": "The characterization of the responses of target cells to ZEBOV infection may therefore not only further understanding of pathogenesis but also suggest possible points of therapeutic intervention.", "output": [ "purpose" ] }, { "id": "task1163-33845cb5801f4ec1a379347f5d7667da", "input": "We argue that disease-related news ( DRNs ) should not trigger rational trading.", "output": [ "method" ] }, { "id": "task1163-ceba50f8946f427e806eaf2301eabb7a", "input": "The phylogenetic relationship between the isolated magnetic strains and some known magnetotactic bacteria was inferred by the construction of phylogenetic tree based on 16SrDNA sequences.", "output": [ "method" ] }, { "id": "task1163-3a1544438f3e4178877a2e1aa384cb58", "input": "a sulfated glycan , less efficiently than wild-type CVB3 did.", "output": [ "finding" ] }, { "id": "task1163-05ae97ce433c47d39121ffb7202f1a12", "input": "Here , we investigated the antiviral activity of MBL in infection by dengue virus ( DENV ) , a related flavivirus.", "output": [ "purpose" ] }, { "id": "task1163-9344a3205bae4dcfb69e1cb4cae6574c", "input": "2H phosphoesterases catalyze reactions on nucleotide substrates and contain two conserved histidine residues in the active site.", "output": [ "background" ] }, { "id": "task1163-0120ef92404f437f8d1b6315dea47400", "input": "There were 7 pens/diet with 11 pigs/pen and 8 pens/diet with 31 pigs/pen.", "output": [ "method" ] }, { "id": "task1163-821e08cd382744ce8ca861d0b558338f", "input": "We have tried to disrupt this helical conformation by mutating L141 to T in the stable inactive monomer G11A/R298A/Q299A.", "output": [ "method" ] }, { "id": "task1163-9c883deed9954950b8f68d15b233798e", "input": "and South AfricaÕs increasingly prominent political and commercial role in Africa.", "output": [ "background" ] }, { "id": "task1163-b412479a9eb84b12bb751b5049d326ed", "input": "Additionally , NQ 4 disrupted the viral attachment of HHV-1 to Vero cells ( EC 50 : 0.12 µg/mL , 0.38 µM ) with a very high selectivity index ( SI = 1728 ).", "output": [ "finding" ] }, { "id": "task1163-ab2aa20f2fa44d3f9e2cef91488b6538", "input": "This case highlights the necessity for health care workers to protect themselves against transmission of infectious diseases from patient to care giver.", "output": [ "background" ] }, { "id": "task1163-0eee8b1978db4aff87b485fb2a21ce31", "input": "cesarean-derived , colostrum-deprived ( CDCD ) piglets.", "output": [ "method" ] }, { "id": "task1163-f7da0351f5514ab48acc44dbb0d4bf0e", "input": "Approximately half the reports on protein microarrays have been published in the last two years especially in the area of biomarker discovery.", "output": [ "background" ] }, { "id": "task1163-50ea02fd323b42fe90d2cf0b1f449320", "input": "with peak positivity at ages 5-9 years.", "output": [ "finding" ] }, { "id": "task1163-c05fabf06c0945f8a53ae77188d50da3", "input": "characterization of cell tropism , and how to perform antiviral assays and quantify viral replication.", "output": [ "purpose" ] }, { "id": "task1163-93c537c509f4491993b720df691b96c9", "input": "These increased yields provide sufficient quantities of active enzyme for use in NMR-based ligand mapping.", "output": [ "background" ] }, { "id": "task1163-9627151905a343c09ed25ead2e44ebf8", "input": "Discussions on disaster resilience have been increasing in recent years.", "output": [ "background" ] }, { "id": "task1163-d6e9caea415b422488c5540407f48284", "input": "Memorizing medicinal plants for the treatment of serious diseases likely maximized the chances of survival and reproduction and was instrumental in the evolutionary success of our species.", "output": [ "background" ] }, { "id": "task1163-b7c0fd089282495784a3387f25b58303", "input": "the implementation of such approaches in low-and middle-income countries ( LMICs ) is often restricted due to limited resources and underdeveloped infrastructure.", "output": [ "background" ] }, { "id": "task1163-9174a891ae5c4c7e8978e092461e41c8", "input": "by cataloguing genomic features for strain discrimination and by observing clinical features in positive patients.", "output": [ "purpose" ] }, { "id": "task1163-c584b9e241b048eea0de608e931a4b0d", "input": "The sensitivity and specificity of the newly developed LAMP assay compared to the SYBR Green qPCR assay were 84.3 % and 93.3 % , respectively.", "output": [ "finding" ] }, { "id": "task1163-77d9cbf9052c4371ac71553272f12e14", "input": "with relevant samples collected to assess virus infection and antiviral responses.", "output": [ "method" ] }, { "id": "task1163-bcdb5c8ba9a94faaa1098c97dec51286", "input": "whereupon analysis can take place.", "output": [ "background" ] }, { "id": "task1163-475969ee9a4b4422b08fdd625519498b", "input": "This study analysed the consequences of deviation from the WHO case definition for the assessment of patients with suspected severe acute respiratory syndrome ( SARS ) in The Netherlands during 2003.", "output": [ "purpose" ] }, { "id": "task1163-d1b1de6553c34b5ba7143441e46725b2", "input": "The isolated protein product contains the brazzein domain folded with correct disulfide bonds formed and is then cleaved with a specific SUMO protease to liberate native brazzein.", "output": [ "finding" ] }, { "id": "task1163-deb2278611b140f69e50e88ae147847c", "input": "causes acute diarrhoea and dehydration in pigs.", "output": [ "background" ] }, { "id": "task1163-d3fc92a4216f440790c16dac922f2f84", "input": "Our purpose is to demonstrate the importance of mathematical modelling for the understanding and management of infectious disease transmission.", "output": [ "purpose" ] }, { "id": "task1163-a4fdf613a99c43a9af87ebbf88725aaf", "input": "Findings PLANET relies on real-time information from three levels of participants in large-scale programs : funders , managers and recipients.", "output": [ "background" ] }, { "id": "task1163-31791941468f4a64bf82efef5f214731", "input": "this perturbation may protect DENV and related viruses from innate immunity and create a favorable replicative environment.", "output": [ "finding" ] }, { "id": "task1163-5ccfcc83988f46aea6745154ee7080e5", "input": "Additional evidence for the pivotal role of extracellular cysteines in the APN molecule was obtained when substitution of any of these six cysteines caused complete loss of surface expression and enzymatic activity.", "output": [ "finding" ] }, { "id": "task1163-2b973110f2a94e918780b23373df5131", "input": "Here , we develop mathematical models with multiple infection stages and estimate parameters based on within-host data to investigate the impact of behavior change on influenza dynamics.", "output": [ "purpose" ] }, { "id": "task1163-f082123d13664f6c8eb12039a8a991e4", "input": "paediatric , emergency/Intensive medication wards.", "output": [ "method" ] }, { "id": "task1163-d1bf860cfab442278cfd0bdc751257f3", "input": "the study of host response and immunopathogenesis is difficult.", "output": [ "background" ] }, { "id": "task1163-babdbc2314a14b7ab88cbcafdd972be2", "input": "N63Y mutant CVB3 may be useful as a platform to understand viral adaptation and pathogenesis in animal studies.", "output": [ "finding" ] }, { "id": "task1163-573c0f11416f4f17951737d14f9be4ef", "input": "and this cytopathic response was accompanied by the accumulation of unintegrated viral DNA.", "output": [ "finding" ] }, { "id": "task1163-fd6f9bf6f015413ba8c14327160b4e02", "input": "Diarrhea is one of the most common causes of antimicrobial use and mortality in young calves.", "output": [ "background" ] }, { "id": "task1163-60c0fc92268843c599849c0d39b6ffcd", "input": "operate and analyze moving objects ' relationships and introduces two algorithms ( relationship querying and relative relationship dynamic pattern matching ) to derive and analyze the dynamic relationships of moving objects.", "output": [ "purpose" ] }, { "id": "task1163-e6be1bdf4f1e4ab8be2e74e3d2fa751e", "input": "Massachusetts and QX-like strains showed different cleavage site motifs.", "output": [ "finding" ] }, { "id": "task1163-7b8079dc736141bd906e1c0ee6719423", "input": "Both proteins contain a single transmembrane-spanning segment but are integrated in the membrane with opposite orientations.", "output": [ "background" ] }, { "id": "task1163-77c1905ac93e417e9875efc5516f0428", "input": "Objectives : To determine the viruses associated with ALRI among children living in the PNG highlands using sensitive molecular detection techniques.", "output": [ "purpose" ] }, { "id": "task1163-68bc2c1ec5d34dc7853c3d16ec3fd37b", "input": "The q ~ 6 system is a useful model for the recombination of other segmented double-stranded RNA viruses such as the Reoviridae.", "output": [ "finding" ] }, { "id": "task1163-6dba1b174fb3439f95b182fba297ab68", "input": "review the main factors that shape these transmission heterogeneities and examine the interface with human health.", "output": [ "purpose" ] }, { "id": "task1163-b28ebe1279964042b1150b0ca252ee77", "input": "replication , virion assembly and eventual egress of the NPEV from the infected cells.", "output": [ "method" ] }, { "id": "task1163-1d34699d2282454e8e6efa061df7e861", "input": "Further , this protein has also been proposed to be an efficient diagnostic tool and a candidate vaccine against the SARS-CoV.", "output": [ "purpose" ] }, { "id": "task1163-3e1a8e9a11d741de853d9c8d6b75bce0", "input": "The independence of the SARS-CoV E enhancement effect on VLP production from its viral packaging capacity suggests a distinct SARS-CoV E role in virus assembly.", "output": [ "finding" ] }, { "id": "task1163-206c1371159b423cb5056168aaa5bf28", "input": "deubiquitylases ( DUBs ) was made by the development of activity-based probes ( ABPs ).", "output": [ "background" ] }, { "id": "task1163-639028167d6d491e893f0d27304f9f98", "input": "The antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus ( VSV ) in HeLa cell cultures.", "output": [ "finding" ] }, { "id": "task1163-1bc98433dc9b4db1807cfa2d60e02b38", "input": "This review outlines the approaches to isolating and studying human antiviral mAbs and discusses the common principles underlying the basis for their activity.", "output": [ "purpose" ] }, { "id": "task1163-fe269f6eb6764830b4e256f74205cbcd", "input": "Thus , the aim of this study was to evaluate fecal S100A12 concentrations in a cohort of puppies with intestinal parasites ( Cystoisospora spp. , Toxocara canis , Giardia sp. ) and viral agents that are frequently encountered and known to cause gastrointestinal signs in dogs ( coronavirus , parvovirus ) as a comparative model.", "output": [ "purpose" ] }, { "id": "task1163-37ed2e24c6f14fddb3e8f08b04650210", "input": "with the effect of travel restriction adopted by Wuhan on 2019-nCoV infection in Beijing being almost equivalent to increasing quarantine by a 100 thousand baseline value.", "output": [ "finding" ] }, { "id": "task1163-dc320241427947a0a6ccf048a4f11526", "input": "biopolitics and governmentality , this article shows how Chirac 's attempt to produce self-regulating and responsible dog owners through education failed to persuade them to overcome their disgust at their pets ' excrement.", "output": [ "purpose" ] }, { "id": "task1163-7204d087a9234ea290f1ee4e42c339dd", "input": "PBs and SGs are able to release mRNAs thus allowing their translation.", "output": [ "background" ] }, { "id": "task1163-263800cfa66a4a8ea0bda0cc9b634e6a", "input": "Here we develop a mathematical model to aid public health authorities in tracking the expansion and contraction of outbreaks with explicit representation of factors ( other than population immunity ) that may slow epidemic growth.", "output": [ "background" ] }, { "id": "task1163-bbfe647ae151482596534960f7bf45fa", "input": "We provide the first empirical evidence for the role of airline travel in long-range dissemination of influenza.", "output": [ "purpose" ] }, { "id": "task1163-c3e7f5aa2c6e4c16bf5ae692e9db9fac", "input": "HLIUs identified sustainability challenges and reported the highly infectious diseases they would treat.", "output": [ "finding" ] }, { "id": "task1163-8cbd9f6fb07c47fca9e5775168a70268", "input": "but not large neurons , with the UR strain also infecting epithelial cells.", "output": [ "finding" ] }, { "id": "task1163-dfadc0c0b6564175b800f8fc8b0914c2", "input": "Six topics were addressed in detail by speakers and workshop participants and are reported in a series of six reports.", "output": [ "background" ] }, { "id": "task1163-1906964c8a1f42018f536bf98ab7633f", "input": "This review presents some of the latest experimental designs for infectious disease challenges with BTV or SBV.", "output": [ "purpose" ] }, { "id": "task1163-db9216736a6a4381b6663ebe2221f5b0", "input": "Here we present a nuclear role for TRIM25 in specifically restricting influenza A virus replication.", "output": [ "purpose" ] }, { "id": "task1163-773376d9f8514a0e886c9b20a39340a6", "input": "In the present study , we investigated the whole genomic sequence of a SARS-like bat CoV ( 16BO133 ) and found it to be 29,075 nt in length with a 40.9 % G+C content.", "output": [ "method" ] }, { "id": "task1163-5f63e869a63d42aa8b6ecda311916acc", "input": "which developed the epidemic more recently.", "output": [ "method" ] }, { "id": "task1163-16b672b698aa48c095f6cabafd740eb5", "input": "as was seen in the 2009 H1N1 influenza pandemic.", "output": [ "background" ] }, { "id": "task1163-fc5f1d2130984789b6ba3910992f5f79", "input": "Moreover , pre-exposure to the wild-type VTT via intranasal or intraoral route impaired the Nab response via the same routes of MVTT-S vaccination probably due to the pre-existing anti-VTT Nab response.", "output": [ "finding" ] }, { "id": "task1163-5087248377144160aed7d16b9a4eefaf", "input": "SARS-CoV-2 emerged by the end of 2019 to rapidly spread in 2020.", "output": [ "background" ] }, { "id": "task1163-47254e0c25224610aa8c438fbb9883d2", "input": "The purpose of this study was to isolate BCV strains from feces derived from CD and WD in human rectal tumor ( HRT-18 ) cells and to compare the antigenic and biological properties of these strains.", "output": [ "purpose" ] }, { "id": "task1163-076e26a6ab82404fa4ac10e1e94df6c0", "input": "Background : Improving accuracy and efficiency of computational methods that predict pseudoknotted RNA secondary structures is an ongoing challenge.", "output": [ "background" ] }, { "id": "task1163-8f3bcc9092c3406e9d81179e0a952e4b", "input": "geometric mean ratios ( GMRs ) and seroconversion rates were also all statistically higher in the VLP groups compared to placebo for both post-baseline time points.", "output": [ "finding" ] }, { "id": "task1163-574a0ceabbc54d058edb8d8705fd1c6e", "input": "Mitochondria elongation promotes DENV replication and alleviates RIG-I-dependent activation of interferon responses.", "output": [ "finding" ] }, { "id": "task1163-83c83dd620cc446b8fb1025b96b1577a", "input": "which varied between different times ( 2014 and 2015 ) and places.", "output": [ "finding" ] }, { "id": "task1163-3145b1a5c4ea4706a4bf1ccd9604f329", "input": "The characteristics of human respiratory activities have also been investigated using some familiar engineering techniques.", "output": [ "background" ] }, { "id": "task1163-76dd76ab72f94279809c1659afa31f18", "input": "a known translational inhibitor , induces ribosomal RNA ( rRNA ) cleavage.", "output": [ "background" ] }, { "id": "task1163-bdd526a8e2fc43af803b5241249d8de9", "input": "In this Review , we take a multidisciplinary and holistic perspective and review the multiple aspects of school closure as a public health policy.", "output": [ "purpose" ] }, { "id": "task1163-7b8341fa97754a9a872d451ac6f9d280", "input": "beliefs , and practices of respiratory protection.", "output": [ "method" ] }, { "id": "task1163-23cf9e438f0543d49a71bc7f337957cb", "input": "In a reverse reaction it synthesizes A-rich RNA tails.", "output": [ "background" ] }, { "id": "task1163-3b4643dea4ae45f1a3dc9a90e1dfc502", "input": "Sera were collected at days 46 ( b ) and 74 ( c ) and pooled for each group for nAb against the 10 types in the vacccine.", "output": [ "method" ] }, { "id": "task1163-a72aead7007745c68f0a9dc4546ac3ef", "input": "Plant-derived oral vaccines are potentially useful in combating viral infections involving mucosal immunity.", "output": [ "background" ] }, { "id": "task1163-7a31ee8c0d5d4d1bade892ce7239a588", "input": "the virus could also possibly be transmitted by aerosol contact with conjunctiva and cause infection II ( 7 ).", "output": [ "background" ] }, { "id": "task1163-8831ba9219ea49089df6b49bffc51e99", "input": "Secondly , it compares the subjective perceptions of those nurses to those held by nurses who worked through historical epidemics of unknown or contested epidemiology.", "output": [ "purpose" ] }, { "id": "task1163-49159a91fd134d06a3e1809ca4e5193a", "input": "which could bind the HR1 or HR2 region of fusion protein , respectively.", "output": [ "method" ] }, { "id": "task1163-cfe3607b801f4448ad98ce2f15d22155", "input": "( A ) In-hospital mortality rates of ARDS over the study period 1997-2011 ; ( B ) Age-specific in-hospital mortality rates of ARDS.", "output": [ "finding" ] }, { "id": "task1163-9252e5511ffc42d48242c4b0da2404d7", "input": "The periostin concentration of IS supernatants was measured by enzyme-linked immunosorbent assay.", "output": [ "method" ] }, { "id": "task1163-d5ff550b4e684b4c84725902aed40f4e", "input": "inhibits its fusion with the virus.", "output": [ "background" ] }, { "id": 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the same indoor environment at different times.", "output": [ "method" ] }, { "id": "task1163-55c27867a08f44998dd37a9480e61edd", "input": "From these , FHTVTVNTL and IELAGTLTL peptides were shown to have 100 % conservancy.", "output": [ "finding" ] }, { "id": "task1163-e1e3870b266747cdb6c6cedbff34e9bb", "input": "Transmissible gastroenteritis virus ( TGEV ) is an economically significant coronavirus that can cause severe diarrhea in pigs.", "output": [ "background" ] }, { "id": "task1163-4c974ca3661b4507ae9588c8f42ba58d", "input": "Cells devoid of heparan sulfate were not able to mediate henipavirus trans-infection and showed reduced permissivity to infection.", "output": [ "finding" ] }, { "id": "task1163-be3ff15c9d6e46faa6558ccf7ccd650a", "input": "However , the virus could mutate to have increased interhuman transmissibility , increasing its pandemic potential.", "output": [ "finding" ] }, { "id": "task1163-49c750adfaf3464786a77ec123663b42", "input": "Limiting the number of contacts and hospital visits are also important factors to decrease the spread of infection.", "output": [ "finding" ] }, { "id": "task1163-25ced6a7eaa940d690034b9c565509d1", "input": "and demonstrate use of the pipeline in the analysis of 237 clinical samples comprising more than 1.1 billion sequences.", "output": [ "purpose" ] }, { "id": "task1163-3dd8de25bd86446f999742c0778982b1", "input": "Cytokines levels were measured in sera using enzyme-linked immunosorbent assay 61 ( ELISA ).", "output": [ "method" ] }, { "id": "task1163-884b38ffb40d45f7ac62c931083a8f63", "input": "samples positive for picornaviruses were further characterized by sequence analysis.", "output": [ "method" ] }, { "id": "task1163-61b616eaf81544b6a36826fc6eac873b", "input": "including a superantigen response , direct invasion by an infectious etiology or an autoimmune phenomenon.", "output": [ "background" ] }, { "id": "task1163-01bb8a6abcc0478db3f03d3db70d467c", "input": "leaving the vast majority of people with no effective means of prevention or treatment.", "output": [ "background" ] }, { "id": "task1163-36784fa495b740fe8993dbbd54fdb8c4", "input": "Scientists have identified different components of banaba to be responsible for its activity.", "output": [ "background" ] }, { "id": "task1163-3a3d657f8eec4e338004fd6237499c85", "input": "Korea 's reputation regarding infectious disease response had been tarnished by systematic problems and the absence of disaster management and communication capacity.", "output": [ "background" ] }, { "id": "task1163-0a8b51e46ced4dc5be5a68addc5fe574", "input": "and temperature ( typically room temperature ).", "output": [ "finding" ] }, { "id": "task1163-cdff1bae77c04289a8d22e665d062ff2", "input": "The form is designed to be completed electronically and stored electronically.", "output": [ "method" ] }, { "id": "task1163-52702fa624ab4749ad3303aadf4b6f60", "input": "Herein , we show that ligand activation of PPARA directly upregulates the long non-coding RNA gene Gm15441 through binding sites within its promoter.", "output": [ "background" ] }, { "id": "task1163-4e75c17cf344457c8717ae28abc5a18f", "input": "Evaluation of the assay with collected human samples showed no significant difference in mean optical density values of immunofluorescence-classified HCoV-NL63-positive and HCoV-NL63-negative samples ( F ( 1 , 215 ) = 0.437 , p = 0.509 ).", "output": [ "finding" ] }, { "id": "task1163-1644c1bfca184a4bb2b929f7d716aaf2", "input": "We emphasize on the virus-human host interplay and highlight existing knowledge gaps that needs further studies.", "output": [ "method" ] }, { "id": "task1163-40a012af309c4829b9982fb006f31111", "input": "exerted any effects on IFN-induced antiviral responses.", "output": [ "purpose" ] }, { "id": "task1163-184848acaa3d4a78a56648e6b21cca5e", "input": "FIGURE 4.", "output": [ "finding" ] }, { "id": "task1163-39dcac2015484ce39ce0ee48ca2ef30d", "input": "In RNA viruses , an observed correlation between mutation rate and virulence has led many to argue that their extremely high mutation rates are advantageous because they may allow for increased adaptability.", "output": [ "background" ] }, { "id": "task1163-3896495b7b484688ace0116944d8716c", "input": "DCL formation can be performed in the presence ( adaptive ) or in the absence ( pre-equilibrated ) of the protein target.", "output": [ "background" ] }, { "id": "task1163-ed6ac43665d946d79b786d59211d7d59", "input": "We describe recent advances and discuss future directions in reagent development for studying DUBs.", "output": [ "purpose" ] }, { "id": "task1163-0cfdbdbc1d294a1382fd24bb337a3d92", "input": "The physiological and pharmacological role of nucleic acids structures folded into the non canonical Gquadruplex conformation have recently emerged.", "output": [ "background" ] }, { "id": "task1163-589d0937215c4b0e910ae062009b0331", "input": "> 21 years of age.", "output": [ "method" ] }, { "id": "task1163-eddf0e712a124df6adc7991d2a7ddbe8", "input": "The approach of this timely review considers the current literature that is focused on the interface nanostructure/cell-wall microorganism to understand the annihilation mechanism.", "output": [ "background" ] }, { "id": "task1163-b638aaa9a6cd4f09a8d18463a3552236", "input": "In the current study , we explored whether the ORF4a protein of HCoV-229E has similar functions.", "output": [ "purpose" ] }, { "id": "task1163-0b004043aa71417d8d5817e2d2b53466", "input": "Introduction of the N - ( 4-phenoxyphenyl ) acetamide side chain at N 3 increased their potency and widened activity spectrum.", "output": [ "finding" ] }, { "id": "task1163-ffd01aab956d4cd3b97e7b8ba943a432", "input": "This review summarizes progress and challenges in the repurposing of approved drugs as host-targeted broad-spectrum agents for the treatment of intracellular pathogens.", "output": [ "purpose" ] }, { "id": "task1163-a7df80f9ed854527956a8fa500b34957", "input": "Further studies showed that GW3965 exerted its inhibitory effects on virus entry and replication.", "output": [ "finding" ] }, { "id": "task1163-6d4fdf9f04e84c00b943b185afe53893", "input": "We pooled data using random-effects meta-analyses to estimate the prevalence of specific mental health problems.", "output": [ "method" ] }, { "id": "task1163-c11885b73553464b984c1ccef6b51095", "input": "The predominant mechanism for rotavirus inhibition of the IFN response is likely both rotavirus strain-specifi c and cell type-specifi c.", "output": [ "background" ] }, { "id": "task1163-ebdc00b10da845c1b03645199e902e52", "input": "Objectives To investigate the occurrence of respiratory pathogens in samples from children with and without respiratory symptoms and to identify whether age and / or coinfections modify the impact of respiratory pathogens on symptoms.", "output": [ "purpose" ] }, { "id": "task1163-164b8934419d40f0a018f57c111aa0f1", "input": "We compared quantitative parameters with the qualitative evaluation of ciliary beat pattern in patients in whom the diagnosis of PCD was confirmed or excluded.", "output": [ "purpose" ] }, { "id": "task1163-7d602cc610854c19ba844953d06f621a", "input": "prognosis and therapeutic monitoring of diseases continues in earnest despite dwindling success at finding novel reliable markers.", "output": [ "background" ] }, { "id": "task1163-06747edba6f047b2bfd279585a084af9", "input": "The method is used to examine the similarity of different sequences by calculating the distances between them.", "output": [ "method" ] }, { "id": "task1163-a38a47ee76c0414b8e7948c539f68c60", "input": "Induced sputum of participants was processed and tested for thirteen viruses and bacteria.", "output": [ "method" ] }, { "id": "task1163-db1f27fb401841d68ee6c08bb548f695", "input": "Electrical parameters were recorded.", "output": [ "method" ] }, { "id": "task1163-247f0fb96f824ff6a08ed1b2acb11104", "input": "However , there are many unknowns about its epidemiology.", "output": [ "background" ] }, { "id": "task1163-6e923532de8d491790a495822272aaa4", "input": "and its potential for growth as globalization expands.", "output": [ "purpose" ] }, { "id": "task1163-5f92e358b6cc4f1c934a88c27a773972", "input": "The topological and electrostatic differences between the two protease binding sites also help explain the selectivity of non-covalent PLpro inhibitors.", "output": [ "finding" ] }, { "id": "task1163-0990dba6621840f89c694c1fc33832f5", "input": "Sensitivity of the two transmission pathways were compared with respect to the epidemic growth rate.", "output": [ "method" ] }, { "id": "task1163-a1c51f1d7a5342eba3b4d69bc93d9987", "input": "The GFP tag enables a relatively quick confirmation of antigen expression in plant cells by fluorescent microscopy.", "output": [ "finding" ] }, { "id": "task1163-d7f7a853779849ba893d2e35de00a3e8", "input": "Mortality within 30 days after the date of admission was calculated and risk factors were identified using logistic regression models.", "output": [ "method" ] }, { "id": "task1163-de31bc97a9e348fa8a2d376e5d99a4e3", "input": "This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization.", "output": [ "purpose" ] }, { "id": "task1163-16718964405447c2ba85fae09b7ab8d2", "input": "and CA3 and CA1 pyramidal cells were examined for spine density and morphology.", "output": [ "method" ] }, { "id": "task1163-8ff6515c5d1b40ed832343b506d22990", "input": "IM2 and Sulfolobus acidocaldarius DSM 639 ).", "output": [ "purpose" ] }, { "id": "task1163-808ea3bd885d4dabad84c112e95106f7", "input": "We describe four members of a family with autosomal dominant inheritance of a similar phenotype.", "output": [ "purpose" ] }, { "id": "task1163-593d800ff18b4f7e8533a73417caa873", "input": "Aminoacylated tRNAs were purified by reversed-phase HPLC on an RP-18 HPLC column ( 250 mm × 10.5 mm , Merck ) equilibrated with buffer ( 20 mM ammonium acetate , pH 5.0 , 10 mM magnesium acetate , 400 mM NaCl ) using a gradient of 0 % -15 % ) ethanol.", "output": [ "method" ] }, { "id": "task1163-77030ca17d904af6a1cd1759ff3a5f24", "input": "at the N-terminus of AP3 form a hook-like structure to stabilize interaction between AP3 and NHR helices.", "output": [ "finding" ] }, { "id": "task1163-291f00008177450abf75ba775d23654c", "input": "but have not achieved widespread acceptance for use in humans due to their low immunogenicity in early clinical studies.", "output": [ "background" ] }, { "id": "task1163-dfb823bbae334001a2cad75f774db4e2", "input": "29 Background : Our understanding of the corona virus disease 2019 ( COVID-19 ) continues to 30 evolve.", "output": [ "background" ] }, { "id": "task1163-8b985b6f82be443ab07029e54ae3e021", "input": "Transmissible gastroenteritis virus ( TGEV ) and porcine epidemic diarrhea virus ( PEDV ) are major etiological agents of diarrhea and death in piglets.", "output": [ "background" ] }, { "id": "task1163-37da53060d94474cb869db7fd018e53e", "input": "we discuss the conservation of CNPase in various organisms.", "output": [ "finding" ] }, { "id": "task1163-11d0645fc8794fd18c234cf004c2905e", "input": "and the role global change could have played in these variations.", "output": [ "purpose" ] }, { "id": "task1163-b71affff933f4eb2b9fe31a04c624f56", "input": "using a simple statistical model.", "output": [ "purpose" ] }, { "id": "task1163-f77b39bb9be4454f8ef132b9c884bd2a", "input": "Purpose : Ebola virus ( EBOV ) is such kind of virus which is responsible for 23,825 cases and 9675 deaths worldwide only in 2014 and with an average diseases fatality rate between 25 % and 90 %.", "output": [ "purpose" ] }, { "id": "task1163-bcb1b8a7f3fc410da173a1149f56ebda", "input": "This study aims to assess the possible role of some major domestic livestock species as intermediate hosts of HCoV-NL63.", "output": [ "purpose" ] }, { "id": "task1163-ffefeb8b31c14540ac0c4ecc55faa4dd", "input": "The aim of this study was to elucidate the mbrABCD-related bacitracin resistance mechanism of S. mutans.", "output": [ "purpose" ] }, { "id": "task1163-491e4db972ee4072a1ddab57038f9fdf", "input": "occupant density , and ventilation rate.", "output": [ "method" ] }, { "id": "task1163-19da5cda7fb14f1a959f4c35c4c87239", "input": "Background : Middle East Respiratory Syndrome ( MERS ) is a respiratory disease caused by a novel coronavirus that was identified in 2012 in Saudi Arabia.", "output": [ "background" ] }, { "id": "task1163-c19503efb4604b3b86aede61a410d4e2", "input": "this domain is proposed to have nucleotidylation activity.", "output": [ "background" ] }, { "id": "task1163-36628f6e6c0e4b2992be2ce40231c851", "input": "This chapter describes the use of an immunoprecipitation approach with Fc-tagged viral spike proteins followed by mass spectrometry to identify and characterize the receptor for the Middle East respiratory syndrome coronavirus.", "output": [ "purpose" ] }, { "id": "task1163-767e48e83ca7497ebb2fd45e22a704c3", "input": "mental health , and dementia-attract little attention in the public health curriculum and even less from the funding community.", "output": [ "background" ] }, { "id": "task1163-9e579e9604694e49b255f5407fbe4003", "input": "whereas pre-treatment of target cells had no effect.", "output": [ "finding" ] }, { "id": "task1163-85de459155c34e74a88616158f00fa90", "input": "while a recent developed multi-component Eulerian-Lagrangian approach was used to address the effects of inhomogeneous temperature and humidity fields on droplet evaporation.", "output": [ "method" ] }, { "id": "task1163-220268788c0c470094c0ca8ee552ea4f", "input": "In this study , we built a predictive model based on the cumulative trend of new cases and deaths for the top five provinces.", "output": [ "purpose" ] }, { "id": "task1163-f65b4d18d4074affb25d1c5628a94ca7", "input": "Fecal ( n = 28 ) and nasal ( n = 8 ) samples from diarrheic calves were tested for the presence of BCoV by both the PanCoV-RT-PCR and a specific BCoV-RT-PCR assays.", "output": [ "method" ] }, { "id": "task1163-6f0aaa7a0d5845f9933f95b512236cb2", "input": "( ii ) 600 sera received before April 2009 and randomly selected from in-patients were tested by a standard hemagglutination inhibition assay for antibody to the novel H1N1sw virus.", "output": [ "method" ] }, { "id": "task1163-2b47e3bb9bf04b569f02a5ec12577f83", "input": "The findings of epidemiological and virological studies prompted us to hypothesize that the human gastrointestinal tract could serve as an alternative route to acquire MERS-CoV infection.", "output": [ "purpose" ] }, { "id": "task1163-948f8147e8e7497ebc6b94d242b97b1e", "input": "Animals : Twenty-four client-owned cats with histopathologic confirmation of neurologic FIP.", "output": [ "purpose" ] }, { "id": "task1163-a8088046a44147f7963771e2da22d086", "input": "Aliquots of centrifuged and filtered stools were added to the mucosal or serosal side of human jejunum obtained from patients undergoing surgery and mounted in Ussing chambers.", "output": [ "method" ] }, { "id": "task1163-1a7395f56ff1431697de734d4db3be78", "input": "crowding , and patients remaining in the emergency department for many days.", "output": [ "background" ] }, { "id": "task1163-8ca55562f8734439a575a5c6b30c388b", "input": "In this study , we propose a novel numerical vector based on only primary sequences of organism to build their phylogeny.", "output": [ "purpose" ] }, { "id": "task1163-ebf071cf75434229a05fe6150846ef6b", "input": "Monoclonal antibodies ( mAb ) with specificities for leukocyte subsets and major histocompatibility complex ( MHC ) antigens were used to characterize IFNa producer cells.", "output": [ "method" ] }, { "id": "task1163-d994ef50f0c2422fa1f2ea6f1c7b8137", "input": "A lack of CCAAT box was observed in both bats.", "output": [ "finding" ] }, { "id": "task1163-ccccd63bd51847cd92c85fc198bd4fa8", "input": "TNF-α and IL-10 for their associations with SARS.", "output": [ "method" ] }, { "id": "task1163-76eafc463f7a452681c7408ff6b953ac", "input": "These problems are compounded by a global nursing shortage.", "output": [ "finding" ] }, { "id": "task1163-79c546146e8d447d822467003daa531a", "input": "Comparisons were made between patients who tested positive for the virus ( cases ) and those testing negative ( controls ).", "output": [ "method" ] }, { "id": "task1163-a19978ab2c924ace909d9c0af61559f7", "input": "By using this workflow , we purified ten targeted proteins from the sera of patients with various types of advanced stage ( stage III-IV ) cancers.", "output": [ "method" ] }, { "id": "task1163-73d48444e44549e28b857559ce2cabde", "input": "Advances in Next-Generation Sequencing ( NGS ) technologies and rapid development of bioinformatics and computational tools offer new opportunities for EID surveillance in quality and in scale.", "output": [ "background" ] }, { "id": "task1163-c3aa20b769844cfa914c87c8b88fb76f", "input": "An exposure to bats was defined as a bite or scratch from a bat or circumstances such as direct skin contact with a bat , bat urine or guano.", "output": [ "method" ] }, { "id": "task1163-2c802ebf2c06422ab00e1ac56053d0af", "input": "and 409 ( 24 % ) with viruses only.", "output": [ "finding" ] }, { "id": "task1163-0059069b111649c2bcd623727b478b91", "input": "consisting of 133 CAI and 76 HAI dogs , were studied.", "output": [ "method" ] }, { "id": "task1163-1d10100e28064f4fb74a8837b6df0b93", "input": "the findings strongly suggest that there is a causal relationship between allergen exposure in the home and asthma.", "output": [ "background" ] }, { "id": "task1163-ae68244a08604aa38194994e39fbdcb6", "input": "MERS-CoV and HCoV-OC43 ( Table 1 ).", "output": [ "background" ] }, { "id": "task1163-ddc3cc8d2aef489c89b83e42246cd6ca", "input": "vaccination of chicks with imported vaccines fails to protect them from IBV infections in Taiwan.", "output": [ "background" ] }, { "id": "task1163-a69f14ac81874fb5866e1ff14268abf2", "input": "some of which have serious and even lethal consequences.", "output": [ "background" ] }, { "id": "task1163-645ebab0e0c5499ebfd0db91e18cfddf", "input": "Importantly , inoculation of 2-day-old suckling mice with a plasmid expressing sIFITM3 conferred protection against lethal challenge with FMDV.", "output": [ "finding" ] }, { "id": "task1163-a841226c7843465ba0d4eedd2c6b96c8", "input": "incorporating internal and external factors concerning the present evaluation methods.", "output": [ "method" ] }, { "id": "task1163-c814484048a24c7188e60a0bfe3d58c1", "input": "new potential COVID-19 therapies are briefly reviewed.", "output": [ "purpose" ] }, { "id": "task1163-e9c8912196a1464ab4139bb98db307e4", "input": "The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules.", "output": [ "background" ] }, { "id": "task1163-e2e0869f3f8c4d678e25d66a51c966f1", "input": "The paper also describes components of 2-1-1 cost-benefıt analyses.", "output": [ "purpose" ] }, { "id": "task1163-02687269941242e7a8058021ccc9497b", "input": "Hantaviruses ( HVs ) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome ( HCPS ) in the Americas and hemorrhagic fever with renal syndrome ( HFRS ) in Eurasia.", "output": [ "background" ] }, { "id": "task1163-376d8c254276476bbc3ca3a64df63471", "input": "The policy of voluntary reporting abortion outbreaks to the Animal Health Service hindered the timely detection of the circulation of Q fever , and therefore early interventions.", "output": [ "background" ] }, { "id": "task1163-7890e942444c4c2e87f63b1f5478e2a1", "input": "However , the role of B cells and antibodies in KD pathogenesis remains unclear.", "output": [ "background" ] }, { "id": "task1163-24dc79a8ee554f599ba5bb80c171fbe3", "input": "the imperfect PSD switched rapidly to the upright position where the Ag + ions intercalated between C-C mismatches of dsDNAs at the top of each structure brought further from the electrode surface resulting in a significant electrochemical signal drop of the Ag + ions.", "output": [ "finding" ] }, { "id": "task1163-8a41005b667f40a4b1fe4b44f70ea75f", "input": "Using identical doses , MVTT-S induced lower levels ( ,2-3-fold ) of anti-SARS-CoV neutralizing antibodies ( Nabs ) than MVA-S through intramuscular inoculation.", "output": [ "finding" ] }, { "id": "task1163-ed8f773823b94c7a851b9146349dd8aa", "input": "The application of the immunoperoxidase ( IP ) plaque staining procedure ( IP test ) to the diagnosis of canine coronavirus ( CCV ) infection was investigated.", "output": [ "background" ] }, { "id": "task1163-149702982c8d475e93b967a06e6f1742", "input": "However , addition of surrounding sequences in Domain III abolished the speckle formation for TGEV nsp15 but not for MHV and SARS-CoV nsp15s.", "output": [ "finding" ] }, { "id": "task1163-b946b43121bf437096164d07377b4008", "input": "Background : Communicable disease outbreaks of novel or existing pathogens threaten human health around the globe.", "output": [ "background" ] }, { "id": "task1163-50a6ea0e1fde40e9a0df026e1b21f446", "input": "the IFN-I receptor and/or Ly49H.", "output": [ "purpose" ] }, { "id": "task1163-d477895c3e414e03a9389eb782216934", "input": "and the association of radiologic findings with mortality of patients was evaluated.", "output": [ "method" ] }, { "id": "task1163-7d84d0313b6c4afaaf197735af21900d", "input": "This can be regarded as part of the recovery phase of disaster management.", "output": [ "background" ] }, { "id": "task1163-a4a81905a1cf42bc95cc0a74a7fbc120", "input": "with 255 ( 66 · 9 % ) of 381 positive cases in this age group.", "output": [ "finding" ] }, { "id": "task1163-3384b61528284b368a91fae4e7890bca", "input": "In this study we identified the receptorbinding domain ( RBD ) of the spike of the prototype IBV strain M41.", "output": [ "purpose" ] }, { "id": "task1163-d64c6734499f4400b36053e35ade586b", "input": "Molecular diagnostic testing was performed on nasal washes for common respiratory viruses and pathogenic bacteria.", "output": [ "method" ] }, { "id": "task1163-cc01d787f0ae48d8a9997c7bb53878f1", "input": "and an archaea-specific subunit annotated as DnaG.", "output": [ "background" ] }, { "id": "task1163-a928341d67244fea9f96c9cb4c069e16", "input": "We will further shed light on how the combination of viral vector-based vaccination with T-cell supporting strategies will bring this strategy to the next level.", "output": [ "purpose" ] }, { "id": "task1163-e19ab027c5014bc0a7d1ff6b36c71c47", "input": "Compounds 5 , 12 , 14 and 22 also showed comparable MIC to karanjin.", "output": [ "finding" ] }, { "id": "task1163-08df12237f7c4e47bf2fee2c620c7be0", "input": "Understanding and improving nurses ' working conditions can potentially decrease the incidence of many infectious diseases.", "output": [ "finding" ] }, { "id": "task1163-c9bc5dc497a14a6ab3fbbc70afe279f7", "input": "or a combination of both.", "output": [ "finding" ] }, { "id": "task1163-b67f9236f2604d5991705f2ed7f9afa3", "input": "while suggesting its ability to prevent Herpes and Dengue infections.", "output": [ "finding" ] }, { "id": "task1163-061af4096c154f77ac34482cdae127d3", "input": "and APACHE II scores were observed between the two groups at admission to the Intensive Care Unit.", "output": [ "finding" ] }, { "id": "task1163-2a330a7025c74b118d5a406e183d6aba", "input": "Four major protein species were resolved by electrophoresis and many of their properties were deduced from digestion studies using proteolytic enzymes.", "output": [ "method" ] }, { "id": "task1163-002e8a43dea94f6dab222c3165b65c3b", "input": "Exposure to MERS-CoV via direct contact with animals or dairy products seems unlikely for the two Dutch cases.", "output": [ "finding" ] }, { "id": "task1163-a166927be13f4116a527592e566d1181", "input": "Purpose Antigens were conjugated on the surface of Ntrimethylaminoethylmethacrylate chitosan ( TMC ) nanoparticles to induce systemic and mucosal immune responses after nasal immunization.", "output": [ "purpose" ] }, { "id": "task1163-48eada1fef03410eaaac02ee959eb923", "input": "programs and web servers and their applications are reviewed in this paper.", "output": [ "purpose" ] }, { "id": "task1163-7edf81ef07ad4686ba1e796b29c2e0c7", "input": "which were observed at the level of the protein and/or mRNA.", "output": [ "finding" ] }, { "id": "task1163-dcbb8fe9deda4875843ba605c44f0890", "input": "so as to explore the effective mode of clinical psychological intervention in acute patients under isolation environment.", "output": [ "purpose" ] }, { "id": "task1163-ca5df89c7af54b1ba43dd085ec8816ff", "input": "Therefore , HMBS and HPRT1 are recommended as the two most stable reference genes for the normalization of gene expression data at different stages of eggshell formation in brown-egg laying hens.", "output": [ "finding" ] }, { "id": "task1163-ded1f8b505cd4851927c60437f6bbd49", "input": "An international collaborative effort through the World Health Organization ( WHO ) has helped to identify the aetiological agent about 1 month after the onset of the epidemic.", "output": [ "background" ] }, { "id": "task1163-102cac529c9e40589464f3ab698ba398", "input": "Here , we review recent progress in understanding the contributions of LN stromal cells to immune senescence.", "output": [ "purpose" ] }, { "id": "task1163-901409690e1546a7ae1e6b3c916cc42f", "input": "it had enhanced replication and pathogenesis in mice.", "output": [ "finding" ] }, { "id": "task1163-ef4cb01f2fce424bb4277cd10a3063af", "input": "RSV F or EBV gp350 protein was secreted from infected cells.", "output": [ "method" ] }, { "id": "task1163-5a4a07cddc06406d8bf9cf1cdca79439", "input": "Here we show that ؊ 1 PRF occurs at a similar site during translation of the TMEV genome.", "output": [ "finding" ] }, { "id": "task1163-6da4345ba2bf4b06a622eb7c39240e32", "input": "serum samples collected from patients during an outbreak of HCoV-OC43 infection and previously identified as positive by HCoV-OC43 whole N ELISA were screened resulting in 100 % diagnosis agreement between the testing methods.", "output": [ "finding" ] }, { "id": "task1163-20618647bdc0450889ad7f6d78a5a01f", "input": "clinical upper respiratory tract infection ( URTI ) in university students.", "output": [ "purpose" ] }, { "id": "task1163-ff3b84b814d048c09bb93bf033b86bf3", "input": "In this paper we describe the first real-time syndromic surveillance system that conducts integrated spatio-temporal analysis of data from a national network of veterinary premises for the early detection of disease outbreaks in small animals.", "output": [ "purpose" ] }, { "id": "task1163-04ea9422473a4f03b90ff1f6bdbfcb23", "input": "glucosamine , and orthophosphate to analyze virion structural proteins.", "output": [ "background" ] }, { "id": "task1163-f1315c4de1414a8eb437387b088e0c8d", "input": "Invasive wildlife species have the potential to act as additional host and vector species for infectious diseases.", "output": [ "background" ] }, { "id": "task1163-2c0154c313f541f8b13072bf12cc834f", "input": "Older age-groups perceived the risk for coronavirus infection as lower ( all adjusted Odd Ratio 's ( aOR ) ≤ .058 ).", "output": [ "finding" ] }, { "id": "task1163-22ac186b9f654a1a81f63e921f8dd9ea", "input": "initiated by the binding of the spike protein to the human ACE2.", "output": [ "background" ] }, { "id": "task1163-2c8c21354e4544eea6a2894914804711", "input": "outbreak investigation , and the diagnosis of infectious diseases.", "output": [ "background" ] }, { "id": "task1163-7ac92978c9fd43eda339017ab53136a4", "input": "The aim of this study was to evaluate the antibodies against Stx2 obtained from egg yolks of laying hens immunized with a recombinant Stx2B subunit.", "output": [ "purpose" ] }, { "id": "task1163-da5f32eeea15478d9d17a925b83b3c2f", "input": "antitumor and antibiotic activities using a data set of 1804 compounds from PubChem.", "output": [ "method" ] }, { "id": "task1163-478b114d47de424298b2ffe8e69f6313", "input": "but the signifi cance remains unclear.", "output": [ "finding" ] }, { "id": "task1163-467b16691bb44d17809ecfed762fd0f9", "input": "each approved in the United States and many other countries for the prevention and treatment of influenza.", "output": [ "finding" ] }, { "id": "task1163-4ca279de2ab44ec0b246cff21ec10343", "input": "In the present work , peptide-lipid interactions of C8 with dimyristoyl phosphatidylcholine liposomes are investigated using electron spin resonance spectroscopy of spin-labelled lipids.", "output": [ "method" ] }, { "id": "task1163-62c118fb924a4f4fa6563bf6929efacd", "input": "Further , studies on HSV1-infected APOE-transgenic mice have shown that APOE-e4 animals display a greater potential for viral damage.", "output": [ "background" ] }, { "id": "task1163-2a49b92b13034318b380fb73932ee790", "input": "Expression vectors were constructed to allow cloning in all three reading frames.", "output": [ "method" ] }, { "id": "task1163-43bccff577124358b33d3d4af719bdf7", "input": "Morphological studies use optical and electronic microscopes to determine the physical damage on the cell-wall and the possible cell lysis that confirms the viability and microorganism death.", "output": [ "background" ] }, { "id": "task1163-290a0c491f224d30bd796bc2debaa239", "input": "As reporter genes , we used the IucZ gene and a number of genes encoding coronavirus structural proteins : among others the genes encoding glycoproteins with N-terminal signal sequences.", "output": [ "method" ] }, { "id": "task1163-ddef3a18abe44735a06d01c4e3b37557", "input": "respectively ( 27 ) ( 28 ).", "output": [ "background" ] }, { "id": "task1163-622b3f47ecda4dda9345ea3142e033ca", "input": "participants ' acceptance of a facemask to prevent influenza in the presence of an experimenter with flu-like symptoms was recorded.", "output": [ "method" ] }, { "id": "task1163-97625f53db4549549b70ca5a5f97f473", "input": "The present study investigated the expression of type I interferon ( IFN-I ) pathway members in CDV-induced cerebellar lesions to gain an insight into their role in lesion development.", "output": [ "purpose" ] }, { "id": "task1163-7d7b5c80009f4418ab12157e037b1ec5", "input": "thereby exposing their axon terminals to factors circulating in the blood or released locally from invading trypanosomes or from macrophages or cytotoxic T-cells.", "output": [ "finding" ] }, { "id": "task1163-f7525a3d85c04da8be6aac151ac8035d", "input": "In this study an in vitro assay was optimized to detect feline proliferating lymphocytes as an assessment for the cell-mediated immune response.", "output": [ "purpose" ] }, { "id": "task1163-434ece98bf994e8b9b676b5b064ae614", "input": "and other vaccines and antiviral drugs are under development.", "output": [ "finding" ] }, { "id": "task1163-bbea8ba8551f419ab8b4f8f292032607", "input": "a membraneassociated enzyme present at high levels in the tetrapod myelin sheath.", "output": [ "method" ] }, { "id": "task1163-c1ba550a9d8445e985b953ef1a57bbae", "input": "using serological data , an association between systemic infections and cognitive decline , with HSV1 particularly implicated.", "output": [ "finding" ] }, { "id": "task1163-6bc23a18226a4e4ca7c765092b95062b", "input": "if any , is subsequently purified by immobilized metal affinity chromatography ( IMAC ).", "output": [ "method" ] }, { "id": "task1163-1e56e8e1a04442bcac496e2062d52c3a", "input": "followed by active immunization with HBsAg-HBsAb ( mYIC ) was evaluated.", "output": [ "method" ] }, { "id": "task1163-53e7faae5c9644e3ba803072a2b55af1", "input": "while animals with low titers of IgG1 ( < 1024 ) were mostly infected with BCoV.", "output": [ "finding" ] }, { "id": "task1163-2552771f19e743f0920e4d6c55e9d4f5", "input": "and 13 for other respiratory viruses.", "output": [ "method" ] }, { "id": "task1163-b29fdacec25c4f16942cb8268d59a79b", "input": "many influenza A infections are afebrile.", "output": [ "finding" ] }, { "id": "task1163-f3dfcc0621044b8a899f69e7eccaf7e7", "input": "In contrast , LYM % was lower than 20 % in severe cases.", "output": [ "finding" ] }, { "id": "task1163-1842bbc7d5eb4b409aa557c5712deadc", "input": "Inverse correlations between promoter methylation and activity were described for the first time in this system and initiated active research in the field of DNA methylation and epigenetics.", "output": [ "background" ] }, { "id": "task1163-078adb8ae7fb4475a4050ea0c522cd66", "input": "grubii that covers a considerable digit of the world population through implementing computational vaccinology approach.", "output": [ "purpose" ] }, { "id": "task1163-17bb55878ba4482a9d24be6d381549b0", "input": "One of these structures was similar to the so-called antiviral stress granules ( avSGs ) formed by an infection with IFN-inducing viruses whose C proteins were knocked-out or mutated.", "output": [ "finding" ] }, { "id": "task1163-08dd1764cd7f4a359cc5f2f794236247", "input": "Usually , a cosolvent such as dimethyl sulfoxide ( DMSO ) is used to maintain products and building blocks in solution.", "output": [ "background" ] }, { "id": "task1163-f4d09f67c66743e6b5dd8cf10723a0ee", "input": "which results in fusion inhibition.", "output": [ "purpose" ] }, { "id": "task1163-2e5b49928c074434b56314870ccacd58", "input": "The students performed simulations of contaminated PPE removal with fluorescent lotion on gloves and were assessed for correct PPE technique and skin and/or clothing contamination.", "output": [ "method" ] }, { "id": "task1163-66cb29097ab141048509416d7da36ae6", "input": "Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer ( mCRC ) randomized to FOLFIRI with/without cetuximab.", "output": [ "background" ] }, { "id": "task1163-44dc749ad5944208b22469bd7f993be8", "input": "Quantitative RT-PCR was used to detect 1b gene of HCoV-NL63.", "output": [ "method" ] }, { "id": "task1163-72e0780b3a474cc5ac4a4ef7c7a7c596", "input": "and all experimental possibilities for a new vaccine development against a pathogen should be studied in detail.", "output": [ "background" ] }, { "id": "task1163-7536a2300bd4484f822e84c895bece42", "input": "particularly in priming high-level antigenspecific antibody responses.", "output": [ "background" ] }, { "id": "task1163-423e7c0eaff34d7599a40962b75ef693", "input": "whereas Type 2 energy transfer produces cytotoxic singlet oxygen.", "output": [ "finding" ] }, { "id": "task1163-17550dd5107a41f8944ee6e4f4961627", "input": "or to kittens before introduction in a potentially contaminated environment.", "output": [ "finding" ] }, { "id": "task1163-bfeb73ed1ed04e2cbb71aaccf57e2557", "input": "This review examines the evidence regarding toilet plume bioaerosol generation and infectious disease transmission.", "output": [ "purpose" ] }, { "id": "task1163-caae963bc6b9420e9ef5412a72b620b2", "input": "In this systematic review we aimed to summarise current knowledge regarding patterns of human-livestock contacts and their role in micro-organism transmission.", "output": [ "purpose" ] }, { "id": "task1163-7aa0d508adf74c65a44bce9004906d53", "input": "bacteria and atypical bacteria in a sample of Egyptian children presenting with symptoms of acute respiratory tract infection.", "output": [ "purpose" ] }, { "id": "task1163-4b32cd8f3db7406aa0b957f7f32c4b0b", "input": "Results-Candidate pathogens were detected by MassTag PCR in 27 of the 44 ( 61 % ) specimens that previously were rated negative.", "output": [ "finding" ] }, { "id": "task1163-b80d0332758f4f1698b3e43520c16a39", "input": "public health authorities require evidence on the effectiveness of control measures such as thermal screening of arrivals at airports.", "output": [ "background" ] }, { "id": "task1163-056be4727e51421dbb9aa6cb713d27d5", "input": "Here , we complete a two-part controllability analysis of two protein networks : a host network representing the healthy cell state and an influenza A virus-host network representing the infected cell state.", "output": [ "method" ] }, { "id": "task1163-abf5b23ea8f943b2ad4975d5aa09a6cf", "input": "outperforming them all by quickly providing solutions of higher average quality in all the experimental cases.", "output": [ "finding" ] }, { "id": "task1163-4ab8eece3a954bd99de5b3ac403f2a93", "input": "The obtained sequences were analyzed by using ChromasPro version 1.7.4 ( Technelysium Pty Ltd , Australia ).", "output": [ "method" ] }, { "id": "task1163-bb3c6539de564bc0817cf53c2e075642", "input": "acidosis , impaired liver , and renal function at the time of admission exhibit more severe mortal progressions.", "output": [ "finding" ] }, { "id": "task1163-850ec1542c0e4f9683b095025d3b8d7d", "input": "and to validate the herd-level estimates against subsequent BTM testing.", "output": [ "purpose" ] }, { "id": "task1163-c8891b23396741b485626b953ee31aee", "input": "compared with controls , suggesting that rFeIFN stimulates antibody production.", "output": [ "finding" ] }, { "id": "task1163-a463c9802ec740209a656f822671b02f", "input": "Two groups of five dogs were experimentally inoculated with 50 and 100 third stage infective larvae ( L 3 ) of A. vasorum per kilogram of body weight.", "output": [ "method" ] }, { "id": "task1163-c2df0cbe4cdb46ddaec77251652078bc", "input": "A stable , full-length , infectious SHFV-LVR cDNA clone was constructed and a set of mutant infectious clones was generated each with the start codon of one of the minor structural proteins mutated.", "output": [ "method" ] }, { "id": "task1163-4f0d131a48444af78be5de11c6e4fd8d", "input": "less is known about co-detections and the resultant comparative symptoms and illness burden.", "output": [ "background" ] }, { "id": "task1163-ee5535a97559482493cf67035fc2dde1", "input": "recognition of the vesicle by the target membrane and fusion of the vesicle with the target membrane resulting in delivery of its contents.", "output": [ "background" ] }, { "id": "task1163-d61c59d0a5dd4a44be72bb04091e10e2", "input": "as well as mentioned novel agents currently in development.", "output": [ "purpose" ] }, { "id": "task1163-ef29839d35494ed29dccb587a30193db", "input": "To assess the impact of intensification of interferon administration and of the addition of amantadine on the efficacy and safety of standard anti-hepatitis C virus ( HCV ) treatment in HIV-infected patients.", "output": [ "purpose" ] }, { "id": "task1163-a148d4c3c5564ed7b1f396b719ee9de7", "input": "We concluded that the codon usage bias was weak and the translation selection was the main shaping factor in nuclear genes of these four cotton genomes and four subgenomes.", "output": [ "finding" ] }, { "id": "task1163-d47a47ae8b9e4c83a3197a7cfc5fc719", "input": "Autophagy is a key innate immune response to intracellular parasites that promotes their delivery to degradative lysosomes following detection in the cytosol or within damaged vacuoles.", "output": [ "background" ] }, { "id": "task1163-ad3630c96c294382b119ce7d13e6fda6", "input": "Methods : New York State hospitals with emergency departments having more than 1,000 visits annually were invited to participate ; 23 hospitals participated.", "output": [ "method" ] }, { "id": "task1163-70531d9ac77347f689628b4193313f20", "input": "We demonstrate statistically significant evidence for assortative contact patterns between animals of the same species.", "output": [ "finding" ] }, { "id": "task1163-7c261afa00e049a285760a6edf6423de", "input": "while the expression on tumor-infiltrating CD8 + T cells was low.", "output": [ "finding" ] }, { "id": "task1163-9d83bed3971c444daa347017579457d9", "input": "This study explored the application of a combined visible and thermal image processing approach that uses a CMOS camera equipped with IRT to remotely sense multiple vital signs and screen patients with suspected infectious diseases.", "output": [ "purpose" ] }, { "id": "task1163-316ff628bec444c7a9e03516eec925ef", "input": "F4/80 + macrophages are present in perivascular infiltrates close to and in contact with HSV-infected cells in areas of massive myelin loss.", "output": [ "finding" ] }, { "id": "task1163-f21fd29f04d541be8ef53771342dab43", "input": "smart bandages and tissue engineering.", "output": [ "background" ] }, { "id": "task1163-62af3d06dba5440888cd76c3083b7ef7", "input": "Newcastle disease ( ND ) is a contagious disease that affects most species of birds.", "output": [ "background" ] }, { "id": "task1163-dd8ffe5f044e4882854fd74326086c3c", "input": "The data suggest that SAT05f could be developed as a candidate medicament for the treatment of TLR7/9 activation-associated diseases by inhibiting TLR7/9 signaling pathways.", "output": [ "finding" ] }, { "id": "task1163-08f1a715526a453e98f9e09fac5c025d", "input": "complex and expensive flow cytometer.", "output": [ "method" ] }, { "id": "task1163-1bc6a050fdfd4b289da6c23063b4cedc", "input": "Objective : To compare the frequency of upper respiratory tract symptoms in individuals receiving E purpurea capsules and those receiving placebo to evaluate the preventive efficacy of echinacea.", "output": [ "purpose" ] }, { "id": "task1163-5754a5795f55495185860ab6fc01a035", "input": "Patient Enablement Instrument ( PEI ) and an overall satisfaction rating scale.", "output": [ "method" ] }, { "id": "task1163-45025847af204049b659dea7b12209d6", "input": "Another emerging technique is Fluorescence Activated Droplet Sorting ( FADS ) whereby selection does not rely on binding capture allowing evolution of a greater diversity of aptamer properties such as fluorescence or enzymatic activity.", "output": [ "background" ] }, { "id": "task1163-f1157504ed204a958fda2fa0f5dc2390", "input": "New World ( NW ) hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease.", "output": [ "background" ] }, { "id": "task1163-65d5c7af3f224624b6f3bcf4fed1c7a7", "input": "and studies in Asia are limited.", "output": [ "background" ] }, { "id": "task1163-628e350b4f0742dfba4c00e6182b31c6", "input": "Respiratory infectious diseases were the most significantly affected bio-functions in LBW newborns.", "output": [ "finding" ] }, { "id": "task1163-8f81aa5fb7eb430b964fc231e229cf9a", "input": "In humans , the mechanism that compensates MyD88 deficiency has not been elucidated.", "output": [ "background" ] }, { "id": "task1163-45be18affd324f348d52af6e7530975f", "input": "19 - , and 20-week-old fattening pigs.", "output": [ "method" ] }, { "id": "task1163-f30259438e2742409a5bad9b82c8a039", "input": "We have investigated the association between DC-SIGN genetic variants and risk of MTCT of HIV-1 among Zimbabwean infants and characterized the impact of the associated mutations on DC-SIGN expression and interaction with HIV-1.", "output": [ "purpose" ] }, { "id": "task1163-bdb2d2fee83f433da7f67591e2a85a66", "input": "The severe acute respiratory syndrome ( SARS ) pandemic in Toronto resulted in a large number of autopsies on its victims.", "output": [ "background" ] }, { "id": "task1163-e6820feab06e41ffb9500c614c5657d7", "input": "indicating that the two domains of CNPase form an elongated molecule.", "output": [ "finding" ] }, { "id": "task1163-82d2dcb681d748739bd14b739047565e", "input": "leading to a variety of backbone topologies.", "output": [ "background" ] }, { "id": "task1163-a7d0fec9075545c4b5410d67e5613d9e", "input": "An overview of different steps in recent drug discovery is presented to illuminate the links with the most recent advances in NMR methodology.", "output": [ "purpose" ] }, { "id": "task1163-46ef6ff837594cff8a58ed9c29ca7ae8", "input": "Two scenarios have been studied.", "output": [ "purpose" ] }, { "id": "task1163-b5cfee2dad7c418ebdbea3f18ffe859e", "input": "The major antibody isotype in external secretions is secretory immunoglobin A ( S-IgA ).", "output": [ "background" ] }, { "id": "task1163-6abbd503cbd44d1ab56dd8c6fbdd9094", "input": "bovine partetravirus and porcine partetravirus ( previously known as human parvovirus 4 , bovine hokovirus and porcine hokovirus respectively ).", "output": [ "background" ] }, { "id": "task1163-96945d2904c04cb98158bf53590ab59f", "input": "we will discuss these different properties of the N-protein in a consolidated manner.", "output": [ "method" ] }, { "id": "task1163-5698e2f0215a41cc888ef7fd50e8dd43", "input": "It may be conclude that infection by A. vasorum in dogs may cause a discrete anemia during the acute phase which is probably regenerative.", "output": [ "finding" ] }, { "id": "task1163-e960f806af39454db7819af4c9ae0e64", "input": "The necessary controls were included.", "output": [ "method" ] }, { "id": "task1163-86e15efe5cd24038ab72e143ff1df8b1", "input": "Up to now , although few complete nucleotide sequences of PHEV have been reported , they are not annotated.", "output": [ "background" ] }, { "id": "task1163-259bcf4c3c6d47d5928fd2e69883a71a", "input": "Namely , the use of `` omic '' technologies ( next generation sequencing , DNA , and protein microarrays ) for dissecting the underlying host response to infection at the molecular level ; optical imaging techniques ( flow cytometry and fluorescence microscopy ) for assessing cellular responses to infection ; and biophotonic imaging for visualising the infectious disease process.", "output": [ "purpose" ] }, { "id": "task1163-67848653d9a64a6eb633fd0360742a2d", "input": "a Ubl-specific protease ( Ulp1 ) was used to cleave small ubiquitin-like modifier ( SUMO ) fusion proteins.", "output": [ "purpose" ] }, { "id": "task1163-f62c1e97ab7a483ab0f22591cd9b1c84", "input": "2019 , and Jan 26 , 2020.", "output": [ "method" ] }, { "id": "task1163-f75576ad50bc42ceab2b9f3f2def9977", "input": "The purpose of this investigation was to enhance our understanding of EV-D68 epidemiology and clinical features.", "output": [ "purpose" ] }, { "id": "task1163-3934d4e2571b47c0a8ec6fcce6cc5116", "input": "as confirmed by an atomic force microscope and surface profiler.", "output": [ "method" ] }, { "id": "task1163-37d8e6adbd474cfd979eb2fbfe30249e", "input": "The objective of this study was to develop a symptom scoring system for use in clinical studies that differentiates children with cold symptoms who have an identifiable viral etiology for their upper respiratory tract infection ( URI ) from those in whom no virus is detected.", "output": [ "purpose" ] }, { "id": "task1163-cc180e4cc72943deabd8194d2cf4a223", "input": "precedent studies and other publications.", "output": [ "purpose" ] }, { "id": "task1163-96c2436e84734508af1e4670f73261dc", "input": "Laboratory testing identified 70 infections ( 46.7 per 100 URTIs ).", "output": [ "finding" ] }, { "id": "task1163-245bc354f287417aa30066ba0f841e5e", "input": "Background : Infectious disease surveillance is a process the product of which reflects both actual disease trends and public awareness of the disease.", "output": [ "background" ] }, { "id": "task1163-be0ab6c731b14a7f816fbd1f1eb3ea99", "input": "while the CTD conservation correlates with the presence of exosome.", "output": [ "finding" ] }, { "id": "task1163-a24f07f4793c4f46bc3a0b32affd4437", "input": "The present study investigates the association between the ABO and Rh ( D ) blood group status and WNV disease outcome.", "output": [ "purpose" ] }, { "id": "task1163-f99295a5dc2f4c19bb8f3d60067b12be", "input": "The cytoplasmic portion of the S glycoprotein contains four cysteine-rich amino acid clusters.", "output": [ "background" ] }, { "id": "task1163-2d455ca8461748b1afccddc90b8b6a1e", "input": "A strategy to prevent transmission in ophthalmology outpatient clinics adopted in all public hospitals in Hong Kong during the COVID-19 outbreak should serve as templates for other ophthalmologic practices ( 8 ).", "output": [ "background" ] }, { "id": "task1163-2c94102272e14af6b3194c804a3b8ae1", "input": "and suggest that the Tat-Egr-1-p300-GFAP axis likely contributes to Tat neurotoxicity and predisposes astrocytes to be an HIV-1 sanctuary in the CNS.", "output": [ "finding" ] }, { "id": "task1163-cc2b4fe5f4324cc2bec45202b641df49", "input": "the need for communication , information sharing and disclosure and onsite response were identified as key factors influencing effective infectious disease response.", "output": [ "finding" ] }, { "id": "task1163-918b467b9a314bd1950022488ebc9629", "input": "the biological activities , toxicology and phytochemistry of Lonicera japonica.", "output": [ "purpose" ] }, { "id": "task1163-51bd4997140445cda54e9a9cfe5f5436", "input": "directional mutation and other factors.", "output": [ "finding" ] }, { "id": "task1163-80fa4f7cee564d89aad5de020ebe5717", "input": "233 ( 1996 ) 1 ) is examined.", "output": [ "background" ] }, { "id": "task1163-dbdda03e7c6e4786b9583bdd796db19f", "input": "low-neurovirulence BeAn strain induced apoptosis in murine astrocytes.", "output": [ "purpose" ] }, { "id": "task1163-eb61e1b65ca24aad89e14c2a201ed416", "input": "after 24-48 h of incubation at 35ЊC.", "output": [ "finding" ] }, { "id": "task1163-9a915169f8134d05972cafbd0778dd06", "input": "China , respiratory manifestations of the disease have been observed.", "output": [ "background" ] }, { "id": "task1163-b0c961ff43e24a6ea628ead0ca4a2c5b", "input": "We adapted an existing national-scale metapopulation model to capture the spread of CoVID-19 in England and Wales.", "output": [ "purpose" ] }, { "id": "task1163-fe38c7426ce043a184ba7d2542d198c1", "input": "expressed in bacteria to produce Fab fragments and sequenced.", "output": [ "method" ] }, { "id": "task1163-d390cbf5b8e54ef7921203c042f7ed23", "input": "These results indicate that pAPN may be a functional receptor for PDCoV infection.", "output": [ "finding" ] }, { "id": "task1163-bb1c0335e98a4610be32d634b5edf4a8", "input": "However , it remains unclear at what time the critical exposure occurs ( ie , in infancy or later ) and what role allergen exposure has played in the increasing prevalence and severity of asthma.", "output": [ "background" ] }, { "id": "task1163-5b1065c3c2bf401fbbe6fdb24d7a9d89", "input": "In fact , reported cases of MERS-CoV often stem from outbreaks within the Middle Eastern countries or recent travel to the region ( 18 , 19 ).", "output": [ "background" ] }, { "id": "task1163-d97b5214414840ea81170b7ef391d7b4", "input": "pDCs are the major source of type I IFN ( IFN-I ) during MCMV infection.", "output": [ "background" ] }, { "id": "task1163-1c1cf8a94f51419f81ef59b80186def1", "input": "A Kappa coefficient test was used to assess the level of agreement of both assays.", "output": [ "method" ] }, { "id": "task1163-06ccb3c319f740488f4432c4d63da113", "input": "Recent trials suggest procalcitonin-based guidelines can reduce antibiotic use for respiratory infections.", "output": [ "background" ] }, { "id": "task1163-029af87b59ad480f8434a1bc0cf0b3d3", "input": "which is widely distributed throughout the world.", "output": [ "background" ] }, { "id": "task1163-8ac484794c95457c9830e1e3b2effdaa", "input": "For innate immunity , autophagy may assist in the delivery of viral nucleic acids to endosomal TLRs and also functions as a part of the TLR-or-PKR-downstream responses.", "output": [ "background" ] }, { "id": "task1163-63555a8be1ab461c92065c0ef7a02a14", "input": "In this study , we report the structures of different conformational states of the SARS-CoV S glycoprotein during virus entry.", "output": [ "purpose" ] }, { "id": "task1163-32c27d7069cc4ca8be74a01b74149ed9", "input": "together with parameter estimates from the current outbreak in China.", "output": [ "method" ] }, { "id": "task1163-b6b434aed3c74b3d91b7dfb29f3e24ed", "input": "Ten calves were inoculated intranasally with BVDV Type 1.", "output": [ "method" ] }, { "id": "task1163-72bc3bf986fa4e9ebf53b9703510e138", "input": "A better understanding of the pathogenesis of NDV will help us design efficient vaccines and novel anticancer strategies.", "output": [ "purpose" ] }, { "id": "task1163-c9d58c5d7ebe438c9f62156b9967aa38", "input": "in order to guide IPC in practice.", "output": [ "background" ] }, { "id": "task1163-02d322c906664564a6dc39430d602406", "input": "In this report , we present the results of a targeted surveillance study in different bat species in Hong Kong.", "output": [ "purpose" ] }, { "id": "task1163-06d8a23f368d4c2cb4a8183c7fbb3b4c", "input": "and we propose and discuss a new household-to-household reproduction number R H for it.", "output": [ "purpose" ] }, { "id": "task1163-94f52d3bf9bc4944b6461602f5a9bab1", "input": "The structure activity relationship revealed that the presence of electron withdrawing groups at para position of phenyl ring remarkably enhanced the antibacterial activity of synthesized compounds.", "output": [ "finding" ] }, { "id": "task1163-d0d3f1b428494590b4e3e043a7f97b3a", "input": "In this study , the possibility of transmission of BVDV from calves simultaneously subjected to acute BVDV and bovine coronavirus ( BCV ) infection was investigated.", "output": [ "purpose" ] }, { "id": "task1163-c0f9f10adde047bd9ab28a6c54e32d22", "input": "and could be used as an effective supplementary indicator.", "output": [ "finding" ] }, { "id": "task1163-cc5aabb8306f415cb7912d725a47acd8", "input": "Aim of the study is to determine neuroprotective effects of the musk of muskrat on focal cerebral ischemia.", "output": [ "purpose" ] }, { "id": "task1163-db8ef7b9d63d42e29da5a68d713690e1", "input": "and others that are widely viewed as imminent.", "output": [ "method" ] }, { "id": "task1163-a3f58c380110438aa78381d37073be24", "input": "This chapter reports the applicability of ionic liquids in the formation of different types of multicomponent reactions.", "output": [ "purpose" ] }, { "id": "task1163-d29f01fed23241948a97d9cb9cb65f51", "input": "There were multiple instances of published articles during the height of the outbreak containing potentially misleading scientific language that spurred media overreaction and potentially jeopardized preparedness and policy decisions at critical points.", "output": [ "background" ] }, { "id": "task1163-b1aaa7c0d80b48548bf66b579a323b36", "input": "Two naïve sentinel calves were commingled with the experimentally exposed group three weeks after exposure.", "output": [ "method" ] }, { "id": "task1163-7fa2ab1a7b7b44429520fa4f2791610e", "input": "the protein was overexpressed in E. coli and purified by Ni-NTA chromatography.", "output": [ "method" ] }, { "id": "task1163-d0216b751025411dac83fe7c72b5e05b", "input": "In this Pearl , we focus on how direct and indirect interactions between viruses and bacteria impact viral biology and touch on recent findings that illustrate how bacterial biology can also be impacted by interactions with eukaryotic viruses ( Fig 1 ).", "output": [ "finding" ] }, { "id": "task1163-0f55960b4d334b40bab7280d66d0f61c", "input": "In subgroup analysis , we compared two groups ( with or without the use of the prediction rule ) after implementation period , using propensity score matching.", "output": [ "method" ] }, { "id": "task1163-ac664177c4dc4753916d818a9eae5fe1", "input": "international collaboration among scientists is essential to address these risks and prevent the next pandemic.", "output": [ "purpose" ] }, { "id": "task1163-c31938db974e409292d67ad3cbcc7017", "input": "Avian paramyxoviruses ( APMVs ) are frequently isolated from domestic and wild birds throughout the world and are separated into nine serotypes ( APMV-1 to -9 ).", "output": [ "background" ] }, { "id": "task1163-352566d5e7494b018992ed4cc92f2466", "input": "These results demonstrated that peptide Kn2-7 could inhibit HIV-1 by direct interaction with viral particle and may become a promising candidate compound for further development of microbicide against HIV-1.", "output": [ "finding" ] }, { "id": "task1163-bd916450ceac452e943cc4fe0f02824d", "input": "The purpose of this study is to examine how cost-benefıt analyses were used during the rapid diffusion of 2-1-1 across states.", "output": [ "purpose" ] }, { "id": "task1163-2a2390153ae143b9ab49ee28060490fb", "input": "In this study , we established a high-throughput screening ( HTS ) system based on CHIKV 26S mediated insect cell fusion inhibition assay.", "output": [ "purpose" ] }, { "id": "task1163-7a8c18f638c94217bac6d1f953a6cc79", "input": "the discovery of which goes back 80 years to the time when penicillin was discovered by Alexander Fleming.", "output": [ "purpose" ] }, { "id": "task1163-fffc23e27a434b709683a5ec8c8dd040", "input": "Such a conclusion could be further verified by the results that the proteolytic activities of these mutants also decrease to varying degrees.", "output": [ "finding" ] }, { "id": "task1163-ee02f29fba3946979a41cce560c6118d", "input": "The purpose of this review is to summarize the achievements of using self-replicating RNA viruses for RNA therapy based on preclinical animal studies and clinical trials in humans.", "output": [ "purpose" ] }, { "id": "task1163-b31c4bae3a2649d488127c1152118747", "input": "mortality and quality of life.", "output": [ "background" ] }, { "id": "task1163-976330cb6e494372b8b4a832f617ca9f", "input": "indicating that this lncRNA plays a major role in attenuating inflammasome activation.", "output": [ "finding" ] }, { "id": "task1163-e6336363a3624e57b43d7bf39348c8b9", "input": "Physical examination revealed only mild respiratory distress.", "output": [ "finding" ] }, { "id": "task1163-7f7e9dd965a840b2a5778f7fee306157", "input": "Random contact is not considered in this model.", "output": [ "method" ] }, { "id": "task1163-767bb8878a634ffa9d3f1e7cda8e4f12", "input": "Our study aimed to understand the tropism of MERS-like-CoVs in bats by mapping the distribution of DPP4 expression in tissues from four bat species.", "output": [ "purpose" ] }, { "id": "task1163-ac8838b863d94ba0a418d6e0512739a2", "input": "we examined 2-5AMD in human cells.", "output": [ "method" ] }, { "id": "task1163-288683504b464e70916a0f0c6daff46e", "input": "accurate diagnosis and epidemiological control of the disease are now possible.", "output": [ "background" ] }, { "id": "task1163-39cb7839aa354b5b93632f534ac4bb18", "input": "It was found that the effects of EGFP-nsp15s on MHV replication were both virus species-and nsp15 domain-dependent.", "output": [ "finding" ] }, { "id": "task1163-ef7ff9aee23a4c57868b48ff38553775", "input": "- barrel fold ; HK97-like fold ; Double - barrel trimer Often the size of the virus is proportional to the size of the genome.", "output": [ "background" ] }, { "id": "task1163-8c96eeaf31fe4979aa0221075acfbbe3", "input": "responses to the severe acute respiratory syndrome ( SARS ) outbreak in 2003 and the Middle East respiratory syndrome ( MERS ) outbreak in 2015 had completely different outcomes.", "output": [ "background" ] }, { "id": "task1163-1d671ed41cad4d99820aac1b827c8a16", "input": "parameterised to the 2019-nCoV outbreak.", "output": [ "method" ] }, { "id": "task1163-3f5bda61dd6443ab83044ecedb01baca", "input": "However , many other factors contribute to wheezing such that there is no simple relationship between allergen exposure and asthma.", "output": [ "finding" ] }, { "id": "task1163-f58737c378264f1796e61620b1ae7e35", "input": "Here we describe the average family dog in the Western hemisphere owned by an average family without sufficient knowledge about potential hazards their pet might transmit to family members.", "output": [ "background" ] }, { "id": "task1163-dde6d0032e534914b756db8565a419b0", "input": "is still viewed from a nationalist perspective as solely benefiting a nation 's economy and its economic and political influence.", "output": [ "background" ] }, { "id": "task1163-65055af151e749f28133608410a610e3", "input": "Thrombocytopenia became accentuated on the 72 dai.", "output": [ "finding" ] }, { "id": "task1163-26ba5c2d2349446386143ea3e2d81d7f", "input": "We present an intuitive and clear visual design for tracking the citation history of a particular scientific fact over time.", "output": [ "purpose" ] }, { "id": "task1163-4cac5cb2fc3c49c1b8d56decb85dc818", "input": "A similarity search using SARS M pro protease subpockets as queries retrieved ligands and ligand fragments accommodated in a physicochemical environment similar to that of the query.", "output": [ "method" ] }, { "id": "task1163-e33aa9c16c3c4178a072658eda223b74", "input": "As such , data are urgently needed about risk factors associated with clinical outcomes.", "output": [ "purpose" ] }, { "id": "task1163-347429268d5e4db69ff84d3e1e142184", "input": "In this paper , an effective cloud computing architecture is proposed which predicts H1N1 infected patients and provides preventions to control infection rate.", "output": [ "purpose" ] }, { "id": "task1163-d6ceba17fa92447dbd1378d31ec940cd", "input": "This Review discusses the diverse strategies that viruses use to subvert host protein synthesis functions and regulate mRNA translation in infected cells.", "output": [ "purpose" ] }, { "id": "task1163-dc05c2363c6746b285bf0a0162799064", "input": "Administration of these vaccines to animal model systems has shown promise for the generation of efficacious and safe vaccines.", "output": [ "background" ] }, { "id": "task1163-f859fdb9b26a4bab9d74c21f87228b2c", "input": "particularly in instances where data required to manage response is only available after disasters unfold.", "output": [ "finding" ] }, { "id": "task1163-d6fb746b0b564aea817583653f47cfbe", "input": "but T lymphocytes , which may account for up to 80 % of the mucosal lymphoid cell population.", "output": [ "background" ] }, { "id": "task1163-c09fd92f7dcf41cd89a4bad3f39ec84a", "input": "but there is still significant growth potential.", "output": [ "background" ] }, { "id": "task1163-f7e5c244414048d3b56f204a6aa2321d", "input": "Synthesized compounds were evaluated for their antimicrobial and cytotoxic activities.", "output": [ "method" ] }, { "id": "task1163-05fb3546fed140648086227791947633", "input": "Participants were followed over 4 weeks ( 7th May 2015 to 4th June 2015 ) for development of clinical respiratory illness ( CRI ).", "output": [ "method" ] }, { "id": "task1163-1c885f8091644878ba151aa561aab432", "input": "5 % carbon dioxide , and 1 ppm ozone for 96 hr.", "output": [ "method" ] }, { "id": "task1163-4dd017c6de4a4c4e9732c959d0337679", "input": "myocarditis , and thrombotic meningoencephalitis.", "output": [ "background" ] }, { "id": "task1163-717ac4a2e1904476936b675bc1385798", "input": "In this review , we discuss the interaction between the innate and adaptive immune systems in the skin as a model for immune function at epithelial-cell interfaces with the environment.", "output": [ "purpose" ] }, { "id": "task1163-c920e73ff0f54e30865e3d1f3fb92471", "input": "we carried out competitive fitness experiments.", "output": [ "finding" ] }, { "id": "task1163-08e3a102b63840b5a065cbb3c7380b59", "input": "In this study , a solar-driven exhaust air thermoelectric heat pump recovery ( SDEATHP ) system is tested and evaluated for its ability to recover thermal energy from exhaust air to cool or heat fresh air.", "output": [ "purpose" ] }, { "id": "task1163-c578ec202b9842ca82f359a938d371d0", "input": "The charge transfer ( CT ) mechanism across the hybrid structure was simply clarified on the basis of the redox potential location of the species.", "output": [ "finding" ] }, { "id": "task1163-6923974226ab481aaec86ca28241c0cb", "input": "Diagnosis was made by specific laboratory tests according to the national technical guidelines.", "output": [ "method" ] }, { "id": "task1163-3c0660c91eca40219c4f32632c34e14f", "input": "and a disease-free status will become more uncertain as time from testing elapses.", "output": [ "background" ] }, { "id": "task1163-db63fa3e68094a00a3042f86661ea962", "input": "In the current study we examined the molecular mechanisms underlying these observations in vitro and in vivo.", "output": [ "purpose" ] }, { "id": "task1163-9b03d7709ece462f938d713129eba4b5", "input": "morbidity , and cost , and they have been identified as such for > 40 years.", "output": [ "background" ] }, { "id": "task1163-71dd7f090992468591a44733464566cf", "input": "The interaction with lipids of a synthetic peptide corresponding to the transmembrane domain of influenza hemagglutinin was investigated by means of electron spin resonance.", "output": [ "method" ] }, { "id": "task1163-60354dd36457403192ca9f6219759c11", "input": "In this study , high-throughput sequencing was used to explore differences in the intestinal microbiota between uninfected piglets and piglets infected with porcine epidemic diarrhea virus ( PEDV ).", "output": [ "purpose" ] }, { "id": "task1163-67c1eb9497484136b62404288284782b", "input": "We conducted a prospective case-ascertained study on laboratory-confirmed COVID-19 cases and their contacts.", "output": [ "purpose" ] }, { "id": "task1163-77a4ab2caaed47d58ed055808384922d", "input": "Our 45 approach compares multiple machine learning algorithms in a unified environment to 46 find the model with the best predictive performance and uses game theory to better 47 interpret results.", "output": [ "method" ] }, { "id": "task1163-9b8e4557b8bc48168d9bb4f0868d0d0e", "input": "attitudes towards the pandemic and willingness to accept the pandemic ( H1N1 ) 2009 influenza vaccine.", "output": [ "purpose" ] }, { "id": "task1163-a380b79e7c6141518993ed4522762368", "input": "purified and subjected to sequencing in both directions.", "output": [ "method" ] }, { "id": "task1163-3c6c7f1a2e0a4217a62d240734edc5f7", "input": "Primary sequences derived from these products were used to design additional primers resulting in the amplification and sequencing of the entire ORF1 of PEDV.", "output": [ "method" ] }, { "id": "task1163-6f17857749cb4fcdb47b10faf1261a3f", "input": "At least 1G raw data was obtained for each sample.", "output": [ "finding" ] }, { "id": "task1163-13cb90943b864634b854430f5e457446", "input": "resource implications , and the feasibility and acceptability of the recommendations.", "output": [ "purpose" ] }, { "id": "task1163-f056093161744aafb587373dd48f7de1", "input": "multi-organ dysfunction , and death.", "output": [ "purpose" ] }, { "id": "task1163-b9ccde963fb74da0a035a18fb06e792f", "input": "A recombinant vaccinia virus producing the bacteriophage T7 RNA polymerase was used to express foreign genes in eukaryotic cells.", "output": [ "background" ] }, { "id": "task1163-8f5bbbdb71774f0ea8cbf7a068e4fdae", "input": "Nea politan mastiff , Pug and Great Dane.", "output": [ "finding" ] }, { "id": "task1163-df191a44acb5415e806ff325c6563a0c", "input": "while compensation of the fidelity phenotype did not.", "output": [ "finding" ] }, { "id": "task1163-edbe7146618e4787a205faccba447c7d", "input": "Conclusions : MERS-Cov infection is more common in male , advanced age and diabetes.", "output": [ "finding" ] }, { "id": "task1163-98264f2bf7a143c5a87f7a23d922b6d9", "input": "and he was found to have a new left-sided infiltrate on CXR , consistent with a pneumonia.", "output": [ "background" ] }, { "id": "task1163-48799467ba904a3998d647220493bbad", "input": "All the proteins were expressed and purified using a GST-fusion expression system in Escherichia coli.", "output": [ "method" ] }, { "id": "task1163-85848a5974a246abac849045d2518001", "input": "Until the 18 th century many European cities were frequently affected by other great plague epidemics.", "output": [ "background" ] }, { "id": "task1163-b08983a7f271492da699eec1d962ae92", "input": "and canine parain £ uenza virus.", "output": [ "background" ] }, { "id": "task1163-8464934af2674192b6427010c1dc4603", "input": "recent studies suggest that the conjunctiva may represent a possible transmission route ( 5 , 6 ).", "output": [ "background" ] }, { "id": "task1163-f6e5e010af1b4a3e8126370f341737de", "input": "The isolate from the infant ( S1 , isolated from a tracheal sample ) and 7 isolates from the 6 health care workers ( S2 , isolated from skin lesions of 1 physician ; S4 and S5 , from nasal and anal samples from another physician ; and S3 , S6 , S7 , and S8 , from nasal samples from 4 nurses ) were genotyped and analyzed for the presence of the PVL gene.", "output": [ "finding" ] }, { "id": "task1163-ec4cc9135c7e44b091c8a4824a0839b6", "input": "However , practical deployment of the technology is hindered by the bioinformatics challenge of analyzing results accurately and in a clinically relevant timeframe.", "output": [ "background" ] }, { "id": "task1163-cd6bb7e5fd6e4531b202f193d17f305f", "input": "66.7 % of ovine liver samples and 71.4 % of ovine spleen samples.", "output": [ "finding" ] }, { "id": "task1163-fbf1d180cf99425d8f314c45421d8625", "input": "it is of paramount importance that the best use should be made of the resources available.", "output": [ "finding" ] }, { "id": "task1163-e7f02fbd72144766b12d6d8f1a8d5aba", "input": "We show that aged mice ( 16-19 months old ) are more resistant to influenza A virus ( IAV ) infection than the young mice.", "output": [ "finding" ] }, { "id": "task1163-50b86528b8674df2812052aac689938b", "input": "The degree of SCUB divergence varies greatly among different species and genes ( 4-7 ).", "output": [ "background" ] }, { "id": "task1163-5db171f712584abb87426090a6965264", "input": "Here we use a murine model for evaluation of the induction of humoral and cellular immune responses by inactivated and PHE-CoV DNA vaccines in order to define the immune correlates for protection against PHE-CoV.", "output": [ "purpose" ] }, { "id": "task1163-6fb1741923514244b25cf191258df65a", "input": "The speed of the spread of the SARS epidemic was unprecedented due to the highly efficient intercontinental transportation.", "output": [ "background" ] }, { "id": "task1163-16f75fd4eb144623a89a04b3c40ea0de", "input": "In this study , we determined the crystal structures of two neutralizing human antibodies bound to prefusion RSV F.", "output": [ "finding" ] }, { "id": "task1163-4f110d80544b4bd19286c702bddc64ca", "input": "The results show that we can get satisfactory information from financial markets by this method.", "output": [ "finding" ] }, { "id": "task1163-340025ff7ec54808bd1206b612eede4c", "input": "and both 3xTg and 3xTgQ - / - were backcrossed to the BUB mouse strain which has higher in vitro hemolytic complement activity.", "output": [ "method" ] }, { "id": "task1163-8e69c23cec394d2fb4adb3bdc4047642", "input": "We recently observed six cases of generalized dermatitis associated with Malassezia overgrowth in cats presented to the Veterinary College of Alfort , France.", "output": [ "background" ] }, { "id": "task1163-4afe29796858451284d2ccb19f71df76", "input": "IgG1 Abs from colostrum origin are critical for prevention of BCoV infection.", "output": [ "finding" ] }, { "id": "task1163-474978453b914d98b0e181eb23357ae4", "input": "In this report , the swine IFITM3 ( sIFITM3 ) gene was cloned.", "output": [ "background" ] }, { "id": "task1163-e5cb2bb9811347ba8f3682b4896a9ef7", "input": "partially overlapping , transcriptional program initiated by the interaction with specific receptors.", "output": [ "background" ] }, { "id": "task1163-9ef013a7124e4a6b8d370aade516048f", "input": "underwent phagosomal escape but were cleared from the host cytosol.", "output": [ "finding" ] }, { "id": "task1163-2e840793718c4fe5aa510d6d3a742475", "input": "However , the pathogens have never been detected in the local human population prior to or at the same time as an outbreak.", "output": [ "background" ] }, { "id": "task1163-e306b895fc6a49179577e42e2a4abb61", "input": "This review discusses some of the key aspects of inflammatory monocyte trafficking to the brain and addresses the role of these cells in viral encephalitis.", "output": [ "purpose" ] }, { "id": "task1163-dd17a281164448a7bee7a694a39f8452", "input": "associates with mitochondrial proteins and alters mitochondria morphology to promote infection.", "output": [ "finding" ] }, { "id": "task1163-622528b987354b6982d480b06c3ce499", "input": "It was notable that blood flow from the trachea was observed during intubation.", "output": [ "finding" ] }, { "id": "task1163-0414cb61f601432bb353adc1c13b8f0e", "input": "Clustering results based on relative synonymous codon usage ( RSCU ) values could provide useful reference for phylogenetic relationship analysis ( 18,19,22 ).", "output": [ "background" ] }, { "id": "task1163-15dbc7d325cf4e95b50ab10d609d4f65", "input": "In this review we examine protein-G-quadruplex recognition in physiologically significant conditions and discuss how to possibly exploit the interactions ' selectivity for targeted therapeutic intervention.", "output": [ "finding" ] }, { "id": "task1163-9e7675462ea648c386d191f4bd4a2636", "input": "Moreover , we designed the double-quencher probes ( YCH assay ) according to the oligonucleotide sequence established by NIID.", "output": [ "method" ] }, { "id": "task1163-06138229245a4b4b8728e5326e374df4", "input": "Bioinformatics analysis of this non-structural protein has now revealed a nidoviral signature domain ( genetic marker ) that is N-terminally adjacent to the RdRp and has no apparent homologs elsewhere.", "output": [ "background" ] }, { "id": "task1163-c4283b72a9824172a4f3b8facf4aa07d", "input": "referred to as antigenic site Ø.", "output": [ "background" ] }, { "id": "task1163-460552d3724a429a904cc5896134df5e", "input": "Median calf age at enrollment was 11 d and ranged from 1 to 26 d of age.", "output": [ "method" ] }, { "id": "task1163-8762effe5b1d4b1ebb0f27c726eedbe1", "input": "Therefore , the objective of this study was to examine changes in gene expression and investigate molecular pathways involved in the immune-competence development of neonatal Holstein dairy calves and naturally suckled beef calves using next generation RNA-sequencing during the first week of life.", "output": [ "purpose" ] }, { "id": "task1163-b1a5f3f342cd4aa2986faecf716d57d7", "input": "IL-6 , IL-10 , and TNF-α.", "output": [ "finding" ] }, { "id": "task1163-2943488417204a1fa3e6a79c2e977a92", "input": "Researchers collected questionnaire data from international leisure and business tourists to Thailand on importance of safety and security measures.", "output": [ "method" ] }, { "id": "task1163-f2f952c365514eb7a35e21cac6f523e1", "input": "the crossover points usually consist of two to six identical nucleotides.", "output": [ "background" ] }, { "id": "task1163-74c6450caa1647d9b7d2baaa9c2bcc49", "input": "In this study , we investigated recombinant Modified Vaccinia virus Ankara ( MVA ) for delivery of NiV-G antigens ( 46 ).", "output": [ "purpose" ] }, { "id": "task1163-79fa0afca14c4160ac23e8095d9abb6f", "input": "we construct a new community network model in which the communities show significant differences in average degree.", "output": [ "purpose" ] }, { "id": "task1163-b1bc9977b467423eb72548eba7be70d8", "input": "Penta-O-galloyl-glucopyranose ( PGG ) was identified as the most potent gallotannin.", "output": [ "background" ] }, { "id": "task1163-005c8f82a95d40d4ac85944e1aba780b", "input": "and could thus slow the pace of resistance development.", "output": [ "purpose" ] }, { "id": "task1163-50315ead57194538b5d392dd81eb09c0", "input": "Plants are low-cost bioreactors for the production of various biopharmaceuticals including oral vaccines.", "output": [ "background" ] }, { "id": "task1163-4a77452d600c42e295773a450a6fb036", "input": "Poisson and negative binomial regression models were used to study the trends of injury incidence rate at different body regions.", "output": [ "method" ] }, { "id": "task1163-4d30649ac5c24c92a69ea91b2c5db5c0", "input": "hip joint MRI examinations , pulmonary function tests and hip joint function questionnaires.", "output": [ "method" ] }, { "id": "task1163-4b9f8179543f409a89925fb4ef08ce73", "input": "have been qualitatively and quantitatively insufficient.", "output": [ "background" ] }, { "id": "task1163-fd08ca33d24740438cdf4d5951b5688b", "input": "The majority of SHAPU patients had multiple anelloviruses in their VF.", "output": [ "finding" ] }, { "id": "task1163-bc2dce5a7da245fba0ae2bc40be8a4d1", "input": "with a half-life of > 22 days at 37 °C.", "output": [ "finding" ] }, { "id": "task1163-3ec9fbebc443403aa39816d2949349d1", "input": "A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls.", "output": [ "method" ] }, { "id": "task1163-e391d2203a8f47079a95eaf6bed13c1b", "input": "Methods : Archived records from 5 institutions were retrospectively reviewed to identify cases with confirmed neurologic FIP that had undergone antemortem MRI of the CNS.", "output": [ "method" ] }, { "id": "task1163-99117600b9e5445b86ca5628982a3cca", "input": "hemoglobin of 14.1 g/dL , and platelet count of 195,000 / μL.", "output": [ "finding" ] }, { "id": "task1163-0023a38787ce43f2b7a4ee6f5f527f2a", "input": "Objectives : The present study aimed to examine the trends and characteristics of fall-related attendance in accident and emergency department ( AED ) by injury type and the trend in associated average length of stay ( LOS ) among children and adolescents in Hong Kong.", "output": [ "purpose" ] }, { "id": "task1163-53fc5e6c385f4acbafece63cfc089ac8", "input": "We compare our results across several variants of Susceptible-Infectious-Recovered ( SIR ) compartmental models to quantify the impact of modeling assumptions on our estimates.", "output": [ "method" ] }, { "id": "task1163-1826d5bcb7ac4b07963542277affc1f7", "input": "The V , D and J genes of the IgH DNA sequences were identified using the IMGT database as a reference ( Brochet et al. , 2008 ; Ye et al. , 2013 ).", "output": [ "method" ] }, { "id": "task1163-03bba73199e44d6d8b767020e0a3a87b", "input": "Predictive studies have begun to identify pathogen traits associated with emergence.", "output": [ "background" ] }, { "id": "task1163-45c1277fb70644049e13c1da02ff1b7e", "input": "and respiratory disorders in cattle of all ages.", "output": [ "background" ] }, { "id": "task1163-7a42f89485c8461fadd877f674dc5e2f", "input": "Viral bronchiolitis is a common clinical syndrome aff ecting infants and young children.", "output": [ "background" ] }, { "id": "task1163-fbe3c205b45d48c4bf850deb69f5c5f9", "input": "This allowed the characterization of the protease recognition pockets and the identification of molecular building blocks that can be incorporated into novel antiviral compounds.", "output": [ "method" ] }, { "id": "task1163-9e288409c6e34aeba5b2d0c8f6a0a63c", "input": "A multiplex real-time PCR assay using two reactions was developed for the detection and differentiation of these five pathogens.", "output": [ "method" ] }, { "id": "task1163-85ca802310cd4283859a6520949e9753", "input": "62 Establishing a high-throughput activity assay 63 Recombinant COVID-19 virus M pro with native N and C termini was expressed in 64 Escherichia coli and subsequently purified ( Extended Data Fig. 1a , b ).", "output": [ "background" ] }, { "id": "task1163-369933d5694b4a90a0c8b9871f906823", "input": "and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.", "output": [ "finding" ] }, { "id": "task1163-6a0620a9595543cdbfb12732ee0d267c", "input": "with animal abortion waves that had gone unnoticed.", "output": [ "background" ] }, { "id": "task1163-28a18a97638e43cfa85a30a5e09a74d2", "input": "focusing on the potential anti-viral or pro-survival mechanism of autophagy.", "output": [ "purpose" ] }, { "id": "task1163-0d052f65f31a44bc9a0531015e45cf71", "input": "homemade ( to be disclosed ) and placebo ( water ).", "output": [ "method" ] }, { "id": "task1163-047f3747e4da435581e49e6092aa7207", "input": "We estimated that the mean R 0 ranges from 2.24 ( 95 % CI : 1.96-2.55 ) to 3.58 ( 95 % CI : 2.89-4.39 ) associated with 8-fold to 2-fold increase in the reporting rate.", "output": [ "finding" ] }, { "id": "task1163-3e5f0455a72f48b1a4ee45040d1cd5fa", "input": "Here , we show that p53 represses expression of the rRNA methyl-transferase fibrillarin ( FBL ) by binding directly to FBL.", "output": [ "purpose" ] }, { "id": "task1163-f10c449c0bd0424a912b6818799f51f1", "input": "In particular , the central role of interferon-g as a primary mediator of CNS pathology during EAE has been challenged by the emergence of Th17 cells producing interleukin-17.", "output": [ "background" ] }, { "id": "task1163-7de73ad6456a4d06b758df14b7c2b073", "input": "Each of the 10 calves was then randomly allocated to one of two groups.", "output": [ "method" ] }, { "id": "task1163-99ec4ebf4b3c44e9aab71ea04a1c1fd3", "input": "diagnostic imaging , and cytologic and microbiologic analysis of bronchoalveolar lavage or transtracheal wash fluid.", "output": [ "method" ] }, { "id": "task1163-16bf83fbf34f40d5bbbaf6ecc7adce79", "input": "or by rather sophisticated mathematical methods.", "output": [ "background" ] }, { "id": "task1163-a9f8b069b3154c40a98a47a4162e6a5e", "input": "such as a facial mask and gloves.", "output": [ "finding" ] }, { "id": "task1163-eeda68a92d5b4b2b80c161fb0c4e7013", "input": "Based on phylogenetic evidence , transmission from humans is likely.", "output": [ "background" ] }, { "id": "task1163-85879ff8ec98478789831a161fe2835f", "input": "but may also depend on sequences removed from the cleavage site.", "output": [ "finding" ] }, { "id": "task1163-3e4d5e7c637d48b9b4f3ebdc425271a1", "input": "an interferon ( IFN ) stimulated gene ( ISG ).", "output": [ "background" ] }, { "id": "task1163-9283a4f627624b0d806602f61e32cc7a", "input": "In this work , a review was done on the most recent publications concerning their antioxidant and anti-inflammatory activities.", "output": [ "purpose" ] }, { "id": "task1163-15af89a1d84744fa8655018afcea425c", "input": "a one-touch computational pipeline for virus identification and discovery from metagenomic NGS data.", "output": [ "purpose" ] }, { "id": "task1163-583ab235a69d4810b3777c71e4457565", "input": "Calves were monitored daily for signs of disease.", "output": [ "method" ] }, { "id": "task1163-b47c4ee8658d48b4adf70428a08e2640", "input": "provides recommendations for current and future use of nonanimal methods and strategies for veterinary vaccine potency testing.", "output": [ "background" ] }, { "id": "task1163-d78deaa9c8664971a1c7661021080a28", "input": "The three-dimensional structure of DV fusion peptide bound to DPC micelles was solved by solution homonuclear NMR with an r.m.s.d. of 0.98 Å.", "output": [ "method" ] }, { "id": "task1163-c414aa622d634239883c16d1a87cb0c0", "input": "moral/ethical reasonings and global public goods frames identified in the literature.", "output": [ "purpose" ] }, { "id": "task1163-26381f00a9b848a4b470c803bb0c4640", "input": "particularly influenza , more attention is being focused on the effectiveness of infection control procedures to prevent hospital-acquired infections by this route.", "output": [ "background" ] }, { "id": "task1163-d0204557f6d2490da6cf68b7df76cc07", "input": "In particular , it articulates the changing competitive dynamics between LCCs and full-service carriers ( FSCs ).", "output": [ "purpose" ] }, { "id": "task1163-063dd421ecc342feb19317968717f23c", "input": "with varying relative importance in different species ( 15 ) ( 16 ) ( 17 ).", "output": [ "background" ] }, { "id": "task1163-2213b29ede954397a43167aabf752406", "input": "These antibodies have not defined an etiology.", "output": [ "background" ] }, { "id": "task1163-fc5ddd7305944ceab374a0611ebfccc6", "input": "Multiple virus detections were found in 81.2 % and 78.9 % of CAI and HAI dogs , respectively.", "output": [ "finding" ] }, { "id": "task1163-b31810f423c847ea91ced51d3d06bb99", "input": "Clinical signs were monitored daily and oropharyngeal swabs were taken at regular intervals for vaccine virus detection.", "output": [ "method" ] }, { "id": "task1163-e66bc8cb364d41778fa0d1e9ce86a2b7", "input": "Sequence comparison and modeling analysis have revealed a putative receptor-binding domain ( RBD ) on the viral spike , which mediates this interaction.", "output": [ "background" ] }, { "id": "task1163-9d5a206482ab4945b72ca7debb50d2e0", "input": "emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community.", "output": [ "background" ] }, { "id": "task1163-ee5b066999234d5c911d2d267ab455a3", "input": "This review provides a description of current and potential biological threats that are likely to require nonhuman primates for the development of vaccines and therapeutics.", "output": [ "purpose" ] }, { "id": "task1163-f849386f75df408b9221b4c6ab5056fb", "input": "Moreover , we would like to perform a detailed stability and bifurcation analysis of the 47 proposed model.", "output": [ "purpose" ] }, { "id": "task1163-1d63412c2abd4603931d16993cb15964", "input": "and mass spectrometry are briefly discussed.", "output": [ "purpose" ] }, { "id": "task1163-8011bf452fb94899b3c97bbfdb40f37a", "input": "self-amplification of transcripts and induction of apoptosis were analyzed in transfected mammalian cells.", "output": [ "method" ] }, { "id": "task1163-9873605c86c046518507f5398c54876b", "input": "This work represents a first approach to characterise the otter faecal microflora in samples collected in river stretches of the Sado river basin ( Portugal ) during winter 2006.", "output": [ "purpose" ] }, { "id": "task1163-5228e86c15c044eda5eacfc1a1418e50", "input": "Here we report the cloning and characterization of the cDNA and gene encoding porcine DC-SIGN ( pDC-SIGN ).", "output": [ "purpose" ] }, { "id": "task1163-1b56064fe63545b19f8bd112131e72ab", "input": "The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility.", "output": [ "finding" ] }, { "id": "task1163-5c8fc320980143419ee792068056bc12", "input": "The sudden emergence of severe acute respiratory syndrome ( SARS ) has boosted research on innate immune responses to coronaviruses.", "output": [ "background" ] }, { "id": "task1163-1369382b93674e36b44587754390ed6c", "input": "The interaction between SARS coronavirus 3C-like ( 3CL ) proteinase and an octapeptide interface inhibitor was studied by affinity capillary electrophoresis ( ACE ).", "output": [ "background" ] }, { "id": "task1163-783a4b1c00654844bcc03fd8785f0289", "input": "efficient frameshifting is critically dependent upon virus infection.", "output": [ "finding" ] }, { "id": "task1163-5f198f059cfb45fa831d2a3a1e07db30", "input": "by utilizing one-dimensional liquid chromatography mass spectrometry.", "output": [ "method" ] }, { "id": "task1163-274d47cd2fdc4e199959b75c6422f273", "input": "Subsequently , the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines : MCF7 and MDA-MB468.", "output": [ "purpose" ] }, { "id": "task1163-78daa5448768448792333e464e0a2808", "input": "during 2016 we surveyed HLIUs.", "output": [ "method" ] }, { "id": "task1163-645d7e9ea79c4b50a24a8dbf69c926cb", "input": "Given its cost-and time-effectiveness , this quantitative LAMP assay is suitable for screening lake trout populations and for the initial diagnosis of clinical cases.", "output": [ "finding" ] }, { "id": "task1163-8bf80b3acfa24040aebe068e9198b9ef", "input": "This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines.", "output": [ "purpose" ] }, { "id": "task1163-774535a1562e46648bdebdef9309509f", "input": "The polymerases of RNA viruses generally lack proofreading activity and exhibit extremely high mutation rates.", "output": [ "background" ] }, { "id": "task1163-b338e33b5f314cd09b29002216adba6b", "input": "This work proposes a framework to test and evaluate PPE with a focus on gown design.", "output": [ "purpose" ] }, { "id": "task1163-bb9e383d89c940a5aca8988648f6812a", "input": "post exposure , or treatment of Ebola virus disease ( EVD ).", "output": [ "purpose" ] }, { "id": "task1163-10cb69ed4d6f41899c08bcd756132b75", "input": "71 , and 80 , as well as a double proline substitution at residues 55 and 71.", "output": [ "method" ] }, { "id": "task1163-5f6e7600c64e46bca7dfa5c6cc5c22d4", "input": "and leukotrienes are likely mediators.", "output": [ "background" ] }, { "id": "task1163-dc7eda9c3358436a9c75a314e71cd1eb", "input": "Pneumonia was defined as two or more respiratory symptoms and signs and an opacity on a chest radiograph as interpreted by the attending physician.", "output": [ "method" ] }, { "id": "task1163-4f0278bc32214c7291bc9dd8f99e98ac", "input": "patient enablement and patient satisfaction.", "output": [ "method" ] }, { "id": "task1163-5db0febdc1f94b5d979beb2c27f4cfea", "input": "The striking finding is of reduction in natural killer ( NK ) cells but preservation of activated effector CD8 T lymphocytes ; with viraemia in the patient who had no NK cells.", "output": [ "finding" ] }, { "id": "task1163-c5b81d18019a49ddb6b9e9c5c3446b11", "input": "Results showed that the diagnostic sensitivity and specificity of the assay were 90.9 % ( 10/11 ) and 82.9 % ( 39/47 ) , respectively.", "output": [ "finding" ] }, { "id": "task1163-82065f00501f448db92a3cfb2b77ecc4", "input": "Collectively , these data can delineate pathogenic mechanisms and thereby help maximize beneficial therapeutics.", "output": [ "method" ] }, { "id": "task1163-b5fe20692be249fc82cfde0e7936a313", "input": "Different alcohols and commercially available hand antiseptics had a virucidal effect against HBV.", "output": [ "finding" ] }, { "id": "task1163-5513363bebd543a6be0557fdbabd3739", "input": "Objective : To describe the clinicopathologic features and MRI findings in cases of confirmed neurologic FIP.", "output": [ "purpose" ] }, { "id": "task1163-4947d251adb44f8b8c6dd9338fcd7ff6", "input": "19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014.", "output": [ "purpose" ] }, { "id": "task1163-de10958709774fbc902d95411aefc37d", "input": "We interpret our results in support of the hypothesis that the spring-loaded conformational change is required for fusion.", "output": [ "finding" ] }, { "id": "task1163-63fc2d00260a463abc8946cf4455d72e", "input": "single mismatch detection and low current response.", "output": [ "background" ] }, { "id": "task1163-dd570fab9c7b4dc5b217e4ca3dbd326c", "input": "from viral pathogens with an area under the receiver operating characteristic ( ROC ) curve of 0.73 ( 95 % confidence interval ( CI ) , .69-.77 ).", "output": [ "finding" ] }, { "id": "task1163-b50bb11a5052428495047c4d27ec21ce", "input": "This chapter comprises the state-of-art advancements in the development of nano-antimicrobial biomaterials for biomedical applications.", "output": [ "purpose" ] }, { "id": "task1163-c2ba0e3e0ecd48e8b69205623332d555", "input": "they are capable of rapid spread throughout the host.", "output": [ "background" ] }, { "id": "task1163-4235817eba9741c380ce19d18113ffa9", "input": "and systemic adverse events were determined by a blood test.", "output": [ "method" ] }, { "id": "task1163-f7be53455dd94ba988790d0a5ca121f9", "input": "albeit to lower levels than that achieved in Huh7 cells.", "output": [ "method" ] }, { "id": "task1163-b3c34168b40c4cc9a17065fb1b6016f8", "input": "and 64 % ( 91/143 ) of healthy and diarrheic calves , respectively.", "output": [ "finding" ] }, { "id": "task1163-53b6e1b88f5146808a89466c13defded", "input": "In this work , we investigate how ZIKV modulates SG assembly.", "output": [ "purpose" ] }, { "id": "task1163-abf2718446064f0cb42a882ded2ce3c4", "input": "symptomatic without pneumonia , and viral pneumonia.", "output": [ "method" ] }, { "id": "task1163-b2bf5fc55dea4167929346b46a7960d7", "input": "open-label , randomized , phase III clinical trial.", "output": [ "method" ] }, { "id": "task1163-2e495cf021b141f99bbdcae91d940343", "input": "and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.", "output": [ "method" ] }, { "id": "task1163-0167ee0607694fb190df4a65c2e46c1b", "input": "for all outbreaks , was more extreme than would be expected by chance under the null hypothesis that proximity was not associated with transmission risk.", "output": [ "method" ] }, { "id": "task1163-c3eb4bf4349a41dcb83ede14306a8920", "input": "However , it must be applied repeatedly throughout the day due to rapid plasma membrane turnover and the subsequent loss of n-docosanol ( 9 ).", "output": [ "background" ] }, { "id": "task1163-1b749d200e5645b5b1711a4e90c53f34", "input": "inflammation occurs in the demyelinating lesions with progression of the lesions in some animals.", "output": [ "background" ] }, { "id": "task1163-d6fe5142a4fa479dba99ff965b342aad", "input": "i.e. , B4 , B12 , B15 , and B19.", "output": [ "purpose" ] }, { "id": "task1163-51ec2be627434711a32ff531d36ede14", "input": "This response requires pDC-intrinsic MyD88-dependent signaling by Toll-Like Receptors 7 and 9.", "output": [ "background" ] }, { "id": "task1163-9f4b64afe4364a5e86cf20fc87e87f78", "input": "None of the 30 influenza-positive travellers had tympanic temperature $ 37.8 uC at screening ( 95 % CI 0 % to 12 % ) ; three had no influenza symptoms.", "output": [ "finding" ] }, { "id": "task1163-347e06ad0a5f42b3b5852f01173c0531", "input": "both from their acute impairment of the vocal mechanism and their predisposing influence for the development of serious vocal sequelae.", "output": [ "background" ] }, { "id": "task1163-5f93264354944105a2cad39138bc1dea", "input": "comprising a 5 1 terminal cap structure and a 3 1 poly A tail.", "output": [ "background" ] }, { "id": "task1163-850378bcdc1e43ceafaa3a7c0352cf8e", "input": "such as a certain pH and temperature and a given concentration of cosolvent ( s ).", "output": [ "background" ] }, { "id": "task1163-9dd0a302c7c34657b28d059cd3cc4a1a", "input": "which is regulated through dynamic interplay among intracellular lectins , glycosidases , and glycosyltransferase.", "output": [ "purpose" ] }, { "id": "task1163-45238e678efb4d58a08e2633e08faa8c", "input": "the average number of secondary cases generated by a single primary case.", "output": [ "method" ] }, { "id": "task1163-1f1a00a2ce16495aabdbd5d62d4351b5", "input": "and there are many factors that can affect their occurrence.", "output": [ "background" ] }, { "id": "task1163-551d37fa08784957a11c61485d176ef2", "input": "Results from death and severe cases showed that LYM % in blood tests were inversely associated with the severity and prognosis of COVID-19.", "output": [ "finding" ] }, { "id": "task1163-6c2bc6fb1fec496cbf0f4bdb298d2692", "input": "we collected nine patients with COVID-19 infections who had undergone chest radiography and CT scans.", "output": [ "method" ] }, { "id": "task1163-e887fd256af643b08d48f9ff3fa303cf", "input": "Little is known about the relationship between EV-D68 virus and host cells.", "output": [ "background" ] }, { "id": "task1163-59db6019610441d4badc10002378f6cf", "input": "real-time monitoring of transmission is vital for containing the spread of COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-cd38873dd25c4aea9acd3d390b77fd0e", "input": "and ( ii ) the dysregulation of adaptive immunity.", "output": [ "background" ] }, { "id": "task1163-bf0bfe8a46154efebd1f308e2b75d844", "input": "leading to the shut-off of mRNA translation ( protein synthesis ) and the assembly of RNA granules.", "output": [ "background" ] }, { "id": "task1163-d2614273fd6948bea8295b6c6becbcb6", "input": "which cross-reacted with H7N9-M2e peptide.", "output": [ "method" ] }, { "id": "task1163-d60df28a370c48e181938ab14a6a9ada", "input": "Those with lower education levels less often used preventive measures ( aOR = 0.56 , 95 % CI = 0.46-0.69 ).", "output": [ "finding" ] }, { "id": "task1163-a5637ea5333040ffb611912a0fd36fb8", "input": "respectively , per 5 lL PCR reaction input.", "output": [ "method" ] }, { "id": "task1163-d45f47642f354dd1a43a8e23ca73212e", "input": "All local Arabian samples contained strains of the virus that belong to a novel recombinant clade ( NRC ) first detected in 2014 in Saudi Arabia.", "output": [ "finding" ] }, { "id": "task1163-293d8f79642946838958fed0e9eaad7f", "input": "nucleotide binding , dimerization , and ribonuclease functions highlights the evolutionary adaptability of the eukaryotic protein kinase fold.", "output": [ "finding" ] }, { "id": "task1163-bc44eff5521d4ce68b4284c13116122a", "input": "Using these assays , we conducted a one-step real-time RT-PCR with serial DNA positive control to assess the detection sensitivity.", "output": [ "method" ] }, { "id": "task1163-baca71e07ac14dc992c45c15689a4f3a", "input": "which means that a fast prediction method could allow for a high throughput of derived protein structures.", "output": [ "background" ] }, { "id": "task1163-ad96f9d89fc14619ba6e1c2a9e231864", "input": "Migration of the parasites can be accompanied by neuromotor disorders or paralysis in natural definitive hosts ( ducks ) and even in laboratory mammals.", "output": [ "background" ] }, { "id": "task1163-fd329df849c44da0b43d36f43bdee332", "input": "and IL-2 ( RE = 0.312 ).", "output": [ "finding" ] }, { "id": "task1163-bbef4dd26a3f44a08d930c9087f12b64", "input": "PVL-producing S. aureus is known to cause rapidly extensive and necrotizing pneumonia in children and young adults.", "output": [ "background" ] }, { "id": "task1163-5aba93e8d0d542d6be9ee93d45cc7d2f", "input": "or as star proteins if the protein is fused to both N-and C-termini.", "output": [ "background" ] }, { "id": "task1163-15073327242e42b9b024cefd61242e04", "input": "We describe isolation of infectious MERS-CoV from the upper respiratory tract of a mildly ill 27-year-old female in Saudi Arabia 15 days after illness onset.", "output": [ "purpose" ] }, { "id": "task1163-6f3fcdf84de947ea8baee1b8df313277", "input": "Ten single Asn-to-Ala substitutions at the predicted N-glycosylation sites of the M41-RBD were evaluated along with two control Val-to-Ala substitutions.", "output": [ "method" ] }, { "id": "task1163-029b441e7f9b4130aa332682cf3ebc1f", "input": "The wild-type S was palmitoylated as evidenced by the efficient incorporation of 3 H-palmitic acid in wild-type S molecules.", "output": [ "finding" ] }, { "id": "task1163-4442329e47d94ff2b650a716dbdaf2e1", "input": "especially females ( aOR = 1.47 , 95 % CI = 1.27-1.69 ).", "output": [ "finding" ] }, { "id": "task1163-edf42fd4b82342fd92676335eb9e9dab", "input": "Objectives : No data were available about in-flight transmission of SARS-CoV-2.", "output": [ "purpose" ] }, { "id": "task1163-62fc0d0d74094a70a4ea83b3fb25a0b0", "input": "and the recent , rapid spread of PHE-CoV in piglets from many countries emphasizes the urgent need for a PHE-CoV vaccine.", "output": [ "background" ] }, { "id": "task1163-f25ac20c768146c29a85a150fe7c9fd3", "input": "with a focus on the most recent advances in the development and application of polysaccharide-based antigen nanocarriers.", "output": [ "purpose" ] }, { "id": "task1163-a2cc5780e9c4453b9b05929e8323ad88", "input": "The viral ribonucleoprotein complex of human immunodeficiency virus-1 ( HIV-1 ) associates with the viral Envelope ( Env ) to form infectious virions.", "output": [ "background" ] }, { "id": "task1163-91ca5a360112437f9bdd03139f892c03", "input": "Data modeling was based on univariate and multivariate data analyses.", "output": [ "method" ] }, { "id": "task1163-7ac74cd1d39444c49902f4148c915e58", "input": "The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface.", "output": [ "purpose" ] }, { "id": "task1163-3ae1da7321804189afdf30718c2684ca", "input": "and siNS5B targeting NS5B gene describe previously.", "output": [ "method" ] }, { "id": "task1163-198233467fea440cb870b2be2e90badd", "input": "the viral polymerase , and multiple viral nucleoproteins.", "output": [ "finding" ] }, { "id": "task1163-3b355a373bab444dbe90113050ddc29e", "input": "to determine the extent of protection achieved against SARS-CoV challenge in this model.", "output": [ "purpose" ] }, { "id": "task1163-5c727e6f0c544ab7a43b0e295679920f", "input": "3D drafting skills , and computer simulations.", "output": [ "background" ] }, { "id": "task1163-04cc12c4cc1348f580c014170a10ce62", "input": "Analysis of Singapore 's outbreak improves our understanding of the social 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"clinical disease , and management accumulated within just 1 year.", "output": [ "background" ] }, { "id": "task1163-7ef306c11705414b84987980221ffb56", "input": "During three months , a total of 1,815 patients were tested ( including 236 patients infected H1N1sw virus ) and distribution in age groups and results of RIDT were analyzed.", "output": [ "method" ] }, { "id": "task1163-5e5fdd279d284cb4ac9874d008827318", "input": "The aim of this study was to determine how a homemade solution compared against a commercially available product and a placebo.", "output": [ "purpose" ] }, { "id": "task1163-261c7073233940a094642791d7029bf1", "input": "Being age ≥ 65 years ( OR = 4.0 ; 95 % CI : 1.6-9.9 ) and having an intensive care unit admission ( OR = 7.4 ; 95 % CI : 3.0-17.9 ) were independently associated with mortality.", "output": [ "finding" ] }, { "id": "task1163-16bb81b27bc045edbc4a4f73d998f803", "input": "Internal variations within each group can be simulated by assuming the possible 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"background" ] }, { "id": "task1163-2943b37077c24210b9e3893602c2d222", "input": "a small molecule inhibitor of the HCV NS5A protein that exhibits picomolar half-maximum effective concentrations ( EC 50 ) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture.", "output": [ "purpose" ] }, { "id": "task1163-53553fc17c1d4881945bd396f8715725", "input": "This paper demonstrated that persistent respiratory syncytial virus infection could contribute to the progression of COPD severity.", "output": [ "finding" ] }, { "id": "task1163-bdb50f8859294f78ac0bce823e15bace", "input": "while viral mRNA levels in infected cells remained unaltered in both groups.", "output": [ "method" ] }, { "id": "task1163-77c60a63a3a64319801300a24986ed4c", "input": "We propose that TDP-43 and FUS serve as an interface between genetic susceptibility and environmental stress exposure in disease pathogenesis.", "output": [ "purpose" ] }, { "id": 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statistical model to quantify the country-level risk of experiencing an importation of MERS case.", "output": [ "purpose" ] }, { "id": "task1163-889cc776568c4920b76ee5d10a444fb3", "input": "contact tracing and isolation was only potentially feasible when less than 1 % of transmission occurred before symptom onset.", "output": [ "finding" ] }, { "id": "task1163-a0836bc54f80459983fd1d081258eb2d", "input": "we examined the role of this receptor variant in cytopathicity and host range.", "output": [ "purpose" ] }, { "id": "task1163-a23ea2a898f94a74a8b806de27a97a76", "input": "and ability to accurately reflect disease progression in humans.", "output": [ "background" ] }, { "id": "task1163-b23d96f0e97842639b815991a4b6da9d", "input": "but also to family members.", "output": [ "background" ] }, { "id": "task1163-c901f63c2d1042009794024a1c916049", "input": "shared homologies with two other anti-viral mAbs.", "output": [ "finding" ] }, { "id": "task1163-cafec3be957149c7a009e105238657e0", "input": "Among contacts , the use of FFP2/FFP3 face masks during aerosol exposure was more frequent after MERS-CoV infection was suspected than before.", "output": [ "finding" ] }, { "id": "task1163-6e0cdaa07bde4a0c9ac57fcb20aed275", "input": "The global spread of SARS-CoV-2 requires an urgent need to find effective therapeutics for the treatment of COVID-19.", "output": [ "purpose" ] }, { "id": "task1163-80fb9e946c9c4f94a259f3b86434d207", "input": "Responses obtained from the groups were documented and similar results were aggregated using tallies.", "output": [ "method" ] }, { "id": "task1163-850a44a955604e07a6e215aa6a19f27d", "input": "We document the development of Fangcang shelter hospitals during the COVID-19 outbreak in China and explain their three key characteristics ( rapid construction , massive scale , and low cost ) and five essential functions ( isolation , triage , basic medical care , frequent monitoring and rapid referral , and essential living and social engagement ).", "output": [ "method" ] }, { "id": "task1163-1716134e024a4afdad18439ff091d0d4", "input": "endogenous 46 retrovirus-3 ( ERV-3 ).", "output": [ "method" ] }, { "id": "task1163-a46434d5039c4aae85e8f4bfc1e34bbc", "input": "comparative perspective on the virulence of all currently known human RNA virus species.", "output": [ "finding" ] }, { "id": "task1163-1405ac02e95449df8eabac6a2c3d56fc", "input": "In this study , we developed an alignment-free algorithm for faster sequence analysis.", "output": [ "purpose" ] }, { "id": "task1163-fa3f508ba587460b92d57716580613f4", "input": "MyD88 is dispensable for antiviral immunity.", "output": [ "background" ] }, { "id": "task1163-90c86ab454e44e96a2500bc16e82e47f", "input": "Representativ e example s of solubl e defens e agent s ar e liste d i n Tabl e I.", "output": [ "finding" ] }, { "id": "task1163-54bed1eac9ed43e28c23324d137ccbf6", "input": "Pigs ( 6 weeks old ) were orally immunized with ITGEV plus CpG DNA.", "output": [ "method" ] }, { "id": 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"input": "numerous researchers around the world have been working relentlessly to understand the biology of this virus.", "output": [ "background" ] }, { "id": "task1163-605ffae7a6854a66a6df323a7e25f85a", "input": "Practice of meditation or exercise may enhance health to protect against acute infectious illness.", "output": [ "background" ] }, { "id": "task1163-e4fb9d78271a4713b6a24c10910cbdfb", "input": "including design considerations and areas for future development in the field.", "output": [ "purpose" ] }, { "id": "task1163-22352c9665544bcbab08f3a5ed05e88a", "input": "Herein , we describe a loopmediated isothermal amplification ( LAMP ) assay that was developed for the quantitative detection of EEDV in infected fish tissues.", "output": [ "background" ] }, { "id": "task1163-85e046bbaf9c4fb1b760109a361e59f2", "input": "Here we determined the extent and functional importance of macrophage infection by MAV-1.", "output": [ "purpose" ] }, { "id": "task1163-6e7c7e50f8d347f1a4282613d4db444c", "input": "All stages of the HSV replication cycle offer potential targets for direct-acting antiviral ( DAA ) therapy.", "output": [ "background" ] }, { "id": "task1163-ab12499140da41fdac0d7a4386702c95", "input": "population density , and national response plans it was hypothesized that adherence to recommendations will vary.", "output": [ "purpose" ] }, { "id": "task1163-f1ec966ec1fb44a896e6ca3b42a831ef", "input": "agriculture , and so on.", "output": [ "background" ] }, { "id": "task1163-8320775cad00485a89a63c59aba627b5", "input": "but had little effect on HIV-1 replication in these cells.", "output": [ "finding" ] }, { "id": "task1163-d8c1545b065844c3a46c088ec446d7d0", "input": "and lack the capability to uncover the novel viruses that cause emerging viral infections.", "output": [ "background" ] }, { "id": "task1163-4cb60621701746e393da9275a6106e17", "input": "This approach provides a useful means to measure potential modulatory effects by virus infections or other agents upon feline macrophage gene expression.", "output": [ "finding" ] }, { "id": "task1163-11c73c1459e44fe38e2793e3449ecf29", "input": "We examined whether emotional acceptance moderates the association between proinflammatory cytokines and self-reported sickness symptoms in women recently diagnosed with breast cancer.", "output": [ "purpose" ] }, { "id": "task1163-6ef218a585f44ac9b12b487c78b62981", "input": "suggesting alternative mechanisms for TRIM25 action.", "output": [ "background" ] }, { "id": "task1163-57766d2ef8964e7d83bebd47c9e0e21d", "input": "A screen for known respiratory pathogens was performed on biopsy tissue.", "output": [ "method" ] }, { "id": "task1163-da31012e491d4f5294bc42dff75de2f4", "input": "To identify inhibitor candidates , we have analyzed hit compounds that emerged from a large-scale high-throughput screen for their ability to block replication of members of both the orthomyxovirus and paramyxovirus families.", "output": [ "purpose" ] }, { "id": "task1163-168a6756c6e24fa992c565fbc536c44c", "input": "A necropsy was performed , and the findings revealed right lobar pneumonia with a necrotizing hemorrhage of the entire right lung and one-half of the left lung.", "output": [ "finding" ] }, { "id": "task1163-d25b0d3913da460393775d01294c04be", "input": "Here , we compared the amino acid sequences of several representative CoVs.", "output": [ "method" ] }, { "id": "task1163-5cecc6894f664bdfb7e1eb9c7df465e5", "input": "We selected observational and experimental studies examining the impact on mental health of epidemic outbreaks on HCWs.", "output": [ "method" ] }, { "id": "task1163-914659f856c24171a8ee77cf8cdd7fc8", "input": "This paper highlights the growing evidence that Th17 cells play the core role in the complex adaptive immunity of EAE/MS and discusses the roles of the associated immune cells and cytokines.", "output": [ "purpose" ] }, { "id": "task1163-603b28f115174c708c3f36c59a041a01", "input": "indicating a tropism for the respiratory tract.", "output": [ "finding" ] }, { "id": "task1163-15eb281a8a174a6aaf311746a533bd9e", "input": "Animals : Two hundred and eighty-six calves < 21 days.", "output": [ "method" ] }, { "id": "task1163-ce6506f84b9e41b4bbf0047d0148c011", "input": "we isolated active RTCs from infected cells and used them to develop the first robust assay for their in vitro activity.", "output": [ "method" ] }, { "id": "task1163-9f7c564805a241cb93a18cf7080ac595", "input": "NSG and humanized NSG mice were infected with 100 O. volvulus infective larvae ( L3 ) for 4 to 12 weeks.", "output": [ "method" ] }, { "id": "task1163-bc70bc86efc241cebdfaea73616b3ac3", "input": "Objective : To determine the viral etiology and epidemiology of ILI in households.", "output": [ "purpose" ] }, { "id": "task1163-695383f8f90f4d769099d03b72fdef0a", "input": "In this study we show that the detrimental effects of angiotensin II ( Ang II ) were exacerbated in the hearts of aged apelin-gene-deficient mice.", "output": [ "purpose" ] }, { "id": "task1163-1239cc60a508490897b86ccde65b0c3a", "input": "Young infants are likely to acquire RSV infection from older children in the same household.", "output": [ "finding" ] }, { "id": "task1163-30c829a82e33493fabbebd666fc4a8da", "input": "In this study , a reverse transcription loopmediated isothermal amplification ( RT-LAMP ) was developed for detection of porcine epidemic diarrhea virus ( PEDV ).", "output": [ "purpose" ] }, { "id": "task1163-1f36b530a0c6456a8e15b98293056241", "input": "Nine of these peptides and one unrelated peptide were manually synthesized and their T cell responses were tested in vitro.", "output": [ "method" ] }, { "id": "task1163-d50cd0ea06ac4a76aa08e4a518e2e6d0", "input": "Hereby , we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China.", "output": [ "purpose" ] }, { "id": "task1163-3bef75002d2343cc93f854def61b21dc", "input": "3D G64S , has a significant replication defect and that wild-type ( WT ) and 3D G64S populations have similar adaptability in 2 distinct cellular environments.", "output": [ "finding" ] }, { "id": "task1163-63797c7c23f24abfaeb467a558ba651e", "input": "Spectrophotometric assays determined G6PD levels.", "output": [ "method" ] }, { "id": "task1163-86cf7b819f1248879e1fa240bf144b05", "input": "viral persistence is associated with epithelial cells of the nasopharynx in the upper respiratory tract and decreased levels of mRNA for several immunoregulatory cytokines in the infected tissues.", "output": [ "finding" ] }, { "id": "task1163-c12ac8cad1774489b918c7b3635c8df6", "input": "Enhanced surveillance of norovirus outbreaks between November 2009 and November 2011.", "output": [ "purpose" ] }, { "id": "task1163-d36e2fdafdd24783b6174e952ce6aed6", "input": "We compared major gene deletions between African and Arabian strains of the virus.", "output": [ "method" ] }, { "id": "task1163-567c6f0d21824218966ec7de5a1c59a8", "input": "Strains were considered genetically distinguishable if their restriction patterns differed by у3 bands ( 3 ).", "output": [ "finding" ] }, { "id": "task1163-1a0c16d7b78a4283a2acbb02d4f7ff0b", "input": "Study objectives were to explore the vaccination status and determinants in T2DM patients in southwestern Saudi Arabia.", "output": [ "purpose" ] }, { "id": "task1163-c44c8978ce49437799ba1b6217ebff8a", "input": "including the presence of a putative transmembrane protein encoded by an overlapping reading frame in ORF2.", "output": [ "finding" ] }, { "id": "task1163-e14fe5a27c134d6692eb73ec88718c13", "input": "Feline coronavirus ( FCoV ) is common among cats living indoors in groups.", "output": [ "background" ] }, { "id": "task1163-3d5a252ca10b4db994d2cbf7c39f9200", "input": "and further help in prescribing their vaccines against them.", "output": [ "background" ] }, { "id": "task1163-8e6b3d88a5e74d19891ca4f5e260a439", "input": "such as attachment and penetration.", "output": [ "background" ] }, { "id": "task1163-94b2891b89b74f8cba08b6eb035b3c3b", "input": "A Time-LYM % model ( TLM ) was established according to the descriptive studies and was validated in 92 hospitalized cases.", "output": [ "method" ] }, { "id": "task1163-8dcb8462767143b0ae70f075e37a7c2c", "input": "E2 , and the E1E2 complex.", "output": [ "method" ] }, { "id": "task1163-b2ce9d11895a445bb76bbfdf0e397551", "input": "Design : A retrospective approach was adopted.", "output": [ "method" ] }, { "id": "task1163-aadb5a7d06af4cfaa46073cf7f06379a", "input": "Results : SARS-CoV N is released from cells through an association with E protein-containing vesicles.", "output": [ "finding" ] }, { "id": "task1163-d5fd60dadcfa4525bbca82c55b99067c", "input": "Objective : To optimize clinical laboratory diagnosis of COVID-19 from suspect cases by Likelihood Ratio of SARS-CoV-2 IgM and IgG antibody.", "output": [ "purpose" ] }, { "id": "task1163-e08fbd7499014d639754950a21052516", "input": "and critically appraises how this may be applied within Canada.", "output": [ "purpose" ] }, { "id": "task1163-5b623995d1244d53a817a46765996bb8", "input": "Recently , an increasing number of studies have highlighted the promising effects of NM in inhibiting cancer progression.", "output": [ "background" ] }, { "id": "task1163-2fa2bf8132f046dca408dcb85a79c756", "input": "He also reported dark urine and anorexia.", "output": [ "background" ] }, { "id": "task1163-3fc95f93effe4df1b06551567a911819", "input": "It has therefore become more useful to study the similarities between these proteins that goes beyond their sequence homology.", "output": [ "background" ] }, { "id": "task1163-aed1136766b34dfcade295a7e33b0819", "input": "G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures.", "output": [ "background" ] }, { "id": "task1163-bb01886dd1534274bc63fdbd1aaa0fd1", "input": "2020 , through the exponential growth.", "output": [ "method" ] }, { "id": "task1163-cb4bfe561ea64d11ba7dcd2dabdb5294", "input": "are potent inhibitors of translation initiation.", "output": [ "background" ] }, { "id": "task1163-a67a8e47c9b44c909b9c3dff7ec8e0cf", "input": "In particular , this study pays attention to formulating a mathematical model for MERS transmission dynamics and estimating transmission rates.", "output": [ "purpose" ] }, { "id": "task1163-881bca5b92aa490086ddb28e0aece65f", "input": "and components of the ubiquitin pathway.", "output": [ "method" ] }, { "id": "task1163-3f8827cb2e3b48ee85cc782cb92e987e", "input": "in vitro , the phenotype of LPCs to create an ideal niche-like microenvironment.", "output": [ "purpose" ] }, { "id": "task1163-46002490b1bc4f488d3cd3a21142c606", "input": "PBs and SGs with different compositions may coexist in a single cell.", "output": [ "background" ] }, { "id": "task1163-a140cd70905245338f7348df2454e59d", "input": "Objectives : This study sought to examine the operational and organizational management of a major outbreak of Middle East Respiratory Syndrome ( MERS ) caused by a novel coronavirus ( MERS-CoV ) in the Kingdom of Saudi Arabia ( KSA ).", "output": [ "purpose" ] }, { "id": "task1163-fbeca2e3ab1f46af96903645762a12ba", "input": "and analyzed its clinical characteristics statistically.", "output": [ "method" ] }, { "id": "task1163-17fb7411ca3c4ae5be9977da2eac100f", "input": "Healthcare databases and sources of grey literature were searched in July 2013.", "output": [ "method" ] }, { "id": "task1163-172b7d909b7c4a3eb6055f9053791320", "input": "and these were analyzed for BRSV and BCV antibodies.", "output": [ "method" ] }, { "id": "task1163-0cbcf81b31cf40ac9de627e9f7f5d83c", "input": "focusing on their clinical applications as anticancer vaccines.", "output": [ "purpose" ] }, { "id": "task1163-eef5b6dea7de462f921ebac37f7d6f7b", "input": "Acute respiratory distress syndrome ( ARDS ) can be associated with various disorders.", "output": [ "background" ] }, { "id": "task1163-87c0550e6d3c46108806d10c8b302dcc", "input": "Nevertheless , timely diagnosis and systematic management of CRV infections in intensively treated hematology patients has a demonstrated potential to significantly improve outcome.", "output": [ "background" ] }, { "id": "task1163-186d520d18d84691a48d63b372033df2", "input": "A prospective case control study was performed in primary healthcare in Kronoberg County , Sweden.", "output": [ "method" ] }, { "id": "task1163-1f8518c4f10f4f3cb42bb21380c32108", "input": "as well as known polyomaviruses.", "output": [ "finding" ] }, { "id": "task1163-41ba549db0ba42098e31e31cef9dee54", "input": "Finally , a few mechanisms by which infection may exacerbate symptoms of MS and other neurological diseases are discussed.", "output": [ "purpose" ] }, { "id": "task1163-430b7248917345e58e26291e476bd2b0", "input": "35 Further , we also provide basic characteristics of the system.", "output": [ "purpose" ] }, { "id": "task1163-74b0e19170c5445ba70a2ee3f26d4e7a", "input": "political , and economic policies as the foci of upstream drivers of the public 's health.", "output": [ "method" ] }, { "id": "task1163-ecb1cdc1ba9c40e2a85652f9300b2ee3", "input": "Ongoing and future work will contribute to a more complete understanding of the lifecycles of retroviruses and RNA viruses and potentially lead to novel antiviral strategies.", "output": [ "purpose" ] }, { "id": "task1163-c1e9481d4079495cbd92883433867b31", "input": "Sensitivity analysis using different values of the serial interval showed that there was evidence to reject the null hypothesis provided the assumed serial interval was less than 2.5 days.", "output": [ "finding" ] }, { "id": "task1163-4e3d57f98c0748719088c83a66324718", "input": "prognosis and treatment , and for other broad public health outcomes.", "output": [ "purpose" ] }, { "id": "task1163-7ac7e27394d0451587f21dcc793cb90a", "input": "gastrointestinal and possibly neurological disorders.", "output": [ "background" ] }, { "id": "task1163-459e2db2ddbc46498702ca643b8d1b5c", "input": "However , there are few direct comparisons of different PCR assays.", "output": [ "background" ] }, { "id": "task1163-8e71b91f1132488da1ec4fc15f672e1e", "input": "Patients with AECOPD requiring hospitalization were recruited.", "output": [ "method" ] }, { "id": "task1163-cbfc4bf1e89d430584acb5003c4d5e00", "input": "We demonstrated that this did not interfere with translocation and glycosylation and yields biologically active proteins.", "output": [ "finding" ] }, { "id": "task1163-f4fef2ba22f54a85afa498f01f0a1ecd", "input": "demonstrating the capacity of mNGS to identify both known and novel viruses.", "output": [ "finding" ] }, { "id": "task1163-5a68754fcac74af08860f348a6ab7cd7", "input": "a serial interval distribution , and the estimated R0 into a model based on the assumption that daily incidence obeys approximately Poisson distribution determined by daily infectiousness.", "output": [ "method" ] }, { "id": "task1163-d90ec57f77464e6aa7240d37d92ccd03", "input": "particularly focusing on how conclusions differ for ` moderate ' ( R 0 1/4 1.7 ) and ` high ' ( R 0 1/4 2.0 ) transmission scenarios.", "output": [ "method" ] }, { "id": "task1163-82073675cac14d578821b4fc2e8db92c", "input": "respectively , of cav-1 and cav-2 in airway epithelium.", "output": [ "method" ] }, { "id": "task1163-e3265358ab7f48288560673a9d271756", "input": "These findings suggest that the resultant infiltration of immune cells into the brain during HSV-1 infection may cause as much damage as the virus itself.", "output": [ "finding" ] }, { "id": "task1163-d04f4e3ab8ac4c0abf4564207a16a6bb", "input": "FHTVTVNTL , HTTWTLTGY , and IELAGTLTL were selected.", "output": [ "method" ] }, { "id": "task1163-bdbe9173dc0c44d78f94298e54cab5bb", "input": "Diseases 2016 , 4 , 26 2 of 28 but with a much higher mortality rate of about 35 % ( 17 ).", "output": [ "background" ] }, { "id": "task1163-1beeb995f75749e48bc76178b76bc7da", "input": "Analyses performed with geNorm revealed that hypoxanthine phosphoribosyltransferase 1 ( HPRT1 ) and hydroxymethylbilane synthase ( HMBS ) were the two most stable reference genes in response to post-oviposition time alone ( POT ) or with nicarbazin treatment ( POT+N ) of laying hens.", "output": [ "finding" ] }, { "id": "task1163-9e2054815c474300aeb0f7ee17229cb6", "input": "neutralization , and is involved in the induction of protective immunity.", "output": [ "background" ] }, { "id": "task1163-59d03fb37a3f41acbf8e9614bec30e8f", "input": "On viral infection , `` autophagy '' and `` programmed cell death '' are two dynamically synchronized cell survival programs ; `` immune response '' is a cell defense program typically suppressed by viruses ; `` cell cycle alteration '' and `` lipid metabolic reprogramming '' are two altered cell housekeeping programs tunable in both directions.", "output": [ "background" ] }, { "id": "task1163-78af082638a444858622eecda560ce6a", "input": "Infectious bronchitis virus ( IBV ) causes a costly respiratory viral disease of chickens.", "output": [ "background" ] }, { "id": "task1163-ca752244dfdc4387a586df8d35a5fa9e", "input": "The aim of this study was to investigate whether co-administration of CQ during sporozoite immunization improves cellular responses and protective efficacy in Plasmodium berghei models.", "output": [ "purpose" ] }, { "id": "task1163-4995d052507b42afae5829b9b93678d9", "input": "Ferret recombinant IL-2 stimulated the proliferation of ferret lymph node cells and induced the expression of mRNA for IFN-g and Granzyme .", "output": [ "finding" ] }, { "id": "task1163-da733ab83e8246619a91fb5f68db79e3", "input": "In this study , the potential utility of transmission electron microscopy ( TEM ) in detecting nonbacterial pathogens in patients with severe pneumonia was retrospectively evaluated.", "output": [ "purpose" ] }, { "id": "task1163-25fdd4b285314f65b04b2cefd4d1de76", "input": "Specific suggestions are made to enhance the infectious diseases physician 's profile with the intent of encouraging debate , discussion , and action.", "output": [ "purpose" ] }, { "id": "task1163-56cf5459e6bb426db31bf1dda89997b2", "input": "HCoV − OC43 infections have rarely been investigated as healthcareassociated infections in this population.", "output": [ "background" ] }, { "id": "task1163-3e3fe656fa424432a260362f64dd8429", "input": "We developed an online tool so that results can be updated as new information becomes available.", "output": [ "method" ] }, { "id": "task1163-0c9428c553604bc1bd59bb093dc06cf8", "input": "Study design : 152 HAdV positive samples were genotyped by Sanger sequencing of a fragment of the hexon gene using published primers along with a newly developed primer set for enhanced genotyping of HAdV D. Phylogenetic analysis was used for genotyping and genotypes were compared with epidemiological information.", "output": [ "method" ] }, { "id": "task1163-a608c2d0f20e45fdbd0a101240061f5c", "input": "Furthermore , the review outlines the aspects remain unclear that urgently need to be solved in future research.", "output": [ "purpose" ] }, { "id": "task1163-46c75fea22b6496d9412956e56b70c61", "input": "Sudan and it included 140 individuals.", "output": [ "method" ] }, { "id": "task1163-cde4cae0c99d4f0996db63f68273a963", "input": "displaying a more resistant phenotype during IAV infection.", "output": [ "finding" ] }, { "id": "task1163-ac2fd32416df456ebbf280e0ddb506c3", "input": "Here , we fill this knowledge gap by developing and validating an analytical framework that requires only basic analytics from stochastic processes.", "output": [ "purpose" ] }, { "id": "task1163-402e7772e9a2495db00a564a734c89f0", "input": "However , ITP in association with coronavirus infection has not previously been reported.", "output": [ "background" ] }, { "id": "task1163-cdf5f300ad6e4b78a2e36686baa1d826", "input": "This frans splicing model predicts that the downstream portion of medRNA will be part of a branched structure and then be released as a free product ( minRNA ).", "output": [ "purpose" ] }, { "id": "task1163-302f4f810ad146aa9c31bc2ded9d3dbc", "input": "and Huangshan city in Anhui province.", "output": [ "purpose" ] }, { "id": "task1163-e9f0b915bee44f3c9dfffee3515879cb", "input": "and their membrane association and lipase cleavage were determined in cells.", "output": [ "method" ] }, { "id": "task1163-6c415f585313433abdff6c18cb37c2bd", "input": "In this study , we exposed tracheal organ cultures from rats to 95 % oxygen and 1 ppm ozone.", "output": [ "method" ] }, { "id": "task1163-53c6afe3978d4bf181cf80291e675f3a", "input": "We also identified 38 novel potential protein coding open reading frames that were absent in the current genome annotation.", "output": [ "finding" ] }, { "id": "task1163-293ea265793e4a8fbe511ce270bb2435", "input": "The cases were found to be older than the other travellers and both had co-morbidities.", "output": [ "finding" ] }, { "id": "task1163-d05bf95d9334441bbdb10ddde39bfea4", "input": "as well as ways that have been proposed by the National Institutes of Health to improve the state of this field.", "output": [ "purpose" ] }, { "id": "task1163-83316da648174afaaa101e89ad7d1354", "input": "bacterial expressed proteins in the serodiagnosis of coronavirus infections.", "output": [ "purpose" ] }, { "id": "task1163-add519817e64449490953bd36ae1a170", "input": "the One-Health framework can be used to investigate the critical pathways through which viruses are transported and transmitted.", "output": [ "background" ] }, { "id": "task1163-59efdc00139c459698e399198ef61d56", "input": "Parallel ribosome profiling and RNA sequencing of infected-cell time points was performed during the course of MHV replication in mouse tissue culture cells and used to determine virus gene expression kinetics and the relative translational efficiencies of virus and host mRNAs.", "output": [ "method" ] }, { "id": "task1163-61cedacc49da491f821bd0f997133f26", "input": "healthy adults , and patients with other respiratory virus infections.", "output": [ "method" ] }, { "id": "task1163-f1adf9d3988f4983b26d162d59bd7c3b", "input": "Metagenomic studies can provide this background but only when combined with essential metadata and following the `` FAIR '' ( Findable , Accessible , Interoperable , and Reusable ) data principles.", "output": [ "finding" ] }, { "id": "task1163-67797cd5d90f4780afbd721f79ebd693", "input": "potential protease inhibitors , were obtained under parallel solution-phase conditions.", "output": [ "method" ] }, { "id": "task1163-957c5985ddf04e139064176fc8ec1f75", "input": "along with a discounting factor to project the growth of outbreaks using only basic epidemiological information ( e.g. , daily incidence counts ).", "output": [ "method" ] }, { "id": "task1163-efa8f8ffcb8b450aa020ea68bd4e0014", "input": "After LPS administration , pigs were intensively monitored for clinical signs.", "output": [ "method" ] }, { "id": "task1163-0d3241ded2954848b8668a77ba643eee", "input": "We studied the changes in AGP glycosylation in the course of FIP.", "output": [ "purpose" ] }, { "id": "task1163-27bbd60438ea48f5896616df323da371", "input": "we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4.", "output": [ "method" ] }, { "id": "task1163-af1666f017444c189b94adcc44a8ab2c", "input": "The present study reports on the emergence and spread of recombinant clusters detected in Italy and Spain between 2012 and 2014.", "output": [ "purpose" ] }, { "id": "task1163-9b6a1a87852842569aa40ff3e1fc5be3", "input": "emergence and eventual evolution of a plethora of infectious pathogens.", "output": [ "background" ] }, { "id": "task1163-9c41caa655c84a1fa0d177dbe4f99157", "input": "treatment and outcome of children diagnosed with community-acquired MP pneumonia ( CAMP ) in a tertiary hospital in Valencia , Spain.", "output": [ "purpose" ] }, { "id": "task1163-12f19ee32f2c4d76ad4f6854e8801285", "input": "Methodology : To characterize the increased susceptibility to infections in LBW newborns we used microarray technology to identify differences in gene expression in LBW newborns ( n = 8 ) compared to NBW newborns ( n = 4 ) using cord blood.", "output": [ "method" ] }, { "id": "task1163-0c96343232ce4cfdba85a50f5be5cefb", "input": "The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season.", "output": [ "purpose" ] }, { "id": "task1163-246edfc0ec1e4b74892385fc8020df78", "input": "which facilitates BVDV replication in MDBK cells and impairs the innate immune response.", "output": [ "finding" ] }, { "id": "task1163-3f9cf6acceb04f5090ea9e0f5441a861", "input": "and attitude ( anxiety and perception of open communication with authorities ) were associated with practicing preventive measures.", "output": [ "finding" ] }, { "id": "task1163-5915771baedf494bbbffce83ef203be8", "input": "Such an understanding has practical impact in providing a rational basis for the design and development of antiviral strategies.", "output": [ "background" ] }, { "id": "task1163-ea6ee684ab4c44afbbaa0c29b1348677", "input": "We conducted a trial assessing the feasibility of using PCT algorithms with viral testing to guide antibiotic use in a US hospital.", "output": [ "purpose" ] }, { "id": "task1163-16cdc4e74d084427b99506dd674045d7", "input": "A solid phase colloidal gold immunoelectron microscopy ( IGEM ) technique for detecting bovine coronavirus ( BCV ) was developed and shown to be specific.", "output": [ "purpose" ] }, { "id": "task1163-55fb609ea6a74e1891673e302c7c92fd", "input": "In contrast , the epidemiology of ECoV and its relationship to diarrhea in foals are poorly understood in Japan.", "output": [ "background" ] }, { "id": "task1163-077a8305db4944a885c59ab919f13fdf", "input": "several prevention and treatment methods are applied at the different stages of SAON.", "output": [ "method" ] }, { "id": "task1163-5e2a9bf703eb405e9de86860ab348ae0", "input": "failure of these medications because of the drug resistance of microorganisms accompanied by a lack of alertness about the etiology of diseases often leads to fatal results.", "output": [ "background" ] }, { "id": "task1163-8683e3e4f58c45808be43ac92b17e8de", "input": "Demyelination occurs in infected white matter areas in the absence of inflammation.", "output": [ "background" ] }, { "id": "task1163-eaa5a429b2314938a1d099d4d5deb3f3", "input": "Compared with central Kentucky , ECoV is not prevalent among thoroughbred foals in the Hidaka district of Hokkaido.", "output": [ "finding" ] }, { "id": "task1163-b69cdd00b3c44de09524b3b29362e3ff", "input": "the nsp3 mutant , produced more viral RNA than wild-type virus.", "output": [ "finding" ] }, { "id": "task1163-088e7d6844f24ae0af25495c1720ecff", "input": "TRIM25 inhibits viral RNA synthesis through a direct mechanism that is independent of its ubiquitin ligase activity and the interferon pathway.", "output": [ "finding" ] }, { "id": "task1163-0e33234ec1c246af8ab6acc64b69a95b", "input": "alone as an effective method for the routine prevention of disease transmission.", "output": [ "method" ] }, { "id": "task1163-b4cb3b5dbbc745969cf882e8d9d144d3", "input": "Today , promoter methylation has been recognized as an important factor in long-term genome silencing.", "output": [ "background" ] }, { "id": "task1163-b57082cb2f154fb88b9b4aa43c34968c", "input": "without fragmentation and ligation of nucleic acids.", "output": [ "method" ] }, { "id": "task1163-760251d9d8494054861044c142c79917", "input": "The results show the difference of similarity between different stock markets in different time periods and the similarity of the two stock markets become larger after these two crises.", "output": [ "finding" ] }, { "id": "task1163-9120cd57d6a740f085bff7fed6894a4f", "input": "( iiii ) Epidemiological characteristics of a cluster of cases that occurred in July 2009 in a summer camp were analyzed.", "output": [ "method" ] }, { "id": "task1163-a9d67c08b56e4e5a88d2debf72249dab", "input": "In the present study , we compared different types of IFN-β-inducing and - non-inducing viruses in the context of Sendai virus infection.", "output": [ "purpose" ] }, { "id": "task1163-67bc2b9a4fce454e92fda2e2ecd5ac73", "input": "The induction of IFN-β was closely associated with the production of these unusual RNAs as well as the formation of the cytoplasmic structures.", "output": [ "finding" ] }, { "id": "task1163-6c8fff8005384150a38ba950f1f2bc19", "input": "and also that there is a comprehensive approach to mental health care for nurses during the chronic phase of a disaster.", "output": [ "finding" ] }, { "id": "task1163-f1387d3fcd454b3da54452b83731dd60", "input": "notably those with high antigenic diversity or those that do not elicit a bNAb response in the course of natural infection.", "output": [ "background" ] }, { "id": "task1163-2808858fe06c4e9681048422b25a0cf5", "input": "These results suggest that sIFITM3 is a promising antiviral agent and that can safeguard the host from infection with FMDV.", "output": [ "finding" ] }, { "id": "task1163-427c5f8ffc9648fb9bbeb4654441cc31", "input": "are making coordinated efforts to cope with many of the mentioned obstacles.", "output": [ "finding" ] }, { "id": "task1163-d5dbe758463f4422af531bfaf207d563", "input": "In this review , we cover the recent state of the art of human and animal studies and we discuss future potential challenges in the field of P. aeruginosa respiratory infections.", "output": [ "purpose" ] }, { "id": "task1163-2242cf3aaf2940679e9dcc218ca10b4a", "input": "To this aim , a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an α1 ,2 fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface.", "output": [ "method" ] }, { "id": "task1163-234a3767d0094b0da87735e317e721bf", "input": "which are essential for antiviral activity.", "output": [ "background" ] }, { "id": "task1163-ca74a441322f4cbdb8fe9d17017b79e5", "input": "Here we describe the generation of immortalized marmoset hepatic progenitor cells ( MHPCs ) by lentivirus-mediated transfer of the simian virus 40 large T antigen gene in fetal liver polygonal cells.", "output": [ "purpose" ] }, { "id": "task1163-ebb9c57b45044421a9650a16ef92810b", "input": "This study focuses on the visualization of smoke plume discharge and an uncertainty analysis is not applicable.", "output": [ "purpose" ] }, { "id": "task1163-6bff012152674f96a4ade8b86fd08b0c", "input": "even at 72 h after treatment ( P < 0.05 ).", "output": [ "finding" ] }, { "id": "task1163-8f38cf6326cd4ca1bfb3b158a2a08274", "input": "Matched controls were obtained from patients who died of other causes over the same interval.", "output": [ "method" ] }, { "id": "task1163-b7bdccbf08a34f9983c6756c24da32bf", "input": "refine , and replace animal use.", "output": [ "background" ] }, { "id": "task1163-d566fd03cb514a8e9059334f3c10f03e", "input": "formononetin , calycosin , 4 0 - O-b-glucopyranosyl-5-O-methylvisamminol ( GMV ) and cimifugin in rat plasma after oral administration of Yu Ping Feng San decoction.", "output": [ "purpose" ] }, { "id": "task1163-a7ffb611e4a54e4dad4f65aa2388fa8d", "input": "We parameterize an individual-based simulation model of pandemic influenza transmission 6 for Great Britain and the United States using high-resolution population density data 8 and data on travel patterns ( see Supplementary Information ).", "output": [ "method" ] }, { "id": "task1163-3d7c85c2eff54726817d4e2a65033d29", "input": "Enterovirus D68 ( EV-D68 ) is an emerging pathogen that recently caused a large outbreak of severe respiratory disease in the United States and other countries.", "output": [ "background" ] }, { "id": "task1163-fda0f118f2f64bb189ee0af21714c94f", "input": "IHA and ELISA titres were affected by different preparations of the crithidial antigen extracts.", "output": [ "finding" ] }, { "id": "task1163-1f78a08b41eb43b585ead57f7146fa6c", "input": "Case report.", "output": [ "finding" ] }, { "id": "task1163-75ef3afcff30485ea764b1548071d985", "input": "iv ) the statistical significance of G-quadruplex formation.", "output": [ "finding" ] }, { "id": "task1163-9b930e57f69c4dfcb00dcd0ccd00e3b2", "input": "We developed an institutional algorithm to protect operating room team members during the COVID-19 pandemic and rationally conserve personal protective equipment ( PPE ).", "output": [ "purpose" ] }, { "id": "task1163-e51cea7567bc4b458b0c4fbec7d8c08e", "input": "Here we describe the development of adeno-associated virus ( AAV ) vaccines expressing the NiV G protein.", "output": [ "purpose" ] }, { "id": "task1163-2ef8cb66392b4fe49776304156384b79", "input": "we isolated antibodies from a phage-27 displayed antibody library that was constructed from a patient who recovered from SFTS 28 virus ( SFTSV ) infection.", "output": [ "method" ] }, { "id": "task1163-368c5d34e3ef4f079c0d0b1712bb0167", "input": "We believe that prior experience with common conditions and the frequency of these conditions in the population may have intensified the ability to remember the plant-disease pairs associated with this group of diseases.", "output": [ "finding" ] }, { "id": "task1163-671fe85cd676408fb65a6530f96e1064", "input": "Japanese encephalitis virus and West Nile virus.", "output": [ "background" ] }, { "id": "task1163-d30cbc9f55ee4a1a99c531ccf9522b0f", "input": "Here , we compare three modes of epidemiological decisionmaking in the midst of a growing outbreak using network-based mathematical models that capture plausible heterogeneity in human contact patterns.", "output": [ "purpose" ] }, { "id": "task1163-939bab784e8d47b2b75b2954049b38b2", "input": "Forty cytokines were assayed in serum using the Quantibody Human Inflammation Array 3 ( Ray Biotech , Inc. ).", "output": [ "method" ] }, { "id": "task1163-602c816cde334ab2a8e06089794fb6fe", "input": "We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar.", "output": [ "purpose" ] }, { "id": "task1163-551c60b3a9604fb0b5db63a5fe1af116", "input": "The trial showed significantly reduced calf mortality in diarrheic calves that were administered lactoferrin.", "output": [ "background" ] }, { "id": "task1163-5893447df2164881b28a842894c9301b", "input": "and were immortalized with Epstein-Barr virus ( EBV ) and CpG in multiple wells.", "output": [ "method" ] }, { "id": "task1163-df58a116c5c141ff9ca94b671dd4e84a", "input": "so there is a still a gap in treatment for lesions in other areas of the body.", "output": [ "background" ] }, { "id": "task1163-030dffdb70a747a8bc648f831aa0e210", "input": "which has a long history of being a staple in the local human diet in Africa.", "output": [ "background" ] }, { "id": "task1163-23f3de06e2c44ca99ed6d01bca911bc0", "input": "Here , we found that GW3965 inhibited NDV infection in DF-1 cells.", "output": [ "finding" ] }, { "id": "task1163-48b3d23f1d42490781612678742fa343", "input": "their antimicrobial actions , and their delivery strategies.", "output": [ "purpose" ] }, { "id": "task1163-bd434043d07d4c85b16729a0831dcee4", "input": "A single swab was used to sample both nostrils.", "output": [ "method" ] }, { "id": "task1163-f7bd8bb7b35f46d999147deb5cd75a2d", "input": "We mapped the SARS morbidity data with the spatial data resolution at the level of street and township.", "output": [ "method" ] }, { "id": "task1163-2ca0ab49065c4bf68ac3b2aad2635fa4", "input": "it predominantly formed speckles in the cytoplasm.", "output": [ "finding" ] }, { "id": "task1163-e4f9b8ab1d44430c9028bc8bdc241534", "input": "Immunoreactivities for cav-1 and for cav-2 were co-localized in the cell membrane of the basal cells and basolaterally in the ciliated epithelial cells of large airways of rat and human.", "output": [ "method" ] }, { "id": "task1163-53e196f8b12a44498177c88821d3c519", "input": "who may be exposed to undiagnosed , yet infected patients.", "output": [ "purpose" ] }, { "id": "task1163-1923736a1b9f4485bd76ef4fe76bf70f", "input": "This study attempted to examine which viral protein might be involved in inducing UPR and whether this cellular event would lead to apoptosis of the cells expressing the viral protein.", "output": [ "purpose" ] }, { "id": "task1163-72e311404d294a68a336c1a4141cde2e", "input": "Lactobacilli and lactoferrin are largely under the influence of female hormones and of paracrine production of various cytokines.", "output": [ "background" ] }, { "id": "task1163-7024d4f2eaef4295ab4d79fbc43dc66b", "input": "Our early and recent studies on ARDS and PE may provide information for clinical practice and the understanding of the pathogenesis of SARS.", "output": [ "finding" ] }, { "id": "task1163-2e02518f90fa41c4873721a7aeff7777", "input": "We reviewed the results from several studies investigating cardiac miRNAs expression in rodent models of DOX-treatment.", "output": [ "purpose" ] }, { "id": "task1163-6d49d133c18d4f04a1b5a5243239d27b", "input": "Iterative HFold , for pseudoknotted RNA secondary structure prediction.", "output": [ "method" ] }, { "id": "task1163-ad233208e2d6409384e0b5ca9f472b2b", "input": "Objectives.", "output": [ "purpose" ] }, { "id": "task1163-c138e56eb05443f49564333ab934bd59", "input": "species , or environmental patches to overall transmission can aid management strategies.", "output": [ "finding" ] }, { "id": "task1163-f200dec1cd39496887b7a77f40ded59f", "input": "2020 , 355 cases have been confirmed as having COVID-19 infection on the Diamond Princess cruise ship.", "output": [ "background" ] }, { "id": "task1163-da96ec872b17459a8fc55798749f8171", "input": "effective , and readily available antiviral agents for treatment and prevention of acute Ebola virus ( EBOV ) disease ( EVD ) or sequelae 1.", "output": [ "background" ] }, { "id": "task1163-689c88d96e9d4f0387adc4ebd867a113", "input": "to characterize flavivirus evolutionary and biogeographic history in unprecedented detail and breadth.", "output": [ "method" ] }, { "id": "task1163-d4fc9fb64a9643b89a49ea1381f34e16", "input": "There are two biotypes of BVDV : non-cytopathic ( NCP ) and cytopathic ( CP ).", "output": [ "background" ] }, { "id": "task1163-1fcbe333ce664010b668dd3e8864d940", "input": "where highly divergent HIV-1 strains are prevalent.", "output": [ "method" ] }, { "id": "task1163-1001348947da4fe2b68deda2d954f203", "input": "however , was accurate or effective.", "output": [ "background" ] }, { "id": "task1163-3e2db53fbea24c669f8e2a2c8b646460", "input": "promoting infection of eukaryotic cells , and increasing coinfection rates.", "output": [ "background" ] }, { "id": "task1163-5d1f8e661d044916ab5e8f0b3d8beac0", "input": "indicates the need to develop novel vaccines that should be tested in improved animal model systems.", "output": [ "background" ] }, { "id": "task1163-b70362b94485402ba9c2b33f85bbfaf3", "input": "Cryptosporidium parvum , rotavirus , and coronavirus.", "output": [ "method" ] }, { "id": "task1163-703601cd7fd24e14ba5aea1952bbf19f", "input": "but lower than that of other reverse transcribing organisms.", "output": [ "background" ] }, { "id": "task1163-b723119e78ac4ec99fef99eacaef0a8d", "input": "We used the time between the first two cases of each outbreak to estimate the serial interval for norovirus in this setting.", "output": [ "method" ] }, { "id": "task1163-0d0f3527e2324f90afe1dfae912c56c8", "input": "Odisha was conducted between December 2012 to March 2013 and prevalence rate was studied on the basis of age , breed , and sex.", "output": [ "purpose" ] }, { "id": "task1163-07d0da92e77f44778be3e1c7e28867eb", "input": "Finally , applications for the future are discussed.", "output": [ "purpose" ] }, { "id": "task1163-64cd062c54a9432498d19e07d56ca36d", "input": "which was fundamentally different from the classically sheddase-induced proteolytic cleavage of ACE2.", "output": [ "finding" ] }, { "id": "task1163-14a20bc914e845c480d89a529a5cab26", "input": "in order to characterize the glomerulopathy prevalent in this species.", "output": [ "method" ] }, { "id": "task1163-6c4787869c9b43dfb95af5baee939a02", "input": "Codon composition analysis revealed these four species preferred to use pyrimidinerich codons more frequently than purine-rich codons.", "output": [ "finding" ] }, { "id": "task1163-a667530e11b94a43a9b5eafec732dc44", "input": "and decreased from 75.8 % to 54.7 % during the study period.", "output": [ "finding" ] }, { "id": "task1163-6c6ba7b456564809b6a796130ebc0fc6", "input": "we have used castanospermine to inhibit maturation of N-linked sugars in cell cultures of neurons or neurons plus Schwann cells.", "output": [ "method" ] }, { "id": "task1163-145de547952143af99cfb8496606f063", "input": "microarray and high throughput quantitative PCR have allowed researchers to study gene expression changes on a much broader scale.", "output": [ "background" ] }, { "id": "task1163-3da8730868404381b8130f79e25e6a5e", "input": "NQ 4 showed a fair antiviral activity against Herpesviruses ( EC 50 : < 0.4 µg/mL , < 1.28 µM ) and DENV-2 ( 1.6 µg/mL , 5.1 µM ) on pre-infective stages.", "output": [ "finding" ] }, { "id": "task1163-5061f40c2a3b43e9994af6ad13b25e0a", "input": "Let at time t , N h ( t ) represents total 59 host population and N v ( t ) represents total vector population.", "output": [ "method" ] }, { "id": "task1163-bdfc617741c5474fb3b1f97284d60206", "input": "the approach of cellular automata image is introduced to cope with this problem.", "output": [ "purpose" ] }, { "id": "task1163-3ff6768402ae478699e1b3d62e4855dd", "input": "Understanding mechanisms of reovirus bloodborne spread may shed light on how microbial pathogens invade the bloodstream to disseminate and cause disease in infected hosts.", "output": [ "finding" ] }, { "id": "task1163-ba636c25f1bb44b3b4eae865f8830d51", "input": "The current Ebola virus outbreak has highlighted the uncertainties surrounding many aspects of Ebola virus virology , including routes of transmission.", "output": [ "background" ] }, { "id": "task1163-dffd9cad23334f29a200af03c6c27cd6", "input": "Genetic studies too have linked various pathways in AD with those occurring on HSV1 infection.", "output": [ "finding" ] }, { "id": "task1163-a5294bcbdb3e4712afd44c941a53f5f8", "input": "2.78-9.68 ) and 2.57-fold ( 95 % CI , 1.35-4.88 ) increased risk of developing SARS respectively.", "output": [ "finding" ] }, { "id": "task1163-64d6ae3adbcf4e77887550dceb191559", "input": "In this review we focused on different ways viruses antagonize coding and noncoding RNAs in the host cell to its advantage.", "output": [ "purpose" ] }, { "id": "task1163-4eaa99ad827a4eba803d51097cbc9ffe", "input": "TGEV and SARS-CoV in host cells.", "output": [ "finding" ] }, { "id": "task1163-942d2463453a4f8082ffb889941cde36", "input": "At 4 °C , infectivity was barely reduced for up to 9 months.", "output": [ "finding" ] }, { "id": "task1163-25d0381824c44af99431c2a1cc8b62be", "input": "virtual drug screening and 61 high-throughput screening to repurpose existing drugs to target COVID-19 virus M pro.", "output": [ "method" ] }, { "id": "task1163-47fe3631f53548a4b62ce60a7ae8de77", "input": "while the existence of the Braess 's Paradox is insensitive to the network topologies.", "output": [ "finding" ] }, { "id": "task1163-3c43491e8d6943f2a2832cb012959375", "input": "Such outbreaks increase economic and infection control burdens.", "output": [ "background" ] }, { "id": "task1163-acb5939bacd0451fb55f0692a7e7a9d8", "input": "multiple potential infectors and censoring effects amplified by exponential growth.", "output": [ "purpose" ] }, { "id": "task1163-5e2f6b47c7fc483da6d26a65ca586f2f", "input": "called opacity-related ( Opa ) proteins.", "output": [ "background" ] }, { "id": "task1163-1c8b5b364ed841a192e0d1481c275480", "input": "A 1,7-bis ( alkylamino ) diazachrysene-based small molecule was previously identified as an inhibitor of the botulinum neurotoxin serotype A light chain metalloprotease.", "output": [ "background" ] }, { "id": "task1163-432b1f61670e4c5887d8696c847e9e0c", "input": "cDNA was synthesized by using SuperScript III First Strand Synthesis System for RT-PCR ( Invitrogen , USA ) with NR2 primer ( Table 1 ).", "output": [ "method" ] }, { "id": "task1163-cc02f396836f4e8cb329d71af0880d6e", "input": "Within the virion interior lies a helically symmetrical nucleocapsid that encloses a single-stranded and positive sense RNA viral genome of an extraordinarily large size of about 26 to 32 kilobases ( 20 ).", "output": [ "background" ] }, { "id": "task1163-3419c0b77b3d48a79a35c52e80653d2b", "input": "epidemiolopic studies of coronavirus infection in adults and children.", "output": [ "background" ] }, { "id": "task1163-a98bbdaa502c469d8eea5ebf9b1692f3", "input": "P2 and E2 for RVC structural genes 6 and 4 ( VP6 , and VP4 ) and non-structural gene 4 ( NSP4 ) , respectively.", "output": [ "finding" ] }, { "id": "task1163-a1d71e76017d4d9e84f22c36725a35ca", "input": "anxiety , and depression in 131 survivors of severe acute respiratory syndrome at 1 month and 3 months after discharge from the hospital.", "output": [ "method" ] }, { "id": "task1163-49d416d3bace495380170dbf41082481", "input": "Here , we study spatial organization of DNA synthesis during multiround transmission of herpes simplex virus ( HSV ) using pulse-labeling with ethynyl nucleotides and cycloaddition of azide fluorophores.", "output": [ "purpose" ] }, { "id": "task1163-f778d3f652df4c138838dc869fe93594", "input": "This work proposes a generalized type of lattice and illustrates how to use it in order to represent and compare biological data from different sources.", "output": [ "purpose" ] }, { "id": "task1163-e10b424b0cb24f299899d7d9d548aa78", "input": "Basal expression levels of IFNAR and Jak-STAT components are determinants of celltype-specifi c differences in cardiac antiviral responses.", "output": [ "finding" ] }, { "id": "task1163-75dcf576bd444b84bd7776cb5cb3a37b", "input": "Injection of chicken embryo with the GLTSCR2-specific shRNA-1370 simultaneously or 24 h prior to infection with Newcastle disease virus ( NDV ) substantially reduces viral replication in chicken embryo fibroblasts.", "output": [ "finding" ] }, { "id": "task1163-853d5563438c4ee9aaeb8860b18bfc37", "input": "The emergence of viral variants complicates disease control.", "output": [ "background" ] }, { "id": "task1163-6f40678b59324e93bfc349c1f37dfe84", "input": "All the test compounds barring 25 exhibited antifungal activity.", "output": [ "finding" ] }, { "id": "task1163-b887f029ade74f5b87d2b19be3eaa486", "input": "were collected and further screened for WU and KI using qPCR.", "output": [ "method" ] }, { "id": "task1163-4a2d61690be44b329d20be2a9233427b", "input": "which has been demonstrated to play a pivotal role in proteolytic processing of gene 1-encoded polyproteins.", "output": [ "background" ] }, { "id": "task1163-953685c40c894b39ad5636789d92d021", "input": "and assessed whether the persistent CNS infection can be modulated by manipulation of Tregs in the periphery.", "output": [ "purpose" ] }, { "id": "task1163-90424bd7a8f04069bcecd1ab1410c5d8", "input": "based on systematic literature reviews and expert consensus.", "output": [ "background" ] }, { "id": "task1163-3467387f52ad413caa41e0c576481529", "input": "its biology , immunology and epidemiology.", "output": [ "purpose" ] }, { "id": "task1163-5b634ace8401426395a5947d4b411ce8", "input": "Study design : We prospectively monitored the course of symptomatic respiratory virus infection in 18 SOT patients ( 14 lung , 3 liver , and 1 kidney ) using patient self-collected swabs.", "output": [ "method" ] }, { "id": "task1163-5f0bf5e06c834ebb914f27d717ccd487", "input": "and usability and cognitive task load ratings of the standard and redesigned gowns.", "output": [ "method" ] }, { "id": "task1163-0863bf5f640946b780e99e771de5a08e", "input": "We therefore used this approach to investigate the host response in dengue virusinfected cell lines and in patients developing dengue fever.", "output": [ "purpose" ] }, { "id": "task1163-eccd9a44e14340b0b6adce2527bab90f", "input": "the virological properties of African camel MERS-CoV were analyzed based on the spike ( S ) protein in Ethiopia.", "output": [ "purpose" ] }, { "id": "task1163-d1241385f39a41ad8c2e860843c9257b", "input": "The classification provides a new perspective on functional properties across a protein family and is able to highlight features important for potency and selectivity.", "output": [ "finding" ] }, { "id": "task1163-acd9ff57a1c84e82a8b6c980d28665c2", "input": "We identified factors associated with the Middle East Respiratory Syndrome-Coronavirus ( MERS-CoV ) infection among suspected cases presented with sign and symptoms of upper respiratory infection or exposure to the virus.", "output": [ "purpose" ] }, { "id": "task1163-70048ba97cff41d78055d9468dd485eb", "input": "y P < 0.05 vs. CII and vs. TI.", "output": [ "finding" ] }, { "id": "task1163-2bbcaa1127a74967bf658904cc793636", "input": "Conclusions : These results suggest that vitamin D 3 is a promising intervention for the prevention of URTI.", "output": [ "finding" ] }, { "id": "task1163-94ad99f92d7a40119e5469625ecc0767", "input": "Objective : To evaluate the scientific basis for the use of Kang 601 heji ( K-601 ) as an anti-inflammatory and antipyretic agent using appropriate animal models.", "output": [ "purpose" ] }, { "id": "task1163-ed7f0585c3734421b3b434daa3025882", "input": "M , in SSH cDNA library shows the long-term existence of SARS-CoV in vivo.", "output": [ "finding" ] }, { "id": "task1163-bbe5694794a8460b8f7b3edb84418476", "input": "Multiple sclerosis ( MS ) is a debilitating disease of the central nervous system ( CNS ) that has been extensively studied using the animal model experimental autoimmune encephalomyelitis ( EAE ).", "output": [ "background" ] }, { "id": "task1163-12a3286395bd46489136ddb5a8055ab1", "input": "In this article , some preliminary estimates will be presented.", "output": [ "purpose" ] }, { "id": "task1163-cafd01bde7fd49dfa67d270654ed2358", "input": "Background : Fit testing is used to determine whether a N95 mask will provide respiratory protection for the wearer by preventing inhalation of airborne transmitted microorganisms.", "output": [ "background" ] }, { "id": "task1163-c4d1a9396a614bf08bc44c7926093d48", "input": "indicating an increased probability of the highly ELISA reactive samples testing positive by the immunofluorescence assay.", "output": [ "finding" ] }, { "id": "task1163-de7bee7859ab4c1c9a07ac167097076d", "input": "suggesting that release of virus into the bloodstream from infected endothelial cells requires JAM-A.", "output": [ "finding" ] }, { "id": "task1163-c250f57a1d7f4ef5a7f3a3565161fa0a", "input": "other threshold quantities can be defined that are sometimes more useful and easily derived in terms of model parameters.", "output": [ "background" ] }, { "id": "task1163-d7a95822cfeb4690a9f99580ad4c3390", "input": "In virus-infected cells , MHV nsp15 distributed unevenly throughout the cytoplasm but predominantly in the perinuclear region.", "output": [ "finding" ] }, { "id": "task1163-74310dc709ce4755b0730e740ce5e58c", "input": "such as viral infection , has been implicated as one of the triggering events leading to neuroinflammation in multiple sclerosis.", "output": [ "background" ] }, { "id": "task1163-7b9529b5c20d461cabfbef5020e1df2e", "input": "Here , we reveal key features underlying the biochemical mechanism of target recognition and cleavage by the SOX endonuclease encoded by Kaposi 's sarcoma-associated herpesvirus ( KSHV ).", "output": [ "purpose" ] }, { "id": "task1163-0ce29c0f537743388c0a20734353e4ae", "input": "Bocaviruses were detected in three patients by RT-PCR.", "output": [ "finding" ] }, { "id": "task1163-69360943458a43708fd7b7c9cbaf6907", "input": "and hypoxic with an oxygen saturation of 93 % on 4 L per minute of oxygen supplementation.", "output": [ "background" ] }, { "id": "task1163-d12730e20b3e49c68ab0d35a36d40e43", "input": "but has only transient effects on physical and behavioural development of the pups.", "output": [ "method" ] }, { "id": "task1163-48042b8661b94e7cb4e4cbc46a46e970", "input": "LBW newborns are at greater risk to acquire recurrent bacterial and viral infections during their first few weeks of life possibly as an outcome of compromised innate immune functions.", "output": [ "background" ] }, { "id": "task1163-ad7c9039fb4147e3b03a680bab7e40e6", "input": "Immunotherapy with recombinant IFN-7 ameliorated disease as reflected by mortality rates and virus titers in target organs.", "output": [ "finding" ] }, { "id": "task1163-0188f48c01bd436f9ade62cdb76e2862", "input": "For some viruses the mechanism of membrane penetration is now known to be linked to a pH-mediated conformational change in external virion proteins.", "output": [ "background" ] }, { "id": "task1163-2bc290abb93548f5ac90cf6a3defe103", "input": "and logrank test was conducted for the association with clinical progression.", "output": [ "method" ] }, { "id": "task1163-38776b0527b7477a9ddf96f6e52523f1", "input": "The purpose of this study was to describe the clinical presentation of horses diagnosed with ECoV infection that were not associated with an outbreak.", "output": [ "purpose" ] }, { "id": "task1163-d9ef0d17a3194e648f6ec9bad4e5561a", "input": "and cytokines showed remarkable elevation.", "output": [ "finding" ] }, { "id": "task1163-44ccfb791e6743e0992e20b7e8689d55", "input": "and colonization to unprecedented levels.", "output": [ "background" ] }, { "id": "task1163-8f96130907554123bc3f504e6b4f6e64", "input": "We constructed two MVA-NiV-G vaccine candidates to express full-length NiV-G or the soluble form NiVsG.", "output": [ "method" ] }, { "id": "task1163-662f8d3938f24174bb9f1890449fe019", "input": "We conducted an epidemiological assessment of the travel group to identify likely source ( s ) of infection and presence of potential risk factors.", "output": [ "background" ] }, { "id": "task1163-725d974d8c264dbcbd49ad6d18664a1c", "input": "The production of DNA biochips is highlighted as are the operation and design of the experiments to reveal gene expression and SNP data.", "output": [ "purpose" ] }, { "id": "task1163-afda6baed5b8478eb701da17c20071cd", "input": "In the present study , we have tried to impose the vaccinomics approach for designing a common peptide vaccine candidate against the immunogenic SigA of Shigella spp..", "output": [ "purpose" ] }, { "id": "task1163-102ba9286f6745f9832d0af39a1ec254", "input": "to produce large amounts of heterologous viral glycoproteins in the allantoic cavity of embryonated eggs.", "output": [ "purpose" ] }, { "id": "task1163-759c7c1eb3504240a0d7657b860cf295", "input": "Keywords Epidemiology , human bocavirus , respiratory illness.", "output": [ "finding" ] }, { "id": "task1163-3645a4d807b441f88e60b9e589754191", "input": "The random forest approach predicted literature-assigned disease severity of test data with mean accuracy of 89.4 % compared to a null accuracy of 74.2 %.", "output": [ "finding" ] }, { "id": "task1163-329b9e2c1e66432dba268e85223ae17f", "input": "expressed in Escherichia coli , purified , and characterized.", "output": [ "method" ] }, { "id": "task1163-c8c8a67145ec4d83ba7dd61125f76a26", "input": "there has been a decade of studies that have clarified some aspects of its function but have also raised further questions.", "output": [ "background" ] }, { "id": "task1163-4921233a5db4417a8e875dd326d69a0f", "input": "with few exceptions ( e.g. , explicitly delayed self-repressors and simple models of specific organisms ' circadian clocks ).", "output": [ "background" ] }, { "id": "task1163-317f466ccc6149c2b7c1f3b86edec164", "input": "biochemical , and immunological assays in microbiology laboratories.", "output": [ "background" ] }, { "id": "task1163-d6d544d784d948ceabf0c15edd8e6f5c", "input": "NDV infection increased the mRNA levels of several lipogenic genes but decreased the ABCA1 mRNA level.", "output": [ "finding" ] }, { "id": "task1163-19097e6050df4ef18a18cd96c9e37624", "input": "and ( 4 ) stress-sensing proteins.", "output": [ "purpose" ] }, { "id": "task1163-0af00f66bf11495390a0f87dcd03c352", "input": "It is associated with significant mortality and morbidity.", "output": [ "background" ] }, { "id": "task1163-1394182526104165bdba19abcaada639", "input": "were collected and polycyclic aromatic hydrocarbons ( PAH ) properties in the ashes were investigated.", "output": [ "method" ] }, { "id": "task1163-af1d4c3ea2684955a959e9d59811317a", "input": "Fast simulation tools for the prediction of transient particle transport are critical in designing the air distribution indoors to reduce the exposure to indoor particles and associated health risks.", "output": [ "background" ] }, { "id": "task1163-6bfea350b8ed4b009037723f29a2a215", "input": "This review details the current options available for treating both influenza and noninfluenza related URIs in the professional voice user.", "output": [ "finding" ] }, { "id": "task1163-9d1cf26f931a469d8c0f9c43b906f437", "input": "In addition , an open-platform system is described that utilizes standardized reagents and methods and allows the user to develop in-house protocols.", "output": [ "purpose" ] }, { "id": "task1163-633a400533a4480983cfc0aa5efbfdb2", "input": "lymphangitis with breast cancer and fat embolism is caused by different mechanisms.", "output": [ "finding" ] }, { "id": "task1163-601f1091adc140f89065e71b226d7d07", "input": "The present study was conducted from May to June 2015 and included 70 dams with mink litters with and without PWD.", "output": [ "method" ] }, { "id": "task1163-efffb8b623cd4cd9b92149c273d208ff", "input": "Background A cluster of patients with coronavirus disease 2019 ( COVID-19 ) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) were successively reported in Wuhan , China.", "output": [ "background" ] }, { "id": "task1163-22495b65b9f14d1e8639256c149b32ed", "input": "By this mode the transmission of global and pandemic influenzas and infection between inland avian far from population and poultry or human living in cities along coast may be explained.", "output": [ "finding" ] }, { "id": "task1163-1cc1f0db72c741339af4aff9c887921a", "input": "The primary outcome measured was total antibiotic-days of therapy.", "output": [ "method" ] }, { "id": "task1163-d88c1edcc3134dd38a67d68dac8987fe", "input": "ER stress response , mitogen-activated protein kinase ( MAPK ) pathway and nuclear factor kappa B ( NF-κB ) pathway that may be modulated by HCoVs.", "output": [ "purpose" ] }, { "id": "task1163-af844a298c9f4540a0d86f65fe194185", "input": "Predictive risk maps of the transmission potential in different geographic areas of GB are presented for the fitted models.", "output": [ "finding" ] }, { "id": "task1163-13c0b9608f564250a70ebab2990e7c23", "input": "Translation efficiency in this expression system was enhanced significantly by employing the encephalomyocarditis virus ( EMCV ) 5 ' - untranslated region ( UTR ) which confers cap-independent translation by directing internal initiation of translation.", "output": [ "method" ] }, { "id": "task1163-d161e0adbcb84db287a110bd53ac9651", "input": "To assess the molecular mechanisms behind the induced apoptosis we studied the effects of hantavirus infection on cellular signaling pathways which promote cell survival.", "output": [ "purpose" ] }, { "id": "task1163-e8ea8a080cb8419896a20c4313589877", "input": "transition state ( bound with ADP-AlF 4 − ) and product state ( bound with ADP ).", "output": [ "method" ] }, { "id": "task1163-d582275c225b438283c92eed4c716cb0", "input": "In this study , we detect epidermal growth factor receptor ( EGFR ) autoantibodies using peptide array and screen the epitopes which are recognized by EGFR autoantibodies.", "output": [ "purpose" ] }, { "id": "task1163-57c08b67240240a1abc5426d950ed8b7", "input": "the building blocks should be of comparable reactivity and energy.", "output": [ "background" ] }, { "id": "task1163-8af46cc5a0474a038860c0a06d56ced4", "input": "we aimed to determine the minimum number of alert cases defining a cluster.", "output": [ "purpose" ] }, { "id": "task1163-ba0963a896884faf91d1380d99c74cf1", "input": "During two successive winters , faecal extracts from 110 children under 3 years of age were examined by electron microscopy with negative contrast.", "output": [ "method" ] }, { "id": "task1163-efd0657db3ec464bb72a2e49efb61f2c", "input": "and postweaning mortality did not differ between feeding treatments.", "output": [ "finding" ] }, { "id": "task1163-3c732b9f7bb349d391ca905147328c3a", "input": "Methods : Prospective cross-sectional observational study.", "output": [ "method" ] }, { "id": "task1163-85da54e778924057b857122ba69236ad", "input": "This article examines the evolution of the concept of global health and describes the driving forces that have accelerated interest in the field.", "output": [ "purpose" ] }, { "id": "task1163-a2a715e2827343e189cd00934c6fad1f", "input": "Design-Retrospective case series.", "output": [ "method" ] }, { "id": "task1163-d25478181e0c4fd08156264d34384032", "input": "with a particular emphasis on infectious diseases.", "output": [ "purpose" ] }, { "id": "task1163-9d97c521b2a140718510a9d22cff5acb", "input": "bacterial , fungal or parasitic infections.", "output": [ "purpose" ] }, { "id": "task1163-3f3a03ab7cf64c4d86f9f5d6305027ca", "input": "In this review , we summarize recent progress in TCHM-based antiviral research in China and other Asian countries.", "output": [ "purpose" ] }, { "id": "task1163-b5a84f13bebc42e79ce3b0400afa9142", "input": "The purpose of the present study was to identify potential biomarkers for SONFH.", "output": [ "purpose" ] }, { "id": "task1163-6cfefcb8e5ea4dc1b362cc3aa46307b1", "input": "By contrast , immunoblotting for HSV-1 antigens in purified virion preparations suggested that higher doses of Orthoquin had a physical impact on certain HSV-1 proteins that altered protein mobility or antigen detection.", "output": [ "finding" ] }, { "id": "task1163-24fcf5c944de4a68bd2799f75541aff7", "input": "and canine distemper virus for detailed description.", "output": [ "method" ] }, { "id": "task1163-47d25b4da92c4aaa84c5bbc9e99cbb47", "input": "However , the underlying mechanisms for Tat-mediated GFAP up-regulation are not understood.", "output": [ "background" ] }, { "id": "task1163-7d6f6661e5ac47fa88586aa1306987fd", "input": "Consistently , a fusion protein containing full-length Csl4 and NTD of DnaG led to enhanced degradation of A-rich RNA by the exosome.", "output": [ "finding" ] }, { "id": "task1163-6115e9c88e93466da94f97e88617f063", "input": "Escherichia coli , Clostridium perfringens and Eimeria spp..", "output": [ "method" ] }, { "id": "task1163-a83108277b0141d383a111c0fb555d00", "input": "Chemical shift perturbation mapping verifies that six of the eight compounds bind to cruzain at the active site.", "output": [ "finding" ] }, { "id": "task1163-58573b2865fe4ed88abce16b849d171f", "input": "sensitization status and clinical characteristics of patients having a respiratory infection caused by either different RV species or other respiratory viruses.", "output": [ "purpose" ] }, { "id": "task1163-237ff5ca19ce465289fc924c1e94492e", "input": "utilizing a simple water bath to maintain the reaction at 63 °C.", "output": [ "method" ] }, { "id": "task1163-68ae08f449494d8ab24ace57a8332553", "input": "and in most cases their efficacy is now being judged by their ability to reduce the frequency of acute exacerbations.", "output": [ "background" ] }, { "id": "task1163-6d97c4a5e3c742ffa42273f104296ed9", "input": "suggesting that NO is toxic to the lung in endotoxin shock.", "output": [ "finding" ] }, { "id": "task1163-e797f26a713e45218cde68fdbc88a371", "input": "ACE2 protein downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than ACE2 shedding.", "output": [ "finding" ] }, { "id": "task1163-29dac9b7f5234c78b3460bf4a1465bda", "input": "F protein refolding involves large conformational changes of the protein trimer.", "output": [ "background" ] }, { "id": "task1163-1f630d10e8634fc99be15d1a8be6c029", "input": "motion variance , and skin tone variance.", "output": [ "method" ] }, { "id": "task1163-c2a66191fcf144d9aff9a8afcfde981d", "input": "These levels of MVTT-S-induced Nab responses were substantially ( ,10-fold ) higher than that induced via the intramuscular route in the same experiments.", "output": [ "finding" ] }, { "id": "task1163-85c62bb7d68f41169795430d3896bb6d", "input": "probably by affecting cholesterol homeostasis.", "output": [ "finding" ] }, { "id": "task1163-d62e3dc361a84443bc5998ccae549bf1", "input": "We then inhibited SGLT1 expression by lentiviral interference and drug inhibition , respectively.", "output": [ "method" ] }, { "id": "task1163-73a611e1746642508e2ee5974aa88adb", "input": "Methods : On-site arrangements include mobile teams to 3 distant departments and same-service area vaccination for employees at 4 service areas.", "output": [ "method" ] }, { "id": "task1163-2dd5edc83c3f4fe0ad07608805ddc83f", "input": "are provided , and an emerging paradigm of lncRNAs in regulating innate immune responses is highlighted.", "output": [ "purpose" ] }, { "id": "task1163-15375340c76e48d69c053eff2d622680", "input": "Peripheral or central inflammation is characterized by an upregulation of cytokines and their receptors in the brain.", "output": [ "background" ] }, { "id": "task1163-fe26f3dbfa7e49839a06d9c8e59249da", "input": "We also discussed the data from two publications indicating the possible use of circulating miRNA as biomarkers of DOX-induced cardiotoxicity.", "output": [ "purpose" ] }, { "id": "task1163-a921a84631094932968c91ee0eb84ed1", "input": "lung consolidation , or average daily gain.", "output": [ "purpose" ] }, { "id": "task1163-d9f1ed7fe4e74c9b9caf16fae6fb55d2", "input": "This study analyzed the effects of different broiler production systems on health care costs in the Netherlands.", "output": [ "purpose" ] }, { "id": "task1163-ef377dce28c147569c2904a0ec011b6c", "input": "the decisions were made by consensus.", "output": [ "method" ] }, { "id": "task1163-d33622119c49488ab070d60772048f07", "input": "It is a major cause of morbidity and mortality in the newborn , particularly in premature infants.", "output": [ "background" ] }, { "id": "task1163-cf24a32fd614443d882458d4b4de415d", "input": "Gamma-and Deltacoronaviruses based on sequence comparisons of entire viral genomes ( 21 , 22 ).", "output": [ "background" ] }, { "id": "task1163-ae7ad09516784cb2930b1f1978f6a47b", "input": "Here we present a functional characterization of 2.5 Å and 3.25 Å X-ray crystal and small-angle X-ray scattering structures of RNase L bound to a natural 2-5A activator with and without ADP or the nonhydrolysable ATP mimetic AMP-PNP.", "output": [ "purpose" ] }, { "id": "task1163-0ca4942f656d4f80a6cd8796db453cf9", "input": "This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing , biotechnology and medicine.", "output": [ "purpose" ] }, { "id": "task1163-94b67dcf13214a919c2af1bbdee1365c", "input": "Objective : To describe aspects found on HRCT scans of the chest in patients infected with the influenza A ( H1N1 ) virus.", "output": [ "purpose" ] }, { "id": "task1163-3d2fbbb396bf4e2ba93497e3cfedf0e3", "input": "including edibility , fastgrowing , and a clonal proliferation.", "output": [ "background" ] }, { "id": "task1163-f648a372da2e4da08fcfb4efb2ebccb9", "input": "including particle modification , delivery and the factors associated with successful clinical deployment.", "output": [ "purpose" ] }, { "id": "task1163-1af1d346cd8e4a518a33d21a9807f821", "input": "Probability of introduction through animal purchase was calculated by using real animal movement data and herd prevalence in the region of the source herd.", "output": [ "method" ] }, { "id": "task1163-52cf1a9d495f4c948308d51e93a1cf98", "input": "risk of exposure and conservation of PPE.", "output": [ "method" ] }, { "id": "task1163-4857262e78b644af8b480b30f8a57bc5", "input": "reflecting the high sensitivity of the tests.", "output": [ "finding" ] }, { "id": "task1163-cd1457ad1f154c7ca5033ac9042d2e30", "input": "as well as wildlife ( 28,29 ) and farm animals ( 30 ).", "output": [ "background" ] }, { "id": "task1163-2563dc53f7874090a63a2cc25ac38727", "input": "We present an optimized probe design for copy number variation ( CNV ) and SNP genotyping in the Plasmodium falciparum genome.", "output": [ "purpose" ] }, { "id": "task1163-93cc842af1ab46d6affc41f491289e2b", "input": "More comprehensive research into sources of infection in the Arabian Peninsula is needed to strengthen and specify the prevention of MERS-CoV infections.", "output": [ "finding" ] }, { "id": "task1163-0fd5292300484c8ab575548c7dee3411", "input": "specificity and positive predictive value ( PPV ).", "output": [ "method" ] }, { "id": "task1163-53fb390fd7124c3dad800002bae05378", "input": "We found that the incubation period and lag between the onset of symptoms and diagnosis 50 of COVID-19 is longer than other respiratory viral infections including MERS and SARS ; 51.", "output": [ "finding" ] }, { "id": "task1163-d08d2bd624624167856a6d8e44df53a0", "input": "In PDT , photosensitizer compounds when exposed to visible light react with oxygen to generate reactive oxygen species ( ROS ) that include singlet oxygen ( 15 ).", "output": [ "finding" ] }, { "id": "task1163-e4b7990378b04d37aafd1b07c1740934", "input": "which has been linked to the likely effects of reactivation of the virus in brain.", "output": [ "finding" ] }, { "id": "task1163-5ccac42d15334b9b94262e2816e69081", "input": "and discuss the use of this information to assist in future disaster planning and crisis communications.", "output": [ "purpose" ] }, { "id": "task1163-5a149cc9af7f433fb2b3095928d2be20", "input": "emphasizing the recent developments along with some historical perspective.", "output": [ "purpose" ] }, { "id": "task1163-394f804bdb45461c8c50ee2d9c7bc66e", "input": "It was proven by Western blotting that the recombinant membrane protein had strong positive reactions with TGEV-specific antibody.", "output": [ "finding" ] }, { "id": "task1163-dd9b1cb9f8b94607bd7db95431a394c4", "input": "Here , we first present the structure of the full-length Nsp13 helicase of SARS-CoV ( SARS-Nsp13 ) and investigate the structural coordination of its five domains and how these contribute to its translocation and unwinding activity.", "output": [ "purpose" ] }, { "id": "task1163-cb0f963fc9554a29a3e090f9e3a82358", "input": "The spatio-temporal parameters of CM biogenesis and mitochondria elongation are linked to loss of activation of the fission factor Dynamin-Related Protein-1.", "output": [ "finding" ] }, { "id": "task1163-650dc9e306324a559f3b6b545c6f8195", "input": "Furthermore , there was a large difference in the proportion of test positive herds between the first and fourth quartile of PostPFree.", "output": [ "finding" ] }, { "id": "task1163-d1ae350d42244351b4016f5a2e41ad24", "input": "Implementation of the workshop recommendations is expected to advance alternative in vitro methods for veterinary vaccine potency testing that will benefit animal welfare and replace animal use while ensuring continued protection of human and animal health.", "output": [ "finding" ] }, { "id": "task1163-6cbf7da68c8d40baa5c12fc73ac3857b", "input": "as one of the epicenters of the disease in the first months of 2020.", "output": [ "purpose" ] }, { "id": "task1163-5f4ee7422d704045bd9ef234e39df3d9", "input": "and that deletion of the early growth response 1 ( Egr-1 ) cis-transacting element within the p300 promoter abolishes Tat-induced GFAP expression.", "output": [ "background" ] }, { "id": "task1163-9e9812f66f964813ac0bc030db695eea", "input": "and the usefulness of the most frequently applied animal models to study these conditions.", "output": [ "purpose" ] }, { "id": "task1163-7b2237ed4ead42dfac8ecf4ea5d48b6c", "input": "and typical bacteria ( 2.5 ng/mL ; IQR , 0.29-12.2 ng/mL ; P < .01 ).", "output": [ "finding" ] }, { "id": "task1163-4aa7f2fc7850408ab104ff90025a9ee5", "input": "was an unprecedented complex disaster that caused a nuclear accident at the Fukushima Daiichi Nuclear Power Plant ( NPP ).", "output": [ "background" ] }, { "id": "task1163-5cf2b30bd42f4eac82acb4168f9eafa9", "input": "on the activation of lipopolysaccharide ( LPS ) - stimulated murine bone marrow-derived DCs was examined.", "output": [ "purpose" ] }, { "id": "task1163-3f25ee4033c041fdb677e99120c0be4e", "input": "based on the scientific literature.", "output": [ "purpose" ] }, { "id": "task1163-d953d17b94694a18b96e262c4a954db1", "input": "( 2 ) a 130 kDa protein that was glycosylated and behaved as a disulfide-linked dimer of 65 kDa molecules.", "output": [ "finding" ] }, { "id": "task1163-660a9d2915e64051a389f2efe73abfbc", "input": "Four of them were considered as the most promising candidates for immunodiagnostics.", "output": [ "finding" ] }, { "id": "task1163-e0d40f49878a43338026f3d967cd2a24", "input": "Fisher 's exact test was used to compare CT findings depending on the shape of pulmonary lesions.", "output": [ "method" ] }, { "id": "task1163-4c0ab3146bd54ce3994ca2aa03bf4282", "input": "A single radial haemolysis ( SRH ) for reovirus antibody determination was developed and compared to standard haemagglutination-inhibition ( HI ) and complement fixation ( CF ) techniques.", "output": [ "method" ] }, { "id": "task1163-724faa61face427581cad34925fe2ebe", "input": "coronavirus , and other early diagnostic substances as confirmed by literature resources.", "output": [ "purpose" ] }, { "id": "task1163-543b9e5d5b1b475e8b2fe20099292dee", "input": "and has been promoted by projects like the global virome project ( 31 ).", "output": [ "background" ] }, { "id": "task1163-85cc7ec424f04c2ebdf9e0b96f23a5b5", "input": "Two patients were asymptomatic and negative for chest CT scan throughout the disease courses.", "output": [ "finding" ] }, { "id": "task1163-c07c89b40b7e4b869fb5c9387d5522f9", "input": "The present study investigates outcomes with respect to cardiopulmonary arrest rates in institutions with and without rapid response systems ( RRSs ) and the current level of cardiopulmonary arrest rate in tertiary hospitals.", "output": [ "purpose" ] }, { "id": "task1163-8bf59d978cb349d6889a4ec8261a16e8", "input": "is a prerequisite for systems level analysis.", "output": [ "background" ] }, { "id": "task1163-fe850fad524c47bfa190a19894669ebc", "input": "Recombination events were detected within alignments of the three complete CP and RdRp sequences of GaRV-MS1.", "output": [ "finding" ] }, { "id": "task1163-bde1dbd9197b493b89c3562b648857fd", "input": "The health monitoring scenario investigates the feasibility of health monitoring at public spaces ( i.e. airports , subways , malls ).", "output": [ "method" ] }, { "id": "task1163-2ca9f1309bf947cdb8b4c5a23313d819", "input": "52 class III genes , nineteen class I genes/gene fragments ( FLAI-A to FLAI-S ).", "output": [ "background" ] }, { "id": "task1163-9232292939614193a5228dac52f59caf", "input": "with few data on the virome of small ruminants and respiratory virome of studied livestock.", "output": [ "finding" ] }, { "id": "task1163-25c0408584934417995053df98db16ed", "input": "and compared the frequency of infections among subgroups.", "output": [ "method" ] }, { "id": "task1163-e16ab8cc3e784b66865604389f7d2b3d", "input": "organ weights , and histopathology were evaluated.", "output": [ "method" ] }, { "id": "task1163-bb8c5ec98c614c43a60f5159fab53546", "input": "influenza A/H3N2 ( A/H3 ) and other respiratory virus infections in hospitalised patients.", "output": [ "purpose" ] }, { "id": "task1163-6fd9ed51d6ca4f71a969bf00f1f441ed", "input": "With few exceptions , ؊ 1 PRF occurs on specific `` slippery '' heptanucleotide sequences and is stimulated by RNA structure beginning 5 to 9 nucleotides ( nt ) downstream of the slippery site.", "output": [ "background" ] }, { "id": "task1163-ee1fe2d6bd4444f89b458f255ab09252", "input": "the development of vaccines and antiviral agents for SARS-CoV is essential for improving control and treatment of future outbreaks.", "output": [ "background" ] }, { "id": "task1163-8c3e616c3eeb482f9ded0ebd048644e6", "input": "coiled-coil proteins and Rab guanosine triphosphatases.", "output": [ "background" ] }, { "id": "task1163-38e313ae39504a8487b9c5cdd84e2fc8", "input": "A procalcitonin threshold of 0.1 ng/mL resulted in 80.9 % ( 95 % CI , 75.3 % -85.7 % ) sensitivity and 51.6 % ( 95 % CI , 46.6 % -56.5 % ) specificity for identification of any bacterial pathogen.", "output": [ "finding" ] }, { "id": "task1163-6c6c8ed0e62f453f8ad8b42f644c7045", "input": "along with related significant advances since 2011.", "output": [ "purpose" ] }, { "id": "task1163-e56480dc4af240f4a21add823d818715", "input": "suggesting that the extreme C-terminal region may be dispensable for the proteolytic activity of the proteinase.", "output": [ "finding" ] }, { "id": "task1163-3bc0cabc4b864fd088a4a0a3e208909b", "input": "We report the backbone amide and side chain carbon chemical shift assignments of cruzain in complex with K777.", "output": [ "method" ] }, { "id": "task1163-b32229ba851042159cd3e608cd3c823d", "input": "Developing a deeper understanding of livestock virome is crucial for detection of potential zoonotic and animal pathogens and One Health preparedness.", "output": [ "finding" ] }, { "id": "task1163-bfbb674d07bb430489913683b3d990f0", "input": "and the cognate molecular motors myosin , dynein , and kinesin.", "output": [ "background" ] }, { "id": "task1163-fc91996b1b914c78a606a216386aa0a6", "input": "we also attempt to demonstrate some of the limitations encountered in developing control strategies to reduce the impact of future emerging arbovirus diseases.", "output": [ "purpose" ] }, { "id": "task1163-4b12d6c335114370a0dd08a4cd05e2d3", "input": "Understand the challenges that public health officials and emergency management practitioners might face when an intentional release of a Category C agent occurs in their community.", "output": [ "purpose" ] }, { "id": "task1163-99876f27e56d48aa821f5684655bc6fa", "input": "as well as the ability of EV-D68 to manipulate host cell cycle progression.", "output": [ "purpose" ] }, { "id": "task1163-961c67635a944b33a8370de88ad72960", "input": "and compared their immunogenicity and protection against SARS-CoV infection in an established mouse model.", "output": [ "purpose" ] }, { "id": "task1163-6fe2410f9e1347d187ca967ef1b984f9", "input": "are used to demonstrate the scope of our cluster approach.", "output": [ "method" ] }, { "id": "task1163-db1f8f6522974a3c9211918c1496614e", "input": "caprylic ( C8 ) , and capric acids ( C10 ) and applied with an aerosolizing nozzle ; 4 ) treatment 3 applied directly into the mixer without an aerosolizing nozzle ; 5 ) 0.66 % caproic acid ; 6 ) 0.66 % caprylic acid ; 7 ) 0.66 % capric acid ; 8 ) 0.66 % lauric acid ; 9 ) 1 % blend of 1:1 capric and lauric acids ; 10 ) 0.3 % commercially available dry C12 product ; 11 ) 1 % canola oil ; 12 ) 1 % choice white grease ; 13 ) 2 % coconut oil ; 14 ) 1 % coconut oil ; 15 ) 2 % palm kernel oil ; 16 ) 1 % palm kernel oil ; 17 ) 1 % soy oil and four analysis days ( 0 , 1 , 3 , and 7 post inoculation ) as well as 1 treatment of PEDVnegative feed without chemical treatment.", "output": [ "method" ] }, { "id": "task1163-d5c0f9ad92064002b567ea272883fc2b", "input": "we performed systematic mutation analyses to identify residues critical for 3CL pro dimerization and activity in this study.", "output": [ "background" ] }, { "id": "task1163-be040e40761846f8a38328267f6402ab", "input": "Clinical effectiveness of the antimicrobial agent used was evaluated on the basis of clinical outcome as well as micro-biological outcome of the trial.", "output": [ "method" ] }, { "id": "task1163-ce524be4af374b07835f076efd164ccc", "input": "This review presents a brief outline and novel developments of electrophoretic separation in microfluidic chips.", "output": [ "purpose" ] }, { "id": "task1163-bdd27d18ec4a414e99065f4a70befcbc", "input": "Similar identity matrix and determination of the most common ancestor were used to compare clusters of patient 's sequences.", "output": [ "method" ] }, { "id": "task1163-c05ab811d0d4407e81e88afd1143be54", "input": "in the spread of norovirus during outbreaks in hospitals.", "output": [ "purpose" ] }, { "id": "task1163-0823e1cc2f2f4f23b3949a6d5032d2cf", "input": "However , a decrease in shedding was seen for the more viscous gel group in the second cycle ( days 12 to 15 post-vaccination ).", "output": [ "finding" ] }, { "id": "task1163-ef41da59dbed43c384f40e75fd34641d", "input": "Recovered worms were identified as Pharyngostomum cordatum by morphological observation and genetic analysis.", "output": [ "finding" ] }, { "id": "task1163-834824a6eb0646dcb27abdd1509a3cc7", "input": "The examination included monitoring respiratory tract infection symptoms ( cough , expectoration or gasping ) and vital signs.", "output": [ "method" ] }, { "id": "task1163-756dba78824d4ccda67a36870a27a822", "input": "which showed petechial and ecchymotic hemorrhages , respectively.", "output": [ "finding" ] }, { "id": "task1163-e4aa5af5c02f4706bbdd1c497a60db21", "input": "This study compares 4 different multiplex PCR assays for the recovery of common respiratory viruses.", "output": [ "purpose" ] }, { "id": "task1163-c19db1dbfee341b2a0f96874c05f83b7", "input": "Conclusions : HCoV − OC43 may be implicated in healthcare-associated infections.", "output": [ "finding" ] }, { "id": "task1163-b308339893f4414a9c93339d04c0ebac", "input": "The ovine partetravirus is a novel partetravirus and phylogenetically most related to the bovine partetraviruses.", "output": [ "finding" ] }, { "id": "task1163-cf601d41980a4a289412e11374e9b1b3", "input": "Knowledge of clinical presentation and age-related variations among seasonal viruses may give a clue about severe course and prognosis.", "output": [ "finding" ] }, { "id": "task1163-a37866e1dfab49c6846c88517b31715e", "input": "Six of these inhibit M pro with 43 IC50 values ranging from 0.67 to 21.4 μM.", "output": [ "method" ] }, { "id": "task1163-2630807fec8542d997852c580c43a924", "input": "while cellsurface expression was reduced by less than 20 %.", "output": [ "finding" ] }, { "id": "task1163-07ef5bcbaf7d4c40bb95a5e75287745a", "input": "light , and oxygen to create a local burst of reactive oxygen species that inactivate microorganisms.", "output": [ "background" ] }, { "id": "task1163-7334f4e37f2047868a0820a2c47fc57f", "input": "Analytical expression representing the epidemic growth rate is obtained for the system.", "output": [ "method" ] }, { "id": "task1163-11761ac2a39b4f139317aba4336905a3", "input": "Meanwhile healthy volunteers of similar age that accepted routine check-ups and showed no clinical symptoms of inflammatory diseases were also recruited.", "output": [ "method" ] }, { "id": "task1163-df57db37619145f38f662d6ba9ce9794", "input": "course of the disease is associated with viral persistence in the nervous system.", "output": [ "finding" ] }, { "id": "task1163-802efb5a2b6d4345b0391aa4011d2fdc", "input": "The protocol can either be applied to screen complex host cDNA libraries or protein pairs arrayed for cross-testing.", "output": [ "method" ] }, { "id": "task1163-7203943abdf84a06a81b143b9948227e", "input": "illuminated by the application to sickle-cell anemia.", "output": [ "method" ] }, { "id": "task1163-61c01d4c16de4de9bdf385c0233b8ea3", "input": "In isolated perfused lung , exogenous and endogenous NO enhances lung injury following air embolism and ischemia/reperfusion.", "output": [ "finding" ] }, { "id": "task1163-ee2ca9735dad4e79aeaf0ab9f3c39eb9", "input": "angiotensin II type 1 receptor ; GBM , glomerular basement membrane.", "output": [ "background" ] }, { "id": "task1163-7c2120b880a1465ea343ad54cbbd7b6f", "input": "there are still some shortages.", "output": [ "background" ] }, { "id": "task1163-9ebaf8ed7d4a47cd8a05329d5e87c499", "input": "the advantages that are conferred to the virus and some of the major unknowns that provide motivation for further exploration.", "output": [ "purpose" ] }, { "id": "task1163-1f0ecd9d8cee4613afeb53c89e3e3729", "input": "Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.", "output": [ "purpose" ] }, { "id": "task1163-0c6333b14b174ab8bed00d8405e65e34", "input": "The phylogenetic profiling cluster of homolog proteins of one annotated 2019-nCoV protein against other genome sequences revealed two clades of ten 2019-nCoV proteins.", "output": [ "finding" ] }, { "id": "task1163-dae489f84c0943cebc28b84ea87902ef", "input": "this study took a pragmatic approach to exploring the interface between public health education and public health practice.", "output": [ "purpose" ] }, { "id": "task1163-74b12d7f44bd44c99d2c7f4a95e1b3c6", "input": "Infectious bronchitis virus ( IBV ) infections in poultry cause great economic losses to the poultry industry worldwide.", "output": [ "background" ] }, { "id": "task1163-c2bf53f598024d34af26f53168494e28", "input": "We used multiplex real-time PCR to detect 16 respiratory viruses and seven bacterial pathogens from nasopharyngeal swabs.", "output": [ "method" ] }, { "id": "task1163-56b742799e8d4025af98817ea7322861", "input": "Human immunodeficiency virus type 1 ( HIV-1 ) Tat plays an important role in HIV-associated neuropathogenesis ; the underlying mechanisms are still evolving.", "output": [ "background" ] }, { "id": "task1163-5b9dec645bfb4ad6aa2b0b7169736e80", "input": "Such an increase is a challenge and adds cost to the healthcare system.", "output": [ "finding" ] }, { "id": "task1163-c180f41dcaae4dc6a9f4e6d9c29914ac", "input": "but not by astrocytes , in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis.", "output": [ "method" ] }, { "id": "task1163-2840baef639142149d2f36f68e03b5af", "input": "Human coronaviruses ( HCoVs ) are known respiratory pathogens associated with a range of respiratory outcomes.", "output": [ "background" ] }, { "id": "task1163-73b9a0ec0b784be7ac5df426e9de8811", "input": "BrdU incubation time and antigen presenting cell type.", "output": [ "method" ] }, { "id": "task1163-8364aed9e1994b22817595d2a851acc5", "input": "rayon-budded swab in a transport tube with a foam 37 pad reservoir soaked with viral transport medium ( Virocult MW950 , Medical Wire & Equipment , 38 Wiltshire , England ).", "output": [ "method" ] }, { "id": "task1163-5e8641c775054cd4a0ff34b01d9e7c06", "input": "HCoV − OC43 isolates collected from HSCT patients were retrospectively characterized to identify potential clusters of infection that may stand for a hospital transmission.", "output": [ "purpose" ] }, { "id": "task1163-70de161c342244cea8b186fef2dfea1e", "input": "We report the clinical course of MERS-CoV infection in a pregnant woman who acquired the infection during the last trimester.", "output": [ "purpose" ] }, { "id": "task1163-d1ecdd36161743fea1a8be09547b66e4", "input": "and as global collaboration is sought in numerous quarters.", "output": [ "background" ] }, { "id": "task1163-4648e2eb43f04af4b5bced112ad2ee93", "input": "Additionally , AQ 11 can be considered of interest as a leader for the design of new anticancer agents.", "output": [ "finding" ] }, { "id": "task1163-3746ca5f5237468db430b4697b023bde", "input": "but was largely unaffected for cysteine cluster III and IV mutants.", "output": [ "finding" ] }, { "id": "task1163-df93e2c4861d418c8d26b62725df030d", "input": "and thus the alert system proposed is not likely to result in large numbers of false positive alerts.", "output": [ "finding" ] }, { "id": "task1163-bc384455455f4d779fdc0399d0287c8f", "input": "A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers.", "output": [ "method" ] }, { "id": "task1163-4af58508092e40578d38566f6bb7fcb9", "input": "This may relate to various disease processes such as inflammation or malignant transformation.", "output": [ "finding" ] } ], "Instance License": [ "Unknown" ] }